Clot retrieval devices

Description

FIELD OF THE INVENTION

The present invention relates generally to the field of distal mechanical thrombectomy, more particularly, to a self-expandable mechanical clot retrieval device used in the treatment of acute ischemic stroke and pulmonary embolism in a patient. The retrieval device is of extremely small size delivered through an intravascular microcatheter and meticulously designed to remain in a collapsed state while advancing through the microcatheter to remove thrombus or embolus from the blocked arteries.

DISCUSSION OF THE PRIOR ART

Acute ischemic stroke remains one of the major causes of death and disability worldwide. It refers to stroke caused by thrombosis or embolism creating an acute blockage in vasculature that stops flow of blood and deprives the surrounding brain tissue of oxygen. In the absence of oxygen, the brain cells of the immediate area begin to die and release a cascade of toxic chemicals that threaten brain tissue in the surrounding area.

Similarly, pulmonary embolism is a common and potentially fatal condition, creating a sudden blockage in a lung artery caused by any naturally occurring embolus traveling through the arteries of the lung and occluding a small artery that stops the flow of blood and deprives the surrounding lung tissue of oxygen. In the absence of oxygen, the lung tissues in the immediate area succumb to lysis as they are unable to process sufficient oxygen into the blood.

Importantly, both acute ischemic stroke and pulmonary embolism can be avoided and treated by removing the acute blockage and restoring blood flow to the affected area. In recent years, significant advances have been made to prevent ischemic stroke and pulmonary embolism through endovascular procedures involving the use of distal mechanical clot retrieval devices on the end of catheters to manually retract clot and fragments of clot.

Generally, the distal mechanical devices are delivered endovascularly and advanced by guidewire and microcatheter until the device is located distal of the clot where it expands. Thus force is applied to the distal surface of the clot to dislodge it from the artery wall where it is caught and retracted proximally by the retrieval device.

Despite continuous advances made in the art of distal mechanical thrombectomy, there is still much room for improvement in effectively removing acute blockage particularly in engaging and retracting thrombus or embolus from extremely small vasculature. The present invention is an efficient and meticulous approach to improve upon the distal mechanical thrombectomy.

SUMMARY OF THE INVENTION

Various aspects of the present invention concern a self-expandable mechanical clot retrieval device that effectively and reliably removes thrombus or embolus from blocked vasculature. It is designed variously to dislodge, engage and retract blood clot from extremely small and tortuous vasculature. The retrieval device comprises an elongate member and a plurality of ring elements. The ring elements may comprise a plurality of struts and crowns interconnected by a tether formed at a distal end of the elongate member or may be a separate component attached thereto. In one aspect, at least one tether connects each ring element to the elongate member to restrain the ring element in a collapsed configuration during delivery of the retrieval device through an intravascular microcatheter. The tether connecting the ring element to the elongate member disengages when the retrieval device is positioned at the occluded site and the microcatheter is retracted to allow the self-expandable ring elements to reach an expanded configuration. Preferably, the self-expandable ring elements are formed of shape memory material such as Nitinol.

Additional aspects of the present invention concern methods of using the mechanical clot retrieval device described in the previous paragraph. It is used in the treatment of acute ischemic stroke and pulmonary embolism in a patient. The method of removing the blood clot from a blocked artery includes advancing a self-expandable mechanical clot retrieval device having an elongate member and a plurality of self-expandable ring elements arranged at a distal end of the elongate member through the vasculature to a blockage site in the artery. The retrieval device bypasses the clot and is positioned distal to the clot to allow the self-expandable ring elements to reach an expanded configuration in order to engage the clot within expanded ring elements and is proximally retracted from the artery. The method may include retracting the expanded ring elements proximally into a guide catheter or a microcatheter.

STATEMENT OF THE INVENTION

In a first embodiment of the invention the clot retrieval device comprises an elongate member and a plurality of clot engaging elements at a distal end of the elongate member, the clot engaging elements being self expandable and having a retracted delivery configuration and an expanded deployed configuration; and a biasing element for biasing the clot engaging elements into a retracted delivery configuration against the elongate member; the biasing element being releasable to allow the clot engaging elements to expand into the deployed configuration.

The second embodiment of the invention comprises a method of retrieving a clot comprising the steps of: (1) providing an elongate member and a plurality of clot engaging elements at a distal end of the elongate member, the clot engaging elements having a retracted configuration and an expanded configuration: (2) providing a biasing element for retaining the clot engaging elements in the retracted configuration; (3) advancing a microcatheter across a clot; (4) advancing the elongate member with the clot engaging elements in a retracted configuration through the microcatheter so that at least some of the clot engaging elements are distal of the clot; (5) releasing the biasing so that the clot engaging elements expand to the expanded configuration; (6) engaging the clot engaging elements with a clot; and (7) using the clot engaging elements, drawing the clot into a retrieval element.

A third embodiment of the invention comprises a luminal prosthesis device comprising: an elongate member and a plurality of luminal prosthetic elements at a distal end of the elongate member; the luminal prosthetic elements being self expandable and having a retracted delivery configuration and an expanded deployed configuration; and a biasing element for biasing the luminal prosthetic elements into a retracted delivery configuration against the elongate member; the biasing element being releasable to allow the luminal prosthetic elements to expand into the deployed configuration.

A fourth embodiment of the invention comprises a clot retrieval device comprising: an elongate member and a plurality of clot engaging elements at a distal end of the elongate member, the clot engaging elements being self expandable and having a retracted delivery configuration, a retracted deployed configuration and a fully expanded configurations; and providing a release element for biasing the clot engaging elements in at least one retracted configuration; activation of the release element allowing the clot engaging elements to expand into the fully expanded configuration.

In one variation of this embodiment the diameter of the clot engagement elements in the retracted delivery configuration is smaller than the diameter of the clot engagement elements in the retracted deployed configuration and the diameter of the clot engagement elements in the retracted deployed configuration is smaller than the diameter of the clot engagement elements in the fully expanded configuration.

In another variation of this embodiment a release element is configured to bias the clot engaging elements in a retracted deployed configuration. The release element may be integral with the clot engagement elements. The release element may be integral with elongate member. The release element may be connected to either the clot engagement elements, the elongate member or to both. The release element may comprise; a snap element, a restraining element, a tether, an interlocking element, an overlapping element of the clot engagement element, an abutment element, a connector element, a housing element, a pair of interacting elements, or a limiting element configured to limit at least one degree of expansion movement.

In another variation of this embodiment the clot engagement element comprises a plurality of struts and said release element is configured to limit relative movement between at least a pair of said struts. In another variation of this embodiment the release element is configured to limit relative movement between the clot engagement element and the elongate member. The elongate member may be configured to activate the release element.

In another variation of this embodiment the device comprises an activation element said activation element configured to affect the release of the release element. The activation element may comprise an elongate tube, an elongate member, or a tether.

A fifth embodiment of the invention comprises a clot retrieval device comprising: an elongate member and a first clot engaging element and a second clot engaging element the first clot engaging element distal of the second clot engaging element, the clot engaging elements being self expandable and having a sheathed delivery configuration, a deployed configuration and a fully expanded configurations; and providing at least one release element for biasing the clot engaging elements in the deployed configuration; activation of the at least one release element allowing the clot engaging elements to expand into the fully expanded configuration.

In one variation of this embodiment the sheathed configuration comprises sheathing within the lumen of a microcatheter. In another variation of this embodiment the unsheathing the clot engaging elements allows the clot engaging elements to assume the unsheathed configuration. In another variation of this embodiment the diameter of the clot engaging elements in the deployed configuration is greater than the diameter of the clot engaging elements in the sheathed configuration. In another variation of this embodiment the first clot engagement element assumes the expanded configuration while the second clot engaging element is in the deployed configuration.

A sixth embodiment of the invention comprises a method for retrieval of a clot comprising the steps of: (1) providing a clot retrieval device the clot retrieval device comprising an elongate member and a plurality of clot engaging elements at a distal end of the elongate member, the clot engaging elements having a retracted configuration, a partially expanded configuration and an expanded configuration; (2) providing a biasing element for limiting the expansion of the clot engaging elements; (3) advancing a microcatheter across a clot; (4) advancing the elongate member with the clot engaging elements in a retracted configuration through the microcatheter so that at least some of the clot engaging elements are distal of the clot; (5) retracting the microcatheter so as to unsheathe at least one clot engaging element, (6) activating the biasing element so as to trigger the expansion of at least one of said clot engagement elements to the expanded configuration, (7) retracting the clot retrieval device and the clot into a proximal retrieval element.

In one variation of this embodiment the method comprises the step of retracting the microcatheter also comprises the step of expanding the at least one clot engagement element to the partially expanded configuration. In another variation of this embodiment the step of activating the biasing element comprises the step of applying an activation force to the biasing element.

In another variation of this embodiment the step of activating the biasing element comprises the step of applying a compressive, tensile, twisting or radial force to the biasing element.

In another variation of this embodiment the method comprises the step of providing a plurality of clot engagement elements configured such that in the partially expanded configuration a flow lumen extends through the centre of said clot engagement elements, said lumen being larger than the diameter of the microcatheter and smaller than the diameter of the vessel.

In another variation of this embodiment the method comprises the step of holding the clot retrieval device steadfast in the vessel for a dwell time period the dwell time period comprising at least one minute.

A seventh embodiment of the invention comprises a retrieval device for removing occlusive clot from the vasculature the retrieval device comprising: an elongate member and an expandable body connected to the elongate member, the expandable body comprising a plurality of self-expanding clot engaging elements, each clot engaging element comprising a plurality of struts and a plurality of crowns arranged to form at least one ring, at least one of said plurality of crowns comprising an integral connection to an adjacent ring, a spacing between at least two of said clot engaging elements said spacing comprising a variable spacing in use.

In one variation of this embodiment the at least one integral connection comprises a monolithic connection. The at least one integral connection may comprise a connection to a crown of an adjacent ring of the same clot engaging element. The at least one integral connection may comprise a connection to a crown of a ring of an adjacent engaging element. The at least one integral connection may comprise a connection to the elongate member. In another variation of this embodiment the at least one of said plurality of crowns comprises an unconnected crown.

In another variation of this embodiment the a pair of adjacent crowns of said expandable body comprise a pair of unconnected crown, the first of said pair of adjacent crowns comprising a proximally facing crown and the second of said pair of adjacent crowns comprising a distally facing crown. The first crown of said pair of adjacent crowns may be located on a first clot engaging element and the second crown of said pair of adjacent crowns may be located on a second clot engaging element.

In another variation of this embodiment the clot engaging elements are arranged in series. In another variation of this embodiment the clot engaging elements are arranged in series.

In another variation of this embodiment the clot engagement elements are spaced apart. The spacing between at least two of said clot engaging elements may vary during delivery. The spacing between at least two of said clot engaging elements may vary during engagement with the clot. The spacing between at least two of said clot engaging elements may vary during clot disengagement with the vessel wall. The spacing between at least two of said clot engaging elements may vary during withdrawal of the clot through the vasculature. The spacing between at least two of said clot engaging elements may vary during removal of the clot and device into the lumen of a retrieval catheter. The spacing between at least two of said clot engaging elements may vary across the diameter of the clot engaging elements.

An eighth embodiment of the invention comprises a retrieval device for removing occlusive clot from the vasculature comprising: an elongate member and an expandable body connected to the elongate member, the expandable body comprising an collapsed delivery configuration and an expanded configuration, the expandable body comprising a plurality of self-expanding clot engaging elements, cut from a tube in a monolithic structure, each clot engaging element comprising a plurality of struts and a plurality of crowns arranged to form a ring, at least one pair of adjacent clot engaging elements being spaced apart by a plurality of connector elements, the pair of adjacent clot engaging elements and the plurality of connectors configured to create a plurality of clot engaging cells, the plurality of connectors comprising a plurality of helical strut.

In one variation of this embodiment the plurality of clot engaging cells are configured to scaffold outwardly so as to create a flow lumen through the clot. The plurality of clot engaging cells may be configured to urge clot ingress through the cell openings so that the clot is interlaced with the plurality of engaging cells.

In another variation of this embodiment the helical struts extend circumferentially through an angle of at least 25 degrees. In another variation of this embodiment the helical struts extend circumferentially through an angle of at least 40 degrees. In another variation of this embodiment the helical struts extend circumferentially through an angle of at least 50 degrees. In another variation of this embodiment the helical struts extend axially a distance of at least 500 micrometers. In another variation of this embodiment the helical struts extend axially a distance of at least 750 micrometers. In another variation of this embodiment the helical struts extend axially a distance of at least 900 micrometers.

In another variation of this embodiment the tube from which the expandable body is cut has a diameter larger than the diameter of the expandable body in the collapsed delivery configuration. The tube from which the expandable body is cut may have a diameter equal to or smaller than the expanded diameter of the expandable body.

A ninth embodiment of the invention comprises a mechanical clot retrieval device for use in a blood artery, comprising an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration inside the artery, wherein the ring elements comprise a radial force biasing ring elements toward an expanded configuration, wherein the radial force is absorbed by the elongate member in the collapsed configuration, wherein the microcatheter is retracted proximally allowing the ring elements reach the expanded configuration.

In one variation of this embodiment each strut comprises a crown element. The crown element may comprise an engagement member and a fixed tab. The crown element may comprise an engagement member and an engagement hook. The crown element may comprise an engagement member and a connector. The crown element may comprise an engagement member and an engagement tab. The crown element may engage a neighboring crown element in a snap-fit mechanism.

In another variation of this embodiment the snap-fit mechanism restrains the ring elements in the collapsed configuration. The ring elements in the collapsed configuration may be substantially parallel along the longitudinal axis of the elongate member. In another variation of this embodiment the device comprises a proximal fixed collar configured proximally of the ring elements. In another variation of this embodiment the device further comprises a push tube attached to the proximal fixed collar.

In another variation of this embodiment the device further comprises a distal moveable collar configured distally of the ring elements. In another variation of this embodiment the device comprises a balloon. In another variation of this embodiment the balloon is delivered in a deflated state. In another variation of this embodiment the device further comprises a ball element. In another variation of this embodiment the device further comprises a pair of pull tethers having distal and proximal ends. In another variation of this embodiment the distal ends are connected to the most proximal ring element. In another variation of this embodiment the distal ends are attached to the connector. In another variation of this embodiment the distal ends are attached to the engagement tab.

In another variation of this embodiment the distal ends are attached to the distal movable collar. In another variation of this embodiment the proximal ends extend exterior of the artery. The proximal ends may be manually pulled proximally to disengage the snap-fit mechanism. The proximal ends may be attached to the elongate member. In another variation of this embodiment the balloon is inflated to disengage the snap-fit mechanism. In another variation of this embodiment the ball element is manually retracted proximally to disengage the snap-fit mechanism.

A tenth embodiment of the invention comprises a mechanical clot retrieval device for use in an artery, comprising an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is attached to the elongate member by connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by the elongate member in the collapsed configuration, wherein the microcatheter is retracted proximally allowing the ring elements to reach the expanded configuration.

In one variation of this embodiment each strut comprises a crown element. In another variation of this embodiment the proximally facing crown element is a ring proximal crown and distally facing crown element is a ring distal crown. The ring proximal crown may be attached to the elongate member by connecting tethers. The crown element may be engaged with the elongate member in a snap-fit mechanism. The snap-fit mechanism restrains the ring elements in the collapsed configuration. The elongate member is manually retracted to disengage the snap-fit mechanism. In another variation of this embodiment the elongate member is attached to at least one ring element in the expanded configuration.

A eleventh embodiment of the invention comprises a mechanical clot retrieval device for use in an artery, comprising an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element comprising a plurality of struts is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

In one variation of this embodiment each strut comprises a crown element. The crown element may be attached to the elongate member by a bonding agent. The bonding agent restrains the ring elements in the collapsed configuration. The bonding agent may be dissolved in vivo allowing the ring elements reach the expanded configuration. The radial force may be absorbed by the bonding agent.

In another variation of this embodiment the crown element is attached to the elongate member by a resorbable covering. The re-absorbable covering restrains the ring elements in the collapsed configuration. The re-absorbable covering may be dissolved in vivo allowing the ring elements to reach the expanded configuration. The radial force may be absorbed by the re-absorbable covering. In another variation of this embodiment the device comprises a pair of pull tethers having distal and proximal ends. The distal ends of said tethers are attached to most the proximal ring element. The proximal ends of said tethers extend exterior of the artery.

An twelfth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an elongate member having a distal end, a proximal end and a plurality of radial pins, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is advanced through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by radial pins in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

In one variation of this embodiment the radial pin has an engagement member. In another variation of this embodiment each strut comprises a crown element. The crown element may comprise a plurality of eyelets. In another variation of this embodiment the distally facing eyelet engages with the radial pin. The distally facing eyelet may fasten the ring elements to the elongate member.

In another variation of this embodiment the proximally facing eyelet engages with the radial pins in a snap-fit mechanism. In another variation of this embodiment the snap-fit mechanism restrains the ring elements in the collapsed configuration. In another variation of this embodiment the engagement member is dissolved in vivo to disengage the snap-fit mechanism. In another variation of this embodiment the engagement member is dissolved in vivo allowing the ring elements to reach the expanded configuration.

An thirteenth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an elongate member having a distal end, a proximal end, an outer tube having a plurality of slots and a retractable inner core wire, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by the inner core wire in the collapsed configuration, wherein the microcatheter is retracted proximally allowing the ring elements to reach the expanded configuration.

In one variation of this embodiment each strut comprises a crown element having an eyelet. In another variation of this embodiment a tether is advanced out of the slot to loop through the eyelet and folds back into the slot to loop around the retractable inner core wire. The tether may engage the ring elements with the elongate member in a tether-loop mechanism. In another variation of this embodiment the tether-loop mechanism restrains the ring elements in the collapsed configuration.

In another variation of this embodiment the retractable inner core wire is manually retracted proximally to disengage the tether-loop mechanism. The retractable inner core wire may be advanced out of each slot to loop through each eyelet and folds back into the slot to loop inside the outer tube. The retractable inner core wire may engage the ring elements with the elongate member in a tether-loop mechanism.

In another variation of this embodiment the tether-loop mechanism restrains the ring elements in the collapsed configuration. In another variation of this embodiment the retractable inner core wire is manually retracted proximally to disengage the tether-loop mechanism.

An fourteenth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an elongate member having a distal end, a proximal end and a tube lumen having a plurality of slots, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the microcatheter is retracted proximally allowing the ring elements to reach the expanded configuration.

In one variation of this embodiment each strut comprises a crown element having an eyelet. In another variation of this embodiment the device further comprises a plurality of tethers, having distal ends that extend interior of the tube lumen and proximal ends that extend exterior of the artery. Each tether may be advanced through a slot to loop around the eyelet and folded back into the slot attached to the distal end of the elongate member. Each tether may engage the ring elements with the elongate member in a tether-loop mechanism. The tether-loop mechanism may restrain the ring elements in the collapsed configuration. Each tether may be broken to disengage the snap-fit mechanism allowing ring elements to reach the expanded configuration.

An fifteenth embodiment of the invention comprises a mechanical clot retrieval device for use in a blood artery, comprising an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a proximal collar attached to an abutment tube; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is attached to the elongate member by connecting tethers and is advanced through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

In one variation of this embodiment each strut comprises a crown element. In another variation of this embodiment the device further comprises a plurality of tethers. Each tether may be looped around the ring element and is attached to the elongate member.

Each tether may engage the ring elements with the elongate member in a tether-loop mechanism. The radial force may be absorbed by the tether-loop mechanism. The tether-loop mechanism may restrain the ring elements in the collapsed configuration. In another variation of this embodiment the elongate member may be manually retracted proximally to disengage the tether-loop mechanism.

A sixteenth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a plurality of collars configured at the distal end of the elongate member; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element is configured between two collars, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by the collars in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements reach the expanded configuration.

In one variation of this embodiment the collar is bevel shaped or the collar is recess shaped or the collar is a shaped engagement collar or the collar has a plurality of holes or the collar has a plurality of dove tail grooves.

In one variation of this embodiment each strut comprises a crown element. In one variation of this embodiment the crown element has a tab extending axially and radially inward. The crown element may have a pin extending axially and radially inward. The crown element may have a shaped tab extending axially and radially inward and the tab may be bevel shaped. The tab may be square shaped. The tab may engage with the collar in a collar mechanism.

In another variation of this embodiment the collar mechanism engages the ring elements with the elongate member. The collar mechanism may restrain the ring elements in the collapsed configuration. In another variation of this embodiment the elongate member is manually retracted proximally to disengage the collar mechanism.

In another variation of this embodiment the pin engages with the hole in a collar mechanism. In another variation of this embodiment the collar mechanism engages the ring elements with the elongate member. In another variation of this embodiment the collar mechanism restrains the ring elements in the collapsed configuration. In another variation of this embodiment the elongate member is manually retracted proximally to disengage the collar mechanism.

In another variation of this embodiment the shaped tab engages with the dove tail groove in a collar mechanism. In another variation of this embodiment the collar mechanism engages the ring elements with the elongate member. In another variation of this embodiment the collar mechanism restrains the ring elements in the collapsed configuration. In another variation of this embodiment the elongate member is manually retracted proximally to disengage the collar mechanism.

A seventeenth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a proximal collar; and a self-expandable ring element configured at the distal end of the elongate member, wherein the ring element, comprising a plurality of struts, is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring element comprises a radial force biasing the ring element towards an expanded configuration, wherein the radial force is absorbed by the proximal collar in the collapsed configuration, wherein the microcatheter is retracted allowing the ring element to reach the expanded configuration.

In one variation of this embodiment each strut comprises a crown element having a tab extending axially and radially inward. In another variation of this embodiment the tab engages with the proximal collar in a collar mechanism. In another variation of this embodiment the collar mechanism engages the ring element with the elongate member. In another variation of this embodiment the collar mechanism restrains the ring element in the collapsed configuration. In another variation of this embodiment the elongate member is manually retracted proximally to disengage the collar mechanism.

A eighteenth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an elongate member having a distal end, a proximal end and inner lumen having a plurality of openings, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular catheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the microcatheter is retracted allowing the ring elements reach the expanded configuration.

In one variation of this embodiment each strut comprises a crown element and an engagement tab. In one variation of this embodiment the device further comprises a plurality of tethers having proximal ends extend exterior of the inner lumen. In one variation of this embodiment each tether is advanced out of each opening and is wrapped around the engagement tab in an eyelet mechanism. In one variation of this embodiment the eyelet mechanism engages the ring elements with the elongate member. In one variation of this embodiment the eyelet mechanism restrains the ring elements in the collapsed configuration.

In one variation of this embodiment the radial force is absorbed by the eyelet mechanism. In one variation of this embodiment the tethers are manually pulled proximally to disengage the eyelet mechanism.

A nineteenth embodiment of the invention comprises a mechanical clot retrieval device for use in a blood artery, comprising an elongate member having a distal end, a proximal end and a plurality of raised tabs, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements towards an expanded configuration, wherein the radial force is absorbed by the raised tabs in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

The variations described in association with each of the embodiments 1 through to 19 can be applied to the 20.sup.th through to the 36.sup.th embodiments (below) and are hereby incorporate as variations to each of the 20.sup.th through to the 36.sup.th embodiments.

A twentieth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an elongate member having a distal end, a proximal end, a plurality of engagement diameters and a plurality of disengagement diameters, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a proximal abutment tube; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by engagement diameters in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration. Each strut may comprise a crown element having a C-shaped engagement tab extending radially inward. The C-shaped engagement tab engages with the engagement diameter to restrain the ring elements along the elongate member. The C-shaped engagement tab engages with the engagement diameter to restrain the ring element in the collapsed configuration. In one variation of this embodiment proximal axial movement of the elongate member disengages the ring element at the disengagement diameter.

A twenty first embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an elongate member having a distal end, a proximal end and an inner wire, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a proximal abutment tube; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by the elongate member in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

A twenty second embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising: an elongate member having a distal end, a proximal end and an inner lumen with a plurality of slots, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a proximal collar; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by slots in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

A twenty third embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising: an elongate member having a distal end, a proximal end and a plurality of monofilaments, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a proximal collar; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements in an expanded configuration, wherein the radial force is absorbed by monofilaments in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

A twenty fourth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising: an elongate member having a distal end, a proximal end and a plurality of inactivated cuffs configured at the distal end of the elongate member, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a tube; and a plurality of self-expandable ring elements configured over the inactivated cuffs, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements comprise a radial force biasing the ring elements towards an expanded configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

A twenty fifth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a proximal collar; a bumper tube; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration; wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

A twenty sixth embodiment of the invention comprises a mechanical clot retrieval device for use vasculature, comprising: an elongate member having a distal end, a proximal end and a plurality of restraining loops configured at the distal end of the elongate member, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is connected to the restraining loop by connecting tethers, wherein the ring elements have a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by the restraining loops in a collapsed configuration.

A twenty seventh embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising: an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end that extends exterior of the artery; a bumper tube; a proximal collar; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element comprising a plurality of struts is interconnected by ring connecting tethers, wherein the ring elements comprise a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by the elongate member in a collapsed configuration.

A twenty eighth embodiment of the invention comprises a mechanical clot retrieval device for use in a tortuous vessel, comprising an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the vessel and the proximal end extends exterior of the vessel; and a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements have a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by the microcatheter in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

A twenty ninth embodiment of the invention comprises a mechanical clot retrieval device for use in a tortuous vessel, comprising an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the vessel and the proximal end extends exterior of the vessel; a plurality of self-expandable ring elements having a first diameter and a second diameter, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration; and a control strut having distal end attached to most proximal ring element and proximal end attached to the elongate member by adhesive bonds, wherein the ring elements have a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by the microcatheter in the collapsed configuration, wherein the microcatheter is retracted proximally allowing the ring elements to reach the expanded configuration.

A thirtieth embodiment of the invention comprises a mechanical clot retrieval device for use in a tortuous vessel, comprising an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the vessel and the proximal end extends exterior of the vessel; and a plurality of self-expandable ring elements, wherein each ring element, comprising a plurality of struts, is interconnected by ring connecting tethers and is delivered through an intravascular microcatheter in a collapsed configuration; and wherein the ring elements have a radial force biasing the ring elements towards an expanded configuration, wherein the radial force is absorbed by the microcatheter in the collapsed configuration, wherein the microcatheter is retracted proximally allowing the ring elements reach the expanded configuration.

A thirty first embodiment of the invention comprises a mechanical clot retrieval device for use in a tortuous vessel, comprising: an elongate member having a distal end and a proximal end, wherein the distal end extends interior of the vessel and the proximal end extends exterior of the vessel; a plurality of self-expandable ring elements configured at the distal end of the elongate member, wherein each ring element comprises a plurality of struts and is delivered through an intravascular microcatheter in a collapsed configuration; and a plurality of ring connecting tethers having distal and proximal ends, wherein the distal ends are connected to the ring element and the proximal ends are attached to the elongate member, wherein the ring elements have a radial force biasing the ring elements towards an expanded configuration, wherein the radial force is absorbed by the microcatheter in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

A thirty second embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an activation tether having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a distal collar, wherein the distal end of the activation tether is attached to the distal collar; and a plurality of self-expandable ring elements configured at the distal end of the activation tether, wherein each ring element, comprising a plurality of struts, is interconnected by bridges and is delivered through a microcatheter in a collapsed configuration, wherein the ring elements have a radial force biasing the ring elements towards an expanded configuration, wherein the radial force is absorbed by the microcatheter in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements reach the expanded configuration.

A thirty third embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an activation tether having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a distal collar, wherein the distal end of the activation tether is attached to the distal collar; and a self-expandable ring element configured at the distal end of the activation tether, wherein the ring element comprises a plurality of struts and is delivered through a microcatheter in a collapsed configuration, wherein the ring element has a radial force biasing the ring element toward the expanded configuration, wherein the radial force is absorbed by the microcatheter in the collapsed configuration, wherein the microcatheter is retracted allowing the ring element to reach the expanded configuration.

A thirty fourth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an activation tether having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a distal collar, wherein the distal end of the activation tether is attached the distal collar; a self-expandable ring element configured at the distal end of the activation tether, wherein the ring element comprises a plurality of struts and is delivered through a microcatheter in a collapsed configuration; and a pair of removal tethers having distal ends attached to the ring element and proximal ends that extend exterior of the artery, wherein the ring element has a radial force biasing the ring element towards an expanded configuration, wherein the radial force is absorbed by the microcatheter in the collapsed configuration, wherein the microcatheter is retracted allowing the ring element to reach the expanded configuration.

A thirty fifth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising an activation tether having a distal end and a proximal end, wherein the distal end extends interior of the artery and the proximal end extends exterior of the artery; a couple of collars; a couple of ring elements configured at the distal end of the activation tether, wherein each ring element comprising a plurality of struts and is delivered through a microcatheter in a collapsed configuration; and a pair of removal tethers having distal ends attached to the ring element and proximal ends attached to the collar, wherein the ring elements have a radial force biasing the ring elements toward an expanded configuration, wherein the radial force is absorbed by the microcatheter in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

A thirty sixth embodiment of the invention comprises a mechanical clot retrieval device for use in vasculature, comprising a pair of activation tethers having distal ends extending interior of the artery and proximal ends extending exterior of the artery; a distal collar, wherein distal ends of the activation tether are attached to the distal collar; and a plurality of self-expandable ring elements configured at distal ends of the activation tethers, wherein the each ring element, comprising a plurality of struts, is interconnected by bridges and is delivered through an intravascular microcatheter in a collapsed configuration, wherein the ring elements have a radial force biasing the ring elements towards an expanded configuration, wherein the radial force is absorbed by the microcatheter in the collapsed configuration, wherein the microcatheter is retracted allowing the ring elements to reach the expanded configuration.

The mechanical clot retrieval device in any of the preceding embodiments may comprise a ring element made of shape memory material. The mechanical clot retrieval device in any of the preceding embodiments may comprise a ring element is made of Nitinol. The mechanical clot retrieval device in any of the preceding embodiments may comprise a retrieval device that is made of shape memory material. The mechanical clot retrieval device in any of the preceding embodiments may comprise a retrieval device that is partly made of shape memory material.

BRIEF DESCRIPTION OF THE DRAWINGS

The invention will be more clearly understood from the following description of some embodiments thereof, given by way of example with reference to the accompanying drawings, in which:

FIG. 1a is a diagram illustrating a typical occlusive clot in a cerebral artery;

FIG. 1b is an enlarged view of a detail of FIG. 1a;

FIGS. 2a-2h are diagrams illustrating the insertion of a guidewire and the deployment of a clot retrieval device of the invention;

FIGS. 3a-3e illustrate a clot retrieval device according to one embodiment of the invention;

FIGS. 4a-4d illustrate steps involved in using the device of FIGS. 3a-3d;

FIGS. 5a-5e illustrate another clot retrieval device of the invention;

FIGS. 6a-6f illustrate a further clot retrieval device of the invention;

FIGS. 7a-7e illustrate another clot retrieval device of the invention;

FIGS. 8a-8d illustrate a further clot retrieval device of the invention;

FIGS. 9a-9d illustrate another clot retrieval device of the invention;

FIGS. 10a-10d illustrate a further clot retrieval device of the invention;

FIGS. 11a-11h illustrate another clot retrieval device of the invention;

FIGS. 12a-12c illustrate a further clot retrieval device of the invention;

FIGS. 13a-13f illustrate another clot retrieval device of the invention;

FIGS. 14a-14c illustrate a further clot retrieval device of the invention;

FIGS. 15a-15c illustrate a method for using a clot retrieval device of the invention;

FIGS. 16a-16d illustrate another method for using a clot retrieval device of the invention;

FIGS. 17a-17d illustrate a further clot retrieval device of the invention;

FIGS. 18a-18d illustrate another clot retrieval device of the invention;

FIGS. 19a-19d illustrate a further clot retrieval device of the invention;

FIGS. 20a-20b illustrate another clot retrieval device of the invention;

FIGS. 21a-21f illustrate a further clot retrieval device of the invention;

FIGS. 22a-22d illustrate a method for using a clot retrieval device of the invention;

FIGS. 23a-23c illustrate a mechanism used in a clot retrieval device of the invention;

FIGS. 24a-24c illustrate a further clot retrieval device of the invention;

FIGS. 25a-25k illustrate another clot retrieval device of the invention;

FIGS. 26a-26d illustrate a further clot retrieval device of the invention;

FIGS. 27a-27b illustrate another clot retrieval device of the invention;

FIGS. 28a-28b illustrate a further clot retrieval device of the invention;

FIGS. 29a-29h illustrate a method for using a clot retrieval device of the invention;

FIGS. 30a-30e illustrate another clot retrieval device of the invention;

FIGS. 31a-31e illustrate a further clot retrieval device of the invention;

FIGS. 32a-32d illustrate another clot retrieval device of the invention;

FIGS. 33a-33g illustrate a further clot retrieval device of the invention;

FIGS. 34a-34j illustrate another clot retrieval device of the invention;

FIGS. 35a-35b illustrate a further clot retrieval device of the invention;

FIGS. 36a-36d illustrate another clot retrieval device of the invention;

FIGS. 37a-37i illustrate a further clot retrieval device of the invention;

FIGS. 38a-38d illustrate another clot retrieval device of the invention;

FIGS. 39a-39d illustrate a further clot retrieval device of the invention;

FIGS. 40a-40e illustrate a method for using a clot retrieval device of the invention;

FIGS. 41a-41d illustrate another method for using a clot retrieval device of the invention;

FIGS. 42a-42g illustrate a further clot retrieval device of the invention;

FIGS. 43a-43h illustrate another clot retrieval device of the invention;

FIGS. 44a-44b illustrate a further clot retrieval device of the invention;

FIG. 45 illustrates another clot retrieval device of the invention;

FIG. 46 illustrates a further clot retrieval device of the invention;

FIG. 47 illustrates another clot retrieval device of the invention;

FIGS. 48a-48f illustrate a further clot retrieval device of the invention;

FIGS. 49a-49f illustrate another clot retrieval device of the invention;

FIGS. 50a-50g illustrate a further clot retrieval device of the invention;

FIGS. 51a-51f illustrate another clot retrieval device of the invention;

FIGS. 52a-52d illustrate a further clot retrieval device of the invention;

FIGS. 53a-53f illustrate a method for using a clot retrieval device of the invention;

FIGS. 54a-54h illustrate another method for using a clot retrieval device of the invention;

FIG. 55 illustrates another clot retrieval device of the invention;

FIG. 56 illustrates a further clot retrieval device of the invention;

FIG. 57 illustrates another clot retrieval device of the invention;

FIG. 58 illustrates a further clot retrieval device of the invention;

FIG. 59 illustrates a further clot retrieval device of the invention;

FIG. 60 illustrates another clot retrieval device of the invention;

FIGS. 61a-61c illustrate a further clot retrieval device of the invention;

FIGS. 62a-62b illustrate another clot retrieval device of the invention;

FIGS. 63a-63b illustrate a further clot retrieval device of the invention;

FIGS. 64a-64b illustrate another clot retrieval device of the invention;

FIGS. 65a-65d illustrate a further clot retrieval device of the invention;

FIGS. 66a-66c illustrate another clot retrieval device of the invention;

FIGS. 67a-67b illustrate a further clot retrieval device of the invention;

FIGS. 68a-68b illustrate another clot retrieval device of the invention;

FIGS. 69a-69b illustrate a further clot retrieval device of the invention; and

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

Specific embodiments of the present invention are now described in detail with reference to the figures, wherein similar reference numbers indicate identical or functionality similar elements. The terms “distal” or “proximal” are used in the following description with respect to a position or direction relative to the treating physician. “Distal” or “distally” are a position distant from or in a direction away from the physician. “Proximal” or “proximally” or “proximate” are a position near or in a direction toward the physician.

The following detailed description is merely exemplary in nature and is not intended to limit the invention or the application and uses of the invention. Although the description of the invention is in the context of treatment of blood arteries such as the carotid and lung arteries, the invention may also be used in any other vessels where it is deemed useful.

As shown generally in FIGS. 1a-1b and 2a-2h, an obstructive clot 2 is occluding a cerebral artery 1 and a guidewire 3 is inserted into the artery 1 using conventionally known techniques. The guidewire 3 is advanced across the clot 2 and then a microcatheter 4 is advanced over the guidewire 3 to a location distal to the clot 2. The mechanical clot retrieval device 10 of the present invention is advanced through the microcatheter 4 and across the clot 2. The retrieval device 10 has an elongate member 11 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 12 configured at the distal end of the elongate member. The ring elements 12 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 12 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 11. When the retrieval device 10 is advanced through the microcatheter 4, the ring elements are in the collapsed configuration substantially parallel to the longitudinal axis of the elongate member 11. Each ring element 12 comprising a plurality of struts 13 is made of self expanding material such as nitinol and is interconnected by ring connecting tethers 14. The microcatheter 4 is retracted after the retrieval device 10 is positioned within or distal of the clot 2 to allow ring elements 12 to deploy and expand. When the ring elements 12 deploy and expand, the struts 13 engage or capture the clot 2 in the ring elements 12 and the retrieval device 10 is retracted proximally out of the artery 1.

FIGS. 3a-3d illustrates one of the preferred embodiments of a mechanical clot retrieval device 20 of the present invention. The retrieval device 20 has an elongate member 21 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 22 configured at the distal end of the elongate member 21. The ring elements 22 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 22 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 21. Each ring element 22 comprising a plurality of struts 23 is made of shape memory material Nitinol and is interconnected by ring connecting tethers 24. Each strut 23 has a crown element 27 with an engagement member 29 and a fixed tab 30. The crown element 27 holds the neighboring crown element 27 in a snap-fit mechanism 28 to restrain the ring elements 22 in the collapsed configuration substantially parallel to the longitudinal axis of the elongate member 21. Two pull tethers 25 which have distal ends that are attached to most proximal ring element 22, and proximal ends that extend exterior of the artery for maneuvering and control by the physician, are present. The snap-fit mechanism 28 restrains the retrieval device 20 in the collapsed configuration when advancing through a microcatheter 4.

FIGS. 4a-4d shows a method of using the retrieval device 20 in accordance with the preferred embodiment as shown in FIGS. 3a-3d. A guidewire (not shown) is inserted in the cerebral artery 1 and is advanced distally across an obstructive clot 2. A microcatheter 4 is advanced over the guidewire to a location proximal to the clot and then the retrieval device 20 of the present invention is advanced through the microcatheter 4 to the clot in the collapsed configuration. The retrieval device 20 has an elongate member 21 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 22 configured at the distal end of an elongate member 21. The ring elements 22 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 22 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 21. When the retrieval device 20 is advanced through the microcatheter 4, the ring elements are in collapsed configuration substantially parallel to the longitudinal axis of the elongate member 21. Each ring element 22 comprises a plurality of struts 23 and is made of shape memory material nitinol and is interconnected by ring connecting tethers 24. The microcatheter 4 is retracted when the retrieval device 20 is positioned within or distal of the clot 2 to allow ring elements 22 to reach the expanded configuration. The pull tethers 25 attached to the retrieval device 20 allow the physician to manually disengage the snap-fit mechanism 28. The ring elements 22 engage or capture the clot 2 from the distal surface of the clot 2 and retract the clot 2 proximally towards the microcatheter 4. The microcatheter 4 is re-advanced to reduce the expanded configuration of the proximal end of the device 20 in order to retrieve it more easily from the artery 1.

FIGS. 5a-5d shows a mechanical clot retrieval device 40 of the present invention which is a slight variant of the embodiment of the retrieval device as shown in FIGS. 3a-3d. The retrieval device 40 has an elongate member 41 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 42 configured at the distal end of the elongate member 41, and a proximal collar 51. The ring elements 42 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 42 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 41. Each ring element 42 comprising a plurality of struts 43 and is made of shape memory material Nitinol and is interconnected by ring connecting tethers 44. Also present are a pair of pull tethers 45, having distal ends which are attached to the most proximal ring element 42 and the proximal ends are attached to the elongate member 41. Each strut 43 has a crown element 47 with an engagement member 49 and an engagement hook 50. Each crown element 47 holds the neighboring crown element 47 in a snap-fit mechanism 48 which restrains the ring elements 42 in the collapsed configuration substantially parallel to the longitudinal axis of the elongate member 41. The snap-fit configuration 48 restrains the retrieval device 40 in the collapsed configuration when advancing through the microcatheter 4.

Another embodiment of the mechanical clot retrieval device of the present invention, which is similar to the one shown in FIGS. 3a-3d, is illustrated in FIGS. 6a-6f The retrieval device 60 has an elongate member 61 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 62 configured at the distal end of the elongate member 61. The ring elements 62 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 62 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 61. Each ring element 62, comprising a plurality of struts 63, is made of shape memory material Nitinol and is interconnected by ring connecting tethers 64. Each strut 63 has a crown element 67 with an engagement member 68. Each engagement member 68 holds the neighboring crown element 67 in a snap-fit mechanism which restrains the ring elements 62 in the collapsed configuration substantially parallel to the longitudinal axis of the elongate member 61. A pair of pull tethers 65 are attached, having distal ends which are attached to each connector (not labeled) of the crown element 67, and proximal ends which extend exterior of the artery for manipulation and control by the physician. The snap-fit mechanism restrains the retrieval device 60 in the collapsed configuration as it is advancing through the microcatheter 4. The pull tethers 65 may be used to manually disengage the snap-fit mechanism and allow the retrieval device 60 reach the expanded configuration.

Another embodiment of the mechanical clot retrieval device of the present invention, which is largely similar to the one shown in FIGS. 3a-3d, is illustrated in FIGS. 7a-7f The retrieval device 80 has an elongate member 81 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 82 configured at the distal end of the elongate member 81. The ring elements 82 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 82 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 81. Each ring element 82, comprising a plurality of struts 83, is made of shape memory material Nitinol and is interconnected by ring connecting tethers 84. Each strut 83 has a crown element 87 with an engagement member 89 and an engagement tab 88. Each crown element 87 holds the neighboring crown element 87 in a snap-fit mechanism which restrains the ring elements 82 in the collapsed configuration substantially parallel to the longitudinal axis of the elongate member 81. A pair of pull tethers 85 is attached, having distal ends which are attached to each engagement tab 88 of the crown element 87, and proximal ends which extend exterior of the artery for manipulation and control by the physician. The snap-fit mechanism restrains the retrieval device 80 in the collapsed configuration as it is advancing through the microcatheter 4. The pull tethers 85 may be used to manually disengage the snap-fit mechanism and allow the retrieval device 80 to reach the expanded configuration.

Another preferred embodiment of the mechanical clot retrieval device 100 of the present invention is illustrated in FIGS. 8a-8d. The retrieval device 100 includes an elongate member 101 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 102 arranged at the distal end of the elongate member 101, a fixed proximal collar 111 and a distal moveable collar 110. The ring elements 102 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 102 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 101. Each ring element 102 comprising a plurality of struts 103 is made of shape memory material nitinol and is interconnected by ring connecting tethers 104. Each strut 103 has a hook lock 107 with first lock 108 and second lock 109. Each hook lock 107 holds the neighboring hook lock 107 in a snap-fit mechanism to restrain the ring elements 102 in the collapsed configuration substantially parallel to the axis of the elongate member 101. There are pair of pull tethers 105 attached, having distal ends which are attached to the distal collar 110, and proximal ends that extend exterior of the artery for maneuvering and control by the physician. The snap-fit mechanism restrains the retrieval device in the collapsed configuration when advancing through the microcatheter 4. The distal collar 110 is pulled proximally by the pull tether 105 to manually disengage and allow ring elements 102 reach an expanded configuration.

FIGS. 9a-9d shows a mechanical clot retrieval device 120 of the present invention, which is a slight variant of the embodiment of the retrieval device 100 as shown in FIGS. 8a-8d; the only difference is use of a balloon 125 in place of the distal moveable collar 110. The retrieval device 120 has an elongate member having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 122 configured at the distal end of the elongate member 121, a proximal collar 126 and a balloon 125. The ring elements 122 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 122 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 121. Each ring element 122 comprises a plurality of struts 123 and is made of shape memory material nitinol and is interconnected by ring connecting tethers 124. Each strut 123 has a hook lock 127 with a first lock 128 and a second lock 109. Each hook lock 127 holds the neighboring hook lock 127 in a snap-fit mechanism to restrain the ring elements 122 in the collapsed configuration. The balloon 125 is in a collapsed state when the device 20 is advanced through the microcatheter 4. The balloon 125 is inflated to disengage and allow ring elements 122 to reach the expanded configuration.

Another embodiment of a mechanical clot retrieval device 140 of the present invention is largely similar to the one shown in FIGS. 8a-8d, and is shown in FIGS. 10a-10d; with the main difference being the use of a ball element 145 in place of the distal movable collar 110. The retrieval device 140 has an elongate member 141 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 142 configured at the distal end of the elongate member 141, a proximal collar 150 attached to a push tube 146, and a ball element 145. The ring elements 142 are self-expandable from a collapsed configuration to an expanded configuration and feature a radial force that biases the ring elements 142 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 141. Each ring element 142, comprising a plurality of struts 143, is made of shape memory material nitinol and is interconnected by ring connecting tethers 144. Each strut 143 has a hook lock 147 with a first lock 148 and a second lock 149. Each hook lock 147 holds the neighboring hook lock 147 in a snap-fit mechanism to restrain the device 140 in the collapsed configuration. The ball element 145 is manually pulled proximally through the device 140 to force apart the ring elements 142 which subsequently form the expanded configuration.

FIGS. 11a-11h shows another preferred embodiment of a mechanical clot retrieval device of the present invention. The retrieval device 160 includes an elongate member 161 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 162 attached to the elongate member 161 by connecting tethers 164 at connection points 165. The ring elements 162 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 162 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 161. Each ring element 162, comprising a plurality of struts 163, is made of shape memory material nitinol. Each strut 163 features a crown element 169, which includes a proximal ring crown 167 and a distal ring crown 166. The connecting tether 164 connects the proximal ring crown 167 with the elongate member 161. The crown element 169 engages with the elongate member 161 in a snap-fit mechanism to restrain the ring elements 162 in the collapsed configuration. The snap-fit mechanism 168 restrains the retrieval device 160 in the collapsed configuration as it advances through a microcatheter 4. The microcatheter 4 is retracted proximally to disengage and allow the ring elements 162 to reach the expanded configuration. The elongate member 161 is manually retracted to disengage the snap-fit mechanism.

Another embodiment of a mechanical clot retrieval device of the present invention is illustrated in FIGS. 12a-12c. A guidewire is inserted inside a cerebral artery 501 using conventional techniques. The guidewire is advanced across an obstructive clot 502 and then an intravascular microcatheter 504 is advanced over the guidewire to a location proximal to the clot 502. The retrieval device 520 has an elongate member having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 522 configured at the distal end 526 of the elongate member 521. The ring elements 522 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 522 towards the expanded configuration. Each ring element 522, comprising a plurality of struts 523, is made of shape memory material nitinol and is interconnected by ring connecting tethers 524. Each strut 523 has a crown element 527 attached to the elongate member 521 by a bonding agent 528 to restrain the ring elements 522 in the collapsed configuration. The radial force is absorbed by the bonding agent 528 to restrain the retrieval device 520 in the collapsed configuration when the device is advancing through the microcatheter 504. The bonding agent 528 is dissolved in vivo to disengage and allow the ring elements 522 to reach the expanded configuration. The device has a pair of pull tethers 525, having distal ends which are attached to most proximal ring element 522 and proximal ends that extend out of the artery for maneuvering and control by the physician.

FIGS. 13a-13f shows a slight variant embodiment of a mechanical clot retrieval device of the present invention, largely similar to the one shown in FIGS. 12a-12c. The difference between the two is the use of a soluble covering 548 in place of the bonding agent 528. The retrieval device 540 has an elongate member, having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 542 configured at the distal end 546 of the elongate member 541. The ring elements 542 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force biasing the ring elements 542 towards the expanded configuration. Each ring element 542, comprising a plurality of struts 543, is made of shape memory material nitinol and is interconnected by ring connecting tethers 544. Each strut 543 has a crown element 547 attached to the elongate member 541 by a re-absorbable covering 548 to restrain the ring elements 542 in the collapsed configuration. The radial force is absorbed by the re-absorbable covering 548 to restrain the retrieval device 540 in the collapsed configuration when it is advancing through the microcatheter (not shown). The re-absorbable covering 548 is dissolved in vivo to disengage and allow the ring elements 542 to reach the expanded configuration. The device features a pair of pull tethers 545, having distal ends which are attached to the most proximal ring element 542 and proximal ends that extend out of the artery for maneuvering and control by the physician.

Another preferred embodiment of a mechanical clot retrieval device of the present invention is shown in FIGS. 14a-14c. The retrieval device 1020 includes an elongate member 1021 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of radial pins 1028, and a plurality of ring elements 1022 configured at the distal end 1026 of the elongate member 1021. The ring elements 1022 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases ring elements 1022 towards the expanded configuration. Each ring element 1022, comprising a plurality of struts, is made of shape memory material nitinol and each strut 1023 contains a crown element 1027 with an eyelet 1024. The distal eyelet 1024 engages with the radial pin 1028 by an engagement element 1029 to fasten the ring elements to the elongate member, whereas proximal eyelets 1024 engage with engagement members 1029 of radial pins 1028 in a snap-fit mechanism to restrain the ring elements 1022 in the collapsed configuration. The ring elements 1022 may be connected to the elongate member 1021 by ring connecting tethers (not shown). The snap-fit mechanism restrains the retrieval device 1020 in the collapsed configuration when advancing through the microcatheter (not shown).

FIGS. 15a-15c and 16a-16d show a method for using a mechanical clot retrieval device 1040 in accordance with the preferred embodiment shown in FIGS. 14a-14c. A guidewire 1003 is inserted in a cerebral artery 1001 and is advanced across an obstructive clot 1002. An intravascular microcatheter 1004 is advanced over the guidewire 1003 to a location proximal to the clot 1002 and then a mechanical clot retrieval device 1004 is advanced through the microcatheter 1004 to the clot 1002 in a collapsed configuration. The retrieval device 1004 includes an elongate member 1041 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of radical pins 1048, and a plurality of ring elements 1042 arranged at the distal end 1046 of the elongate member 1041. The ring elements 1042 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 1042 toward the expanded configuration. Each ring element 1042, comprising a plurality of struts 1043, is made of shape memory material nitinol and each strut features a crown element 1047 with an eyelet 1044. The eyelets 1044 engage with the radial pins 1048 to attach the ring elements to the elongate member. The radial force is absorbed by radial pins to restrain the ring elements 1042 in the collapsed configuration. When microcatheter 1004 is retracted the ring elements 1042 are able to expand and disengage eyelets 1044 from pins 1048 and are thus freed to expand towards the fully expanded configuration. The ring elements 1042 engage or capture the clot and the device can then be retracted proximally and removed from the artery. In one embodiment the ring elements are connected to the elongate member 1041 by tether elements 1045 as shown in FIGS. 16c and 16d.

Another preferred embodiment of a mechanical clot retrieval device of the present invention is illustrated in FIGS. 17a-17d. The retrieval device 1520 includes an elongate member 1521 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery, an outer tube 1530 with a plurality of slots 1532 and a retractable inner core wire 1531 which has a proximal end that extends exterior of the artery, and a plurality of ring elements 1522 configured at the distal end of the elongate member 1521. The ring elements 1522 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 1522 toward the expanded configuration. Each ring element 1522 comprising a plurality of struts 1523 is made of shape memory material nitinol and is interconnected by ring connecting tethers 1525. Each strut 1523 has a crown element 1527 with an eyelet 1524. A tether is advanced out of the slot 1532 to loop 1528 through the eyelet 1524 and advanced back in the slot 1532 to loop 1526 around the core wire 1531 to engage each ring element 1522 to the elongate member 1521 in a tether-loop mechanism. The radial force is absorbed by the tether-loop mechanism to restrain the retrieval device 1520 in the collapsed configuration when advancing through a microcatheter (not shown). The core wire 1531 is retracted proximally thus disengaging and allowing each ring element 1522 reach the expanded configuration.

FIGS. 18a-18c depict a mechanical clot retrieval device 1540 of the present invention which is a variant of the retrieval device 1520 as illustrated in FIGS. 17a-17d. FIG. 18d is a view of a cross-section through line 1553 of FIG. 18b. The retrieval device 1540 includes an elongate member 1541 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery, an outer tube 1550 with a plurality of slots 1552 and a retractable inner core wire 1551 having proximal end 1549 that extends exterior of the artery, and a plurality of ring elements 1542 arranged at the distal end of the elongate member 1541. The ring elements 1542 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 1542 toward the expanded configuration. Each ring element 1542, comprising a plurality of struts 1543, is made of shape memory material nitinol and is interconnected by ring connecting tethers (not shown). Each strut 1543 has a crown element 1547 with an eyelet 1544. The core wire 1551 is advanced out of each slot 1552 to loop 1546 through each eyelet 1544 and advanced back in the slot 1552 to loop inside the outer tube 1550 to engage each ring element 1542 to the elongate member 1541 in a tether-loop mechanism. The radial force is absorbed by the tether-loop mechanism to restrain the retrieval device 1540 in the collapsed configuration when advancing through a microcatheter (not shown). The core wire 1551 is retracted in order to disengage and allow each ring element 1542 reach the expanded configuration.

FIGS. 19a-19d represents a mechanical clot retrieval device of the present invention which is yet another slightly variant embodiment of the retrieval device 1520 as illustrated in FIGS. 17a-17d. The retrieval device 1560 includes an elongate member 1561 having a distal end 1569 that extends interior of the artery, a proximal end that extends exterior of the artery and a tube lumen 1570 with a plurality of slots 1571, and a plurality of ring elements 1562 configured at the distal end of the elongate member 1561. The ring elements 1562 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 1562 toward the expanded configuration. Each ring element 1562, comprising a plurality of struts 1563, is made of shape memory material nitinol and is interconnected by ring connecting tethers 1565. Each strut 1563 has a crown element 1568 with an eyelet 1564. A plurality of tethers 1566 is positioned within the lumen 1570 and is advanced out of each slot 1571 to loop 1567 each eyelet 1564 and is attached at a distal end 1569 of the elongate member 1561 to engage each ring element 1562 to the elongate member 1561 in a tether-loop mechanism. The radial force is absorbed by the tether-loop mechanism to restrain the retrieval device 1560 in the collapsed configuration when advancing through a microcatheter (not shown). The tethers 1566 are broken or cut to disengage and allow each ring element 1562 reach an expanded configuration.

FIGS. 20a-20b shows a mechanical clot retrieval device 1580 of the present invention. The retrieval device 1580 includes an elongate member 1581, a distal end 1569 that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 1582 configured at the distal end of the elongate member 1581 and a proximal collar 1589 attached to an abutment tube 1588. The ring elements 1582 are self-expandable from a collapsed configuration to an expanded configuration and feature a radial force that biases the ring elements 1582 toward the expanded configuration. Each ring element 1582, comprising a plurality of struts 1583, is made of shape memory material nitinol and is attached to the elongate member 1581 by connecting tethers 1585. Each strut 1583 has a crown element 1587. A tether is wrapped around each ring element 1582 and is attached to the elongate member 1581 by a tether loop 1584 to engage each ring element 1582 to the elongate member 1581 in a tether-loop mechanism. The radial force is absorbed by the tether-loop mechanism to restrain the retrieval device 1580 in the collapsed configuration when it is advancing through a microcatheter (not shown). The elongate member 1581 is retracted proximally thus sliding the tether loop 1584 off the ring element 1582 and disengaging and therefore allowing each ring element 1582 reach the expanded configuration.

Another preferred embodiment of a mechanical clot retrieval device of the present invention is illustrated in FIGS. 21a-21f. The retrieval device 2020 includes an elongate member 2021 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 2022 configured at the distal end of the elongate member 2021, and a plurality of beveled 2029 or recessed 2028 collars 2026 configured at distal and proximal ends of each ring element 2022. The ring elements 2022 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 2022 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by collars 2026. Each ring element 2022, comprising a plurality of struts 2023, is made of shape memory material nitinol and is interconnected by tethers (not labeled) and attached to the elongate member 2021 by ring connecting tethers 2025. Each strut 2023 includes a crown element 2027 with a tab 2024 extending axially and radially inward and may be bevel or square shape in shape. The tab 2024 engages with the collar 2026 to restrain the ring element 2022 to the elongate member 2021 in a collar mechanism. The collar mechanism restrains the retrieval device 2020 in the collapsed configuration when advancing through a microcatheter (not shown). The elongate member 2021 is retracted proximally to disengage it and allow each ring element 2022 reach the expanded configuration.

FIGS. 22a-22d shows a method for using the device 2020 in accordance with the preferred embodiment shown in FIGS. 21a-21f A guidewire (not shown) is inserted in a cerebral artery 2000 and is advanced across an obstructive clot 2001. An intravascular microcatheter 2003 is advanced over the guidewire to a location proximal to the clot 2001 and then a mechanical clot retrieval device 2020, sheathed within a bumper tube 2030, is advanced through the microcatheter 2003 to the clot 2001 in a collapsed configuration. The microcatheter 2003 is retracted when the retrieval device 2020 is located distal of the clot. It is unsheathed to allow ring elements 2022 to reach the expanded configuration. The elongate member 2021 of the retrieval device 2020 allows the physician to manually disengage the collar mechanism and the ring connecting tether 2025 attached to the elongate member 2021. The ring elements 2022 engage or capture the clot 2001 from the distal surface of the clot 2001 and retract the clot 2001 proximally to the microcatheter 2003.

FIGS. 23a-23c depicts a mechanism used in a mechanical clot retrieval device 2040 for engaging a tab 2044 with a collar 2046 in a slight variant with the preferred embodiment shown in FIGS. 21a-21f. The retrieval device 2040 includes an elongate member 2041 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a ring element 2042 configured at the distal end of the elongate member 2041 and a proximal collar 2046. The ring element 2042 is self-expandable from a collapsed configuration to an extended configuration and has a radial force that biases the ring element 2042 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the proximal collar 2046. The ring element 2042, comprising plurality of struts 2043, is made of shape memory material nitinol and each strut 2043 has a crown element 2047 with a tab 2044 extending axially and radially inward. The tab 2044 is shaped to engage with the collar 2046, having a recess to restrain the ring element 2042 to the elongate member 2041 in a collar mechanism. The collar mechanism restrains the retrieval device 2040 in the collapsed configuration when advancing through a microcatheter (not shown). The elongate member 2041 is retracted proximally to disengage it and allow each ring element 2042 reach the expanded configuration.

FIGS. 24a-24c shows a mechanical clot retrieval device 2060 of the present invention which is a slightly variant embodiment of the retrieval device 2020 as illustrated in FIGS. 21a-21f The retrieval device 2060 includes an elongate member 2061 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 2062 configured at the distal end of the elongate member 2061, and a plurality of collars 2066 having a plurality of holes 2068 configured proximally of each ring element 2062. The ring members 2062 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 2062 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by collars 2066. Each ring element 2062, comprising a plurality of struts 2063, is made of shape memory material nitinol and is interconnected by ring connecting tethers 2069. Each strut 2063 has a crown element 2067 with a pin 2064 extending axially and radially inward. The pin 2064 engages with the hole 2068 to restrain the ring elements 2062 to the elongate member 2061 in a collar mechanism. The device includes a pair of cables 2065 having distal ends which are attached to the most proximal ring element 2062 and proximal ends that extend exterior of the artery for manipulation and control by the physician. The collar mechanism restrains the retrieval device 2060 in the collapsed configuration when it is advancing through a microcatheter 2003. The cables 2065 are manually pulled proximally to disengage the collar mechanism and allow each ring element 2062 reach the expanded configuration.

FIGS. 25a-25k represents a mechanical clot retrieval device 2080 of the present invention which is another slightly variant embodiment of the retrieval device 2020 as illustrated in FIGS. 21a-21f. The retrieval device 2080 includes elongate member 2081 a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 2082 configured at the distal end of the elongate member 2081, and a plurality of shaped engagement collars 2085 having a plurality of dove tail grooves 2088 configured proximally of each ring element 2082. The ring elements 2082 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 2082 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by collars 2085. Each ring element 2082, comprising a plurality of struts 2083, is made of shape memory material nitinol and is attached to the elongate member 2081 by tethers 2089. Each strut 2083 has a crown element 2087 with a shaped tab 2084 extending axially and radially inward. The shaped tab 2084 engages with the shaped engagement collar 2085 to restrain the ring element 2082 to the elongate member 2081 in a collar mechanism. The collar mechanism restrains the retrieval device 2080 in the collapsed configuration when it is advancing through a microcatheter (not shown). The elongate member 2081 is manually retracted proximally to disengage it and allow each ring element 2082 reach the expanded configuration.

FIGS. 26a-26c represents a slightly variant embodiment of the retrieval device 2080 as represented in FIGS. 25a-25k, having additional ring connecting tethers 2101 interconnecting each ring element 2082.

Another preferred embodiment of a mechanical clot retrieval device 2520 of the present invention is illustrated in FIGS. 27a-27b. The retrieval device 2520 includes an elongate member 2521 having a distal end that extends interior of the artery, a proximal end that ends interior of the artery and an inner lumen 2529 with a plurality of openings (not labeled), and a plurality of ring elements 2522 configured at the distal end of the elongate member 2521. The ring elements 2522 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases ring elements 2522 toward the expanded configuration. Each ring element 2522, comprising a plurality of struts 2523, is interconnected by ring connecting tethers 2525. Each strut 2523 has a crown element 2527 and an engagement tab 2524. A plurality of tether loops 2526 having proximal ends that extend exterior of the lumen 2529 is advanced out of each opening (not opening) to circle the engagement tab 2524 and engage each ring element 2522 to the elongate member 2521 in an eyelet mechanism. The radial force is absorbed by the eyelet mechanism to restrain the retrieval device 2520 in the collapsed configuration when it is advancing through a microcatheter (not shown). The tethers are manually pulled proximally to disengage them and allow each ring element 2522 to reach the expanded configuration.

FIGS. 28a-28b represents a mechanical clot retrieval device 2540 of the present invention which is a slightly variant embodiment of the retrieval device 2520 as illustrated in FIGS. 27a-27b. The retrieval device 2540 includes an elongate member 2541 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of raised tabs 2548, and a plurality of ring elements 2542 configured at the distal end of the elongate member 2541. The ring elements 2542 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 2542 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by raised tabs 2548. Each ring element 2542, comprising a plurality of struts 2543, is interconnected by ring connecting tethers 2545. Each strut 2543 has a crown element and an engagement tab 2544. The engagement tab 2544 engages with the raised tab 2548 to restrain the ring element 2542 to the elongate member 2541 in an eyelet mechanism. The eyelet mechanism restrains the retrieval device 2540 in the collapsed configuration when it is advancing through a microcatheter (not shown). The elongate member 2541 is manually retracted proximally to disengage it and allow each ring element 2542 to reach the expanded configuration.

FIGS. 29a-29h shows a method for using a mechanical clot retrieval device 2560 in accordance with the preferred embodiment shown in FIGS. 27a-27b and 28a-28b. A guidewire 2502 is inserted in a cerebral artery 2500 and is advanced through an obstructive clot 2501. An intravascular microcatheter 2503 is advanced over the guidewire 2502 to a location distal to the clot 2501 and then the retrieval device 2560 is advanced through the microcatheter 2503 to the clot 2501 in a collapsed configuration. The microcatheter 2503 is retracted when the retrieval device 2560 is positioned distal of the clot 2501 to allow a plurality of ring elements 2562 to reach an expanded configuration. The ring elements 2562, comprising a plurality of struts 2563, are interconnected by ring connecting tethers 2565. A tether 2564 is attached at a distal end of the retrieval device 2560 and its proximal end extends out of the artery. The elongate member 2561 and tether 2564 allows the physician to manually disengage eyelet mechanism. The ring elements 2562 engage or capture the clot 2501 from the distal end of the clot 2501 and retract the clot 2501 proximally to the microcatheter 2504.

Another embodiment of a mechanical clot retrieval device 3020 of the present invention is illustrated in FIGS. 30a-30e. The retrieval device 3020 includes an elongate member 3021 designed to have a distal end that extends interior of the artery, a proximal end that extends exterior of the artery, a plurality of engagement diameters 3028 and a plurality of disengagement diameters 3029, a plurality of ring elements 3022 configured at the distal end of the elongate member 3021, and a proximal abutment tube 3031. The ring elements 3022 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3022 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the engagement diameters. Each ring element 3022 comprising a plurality of struts 3023 is interconnected by ring connecting tethers 3025. Each strut 3023 has a crown element 3027 with a C-shaped engagement tab 3030 extending radially inward. The C-shaped engagement tab 3030 engages with the engagement diameter 3028 to restrain the ring element 3022 to the elongate member 3021 in the collapsed configuration when it is advanced through a microcatheter (not shown). The device features a pair of control tethers 3026 having distal ends which are attached to the crown element 3027 of the most proximal ring element 3022. The axial movement of the elongate member 3021 disengages each ring element 3022 at the disengagement diameter 3029 and allows each ring element 3022 to reach the expanded configuration.

FIGS. 31a-31e shows a mechanical clot retrieval device 3040 of the present invention which is a slightly variant embodiment of the retrieval device 3020 as illustrated in FIGS. 30a-30e. The retrieval device 3040 includes an elongate member 3041 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and an inner wire 3051, a plurality of ring elements 3042 arranged at a distal end of the elongate member 3041, and a proximal abutment tube 3052. The ring elements 3042 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3042 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member having inner wire 3051. Each ring element 3042 comprising a plurality of struts 3042 is interconnected by ring connecting tethers 3045. Each strut 3043 has a crown element 3047 with a C-shaped engagement tab 3050 extending radially inward. The C-shaped engagement tab 3050 engages with the elongate member 3041. The inner wire 3051 restrains the retrieval device 3040 in the collapsed configuration when it is advanced through a microcatheter (not shown). The device features a pair of control tethers 3046 having distal ends which are attached to the crown element 3047 of the most proximal ring element 3042 and proximal ends which are attached to the abutment tube 3052. The withdrawal of the inner wire 3051 disengages it and allows each ring element 3042 reach the expanded configuration.

FIGS. 32a-32d illustrates the mechanical clot retrieval device 3060 of the present invention. The retrieval device 3060 includes an elongate member 3061 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and an inner lumen 3071 with a plurality of slots 3070, a plurality of ring elements 3062 configured at the distal end of the elongate member 3061, and a proximal collar 3066. The ring elements 3062 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3062 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by slots 3070. Each ring element 3062, comprising a plurality of struts 3063, is interconnected by ring connecting tethers 3065. Each strut 3063 has a crown element 3067 with a stepped engagement tab 3064 extending longitudinally and radially. The engagement tab 3064 engages with the slot 3070 to restrain the ring elements 3062 to the elongate member 3061 and to restrain the retrieval device 3060 in the collapsed configuration when it is advanced through a microcatheter (not shown). A pair of control tethers 3068 is attached from the crown element 3067 of the most proximal ring element 3062, to the proximal collar 3066. The proximal collar 3066 is manually pulled proximally to disengage it and allow the ring elements 3062 to reach an expanded configuration.

FIGS. 33a-33g represents another embodiment of a mechanical clot retrieval device of the present invention. The retrieval device 3080 includes an elongate member 3081 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of monofilaments 3088, a plurality of ring elements 3082 configured at the distal end of the elongate member 3081, and a proximal collar 3086. The ring elements 3082 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force biasing the ring elements 3082 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the monofilaments. Each ring element 3082 comprising a plurality of struts 3083 is interconnected by ring connecting tethers 3085. Each strut 3082 has a crown element 3087 with a C-shaped engagement tab 3084. The C-shaped engagement tab 3084 engages with the monofilament 3088 to restrain the ring element 3082 to the elongate member 3081 in a snap-fit mechanism. The snap-fit mechanism restrains the retrieval device 3080 in the collapsed configuration when it is advancing through a microcatheter (not shown). The device contains a pair of control tethers 3089 having distal ends which are attached to the crown element 3087 of the most proximal ring element 3082 and proximal ends which are attached to the collar 3086. The elongate member 3081 is manually retracted to disengage it and allow each ring element 3082 reach the expanded configuration.

Another embodiment of a mechanical clot retrieval device of the present invention is shown in FIGS. 34a-34j. The retrieval device 3100 includes an elongate member 3101 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of inactivated cuffs 3108a configured at the distal end of the elongate member 3101, a plurality of ring elements 3102 configured over the cuff 3108a, and a tube 3106. Each cuff 3108a is made of electro-active polymer which swells to an activated state 3108b when current is applied. The ring elements 3102 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force biasing the ring elements 3102 toward the expanded configuration. Each ring element 3102 comprising a plurality of struts 3103 is interconnected by ring connecting tethers 3105. Each strut has a crown element 3107. A pair of control tethers 3104 are attached to the crown element 3107 of the most proximal ring element 3102, having proximal ends that extend out of the artery. A ring restraining tether 3109 is wrapped around each ring element 3102 restraining it to the elongate member 3101 in the collapsed configuration when it is advanced through a microcatheter (not shown). In the collapsed configuration, the radial force is absorbed by the ring restraining tethers 3109. The current is applied through the restraining tether 3109 to allow each cuff 3108a to reach activated state 3108b and then they are manually pulled proximally to disengage them and allow each ring element 3102 reach the expanded configuration.

FIGS. 35a-35b represents another embodiment of a mechanical clot retrieval device of the present invention. The retrieval device 3120 includes an elongate member 3121 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3122 configured at the distal end of the elongate member 3121, a proximal collar 3129, and a bumper tube 3126. The ring elements 3122 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force biasing the ring elements 3122 toward the expanded configuration. Each ring element 3122, comprising a plurality of struts 3123, is interconnected by ring connecting tethers 3125. Each strut 3123 has a crown element 3127 with an eyelet 3128. A tether loop 3130 engages each ring element 3122 to the elongate member 3121 to restrain the retrieval device 3120 in the collapsed configuration when it is advancing through a microcatheter 3003. In the collapsed configuration, the radial force is absorbed by tether loops 3130. The device contains a pair of control tethers 3124, having distal ends which are attached to the crown element 3127 of the most proximal ring element 3122 and proximal ends which extend out of the artery. The elongate member 3121 is manually retracted proximally to disengage it and allow each ring element 3122 reach the expanded configuration.

Another embodiment of a mechanical clot retrieval device of the present invention is shown in FIGS. 36a-36d. The retrieval device 3140 includes an elongate member 3141 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3142 arranged at the distal end of the elongate member 3141, a bumper tube 3146 and a proximal collar 3149. The ring elements 3142 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force biasing ring elements toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 3141. Each ring element 3142 comprising a plurality of struts 3143 is interconnected by ring connecting tethers 3145. Each strut 3143 has a crown element 3147 with an engagement tab 3148 having an eyelet 3144. The elongate member 3141 passes through each eyelet 3144 engaging each ring element 3142 to the elongate member 3141 to restrain the retrieval device 3140 in the collapsed configuration when it is advancing through a microcatheter 3003. The elongate member 3141 is manually retracted proximally to disengage it and allow each ring element 3142 reach the expanded configuration.

FIGS. 37a-37i represents a mechanical clot retrieval device of the present invention which is a slightly variant embodiment of the retrieval device 3140 as shown in FIGS. 36a-36d. The retrieval device 3160 includes an elongate member 3161 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3162 configured at the distal end of the elongate member 3161, a bumper tube (not labeled) and a proximal collar (not labeled). The ring elements 3162 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force biasing the ring elements 3162 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 3161. Each ring element 3162 comprising a plurality of struts 3163 is interconnected by ring connecting tethers (not labeled). Each strut has a crown element 3167 with an engagement tab 3166 and an eyelet 3168. The elongate member 3161 passes through each eyelet 3168 engaging each ring element 3162 to the elongate member 3161 to restrain the retrieval device 3160 in the collapsed configuration when it is advancing through a microcatheter 3003. The elongate member 3161 is manually retracted proximally to disengage and allow each ring element 3162 reach the expanded configuration.

Another embodiment of a mechanical clot retrieval device of the present invention is illustrated in FIGS. 38a-38d. The retrieval device 3200 has an elongate member 3201 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of restraining loops 3206 configured at the distal end of the elongate member 3201, and a plurality of ring elements 3202 arranged at the distal end of the elongate member 3201. The ring elements 3202 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3202 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the restraining loops 3206. Each ring element 3202 comprising a plurality of struts 3203 is connected to the loop 3206 by connecting tethers 3205. Each strut 3203 is having a crown element 3207. The device features a pair of control tethers 3204, having distal ends which are attached to the crown element 3207 of the most proximal ring element 3202, and proximal ends that extend out of the artery. The loops 3206 engage the ring elements 3202 to the elongate member 3201 in an offset loop mechanism. The offset loop mechanism restrains the retrieval device 3200 in the collapsed configuration when it is advanced through a microcatheter (not shown). The elongate member 3201 is manually retracted proximally to disengage it and allow each ring element 3202 to reach the expanded configuration.

Another embodiment of a mechanical clot retrieval device 3300 of the present invention is illustrated in FIGS. 39a-39d. The retrieval device 3300 has an elongate member 3301 having a distal end that extends interior of the artery and a proximal end that extend exterior of the artery, a plurality of ring elements 3302 arranged at the distal end of the elongate member 3301, a bumper tube 3306, and a proximal collar 3308. The ring elements 3302 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 3301. Each ring element 3302, comprising a plurality of struts 3303, is interconnected by ring connecting tethers 3305. Each strut 3303 has a crown element 3307. The device has comprises a pair of control tethers 3304, having distal ends which are attached to the crown element 3307 of the most proximal ring element 3302 and proximal ends that are attached to the bumper tube 3306. The crown element 3307 of each strut 3303 is confined around the elongate member 3301 to restrain the ring element 3302 to the elongate member 3301 when it is advanced through a microcatheter 3309. The elongate member 3301 is retracted proximally to disengage it and allow each ring element 3302 to reach the expanded configuration.

FIGS. 40a-40e and 41a-41d shows a method of advancing a mechanical clot retrieval device 3405 in accordance with a preferred embodiment of the present invention in a tortuous vessel 3400. A guidewire 3402 is inserted in the vessel 3400 and is advanced through an obstructive clot 3401. An intravascular microcatheter 3403 is advanced over the guidewire to a location distal to the clot 3401 and then the retrieval device 3405 is advanced through the microcatheter 3403 to the clot 3401 in a collapsed configuration. The microcatheter 3403 is retracted to allow the plurality of ring elements (not labeled) to reach an expanded configuration. The ring elements (not labeled) contain a plurality of struts (not labeled). Each ring element is connected to the next ring element (not labeled) by a ring connecting tether 3406. A control tether 3407 is attached to the strut (not labeled) of the proximal ring element having a proximal end that extends out of the patient to allow physician to manually maneuver the retrieval device 3405. The retrieval device 3405 engages or captures the clot 3401 from the distal end of the clot 3401 and retracts the clot 3401 proximally into the microcatheter 3403.

FIGS. 42a-42d, 43a-43h and 44a-44b illustrates the mechanical clot retrieval device 3420 of the present invention. The retrieval device 3420 includes an elongate member 3421 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 3422 configured at the distal end of the elongate member 3421. The ring elements 3422 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3422 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3420 is delivered inside the artery. Each ring element 3422, comprising a plurality of struts 3423, is interconnected by ring connecting tethers 3425. Each strut 3423 has a crown element 3427 with or without a shaped tab 3428 or an eyelet 3426. The crown element 3427 is connected to neighboring crown element 3427 by the tether 3425 which may be looped around tab 3428 or passed through eyelet 3426.

The crown element 3427 which is without the shaped tab 3428 or the eyelet 3426 may be connected to neighboring crown element 3427 by an adhesive bond 3429. Crown-to-crown 3427 connection restrains the retrieval device 3420 in the collapsed configuration when advanced through the intravascular microcatheter (not shown). The device features a pair of removal tethers 3424, having distal ends which are attached to the crown element 3427 of the most proximal ring element 3422, and proximal ends that extend out of the artery. The microcatheter is retracted proximally and tether 3424 is manually pulled proximally to disengage it and allow each ring element 3422 reach the expanded configuration.

Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 45. The retrieval device 3440 has an elongate member 3441 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3442 having a first diameter and a second diameter, and a control strut 3444 having distal end attached to proximal ring element 3442 and proximal end attached to the elongate member 3441 by adhesive bonds 3446. The ring elements 3442 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3442 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3440 is delivered inside the artery. Each ring element 3442, comprising a plurality of struts 3443, is connected by ring connecting tethers 3445. Each strut 3443 has a crown element 3447. The crown element 3447 is connected to neighboring crown element 3447 by the tether 3445. Crown-to-crown connection restrains the retrieval device 3440 in the collapsed configuration when it is advanced through the microcatheter (not shown). The microcatheter is retracted proximally and each ring element 3442 disengages to create a zigzag stent surface for improved clot engagement.

FIG. 46 represents a mechanical clot retrieval device 3460 of the present invention which is a slightly variant embodiment of the retrieval device as illustrated by FIG. 46. The retrieval device 3460 has an elongate member 3461 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3462 attached at the distal end of the elongate member and a control strut 3464 having a distal end attached to the most proximal ring element 3462 and a proximal end attached to the elongate member 3461 by adhesive bonds 3466. The ring elements 3462 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3460 is delivered inside the artery. Each ring element 3462, comprising a plurality of struts 3463, is connected by ring connecting tethers 3465. Each strut 3463 has a crown element 3467. The crown element 3467 is connected to the neighboring crown 3467 by a connecting strut 3468 to restrain the retrieval device 3460 in the collapsed configuration when it is advanced through the microcatheter (not shown). The microcatheter is retracted proximally and each ring element 3462 disengages to create a zigzag stent surface for improved clot engagement.

FIG. 47 represents a mechanical clot retrieval device 3480 of the present invention which is another variant embodiment of the retrieval device as illustrated in FIG. 46. The retrieval device 3480 has an elongate member 3481 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3482 and a control strut 3484 having a distal end attached to the proximal ring element 3482 and a proximal end attached to the elongate member 3481. The ring elements 3482 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3482 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter, through which the retrieval device 3480 is delivered inside the artery. Each ring element 3482, comprising a plurality of struts 3483, is connected by ring connecting tethers 3485. Each strut 3483 has a crown element 3487. The crown element 3487 is connected to the neighboring crown 3487 by the tether 3485 and adhesive bond 3486. Crown-to-crown connection restrains the retrieval device 3480 in the collapsed configuration when it is advanced through a microcatheter (not shown). The microcatheter is retracted and each ring element 3482 disengages to create a zigzag stent surface for improved clot engagement.

Another preferred embodiment of a mechanical clot retrieval device of the present invention is illustrated in FIGS. 48a-48f. The retrieval device 3500 includes an elongate member 3501 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3502, and a pair of removal tethers 3504 having distal ends attached to the proximal ring element 3502 and proximal ends attached to the elongate member 3501. The ring elements 3502 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3502 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3403, through which the retrieval device 3500 is delivered inside the artery. Each ring element 3502, comprising a plurality of struts 3503, is interconnected by ring connecting tethers 3505. Each strut 3503 has a crown element 3507. The distally facing crown element 3507 is connected to the neighboring proximally facing crown 3507 by the tether 3505. Crown-to-crown connection restrains the retrieval device 3500 in the collapsed configuration when advanced through the microcatheter 3403. The microcatheter 3403 is advanced inside a torturous artery 3400 and is positioned distal of an obstructive clot 3401. The microcatheter 3403 is retracted to allow each ring element 3502 reach the expanded configuration and engage or capture the clot 3401 from the distal end of the clot 3401 and the device is then retracted proximally into the microcatheter 3403.

FIGS. 49a-49f represents a mechanical clot retrieval device of the present invention which is a slightly variant embodiment of the retrieval device 3500 as illustrated in FIGS. 48a-48f The retrieval device has an elongate member 3521 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3522, and a control strut 3524 having a distal end attached to the proximal ring element 3522 and a proximal end attached to the elongate member 3521. The ring elements 3522 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3522 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3403 through which the retrieval device 3520 is delivered inside the artery. Each ring element 3522, comprising a plurality of struts 3523, is connected by ring connecting tethers 3525. Each strut 3523 has a crown element 3527. The distally facing crown element 3527 is connected to neighboring proximally facing crown 3527 by the tether 3525. Crown-to-crown 3527 connection restrains the retrieval device 3520 in the collapsed configuration when advanced through the microcatheter 3403. The microcatheter 3403 is advanced over a guidewire (not shown) inside a torturous artery 3400 and positioned distal of an obstructive clot 3401. The microcatheter 3403 is retracted proximally to allow each ring element 3522 reach the expanded configuration and engage or capture the clot 3401 from the distal end of the clot 3401 and the device is then retracted proximally into the microcatheter 3403.

FIGS. 50a-50g shows a mechanical clot retrieval device 3540a of the present invention which is another slightly variant embodiment of the retrieval device 3500 as illustrated in FIGS. 48a-48f. The retrieval device 3540a includes an elongate member 3541 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3542 configured at the distal end of the elongate member 3541 and a plurality of connecting tethers 3545 having distal ends attached to the ring element 3542 and proximal ends attached to the elongate member 3541. The ring elements 3542 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3542 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3403 through which the retrieval device 3540a is delivered inside the artery. Each ring element 3542 comprising a plurality of struts 3543. Each strut 3543 has a crown element 3547. The distally facing crown element 3547 is connected to neighboring proximally facing crown 3547 by the tether 3545. Crown-crown 3547 connection restrains the retrieval device 3540a in the collapse configuration when advanced through a microcatheter 3403. The microcatheter 3403 is advanced over a guidewire (not shown) inside a tortuous artery 3400 and positioned distal of an obstructive clot 3401. The microcatheter 3403 is retracted to allow each ring element 3542 to reach the expanded configuration and engage or capture the clot 3401 from the distal base of the clot 3401 and the device is then retracted proximally to the microcatheter 3403.

Another embodiment of a mechanical clot retrieval device 3560 of the present invention is illustrated in FIGS. 51a-51f The retrieval device 3560 includes an elongate member 3561 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3562 configured at the distal end of the elongate member 3561, a plurality of connecting tethers 3565 having distal ends attached to the ring element 3562 and proximal ends attached to the elongate member 3561, and a pair of removal tethers 3564 having distal ends attached to the most proximal ring element 3562 and proximal ends that extend out of the artery. The ring elements 3562 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3562 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3403 through which the retrieval device 3560 is delivered inside the artery. Each ring element 3562 comprises a plurality of struts 3563. Each strut 3563 has a crown element 3567. The connecting tether 3565 engages each ring element 3562 to the elongate member 3562 to restrain the retrieval device 3560 in the collapsed configuration when it is advanced through a microcatheter 3403. The microcatheter 3403 is advanced over a guidewire (not shown) inside a tortuous artery 3400 and positioned distal of an obstructive clot 3401. The microcatheter 3403 is retracted to allow each ring element 3562 reach the expanded configuration and engage or capture the clot 3401 from the distal base of the clot 3401 and retracted proximally to the microcatheter 3403.

FIGS. 52a-52d represents a mechanical clot retrieval device 3580 of the present invention which is a slightly variant embodiment of the retrieval device 3560 as illustrated in FIGS. 51a-51f. The retrieval device 3580 has an elongate member 3581 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3582 configured at the distal end of the elongate member 3581 and a plurality of connecting tethers 3585 having distal ends attached to the ring member 3582 and proximal ends attached to the elongate member 3581. The ring elements 3582 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3582 towards the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3403 through which the retrieval device 3580 is delivered inside the artery. Each ring element 3582 comprises a plurality of struts 3583. Each strut 3583 has a crown element 3587. Each ring element 3582 is wrapped around the elongate member 3581 to restrain the retrieval device 3580 in the collapsed configuration when it is advanced through a microcatheter 3403. The microcatheter 3403 is advanced over a guidewire (not shown) inside a tortuous artery and positioned distal of an obstructive clot 3401. The microcatheter 3403 is retracted to allow each ring element 3582 to reach the expanded configuration and engage or capture the clot 3401 from the distal base of the clot (not shown) and then the device is retracted proximally into the microcatheter 3403.

FIGS. 53a-53f shows a method of using a mechanical clot retrieval device 3600 of the present invention in the embodiment as illustrated in FIGS. 52a-52d. A guide catheter 3601 is inserted inside the artery and a guidewire (not shown) is advanced within the catheter 3601 bypassing an occlusive clot (not shown). A microcatheter 3602 is advanced over the guidewire (not shown) to a location distal to the clot (not shown) and then the retrieval device 3600 is advanced through the microcatheter 3602 to the clot (not shown) in a collapsed configuration. The microcatheter 3602 is retracted to allow ring elements 3604 to reach an expanded configuration. The ring elements 3604 are self-expandable from the collapsed configuration to the expanded configuration and each ring element comprises plurality of struts 3605. Each strut 3605 has a crown element 3607. The ring elements 3604 are attached to the elongate member 3603 by connecting tethers 3606 and are wrapped around the elongate member 3603 to restrain the retrieval device 3600 in the collapsed configuration when it is advanced through the microcatheter 3602. The ring elements 3604, when expanded, engage or capture the clot (not shown) from the distal base of the clot (not shown) and retract the clot (not shown) proximally to the microcatheter 3602. The retrieval device 3600 returns to the collapsed configuration while retracting into the guide catheter 3601 and is easily removed from the artery.

FIGS. 54a-54h shows another method of using a mechanical clot retrieval device 3620 of the present invention in accordance with the embodiment as illustrated in FIGS. 52a-52d. A guidewire 3404 is inserted in a tortuous artery 3400 and advanced through an obstructive clot 3401. A microcatheter 3403 is advanced over the guidewire 3404 to a location distal to the clot 3401 and then the retrieval device 3620 is advanced through the microcatheter 3403 to the clot 3401 in a collapsed configuration. The microcatheter 3403 is retracted when the retrieval device 3620 is positioned distal of the clot 3401 to allow ring elements 3622 to reach an expanded configuration. The ring elements 3622 are self-expandable from the collapsed configuration to the expanded configuration and are wrapped around the elongate member 3621 to restrain the retrieval device 3620 in the collapsed configuration when advanced through the microcatheter 3403. A removal tether 3624 is attached to the retrieval device 3620. The ring elements 3622, when expanded using an activation element 3626, engage or capture the clot 3401 from the distal base of the clot 3401 and retract the clot 3401 proximally to the microcatheter 3603. The retrieval device 3620 returns to the collapsed configuration while retracting into a guide catheter 3627 and is easily removed from the artery 3400.

Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 55. The retrieval device 3700 has an elongate member 3701 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3702a having a larger diameter and a plurality of ring elements having a smaller diameter 3702b, and a control strut 3704 having distal end attached to proximal ring element 3702a and proximal end attached to the elongate member 3701 by adhesive bonds 3706. The ring elements 3702a and 3702b are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3702a and 3702b toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3700 is delivered inside the artery. Each ring element 3702a, and 3702b comprises a plurality of struts 3703. Each strut 3703 has a crown element 3707. The crown element 3707 is connected to neighboring crown element 3707 by the ring to ring connection 3705. The ring to ring connection 3705 restrains the retrieval device 3700 in the collapsed configuration when it is advanced through the microcatheter (not shown). The microcatheter is retracted proximally and each ring element 3702 disengages to form the expanded configuration.

Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 56. The retrieval device 3720 has an elongate member 3721 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3722, and a removal tether 3724 having distal end attached to proximal ring element 3722 and proximal end attached to the elongate member 3721. The ring elements 3722 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3722 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3720 is delivered inside the artery. Each ring element 3722 comprises a plurality of struts 3723. The outer mesh 3725 restrains the retrieval device 3720 and limits it to a certain diameter in the expanded configuration. The microcatheter is retracted proximally and each ring element 3722 disengages to form the maximum allowable diameter within the outer mesh.

Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 57. The retrieval device 3740 has an elongate member 3741 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3742, and a removal tether 3744 having distal end attached to proximal ring element 3742 and proximal end attached to the elongate member 3741. The ring elements 3742 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3742 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3740 is delivered inside the artery. Each ring element 3742 comprises a plurality of struts 3743. The tether net cover 3745 restrains the retrieval device 3740 and limits it to a certain diameter in the expanded configuration. The microcatheter is retracted proximally and each ring element 3742 disengages to form the maximum diameter allowed by the tether net cover.

Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 58. The retrieval device 3760 has an elongate member 3761 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3762, and a control strut 3764 having distal end attached to proximal ring element 3762 and proximal end attached to the elongate member 3761 by adhesive bonds 3766. The ring elements 3762 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3762 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3760 is delivered inside the artery. Each ring element 3762 comprises a plurality of struts 3763. Each strut 3763 has a crown element 3767. The crown element 3767 is connected to neighboring crown element 3767 by the ring to ring connection 3765. The ring to ring connection 3765 restrains the retrieval device 3760 in the collapsed configuration when it is advanced through the microcatheter (not shown). The microcatheter is retracted proximally and each ring element 3762 disengages to form the expanded configuration.

Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 59. The retrieval device 3780 has an elongate member 3781 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3782, and a removal tether 3784 having distal end attached to proximal ring element 3782 and proximal end attached to the elongate member 3781. The ring elements 3782 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3782 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3780 is delivered inside the artery. Each ring element 3782 comprises a plurality of struts 3783. The tether net cover 3785 restrains the retrieval device 3780 and limits it to a certain diameter in the expanded configuration. The device also comprises a tapered ring element at the distal end of the tether net cover 3785. The microcatheter is retracted proximally and each ring element 3782 disengages to form the maximum diameter allowed by the tether net cover 3785.

Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 60. The retrieval device 3800 has an elongate member 3801 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3802, and a control strut 3804 having distal end attached to proximal ring element 3802 and proximal end attached to the elongate member 3801 by adhesive bonds 3806. The ring elements 3802 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3802 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3780 is delivered inside the artery. Each ring element 3802 comprises a plurality of struts 3803. Each strut 3803 has a crown element 3807. The crown element 3807 is connected to neighboring crown element 3807 by the ring to ring connection 3805. The ring to ring connection 3805 restrains the retrieval device 3800 in the collapsed configuration when it is advanced through the microcatheter (not shown). The ring elements are wrapped in an outer mesh/net cover 3808 which limits the diameter of the ring elements in the expanded configuration. The microcatheter is retracted proximally and each ring element 3802 disengages to form the expanded configuration with the maximum diameter allowed by the outer mesh/net cover 3808.

Another preferred embodiment of a mechanical clot retrieval device 3820 of the present invention is illustrated in FIGS. 61a-61c. The retrieval device 3820 is advanced through a microcatheter 3821 inside the patient artery and includes an activation tether 3824, having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a distal collar 3827, and a plurality of ring elements 3822 configured to the distal end of the activation tether 3824. The ring elements 3822 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3822 in the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3821 through which the retrieval device 3820 is delivered inside the artery. Each ring element 3822, comprising a plurality of struts 3823, is interconnected by bridges 3825. The microcatheter 3821 is retracted and the activation tether 3824 is manually pulled proximally to compress the device and allow ring elements 3822 to reach the expanded configuration.

FIGS. 62a-62b shows a mechanical clot retrieval device 3840 of the present invention which is a slightly variant embodiment of the retrieval device as illustrated in FIGS. 61a-61c. The retrieval device 3840 is advanced through a microcatheter 3841 inside the artery and has an activation tether 3844, having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a distal collar 3847, and a ring element 3846 configured at the distal end of the activation tether 3844. The ring element 3846 is self-expandable from a collapsed configuration to an expanded configuration and comprises a radial force that biases the ring element 3846 to the expanded configuration. The ring element comprises a plurality of struts 3843. The microcatheter 3841 is retracted and the activation tether 3844 is manually pulled proximally to compress the device proximally and allow ring elements 3842 to reach the expanded configuration.

FIGS. 63a-63b shows a mechanical clot retrieval device 3860 of the present invention which is a slightly variant embodiment of the retrieval device 3840 as illustrated in FIGS. 62a-62b. The retrieval device 3862 is advanced through a microcatheter 3861 inside the artery and has an activation tether 3864 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a distal collar 3867, a ring element 3866 configured at the distal end of the activation tether 3864, and a pair of removal tethers 3862 attached to the ring element 3866 having proximal ends that extend out of the artery. The ring element 3866 is self-expandable from a collapsed configuration to an expanded configuration and comprises a radial force that biases the ring element 3866 to the expanded configuration. In the collapsed configuration, the radial force is absorbed by the microcatheter. The microcatheter 3861 is retracted and the activation tether 3864 is manually pulled proximally to compress the device proximally and allow ring element 3866 to reach the expanded configuration.

FIGS. 64a-64b shows a mechanical clot retrieval device 3880 of the present invention which is a slightly variant embodiment of the retrieval device 3860 as illustrated in FIGS. 63a-63b. The retrieval device 3882 is advanced through a microcatheter 3881 inside the patient artery and has an activation tether 3884 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a couple of collars 3887, a couple of ring elements 3886 configured at the distal end of the activation tether 3884, and a pair of removal tethers 3882 having distal ends attached to the ring element 3886 and having proximal attached to the collar 3887. The ring element 3886 is self-expandable from a collapsed configuration to an expanded configuration and has a radial force that biases the ring element 3886 to the expanded configuration. In the collapsed configuration, the radial force is absorbed by the microcatheter 3881. Each ring element 3886 comprises a plurality of struts 3883. The microcatheter 3881 is retracted and the activation tether 3884 is manually pulled proximally to compress the device and to allow ring element 3886 reach the expanded configuration.

FIGS. 65a-65d illustrates another preferred embodiment of a mechanical clot retrieval device 3900a of the present invention. The retrieval device 3900a is advanced through a microcatheter 3901 inside the patient artery and has a pair of activation tethers 3904 having distal ends that extend interior of the artery and proximal ends that extend exterior of the artery, a distal collar 3907, and a plurality of ring elements 3902 configured to the distal end of the activation tether 3904. The ring elements 3902 are self-expandable from a collapsed configuration 3900a to an expanded configuration 3900b and have a radial force that biases the ring elements 3902 to the expanded configuration 3900b. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3901 through which the retrieval device 3900a is delivered inside the artery. Each ring element 3902, comprising a plurality of struts 3903, is connected by bridges 3905. Each strut includes a tether guide tube 3908. The distal end of activation tether is passed through the guide tube 3908. The microcatheter 3901 is retracted and the activation tethers 3904 are manually pulled proximally to compress the device proximally and to allow ring elements 3902 to reach the expanded configuration 3900b.

FIGS. 66a-66c illustrates a mechanical clot retrieval device 3920a of the present invention which is a slightly variant embodiment of the retrieval device shown in FIGS. 61a-61c. The retrieval device 3920a is advanced through a microcatheter 3921 inside the patient artery and has a pair of activation tethers 3924 having distal ends that extend interior of the artery and proximal ends that extend exterior of the artery, a distal collar 3927, and a plurality of ring elements 3922 configured to the distal end of the activation tether 3824. The ring elements 3922 are self-expandable from a collapsed configuration 3920a to an expanded configuration 3920b and comprise a radial force that biases the ring elements 3922 in the expanded configuration 3920b. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3921 through which the retrieval device 3920a is delivered inside the artery. Each ring element 3922 comprising a plurality of struts 3923 and a limiting tether 3928 is interconnected by bridges 3925. The microcatheter 3921 is retracted and the activation tether 3924 is manually pulled proximally to compress the device and to allow ring elements 3922 to reach the expanded configuration 3920b. The limiting tether 3928 prevents the ring element from expanding beyond a certain diameter.

FIGS. 67a-67b shows a mechanical clot retrieval device 3940 of the present invention which is a slightly variant embodiment of the retrieval device 3840 as illustrated in FIGS. 62a-62b. The retrieval device 3940 is advanced through a microcatheter 3941 inside the patient artery and has an activation tether 3944 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a distal collar 3947, and a ring element 3946 configured at the distal end of the activation tether 3944. The ring element 3946 is self-expandable from a collapsed configuration to an expanded configuration and has a radial force that biases the ring element 3946 to the expanded configuration. The ring element comprising a plurality of struts 3943 and a limiting tether 3948. The microcatheter 3941 is retracted and the activation tether 3944 is manually pulled proximally to compress the device and to allow ring elements 3942 to reach the expanded configuration.

FIGS. 68a-68b shows a mechanical clot retrieval device 3960 of the present invention which is a slightly variant embodiment of the retrieval device 3860 as illustrated in FIGS. 63a-63b. The retrieval device 3962 is advanced through a microcatheter 3961 inside the artery and has an activation tether 3964 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a distal collar 3967, a ring element 3966 configured at the distal end of the activation tether 3964, and a pair of removal tethers 3962 attached to the ring element 3966 having proximal ends that extend exterior of the artery. The ring element 3966 is self-expandable from a collapsed configuration to an expanded configuration and has a radial force that biases the ring element 3966 to the expanded configuration. In the collapsed configuration, the radial force is absorbed by the microcatheter 3961. Each ring element 3966 comprises a plurality of struts 3963 and a limiting tether 3968. The microcatheter 3961 is retracted and the activation tether 3964 is manually pulled proximally to compress the device and allow ring elements 3966 to reach the expanded configuration.

FIGS. 69a-69b shows a mechanical clot retrieval device 3980 of the present invention which is a slightly variant embodiment of the retrieval device 3880 as illustrated in FIGS. 64a-64b. The retrieval device 3980 is advanced through a microcatheter 3981 inside the artery and has an activation tether 3984 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a couple of collars 3987, a couple of ring elements 3986 configured at the distal end of the activation tether 3984, and a pair of removal tethers 3982 having distal ends attached to the ring element 3986. The ring element 3986 is self-expandable from a collapsed configuration to an expanded configuration and has a radial force that biases the ring element 3986 to the expanded configuration. In the collapsed configuration, the radial force is absorbed by the microcatheter 3981. Each ring element comprises a plurality of struts 3983 and a limiting tether 3988. The microcatheter 3981 is retracted and the activation tether 3984 is manually pulled proximally to compress the device and allow the ring elements 3986 reach the expanded configuration.

The ring elements used in the above description are made of shape-memory material, preferably Nitinol. Remaining elements of the retrieval device as described herein are preferably formed of a material such as a stainless steel, a nickel-based super alloy, a spring steel alloy, particularly a composition sold under the trademark nitinol.

It will be apparent from the foregoing description that, while particular embodiments of the present invention have been illustrated and described, various modifications can be made without departing from the spirit and scope of the invention.

Modifications and additions can be made to the various embodiments of the invention described herein. For example, while embodiments may refer to particular features, the invention includes embodiments having different combinations of features. The invention also includes embodiments that do not include all of the specific features described.

The invention is not limited to the embodiments hereinbefore described which may be varied in construction and detail.

Claims

1. A clot retrieval device for removing a clot from a blood vessel, comprising: a plurality of ring elements comprising: one or more distal apices;one or more proximal apices offset from the one or more distal apices; anda plurality of struts forming one or more closed cells having one or more crown elements, wherein the plurality of ring elements are attached together by connecting tethers at connection points including at at least the one or more proximal apices; anda plurality of openings through which the clot may pass and enter the device, each opening being disposed between respective ring elements;wherein each ring element being self-expandable from a collapsed configuration to an expanded configuration wherein a radial force biases the ring elements toward the expanded configuration; andwherein at least one of the crown elements terminates in an apex away from a center axis of the device.
2. The device of claim 1, wherein adjacent struts of the plurality of struts of each of the plurality of ring elements couple to one another in the collapsed configuration and uncouple from one another in the expanded configuration.
3. The device of claim 1, wherein in the expanded configuration, a distal end of at least one end of the ring elements extends radially outwardly.
4. The device of claim 1, wherein the one or more distal apices and the one or more proximal apices are offset from each other in a sinusoidal configuration.
5. A clot retrieval device comprising: a plurality of clot engaging ring elements, the plurality of clot engaging ring elements comprising distal apices, proximal apices offset from the distal apices, and struts connected between respective distal and proximal apices of respective clot engaging ring elements, each clot engaging ring element being expandable between a retracted delivery configuration and an expanded deployed configuration,wherein the plurality of clot engaging ring elements are attached together by connecting tethers at connection points including at at least the proximal apices, andwherein to move to the expanded deployed configuration from the retracted delivery configuration, a shaft is axially translated thereby applying a radial force that biases the plurality of clot engaging ring elements to expand to the expanded deployed configuration.
6. The device of claim 5, further comprising: the shaft extending between a proximal end and a distal end, the clot engaging ring elements being connected to the distal end of the shaft.
7. The device of claim 5, wherein respective struts of respective clot engaging ring elements are connected through the connecting tethers.
8. The device of claim 5, wherein each of the clot engaging ring elements comprise a collar and an interior circumferential surface.
9. The device of claim 5, wherein each of the plurality of clot engaging ring elements is connected to at least one other of the plurality of clot engaging ring elements.
10. The device of claim 5, wherein in the expanded deployed configuration, a clot inlet opening is defined between the distal side of a first clot engaging ring element and a second adjacent clot engaging ring element.
11. The device of claim 5, wherein adjacent struts of the struts of each of the plurality of clot engaging ring elements couple to one another in the retracted delivery configuration and uncouple from one another in the expanded deployed configuration.
12. The device of claim 11, wherein connectors of the adjacent struts of the struts of each of the plurality of clot engaging ring elements include hooks.
13. The device of claim 5, wherein, in a partially deployed configuration, a distal end of at least one of the plurality of clot engaging ring elements tapers radially outwardly.
14. The device of claim 13, further including a tube, wherein the shaft is axially translatable within a lumen of the tube.
15. The device of claim 14, wherein the tube includes a proximal collar.
16. A clot retrieval device comprising: a shaft extending between a proximal end and a distal end;at least three clot engaging ring elements, the clot engaging ring elements comprising one or more distal apices, one or more proximal apices offset from the one or more distal apices, and struts connected through one or more connectors, each clot engaging ring element being expandable between a retracted delivery configuration and an expanded deployed configuration,wherein the at least three clot engaging ring elements are attached together by connecting tethers at connection points including at at least the one or more proximal apices,wherein in the retracted delivery configuration, the at least three clot engaging ring elements are configured to radially surround the shaft; andwherein to move to the expanded deployed configuration from the retracted delivery configuration, the shaft is axially translated thereby biasing the at least three clot engaging ring elements to expand to the expanded deployed configuration.
17. The device of claim 16, wherein the connecting tethers are disposed between a distal side of a first clot engaging ring element of the at least three clot engaging ring elements, and a proximal side of a second adjacent clot engaging ring element of the at least three clot engaging ring elements.
18. The device of claim 16, wherein in the expanded deployed configuration, a clot inlet opening is defined between each adjacent clot engaging ring element.
19. The device of claim 16, wherein the clot engaging ring elements comprise one or more crown elements that terminate in an apex away from a center axis of the device, wherein in the expanded deployed configuration, a clot inlet opening for receiving a clot is defined between distal and proximal sides of each adjacent clot engaging ring element.
20. The device of claim 16, wherein adjacent struts of the struts of each of the at least three clot engaging ring elements couple to one another in the retracted delivery configuration and uncouple from one another in the expanded deployed configuration.
21. The device of claim 16, further including a microcatheter, wherein the shaft is axially translatable within a lumen of the microcatheter.
22. The device of claim 16, wherein one or more tethers are connected to the shaft.

CROSS REFERENCE TO RELATED APPLICATIONS

The present application is a continuation application of U.S. patent application Ser. No. 15/226,389 filed Aug. 2, 2016, which is a continuation application of U.S. patent application Ser. No. 13/829,684 filed Mar. 14, 2013, now U.S. Pat. No. 9,433,429 issued Sep. 6, 2016. The entire contents of which are hereby incorporated by reference.

US Referenced Citations (881)

Number	Name	Date	Kind
4455717	Gray	Jun 1984	A
4611594	Grayhack et al.	Sep 1986	A
4612931	Dormia	Sep 1986	A
4727873	Mobin-Uddin	Mar 1988	A
4793348	Palmaz	Dec 1988	A
4873978	Ginsburg	Oct 1989	A
5011488	Ginsburg	Apr 1991	A
5084065	MacGregor et al.	Jan 1992	A
5092839	Kipperman	Mar 1992	A
5100423	Fearnot	Mar 1992	A
5102415	Guenther et al.	Apr 1992	A
5108419	Reger et al.	Apr 1992	A
5122136	Guglielmi et al.	Jun 1992	A
5163951	Pinchuk et al.	Nov 1992	A
5171233	Amplatz	Dec 1992	A
5171259	Inoue	Dec 1992	A
5217441	Shichman	Jun 1993	A
5234437	Sepetka	Aug 1993	A
5236447	Kubo et al.	Aug 1993	A
5330482	Gibbs et al.	Jul 1994	A
5383887	Nadal	Jan 1995	A
5387219	Rappe	Feb 1995	A
5387226	Miraki	Feb 1995	A
5449372	Schmaltz	Sep 1995	A
5499985	Hein et al.	Mar 1996	A
5538512	Zenzon et al.	Jul 1996	A
5538515	Kafry et al.	Jul 1996	A
5549626	Miller et al.	Aug 1996	A
5558652	Henke	Sep 1996	A
5609627	Goicoechea et al.	Mar 1997	A
5624461	Mariant	Apr 1997	A
5639277	Mariant	Jun 1997	A
5639278	Dereume et al.	Jun 1997	A
5645558	Horton	Jul 1997	A
5653605	Woehl et al.	Aug 1997	A
5658296	Bates	Aug 1997	A
5665117	Rhodes	Sep 1997	A
5695519	Summer et al.	Dec 1997	A
5709704	Nott et al.	Jan 1998	A
5713853	Clark	Feb 1998	A
5769871	Mers Kelly	Jun 1998	A
5769884	Solovay	Jun 1998	A
5779686	Sato et al.	Jul 1998	A
5779716	Cano	Jul 1998	A
5800519	Sandock	Sep 1998	A
5810874	Lefebvre	Sep 1998	A
5814064	Daniel et al.	Sep 1998	A
5827304	Hart	Oct 1998	A
5853422	Huebsch et al.	Dec 1998	A
5855598	Pinchuk	Jan 1999	A
5893869	Barnhart et al.	Apr 1999	A
5895398	Wensel	Apr 1999	A
5897567	Ressemann	Apr 1999	A
5904698	Thomas et al.	May 1999	A
5911702	Romley et al.	Jun 1999	A
5911725	Boury	Jun 1999	A
5919126	Armini	Jul 1999	A
5931509	Bartholomew	Aug 1999	A
5935139	Bates	Aug 1999	A
5947995	Samuels	Sep 1999	A
6063113	Kavteladze	May 2000	A
6066149	Samson et al.	May 2000	A
6066158	Engelson	May 2000	A
6093196	Okada	Jul 2000	A
6093199	Brown et al.	Jul 2000	A
6096053	Bates	Aug 2000	A
6099534	Bates	Aug 2000	A
6099559	Nolting	Aug 2000	A
6102932	Kurz	Aug 2000	A
6106548	Roubin et al.	Aug 2000	A
6129739	Khosravi	Oct 2000	A
6143022	Shull et al.	Nov 2000	A
6146404	Kim	Nov 2000	A
6156064	Chouinard	Dec 2000	A
6165194	Denardo	Dec 2000	A
6165199	Barbut	Dec 2000	A
6168604	Cano	Jan 2001	B1
6168622	Mazzocchi	Jan 2001	B1
6174318	Bates et al.	Jan 2001	B1
6179861	Khosravi	Jan 2001	B1
6203561	Ramee	Mar 2001	B1
6214026	Lepak	Apr 2001	B1
6221006	Dubrul	Apr 2001	B1
6221096	Aiba	Apr 2001	B1
6231597	Deem et al.	May 2001	B1
6238412	Dubrul	May 2001	B1
6245012	Kleshinski	Jun 2001	B1
6245087	Addis	Jun 2001	B1
6251122	Tsu Kernik	Jun 2001	B1
6254571	Hart	Jul 2001	B1
6264663	Cano	Jul 2001	B1
6267777	Bosma et al.	Jul 2001	B1
6290710	Cryer et al.	Sep 2001	B1
6312444	Barbut	Nov 2001	B1
6315778	Gambale et al.	Nov 2001	B1
6325815	Kusleika et al.	Dec 2001	B1
6325819	Pavcnik et al.	Dec 2001	B1
6334864	Amplatz et al.	Jan 2002	B1
6336934	Gilson et al.	Jan 2002	B1
6346116	Brooks et al.	Feb 2002	B1
6348056	Bates	Feb 2002	B1
6350271	Kurz et al.	Feb 2002	B1
6355057	DeMarais et al.	Mar 2002	B1
6361545	Macoviak	Mar 2002	B1
6364895	Greenhalgh	Apr 2002	B1
6375668	Gifford et al.	Apr 2002	B1
6375670	Greenhalgh	Apr 2002	B1
6383205	Samson et al.	May 2002	B1
6383206	Gillick	May 2002	B1
6391037	Greenhalgh	May 2002	B1
6402771	Palmer	Jun 2002	B1
6416541	Denardo	Jul 2002	B2
6425909	Dieck et al.	Jul 2002	B1
6428558	Jones et al.	Aug 2002	B1
6432122	Gilson et al.	Aug 2002	B1
6436112	Wensel	Aug 2002	B2
6458139	Palmer	Oct 2002	B1
6485497	Wensel	Nov 2002	B2
6485501	Green	Nov 2002	B1
6485502	Don Michael	Nov 2002	B2
6488701	Nolting et al.	Dec 2002	B1
6511492	Rosenbluth	Jan 2003	B1
6530935	Wensel	Mar 2003	B2
6530939	Hopkins	Mar 2003	B1
6540768	Diaz et al.	Apr 2003	B1
6544279	Hopkins	Apr 2003	B1
6551341	Boylan et al.	Apr 2003	B2
6551342	Shen et al.	Apr 2003	B1
6575996	Denison et al.	Jun 2003	B1
6575997	Palmer et al.	Jun 2003	B1
6582448	Boyle	Jun 2003	B1
6585756	Strecker	Jul 2003	B1
6589265	Palmer et al.	Jul 2003	B1
6592607	Palmer et al.	Jul 2003	B1
6592614	Lenker et al.	Jul 2003	B2
6592616	Stack	Jul 2003	B1
6602265	Dubrul et al.	Aug 2003	B2
6602271	Adams	Aug 2003	B2
6602272	Boylan et al.	Aug 2003	B2
6605102	Mazzocchi et al.	Aug 2003	B1
6610077	Hancock et al.	Aug 2003	B1
6616679	Khosravi	Sep 2003	B1
6632241	Hancock et al.	Oct 2003	B1
6638245	Miller	Oct 2003	B2
6638293	Makower et al.	Oct 2003	B1
6641590	Palmer et al.	Nov 2003	B1
6656218	Denardo et al.	Dec 2003	B1
6660021	Palmer et al.	Dec 2003	B1
6663650	Sepetka	Dec 2003	B2
6673089	Yassour et al.	Jan 2004	B1
6685722	Rosenbluth	Feb 2004	B1
6692504	Kurz et al.	Feb 2004	B2
6692508	Wensel	Feb 2004	B2
6692509	Wensel	Feb 2004	B2
6695858	Dubrul et al.	Feb 2004	B1
6702782	Miller	Mar 2004	B2
6709465	Mitchell et al.	Mar 2004	B2
6712834	Yassour et al.	Mar 2004	B2
6726701	Gilson et al.	Apr 2004	B2
6726703	Broome et al.	Apr 2004	B2
6730104	Sepetka	May 2004	B1
6783528	Vincent-Prestigiacomo	Aug 2004	B2
6783538	McGuckin, Jr. et al.	Aug 2004	B2
6824545	Sepetka	Nov 2004	B2
6855155	Denardo et al.	Feb 2005	B2
6878163	Denardo et al.	Apr 2005	B2
6890340	Duane	May 2005	B2
6913612	Palmer	Jul 2005	B2
6913618	Denardo et al.	Jul 2005	B2
6939361	Kleshinski	Sep 2005	B1
6953472	Palmer et al.	Oct 2005	B2
6989019	Mazzocchi	Jan 2006	B2
6989021	Bosma et al.	Jan 2006	B2
6994718	Groothuis et al.	Feb 2006	B2
7004954	Voss et al.	Feb 2006	B1
7004955	Shen	Feb 2006	B2
7004956	Palmer	Feb 2006	B2
7008434	Kurz et al.	Mar 2006	B2
7033376	Tsukemik	Apr 2006	B2
7041116	Goto	May 2006	B2
7048758	Boyle	May 2006	B2
7052500	Bashiri et al.	May 2006	B2
7058456	Pierce	Jun 2006	B2
7063707	Bose	Jun 2006	B2
7083633	Morrill et al.	Aug 2006	B2
7083822	Brightbill	Aug 2006	B2
7094249	Broome et al.	Aug 2006	B1
7097653	Freudenthal et al.	Aug 2006	B2
7101380	Khachin et al.	Sep 2006	B2
7172614	Boyle et al.	Feb 2007	B2
7175655	Malaei	Feb 2007	B1
7179273	Palmer et al.	Feb 2007	B1
7185922	Takayanagi et al.	Mar 2007	B2
7220271	Clubb	May 2007	B2
7226464	Garner et al.	Jun 2007	B2
7229472	DePalma et al.	Jun 2007	B2
7241304	Boyle et al.	Jul 2007	B2
7288112	Denardo et al.	Oct 2007	B2
7300458	Henkes et al.	Nov 2007	B2
7306618	Demond	Dec 2007	B2
7314483	Landau et al.	Jan 2008	B2
7316692	Huffmaster	Jan 2008	B2
7323001	Clubb	Jan 2008	B2
7331976	McGuckin, Jr. et al.	Feb 2008	B2
7344550	Garrison et al.	Mar 2008	B2
7399308	Borillo et al.	Jul 2008	B2
7410491	Hopkins	Aug 2008	B2
7425215	Boyle et al.	Sep 2008	B2
7452496	Brady et al.	Nov 2008	B2
7491215	Vale et al.	Feb 2009	B2
7491216	Brady	Feb 2009	B2
7510565	Gilson et al.	Mar 2009	B2
7534252	Sepetka	May 2009	B2
7556636	Mazzocchi	Jul 2009	B2
7582111	Krolik et al.	Sep 2009	B2
7594926	Linder	Sep 2009	B2
7604649	McGuckin et al.	Oct 2009	B2
7604650	Bergheim	Oct 2009	B2
7618434	Santra	Nov 2009	B2
7662165	Gilson et al.	Feb 2010	B2
7670356	Mazzocchi	Mar 2010	B2
7678123	Chanduszko	Mar 2010	B2
7691121	Rosenbluth	Apr 2010	B2
7691124	Balgobin	Apr 2010	B2
7708770	Linder	May 2010	B2
7717929	Fallman	May 2010	B2
7736385	Agnew	Jun 2010	B2
7758606	Streeter et al.	Jul 2010	B2
7758611	Kato	Jul 2010	B2
7766934	Pal	Aug 2010	B2
7771452	Pal	Aug 2010	B2
7780694	Palmer	Aug 2010	B2
7780700	Frazier et al.	Aug 2010	B2
7811305	Balgobin et al.	Oct 2010	B2
7815659	Conlon et al.	Oct 2010	B2
7819893	Brady et al.	Oct 2010	B2
7828815	Mazzocchi	Nov 2010	B2
7828816	Mazzocchi et al.	Nov 2010	B2
7833240	Okushi et al.	Nov 2010	B2
7842053	Chanduszko et al.	Nov 2010	B2
7846176	Mazzocchi	Nov 2010	B2
7846175	Bonnette et al.	Dec 2010	B2
7850708	Pal	Dec 2010	B2
7883516	Huang et al.	Feb 2011	B2
7887560	Kusleika	Feb 2011	B2
7901426	Gilson et al.	Mar 2011	B2
7914549	Morsi	Mar 2011	B2
7922732	Mazzocchi	Apr 2011	B2
7927784	Simpson	Apr 2011	B2
7931659	Bose et al.	Apr 2011	B2
7998165	Huffmaster	Aug 2011	B2
8002822	Glocker et al.	Aug 2011	B2
8021379	Thompson et al.	Sep 2011	B2
8021380	Thompson et al.	Sep 2011	B2
8043326	Hancock et al.	Oct 2011	B2
8048151	O'Brien et al.	Nov 2011	B2
8052640	Fiorella et al.	Nov 2011	B2
8057497	Raju et al.	Nov 2011	B1
8057507	Horan et al.	Nov 2011	B2
8066757	Ferrera et al.	Nov 2011	B2
8070791	Ferrera et al.	Dec 2011	B2
8088140	Ferrera et al.	Jan 2012	B2
8100935	Rosenbluth et al.	Jan 2012	B2
8109941	Richardson	Feb 2012	B2
8118829	Garrison et al.	Feb 2012	B2
8118856	Schreck et al.	Feb 2012	B2
8123769	Osborne	Feb 2012	B2
8137376	Clubb et al.	Mar 2012	B2
8137377	Palmer et al.	Mar 2012	B2
8142422	Makower et al.	Mar 2012	B2
8142442	Palmer et al.	Mar 2012	B2
8182508	Magnuson et al.	May 2012	B2
8187298	Pal	May 2012	B2
8246641	Osborne et al.	Aug 2012	B2
8246672	Osborne	Aug 2012	B2
8252017	Paul, Jr. et al.	Aug 2012	B2
8252018	Valaie	Aug 2012	B2
8262689	Schneiderman et al.	Sep 2012	B2
8282668	McGuckin, Jr. et al.	Oct 2012	B2
8298257	Sepetka et al.	Oct 2012	B2
RE43882	Hopkins et al.	Dec 2012	E
8357178	Grandfield et al.	Jan 2013	B2
8357179	Grandfield et al.	Jan 2013	B2
8357180	Feller, III et al.	Jan 2013	B2
8357893	Xu	Jan 2013	B2
8361095	Osborne	Jan 2013	B2
8361110	Chanduszko	Jan 2013	B2
8366663	Fiorella et al.	Feb 2013	B2
8409215	Sepetka et al.	Apr 2013	B2
8414482	Belson	Apr 2013	B2
8414543	McGuckin, Jr. et al.	Apr 2013	B2
8419748	Valaie	Apr 2013	B2
8460312	Bose et al.	Jun 2013	B2
8460313	Huffmaster	Jun 2013	B2
8486104	Samson et al.	Jul 2013	B2
8512352	Martin	Aug 2013	B2
8529596	Grandfield et al.	Sep 2013	B2
8545526	Martin et al.	Oct 2013	B2
8574262	Ferrera et al.	Nov 2013	B2
8579915	French et al.	Nov 2013	B2
8585713	Ferrera et al.	Nov 2013	B2
8608761	Osborne et al.	Dec 2013	B2
8679142	Slee et al.	Mar 2014	B2
8690907	Janardhan et al.	Apr 2014	B1
8696622	Fiorella et al.	Apr 2014	B2
8702652	Fiorella et al.	Apr 2014	B2
8702704	Shelton, IV et al.	Apr 2014	B2
8702724	Olsen et al.	Apr 2014	B2
8777976	Brady et al.	Jul 2014	B2
8777979	Shrivastava et al.	Jul 2014	B2
8784434	Rosenbluth et al.	Jul 2014	B2
8784441	Rosenbluth et al.	Jul 2014	B2
8795305	Grandfield et al.	Aug 2014	B2
8795317	Grandfield et al.	Aug 2014	B2
8795345	Grandfield et al.	Aug 2014	B2
8814892	Galdonik et al.	Aug 2014	B2
8814925	Hilaire et al.	Aug 2014	B2
8852205	Brady et al.	Oct 2014	B2
8870941	Evans et al.	Oct 2014	B2
8900265	Ulm, III	Dec 2014	B1
8920358	Levine et al.	Dec 2014	B2
8939991	Krolick et al.	Jan 2015	B2
8945143	Ferrera et al.	Feb 2015	B2
8945160	Krolik et al.	Feb 2015	B2
8945169	Pal	Feb 2015	B2
8945172	Ferrera et al.	Feb 2015	B2
8956399	Cam et al.	Feb 2015	B2
8968330	Rosenbluth et al.	Mar 2015	B2
9011481	Aggerholm et al.	Apr 2015	B2
9039749	Shrivastava et al.	May 2015	B2
9072537	Grandfield et al.	Jul 2015	B2
9095342	Becking et al.	Aug 2015	B2
9113936	Palmer et al.	Aug 2015	B2
9119656	Bose et al.	Sep 2015	B2
9138307	Valaie	Sep 2015	B2
9155552	Ulm, III	Oct 2015	B2
9161758	Figulla et al.	Oct 2015	B2
9161766	Slee et al.	Oct 2015	B2
9173668	Ulm, III	Nov 2015	B2
9186487	Dubrul et al.	Nov 2015	B2
9198687	Fulkerson et al.	Dec 2015	B2
9204887	Cully et al.	Dec 2015	B2
9211132	Bowman	Dec 2015	B2
9221132	Bowman	Dec 2015	B2
9232992	Heidner et al.	Jan 2016	B2
9254371	Martin et al.	Feb 2016	B2
9301769	Brady et al.	Apr 2016	B2
9332999	Ray et al.	May 2016	B2
9402707	Brady et al.	Aug 2016	B2
9445829	Brady et al.	Sep 2016	B2
9456834	Folk	Oct 2016	B2
9532792	Galdonik et al.	Jan 2017	B2
9532873	Kelley	Jan 2017	B2
9533344	Monetti et al.	Jan 2017	B2
9539011	Chen et al.	Jan 2017	B2
9539022	Bowman	Jan 2017	B2
9539122	Burke et al.	Jan 2017	B2
9539382	Nelson	Jan 2017	B2
9549830	Bruszewski et al.	Jan 2017	B2
9554805	Tompkins et al.	Jan 2017	B2
9561125	Bowman et al.	Feb 2017	B2
9572982	Burnes et al.	Feb 2017	B2
9579104	Beckham et al.	Feb 2017	B2
9579484	Barnell	Feb 2017	B2
9585642	Dinsmoor et al.	Mar 2017	B2
9615832	Bose et al.	Apr 2017	B2
9615951	Bennett et al.	Apr 2017	B2
9622753	Cox	Apr 2017	B2
9636115	Henry et al.	May 2017	B2
9636439	Chu et al.	May 2017	B2
9642639	Brady et al.	May 2017	B2
9642675	Werneth et al.	May 2017	B2
9655633	Leynov et al.	May 2017	B2
9655645	Staunton	May 2017	B2
9655989	Cruise et al.	May 2017	B2
9662129	Galdonik et al.	May 2017	B2
9662238	Dwork et al.	May 2017	B2
9662425	Lilja et al.	May 2017	B2
9668898	Wong	Jun 2017	B2
9675477	Thompson	Jun 2017	B2
9675782	Connolly	Jun 2017	B2
9676022	Ensign et al.	Jun 2017	B2
9692557	Murphy	Jun 2017	B2
9693852	Lam et al.	Jul 2017	B2
9700262	Janik et al.	Jul 2017	B2
9700399	Acosta-Acevedo	Jul 2017	B2
9717421	Griswold et al.	Aug 2017	B2
9717500	Tieu et al.	Aug 2017	B2
9717502	Teoh et al.	Aug 2017	B2
9724103	Cruise et al.	Aug 2017	B2
9724526	Strother et al.	Aug 2017	B2
9750565	Bloom et al.	Sep 2017	B2
9757260	Greenan	Sep 2017	B2
9764111	Gulachenski	Sep 2017	B2
9770251	Bowman et al.	Sep 2017	B2
9770577	Li et al.	Sep 2017	B2
9775621	Tompkins et al.	Oct 2017	B2
9775706	Peterson et al.	Oct 2017	B2
9775732	Khenansho	Oct 2017	B2
9788800	Mayoras, Jr.	Oct 2017	B2
9795391	Saatchi et al.	Oct 2017	B2
9801980	Karino et al.	Oct 2017	B2
9808599	Bowman et al.	Nov 2017	B2
9833252	Sepetka et al.	Dec 2017	B2
9833304	Horan et al.	Dec 2017	B2
9833604	Lam et al.	Dec 2017	B2
9833625	Waldhauser et al.	Dec 2017	B2
9901434	Hoffman	Feb 2018	B2
9918720	Marchand et al.	Mar 2018	B2
10016206	Yang	Jul 2018	B1
10070878	Ma	Sep 2018	B2
10098651	Marchand et al.	Oct 2018	B2
10201360	Vale et al.	Feb 2019	B2
10231751	Sos	Mar 2019	B2
10292723	Brady et al.	May 2019	B2
10299811	Brady et al.	May 2019	B2
10363054	Vale et al.	Jul 2019	B2
10376274	Farin et al.	Aug 2019	B2
10390850	Vale et al.	Aug 2019	B2
10524811	Marchand et al.	Jan 2020	B2
10617435	Vale et al.	Apr 2020	B2
10722257	Skillrud et al.	Jul 2020	B2
20010001315	Bates	May 2001	A1
20010016755	Addis	Aug 2001	A1
20010037141	Yee et al.	Nov 2001	A1
20010041909	Tsugita et al.	Nov 2001	A1
20010049554	Ruiz et al.	Dec 2001	A1
20010051810	Dubrul	Dec 2001	A1
20020004667	Adams et al.	Jan 2002	A1
20020016609	Wensel	Feb 2002	A1
20020022859	Hogendijk	Feb 2002	A1
20020026211	Khosravi	Feb 2002	A1
20020042627	Brady et al.	Apr 2002	A1
20020049468	Streeter	Apr 2002	A1
20020052620	Barbut	May 2002	A1
20020058911	Gilson et al.	May 2002	A1
20020068954	Foster	Jun 2002	A1
20020072764	Sepetka	Jun 2002	A1
20020082558	Samson	Jun 2002	A1
20020091407	Zadno-Azizi et al.	Jul 2002	A1
20020095171	Belef	Jul 2002	A1
20020123765	Sepetka	Sep 2002	A1
20020138094	Borillo	Sep 2002	A1
20020143349	Gifford, III et al.	Oct 2002	A1
20020143362	Macoviak et al.	Oct 2002	A1
20020156455	Barbut	Oct 2002	A1
20020161393	Demond	Oct 2002	A1
20020165576	Boyle et al.	Nov 2002	A1
20020173819	Leeflang et al.	Nov 2002	A1
20020183787	Wahr et al.	Dec 2002	A1
20020188276	Evans	Dec 2002	A1
20020188314	Anderson et al.	Dec 2002	A1
20020193824	Boylan et al.	Dec 2002	A1
20020198588	Armstrong et al.	Dec 2002	A1
20030004536	Boylan et al.	Jan 2003	A1
20030004538	Secrest	Jan 2003	A1
20030004540	Linder et al.	Jan 2003	A1
20030004542	Wensel	Jan 2003	A1
20030009146	Muni	Jan 2003	A1
20030009191	Wensel	Jan 2003	A1
20030038447	Cantele	Feb 2003	A1
20030040772	Hyodoh et al.	Feb 2003	A1
20030050663	Khachin	Mar 2003	A1
20030064151	Klinedinst	Apr 2003	A1
20030114879	Euteneuer et al.	Jun 2003	A1
20030125798	Martin	Jul 2003	A1
20030130682	Broome et al.	Jul 2003	A1
20030144687	Brady et al.	Jul 2003	A1
20030144688	Brady et al.	Jul 2003	A1
20030153943	Michael et al.	Aug 2003	A1
20030153944	Phung	Aug 2003	A1
20030163064	Vrba	Aug 2003	A1
20030163158	White	Aug 2003	A1
20030171769	Barbut	Sep 2003	A1
20030171771	Anderson et al.	Sep 2003	A1
20030176884	Berrada et al.	Sep 2003	A1
20030187495	Cully et al.	Oct 2003	A1
20030195537	Dubrul	Oct 2003	A1
20030195554	Shen	Oct 2003	A1
20030199917	Knudson	Oct 2003	A1
20030204202	Palmer	Oct 2003	A1
20030208224	Broome	Nov 2003	A1
20030212430	Bose	Nov 2003	A1
20030236533	Wlson	Dec 2003	A1
20040064179	Linder et al.	Apr 2004	A1
20040068288	Palmer et al.	Apr 2004	A1
20040073243	Sepetka	Apr 2004	A1
20040079429	Miller	Apr 2004	A1
20040082962	Demarais et al.	Apr 2004	A1
20040082967	Broome et al.	Apr 2004	A1
20040088001	Bosma et al.	May 2004	A1
20040093065	Yachia et al.	May 2004	A1
20040098050	Foerster et al.	May 2004	A1
20040133231	Maitland	Jul 2004	A1
20040133232	Rosenbluth et al.	Jul 2004	A1
20040138692	Phung	Jul 2004	A1
20040153117	Clubb et al.	Aug 2004	A1
20040153118	Clubb	Aug 2004	A1
20040199201	Kellett et al.	Oct 2004	A1
20040215318	Kwitkin	Oct 2004	A1
20040220663	Rivelli, Jr.	Nov 2004	A1
20050033348	Sepetka	Feb 2005	A1
20050038447	Huffmaster	Feb 2005	A1
20050038468	Panetta et al.	Feb 2005	A1
20050043759	Chanduszko	Feb 2005	A1
20050049619	Sepetka	Mar 2005	A1
20050049669	Jones	Mar 2005	A1
20050049670	Jones et al.	Mar 2005	A1
20050055033	Leslie et al.	Mar 2005	A1
20050055047	Greenhalgh	Mar 2005	A1
20050059995	Sepetka	Mar 2005	A1
20050085849	Sepetka	Apr 2005	A1
20050090779	Osypka	Apr 2005	A1
20050090857	Kusleika et al.	Apr 2005	A1
20050125024	Sepetka	Jun 2005	A1
20050171566	Kanamaru	Aug 2005	A1
20050192627	Whisenant et al.	Sep 2005	A1
20050216030	Sepetka	Sep 2005	A1
20050216050	Sepetka	Sep 2005	A1
20050228417	Teitelbaum et al.	Oct 2005	A1
20050251206	Maahs et al.	Nov 2005	A1
20050251209	Saadat et al.	Nov 2005	A1
20050267491	Kellett et al.	Dec 2005	A1
20050273135	Chanduszko et al.	Dec 2005	A1
20050283186	Berrada et al.	Dec 2005	A1
20050288686	Sepetka	Dec 2005	A1
20060009798	Callister et al.	Jan 2006	A1
20060009799	Kleshinski et al.	Jan 2006	A1
20060020285	Niermann	Jan 2006	A1
20060020286	Niermann	Jan 2006	A1
20060030877	Martinez et al.	Feb 2006	A1
20060041228	Vo et al.	Feb 2006	A1
20060058836	Bose	Mar 2006	A1
20060058837	Bose	Mar 2006	A1
20060058838	Bose	Mar 2006	A1
20060064151	Guterman et al.	Mar 2006	A1
20060069424	Acosta	Mar 2006	A1
20060074477	Berthiaume	Apr 2006	A1
20060149313	Arguello et al.	Jul 2006	A1
20060155305	Freudenthal	Jul 2006	A1
20060161187	Levine et al.	Jul 2006	A1
20060195137	Sepetka	Aug 2006	A1
20060224177	Finitsis	Oct 2006	A1
20060224179	Kucharczyk	Oct 2006	A1
20060229638	Abrams et al.	Oct 2006	A1
20060235501	Igaki	Oct 2006	A1
20060241677	Johnson et al.	Oct 2006	A1
20060282111	Morsi	Dec 2006	A1
20060287668	Fawzi et al.	Dec 2006	A1
20060287701	Pal	Dec 2006	A1
20060293706	Shimon	Dec 2006	A1
20070010857	Sugimoto et al.	Jan 2007	A1
20070032879	Levine et al.	Feb 2007	A1
20070088382	Bei et al.	Apr 2007	A1
20070088383	Pal	Apr 2007	A1
20070100348	Cauthen, III et al.	May 2007	A1
20070118173	Magnuson et al.	May 2007	A1
20070149997	Muller	Jun 2007	A1
20070156170	Hancock	Jul 2007	A1
20070165170	Fukuda	Jul 2007	A1
20070179527	Eskuri et al.	Aug 2007	A1
20070191866	Palmer et al.	Aug 2007	A1
20070198028	Miloslayski	Aug 2007	A1
20070198051	Clubb et al.	Aug 2007	A1
20070198075	Levy	Aug 2007	A1
20070208367	Fiorella	Sep 2007	A1
20070208371	French	Sep 2007	A1
20070225749	Martin	Sep 2007	A1
20070233175	Zaver et al.	Oct 2007	A1
20070244505	Gilson et al.	Oct 2007	A1
20070270902	Slazas et al.	Nov 2007	A1
20070288054	Tanaka et al.	Dec 2007	A1
20080045881	Teitelbaum et al.	Feb 2008	A1
20080077227	Ouellette et al.	Mar 2008	A1
20080082107	Miller et al.	Apr 2008	A1
20080086190	Ta	Apr 2008	A1
20080091223	Pokorney	Apr 2008	A1
20080097386	Osypka	Apr 2008	A1
20080109031	Sepetka	May 2008	A1
20080109032	Sepetka	May 2008	A1
20080119886	Greenhalgh et al.	May 2008	A1
20080125798	Osborne et al.	May 2008	A1
20080177296	Sepetka	Jul 2008	A1
20080178890	Townsend et al.	Jul 2008	A1
20080183197	Sepetka	Jul 2008	A1
20080183198	Sepetka	Jul 2008	A1
20080183205	Sepetka	Jul 2008	A1
20080188876	Sepetka	Aug 2008	A1
20080188885	Sepetka	Aug 2008	A1
20080188887	Batiste	Aug 2008	A1
20080200946	Braun	Aug 2008	A1
20080200947	Kusleika et al.	Aug 2008	A1
20080215077	Sepetka	Sep 2008	A1
20080221600	Dieck et al.	Sep 2008	A1
20080228209	DeMello et al.	Sep 2008	A1
20080234706	Sepetka	Sep 2008	A1
20080243170	Jenson	Oct 2008	A1
20080255596	Jenson	Oct 2008	A1
20080262410	Jenson et al.	Oct 2008	A1
20080262528	Martin	Oct 2008	A1
20080262532	Martin	Oct 2008	A1
20080269871	Eli	Oct 2008	A1
20080275488	Fleming	Nov 2008	A1
20080275493	Farmiga	Nov 2008	A1
20080281350	Sepetka et al.	Nov 2008	A1
20080312681	Ansel	Dec 2008	A1
20090005858	Young et al.	Jan 2009	A1
20090024157	Anukhin	Jan 2009	A1
20090030443	Buser et al.	Jan 2009	A1
20090062841	Amplatz et al.	Mar 2009	A1
20090069828	Martin	Mar 2009	A1
20090076539	Valaie	Mar 2009	A1
20090088793	Bagaoisan et al.	Apr 2009	A1
20090088795	Cahill	Apr 2009	A1
20090105722	Fulkerson	Apr 2009	A1
20090105737	Fulkerson	Apr 2009	A1
20090105747	Chanduszko et al.	Apr 2009	A1
20090149881	Vale et al.	Jun 2009	A1
20090163851	Holloway et al.	Jun 2009	A1
20090177206	Lozier et al.	Jul 2009	A1
20090182336	Brenzel et al.	Jul 2009	A1
20090281610	Parker	Nov 2009	A1
20090281619	Le et al.	Nov 2009	A1
20090292297	Ferrere	Nov 2009	A1
20090292307	Razack	Nov 2009	A1
20090299393	Martin	Dec 2009	A1
20090299403	Chanduszko et al.	Dec 2009	A1
20090306702	Miloslavski	Dec 2009	A1
20090326636	Hashimoto et al.	Dec 2009	A1
20100004607	Wilson et al.	Jan 2010	A1
20100076482	Shu et al.	Mar 2010	A1
20100087850	Razack	Apr 2010	A1
20100087908	Hilaire	Apr 2010	A1
20100114017	Lenker	May 2010	A1
20100125326	Kalstad	May 2010	A1
20100125327	Agnew	May 2010	A1
20100191272	Keating	Jul 2010	A1
20100211094	Sargent, Jr.	Aug 2010	A1
20100268264	Bonnett et al.	Oct 2010	A1
20100268265	Krolik et al.	Oct 2010	A1
20100274277	Eaton	Oct 2010	A1
20100318178	Rapaport et al.	Dec 2010	A1
20100324649	Mattsson et al.	Dec 2010	A1
20100331949	Habib	Dec 2010	A1
20110009875	Grandfield et al.	Jan 2011	A1
20110009940	Grandfield et al.	Jan 2011	A1
20110009950	Grandfield et al.	Jan 2011	A1
20110015718	Schreck	Jan 2011	A1
20110022149	Cox et al.	Jan 2011	A1
20110040319	Fulton, III	Feb 2011	A1
20110054514	Arcand	Mar 2011	A1
20110054516	Keegan	Mar 2011	A1
20110060212	Slee et al.	Mar 2011	A1
20110060359	Hannes	Mar 2011	A1
20110054504	Wolf et al.	May 2011	A1
20110106137	Shimon	May 2011	A1
20110125181	Brady et al.	May 2011	A1
20110152920	Eckhouse et al.	Jun 2011	A1
20110160763	Ferrera et al.	Jun 2011	A1
20110166586	Sepetka et al.	Jul 2011	A1
20110184456	Grandfield et al.	Jul 2011	A1
20110196414	Porter et al.	Aug 2011	A1
20110202088	Eckhouse et al.	Aug 2011	A1
20110208233	McGuckin, Jr. et al.	Aug 2011	A1
20110213297	Aklog et al.	Sep 2011	A1
20110213393	Aklog et al.	Sep 2011	A1
20110213403	Aboytes	Sep 2011	A1
20110224707	Miloslavaski et al.	Sep 2011	A1
20110276120	Gilson et al.	Nov 2011	A1
20110319917	Ferrera et al.	Dec 2011	A1
20120022572	Braun et al.	Jan 2012	A1
20120041449	Eckhouse et al.	Feb 2012	A1
20120041474	Eckhouse et al.	Feb 2012	A1
20120059356	diPalma et al.	Mar 2012	A1
20120065660	Ferrera et al.	Mar 2012	A1
20120083823	Shrivastava et al.	Apr 2012	A1
20120083868	Shrivastava et al.	Apr 2012	A1
20120089216	Rapaport et al.	Apr 2012	A1
20120101510	Lenker et al.	Apr 2012	A1
20120123466	Porter et al.	May 2012	A1
20120143237	Cam et al.	Jun 2012	A1
20120150147	Leynov et al.	Jun 2012	A1
20120165858	Eckhouse et al.	Jun 2012	A1
20120165859	Eckhouse et al.	Jun 2012	A1
20120209312	Aggerholm et al.	Aug 2012	A1
20120215250	Grandfield et al.	Aug 2012	A1
20120277788	Cattaneo	Nov 2012	A1
20120283768	Cox et al.	Nov 2012	A1
20120296362	Cam et al.	Nov 2012	A1
20120316600	Ferrera et al.	Dec 2012	A1
20120330350	Jones et al.	Dec 2012	A1
20130030460	Marks et al.	Jan 2013	A1
20130030461	Marks et al.	Jan 2013	A1
20130046330	McIntosh et al.	Feb 2013	A1
20130046333	Jones et al.	Feb 2013	A1
20130046334	Jones et al.	Feb 2013	A1
20130116774	Strauss et al.	May 2013	A1
20130131614	Hassan et al.	May 2013	A1
20130144311	Fung et al.	Jun 2013	A1
20130144326	Brady et al.	Jun 2013	A1
20130158592	Porter	Jun 2013	A1
20130184739	Brady et al.	Jul 2013	A1
20130197567	Brady et al.	Aug 2013	A1
20130226146	Tekulve	Aug 2013	A1
20130268050	Wilson et al.	Oct 2013	A1
20130281788	Garrison	Oct 2013	A1
20130325051	Martin et al.	Dec 2013	A1
20130325055	Eckhouse et al.	Dec 2013	A1
20130325056	Eckhouse et al.	Dec 2013	A1
20130345739	Brady et al.	Dec 2013	A1
20140005712	Martin	Jan 2014	A1
20140005713	Bowman	Jan 2014	A1
20140046359	Bowman et al.	Feb 2014	A1
20140121672	Folk	May 2014	A1
20140128905	Molaei	May 2014	A1
20140134654	Rudel et al.	May 2014	A1
20140135812	Divino et al.	May 2014	A1
20140142598	Fulton, III	May 2014	A1
20140180122	Stigall et al.	Jun 2014	A1
20140180377	Bose et al.	Jun 2014	A1
20140180397	Gerberding et al.	Jun 2014	A1
20140194911	Johnson et al.	Jul 2014	A1
20140194919	Losordo et al.	Jul 2014	A1
20140200607	Sepetka et al.	Jul 2014	A1
20140200608	Brady et al.	Jul 2014	A1
20140236220	Inoue	Aug 2014	A1
20140243881	Lees et al.	Aug 2014	A1
20140257362	Eidenschink	Sep 2014	A1
20140276922	McLain et al.	Sep 2014	A1
20140277079	Vale et al.	Sep 2014	A1
20140303667	Cox et al.	Oct 2014	A1
20140309657	Ben-Ami	Oct 2014	A1
20140309673	Dacuycuy et al.	Oct 2014	A1
20140330302	Tekulve et al.	Nov 2014	A1
20140343585	Ferrera et al.	Nov 2014	A1
20140371769	Vale et al.	Dec 2014	A1
20140371779	Vale et al.	Dec 2014	A1
20140371780	Vale et al.	Dec 2014	A1
20140379023	Brady et al.	Dec 2014	A1
20150018859	Quick et al.	Jan 2015	A1
20150018860	Quick et al.	Jan 2015	A1
20150032144	Holloway	Jan 2015	A1
20150080937	Davidson	Mar 2015	A1
20150112376	Molaei et al.	Apr 2015	A1
20150133990	Davidson	May 2015	A1
20150150672	Ma	Jun 2015	A1
20150164523	Brady et al.	Jun 2015	A1
20150224133	Ohri et al.	Aug 2015	A1
20150250497	Marks et al.	Sep 2015	A1
20150257775	Gilvarry et al.	Sep 2015	A1
20150272716	Pinchuk et al.	Oct 2015	A1
20150297252	Miloslayski et al.	Oct 2015	A1
20150313617	Grandfield et al.	Nov 2015	A1
20150320431	Ulm, III	Nov 2015	A1
20150352325	Quick	Dec 2015	A1
20150359547	Vale et al.	Dec 2015	A1
20150366650	Zi et al.	Dec 2015	A1
20150374391	Quick et al.	Dec 2015	A1
20150374393	Brady et al.	Dec 2015	A1
20150374479	Vale	Dec 2015	A1
20160015402	Brady et al.	Jan 2016	A1
20160022296	Brady et al.	Jan 2016	A1
20160045298	Thinnes, Jr. et al.	Feb 2016	A1
20160066921	Seifert et al.	Mar 2016	A1
20160100928	Lees et al.	Apr 2016	A1
20160106448	Brady et al.	Apr 2016	A1
20160106449	Brady et al.	Apr 2016	A1
20160113663	Brady et al.	Apr 2016	A1
20160113664	Brady et al.	Apr 2016	A1
20160113665	Brady et al.	Apr 2016	A1
20160120558	Brady et al.	May 2016	A1
20160143653	Vale et al.	May 2016	A1
20160192953	Brady et al.	Jul 2016	A1
20160192954	Brady et al.	Jul 2016	A1
20160192955	Brady et al.	Jul 2016	A1
20160192956	Brady et al.	Jul 2016	A1
20160256180	Vale et al.	Sep 2016	A1
20160303381	Pierce et al.	Oct 2016	A1
20160317168	Brady et al.	Nov 2016	A1
20170007264	Cruise et al.	Jan 2017	A1
20170007265	Guo et al.	Jan 2017	A1
20170020542	Martin et al.	Jan 2017	A1
20170020670	Murray et al.	Jan 2017	A1
20170020700	Bienvenu et al.	Jan 2017	A1
20170027640	Kunis et al.	Feb 2017	A1
20170027692	Bonhoeffer et al.	Feb 2017	A1
20170027725	Argentine	Feb 2017	A1
20170035436	Morita	Feb 2017	A1
20170035567	Duffy	Feb 2017	A1
20170042548	Lam	Feb 2017	A1
20170049596	Schabert	Feb 2017	A1
20170056061	Ogle et al.	Mar 2017	A1
20170071614	Vale et al.	Mar 2017	A1
20170071737	Kelley	Mar 2017	A1
20170072452	Monetti et al.	Mar 2017	A1
20170079671	Morero et al.	Mar 2017	A1
20170079680	Bowman	Mar 2017	A1
20170079766	Wang et al.	Mar 2017	A1
20170079767	Leon-Yip	Mar 2017	A1
20170079812	Lam et al.	Mar 2017	A1
20170079817	Sepetka et al.	Mar 2017	A1
20170079819	Pung et al.	Mar 2017	A1
20170079820	Lam et al.	Mar 2017	A1
20170086851	Wallace et al.	Mar 2017	A1
20170086862	Vale et al.	Mar 2017	A1
20170086863	Brady et al.	Mar 2017	A1
20170086996	Peterson et al.	Mar 2017	A1
20170095259	Tompkins et al.	Apr 2017	A1
20170100126	Bowman et al.	Apr 2017	A1
20170100141	Morero et al.	Apr 2017	A1
20170100143	Grandfield	Apr 2017	A1
20170100183	Iaizzo et al.	Apr 2017	A1
20170105743	Vale et al.	Apr 2017	A1
20170112515	Brady et al.	Apr 2017	A1
20170112647	Sachar et al.	Apr 2017	A1
20170113023	Steingisser et al.	Apr 2017	A1
20170119409	Ma	May 2017	A1
20170143465	Ulm, III	May 2017	A1
20170147765	Mehta	May 2017	A1
20170150979	Ulm	Jun 2017	A1
20170151032	Loisel	Jun 2017	A1
20170165062	Rothstein	Jun 2017	A1
20170165065	Rothstein et al.	Jun 2017	A1
20170165454	Tuohy et al.	Jun 2017	A1
20170172581	Bose et al.	Jun 2017	A1
20170172766	Vong et al.	Jun 2017	A1
20170172772	Khenansho	Jun 2017	A1
20170189033	Sepetka et al.	Jul 2017	A1
20170189035	Porter	Jul 2017	A1
20170215902	Leynov et al.	Aug 2017	A1
20170216484	Cruise et al.	Aug 2017	A1
20170224350	Shimizu et al.	Aug 2017	A1
20170224355	Bowman et al.	Aug 2017	A1
20170224467	Piccagli et al.	Aug 2017	A1
20170224511	Dwork et al.	Aug 2017	A1
20170224953	Tran et al.	Aug 2017	A1
20170231749	Perkins et al.	Aug 2017	A1
20170252064	Staunton	Sep 2017	A1
20170265983	Lam et al.	Sep 2017	A1
20170281192	Tieu et al.	Oct 2017	A1
20170281331	Perkins et al.	Oct 2017	A1
20170281344	Costello	Oct 2017	A1
20170281909	Northrop et al.	Oct 2017	A1
20170281912	Melder et al.	Oct 2017	A1
20170290593	Cruise et al.	Oct 2017	A1
20170290654	Sethna	Oct 2017	A1
20170296324	Argentine	Oct 2017	A1
20170296325	Marrocco et al.	Oct 2017	A1
20170303939	Greenhalgh et al.	Oct 2017	A1
20170303942	Greenhalgh et al.	Oct 2017	A1
20170303947	Greenhalgh et al.	Oct 2017	A1
20170303948	Wallace et al.	Oct 2017	A1
20170304041	Argentine	Oct 2017	A1
20170304097	Corwin et al.	Oct 2017	A1
20170304595	Nagasrinivasa et al.	Oct 2017	A1
20170312109	Le	Nov 2017	A1
20170312484	Shipley et al.	Nov 2017	A1
20170316561	Helm et al.	Nov 2017	A1
20170319826	Bowman et al.	Nov 2017	A1
20170333228	Orth et al.	Nov 2017	A1
20170333236	Greenan	Nov 2017	A1
20170333678	Bowman et al.	Nov 2017	A1
20170340383	Bloom et al.	Nov 2017	A1
20170348014	Wallace et al.	Dec 2017	A1
20170348514	Guyon et al.	Dec 2017	A1
20180263650	Iwanami et al.	Sep 2018	A1
20180325537	Shamay et al.	Nov 2018	A1
20180326024	Prochazka et al.	Nov 2018	A1
20180344338	Brady et al.	Dec 2018	A1
20190000492	Casey et al.	Jan 2019	A1
20190015061	Liebeskind et al.	Jan 2019	A1
20190167284	Friedman et al.	Jun 2019	A1
20190239907	Brady et al.	Aug 2019	A1
20190292273	Hanotin et al.	Sep 2019	A1
20190374239	Martin et al.	Dec 2019	A1
20190380723	Grandfield et al.	Dec 2019	A1
20190388097	Girdhar et al.	Dec 2019	A1
20200009150	Chamorro Sanchez	Jan 2020	A1
20200085444	Vale et al.	Mar 2020	A1
20200100804	Casey et al.	Apr 2020	A1
20200297364	Choe et al.	Sep 2020	A1

Foreign Referenced Citations (103)

Number	Date	Country
2557083	Jun 2003	CN
101172051	May 2008	CN
102307613	Jan 2012	CN
102596098	Jul 2012	CN
103764049	Apr 2014	CN
104042304	Sep 2014	CN
105208950	Dec 2015	CN
105662532	Jun 2016	CN
205359559	Jul 2016	CN
107530090	Jan 2018	CN
208582467	Mar 2019	CN
202009001951	Apr 2010	DE
102009056450	Jun 2011	DE
102010010849	Sep 2011	DE
10 2010 014778	Oct 2011	DE
102010024085	Dec 2011	DE
102011014586	Sep 2012	DE
1153581	Nov 2001	EP
2301450	Nov 2011	EP
2438891	Apr 2012	EP
2628455	Aug 2013	EP
3156004	Apr 2017	EP
2427554	Jan 2007	GB
2494820	Mar 2013	GB
0919438	Jan 1997	JP
2014-511223	May 2014	JP
2014-525796	Oct 2014	JP
2015-505250	Feb 2015	JP
2016-513505	May 2016	JP
2019-526365	Sep 2019	JP
WO 9424926	Nov 1994	WO
WO 9727808	Aug 1997	WO
WO 9738631	Oct 1997	WO
WO 9920335	Apr 1999	WO
WO 9960933	Dec 1999	WO
WO 9956801	Apr 2000	WO
WO 0121077	Mar 2001	WO
WO 2004056275	Jul 2001	WO
WO 0202162	Jan 2002	WO
WO 0211627	Feb 2002	WO
WO 0243616	Jun 2002	WO
WO 02070061	Sep 2002	WO
WO 02094111	Nov 2002	WO
WO 03002006	Jan 2003	WO
WO 03030751	Apr 2003	WO
WO 03051448	Jun 2003	WO
WO 2004028571	Apr 2004	WO
WO 2005000130	Jan 2005	WO
WO 2005027779	Mar 2005	WO
WO 2006021407	Mar 2006	WO
WO 2006031410	Mar 2006	WO
WO 2006107641	Oct 2006	WO
WO 2006135823	Dec 2006	WO
WO 2007054307	May 2007	WO
WO 2007068424	Jun 2007	WO
WO 2008034615	Mar 2008	WO
WO 2008051431	May 2008	WO
WO 2008131116	Oct 2008	WO
WO 2008135823	Nov 2008	WO
WO 2009031338	Mar 2009	WO
WO 2009076482	Jun 2009	WO
WO 2009086482	Jul 2009	WO
WO 2009105710	Aug 2009	WO
WO 2010010545	Jan 2010	WO
WO 2010046897	Apr 2010	WO
WO 2010075565	Jul 2010	WO
WO 2010102307	Sep 2010	WO
WO 2010146581	Dec 2010	WO
WO 2011013556	Feb 2011	WO
WO 2011066961	Jun 2011	WO
WO 2011082319	Jul 2011	WO
WO 2011095352	Aug 2011	WO
WO 2011106426	Sep 2011	WO
WO 2011110316	Sep 2011	WO
WO 2011135556	Nov 2011	WO
WO 2012052982	Apr 2012	WO
WO 2012064726	May 2012	WO
WO 2012081020	Jun 2012	WO
WO 2012120490	Sep 2012	WO
WO 2012110619	Oct 2012	WO
WO 2012156924	Nov 2012	WO
WO 2013016435	Jan 2013	WO
WO 2013072777	May 2013	WO
WO 2013105099	Jul 2013	WO
WO 2013109756	Jul 2013	WO
WO 2013187927	Dec 2013	WO
WO 2014047650	Mar 2014	WO
WO 2014081892	May 2014	WO
WO 2014139845	Sep 2014	WO
WO 2014169266	Oct 2014	WO
WO 2014178198	Nov 2014	WO
WO 2015061365	Apr 2015	WO
WO 2015103547	Jul 2015	WO
WO 2015134625	Sep 2015	WO
WO 2015179324	Nov 2015	WO
WO 2015189354	Dec 2015	WO
WO 2016010995	Jan 2016	WO
WO 2016089451	Jun 2016	WO
2017103686	Jun 2017	WO
WO 2017089424	Jun 2017	WO
WO 2017161204	Sep 2017	WO
WO 2020039082	Feb 2020	WO
WO 2021113302	Jun 2021	WO

Non-Patent Literature Citations (1)

Entry
US 6,348,062 B1, 02/2002, Hopkins (withdrawn)

Related Publications (1)

	Number	Date	Country
	20190365399 A1	Dec 2019	US

Continuations (2)

	Number	Date	Country
Parent	15226389	Aug 2016	US
Child	16544423		US
Parent	13829684	Mar 2013	US
Child	15226389		US

Clot retrieval devices

Information

Patent Number

Date Filed

Date Issued

Inventors

Original Assignees

Examiners

Agents

CPC

Field of Search

CPC

International Classifications

Term Extension

Abstract