Claims
- 1. A substantially purified compound represented by the general formula (III): ##STR7## where R.sub.1 -R.sub.5 separately represent H, lower alkyl (optionally substituted with hydroxy and/or amine functions) containing from 1 to 6 carbon atoms, or CH.sub.2 CH.sub.2 Cl, except that two but not more than two of R.sub.1 -R.sub.5 shall represent CH.sub.2 CH.sub.2 Cl groups in any one molecule; L.sub.1 -L.sub.3 separately represent all possible combinations of Cl.sup.-, NO.sub.2.sup.- and NH.sub.3 monodentate ligands, or represent a combination of one of these monodentate ligands together with an acetylacetonate bidentate ligand, or collectively represent a tridentate ligand selected from iminodiacetato, N-(Q)iminodiacetato where Q is lower alkyl (optionally substituted with hydroxy and/or amine functions) containing from 1 to 6 carbon atoms, glycylglycinato and 2,6-pyridinedicarboxylato; n is 0 or 1, and, when n=1, Z.sup.- represents Cl.sup.-, Br.sup.-, I.sup.-, ClO.sub.4.sup.-, NO.sub.3.sup.-, HCO.sub.3.sup.- or any other pharmaceutically-acceptable organic or inorganic counterion.
- 2. A compound represented by the general formula (III): ##STR8## where R.sub.1 -R.sub.5 separately represent H, lower alkyl (optionally substituted with hydroxy and/or amino functions) containing from 1 to 6 carbon atoms, or CH.sub.2 CH.sub.2 Cl, except that not more than two of R.sub.1 -R.sub.5 shall represent CH.sub.2 CH.sub.2 Cl groups in any one molecule; L.sub.1 -L.sub.3 separately represent all possible combinations of Cl.sup.-, NO.sub.2.sup.- and NH.sub.3 monodentate ligands, or a combination of one of these monodentate ligands together with an acetylacetonate bidentate ligand or may collectively represent a tridentate ligand; n is 0 or 1, and, when n=1, Z.sup.- represents Cl.sup.-, Br.sup.-, I.sup.-, ClO.sub.4.sup.-, NO.sub.3.sup.-, HCO.sub.3.sup.- or any other pharmaceutically-acceptable organic or inorganic counterion; and with the proviso that compound is not selected from the group consisting of [Co(NO.sub.2).sub.3 (Cl-etoldien)], [Co(NO.sub.2).sub.2 --Cl(Cl-etoldien)] and [Co(NO.sub.2).sub.3 (dietoldien)].
- 3. The compound of claim 1, or 2 in which said tridente ligand is selected from the group consisting of iminodiacetato, glycylglycinato, 2,6-pyridinedicarboxylate, and N-(Q) iminodiacetato, where Q is a lower alkyl (optionally substituted with hydroxy and/or amino functions) containing from 1 to 6 carbon atoms.
- 4. A compound of formula (III) according to claim 1, where L.sub.1 -L.sub.3 are NO.sub.2 --, R.sub.1 and R.sub.2 are CH.sub.2 CH.sub.2 Cl, R.sub.3 -R.sub.5 are H, and n=0.
- 5. A process for the preparation of a compound represented by the general formula (III) as defined in claims 1 or 2, which comprises mixing a solution of the sodium salt of the hexanitrocobaltate complex, Na.sub.3 [Co(NO.sub.2).sub.6 ], with a solution of N',N-bis(2-chloroethyl)-diaethylene triamine mustard ligand, stirring the mixture at a temperature between 0.degree.-40.degree. C. for the appropriate period, and, if desired, substituting one or more of the remaining nitro groups with the appropriate ligand.
- 6. A pharmaceutical composition having antitumour activity which comprises:
- a) at least one compound represented by the general formula III as defined in claim 1, and one or more pharmaceutically-acceptable carriers or diluents.
- 7. A method for treating tumours in a patient, which comprises administering to the patient an antitumor effective amount of at least one compound represented by the general formula (III) as defined in claim 1.
- 8. The method of claim 7 in which said tumours are cancers.
Priority Claims (1)
Number |
Date |
Country |
Kind |
236906 |
Jan 1991 |
NZX |
|
Parent Case Info
This is a division of application Ser. No. 08/184,413, filed Jan. 21, 1994, now U.S. Pat. No. 5,348,977, issued Sep. 20, 1994, which, in turn, is a continuation-in-part of application Ser. No. 08/083,862, filed Jun. 28, 1993, which, now abandoned, in turn, is a continuation of Ser. No. 07/825,228, filed Jan. 24, 1992, and now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
2645653 |
Zerweck et al. |
Jul 1953 |
|
4189306 |
Sandy |
Feb 1980 |
|
Non-Patent Literature Citations (1)
Entry |
J. A. Broanhead, "The Reactivity of Hydroxy Groups in Metal Complexes", J. Am. Chem. Soc. 90(16):4480 (1968). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
184413 |
Jan 1994 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
825228 |
Jan 1992 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
83862 |
Jun 1993 |
|