Claims
- 1. A chromogenic thiol indicating benzoisothiazolone having the structure: ##STR29## wherein at least one of R.sup.1 and R.sup.2 is phenylazo; 4-hydroxyphenylazo; 4-nitro-2-methylphenylazo; 2-hydroxy-1-naphthylazo; 2-hydroxy-5-methylphenylazo; 2-hydroxy-4-methyl-5-nitrophenylazo; 4-hydroxy-1-naphthlazo; 4-hydroxy-3-methyl-1-naphthylazo; 4-hydroxy-5-aza-1-naphthylazo; 2-amino-1-naphthyl-azo; 1-hydroxy-2-naphthlazo; 3-N,N-dimethylaminopropylcarboxyamido-1-hydroxy-4-naphthylazo; 1-hydroxy-4-methoxy-2-naphthylazo; 2-hydroxy-3-carboxy-1-naphthylazo; 1-hydroxy-3,6-disulfonate-2-naphthylazo; 2,3-dihydroxy-1-naphthylazo; 2-hydroxy-3,5-dimethyl-1-phenylazo; benzylideneamino or 2,4-dinitro-benzylideneamino and one of R.sup.1 and R.sup.2 may be hydrogen; and
- R.sup.3 is a member of the group consisting of a carboxyalkyl, carboxyaryl or carboxyheteroaryl covalently linked to polyethylene glycol, hexathylene glycol, chitosan, polyalkylamine, aminodextran, polyethyleneimine, polylysine or aminostyrene, in which the alkyl group has 1 to 6 carbon atoms and the aryl group is phenyl or naphthyl; an aminoalkyl or aminoaryl covalently linked to polyepichlorohydrin, chloromethylpoplystyrene, polyvinylalcohol or polyvinylpyridine, in which the aryl group has 1 to 6 carbon atoms and the aryl group is phenyl or naphthyl; and an aminoalkyl, hydroxyalkyl, aminoaryl or hydroxyaryl linked to polyacrylic acid, polymethacrylic acid, polyitaconic acid, oxidized polyethylene oxide, poly(methylmethacrylate/methacrylic acid), carboxymethyl cellulose, carboxymethyl agarose or carboxymethyldextran, in which the alkyl group has 1 to 6 carbon atoms and the aryl group is phenyl or naphthyl.
- 2. The chromogenic thiol indicating benzoisothiazolone of claim 1 in which R.sup.3 is 17-amino-3,6,9,12,15-pentaoxyheptadecyl.
- 3. The chromogenic thiol indicating benzoisothiazolone of claim 1 in which R.sup.3 is N-17-(chloroacetamido)-3,6,9,12,15-pentaoxyheptadecyl.
Parent Case Info
This is a division of application Ser. No. 546,703, filed on Jul. 2, 1990, U.S. Pat. No. 5,130,433, which application is a continuation of Ser. No. 214,426, filed Jul. 1, 1988, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3707532 |
Artz et al. |
Dec 1972 |
|
3812138 |
Heise et al. |
May 1974 |
|
3878189 |
Coates et al. |
Apr 1975 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0336525 |
Apr 1959 |
CHX |
Divisions (1)
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Number |
Date |
Country |
Parent |
546703 |
Jul 1990 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
214426 |
Jul 1988 |
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