Claims
- 1. A method for inhibiting the formation of fatty streak on the arterial endothelium in a mammal which comprises administering an effective amount of a citrus peel extract or powder thereto.
- 2. The method of claim 1, wherein the mammal is human.
- 3. The method of claim 1, wherein the citrus is tangerines, oranges, lemons or grapefruits.
- 4. The method of claim 1, wherein the effective amount of the citrus peel extract ranges from 1 to 1,000 mg/kg body weight/day.
- 5. The method of claim 1, wherein the effective amount of the citrus peel powder ranges from 1 to 1,000 mg/kg body weight/day.
- 6. The method of claim 1, wherein the citrus peel extract is prepared by extracting dried citrus peel with a solvent selected from the group consisting of water, a lower alcohol and an aqueous alkali- or alkaline earth-metal hydroxide solution.
- 7. The method of claim 6, wherein the citrus peel extract is prepared by a process including the steps of: adding 3 to 30 l of 20 to 95% ethanol to 1 kg of dried citrus peel; allowing the mixture to stand at a temperature ranging from 25 to 80° C. for a period ranging from 1 to 12 hours; filtering the resulting extract; and concentrating the filtrate to obtain the citrus peel extract.
- 8. The method of claim 6, wherein the citrus peel extract is prepared by a process including the steps of: adding 5 to 30 l of 0.1 to 2% Ca (OH)2 or NaOH to 1 kg of dried citrus peel; allowing the mixture to stand at a temperature ranging from 25 to 60° C. for a period ranging from 1 to 5 hours; filtering the resulting extract; adjusting the filtrate to a pH ranging from 4.0 to 7.0; allowing the resulting filtrate to stand at a temperature ranging from 1 to 10° C. for a period ranging from 10 to 48 hours; and, recovering and drying the resulting precipitate to obtain the citrus peel extract.
- 9. The method of claim 1, wherein the citrus peel powder is prepared by a process including the steps of: lyophilizing or drying the solid materials remaining after squeezing juice from citrus fruits; and powdering the dried materials to a particle size ranging from 50 to 250 μm.
- 10. The method of claim 1, wherein the citrus peel extract or citrus peel powder is administered in the form of a pharmaceutical composition containing an effective amount of the citrus peel extract and a pharmaceutically acceptable carrier.
- 11. The method of claim 1, wherein the citrus peel extract or citrus peel powder is administered in the form of an additive or a dietary supplement in food or beverage.
- 12. The method of claim 11, wherein the content of the citrus peel extract in the food ranges from 0.5 to 10% by weight.
- 13. The method of claim 11, wherein the content of the citrus peel powder in the food ranges from 1 to 30% by weight.
- 14. The method of claim 11, wherein the food is meats, chocolates, snacks, confectionery, pizza, foods made from cereal flour, gums, dairy products, soups, broths, pastes, ketchups, sauces, vitamin complexes or health foods.
- 15. The method of claim 14, wherein the foods made from cereal flour is breads, cakes, crackers, cookies, biscuits or noodles.
- 16. The method of claim 11, wherein the beverage is dairy products, vegetable juices, fruit juices, teas, alcoholic beverages or carbonated beverages.
- 17. The method of claim 11, wherein the content of the citrus peel extract in the beverage ranges from 10 to 100 g per 1,000 ml of the beverage.
Priority Claims (5)
Number |
Date |
Country |
Kind |
97-55580 |
Oct 1997 |
KR |
|
98-10888 |
Mar 1998 |
KR |
|
98-11450 |
Apr 1998 |
KR |
|
98-12411 |
Apr 1998 |
KR |
|
98-13283 |
Apr 1998 |
KR |
|
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application is a continuation-in-part application of co-pending U.S. Ser. No. 09/181,396 filed on Oct. 28, 1998.
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09181396 |
Oct 1998 |
US |
Child |
09751101 |
Dec 2000 |
US |