CLASSIFICATION TREE (CART) SOFTWARE FOR CANCER STUDIES

Information

  • Research Project
  • 2545368
  • ApplicationId
    2545368
  • Core Project Number
    R44CA065338
  • Full Project Number
    5R44CA065338-03
  • Serial Number
    65338
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/15/1994 - 31 years ago
  • Project End Date
    9/29/1998 - 27 years ago
  • Program Officer Name
    ERICKSON, BURDETTE (BUD) W
  • Budget Start Date
    9/30/1997 - 28 years ago
  • Budget End Date
    9/29/1998 - 27 years ago
  • Fiscal Year
    1997
  • Support Year
    3
  • Suffix
  • Award Notice Date
    9/15/1997 - 28 years ago
Organizations

CLASSIFICATION TREE (CART) SOFTWARE FOR CANCER STUDIES

Our goals are to provide enhancements to Classification and Regression Tree (CART) software (Breiman, Freidman, Olshen and Stone, 1984), in SYSTAT and SAS, including: (1) a complete graphical interface (2) tree- editing of splits and manual tree pruning and grafting; (3) standard statistical and modeling procedures for all case's in a node, (4) diagnostic reports including instability among cross-validation trees; and confidence intervals of variable importances; (5) Breiman's within- node error measure, Olshen's massively repeated cross-validation for node specific measures, optional averaging of 5.10 repeated cross-validation runs for overall error; (6) Boolean ( logical "and/or" compound splitting) rules; (7) Friedman's numerically superior linear combination splits; (8) algorithms for censored survival data (9) and serially dependent observations; (10) Breiman's Bootstrap Aggregation predictors; a consensus of trees grown on bootstrapped samples improving accuracy; (11) Breiman's probabilistic splitting; produces a probability distribution over terminal nodes for each observation; (12) split revisiting -- trees improved by reoptimizing a parent split holding child splits fixed; yielding better performing and/or smaller trees; (13) automatic missing value imputation and multivariate outlier detection; (14) faster running times and a version for multiple CPU platforms; (15) tutorial materials. PROPOSED COMMERCIAL APPLICATION: By allowing CART to be used by most levels of analyst on all major computing platforms in SAS and SYSTAT, we anticipate a market including users in all areas of biomedical research. We expect to ship for desktop and single user workstations as well as research mainframes and mini-computers world-wide, including University and Government Computing Centers, hospital research centers, and pharmaceutical companies. As we already have over 100 mainframe SAS sites and thousands of SYSTAT PC sites we anticipate excellent acceptance of enhanced CART products.

IC Name
NATIONAL CANCER INSTITUTE
  • Activity
    R44
  • Administering IC
    CA
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    393
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    ZRG7
  • Study Section Name
  • Organization Name
    SALFORD SYSTEMS
  • Organization Department
  • Organization DUNS
  • Organization City
    SAN DIEGO
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    92120
  • Organization District
    UNITED STATES