Claims
- 1. A compound of the formula ##STR14## in which: Z represents a halogen or a cyano, acetyl, trifluoro-acetyl, nitro, C.sub.1 -C.sub.4 alkylthio, carboxyl, phosphono, dialkoxyphosphonyl or alkoxycarbonyl group, the alkylthio and alkoxy groups containing from 1 to 3 carbon atoms;
- R.sub.1 denotes a hydroxyl group and R.sub.2 represents hydrogen, or R.sub.1 and R.sub.2 taken together form an additional bond between the carbon atoms by which they are carried; and
- R.sub.3 represents
- a group --S--R.sub.5, in which R.sub.5 represents a C.sub.1 -C.sub.4 alkyl group, a C.sub.3 -C.sub.7 cycloalkyl or a phenyl group which is unsubstituted or monosubstituted or disubstituted by a halogen, a nitro group, a C.sub.1 -C.sub.4 alkyl group, a trifluoromethyl group, an amino group, a group --N--(Alk).sub.2, a group --COOAlk or a group --OAlk, Alk denoting a C.sub.1 -C.sub.4 alkyl group; or R.sub.5 denotes a group --AlkN--(Alk).sub.2 in which Alk is as defined above; or
- a group SO.sub.2 R.sub.5, in which R.sub.5 is as defined above;
- or the salts which the compounds of formula (I) are capable of producing with pharmaceutically acceptable acids when the substituent R.sub.3 comprises an amino group.
- 2. A compound as claimed in claim 1, which is 4-(4-chlorophenylthio)-6-cyano-2,2-dimethyl-2H-chromene.
- 3. An antidepressant pharmaceutical composition having weak or no activity on the cardiovascular system comprising an effective amount of the compound of claim 1 in admixture with a pharmaceutically acceptable excipient.
- 4. A method for the treatment of depressive states in mammals while at the same time having weak or no activity on the cardiovascular system of said mammal, which comprises administering to said mammal an antidepressant effective amount of a compound of formula (I) according to claim 1 or a pharmaceutically acceptable salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
88 15284 |
Nov 1988 |
FRX |
|
Parent Case Info
This application is a division of application Ser. No. 07/440,090, filed Nov. 22, 1989, now U.S. Pat. No. 5,082,858.
US Referenced Citations (5)
Divisions (1)
|
Number |
Date |
Country |
Parent |
440090 |
Nov 1989 |
|