Claims
- 1. A prostaglandin analog of the formula ##STR2## wherein m is one to 5, inclusive; wherein M.sub.1 is ##STR3## wherein R.sub.5 and R.sub.6 are hydrogen or methyl, with the proviso that one of R.sub.5 and R.sub.6 is methyl only when the outer is hydrogen; wherein L.sub.1 is ##STR4## or a mixture of ##STR5## wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, being the same or different, with the proviso that one of R.sub.3 and R.sub.4 is fluoro only when the other is hydrogen or fluoro;
- Wherein R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, two, or three chloro or alkyl of one to 3 carbon atoms, inclusive, or a pharmacologically acceptable cation; and
- Wherein Z.sub.6 is
- (1) cis--CH.dbd.CH--CH.sub.2 --(CH.sub.2).sub.g --CF.sub.2 --,
- (2) cis--CH.dbd.CH--CH.sub.2 --(CH.sub.2).sub.g --CH.sub.2 --, or
- (3) cis--CH.sub.2 --CH.dbd.CH--(CH.sub.2).sub.g --CH.sub.2 --,
- wherein g is one, 2, or 3.
- 2. A compound according to claim 1, wherein M.sub.1 is ##STR6##
- 3. A compound according to claim 1, wherein M.sub.1 is ##STR7##
- 4. A compound according to claim 3, wherein m is 3.
- 5. A compound according to claim 4, wherein g is 3.
- 6. 2a,2b-Dihomo-9-deoxy-9,10-didehydro-15-epi-cis-13-PGD.sub.2, a compound according to claim 5.
- 7. A compound according to claim 4, wherein g is one.
- 8. 9-Deoxy-9,10-didehydro-15-epi-cis-13-PGD.sub.2, a compound according to claim 7.
- 9. cis-4,5-Didehydro-9-deoxy-9,10-didehydro-15-epi-cis-13-PGD.sub.1, a compound according to claim 7.
Parent Case Info
The present application is a divisional application of Ser. No. 614,242, filed Sept. 17, 1975, now issued as U.S. Pat. No. 4,016,184, on Apr. 5, 1977.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3954844 |
Colton et al. |
May 1976 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
614242 |
Sep 1975 |
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