Claims
- 1. A compound represented by either of the general formulae (I) and (II): ##STR7## where X and Y separately represent H, lower alkyl (optionally substituted with hydroxy and/or amino functions) containing from 1 to 6 carbon atoms, or phenyl; R represents H, lower alkyl (optionally substituted with hydroxy and/or amino functions), phenyl (optionally substituted with Me, OQ, CONHQ and/or NHCOQ, where Q is lower alkyl optionally substituted with hydroxy and/or amino functions and containing from 1 to 6 carbon atoms) or halogen, and Z.sup.- is Cl.sup.-, Br.sup.-, I.sup.-, ClO.sub.4.sup.-, NO.sub.3.sup.-, HCO.sub.3.sup.- or any other pharmaceutically-acceptable organic or inorganic counterion.
- 2. A compound of formula (II) according to claim 1 where X and Y are Me, R is H and Z.sup.- is ClO4.sup.-.
- 3. A compound of formula (II) according to claim 1 where X and Y are Me, R is Me and Z.sup.- is ClO.sub.4.sup.-.
- 4. A compound of formula (II) according to claim 1 where X and Y are Me, R is Et and Z.sup.- is ClO.sub.4.sup.-.
- 5. A compound of formula (II) according to claim 1 where X and Y are Me, R is Pr and Z.sup.- is ClO.sub.4.sup.-.
- 6. A compound of formula (II) according to claim 1 where X and Y are Me, R is Cl and Z.sup.- is Cl.sup.-.
- 7. A compound of formula (I) according to claim 1 where X and Y are Me, R is H and Z.sup.- is ClO.sub.4.sup.-.
- 8. A compound of formula (I) according to claim 1 where X and Y are Me, R is Me and Z.sup.- is ClO.sub.4.sup.-.
- 9. A compound of formula (I) according to claim 1 where X and Y are Me, R is Et and Z.sup.- is Cl.sup.-.
- 10. A process for the preparation of a compound represented by either of the general formulae (I) and (II) as defined in claim 1, which process comprises deprotonation of a 3-R-2,4-pentanedione with aqueous sodium hydroxide and reaction with the sodium salt of the hexanitrocobaltate complex, Na.sub.3 [Co(NO.sub.2).sub.6 ], isolating the resulting bis-3-R-pentane-2,4-dionato dinitro cobalt (III) anion complex as the sodium salt, mixing a solution of said sodium salt with a solution of either N,N-bis(2-chloroethyl)ethylenediamine or N,N'-bis(2-chloroethyl)ethylenediamine, stirring the mixture at a temperature between 0.degree.-40.degree. C. for the appropriate period, and adding a suitable anion to precipitate the compound of formula (I) or (II).
- 11. A pharmaceutical composition which comprises at least one compound represented by one of the general formulae (I) and (II) as defined in claim 1, and one or more pharmaceutically-acceptable carriers or diluents.
Priority Claims (1)
Number |
Date |
Country |
Kind |
236906 |
Jan 1991 |
NZX |
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Parent Case Info
This is a continuation-in-part of application Ser. No. 08/083,862, filed Jun. 28, 1993, now abandoned, which is a continuation of application Ser. No. 07/825,228, filed Jan. 24, 1992, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4189306 |
Sandy |
Feb 1980 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
825228 |
Jan 1992 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
83862 |
Jun 1993 |
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