Claims
- 1. A process for the preparation of an aniline compound chlorinated on the ring, and having at least one carbon atom of sp3 hybridization, which is perhalogenated and carries a fluorine atom, said process comprising the step of chlorination of a precursor aniline compound, in a hydrofluoric acid medium capable of exchanging a chlorine atom and a fluorine atom in a benzyl position or on said carbon atom of sp3 hybridization carrying a chalcogen atom, said precursor aniline compound being of the formula: wherein:Z represents a single bond or the chalcogen atom; X1, X2, and X3 represent identical or different halogens, with the further proviso that at least two halogens are other than fluorine; and R1 and R2 are halogens, alkyls, aryls or nitriles.
- 2. The process according to claim 1, wherein the chlorination step is carried out at a temperature of between 0 and 150° C.
- 3. The process according to claim 2, wherein the temperature is of between 20 and 120° C.
- 4. The process according to claim 1, wherein the chlorination step is carried out at atmospheric pressure or under autogenous pressure.
- 5. The process according to claim 1, wherein chlorine is gradually added by sparging into the medium.
- 6. The process according to claim 1, wherein chlorine is stoichiometrically added in excess so that the medium always remains chlorinating.
- 7. The process according to claim 5, wherein, as soon as sparging of chlorine ceases, the medium is suddenly cooled.
- 8. The process according to claim 7, wherein cooling is carried out, at least partially, by removing the hydrofluoric acid under reduced pressure.
- 9. The process according to claim 1, wherein the aniline precursor is the para-trifluoromethylaniline and the aniline compound chlorinated on the ring so obtained is the ortho-ortho′-dichloro-para-trifluoromethylaniline.
Priority Claims (1)
Number |
Date |
Country |
Kind |
00 02628 |
Mar 2000 |
FR |
|
Parent Case Info
This application is an application under 35 U.S.C. Section 371 of International Application No. PCT/FR01/00578 filed on Feb. 28, 2001.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/FR01/00578 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO01/64623 |
9/7/2001 |
WO |
A |
US Referenced Citations (4)