Claims
- 1. A composition for inhibiting aldose reductase comprising a pharmaceutically acceptable carrier and a chromone derivative or a pharmaceutically acceptable salt thereof represented by Formula (I): ##STR9## wherein R.sub.1 is selected from the group consisting of ethyl and a branched alkyl group represented by Formula II: ##STR10## wherein R.sub.8 and R.sub.9 are each selected from the group consisting of methyl and ethyl; R.sub.2 is selected from the group consisting of a hydrogen atom, methyl, ethyl, and a branched alkyl group represented by Formula II; R.sub.3 represents a sulfur atom; R.sub.4 is selected from the group consisting of a hydrogen atom and a lower alkoxy group; and R.sub.7 represents a phenyl group which is substituted by a hydroxy group, a a glycyloxy group, .beta.-aspartyloxy or a 4-(4-methylpiperazinomethyl)-benzoyloxy group.
- 2. A composition for inhibiting aldose reductase according to claim 1 wherein R.sub.1 is selected from the group consisting of ethyl and a branched alkyl group represented by Formula (II): ##STR11## wherein R.sub.8 and R.sub.9 are each selected from the group consisting of methyl and ethyl; R.sub.2 is selected from the group consisting of a hydrogen atom, methyl, ethyl, and a branched alkyl group represented by Formula (II); and R.sub.7 represents a phenyl group substituted by hydroxy.
- 3. A composition for inhibiting aldose reductase comprising a pharmaceutically acceptable carrier and a chromone derivative or a pharmaceutically acceptable salt thereof selected from the group consisting of 5,7-diisopropoxy-2-(4-hydroxyphenylthio)-6-methoxychromone, 5,7-diethoxy-2-(4-hydroxyphenylthio)-6-methoxychromone, 5,7-di-s-butoxy-2-(4-hydroxyphenylthio)-6-methoxychromone, 7-s-butoxy-2-(4-hydroxyphenylthio)-5-isopropoxy-6-methoxychromone, 5-ethoxy-2-(4-hydroxyphenylthio)-7-isopropoxy-6-methoxychromone, 5-hydroxy-2-(4-hydroxyphenylthio)-7-isopropoxy-6-methoxychromone, 5,6-dimethoxy-2-(4-hydroxyphenylthio)-7-isopropoxychromone, 7-s-butoxy-5,6-dimethoxy-2-(4-hydroxyphenylthio)chromone, 5,6-dimethoxy-7-(1-ethylpropoxy)-2-(4-hydroxyphenylthio)chromone and 5,7-diisopropoxy-2-(4-hydroxyphenylthio) chromone.
- 4. A composition for inhibiting aldose reductase according to claim 1 comprising as an effective component a pharmaceutically acceptable acid addition salt of a compound of Formula (I) wherein R.sub.7 represents a phenyl group which is substituted by a glycyloxy group, .beta.-aspartyloxy,
- or a 4-(4-methylpiperazinomethyl)benzoyloxy group.
- 5. A composition for inhibiting aldose reductase comprising a pharmaceutically acceptable carrier and a chromone derivative or a pharmaceutically acceptable salt thereof selected from the group consisting of 5,6-dimethoxy-2-(4-glycyloxyphenylthio)-7-isopropoxychromone hydrochloride, 5-ethoxy-2-(4-glycyloxyphenylthio)-7-isopropoxy-6-methoxychromone hydrochloride, 7-(1-ethylpropoxy)-5,6-dimethoxy-2-(4-glycyloxyphenylthio)chromone hydrochloride, 2-(4-.beta.-aspartyloxyphenylthio)-5-ethoxy-7-isopropoxy-6-methoxychromone hydrochloride, 5,6-dimethoxy-7-(1-ethylpropoxy)-2-{4-[4-(4-methylpiperazinomethyl)benzoyloxy]phenylthio}chromone dihydrochloride and 7-(1-ethylpropoxy)-5-hydroxy-2-4-[4-(4-methylpiperazinomethyl)henzoyloxy]phenylthio}-6methoxychromone dihydrochloride.
Priority Claims (2)
Number |
Date |
Country |
Kind |
2-330519 |
Nov 1990 |
JPX |
|
2-330520 |
Nov 1990 |
JPX |
|
Parent Case Info
This is a continuation of co-pending application Ser. No. 07/915,995 filed on Jul. 30, 1992, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4532254 |
Okuda et al. |
Jul 1985 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
54-114768 |
Sep 1979 |
JPX |
58-99414A |
Jun 1983 |
JPX |
Continuations (1)
|
Number |
Date |
Country |
Parent |
915995 |
Jul 1992 |
|