TREA

CL 1565 antibiotic compounds

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Information

  • Patent Grant
  • 4578383
  • Patent Number
    4,578,383
  • Date Filed
    Monday, July 2, 1984
    40 years ago
  • Date Issued
    Tuesday, March 25, 1986
    38 years ago
Information
Abstract
Novel phosphorus containing antibiotic compounds that are antitumor agents designated CL 1565-A, CL 1565-B, CL 1565-T and their salts, a process for the production and the method of using said compounds, and pharmaceutical compositions containing various salts of the compounds of the invention alone or in combination with other antitumor agents in the treatment of microbial infections and neoplastic diseases, are provided.
Description
Claims
  • 1. A phosphorus containing antibiotic compound selected from pharmaceutically acceptable salts of the compounds designated CL 1565-A, CL 1565-B, and CL 1565-T, having the structural formulas 1, 2a, and 2b, respectively, ##STR3##
  • 2. A compound according to claim 1 which is a pharmaceutically acceptable salt of CL 1565-A compound.
  • 3. A compound according to claim 1 which is a pharmaceutically acceptable salt of CL 1565-B compound.
  • 4. A compound according to claim 1 which is a pharmaceutically acceptable salt of CL 1565-T compound.
  • 5. A pharmaceutical composition comprising an antimicrobially effective amount of at least one pharmaceutically acceptable salt of CL 1565-A, CL 1565-B, or CL 1565-T, according to claim 1 and a pharmaceutically acceptable carrier.
  • 6. A compound according to claim 1 which is CL 1565-A, sodium salt.
  • 7. A compound according to claim 1 which is CL 1565-B, sodium salt.
  • 8. A compound according to claim 1 which is CL 1565-T, sodium salt.
  • 9. A compound according to claim 1 which is CL 1565-A, calcium salt.
  • 10. A compound according to claim 1 which is CL 1565-A, barium salt.
CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation-in-part of copending application Ser. No. 447,544 filed Dec. 7, 1982 (now abandoned) which is a continuation-in-part of application Ser. No. 439,973 filed Nov. 8, 1982 (now abandoned), which is a continuation-in-part of application Ser. No. 351,704 filed Feb. 24, 1982 (now abandoned).

US Referenced Citations (1)
Number Name Date Kind
4239751 Coronelli et al. Dec 1980
Continuation in Parts (3)
Number Date Country
Parent 447544 Dec 1982
Parent 439973 Nov 1982
Parent 351704 Feb 1982