Cocrystallization

Abstract

The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.

Description

FIELD OF THE INVENTION

The present disclosure describes cocrystals comprising active agents, especially active pharmaceutical ingredients (APIs), and methods relating to cocrystals. In particular, novel cocrystals are provided of a salt of an active pharmaceutical ingredient (such as a salt having chloride as the counterion) and a guest that forms a relatively strong interaction with the counterion. Methods are provided for searching for possible solid state phases of a sample and include solidifying the sample as a cocrystal. Methods are also provided for screening a sample for solid state phases and include solidifying the sample as a cocrystal.

BACKGROUND OF THE INVENTION

Cocrystals are crystals that contain two or more non-identical molecules. Examples of cocrystals may be found in the Cambridge Structural Database. Examples of cocrystals may also be found at Etter, Margaret C., and Daniel A. Adsmond (1990) “The use of cocrystallization as a method of studying hydrogen bond preferences of 2-aminopyridine” J. Chem. Soc., Chem. Commun. 1990 589-591, Etter, Margaret C., John C. MacDonald, and Joel Bernstein (1990a) “Graph-set analysis of hydrogen-bond patterns in organic crystals” Acta Crystallogr., Sect. B, Struct. Sci. B46 256-262, Etter, Margaret C., Zofia Urbańczyk-Lipkowska, Mohammad Zia-Ebrahimi, and Thomas W. Panunto (1990b) “Hydrogen bond directed cocrystallization and molecular recognition properties of diarylureas” J. Am. Chem. Soc. 112 8415-8426, which are incorporated herein by reference in their entireties. The following articles are also incorporated herein by reference in their entireties: Carl Henrik Görbotz and Hans-Petter Hersleth, 2000, “On the inclusion of solvent molecules in the crystal structures of organic compounds” Acta Cryst. (2000), B56, 625-534; and V. S. Senthil Kumar, Ashwini Nangia, Amy K. Katz and H. L. Carrell, 2002, “Molecular Complexes of Some Mono- and Dicarboxylic Acids with trans-1,4,-Dithiane-1,4-dioxide” American Chemical Society, Crystal Growth & Design, Vol. 2, No. 4, 2002.

The identification of an optimal composition, formulation, and/or solid state phase is important in the pharmaceutical field, as well as in other fields including nutraceuticals, agricultural chemicals, dyes, explosives, polymer additives, lubricant additives, photographic chemicals, and structural and electronic materials. The new methods described herein may be useful in any of these fields as well as others where solid materials are used.

SUMMARY OF THE INVENTION

As one aspect, novel cocrystals are provided. The novel cocrystals comprise one or more active agents, particularly of the salts of such active agents.

As another aspect, novel cocrystallization methods are provided which have increased probability of successful cocrystallization. A suitable method of cocrystallization may include identifying a crystal comprising a salt of an active agent, wherein the salt comprises the active agent and a negative counterion. One may identify coordination of the negative counterion (for example, its hydrogen bond interactions within that crystal). One may then select a guest to coordinate more strongly with the negative counterion than the coordination within the crystal. Based upon the evaluation of the nonbonded interactions involving one component of an active agent and/or guest, one selects another molecule or molecules or a salt that will coordinate well, or interact strongly with a hydrogen bond acceptor site that has been identified as being involved in a weak hydrogen bond. If the acceptor site has the ability to interact with stronger hydrogen bond donors, and thus form a more energetically favorable interaction, yet it is presently involved in a weak interaction, then the opportunity exists to replace the weak donor with a stronger one. For example, if a strong hydrogen bond acceptor is interacting with a weak hydrogen bond donor in a crystal, a cocrystal could be created by adding a strong hydrogen bond donor molecule to the system which would replace the weak donor and bond to the strong acceptor site in the resulting cocrystal. After the selection of a suitable guest, a solution, melt, or physical mixture comprising the active agent, the counterion, and the guest may be prepared. The solution or melt is subjected to a crystallization process, such as evaporation, cooling, or any of the many well-known processes for forming a crystal from a solution or melt. The physical mixture can be ground to form the cocrystal. A cocrystal is formed comprising the salt of the active agent and the guest.

As another aspect, the present disclosure provides a cocrystallization method that produces a novel type of chloride salt cocrystal structure. The method can be useful for generating beneficial solid chloride salts of APIs in cases where the chloride salt was previously disfavored.

As yet another aspect, novel forms of salts of active pharmaceutical ingredients are provided. For example, the present disclosure provides novel cocrystals of fluoxetine HCl and benzoic acid; fluoxetine HCl and succinic acid; and fluoxetine HCl and fumaric acid. Novel forms or solid state phases of active pharmaceutical ingredients may be prepared for which there are no known polymorphs, solvates or hydrates, or where such polymorphs, solvates or hydrates were disfavored.

As a further aspect, a method of modifying one or more physical properties of a drug formulation or drug composition which comprises an API, the method comprising forming a series of cocrystals of the API with a plurality of guests. The method may further comprise measuring a physical property of the cocrystal and/or adjusting the drug formulation or drug composition.

As yet another aspect, an improved method for screening or selecting the optimal solid state phase for active agents, particularly active pharmaceutical ingredients, and salts thereof, is provided. The screening method comprises crystallizing or attempting to crystallize the free base of the active agent, a chloride salt of the active agent, and optionally other salts of the active agent, and cocrystallizing or attempting to cocrystallize the free base of the active agent, a chloride salt of the active agent, and optionally other salts of the active agent. The method may further comprise evaluating one or more properties of the solid forms, such as one or more physical properties.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1( a) and (b) illustrate a crystal structure of an active pharmaceutical ingredient and a cocrystal structure containing the same API with a guest molecule.

FIGS. 2( a) and (b) are drawings of two-dimensional and three-dimensional models of a cocrystal of fluoxetine HCl and benzoic acid (1:1).

FIGS. 3( a) and (b) are drawings of two-dimensional and three-dimensional models of a cocrystal of fluoxetine HCl and succinic acid (2:1).

FIGS. 4( a) and (b) show a two-dimensional drawing of nabumetone and 2,3-naphthalenediol and a three-dimensional model of a cocrystal of nabumetone and 2,3-naphthalenediol (1:1).

FIG. 5 shows examples of general classes of guests.

DETAILED DESCRIPTION OF THE INVENTION

The present disclosure provides a way of investigating cocrystals and a way of creating new solid state phases in which one or more active agents are cocrystallized with a guest. By cocrystallizing an active agent with a guest such as a pharmaceutically acceptable compound, one can create new solid state phases which may have improved properties over existing solid state phases of that active agent. For example, new drug formulations comprising cocrystals of active pharmaceutical ingredients may have superior properties over existing drug formulations. The active agent and guest will vary depending on the industry. For example, in the pharmaceutical field, the active agent or guest may be an API, and the other component of the cocrystal must be a pharmaceutically acceptable compound. The present techniques are also applicable to active agents from other fields including nutraceuticals, agricultural chemicals, pigments, dyes, explosives, polymer additives, lubricant additives, photographic chemicals, and structural and electronic materials.

Broadly speaking, one aspect relates to the use of undercoordinated counterions to facilitate cocrystallization. While the inventor does not wish to be bound to theory, the inventor believes excellent cocrystals may be formed using hydrochloride salts and similar salts which are strong hydrogen bond acceptors yet contain relatively undercoordinated ions. “Undercoordinated” in this case refers to ions, for example a chloride ion, that are able to form a number of strong hydrogen bonds. An undercoordinated counterion may have hydrogen bonds within a crystal of that salt, but it could form additional hydrogen bonds in a cocrystal and/or form relatively stronger hydrogen bonds in a cocrystal with a guest. An ion is “undercoordinated” when the system is limited in the number of hydrogen bond donors that are available and bonded to the ion. In these cases, the extra hydrogen bond acceptor sites are typically filled by weakly interacting donors such as C—H groups. Chloride ions are strong hydrogen bond acceptors in a crystal structure. In a crystal structure such as fluoxetine hydrochloride, the chloride ion coordinates to the two strong hydrogen bond donors available in the system, and the chloride ion also has three weaker CH—Cl interactions resulting in a pseudo-octahedral coordination environment. There is an opportunity for bonding with these coordination sites, by displacing the weak CH donors that the chloride has recruited to fill its coordination sphere with somewhat stronger hydrogen bond donors from a guest such as benzoic acid, succinic acid, fumaric acid, or another carboxylic acid.

It is useful in forming cocrystals to recognize that relatively weak interactions may be replaced by stronger interactions, even though those stronger interactions may be relatively weak themselves, compared to other interactions. For example, an undercoordinated chloride may have one strong hydrogen bond donor and several weak hydrogen bond donors or two strong hydrogen bond donors and several weak hydrogen bond donors. In a cocrystal, weaker interactions may be replaced by stronger interactions, although those stronger interactions may still be weaker than the strong interactions (charge-assisted hydrogen bonds) present in fluoxetine HCl crystals. The strongest interactions involving chloride ions in crystal structures of organic salts are the charge assisted hydrogen bonds that invariably form between the protonated nitrogen base and the chloride ion. The strongest interactions between neutral molecular groups and the chloride ion involve acids and the chloride ion. Carboxylic acids, for instance, have strong interactions with chloride ions. It can be seen that a combination of carboxylic acids and hydrochloride salts of nitrogen containing bases are especially well suited to cocrystal formation (as demonstrated by the examples included). Furthermore, it can be anticipated that different combinations of these elements could lead to other cocrystals. For example, the active molecule of interest may contain either the neutral carboxylic acid moiety or the protonated nitrogen. The potential exists to cocrystallize an API having a neutral carboxylic acid moiety with a guest that is a hydrochloride salt of a nitrogen-containing organic base.

It is further contemplated that the nature of the protonated nitrogen base will affect the potential for cocrystallization. Numerous strong hydrogen bond donor groups will compete with the carboxylic acid guest for the open acceptor sites on the chloride ion. In order to favor cocrystal formation, the nitrogen base is preferably a tertiary amine because this presents a situation where only one strong charged hydrogen bond donor exists and thus will only occupy one site on the chloride acceptor. Additionally, systems that have only this one tertiary amine and no other strong donors present an especially favorable system for potential cocrystallization. Protonated secondary amines with two N—H donor groups are also favored, although protonated primary amines may also be used. Special consideration must be taken for systems with additional strong hydrogen bond donor and acceptor sites in order to determine the potential for cocrystallization and the optimal guest molecule type for cocrystallization. The potential for cocrystallization involving a carboxylic acid and a hydrochloride salt may be reduced as the number of available strong donors in the system is increased. Additional guidance as to evaluating undercoordination may be found in the inventor's prior work (which is incorporated by reference herein in its entirety), particularly in its discussion of nonbonded motifs: Scott L. Childs, “Nonbonded Interactions In Molecular Crystal Structures”, Emory Univ., USA, available from UMI, Order No. DA3009424 (288 pp.), Dissertation Abstract Int. Ref. B2001, 62(3), 1394. In some circumstances, the undercoordination can be determined by measuring distances, comparing profiles in the Cambridge Structural Database, measuring the pKa of the donors and acceptors, or evaluating the ratio of strong hydrogen bond donors to available acceptors. Other crystal engineering theories may also be used.

The formation of cocrystals is very unpredictable. It is difficult to foresee structural changes as a function of changes in molecular substitution patterns or in molecular geometry. However, the present disclosure provides greater predictability and better probability of success in designing and forming cocrystals.

The present techniques may be employed to generate a wide variety of cocrystals of active agents and guests. For example, the present techniques may be used to generate cocrystals of a salt of an active agent, such as a salt of an active pharmaceutical ingredient, with a neutral guest. Alternatively, a cocrystal of a neutral or zwitterionic active agent (or a salt of an active agent) may be generated with a guest salt, which includes a positive ion and a negative ion of its own. Where the active agent is provided in a salt, it may be positively or negatively charged and have a negative or positive counterion. As an example, for fluoxetine HCl, the active agent fluoxetine is positively charged by virtue of accepting a proton from HCl to form a protonated amine, and chloride is present as a negative counterion. Furthermore, some of the present methods may be employed with a neutral or zwitterionic active agent to form a cocrystal with a neutral guest or ionic guest.

The present techniques provide an opportunity to create a stable solid state phase of a hydrochloride salt of an API that was previously found to have properties that were unsuitable for development. Opportunities for continued development in such a situation have often relied on the fortuitous formation of a stable hydrate or solvate, but the present techniques present the ability to systematically examine alternative formulations of the hydrochloride salt by cocrystallizing the hydrochloride salt of the API with appropriate guest molecules.

Cocrystallization may be an attractive technique for salts of APIs that have been rejected due to problems relating to physical properties. Since cocrystals may have different physical properties than the individual components, APIs with unfavorable physical properties can be cocrystallized with suitable guest molecules and the physical properties of the resulting crystalline solids can be evaluated.

The cocrystals of fluoxetine HCl provide examples of the modification of a physical property (solubility) of an API salt. Cocrystals of fluoxetine HCl:benzoic acid are less soluble and have a lower dissolution rate than crystals of fluoxetine HCl, while cocrystals of fluoxetine HCl:succinic acid are more soluble and have a faster dissolution rate than crystals of fluoxetine HCl.

Other physical properties of APIs or their salts that may be modified by forming a cocrystal include: melting point, density, hygroscopicity, crystal morphology, loading volume, compressibility, and shelf life. Furthermore, other properties such as bioavailability, toxicity, taste, physical stability, chemical stability, production costs, and manufacturing method may be modified by the use of the present cocrystallization techniques.

An active agent can be screened for possible cocrystals where polymorphic forms, hydrates or solvates are especially problematic. A neutral compound that can only be isolated as amorphous material could be cocrystallized. Forming a cocrystal may up-grade the performance of a drug formulation of an active pharmaceutical ingredient by changing physical properties. Some APIs are problematic during wet granulation and compression stages. A bioequivalent cocrystal could rectify this problem.

A cocrystal can be used to isolate or purify a compound during manufacturing. If it is desirable to identify all of the solid state phases of an active pharmaceutical ingredient, then cocrystallization may be particularly desirable.

The present techniques provide new methods of developing and screening active pharmaceutical ingredients. Non-toxic cocrystalline forms of neutral active pharmaceutical ingredients may be prepared, screened, tested, and commercialized. Screening based on cocrystal formation is equivalent in many respects to a salt-screen for neutral APIs. Furthermore, new types of HCl salt structures may be prepared. The properties of hydrochloride salts can be tuned and perfected. New, unique, stable, and marketable phase of hydrochloride salts may be prepared. One can choose whether to make the formulation more soluble or less soluble.

As another aspect, the present techniques may also be used to remove or reduce the water of hydration, and/or to prepare a cocrystal substantially free of water of hydration. A hydrate may be viewed as a cocrystal having water as the guest. Water and guest acids perform a similar role in the stabilization of the crystal structure. In fact, about 28% of the hydrochloride salts of API in the Cambridge Structure Database are hydrates, compared to about 8% of all other organic structures. This indicates an affinity for hydration. The present techniques both capitalize and rectify this affinity, in that an affinity for cocrystallization (as evidence by hydration) is likely indicated, and this affinity for cocrystallization may be employed for the formation of cocrystals with a suitable guest, such as an acid, for example a carboxylic acid. Indeed, in many cocrystals, an acid may have stronger interactions than water molecules and may displace the water of hydration during the formation of the cocrystal. Accordingly, the present techniques provide a method of preparing a cocrystal from a hydrate. A hydrate of a salt is provided, and the hydrate comprises water of hydration. A guest is selected to coordinate with the counterion. Preferably, the guest coordinates more strongly with the counterion than the solvent does. A solution, melt or physical mixture is prepared which comprises the hydrate and the guest. The solution or melt is subjected to a crystallization process, or the physical mixture is subjected to grinding, and a cocrystal comprising the salt of the active agent and the guest is formed, and the salt comprises the active agent and a counterion. Similarly, the present techniques provide a method of preparing a cocrystal from a solvate. A solvate of a salt is provided, and the solvate comprises solvent molecules coordinated with the salt. A guest is selected to coordinate with the counterion. Preferably, the guest coordinates more strongly with the counterion than the solvent does. A solution, melt or physical mixture is prepared comprising the solvate and the guest. The solution or melt is subjected to a crystallization process, or the physical mixture is subjected to grinding, and a cocrystal comprising the salt of the active agent and the guest is formed. The salt comprises the active agent and a counterion.

FIGS. 2( a) and (b) are drawings of two-dimensional and three-dimensional models of a cocrystal of fluoxetine HCl and benzoic acid (1:1). FIG. 2(a) shows a two-dimensional model in which the chloride ion interacts with the hydrogens of the amine group of fluoxetine and of the hydroxyl group of benzoic acid. Through these interactions, which may be characterized as hydrogen bonding, fluoxetine hydrochloride and benzoic acid form a supramolecular structure that may be the basis of a cocrystal. FIG. 2(b) shows a three-dimensional model of the supramolecular organization of fluoxetine hydrochloride and benzoic acid.

FIG. 3( a) and (b) are drawings of two-dimensional and three-dimensional models of a cocrystal of fluoxetine HCl and succinic acid (2:1). FIG. 3(a) shows a two-dimensional model in which the chloride ion interacts with the hydrogens of the ammonium group of fluoxetine and of the hydroxyl group of succinic acid. Through these interactions, which may be characterized as hydrogen bonding, two molecules of fluoxetine hydrochloride and one molecule of succinic acid form a supramolecular structure that may be the basis of a cocrystal. FIG. 3(b) shows a three-dimensional model of the supramolecular organization of the molecules of fluoxetine hydrochloride and succinic acid.

FIGS. 4( a) and (b) show a two-dimensional drawing of nabumetone and 2,3-naphthalenediol and a three-dimensional model of a cocrystal of nabumetone and 2,3-naphthalenediol (1:1).

Active Agent

The active agent is the molecule whose activity is desirable or the object of interest. It is contemplated that one or more active agents may be employed in a cocrystal, according to any of the present techniques. For example, where the active agent is an active pharmaceutical ingredient, the pharmaceutical activity of the active agent is desirable. Other active agents may be nutraceuticals, agricultural chemicals, pigments, dyes, explosives, polymer additives, lubricant additives, photographic chemicals, or structural and electronic materials.

The active agent may be provided as a salt. It is contemplated that one or more salts may be employed in a cocrystal, according to any of the present techniques. The salt may be prepared from the active agent or obtained from a commercial source. Hydrochloride salts of active pharmaceutical ingredients, especially of amine APIs, are especially preferred in the pharmaceutical industry.

In general, it is contemplated that the present techniques will have particularly good results as applied to amine HCl salts as well as other ammonium salts as described in more detail herein. In ammonium acid salts, the active agent has at least one amine moiety which is relatively basic (at least one relatively basic nitrogen), and a salt is formed with an acid that reacts with the amine moiety. Cocrystals may be then formed between the ammonium salts and guests which act as hydrogen-bond donors to the salts. Cocrystals may be formed of chloride salts of APIs, for example buspirone hydrochloride, fluoxetine hydrochloride, and metformin hydrochloride.

The present cocrystals may comprise salts other than chloride salts—the hydrochloride API salts that are listed above are only a sampling of the relevant compounds because the starting material need not be a known hydrochloride. Indeed, many relevant APIs are salts that are not HCl salts because the HCl salt was not believed to be an appropriate material and a different salt was commercialized instead. The present techniques may enable one to employ an HCl salt of an API that is marketed as another type of salt. Alternatively, it may be desirable to employ a salt other than an HCl salt, by replacing the HCl or by forming a salt comprising an active agent that acts as a base with an acid other than HCl. The following acids provide anionic counterions that would be used to replace chlorine. These are relatively strong acids, and include but are not limited to mineral acids, and the carboxylic acid guest is expected to form one or more hydrogen bonds with a hydrogen bond acceptor on the anionic counterion. The list is the conjugate acid that would react with a basic active agent to form a salt:

sulfuric acid

phosphoric acid

hydrobromic acid

nitric acid

pyrophosphoric acid

methanesulfonic acid

thiocyanic acid

naphthalene-2-sulfonic acid

1,5-naphthalenedisulfonic acid

cyclamic acid

p-toluenesulfonic acid

maleic acid

L-aspartic acid

2-hydroxy-ethanesulfonic acid

glycerophosphoric acid

ethanesulfonic acid

hydroiodic acid

The present techniques also extend beyond salts as starting materials and also include many weak bases that may have been marketed as neutral forms because the known salts did not have appropriate properties. These salts could be revisited and attempts could be made to cocrystallize the HCl salt. For example, a drug formulation marketed as a tartrate salt of an API could be reformulated by cocrystallizing the HCl salt of the active molecule with an appropriate guest molecule. Thus, cocrystallization could make a useful HCl cocrystal out of the API that is currently marketed as a tartrate, sulfate, or other salt formulation. For this reason the present disclosure includes APIs that are not HCl salts as starting materials.

Furthermore, the present techniques relate to salts other than chloride salts. It is contemplated that hydrobromide salts and sodium salts of APIs may especially benefit from the present techniques, since they form relatively strong nonbonded interactions. For example, the hydrobromide salts citalopram hydrobromide and galantamine hydrobromide are contemplated for cocrystallization with benzoic acid, succinic acid, and other guests compatible with hydrochloride salts.

The present techniques may be employed to form cocrystals of sodium salts of APIs such as, for example, naproxen sodium, tolmetin sodium, and warfarin sodium. When a sodium salt (or other salt of an API having a positive counterion) is employed, different guests are expected to be suitable for cocrystallization than when a hydrochloride salt (or other anionic salt) of an API is employed.

Anions and Cations

As one aspect, the active agent is provided as a salt. A salt of the active agent is formed. Alternatively or additionally, the guest is provided as a salt or a salt of the guest is formed. The salt may comprise the active agent and a counterion that is either a cation or an anion. Among the preferred cations (including cations as well as compounds that can form cations) are aluminum, ammonium, benzathine, calcium, diethanolamine, diethylamine, dimeglumine, disodium, lithium, lysine, magnesium, meglumine, potassium, sodium, and zinc. Among the preferred anions are acetate, L-aspartate, besylate, bicarbonate, carbonate, D-camsylate, L-camsylate, citrate, edisylate, fumarate, gluconate, hydrobromide/bromide, hydrochloride/chloride, D-lactate, L-lactate, DL-lactate, D,L-malate, L-malate, mesylate, pamoate, phosphate, succinate, sulfate, D-tartrate, L-tartrate, D,L-tartrate, meso-tartrate, benzoate, gluceptate, D-glucuronate, hybenzate, isethionate, malonate, methylsufate, 2-napsylate, nicotinate, nitrate, orotate, stearate, tosylate, acefyllinate, aceturate, aminosalicylate, ascorbate, ascorbate, borate, butyrate, camphorate, camphocarbonate, decanoate, hexanoate, cholate, cypionate, dichloroacetate, edentate, ethyl sulfate, furate, fusidate, galactarate (mucate), galacturonate, gallate, gentisate, glutamate, glutamate, glutarate, glycerophosphate, heptanoate (enanthate), hydroxybenzoate, hippurate, phenylpropionate, iodide, xinafoate, lactobionate, laurate, maleate, mandelate, methanesufonate, myristate, napadisilate, oleate, oxalate, palmitate, picrate, pivalate, propionate, pyrophosphate, salicylate, salicylsulfate, sulfosalicylate, sulfosalicylate, tannate, terephthalate, thiosalicylate, tribrophenate, valerate, valproate, adipate, 4-acetamidobenzoate, camsylate, octanoate, estolate, esylate, glycolate, thiocyanate, and undecylenate.

When a metal cation is employed as a counterion of the active agent, the interaction between guest and cation is not a hydrogen bond but rather is an intermolecular interaction between an electron rich group such as a carbonyl and the metal cation. This interaction is often not as strong as a hydrogen bond, but is still a favorable interaction and thus can contribute to the stabilization of a cocrystal.

The HCl salt of an active pharmaceutical ingredient is especially preferred to create a new type of cocrystal. In this type of solid state phase, one can cocrystallize the HCl salt with a neutral guest molecule. By doing this one can create solid state phases with specific properties. For instance one can make a solid comprising an active pharmaceutical ingredient having greater or lesser intrinsic solubility and/or a faster or slower dissolution rate, depending on the guest compound that is chosen.

Guests

The guest is present in order to form the cocrystal with the active agent. It is contemplated that one or more guests may be employed in a cocrystal, according to any of the present techniques. Accordingly, the guest is not required to have an activity of its own, although it may have some activity that does not overly derogate from the desired activity of the active agent. In some situations, the guest may have the same activity as or an activity complementary to that of the active agent. The guest may be another API. For example, some guests may facilitate the therapeutic effect of an active pharmaceutical ingredient. For pharmaceutical formulations, the guest may be any pharmaceutically acceptable molecule(s) that forms a cocrystal with the API or its salt. The RTECS database is a useful source for toxicology information, and the GRAS list contains about 2500 relevant compounds.

The guest may be neutral (such as benzoic acid and succinic acid in the examples below) or ionic (such as sodium benzoate or sodium succinate). Neutral guests are nonionic guests. Ionic guests are compounds or complexes having ionic bonds. FIG. 5 shows several general classes of guests (organic bases, organic salts, alcohols & aldehydes, amino acids, sugars, ionic inorganics, aliphatic esters & ketones, organic acids, and aromatic esters & ketones).

The guest may be an acid that forms hydrogen bonds with the chloride (or other anion). For example, suitable guests which are acids include (but not are not limited to):

ascorbic acid

glucoheptonic acid

sebacic acid

alginic acid

cyclamic acid

ethane-1,2-disulfonic acid

2-hydroxyethanesulfonic acid

2-oxo-glutaric acid

naphthalene-1,5-disulfonic acid

nicotinic acid

pyroglutamic acid

4-acetamidobenzoic acid

Table 1 sets forth a group of presently preferred guests. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

Table 2 sets forth another group of preferred guests. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

Table 3 sets forth the group comprising molecules believed at present to be suitable guests. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

Ionic guests are salts themselves, and may be formed from bases and acids prior to being used to form cocrystals. For example, the following bases and acids may be reacted to form ionic guests:

Bases

Ammonia

L-Arginine

Benethamine

Benzathine

Betaine

Calcium Hydroxide

Choline

Deanol

Diethanolamine

Di ethyl amine

2-(Diethylamino)ethanol

2-Aminoethanol

Ethylenediamine

N-Methylglucamine

Hydrabamine

1H-Imidazole

Lysine

Magnesium Hydroxide

Morpholine

4-(2-Hydroxyethyl)Morpholine

piperazine

Potassium Hydroxide

Pyrrolidine

1-(2-Hydroxyethyl)Pyrrolidine

Sodium Hydroxide

Triethanolamine

Tromethamine

Zinc Hydroxide

Acids

(+)-L-Tartaric Acid

1,2,2-Trimethyl-1,3-cyclopentanedicarboxylic Acid

10-Undecylenic Acid

1-Hydroxy-2-naphthoic Acid

(+)-Camphor-10-sulfonic Acid

2,5-Dihydroxybenzoic Acid

2-Furancarboxylic Acid

2-Mercaptobenzoic Acid

3-Cyclopentylpropionic Acid

3-Phenylpropionic Acid

4-Aminosalicylic Acid

4-Hydroxybenzoic Acid

Acetic Acid

Adipic Acid

alpha-Hydroxypropionic Acid

Benzenesulfonic Acid

Benzoic Acid

Carbonic Acid

Cholic Acid

Citric Acid

(−)-D-Tartaric Acid

(+)-D-Camphoric Acid

(+)-D-Malic Acid

(+)-L-Malic Acid

2,2-Dichloroacetic Acid

DL-10-Camphorsulfonic Acid

DL-Glutamic Acid

DL-Malic Acid

DL-Tartaric Acid

Dodecylsulfuric Acid

Ethanesulfonic Acid

Ethylenediaminetetraacetic Acid

Ethylsulfuric Acid

Fumaric Acid

Galactaric Acid

Gallic Acid

Gluconic Acid

Glutaric Acid

Glycolic Acid

Hippuric Acid

Hydriodic Acid

Hydrobromic Acid

Hydrochloric Acid

(−)-L-Apple Acid

(+)-L-Lactic Acid

(+)-L-Tartaric Acid

D,L-Lactic Acid

Lactobionic Acid

L-Aspartic Acid

Lauric Acid

L-Glutamic Acid

Maleic Acid

(−)-L-Malic Acid

Malonic Acid

D,L-Mandelic Acid

Methanesulfonic Acid

Naphthalene-2-sulfonic acid

n-Butyric Acid

n-Decanoic Acid

n-Hexanoic Acid

Nitric acid

n-Tetradecanoic Acid

Octanoic Acid

Oleic Acid

Orotic Acid

Orthoboric Acid

Oxalic Acid

4-Acetamidobenzoic Acid

Palmitic Acid

Pamoic Acid

Phosphoric Acid

Picric Acid

Pivalic Acid

Propionic Acid

p-Toluenesulfonic Acid

Pyrophosphoric Acid

Salicylic Acid

Stearic Acid

Succinic Acid

Sulfosalicylic Acid

Sulfuric Acid

Terephthalic Acid

Thiocyanic Acid

Valeric Acid

Valproic Acid

Typically, suitable guests will have complementary ability to noncovalently bond to the active agent or its salt, for example the ability to form hydrogen bonds with the active agent or its salt. Suitable guests for active agents having negative counterions include, but are not limited to, compounds having alcohol, ketone, ester, and/or carboxylic acid functionalities. Suitable guests may include organic acids, organic bases, organic salts, alcohols, aldehydes, amino acids, sugars, ionic inorganic compounds, aliphatic esters and ketones, and aromatic esters and ketones.

Among the presently preferred neutral guests are those which are not liquids at room temperature. Also among the presently preferred neutral guests are carboxylic acids having at least three carbon atoms, alternatively at least four carbon atoms, and which do not form solvates. For example, if the following acids were combined with active agents, the combination would more properly be considered a solvate than a cocrystal: acetic acid, propionic acid, and butyric acid. However, in certain embodiments of the present invention (for example, in certain cocrystals, cocrystallization methods, and screening methods), the use of solvents and solvates may still be desirable, and the use of solvents and solvates is not excluded from the scope of any cocrystal or method except where explicitly stated.

Detection of Cocrystals

Cocrystals may be detected by x-ray diffraction analysis or other suitable techniques. The observation of physical properties of a solid (particularly its melting point) which differ from the physical properties of the starting materials and the polymorphs and/or solvates and/or hydrates of the starting materials, is an indicator that a cocrystal has been formed.

A method of crystal engineering is described. An active pharmaceutical ingredient such as fluoxetine hydrochloride is recognized as possessing a strong hydrogen bond acceptor. The API is screened against a library of strong hydrogen bond donors or other possible guest compounds. Such a library is selected and ordered based upon nontoxicity, physical property, and the availability and geometric arrangement of hydrogen bond donors that are complementary to the API.

The results from a cocrystal screen of fluoxetine hydrochloride demonstrate a new class of cocrystal that is broadly applicable to a wide variety of hydrochloride salts of APIs. This new approach is a general method that allows creation of cocrystals starting with the hydrochloride salt of the API. Starting with the hydrochloride retains the advantages of the salt, yet one is still able to use the cocrystal method to alter the physical properties of the resulting solid by adding guest molecules.

EXAMPLE 1

Cocrystallization of Fluoxetine HCl and Benzoic Acid

Cocrystals of fluoxetine HCl: benzoic acid were formed using the following procedures. In one preparation, a 505 mg sample of fluoxetine HCl and 178 mg of benzoic acid were dissolved with heating in 5 mL of acetonitrile. The solution was allowed to crystallize in a small crystallization dish. Well-formed crystalline material formed within 7 minutes. This material was isolated on filter paper and dried in the air to yield 546 (80%) of fluoxetine HCl:benzoic acid (1:1) cocrystal.

In another preparation, a 5.00 g sample of fluoxetine HCl and 1.76 g of benzoic acid were dissolved in 50 mL of acetonitrile with heating. The solution was allowed to crystallize in a large evaporating dish. The resulting solid was isolated on filter paper and dried in the air to yield 5.40 g (92%) of fluoxetine HCl:benzoic acid (1:1) cocrystal.

The cocrystal had a relatively slow dissolution rate and lower water solubility. The measured melting point was 134° C.+/−2° C. for the cocrystal. The cocrystal is expected to have a good toxicology profile, since benzoic acid is known to be safe and appears on the GRAS list from the U.S. Food and Drug Administration.

The resulting cocrystal is a ternary system comprising the protonated API base, the chloride ion, and the neutral guest molecule.

The present inventor believes there are no known solvates or hydrates of fluoxetine hydrochloride. Thus, the formation of a cocrystal of fluoxetine hydrochloride constitutes a surprising achievement and provides a unique composition.

EXAMPLE 2

Cocrystallization of Fluoxetine HCl and Succinic Acid

Cocrystals of fluoxetine HCl and succinic acid were prepared as follows. In one preparation, a 458 mg sample of fluoxetine HCl was dissolved in 8 mL of acetonitrile by heating the solution gently. A 78 mg sample of succinic acid was added to the warm solution and dissolved. The solution was allowed to evaporate rapidly in a crystallization dish. Well-formed crystals as blocks formed as the solvent evaporated over 8 minutes. The product was collected on filter paper and dried to yield 401 mg of fluoxetine HCl:succinic acid (2:1) cocrystal (75% yield).

In another preparation, a 5.00 g sample of fluoxetine HCl and 0.85 g of succinic acid were dissolved in acetonitrile with heating. The solution was allowed to crystallize in an open evaporating dish over a 15 minute period. The solid material was isolated on filter paper and dried to yield 5.40 g (92% yield) of fluoxetine HCl:succinic acid (2:1) cocrystal.

The measured melting points were 158° C. for fluoxetine HCl, 184° C. for succinic acid, and 137° C. for the cocrystal. The cocrystal is expected to have a good toxicology profile, since succinic acid is known to be safe and appears on the Generally Recognized As Safe (!“GRAS”) list from the U.S. Food and Drug Administration.

EXAMPLE 3

Cocrystallization of Nabumetone and 2,3-naphthalenediol

As a demonstrative example, a cocrystal comprising a neutral API is described in this example. Cocrystals of nabumetone (a neutral API) and 2,3-naphthalenediol were prepared as follows. A 4.01 g sample of 2,3-naphthalenediol and 5.7 g of nabumetone were dissolved in 50 mL of nitromethane with heating. A solid was formed as the solution cooled and was allowed to stand overnight. The solid was filtered from the remaining solvent and dried in the air to yield 6.61 g (68%) of nabumetone:2,3-naphthalenediol (1:1) cocrystal.

The resulting cocrystal had a 1:1 molar ratio of nabumetone to 2,3-naphthalienediol. The measured melting points were 80° C. for nabumetone, 162° C. for 2,3-naphthalienediol, and 98° C. for the cocrystal. The cocrystal is expected to have a relatively poor toxicology profile. However, this example demonstrates one basis for the selection of guest molecules: molecular structural similarities. In this case the molecular recognition of the naphthalene moieties of the API and the guest contribute to the stability of the cocrystal. In addition, the stronger alcohol to ketone hydrogen bonds formed by the cocrystal contribute to the stability of the cocrystal. The only hydrogen bond donors available in the API crystal structure are weak C—H groups. The stronger hydrogen bond donors on the guest molecule are able to form stronger intermolecular interaction between the API and guest, compared to the interactions between molecules of the API.

EXAMPLE 4

Crystal Structure Analysis of fluoxetine HCl:benzoic Acid Cocrystal (1:1)

A suitable cocrystal of fluoxetine HCl:benzoic acid (1:1) was coated with Paratone N oil, suspended in a small fiber loop and placed in a cooled nitrogen gas stream at 100 K on a Bruker D8 SMART APEX CCD sealed tube diffractometer with graphite monochromated MoK_α (0.71073Å) radiation. Data were measured using a series of combinations of phi and omega scans with 10 second frame exposures and 0.3° frame widths. Data collection, indexing and initial cell refinements were all carried out using SMART software (SMART Version 5.624, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Frame integration and final cell refinements were done using SAINT software (SAINT Version 6.02, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). The final cell parameters were determined from least-squares refinement on 5435 reflections. The SADABS program was used to carry out absorption corrections (SADABS Version 2.03, 2001, George Sheldrick, University of Göttingen).

The structure was solved using Direct methods and difference Fourier techniques (SHELXTL V5.10, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Hydrogen atoms were placed their expected chemical positions using the HFIX command and were included in the final cycles of least squares with isotropic U_ij's related to the atom's ridden upon. The C—H distances were fixed at 0.93 Å (aromatic and amide), 0.98 Å (methine), 0.97 Å (methylene), or 0.96 Å (methyl). All non-hydrogen atoms were refined anisotropically. Scattering factors and anomalous dispersion corrections are taken from A. J. C. Wilson (ed),

International Tables for X-ray Crystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222) the International Tables for X-ray Crystallography. Structure solution, refinement, graphics and generation of publication materials were performed by using SHELXTL, V5.10 software. Additional details of data collection and structure refinement are given in Table 4 which follows.

EXAMPLE 5

Crystal Structure Analysis of fluoxetine HCl:succinic Acid Cocrystal (2:1)

A suitable cocrystal of fluoxetine HCl-succinic acid (2:1) was coated with Paratone N oil, suspended in a small fiber loop and placed in a cooled nitrogen gas stream at 100 K on a Bruker D8 SMART APEX CCD sealed tube diffractometer with graphite monochromated MoK_α (0.71073Å) radiation. Data were measured using a series of combinations of phi and omega scans with 10 second frame exposures and 0.3° frame widths. Data collection, indexing and initial cell refinements were all carried out using SMART software (SMART Version 5.624, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Frame integration and final cell refinements were done using SAINT software (SAINT Version 6.02, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). The final cell parameters were determined from least-squares refinement on 5435 reflections. The SADABS program was used to carry out absorption corrections (SADABS Version 2.03, 2001, George Sheldrick, University of Göttingen).

The structure was solved using Direct methods and difference Fourier techniques (SHELXTL V5.10, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Hydrogen atoms were placed their expected chemical positions using the HFIX command and were included in the final cycles of least squares with isotropic U_ij's related to the atom's ridden upon. The C—H distances were fixed at 0.93 Å (aromatic and amide), 0.98 Å (methine), 0.97 Å (methylene), or 0.96 Å (methyl). All non-hydrogen atoms were refined anisotropically. Scattering factors and anomalous dispersion corrections are taken from A. J. C. Wilson (ed), International Tables for X-ray Crystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222). Structure solution, refinement, graphics and generation of publication materials were performed by using SHELXTL, V5.10 software. Additional details of data collection and structure refinement are given in Table 5 which follows.

EXAMPLE 6

Crystal Structure Analysis of Nabumetone: 2,3-naphthalenediol Cocrystal (1:1)

A suitable cocrystal of nabumetone:2,3-naphthalenediol (1:1) was coated with Paratone N oil, suspended in a small fiber loop and placed in a cooled nitrogen gas stream at 100 K on a Bruker D8 SMART 1000 CCD sealed tube diffractometer with graphite monochromated CuK_α (1.54178 Å) radiation. Data were measured using a series of combinations of phi and omega scans with 10 second frame exposures and 0.3° frame widths. Data collection, indexing and initial cell refinements were all carried out using SMART software (SMART Version 5.55, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Frame integration and final cell refinements were done using SAINT software (SAINT Version 6.02, 1999, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). The final cell parameters were determined from least-squares refinement on 2869 reflections.

The structure was solved using Direct methods and difference Fourier techniques (SHELXTL V5.10, 1997, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Hydrogen atoms were placed their expected chemical positions using the HFIX command and were included in the final cycle's of least squares with isotropic U_ij's related to the atom's ridden upon. The C—H distances were fixed at 0.93 Å (aromatic and amide), 0.98 Å (methine), 0.97 Å (methylene), or 0.96 Å (methyl). All non-hydrogen atoms were refined anisotropically. Scattering factors and anomalous dispersion corrections are taken from A. J. C. Wilson (ed), International Tables for X-ray Crystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222). Structure solution, refinement, graphics and generation of publication materials were performed by using SHELXTL, V5.10 software. Additional details of data collection and structure refinement are given in Table 6 which follows.

EXAMPLE 7

Cocrystals of Active Agent Salts and Guests

The experiments of Examples 1 and 2 are repeated, using conditions similar to those of those previous Examples, with each possible combination of the salts of active agents and guests identified earlier in this disclosure. Cocrystals are formed which have utility according to the known activity of the active agent.

EXAMPLE 8

Cocrystals of Active Agents and Guest Salts

The experiments of Example 3 are repeated, using conditions similar to those of those previous Examples, with each possible combination of the neutral or zwitterionic active agents and guest salts identified earlier in this disclosure. Cocrystals are formed which have utility according to the known activity of the active agent.

EXAMPLE 9

Cocrystallization of Fluoxetine HCl and Fumaric Acid

Cocrystals of fluoxetine HCl and succinic acid were prepared as follows. A 6.00 g sample of fluoxetine HCl and 1.01 g of fumaric acid were dissolved in 20 mL of ethanol with heating. The solution was filtered through a 0.2 μm nylon filter, concentrated to a volume of 8 mL, and cooled in an ice bath for 6 hours. The solid material was isolated on filter paper and allowed to dry in the air to give 5.74 g (82% yield) of fluoxetine HCl:fumaric acid (2:1) cocrystal. The measured melting points were 158° C. for fluoxetine HCl, >300° C. (decomposes) for fumaric acid, and 164° C. for the cocrystal. The cocrystal is expected to have a good toxicology profile, since fumaric acid is known to be safe and appears on the Generally Recognized As Safe (“GRAS”) list from the U.S. Food and Drug Administration.

EXAMPLE 10

Crystal Structure Analysis of fluoxetine HCl:fumaric Acid Cocrystal (2:1)

A suitable cocrystal of fluoxetine HCl and fumaric acid was coated with Paratone N oil, suspended in a small fiber loop and placed in a cooled nitrogen gas stream at 100 K on a Bruker D8 SMART 1000 CCD sealed tube diffractometer with graphite monochromated CuK_α (1.54178 Å) radiation. Data were measured using a series of combinations of phi and omega scans with 10 second frame exposures and 0.3° frame widths. Data collection, indexing and initial cell refinements were all carried out using SMART software (SMART Version 5.55, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Frame integration and final cell refinements were done using SAINT software (SAINT Version 6.02, 1999, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). The final cell parameters were determined from least-squares refinement on 5625 reflections.

The structure was solved using Direct methods and difference Fourier techniques (SHELXTL V5.10, 1997, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). All the hydrogen atoms were located from difference Fouriers and included in the final cycles of least squares with isotropic U_ij's. All non-hydrogen atoms were refined anisotropically. Scattering factors and anomalous dispersion corrections are taken from A. J. C. Wilson (ed), International Tables for X-ray Crystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222). Structure solution, refinement, graphics and generation of publication materials were performed by using SHELXTL, V5.10 software. Additional details of data collection and structure refinement are given in Table G which follows.

All patents, test procedures, and other documents cited herein, including priority documents, are fully incorporated by reference to the extent such disclosure is not inconsistent with this invention and for all jurisdictions in which such incorporation is permitted.

While the present invention has been described and illustrated by reference to particular embodiments, it will be appreciated by those of ordinary skill in the art that the invention lends itself to many different variations not illustrated herein. For these reasons, then, reference should be made solely to the appended claims for purposes of determining the true scope of the present invention.

Although the appendant claims have single appendencies in accordance with U.S. patent practice, each of the features in any of the appendant claims can be combined with each of the features of other appendant claims or the main claim.

TABLE 1
10-camphorsulfonic acid
10-undecylenic acid
1-hydroxy-2-naphthoic acid
2,4-dihydroxybenzoic acid
2,5-dihydroxybenzoic acid
2-aminopropionic acid
2-ethylbutyrinc acid
2-furancarboxylic acid
2-mercaptobenzoic acid
3-methylbutanoic acid
3-phenylpropionic acid
4-aminobenzoic acid
4-aminosalicylic acid
4-hydroxybenzoic acid
adipic acid
alginic acid
anisic acid
arginine
ascorbic acid
asparagine
aspartic acid
aspirin
benzenesulfonic acid
benzoic acid
4-acetamidobenzoic acid
beta-alanine
camphoric acid
camphorsulfonic acid
carbonic acid
cholic acid
cinnamic acid
citric acid
cyclamic acid
cyclohexanecarboxylic acid
cyclohexylacetic acid
cysteine
diphenylacetic acid
dodecylsulfonic acid
ethane-1,2-disulfonic acid
ethanesulfonic acid
ethanesulfonic acid, 2-hydroxy
ethylenediaminetetraacetic acid
ethylsulfuric acid
fumaric acid
galactaric acid
gallic acid
gentisic acid
glucoheptonic acid
gluconic acid
glutamic Acid
glutamine
glutaric acid
glutaric acid, 2-oxo-
glycine
glycolic acid
hippuric acid
histidine
hydroxyproline
isoleucine
lactobionic acid
lauric acid
leucine
levulinic acid
lysine
maleic acid
malic acid
malonic acid
mandelic acid
m-methoxybenzoic acid
naphthalene-1,5-disulfonic acid
naphthalene-2-sulfonic acid
n-decanoic acid
niacin
nicotinic acid
n-tetradecanoic acid
oleic acid
o-methylbenzoic acid
orotic acid
orthoboric acid
o-toluic acid
p-acetamidobenzoic acid
palmitic acid
pamoic acid
phenoxyacetic acid
phenylacetic acid
phenylalanine
picric acid
pivalic acid
proline
p-toluenesulfonic acid
pyroglutamic acid
pyruvic acid
salicylic acid
sebacic acid
serine
sorbic acid
stearic acid
succinic acid
sulfosalicylic acid
tartaric acid
terephthalic acid
thiocyanic acid
threonine
tiglic acid
tryptophan
tyrosine
valeric acid
valine

TABLE 2
Name                             CAS #
Potassium bicarbonate            298-14-6
Potassium carbonate              584-08-7
Potassium chloride               7447-40-7
Potassium hydroxide              1310-58-3
Potassium metabisulfite          16731-55-8
Potassium nitrate                7757-79-1
Potassium nitrite                7758-09-0
Potassium permanganate           7722-64-7
Potassium persulfate             7727-21-1
Potassium phosphate, dibasic     2139900
Potassium Phosphate Monobasic    7778-77-0
potassium phosphate, tribasic,   7778-53-2
n-hydrate
Potassium sulfate                7778-80-5
Sodium bicarbonate               144-55-8
Sodium bisulfite                 7631-90-5
Sodium borohydride               16940-66-2
Sodium carbonate                 497-19-8
Sodium Carbonate Monohydrate     1486118
Sodium chloride                  7647-14-5
Sodium dithionite                7775-14-6
Sodium fluoride                  7681-49-4
Sodium hexametaphosphate         10124-56-8
Sodium hydroxide                 1310-73-2
Sodium hypochlorite              7681-52-9
Sodium Metabisulfite             7681-57-4
Disodium metasilicate            6834-92-0
sodium monophosphate             7681-53-0
Sodium nitrate                   7631-99-4
Sodium nitrite                   7632-00-0
sodium hydrogen phosphate        7558-79-4
Sodium Phosphate Monobasic       7558-80-7
Sodium Pyrophosphate             7722-88-5
Sodium silicate                  1344-09-8
Sodium Sulfate Decahydrate       7727-73-3
Sodium sulfite                   7757-83-7
Sodium Thiosulfate               10102-17-7
Pentahydrate
Calcium acetate                  5743-26-0
Calcium Carbonate                471-34-1
Calcium Chloride Dihydrate       10035-04-8
Calcium gluconate                299-28-5
Calcium hydroxide                1305-62-0
Calcium oxide                    1305-78-8
Calcium phosphate, dibasic       7757-93-9
Calcium Phosphate Monobasic      7758-23-8
Calcium sulfate                  7778-18-9
Magnesium hydroxide              1309-42-8
Magnesium Sulfate Heptahydrate   10034-99-8
Aluminum                         7429-90-5
Aluminum ammonium sulfate        7784-26-1
Aluminum chloride                7446-70-0
Aluminum hydroxide               21645-51-2
Aluminum potassium sulfate,      7784-24-9
dodecahydrate
Orthoboric acid                  10043-35-3
formaldehyde                     50-00-0
DL-Isoleucine                    443-79-8
(2S,7S)-(−)-Cystine              56-89-3
DL-Alanine                       302-72-7
beta-Alanine                     107-95-9
(S)-(+)-Arginine                 74-79-3
(S)-(−)-Cysteine                 52-90-4
DL-Glutamic acid                 617-65-2
Glycine                          56-40-6
(S)-(−)-Histidine                71-00-1
(S)-(+)-Lysine                   56-87-1
DL-Methionine                    59-51-8
DL-Phenylalanine                 150-30-1
(S)-(−)-Phenylalanine            63-91-2
D-(+)-Proline                    344-25-2
(S)-(−)-Tryptophan               73-22-3
(S)-(−)-Tyrosine                 60-18-4
Carvone                          99-49-0
Citral                           5392-40-5
Ethyl butyrate                   105-54-4
Isobutyl propionate              540-42-1
Methyl butyrate                  623-42-7
n-Propyl acetate                 109-60-4
Isobutyl formate                 542-55-2
Benzyl acetate                   140-11-4
6-Methyl-5-hepten-2-one          110-93-0
Butyl acetate                    123-86-4
Ethyl acetoacetate               141-97-9
Isopentyl Acetate                123-92-2
Cinnamaldehyde                   104-55-2
Methyl benzoate                  93-58-3
Butyl sulfide                    544-40-1
Ethyl benzoate                   93-89-0
2,4-Hexadienoic acid,            24634-61-5
potassium salt, (E,E)-
Potassium bitartrate             868-14-4
Lauric acid                      143-07-7
Benzyl benzoate                  120-51-4
Picric acid                      88-89-1
Benzoyl peroxide                 94-36-0
Palmitic acid                    57-10-3
Dibutyl phthalate                84-74-2
Stearic acid                     57-11-4
Succinic anhydride               108-30-5
Diethylenetriamine               111-40-0
Diethanolamine                   111-42-2
Benzaldehyde                     100-52-7
Phenethylamine                   64-04-0
Salicylylaldehyde                90-02-8
Sodium benzoate                  532-32-1
Cinnamic acid                    621-82-9
Triethanolamine                  102-71-6
L-(+)-Tartaric Acid              87-69-4
Eugenol                          97-53-0
D-mannitol                       69-65-8
Butyl paraben                    94-26-8
Benzoin                          119-53-9
Diethyl phthalate                84-66-2
Oleic acid                       112-80-1
Sodium lactate                   72-17-3
Indole                           120-72-9
ethyl lactate                    97-64-3
quinoline                        91-22-5
Thymol                           89-83-8
Methyl anthranilate              134-20-3
Methyl salicylate                119-36-8
Diethyl malonate                 105-53-3
Citric acid                      77-92-9
Sodium dodecyl sulfate           151-21-3
Morpholine                       110-91-8
Furfural                         98-01-1
Niacin                           59-67-6
Choline chloride                 67-48-1
L-Menthol                        2216-51-5
Meso-inositol                    87-89-8
ethylenediaminetetraacetic       60-00-4
acid
EDTA, calcium derivative,        62-33-9
disodium salt
Calcium pantothenate             137-08-6
Riboflavin                       83-88-5
Zinc carbonate                   3486-35-9
Amyl alcohol                     71-41-0
Mineral oil                      8012-95-1
Triton(R) X-100                  9002-93-1
Acetaldehyde                     75-07-0
Acetic Acid                      64-19-7
Acetone                          67-64-1
Acetophenone                     98-86-2
4-Aminobenzoic acid              150-13-0
Anisole                          100-66-3
Vitamin C                        50-81-7
Benzoic Acid                     65-85-0
Biphenyl                         92-52-4
2-Methyl-1-propanol              78-83-1
n-Butanol                        71-36-3
n-Butylamine                     109-73-9
ethyl acetate                    141-78-6
Caffeine                         58-08-2
Chloroacetic Acid                79-11-8
Dichloroacetic Acid              79-43-6
Diethylamine                     109-89-7
Ethanol Amine                    141-43-5
n-Butyric Acid                   107-92-6
Ethylenediamine                  107-15-3
Formic acid                      64-18-6
n-Hexanol                        111-27-3
Methanol                         67-56-1
Methyl Acetate                   79-20-9
Methyl 4-hydroxybenzoate         99-76-3
m-Cresol                         108-39-4
p-Cresol                         106-44-5
Phenol                           108-95-2
n-Propanol                       71-23-8
Propionic Acid                   79-09-4
Salicylic acid                   69-72-7
Sucrose                          57-50-1
Vanillin                         121-33-5
Vitamin E                        59-02-9
Potassium citrate, monohydrate   1534146
p-toluenesulfonic acid           6192-52-5
monohydrate
D-(+)-Maltose                    69-79-4
Tetrasodium                      64-02-8
ethylenediaminetetraacetate
Saccharin sodium                 128-44-9
Sodium Acetate Trihydrate        6131-90-4
Quinine sulfate, dihydrate       6119-70-6
Sulfosalicylic acid, dihydrate   5965-83-3
L-(+)-Arginine                   1119-34-2
monohydrochloride
Procaine hydrochloride           51-05-8
Pyridoxine Hydrochloride         58-56-0
Thiamine hydrochloride           67-03-8
Propionaldehyde                  123-38-6
Urea                             57-13-6
2-Propanol                       67-63-0
Pyrrole                          109-97-7
Sodium formate                   141-53-7
Pyrrolidine                      123-75-1
Methyl ethyl ketone              78-93-3
Ethyl formate                    109-94-4
Propylene glycol                 57-55-6
Thiourea                         62-56-6
Ammonium acetate                 631-61-8
Benzene                          71-43-2
Sodium acetate                   127-09-3
Cyclopentanone                   120-92-3
Cyclohexane                      110-82-7
piperidine                       110-89-4
2-Pentanone                      107-87-9
hexane                           110-54-3
Isoamyl Alcohol                  123-51-3
Lactic acid                      50-21-5
2-Ethoxyethanol                  110-80-5
Propionic acid, sodium salt      137-40-6
Potassium acetate                127-08-2
cyclohexyl amine                 108-91-8
methyl methacrylate              80-62-6
methyl isobutyl ketone           108-10-1
Acetic anhydride                 108-24-7
Isopropyl Acetate                108-21-4
2,2′-Oxybisethanol               111-46-6
Benzyl alcohol                   100-51-6
Resorcinol                       108-46-3
2-Butoxy ethanol                 111-76-2
Cumene                           98-82-8
2-Amino-2-(hydroxymethyl)-1,3-   77-86-1
propanediol
Phenethyl alcohol                60-12-8
2-Ethyl-1-hexanol                104-76-7
2-Octanol                        123-96-6
2-(2-Ethoxyethoxy) ethanol       111-90-0
2,6-Dimethyl-4-heptanone         108-83-8
Benzophenone                     119-61-9
D-(−)-Fructose                   57-48-7
D-Glucose                        50-99-7
D-Ribose                         50-69-1
D-(+)-Xylose                     58-86-6
Pectin sugar                     5328-37-0
D-(+)-Lactose                    63-42-3
Camphene                         79-92-5
Isoquinoline                     119-65-3
2,4-Dimethylphenol               105-67-9
2,5-Dimethylphenol               95-87-4
2,6-Dimethylphenol               576-26-1
Methanesulfonic Acid             75-75-2
o-Methoxybenzoic Acid            579-75-9
Saccharin                        81-07-2
Thiazole                         288-47-1
Trifluoromethanesulfonic Acid    1493-13-6
Trimethylamine                   75-50-3
Coumarin                         91-64-5
Dimethylamine                    124-40-3
Ethyl Alcohol                    64-17-5
Butyl benzyl phthalate           85-68-7
2,6-dimethylpyrazine             108-50-9
taurocholic acid                 81-24-3
geraniol                         106-24-1
linalool                         78-70-6
ethyl isovalerate                108-64-5
ethyl 2-methylbutyrate           7452-79-1
1-octen-3-ol                     3391-86-4
ethyl 2-trans-4-cis-             3025-30-7
decadienoate
Dihydromyrcenol                  18479-58-8
citronellal                      106-23-0
linalyl acetate                  115-95-7
8-mercapto-p-menthan-3-one       38462-22-5
Ammonium citrate                 3012-65-5
Ammonium bicarbonate             1066-33-7
Ammonium chloride                12125-02-9
Ammonium hydroxide               1336-21-6
Ammonium persulfate              7727-54-0
Ammonium phosphate, dibasic      7783-28-0
Ammonium Phosphate Monobasic     7722-76-1
Ammonium sulfate                 7783-20-2
Ammonium sulfide                 12135-76-1
Hydrazine                        302-01-2
Nitric acid                      7697-37-2
phosphoric acid                  7664-38-2
Phosphorus oxychloride           10025-87-3
Hydriodic acid                   10034-85-2
Hydrobromic acid                 10035-10-6
Hydrochloric acid                7647-01-0
hydrogen peroxide                7722-84-1
Periodic Acid                    10450-60-9
Sulfamic acid                    5329-14-6
Sulfuric acid                    7664-93-9
Sulfurous acid                   7782-99-2
Dexpanthenol                     81-13-0
4-oxoisophorone                  1125-21-9
Copper (II) sulfate              7758-98-7
ferric chloride                  7705-08-0
Ferric oxide                     1309-37-1
ferric sulfate                   10028-22-5
Iron (II) Sulfate Heptahydrate   7782-63-0
Iron                             7439-89-6
Manganese (II) Sulfate           10034-96-5
Monohydrate
Nickel                           7440-02-0
Titanium dioxide                 13463-67-7
Zinc chloride                    7646-85-7
Zinc oxide                       1314-13-2
1,1′-Azobisformamide             123-77-3
1,3-Butanediol                   107-88-0
1-Methylnaphthalene              90-12-0
2,6-Di-tert-Butyl-p-Cresol       128-37-0
2,6-Dimethylpyridine             108-48-5
Disodium                         138-93-2
cyanodithioimidocarbonate
3-Methyl-2-Cyclopentene-2-ol-one 80-71-7
6-Methylcoumarin                 92-48-8
acetoin                          513-86-0
alpha-Phellandrene               99-83-2
alpha-Terpinene                  99-86-5
Benzenesulfonic Acid             98-11-3
Benzothiazole                    95-16-9
borates, tetrasodium salts       1330-43-4
Butyl butyrate                   109-21-7
Butyl Mercaptan                  109-79-5
Butyraldehyde                    123-72-8
Capsaicin                        404-86-4
Chloromethyl Methyl Ether        107-30-2
Cymene                           99-87-6
Diallyl Disulfide                2179-57-9
Diethylaminoethanol              100-37-8
dimethyldisulfide                624-92-0
Dimethyl Succinate               106-65-0
Dimethyl Sulfate                 77-78-1
Dimethyl Sulfide                 75-18-3
Dipropyl Disulfide               629-19-6
Dipropyl Ketone                  123-19-3
Ethyl Acrylate                   140-88-5
Ethyl Butyl Ketone               106-35-4
Ethyl Propionate                 105-37-3
Furfuryl Alcohol                 98-00-0
gamma-Butyrolactone              96-48-0
Glutaraldehyde                   111-30-8
glycerin                         56-81-5
Glycolic Acid                    79-14-1
Isobutyl Acetate                 110-19-0
Isobutyl Isobutyrate             97-85-8
Isobutyraldehyde                 78-84-2
Isoheptanol                      543-49-7
Isophorone                       78-59-1
Isopropyl Mercaptan              75-33-2
Methyl isobutenyl ketone         141-79-7
Methyl n-amyl ketone             110-43-0
methyl acrylate                  96-33-3
Methyl Isobutyrate               547-63-7
Methyl Mercaptan                 74-93-1
N,N-Dimethylethanolamine         108-01-0
n-Butyl Lactate                  138-22-7
n-Hexyl Acetate                  142-92-7
n-Valeraldehyde                  110-62-3
Nitrous Oxide                    10024-97-2
p-Anisaldehyde                   123-11-5
2-Methylcyclohexanone            583-60-8
Octanoic Acid                    124-07-2
Oxalic Acid                      144-62-7
Phenyl ether                     101-84-8
Phenylmercaptan                  108-98-5
Propargyl Alcohol                107-19-7
Propyl paraben                   94-13-3
sec-Butyl Alcohol                78-92-2
Sodium Gluconate                 527-07-1
Sodium Tripolyphosphate          7758-29-4
Tetrahydro-2-furanmethanol       97-99-4
Valeric Acid                     109-52-4
3,4-xylenol                      95-65-8
3-hexanol                        623-37-0
3-methyl-1-pentanol              589-35-5
1,1-diethoxyethane               105-57-7
Aluminum Sulfate                 10043-01-3
ammonium sulfite                 10196-04-0
amyl butyrate                    540-18-1
borneol                          507-70-0
butyl formate                    592-84-7
calcium peroxide                 1305-79-9
n-Hexanoic Acid                  142-62-1
cyclohexyl acetate               622-45-7
diacetyl                         431-03-8
dimethyl carbonate               616-38-6
ethyl butyraldehyde              97-96-1
Ethyl crotonate                  623-70-1
ethyl isobutyrate                97-62-1
ethyl nitrite                    109-95-5
fumaric acid                     110-17-8
hexaldehyde                      66-25-1
isobutyric acid                  79-31-2
methyl isovalerate               556-24-1
methyl propionate                554-12-1
methyl valeraldehyde             123-15-9
nitrosyl chloride                2696-92-6
octafluorocyclobutane            115-25-3
peroxyacetic acid                79-21-0
propyl formate                   110-74-7
propyl mercaptan                 107-03-9
Sodium aluminate                 1302-42-7
sodium chlorite                  7758-19-2
Terephthalic Acid                100-21-0
allyl isothiocyanate             57-06-7
Vitamin B1                       59-43-8
Valproic acid                    99-66-1
Ethoxyquin                       91-53-2
n-Amyl Ethyl Ketone              106-68-3
Nabam                            142-59-6
Sodium sulfide                   1313-82-2
Thiocyanic acid                  463-56-9
2-Methyl-5-(1-methylethenyl)-    2244-16-8
2-cyclohexene-1-one
4-(2,6,6-Trimethyl-2-            127-41-3
cyclohexen-1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-            14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Isoamyl propionate               105-68-0
3-Methylbutanoic acid            503-74-2
L-Menthone                       14073-97-3
4-Ethylphenol                    123-07-9
o-cresol                         95-48-7
dimethyl-Carbamodithioic acid,   128-04-1
sodium salt
Anethole                         104-46-1
Dimethyl terephthalate           120-61-6
propyl gallate                   121-79-9
L-Ascorbic Acid Sodium Salt      134-03-2
4-Hexylresorcinol                136-77-6
Estragole                        140-67-0
L-monosodium glutamate           142-47-2
Malonaldehyde, sodium salt       24382-04-5
Butylated hydroxyanisole         25013-16-5
allyl 3-methylbutyrate           2835-39-4
DL-monosodium glutamate          32221-81-1
3-Acetyl-6-methyl-2,4-           520-45-6
pyrandione
L-Glutamic Acid                  56-86-0
DL-alpha-tocopheryl acetate      58-95-7
D-limonene                       5989-27-5
Calcium Acetate                  62-54-4
Erythorbic Acid Monosodium       6381-77-7
Salt
Ethyl methylphenylglycidate      77-83-8
2,4,6-Trinitro-1,3-dimethyl-5-   81-15-2
tert-butylbenzene
Dimethoxane                      828-00-2
3,5-Di-tert-butyl-4-             88-26-6
hydroxybenzyl alcohol
6-Methylquinoline                91-62-3
alpha-Methylbenzyl alcohol       98-85-1
Nicotinamide                     98-92-0
3,4-Dihydrocoumarin              119-84-6
Geranyl Acetate                  105-87-3
Sodium(2-Ethylhexyl)Alcohol      126-92-1
Sulfate
Cyclohexanol, 5-methyl-2-(1-     89-78-1
methylethyl)-,
(1alpha,2beta,5alpha)-
(+)-Camphor                      464-49-3
(1S)-(−)-alpha-Pinene            7785-26-4
1,3-Dihydroxy-5-methylbenzene    504-15-4
1,5-Naphthalenedisulfonic Acid   1655-29-4
Disodium Salt
1-Hydroxy-2-naphthoic Acid       86-48-6
1-Penten-3-ol                    616-25-1
1-Phenyl-1-propanol              93-54-9
10-Undecylenic Acid              112-38-9
2′-Hydroxyacetophenone           118-93-4
2,4-Dihydroxybenzoic Acid        89-86-1
2-Acetylfuran                    1192-62-7
2-Furancarboxylic Acid           88-14-2
2-Isopropylphenol                88-69-7
2-Ketoglutaric Acid              328-50-7
2-Ketovaline                     759-05-7
2-n-Propylphenol                 644-35-9
2-Naphthalenethiol               91-60-1
2-Phenyl-1-propanol              1123-85-9
3,3′-Thiodipropionic Acid        111-17-1
3,5,5-Trimethylhexanal           5435-64-3
3-Phenyl-1-propanol              122-97-4
3-Phenylpropionic Acid           501-52-0
4-Aminosalicylic Acid            65-49-6
4-Ethoxyphenol                   622-62-8
4-Hydroxybenzoic Acid            99-96-7
4-Phenyl-2-butanol               2344-70-9
4-tert-Octylphenol               140-66-9
Allyl Cinnamate                  1866-31-5
Allyl Mercaptan                  870-23-5
alpha-L-Rhamnose                 3615-41-6
Alpha-Terpineol                  98-55-5
Anisic Acid                      100-09-4
Benzalacetone                    122-57-6
Benzaldehyde Dimethylacetal      1125-88-8
Benzyl Ether                     103-50-4
Benzyl Formate                   104-57-4
Benzyl Mercaptan                 100-53-8
Benzyl Salicylate                118-58-1
Calcium Citrate                  813-94-5
Calcium Glycerophosphate         27214-00-2
Calcium Hypophosphite            7789-79-9
Calcium Iodate                   7789-80-2
Propanoic acid, 2-hydroxy-,      814-80-2
calcium salt (2:1)
Calcium Phosphate Tribasic       7758-87-4
Calcium Propionate               4075-81-4
Calcium Pyrophosphate            7790-76-3
Cholic Acid                      81-25-4
Choline                          123-41-1
Choline Bitartrate               87-67-2
trans-Cinnamic Aldehyde          14371-10-9
Cinnamyl Alcohol                 104-54-1
Citronellol                      106-22-9
Copper(I)Iodide                  7681-65-4
D-(+)-Glucono-1,5-lactone        90-80-2
D-(−)-Tartaric Acid              147-71-7
D-Isoascorbic Acid               89-65-6
D-Tyrosine                       556-02-5
Sodium dehydroacetate            4418-26-2
Deoxycholic Acid                 83-44-3
Dibenzyl Ketone                  102-04-5
Diethyl L-(+)-Tartrate           87-91-2
Diethyl Succinate                123-25-1
Dimethylacetal                   534-15-6
DL-Cystine                       923-32-0
DL-Proline                       609-36-9
DL-Tartaric Acid                 133-37-9
DL-Tyrosine                      556-03-6
DL-Valine                        516-06-3
Enanthoic Acid                   111-14-8
Erythorbic Acid Sodium Salt      7378-23-6
Ethyl 2-Aminobenzoate            87-25-2
Ethyl Cinnamate                  103-36-6
Ethyl n-Valerate                 539-82-2
Ethyl Phenylacetate              101-97-3
Ethyl Salicylate                 118-61-6
Ethyl Sulfide                    352-93-2
Ethyl Vanillin                   121-32-4
Ethylene Mercaptan               540-63-6
Farnesene                        502-61-4
Folic acid                       59-30-3
gamma-Nonanolactone              104-61-0
gamma-Valerolactone              108-29-2
Gluconic Acid                    526-95-4
Gluconic Acid Potassium Salt     299-27-4
Glutaric Acid                    110-94-1
Guanosine-5′-monophosphate,      1333479
disodium salt
Heliotropine                     120-57-0
Hippuric Acid                    495-69-2
Hydroquinone Dimethyl Ether      150-78-7
Inosine-5′-monophosphate         4691-65-0
Sodium Salt
iso-Amyl Mercaptan               541-31-1
Isoamyl Salicylate               87-20-7
iso-Butyl n-Hexanoate            105-79-3
isovaleraldehyde                 590-86-3
Isoamyl Benzoate                 94-46-2
Isoamyl Formate                  110-45-2
Isoamyl n-Butyrate               106-27-4
Isoamylamine                     107-85-7
Isobutyl n-Butyrate              539-90-2
Isocaproic Acid                  646-07-1
Isoeugenol                       97-54-1
Isopropyl Benzoate               939-48-0
Isopropyl Formate                625-55-8
Isopropyl N-Butyrate             638-11-9
Isopropyl Propionate             637-78-5
isobutyl Mercaptan               513-44-0
L-(+)-Isoleucine                 73-32-5
L-(−)-Apple Acid                 97-67-6
L-2-Aminopropionic Acid          56-41-7
L-Aspartic acid                  56-84-8
L-Carnitine                      541-15-1
L-Cysteine Hydrochloride         52-89-1
L-Glutamic Acid Hydrochloride    138-15-8
L-Glutamine                      56-85-9
L-Hydroxyproline                 51-35-4
L-Proline                        147-85-3
L-Serine                         56-45-1
L-Threonine                      72-19-5
L-Valine                         72-18-4
N-Acetylglycine                  543-24-8
n-Amyl Formate                   638-49-3
n-Amyl n-Caproate                540-07-8
n-Butyl n-Caproate               626-82-4
n-Butyl Propionate               590-01-2
n-Butyl Salicylate               2052-14-4
n-Decanoic Acid                  334-48-5
n-Hexyl Mercaptan                111-31-9
n-Propyl Benzoate                2315-68-6
n-Propyl Isobutyrate             644-49-5
n-Tetradecanoic Acid             544-63-8
Nitrilotriacetic Acid            5064-31-3
Trisodium Salt
o-Toluenethiol                   137-06-4
Orotic Acid                      65-86-1
p-Acetamidobenzoic Acid          556-08-1
p-Anise Alcohol                  105-13-5
Phenoxyacetic Acid               122-59-8
Phenyl Acetate                   122-79-2
Piperine                         94-62-2
Pivalic Acid                     75-98-9
Potassium Benzoate               582-25-2
Potassium Diphosphate            7320-34-5
Potassium Hypophosphite          7782-87-8
Potassium Metaphosphate          7790-53-6
Potassium Sulfite                10117-38-1
Quinine Hydrochloride            130-89-2
sec-Amyl Alcohol                 6032-29-7
Sodium D-Pantothenate            867-81-2
Di(2-ethylhexyl) sulfosuccinic   577-11-7
acid, sodium salt
Sodium Sorbate                   7757-81-5
Succinic acid, disodium salt     150-90-3
Sodium Taurocholate              145-42-6
Taurine                          107-35-7
Thiamine Nitrate                 532-43-4
Thioanisole                      100-68-5
Tiglic Acid                      80-59-1
Tri-n-butyrin                    60-01-5
Triacetin                        102-76-1
Trisodium Citrate                68-04-2
Veratraldehyde                   120-14-9
Veratrole                        91-16-7
Vitamin P                        520-26-3
Vitamin U Chloride               582174
L-methionine                     63-68-3
2-Chloro-1-propanol              78-89-7
2-Ethylbutyric acid              88-09-5
2-Methylbutyraldehyde            96-17-3
2-Methyl-5-ethylpyridine         104-90-5
n-propyl butyrate                105-66-8
Ethyl caprylate                  106-32-1
Propyl propionate                106-36-5
2-Methylpyrazine                 109-08-0
3,3,5-Trimethyl-1-cyclohexanol   116-02-9
Ethyl caproate                   123-66-0
o-methoxybenzaldehyde            135-02-4
2,4-Hexadienal                   142-83-6
3-Hexanone                       589-38-8
3-Methyl-2-butanol               598-75-4
Methyl isopropenyl ketone        814-78-8
3-Methyl-2-butanethiol           2084-18-6
3,5,5-Trimethylhexanol           3452-97-9
Methylglyoxal                    78-98-8
Malonaldehyde                    542-78-9
1,4-Dithiane                     505-29-3
Amylcinnamaldehyde               122-40-7
Benzyl cinnamate                 103-41-3
tert-Butylhydroquinone           1948-33-0
Fusidic Acid Sodium Salt         751-94-0
Hydroxycitronellal               107-75-5
Musk ketone                      81-14-1
L-Asparagine                     70-47-3
phenethyl acetate                103-45-7
Riboflavin-5-Phosphate           146-17-8
Potassium Sodium Tartrate        304-59-6
Galactaric acid                  526-99-8
Sodium Tartrate                  868-18-8
trisodium phosphate              7601-54-9
Disodium Pytophosphate           7758-16-9
Magnesium chloride               7786-30-3
Sodium Polymethacrylate          54193-36-1
propiophenone                    93-55-0
2-ethylhexanoic acid             149-57-5
3,7,7-trimethyl bicyclohep-3-    13466-78-9
ene
2,6-dimethyl-4-heptanol          108-82-7
5-isopropyl-2-methyl-phenol      499-75-2
L-Bornyl acetate                 5655-61-8
caryophyllene                    87-44-5
hydroxymethylpyrone              118-71-8
neosperidin dihydrochalcone      20702-77-6
2,2-Dibromo-3-                   10222-01-2
nitrilopropionamide
Xylitol                          87-99-0
Sulfosalicylic acid              97-05-2
Riboflavin 5′-(dihydrogen        130-40-5
phosphate), monosodium salt
Ethylenediaminetetraacetic       139-33-3
acid, disodium salt
Gallic acid                      149-91-7
Carbonic acid                    463-79-6
Potassium carbonate,             6381-79-9
sesquihydrate
Magnesium phosphate tribasic     7757-87-1
diallyl sulfide                  592-88-1
ethyl 4-oxopentanoate            539-88-8
methyl caproate                  106-70-7
isopropyl isobutyrate            617-50-5
diethyl hydroxybutanedioate      2065419
propyl isopentanoate             557-00-6
benzyl ethyl ether               539-30-0
isobutyl isopentanoate           589-59-3
propyl hexanoate                 626-77-7
4-methylquinoline                491-35-0
methyl cinnamate                 103-26-4
cumic alcohol                    536-60-7
thujone                          471-15-8
dihydrocarveol                   619-01-2
fenchyl alcohol                  1632-73-1
Nerol                            106-25-2
isopentyl isopentanoate          659-70-1
methyleugenol                    93-15-2
methyl 2-naphthyl ketone         93-08-3
diphenyldisulfide                882-33-7
citronellyl acetate              150-84-5
menthyl acetate                  89-48-5
menthyl isovalerate              16409-46-4
5-Ethyl-3-hydroxy-4-methyl-      698-10-2
2(5H)-furanone
malic acid                       6915-15-7
3-methylbutanoic acid butyl      109-19-3
ester
3-phenyloxiranecarboxylic acid   121-39-1
ethyl ester
1,2-Benzisothiazol-3(2H)-one     6381-61-9
1,1-dioxide, ammonium salt
1-methyl-4-(1-methylethyl)-      99-85-4
1,4-Cyclohexadiene
3-mercapto-2-Butanol             54812-86-1
(1R)-2,6,6-                      7785-70-8
trimethylbicyclo[3.1.1]hept-2-ene
(1S)-6,6-dimethyl-2-             18172-67-3
methylenebicyclo[3.1.1]heptane
1-methyl-4-(1-                   586-62-9
methylethylidene)cyclohexene
1-(3-pyridinyl)ethanone          350-03-8
1-pyrazinylethanone              22047-25-2
1-(2-furyl)-2-propanone          6975-60-6
1-Penten-3-one                   1629-58-9
2,3-pentanedione                 600-14-6
2,5-dimethylpyrazine             123-32-0
2-isobutyl-3-methoxypyrazine     24683-00-9
4-methyl-2,3-pentanedione        7493-58-5
5-methylfurfural                 620-02-0
Dimethyltrisulfide               3658-80-8
furfuryl acetate                 623-17-6
furfurylmethylether              13679-46-4
terpinen-4-ol                    562-74-3
Calcium sorbate                  7492-55-9
Potassium lactate                996-31-6
1-Hydroxyethylidene-1,1-         2809-21-4
diphosphonic acid
L-glutamic acid monopotassium    19473-49-5
salt
3-methyl-2-buten-1-ol            556-82-1
phenylethanal                    122-78-1
4′-Methoxyacetophenone           100-06-1
L-borneol                        464-45-9
2,4-Hexadien-1-ol                111-28-4
D-Fenchone                       4695-62-9
3-Phenylpropyl formate           104-64-3
Cinnamyl formate                 104-65-4
D-galacturonate                  685-73-4
D-glucuronate                    1700908
5′ IMP                           131-99-7
1-Methoxy-4-methylbenzene        104-93-8
2-Methylbutanoic acid            116-53-0
2,4,6-Tribromophenol             118-79-6
3-Ethyl pyridine                 536-78-7
Zinc acetate                     557-34-6
Methyl pentanoate                624-24-8
Methylthioethane                 624-89-5
3-Penten-2-one                   625-33-2
Glycocholic acid                 475-31-0
m-Methoxybenzoic acid            586-38-9
alpha-Hydroxypropionic acid      598-82-3
Methyl 2-furoate                 611-13-2
2-Furancarboxylic acid, propyl   615-10-1
ester
Benzylacetoacetic acid, ethyl    620-79-1
ester
2,5-Dimethyl pyrrole             625-84-3
4-methyl-1,1′-biphenyl           644-08-6
p-Isopropylacetophenone          645-13-6
4-methyl-thiazole                693-95-8
gamma-Decalactone                706-14-9
2-acetylpyrrole                  1072-83-9
2-acetylpyridine                 1122-62-9
tetramethyl-pyrazine             1124-11-4
Methyl 4-phenylbutyrate          2046-17-5
2,3,6-trimethyl-phenol           2416-94-6
2-Methoxypyrazine                3149-28-8
2-Ethylfuran                     3208-16-0
2,3-dimethyl-pyrazine            5910-89-4
Thiophenethiol                   7774-74-5
o-Tolyl isobutyrate              36438-54-7
cis-3-Hexenyl pyruvate           68133-76-6
cis-3-Hexenyl cis-3-hexenoate    61444-38-0
trans-2-Hexenyl isovalerate      68698-59-9
trans-2-Hexenyl formate          53398-78-0
trans-2-Hexenyl valerate         56922-74-8
1-Octen-3-yl butyrate            16491-54-6
Methyl 4-(methylthio)butyrate    53053-51-3
2,4-Octadien-1-ol                18409-20-6
2,4-Nonadien-1-ol                62488-56-6
2,4-Decadien-1-ol                18409-21-7
(e,z)-2,6-Nonadienyl acetate     68555-65-7
3-Hexenal                        4440-65-7
Tetrahydro-2-furanmethanol       637-64-9
acetate
Methyl benzaldehyde              1334-78-7
Dodecylsulfonic acid             1510-16-3
Methylethyl disulfide            4253-89-8
Farnesol                         4602-84-0
Thiobenzoic acid, S-methyl       5925-68-8
ester
Hexyl benzoate                   6789-88-4
2,5-Diethyltetrahydrofuran       41239-48-9
Zinc hydrosulfite                7779-86-4
(2R,3S)-Tartaric Acid            147-73-9
Ethylsulfuric acid               540-82-9
1,2,2-Trimethyl-1,3-             5394-83-2
cyclopentanedicarboxylic acid
2-Methyl-3-buten-2-ol            115-18-4
trans-2-Hexenal                  6728-26-3
4-Hexen-3-one                    2497-21-4
1-Hexen-3-ol                     4798-44-1
2-Methyl-1-butanethiol           1878-18-8
4-Methylcyclohexanone            589-92-4
3-Heptanol                       589-82-2
o-methylanisole                  578-58-5
trans-2-octenal                  2363-89-5
2,3,4-Trimethyl-3-pentanol       3054-92-0
Acetylacetaldehyde dimethyl      5436-21-5
acetal
p-methylacetophenone             122-00-9
o-aminoacetophenone              551-93-9
4-Propylphenol                   645-56-7
2,4-Dimethylanisole              6738-23-4
Benzyl methyl sulfide            766-92-7
Methyl phenylacetate             101-41-7
4-Ethoxybenzaldehyde             10031-82-0
p-tolyl acetate                  140-39-6
2,6-Dimethoxyphenol              91-10-1
Isoborneol                       124-76-5
Methyl 2-methoxybenzoate         606-45-1
Phenylacetaldehyde dimethyl      101-48-4
acetal
3-Phenylpropyl acetate           122-72-5
Ethyl 3-phenylpropionate         2021-28-5
Benzyl butyrate                  103-37-7
Anisyl acetate                   104-21-2
Isobutyl phenylacetate           102-13-6
p-vinylphenol                    2628-17-3
o-tolyl acetate                  533-18-6
2,5-Dihydroxybenzoic acid        490-79-9
o-methoxyphenyl acetate          613-70-7
Lactobionic acid                 96-82-2
Magnesium hydrogen phosphate     7782-75-4
trihydrate
Iberverin                        505-79-3
alpha-methylcinnamaldehyde       101-39-3
benzyl phenylacetate             102-16-9
1,3-dimercaptopropane            109-80-8
p-cymen-8-ol                     1197-01-9
phenethyl anthranilate           133-18-6
trihydroxybutyrophenone          1421-63-2
o-methoxycinnamaldehyde          1504-74-1
3-propylidene phthalide          17369-59-4
trans,trans-2,4-decadienal       25152-84-5
piperonyl acetate                326-61-4
2,3-hexanedione                  3848-24-6
isopropyl phenylacetate          4861-85-2
ethyl 3-hydroxybutyrate          5405-41-4
furfural acetone                 623-15-4
beta-(2-furyl)acrolein           623-30-3
linalyl anthranilate             7149-26-0
citral diethyl acetal            7492-66-2
allyl anthranilate               7493-63-2
acetyl tributyl citrate          77-90-7
butyl anthranilate               7756-96-9
cyclohexyl anthranilate          7779-16-0
isoamyl cinnamate                7779-65-9
isobutyl anthranilate            7779-77-3
carvyl acetate                   97-42-7
carveol                          99-48-9
3-(Methylthio)propionaldehyde    3268-49-3
Alpha-damascone                  43052-87-5
Dimethyldicarbonate              4525-33-1
Procaine                         59-46-1
5-hydroxy-6-methyl-3,4-          65-23-6
pyridinedimethanol
2-methoxy-Naphthalene            93-04-9
Methyl nicotinate                93-60-7
Ethyl benzoylacetate             94-02-0
Phenethyl benzoate               94-47-3
2-methyl-pentanoic acid          97-61-0
Cyclohexanecarboxylic acid       98-89-5
Methyl b-phenylpropionate        103-25-3
Benzyl 3-methyl butanoate        103-38-8
Naphthalene-2-sulfonic acid      120-18-3
Methyl 4-methoxybenzoate         121-98-2
3-Phenylprop-2-enyl cinnamate    122-69-0
7-methyl-3-methylene-1,6-        123-35-3
Octadiene
Levulinic acid                   123-76-2
2-Mercaptobenzoic acid           147-93-3
m-Dimethoxybenzene               151-10-0
3-butyl-1(3H)-isobenzofuranone   6066-49-5
5-Methylquinoxaline              13708-12-8
2-Ethyl Pyrazine                 13925-00-3
trimethyl-pyrazine               14667-55-1
2-ethyl-3-methyl-pyrazine        15707-23-0
2,3-diethyl-pyrazine             15707-24-1
2,3-diethyl-5-methyl-pyrazine    18138-04-0
2-Methylthiopyrazine             21948-70-9
5-Methyl-3H-furan-2-one          591-12-8
cis-3-Hexen-1-ol                 928-96-1
3,7-Dimethyl-1,3,6-octatriene    13877-91-3
calcium cyclamate                139-06-0
aconitic acid                    499-12-7
2-Dehydrolinalool                29171-20-8
2-Mercaptopropionic acid         79-42-5
3-Methyl-2-butenal               107-86-8
Allylacetic acid                 591-80-0
Allyl cyclohexylacetate          4728-82-9
Allyl cyclohexylpropionate       2705-87-5
Allyl phenoxyacetate             7493-74-5
Allyl phenylacetate              1797-74-6
Allyl alpha-ionone               79-78-7
Butyl butyrolactate              7492-70-8
Cinnamyl isobutyrate             103-59-3
Cinnamyl propionate              103-56-0
Dibenzyl disulfide               150-60-7
Isobornyl acetate                125-12-2
Methyl heptyne carbonate         111-12-6
Triethyl citrate                 77-93-0
gamma-Undecalactone              104-67-6
alpha-Amylcinnamyl alcohol       101-85-9
1,3,4,6,7,8 -Hexahydro-          1222-05-5
4,6,6,7,8,8-hexamethyl
cyclopenta[g] [2]benzopyran
2-Ethylbutyl acetate             10031-87-5
Triphosphoric acid,              13845-36-8
pentapotassium salt
L-(+)-Lactic acid                79-33-4
Mannitol                         87-78-5
2-Methoxy-4-methylphenol         93-51-6
1,2,3-Propanetricarboxylic       144-33-2
acid, 2-hydroxy-, disodium
salt
Ethanesulfonic acid, 2-          1562-00-1
hydroxy-, monosodium salt
2-Methoxy-4-propylphenol         2785-87-7
3,7-Dimethyl-3-octanol           78-69-3
2-Pentyl furan                   3777-69-3
Butanoic acid, 3-oxo-, butyl     591-60-6
ester
4-(4-Hydroxy-4-methyl pentyl)-   31906-04-4
3-cyclohexene-1-carboxaldehyde
Methyl 3-oxo-2-                  24851-98-7
pentylcyclopentaneacetate
Naphthalene, 2-(2-               2173-57-1
methylpropoxy)-
Perillol                         536-59-4
2-Acetyl-1-methylpyrrole         932-16-1
4-Allyl-2,6-dimethoxyphenol      6627-88-9
Butyl levulinate                 2052-15-5
D-(+)-Camphoric acid             124-83-4
D(+)-10-Camphorsulfonic acid     3144-16-9
L-(−)-Carvone                    6485-40-1
(−)-Carvyl propionate            97-45-0
(−)-Caryophyllene oxide          1139-30-6
Cyclohexylacetic acid            5292-21-7
3-Cyclopentylpropionic acid      140-77-2
(−)-Dihydrocarvyl acetate        20777-49-5
3,3-Dimethylacrylic acid         541-47-9
2,4-Dimethylbenzaldehyde         15764-16-6
1,4-Dithiane-2,5-diol            40018-26-6
Ethanesulfonic acid              594-45-6
Ethyl butyrylacetate             3249-68-1
Ethyl (methylthio) acetate       4455-13-4
Ethyl pyruvate                   617-35-6
Ethyl sorbate                    2396-84-1
5-Formyl-2-furansulfonic acid,   31795-44-5
sodium salt
Furfuryl mercaptan               98-02-2
1,6-Hexanedithiol                1191-43-1
trans-2-Hexenoic acid            13419-69-7
trans-2-Hexen-1-ol               928-95-0
4-(4-Hydroxyphenyl)-2-butanone   5471-51-2
Isopulegol                       89-79-2
Isopulegyl acetate               89-49-6
2-Ketobutyric acid               600-18-0
(−)-Limonene                     5989-54-8
4-Methoxyphenylacetone           122-84-9
Methyl cyclohexanecarboxylate    4630-82-4
3-Methylcyclohexanone            591-24-2
3-Methyl-2-cyclohexen-1-one      1193-18-6
3-Methyl-1,2-cyclopentanedione   765-70-8
3-Methyl-2-cyclopenten-1-one     2758-18-1
N-Methyl-D-glucamine             6284-40-8
Methyl 3-                        13532-18-8
(methylthio)propionate
4-Methyl-5-thiazoleethanol       137-00-8
5-Methyl-2-                      13679-70-4
thiophenecarboxaldehyde
DL-3-Methylvaleric acid          105-43-1
(−)-Myrtenal                     564-94-3
Nopol                            128-50-7
gamma-Octanoic lactone           104-50-7
3-Octanol                        589-98-0
E-2-Octenoic acid                1871-67-6
Pamoic acid                      130-85-8
4-Phenyl-2-butyl acetate         10415-88-0
1-Phenyl-1,2-propanedione        579-07-7
2-Phenylpropyl butyrate          80866-83-7
2-Phenylpropyl isobutyrate       65813-53-8
cis-2-Hexen-1-ol                 928-94-9
Bis(methylthio)methane           1618-26-4
Magnesium carbonate hydroxide,   39409-82-0
Light
N-Acetyl-L-methionine            65-82-7
4-Methyl-5-vinylthiazole         1759-28-0
2-Methyl-1-phenyl-2-propanol     100-86-7
3-Phenylpropionaldehyde          104-53-0
N-Benzyl-2-phenylethylamine      3647-71-0
1-Phenylethyl propionate         120-45-6
3-Phenylpropyl isobutyrate       103-58-2
Allyl hexanoate                  123-68-2
alpha, 4-Dimethylbenzylalcohol   536-50-5
(−)-Menthyl lactate              59259-38-0
2,6-Dimethylthiophenol           118-72-9
2,4,5-Trimethylthiazole          13623-11-5
Ethyl 3-(methylthio)propionate   13327-56-5
Phenylethyl isovalerate          140-26-1
2-Propylpyrazine                 18138-03-9
2-Methyltetrahydrofuran-3-one    3188-00-9
Ethyl 2-                         23747-43-5
(methyldithio)propionate
3,4-Dimethyl-1,2-                13494-06-9
cyclopentanedione
Difurfurylsulfide                13678-67-6
Difurfuryldisulfide              4437-20-1
3-(Methylthio)propanol           505-10-2
Methyl phenyl disulfide          14173-25-2
2-(Methyldithio)-                67952-60-7
isobutyraldehyde
Methyl 2-thiofuroate             13679-61-3
2-Isobutylthiazole               18640-74-9
4-Methyl-5-thiazolylethyl        656-53-1
acetate
2-Acetylthiazole                 24295-03-2
2-Ethyl-3,5(6)-                  27043-05-6
dimethylpyrazine
5-Methyl-6,7-dihydro-5H-         23747-48-0
cyclopenta(b)pyrazine
Cinnamyl acetate                 103-54-8
2,5-Dihydroxy-2,5-dimethyl-      55704-78-4
1,4-dithiane
5,6,7,8-Tetrahydroquinoxaline    34413-35-9
2-Methyl-3-furanethiol           28588-74-1
Styrallyl acetate                93-92-5
2-Methylhexanoic acid            4536-23-6
2-Methylheptanoic acid           1188-02-9
2,2,6-Trimethylcyclohexanone     2408-37-9
L-Tyrosine ethyl ester           4089-07-0
hydrochloride
Ethyl 4-methoxybenzoate          94-30-4
4-Ethylbenzaldehyde              4748-78-1
N-Ethyl-p-menthane-3-            39711-79-0
carboxamide
1-(2-Furyl)-1,3-butanedione      25790-35-6
Menthofuran                      494-90-6
Methylsulfuric acid sodium       512-42-5
salt
Sucrose diacetate                126-13-6
hexaisobutyrate
N,2,3-Trimethyl-2-               51115-67-4
isopropylbutamide
Tripropionin                     139-45-7
(+/−)-Citronellic acid           502-47-6
5-Acetyl-2,4-dimethylthiazole    38205-60-6
Neryl acetate                    141-12-8
Benzyl propionate                122-63-4
1R-(−)-Camphorsulfonic acid      35963-20-3
3,4-Hexanedione                  4437-51-8
cis-3-Hexenoic acid              4219-24-3
cis-4-Heptenal                   6728-31-0
(E,Z)-2,6-nonadienal             557-48-2
trans-2,trans-6-Nonadienal       17587-33-6
4-Methyl-2-pentenal              5362-56-1
cis-6-Nonenal                    2277-19-2
Methyl propyl disulfide          2179-60-4
8-p-Menthen-1-ol                 138-87-4
p-Menthan-2-one                  499-70-7
Bisabolene                       495-62-5
Ethyl cyclohexanecarboxylate     3289-28-9
Phenylpyruvate                   156-06-9
Hydroxypyruvate                  1113-60-6
4-Methyl-2-oxopentanoate         816-66-0
(+)-Neomenthol                   2216-52-6
trans-Citral                     141-27-5
Piperitenone                     491-09-8
Sabinene hydrate                 546-79-2
Perillyl aldehyde                2111-75-3
2-Hydroxyethanesulfonate         107-36-8
Acetyl isovaleryl                13706-86-0
Acetyl valeryl                   96-04-8
Butylidene phthalide             551-08-6
Carvacryl ethyl ether            4732-13-2
Ethyl vanillin propylene         68527-76-4
glycol acetal
Hexyl hexanoate                  6378-65-0
2-Methyl-5-(methylthio)-furan    13678-59-6
2-Methyl-4-pentenoic acid        1575-74-2
2-Methyl-4-propyl-1,3-           67715-80-4
oxathiane
3-Methylthio-1-hexanol           51755-66-9
cis-6-Nonenol                    35854-86-5
Rose oxide                       16409-43-1
L-Linalool                       126-91-0
5,6-Dimethyl-8-                  4674-50-4
isopropenylbicyclo[4.4.0]dec-
1-en-3-one
2-Ethyl-3,5-dimethylpyrazine     13925-07-0
2-Isopropylpyrazine              29460-90-0
2-Isobutyl-3-methyl-pyrazine     13925-06-9
2-Methoxy-3-sec-butyl-pyrazine   24168-70-5
2-Methylthio-3(6)-methyl-        67952-65-2
pyrazine
Benzylcarbinyl propionate        122-70-3
Bornyl acetate                   76-49-3
furaneol                         3658-77-3
Methoxycinnamaldehyde            1963-36-6
Methylphenol, hydrogen sulfate   68127-34-4
Lactitol monohydrate             81025-04-9
2H-Pyrrole, 3,4-dihydro-         5724-81-2
2-Butenal, 2-methyl-, (E)-       497-03-0
2-Pentenal                       764-39-6
Ethanethioic acid, S-methyl      1534-08-3
ester
2-Hexenal                        505-57-7
2-Methyl-2-pentenal              623-36-9
Cyclopentanethiol                1679-07-8
Butane, 2-ethoxy-                2679-87-0
S-Ethyl thioacetate              625-60-5
ethyl methyl carbonate           623-53-0
3(2H)-Furanone, 2,5-dimethyl-    14400-67-0
Allyl propionate                 2408-20-0
methyl 2-methylbutanoate         868-57-5
2-Butanone, 1-(methylthio)-      13678-58-5
Ethanethioic acid, S-propyl      2307-10-0
ester
1,2-Butanedithiol                16128-68-0
6-Methyl-3,5-heptadiene-2-one    1604-28-0
2-Octen-4-one                    4643-27-0
2,5-dimethyl-3-furanthiol        55764-23-3
2-Heptenoic acid                 18999-28-5
Butanoic acid, 2-propenyl        2051-78-7
ester
6-Methyl-5-hepten-2-ol           1569-60-4
trans-2-Octen-4-ol               20125-81-9
cis-3-Octen-1-ol                 20125-84-2
1-Butanol, 2-methyl-, acetate    624-41-9
4-methyl-alpha-methylstyrene     1195-32-0
trans-3-Phenyl-2-propen-1-ol     4407-36-7
Benzeneacetaldehyde, alpha-      93-53-8
methyl-
Benzene, (2-methoxyethyl)-       3558-60-9
Cyclohexene, 1-methyl-4-(1-      7705-14-8
methylethenyl)-, (+−)-
Phenol, 2-(methylthio)-          1073-29-6
2-Hexen-1-yl acetate             2497-18-9
3-Hexen-1-ol, acetate, (Z)-      3681-71-8
5-Hydroxy-4-octanone             496-77-5
butyl 2-methylpropanoate         97-87-0
Benzofuran-2-carboxaldehyde      4265-16-1
DL-Lysine                        70-54-2
1-Hexanethiol, 2-ethyl-          7341-17-5
2′,4′-Dimethylacetophenone       89-74-7
2-Pentylpyridine                 2294-76-0
1-Methoxy-4-propyl benzene       104-45-0
1-Hydroxy-2-methoxy-4-ethyl      2785-89-9
benzene
Nonalactone                      6008-27-1
Cyclohexyl propionate            6222-35-1
Allyl 2-ethylbutyrate            7493-69-8
Butanoic acid, 3-oxo-, 2-        7779-75-1
methylpropyl ester
n-Butyl pentanoate               591-68-4
3,7-Dimethyl-1-octanol           106-21-8
3-Buten-2-one, 3-methyl-4-       1901-26-4
phenyl-
2-Propenoic acid, 3-phenyl-,     1754-62-7
methyl ester, (E)-
Benzene, 4-ethenyl-1,2-          6380-23-0
dimethoxy-
Benzenepropanol, alpha,alpha-    103-05-9
dimethyl-
Benzene, (butoxymethyl)-         588-67-0
Dimethyl anthranilate            85-91-6
2-Hexanoylfuran                  14360-50-0
Cyclohexyl butyrate              1551-44-6
Naphthalene, 2-ethoxy-           93-18-5
Acetoacetic acid isoamyl ester   2308-18-1
Propanoic acid, 2-methyl-, 4-    103-93-5
methylphenyl ester
4-(4-Methoxyphenyl)-2-butanone   104-20-1
Isobutyl benzoate                120-50-3
Benzene, 1,2-dimethoxy-4-(1-     93-16-3
propenyl)-
beta-                            10415-87-9
Phenylethylmethylethylcarbinol
1,1-Dimethoxy-2-phenylpropane    90-87-9
Geranyl formate                  105-86-2
Bornyl formate                   7492-41-3
6-Octen-1-ol, 3,7-dimethyl-,     105-85-1
formate
Benzeneacetic acid, butyl        122-43-0
ester
3,5,9-Undecatrien-2-one, 6,10-   141-10-6
dimethyl-
Anisyl propionate                7549-33-9
Butanoic acid, 3-phenyl-2-       103-61-7
propenyl ester
2-Propenoic acid, 3-phenyl-,     122-67-8
2-methylpropyl ester
Eugenyl acetate                  93-28-7
3-Methylbutyl phenylacetate      102-19-2
Benzoic acid, 2-(methylamino)-,  65505-24-0
2-methylpropyl ester
Phenoxy ethyl isobutyrate        103-60-6
Anisyl butyrate                  6963-56-0
2,6-Octadien-1-ol, 3,7-          105-91-9
dimethyl-, propanoate, (Z)-
Isobornyl propionate             2756-56-1
1,3,5-Trithiane, 2,2,4,4,6,6-    828-26-2
hexamethyl-
Geranyl N-butyrate               106-29-6
Geranyl isobutyrate              2345-26-8
Thiophene, 2,2′-dithiobis-       6911-51-9
2-Propenoic acid, 3-phenyl-,     7779-17-1
cyclohexyl ester
Benzeneacetic acid, 3-phenyl-    7492-65-1
2-propenyl ester
Anisyl phenylacetate             102-17-0
2-Propenoic acid, 3-phenyl-,     122-68-9
3-phenylpropyl ester
Geranyl phenylacetate            102-22-7
hexyl 2-methylbutyrate           10032-15-2
4-heptanolide                    105-21-5
Neral                            106-26-3
(E)-2-octenol                    18409-17-1
Ethyl 3-hydroxyhexanoate         2305-25-1
isopropyl hexanoate              2311-46-8
hexyl butanoate                  2639-63-6
bis(2-methyl-3-furyl)disulfide   28588-75-2
3-hydroxy-4,5-dimethyl-2(5H)-    28664-35-9
furanone
2-acetyl-2-thiazoline            29926-41-8
(E,E)-2,4-octadienal             30361-28-5
geranyl acetone                  3796-70-1
1-octen-3-one                    4312-99-6
3-mercapto-2-pentanone           67633-97-0
(Z)-3-hexenal                    6789-80-6
4-hexanolide                     695-06-7
5-octanolide                     698-76-0
delta-decalactone                705-86-2
4-vinylguaiacol                  7786-61-0
Amyl salicylate                  2050-08-0
Cyclohexyl formate               4351-54-6
Dimethylbenzylcarbinyl acetate   151-05-3
Geranyl propionate               105-90-8
Terpinyl acetate                 80-26-2
isopropyl 3-methylbutanoate      32665-23-9
isopropyl 2-methylbutanoate      66576-71-4
3-Hexenyl 3-methylbutanoate      10032-11-8
Isoamyl 2-methylbutyrate         27625-35-0
3-Octyl acetate                  4864-61-3
Benzyl isobutyrate               103-28-6
Cis-3-hexenyl butyrate           16491-36-4
Cis-3-hexenyl lactate            61931-81-5
Citronellyl butyrate             141-16-2
Citronellyl propionate           141-14-0
Isoamyl hexanoate                2198-61-0
1,3,5-Undecatriene               16356-11-9
1-Benzyloxy-2-methoxy-4-         120-11-6
propenyl benzene
1-Octen-3-yl acetate             198242
2-Acetyl-3-ethyl pyrazine        32974-92-8
2-Isopropyl-4-methyl thiazole    15679-13-7
2-Methyl-2-pentenoic acid        3142-72-1
2-sec-butyl thiazole             18277-27-5
4,5-Dimethyl thiazole            3581-91-7
4-(2,6,6-Trimethyl-2-            31499-72-6
cyclohexen-1-yl)butan-2-one
4-(2,6,6-Trimethyl cyclohexa-    23696-85-7
1,3-dienyl)but-2-en-4-one
Acetaldehyde phenethyl propyl    7493-57-4
acetal
Acetaldehyde ethyl cis-3-        28069-74-1
hexenyl acetal
Acetone propylene glycol         1193-11-9
acetal
Acetyl isoeugenol                93-29-8
2-Acetyl-5-methyl furan          1193-79-9
Allyl cyclohexylbutyrate         7493-65-4
Alpha,alpha-dimethylphenethyl    10094-34-5
butyrate
Alpha,alpha-dimethyl phenethyl   10058-43-2
formate
Alpha,beta-santalol              11031-45-1
Alpha-amyl cinnamaldehyde        91-87-2
dimethyl acetal
Alpha-fenchyl acetate            13851-11-1
Alpha-furfuryl pentanoate        36701-01-6
Alpha-ionol                      25312-34-9
6-Methyl-alpha-ionone            79-69-6
Alpha-methyl-p-                  103-95-7
isopropylphenylpropanaldehyde
Alpha-n-amyl-beta-phenylacryl    7493-78-9
acetate
Alpha-piperitone                 6091-50-5
Alpha-n-amyl-beta-phenyl acryl   7493-80-3
isovalerate
6-Amyl-alpha-pyrone              27593-23-3
Anisyl formate                   122-91-8
Benzylcarbinyl 2-methyl          24817-51-4
butyrate
Benzylcarbinyl 3-phenyl          103-53-7
propenoate
Benzylcarbinyl alpha-toluate     102-20-5
Benzylcarbinyl butyrate          103-52-6
Benzylcarbinyl caproate          6290-37-5
Benzylcarbinyl formate           104-62-1
Benzylcarbinyl isobutyrate       103-48-0
Benzylcarbinyl salicylate        87-22-9
Benzylcarbinyl tiglate           55719-85-2
Benzyl dipropyl ketone           7492-37-7
Benzyl tiglate                   37526-88-8
Beta-homocyclocitral             472-66-2
Beta-ionol                       22029-76-1
3-Phenylpropyl propanoate        122-74-7
Bois de rose oxide               7392-19-0
Butyl 2-methyl butyrate          15706-73-7
Butyl cinnamate                  538-65-8
ortho-sec-Butyl cyclohexanone    14765-30-1
isobutyl cis-2-methyl-2-         7779-81-9
butenoate
5-n-Butyl-delta-valerolactone    3301-94-8
Campholenic aldehyde             4501-58-0
Cedran-8-yl acetate              77-54-3
Cinnamyl isovalerate             140-27-2
Cis-3-hexenyl benzoate           25152-85-6
Cis-3-hexenyl caproate           31501-11-8
Cis-3-hexenyl formate            33467-73-1
Cis-3-hexenyl isobutyrate        41519-23-7
Cis-3-hexenyl phenylacetate      42436-07-7
Cis-3-hexenyl propionate         33467-74-2
Cis-3-hexenyl tiglate            67883-79-8
Cis-3-hexenyl valerate           35852-46-1
cis-4-Hepten-1-ol                6191-71-5
Cis-5-octen-1-ol                 64275-73-6
Citral dimethyl acetal           7549-37-3
Citronellyl isobutyrate          97-89-2
Citronellyl isovalerate          68922-10-1
Citronellyl valerate             7540-53-6
Citroxide                        7416-35-5
Cocal                            21834-92-4
p-Cresyl alpha-toluate           101-94-0
p-Cresyl isovalerate             55066-56-3
Dehydro-beta-cyclocitral         116-26-7
8,8-Diethoxy-2,6-dimethyl-2-     7779-94-4
octanol
5,7-Dihydro-2-methyl             36267-71-7
thieno(3,4-d)pyrimidine
2,5-Dihydro-4,5-dimethyl-2-(2-   65894-83-9
methyl propyl)thiazole
Dihydrojasmone                   1128-08-1
Dihydroxyacetophenone            28631-86-9
1,1-Dimethoxy-3,7-dimethyl-7-    141-92-4
octanol
3,7-Dimethyl-1,6-octadien-3-yl   126-64-7
benzoate
3,7-Dimethyl-1,6-octadien-3-yl   78-36-4
butyrate
3,7-Dimethyl-1,6-octadien-3-yl   78-35-3
isobutyrate
3,7-Dimethyl-1,6-octadien-3-yl   144-39-8
propanoate
cis-3,7-Dimethyl-2,6-octadien-   2345-24-6
1-yl 2-methyl propanoate
2,4-Dimethyl-3-cyclohexene-1-    68039-49-6
carboxaldehyde
2,6-Dimethyl-5-hepten-1-al       106-72-9
trans,cis-2,6-Dodecadien-1-al    21662-13-5
Eglantal                         26643-91-4
Ethyl E-2-hexenoate              27829-72-7
Ethyl tiglate                    5837-78-5
Ethyl trans-4-decenoate          76649-16-6
5-Ethyl-4-hydroxy-2-methyl-      27538-09-6
3[2H]furanone
2-Ethyl-4-methyl thiazole        15679-12-6
2,6,10-Trimethyl-2,6,10-         762-29-8
pentadecatrien-14-one
Guaiacyl phenyl acetate          4112-89-4
3-Hepten-2-one                   1119-44-4
trans-2-Hexen-1-ol               2305-21-7
Trans-2-hexenyl butyrate         53398-83-7
Hexyl phenylacetate              5421-17-0
Hexyl propionate                 2445-76-3
Hydroxycitronellol               107-74-4
Isobutyl 2-butenoate             589-66-2
Isobutyl salicylate              87-19-4
Isodihydro lavandulal            35158-25-9
Isoeugenyl phenyl acetate        120-24-1
Isopropyl alpha-                 1733-25-1
methylcrotonate
p-Menth-1-en-8-yl propionate     80-27-3
Menthalactone                    13341-72-5
3-Methoxy-p-cymene               1076-56-8
Methyl 4-methyl pentanoate       2412-80-8
alpha-Methyl benzyl formate      7775-38-4
2-Methylbutyl 2-                 2445-78-5
methylbutanoate
Methyl e-2-octenoate             2396-85-2
p-Methyl hydratropaldehyde       99-72-9
3-(5-Methyl-2-furyl)butanal      31704-80-0
Nerol oxide                      1786-08-9
trans,cis-2,6-Nonadien-1-ol      7786-44-9
trans-2-Octen-1-yl acetate       3913-80-2
3-Octen-2-one                    1669-44-9
2-Phenyl-2-butenal               4411-89-6
2-Propionylthiazole              43039-98-1
1-Hydroxy-2-butanone             5077-67-8
2-Butanone, 3-hydroxy-, (+−)-    52217-02-4
Thiazole, 2,5-dimethyl-          4175-66-0
Butanethioic acid, S-methyl      2432-51-1
ester
2,4-Hexadienoic acid, methyl     689-89-4
ester, (E,E)-
Benzeneacetaldehyde, 4-methyl-   104-09-6
Bicyclo[4.1.0]hept-3-ene,        498-15-7
3,7,7-trimethyl-, (1S)-
Ethyl 3-hexenoate                2396-83-0
1H-Pyrrole, 1-(2-                1438-94-4
furanylmethyl)-
6-Octenal, 3,7-dimethyl-, (R)-   2385-77-5
Ethanethioic acid, S-(2-         13678-68-7
furanylmethyl) ester
6-Octen-1-ol, 3,7-dimethyl-,     1117-61-9
(R)-
6-Octen-1-ol, 3,7-dimethyl-,     7540-51-4
(S)-
DL-Tetrohydrofurfuryl            637-65-0
propionate
Benzenepentanol                  10521-91-2
Cyclohexaneethanol, acetate      21722-83-8
Benzyl isobutyl ketone           5349-62-2
Butanoic acid, 3-oxo-,           5396-89-4
phenylmethyl ester
1,2-Ethanediamine, N,N′-         140-28-3
bis(phenylmethyl)-
2-Ethyl-3-hydroxy-4-pyrone       1110651
Dicyclohexyl disulfide           2550-40-5
Tetrahydrofurfuryl butyrate      2217-33-6
Thujone                          546-80-5
Benzyl alcohol, alpha-methyl-,   3460-44-4
butyrate
Citronellyl tiglate              24717-85-9
Lactitol                         585-86-4
Nonivamide                       2444-46-4
2-Acetoxy-3-butanone             4906-24-5
3-Acetyl-2,5-dimethylthiophene   230378
3-Acetyl-2-5dimethylfuran        10599-70-9
4-Acetyl-6-t-butyl-1,1-          13171-00-1
dimethylindan
Allyl 2-furoate                  4208-49-5
Allyl sorbate                    7493-75-6
Allyl thiopropionate             41820-22-8
Allyl tiglate                    7493-71-2
Amylcyclohexyl acetate           67874-72-0
Benzaldehyde glyceryl acetal     1319-88-6
Benzaldehyde propylene glycol    2568-25-4
acetal
Bornyl isovalerate               76-50-6
1,3-Butanedithiol                24330-52-7
2,3-Butanedithiol                4532-64-3
Butyl cinnamic aldehyde          7492-44-6
Cinnamyl benzoate                5320-75-2
Citral ethylene glycol acetal    66408-78-4
Citronellyloxyacetaldehyde       7492-67-3
Citronellyl phenylacetate        139-70-8
Cyclohexyl isovalerate           7774-44-9
Decalactone                      5579-78-2
2,5-Dimethyl-4-methoxy-3(2H)-    4077-47-8
furanone
6,10-Dimethyl-9-undecen-2-one    4433-36-7
2-Ethoxythiazole                 15679-19-3
Ethyl 2-mercaptopropionate       19788-49-9
Ethyl 2-methyl-4-pentenoate      53399-81-8
Ethyl 3-(2-furyl)propanoate      94278-27-0
Ethyl cyclohexanepropionate      10094-36-7
Ethyl (p-tolyloxy)acetate        67028-40-4
3-Ethyl-2-hydroxy-2-             21835-01-8
cyclopenten-1-one
Ethylene brassylate              105-95-3
2-Ethylfenchol                   18368-91-7
Furfuryl 3-methylbutanoate       13678-60-9
Furfuryl butyrate                623-21-2
Furfuryl isopropyl sulfide       1883-78-9
Furfuryl methyl sulfide          1438-91-1
Furfuryl propionate              623-19-8
Furfuryl thiopropionate          59020-85-8
Geranyl acetoacetate             10032-00-5
Geranyl benzoate                 94-48-4
Geranyl isovalerate              109-20-6
delta-Hexalactone                823-22-3
trans-3-Hexenal                  69112-21-6
cis-3-Hexenyl anthranilate       65405-76-7
trans-2-Hexenyl propionate       53398-80-4
5-(cis-3-Hexenyl) dihydro-5-     70851-61-5
methyl-2(3H)furanone
Hexyl 2-formate                  39251-86-0
Hexyl crotonate                  19089-92-0
Hexyl formate                    629-33-4
Isoamyl 3-(2-furyl)propionate    7779-67-1
Isoamyl pyruvate                 7779-72-8
Isobutyl furylpropionate         105-01-1
Isohexenyl cyclohexenyl          37677-14-8
carboxaldehyde
p-Isopropyl phenylacetaldehyde   4395-92-0
Linalyl cinnamate                78-37-5
Linalyl formate                  115-99-1
Linalyl isovalerate              1118-27-0
Linalyl phenylacetate            7143-69-3
Maltol isobutyrate               65416-14-0
Methyl 2-methylpentanoate        2177-77-7
Methyl 3-hydroxyhexanoate        21188-58-9
Methyl 3-nonenoate               13481-87-3
Methyl furfuryl disulfide        57500-00-2
Methyl p-tert-                   3549-23-3
butylphenylacetate
3-Methyl-1,2-cyclohexanedione    3008-43-3
alpha-Methylanisalacetone        104-27-8
2-Methylbutyl isovalerate        2445-77-4
4-Methylnonanoic acid            45019-28-1
4-Methyloctanoic acid            54947-74-9
2-Methyltetrahydrothiophen-3-    13679-85-1
one
3-(Methylthio)butanal            16630-52-7
4-(Methylthio)butanol            20582-85-8
4-Methylthio-2-butanone          34047-39-7
4-Methylthio-4-methyl-2-         23550-40-5
pentanone
Neryl butyrate                   999-40-6
Neryl formate                    2142-94-1
Neryl isovalerate                3915-83-1
Octahydrocoumarin                4430-31-3
Phenethyl 2-furoate              7149-32-8
1-Phenyl-2-pentanol              705-73-7
Phenylacetaldehyde               68345-22-2
diisobutylacetal
Phenylacetaldehyde glyceryl      29895-73-6
acetal
2-(3-Phenylpropyl)pyridine       2110-18-1
Propyl phenylacetate             4606-15-9
Pyrazineethanethiol              35250-53-4
Ethyl 2-methyl pentanoate        39255-32-8
Methyl 2,4-decadienoate          4493-42-9
alpha-Isomethyl ionone           127-51-5
5-Methyl hexanoic acid           628-46-6
Ethyl 3-methyl pentanoate        5870-68-8
Ethyl 2-methyl-3,4-              60523-21-9
pentadienoate
3-Nonen-2-one                    14309-57-0
5-Methyl-3-hexen-2-one           5166-53-0
Maltol propionate                68555-63-5
2-Methyl-3-(2-furyl) acrolein    874-66-8
Ethyl 3(2-furyl)propanoate       10031-90-0
2-Phenyl-3-(2-furyl)-propenal    57568-60-2
4-Methyl-2-pentyl-1,3-           1599-49-1
dioxolane
2-Ethyl-4,5-dimethyl oxazole     53833-30-0
Isobornyl isovalerate            7779-73-9
Theophylline-7-acetic acid       652-37-9
Ethyl trans-2-octenoate          7367-82-0
DL-Arginine                      7200-25-1
Allyl Crotonate                  20474-93-5
2-Methoxystyrene                 612-15-7
Magnesium Fumarate               7704-71-4
2-Propionylpyrrole               1073-26-3
2-methyl-1,3-dithiolane          5616-51-3
2-ethyl-5-methyl pyrazine        13360-64-0
2-methyl-3-(dimercaptomethyl)-   65505-17-1
furan
Magnesium gluconate              3632-91-5
Manganese gluconate              6485-39-8
Erythritol                       149-32-6
D-Arabinose                      28697-53-2
D-Galactose                      59-23-4
D-(+)-Mannose                    3458-28-4
Sorbitol                         50-70-4
Aspartame                        22839-47-0
Cyclamic Acid                    100-88-9
Dulcin                           150-69-6
Glucose-1-phosphate              29732-59-0
Dipotassium Salt
L-(+)-Arabinose                  87-72-9
Fructose-6-Phosphate             643-13-0
D-Maltose Monohydrate            6363-53-7
Ribose                           24259-59-4
Fructose 1,6-Diphosphate         26177-85-5
Disodium Salt
Saccharin sodium, dihydrate      6155-57-3
1,2-Benzisothiazol-3(2H)-one     6485-34-3
1,1-dioxide, calcium salt
1,2-Benzisothiazolin-3-one       10332-51-1
1,1-dioxide, potassium salt
zeranol                          26538-44-3
beta-D-fructopyranose            7660-25-5
D-fructose 1,6-bisphosphate      488-69-7
Ribose 5-phosphate               4300-28-1
Arabinose                        147-81-9
Saccharin, sodium salt hydrate   82385-42-0
Maltitol                         585-88-6
D-Fructose 1-phosphate           15978-08-2
D-Sorbitol 6-phosphate           108392-12-
alpha-D-Xylose                   31178-70-8
Inositol 1-phosphate             573-35-3

TABLE 3
Name                           CAS #
Sodium Metabisulfite           7681-57-4
sodium hydrogen phosphate      7558-79-4
Sodium Phosphate Monobasic     7558-80-7
Sodium thiosulfate             7772-98-71
Orthoboric acid                10043-35-3
Diethanolamine                 111-42-2
Benzaldehyde                   100-52-7
Sorbic acid                    110-44-1
L-(+)-Tartaric Acid            87-69-4
D-mannitol                     69-65-8
Butyl paraben                  94-26-8
Thymol                         89-83-8
Methyl salicylate              119-36-8
Citric acid                    77-92-9
Creatinine                     60-27-5
Vitamin C                      50-81-7
Benzoic Acid                   65-85-0
Methyl 4-hydroxybenzoate       99-76-3
m-Cresol                       108-39-4
p-Cresol                       106-44-5
Aspirin                        50-78-2
Phenol                         108-95-2
Sucrose                        57-50-1
Potassium citrate, monohydrate 1534146
Sodium acetate                 127-09-3
Lactic acid                    50-21-5
Propionic acid, sodium salt    65-85
Benzyl alcohol                 100-51-6
Phenethyl alcohol              60-12-8
Cholesterol                    57-88-5
D-Glucose                      50-99-7
Sorbitol                       50-70-4
Aspartame                      22839-47-0
Saccharin                      81-07-2
2,6-Di-tert-Butyl-p-Cresol     128-37-0
4-Chloro-3-methylphenol        59-50-7
glycerin                       56-81-5
Propyl paraben                 94-13-3
fumaric acid                   110-17-8
dabco                          280-57-9
p-Phenylenediamine             106-50-3
Anethole                       4180-23-8
propyl gallate                 121-79-9
L-monosodium glutamate         142-47-2
Butylated hydroxyanisole       25013-16-5
Cyclohexanol, 5-methyl-2-(1-   89-78-1
methylethyl)-,
(1alpha, 2beta, 5alpha)-
alpha-Thioglycerol             96-27-5
Sodium dehydroacetate          4418-26-2
Ethyl 4-hydroxybenzoate        120-47-8
Ethyl Vanillin                 121-32-4
Triacetin                      102-76-1
Potassium sorbate              590-00-1
Triethyl citrate               77-93-0
(S)-(+)-Arginine               74-79-3
Glycine                        56-40-6
(S)-(−)-Histidine              71-00-1
(S)-(+)-Lysine                 56-87-1
Quinone                        106-51-4
Naphthalene, 2-ethoxy-         93-18-5
Methanesulfonic Acid           75-75-2
DL-Tartaric Acid               133-37-9
Cyclamic acid                  100-88-9
(S)-(−)-Phenylalanine          63-91-2
(S)-(−)-Tyrosine               60-18-4
Carvone                        99-49-0
Ethyl butyrate                 105-54-4
6-Methyl-5-hepten-2-one        110-93-0
Ethyl acetoacetate             141-97-9
Methyl benzoate                93-58-3
Phenylacetic Acid              103-82-2
Adipic acid                    124-04-9
Ethyl benzoate                 93-89-0
Benzyl benzoate                120-51-4
Pyruvic acid                   127-17-3
Succinic acid                  110-15-6
Indole                         120-72-9
Methyl anthranilate            134-20-3
Diethyl malonate               105-53-3
Niacin                         59-67-6
Meso-inositol                  87-89-8
4-Aminobenzoic acid            150-13-0
Anisole                        100-66-3
Urea                           57-13-6
Pyrrolidine                    123-75-1
Cyclopentanone                 120-92-3
Acetic anhydride               108-24-7
Benzophenone                   119-61-9
D-(−)-Fructose                 57-48-7
D-(+)-Xylose                   58-86-6
o-Methoxybenzoic Acid          579-75-9
linalool                       78-70-6
ethyl isovalerate              108-64-5
1,1′-Azobisformamide           123-77-3
6-Methylcoumarin               92-48-8
acetoin                        513-86-0
alpha-Phellandrene             99-83-2
Cymene                         99-87-6
Dimethyl Succinate             106-65-0
p-Anisaldehyde                 123-11-5
Phenyl ether                   101-84-8
Tetrahydro-2-furanmethanol     97-99-4
Valeric Acid                   109-52-4
3,4-xylenol                    95-65-8
1,1-diethoxyethane             105-57-7
ethyl butyraldehyde            97-96-1
Ethyl crotonate                623-70-1
ethyl isobutyrate              97-62-1
methyl isovalerate             556-24-1
methyl propionate              554-12-1
methyl valeraldehyde           123-15-9
4-(2,6,6-Trimethyl-2-          127-41-3
cyclohexen-1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-          14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Maleic acid                    110-16-7
3-Methylbutanoic acid          503-74-2
L-Glutamic Acid                56-86-0
D-limonene                     5989-27-5
1-Phenyl-1-propanol            93-54-9
2′-Hydroxyacetophenone         118-93-4
2,4-Dihydroxybenzoic Acid      89-86-1
2-Phenyl-1-propanol            1123-85-9
3-Phenylpropionic Acid         501-52-0
4-Ethoxyphenol                 622-62-8
Alpha-Terpineol                98-55-5
Benzaldehyde Dimethylacetal    1125-88-8
Benzyl Ether                   103-50-4
Benzyl Formate                 104-57-4
Benzyl Salicylate              118-58-1
Cinnamyl Alcohol               104-54-1
D-(+)-Glucono-1,5-lactone      4253-68-3
D-Isoascorbic Acid             89-65-6
2,3-Naphthalenediol            92-44-4
Diethyl Succinate              123-25-1
Ethyl 2-Aminobenzoate          87-25-2
Ethyl Cinnamate                103-36-6
Ethyl Phenylacetate            101-97-3
Ethyl Salicylate               118-61-6
gamma-Valerolactone            108-29-2
Hydroquinone Dimethyl Ether    150-78-7
Isocaproic Acid                646-07-1
Isoeugenol                     97-54-1
Isopropyl Benzoate             939-48-0
L-(+)-Isoleucine               73-32-5
L-Malic acid                   97-67-6
L-2-Aminopropionic Acid        56-41-7
L-Carnitine                    541-15-1
L-Glutamine                    56-85-9
L-Hydroxyproline               51-35-4
L-Proline                      147-85-3
L-Serine                       56-45-1
L-Threonine                    72-19-5
L-Valine                       72-18-4
Phenoxyacetic Acid             122-59-8
Veratrole                      91-16-7
2-Ethylbutyric acid            88-09-5
2-Methylpyrazine               109-08-0
o-methoxybenzaldehyde          135-02-4
L-Leucine                      61-90-5
L-Asparagine                   70-47-3
propiophenone                  93-55-0
5-isopropyl-2-methyl-phenol    499-75-2
Xylitol                        87-99-0
ethyl 4-oxopentanoate          539-88-8
methyl cinnamate               103-26-4
cumic alcohol                  536-60-7
methyl 2-naphthyl ketone       93-08-3
1-methyl-4-(1-methylethyl)-    99-85-4
1,4-Cyclohexadiene
en-ethylene diamine
Caffeine                       58-08-2
5-methylfurfural               620-02-0
furfuryl acetate               623-17-6
terpinen-4-ol                  10482-56-1
phenylethanal                  122-78-1
4′-Methoxyacetophenone         100-06-1
D-Fenchone                     4695-62-9
1-Methoxy-4-methylbenzene      104-93-8
o-methylanisole                578-58-5
Acetylacetaldehyde dimethyl    5436-21-5
acetal
p-methylacetophenone           122-00-9
Methyl phenylacetate           101-41-7
4-Ethoxybenzaldehyde           10031-82-0
p-tolyl acetate                140-39-6
2,6-Dimethoxyphenol            91-10-1
Methyl 2-methoxybenzoate       606-45-1
alpha-methylcinnamaldehyde     101-39-3
2-methoxycinnamaldehyde        60125-24-8
Potassium bicarbonate          298-14-6
piperonyl acetate              326-61-4
2,3-hexanedione                3848-24-6
furfural acetone               623-15-4
trans beta-(2-furyl)acrolein   623-30-3
carveol                        99-48-9
Methyl nicotinate              93-60-7
Ethyl benzoylacetate           94-02-0
Methyl 4-methoxybenzoate       121-98-2
Levulinic acid                 123-76-2
m-Dimethoxybenzene             151-10-0
2-acetylpyridine               1122-62-9
tetramethyl-pyrazine           1124-11-4
2,3-dimethyl-pyrazine          5910-89-4
trimethyl-pyrazine             14667-55-1
2-ethyl-3-methyl-pyrazine      15707-23-0
5-Methyl-3H-furan-2-one        591-12-8
2-Methoxy-4-methylphenol       93-51-6
piperazine                     110-85-0
2-Methoxy-4-propylphenol       2785-87-7
Naphthalene, 2-(2-             2173-57-1
methylpropoxy)-
2-Acetyl-1-methylpyrrole       932-16-1
3,3-Dimethylacrylic acid       541-47-9
Ethyl sorbate                  2396-84-1
4-(4-Hydroxyphenyl)-2-butanone 5471-51-2
4-Methoxyphenylacetone         122-84-9
(−)-Myrtenal                   564-94-3
3-Phenylpropionaldehyde        104-53-0
1-Phenylethyl propionate       120-45-6
2-Methyltetrahydrofuran-3-one  3188-00-9
Cinnamyl acetate               103-54-8
Styrallyl acetate              93-92-5
Ethyl 4-methoxybenzoate        94-30-4
Benzyl propionate              122-63-4
Phenylpyruvate                 156-06-9
furaneol                       3658-77-3
methyl 2-methylbutanoate       868-57-5
Benzeneacetaldehyde, alpha-    93-53-8
methyl-
Dimethyl anthranilate          85-91-6
1,1-Dimethoxy-2-phenylpropane  90-87-9
4-hexanolide                   695-06-7
Dimethylbenzylcarbinyl acetate 151-05-3
Benzyl isobutyrate             103-28-6
Acetyl isoeugenol              93-29-8
2-Acetyl-5-methyl furan        1193-79-9
Alpha-methyl-p-                103-95-7
isopropylphenylpropanaldehyde
Benzylcarbinyl formate         104-62-1
p-Cresyl alpha-toluate         101-94-0
Potassium bisulfate            7646-93-7
Potassium carbonate            584-08-7
Potassium chloride             7447-40-7
Potassium hydroxide            1310-58-3
Ethyl tiglate                  5837-78-5
Nerol oxide                    1786-08-9
DL-Tetrohydrofurfuryl          637-65-0
propionate
Benzaldehyde propylene glycol  2568-25-4
acetal
2-Methyl-3-(2-furyl) acrolein  874-66-8
vanillin                       121-33-5
Cholic acid                    81-25-4
R-Carvone                      6485-40-1
Potassium nitrate              7757-79-1
Potassium permanganate         7722-64-7
Potassium persulfate           7727-21-1
Potassium phosphate, dibasic   2139900
Potassium Phosphate Monobasic  7778-77-0
Potassium sulfate              7778-80-5
Sodium bicarbonate             144-55-8
Sodium bisulfite               7631-90-5
Sodium carbonate               497-19-8
Sodium chloride                7647-14-5
Sodium dithionite              7775-14-6
Sodium hydroxide               1310-73-2
Sodium nitrite                 7632-00-0
Sodium Pyrophosphate           7722-88-5
Sodium sulfate                 7757-82-6
Sodium sulfite                 7757-83-7
Sodium thiocyanate             540-72-7
Calcium Carbonate              471-34-1
Calcium chloride               10043-52-4
Calcium gluconate              299-28-5
Calcium hydroxide              1305-62-0
Calcium phosphate, dibasic     7757-93-9
Calcium sulfate                7778-18-9
N-Methyl-D-glucamine           6284-40-8
Calcium oxide                  1305-78-8
Calcium Phosphate Monobasic    7758-23-8
Magnesium chloride hexahydrate 7791-18-6
Magnesium sulfate              7487-88-9
Magnesium Sulfate Heptahydrate 10034-99-8
Aluminum chloride hexahydrate  7784-13-6
aluminum nitrate nonahydrate   7784-27-2
Aluminum potassium sulfate,    7784-24-9
dodecahydrate
Aluminum sulfate,              7784-31-8
octadecahydrate
(S)-(−)-Cysteine               52-90-4
p-Toluenesulfonic Acid         104-15-4
Potassium bitartrate           868-14-4
DL-aspartic acid               617-45-8
p-Dimethylaminobenzaldehyde    100-10-7
Sodium salicylate              54-21-7
Benzoin                        119-53-9
Sodium dodecyl sulfate         151-21-3
L-Menthol                      2216-51-5
Tiron                          149-45-1
Riboflavin                     83-88-5
Sodium Acetate Trihydrate      6131-90-4
Disodium Succinate Hexahydrate 6106-21-4
Disodium                       6381-92-6
ethylenediaminetetraacetate
dihydrate
sodium citrate, dihydrate      1545801
Sodium potassium tartrate,     6381-59-5
tetrahydrate
L-(+)-Arginine                 1119-34-2
monohydrochloride
Ethylenediamine                333-18-6
dihydrochloride
Sodium formate                 141-53-7
Sodium acetate                 127-09-3
Potassium acetate              127-08-2
Ammonium citrate               3012-65-5
Ammonium bicarbonate           1066-33-7
Ammonium chloride              12125-02-9
Ammonium nitrate               6484-52-2
Ammonium persulfate            7727-54-0
Ammonium sulfate               7783-20-2
Zinc chloride                  7646-85-7
Sulfuric acid, zinc salt       7446-20-0
(1:1), heptahydrate
Sodium Tripolyphosphate        7758-29-4
ammonium benzoate              1863-63-4
ammonium bisulfite             10192-30-0
1,5-Naphthalenedisulfonic Acid 1655-29-4
Disodium Salt
4-Hydroxybenzoic Acid          99-96-7
Diphenylacetic Acid            117-34-0
Glutaric Acid                  110-94-1
L-(−)-Fucose                   2438-80-4
L-Cysteine Hydrochloride       52-89-1
L-Histidine Hydrochloride      1880304
Monohydrate
o-Toluic Acid                  118-90-1
Pivalic Acid                   75-98-9
Pyruvic Acid Sodium Salt       113-24-6
Potassium bromide              2139626
Sodium Dithionate Dihydrate    7631-94-9
Sodium Malonate                141-95-7
Trisodium Citrate              68-04-2
Potassium Sodium Tartrate      304-59-6
Potassium Citrate              866-84-2
D-Maltose Monohydrate          6363-53-7
Cyclohexaamylose               10016-20-3
Dodecyl sulfate, lithium salt  2044-56-6
Manganese chloride             2145076
methyl-urea                    598-50-5
beta-Cyclodextrin              7585-39-9
Triphosphoric acid,            13845-36-8
pentapotassium salt
Glycine ethyl ester            623-33-6
hydrochloride
L-Histidine methyl ester       7389-87-9
dihydrochloride
L-Leucine methyl ester         7517-19-3
hydrochloride
D-Lysine hydrochloride         7274-88-6
2 -Naphthalenesulfonic acid    532-02-5
sodium salt
calcium nitrate tetrahydrate   13477-34-4
Vitamin B1                     59-43-8
Zinc Acetate Dihydrate         5970-45-6
Potassium fluoride             7789-23-3
Potassium iodate               2139718
Potassium iodide               7681-11-0
Potassium thiocyanate          333-20-0
Sodium bromide                 7647-15-6
Sodium fluoride                7681-49-4
Sodium iodide                  7681-82-5
Sodium nitrate                 7631-99-4
Calcium acetate                5743-26-0
Trichloroacetic acid           76-03-9
Ammonium acetate               631-61-8
Ammonium fluoride              12125-01-8
DL-malic acid                  617-48-1
t-Butyl Alcohol                75-65-0
beta-Alanine                   107-95-9
(S)-(−)-Tryptophan             73-22-3
Malonic acid                   141-82-2
Phenethylamine                 64-04-0
Salicylylaldehyde              90-02-8
Sodium benzoate                532-32-1
Mandelic acid                  90-64-2
Calcium pantothenate           137-08-6
Chloroacetic Acid              79-11-8
Ethanol Amine                  141-43-5
Salicylic acid                 69-72-7
Saccharin sodium               128-44-9
Thiamine hydrochloride         67-03-8
2,2′-Oxybisethanol             111-46-6
Resorcinol                     108-46-3
2-Amino-2-(hydroxymethyl)-1,3- 77-86-1
propanediol
2,5-Dimethylphenol             95-87-4
Ammonium Phosphate Monobasic   7722-76-1
1,3-Butanediol                 107-88-0
Glycolic Acid                  79-14-1
Sodium Gluconate               527-07-1
Terephthalic Acid              100-21-0
L-Ascorbic Acid Sodium Salt    134-03-2
3-Acetyl-6-methyl-2,4-         520-45-6
pyrandione
Calcium Acetate                62-54-4
Nicotinamide                   98-92-0
1-Hydroxy-2-naphthoic Acid     86-48-6
2-Isopropylphenol              88-69-7
4-Aminosalicylic Acid          65-49-6
Calcium Glycerophosphate       27214-00-2
Erythorbic Acid Sodium Salt    7378-23-6
Gluconic Acid Potassium Salt   299-27-4
Orotic Acid                    65-86-1
p-Anise Alcohol                105-13-5
Potassium Benzoate             582-25-2
Taurine                        107-35-7
Thiamine Nitrate               532-43-4
3,3,5-Trimethyl-1-cyclohexanol 116-02-9
tert-Butylhydroquinone         1948-33-0
Sulfosalicylic acid            97-05-2
Gallic acid                    149-91-7
L-borneol                      464-45-9
Isoborneol                     124-76-5
2,5-Dihydroxybenzoic acid,     490-79-9
Gentisic acid
5-hydroxy-6-methyl-3,4-        65-23-6
pyridinedimethanol
Naphthalene-2-sulfonic acid    120-18-3
Ethanesulfonic acid, 2-        1562-00-1
hydroxy-, monosodium salt
Pamoic acid                    130-85-8
2,4-Dimethylphenol             105-67-9
3,5-Dihydroxyacetophenone      51863-60-6
Eugenol                        97-53-0
n-Butyric Acid                 107-92-6
Hydroquinone                   123-31-9
Propionic Acid                 79-09-4
meta-Phenylenediamine          108-45-2
Oxalic Acid                    144-62-7
n-Hexanoic Acid                142-62-1
2-Furancarboxylic Acid         88-14-2
4′-Nitroacetanilide            104-04-1
D-(−)-Tartaric Acid            147-71-7
p-Acetamidobenzoic Acid        556-08-1
Galactaric acid                526-99-8
D-glucuronate                  1700908
Lactobionic acid               96-82-2
p-Formylacetanilide            122-85-0
2-Mercaptobenzoic acid         147-93-3
Propanoic acid, 2-hydroxy-,    28305-25-1
calcium salt (2:1), (S)-
D(+)-10-Camphorsulfonic acid   3144-16-9
3-Cyclopentylpropionic acid    140-77-2
1R-(−)-Camphorsulfonic acid    35963-20-3
DL-Lysine                      70-54-2
Cinnamic acid                  621-82-9
Triethanolamine                102-71-6
Acetic Acid                    64-19-7
Dichloroacetic Acid            79-43-6
Diethylamine                   109-89-7
Diethylaminoethanol            100-37-8
N-(2-Hydroxyethyl)Morpholine   622-40-2
Octanoic Acid                  124-07-2
isobutyric acid                79-31-2
Anisic Acid                    100-09-4
Betaine                        107-43-7
Enanthoic Acid                 111-14-8
Hippuric Acid                  495-69-2
Tiglic Acid                    80-59-1
Cyclohexanecarboxylic acid     98-89-5
m-Methoxybenzoic acid          586-38-9
D-(+)-Camphoric acid           124-83-4
N-(2-Hydroxyethyl)pyrrolidine  2955-88-6
Sodium Metabisulfite           7681-57-4
sodium hydrogen phosphate      7558-79-4
Sodium Phosphate Monobasic     7558-80-7
Sodium thiosulfate             7772-98-71
Orthoboric acid                10043-35-3
Diethanolamine                 111-42-2
Benzaldehyde                   100-52-7
Sorbic acid                    110-44-1
L-(+)-Tartaric Acid            87-69-4
D-mannitol                     69-65-8
Butyl paraben                  94-26-8
Thymol                         89-83-8
Methyl salicylate              119-36-8
Citric acid                    77-92-9
Creatinine                     60-27-5
Vitamin C                      50-81-7
Benzoic Acid                   65-85-0
Methyl 4-hydroxybenzoate       99-76-3
m-Cresol                       108-39-4
p-Cresol                       106-44-5
Aspirin                        50-78-2
Phenol                         108-95-2
Sucrose                        57-50-1
Potassium citrate, monohydrate 1534146
Sodium acetate                 127-09-3
Lactic acid                    50-21-5
Propionic acid, sodium salt    65-85
Benzyl alcohol                 100-51-6
Phenethyl alcohol              60-12-8
Cholesterol                    57-88-5
D-Glucose                      50-99-7
Sorbitol                       50-70-4
Aspartame                      22839-47-0
Saccharin                      81-07-2
2,6-Di-tert-Butyl-p-Cresol     128-37-0
4-Chloro-3-methylphenol        59-50-7
glycerin                       56-81-5
Propyl paraben                 94-13-3
fumaric acid                   110-17-8
dabco                          280-57-9
p-Phenylenediamine             106-50-3
Anethole                       4180-23-8
propyl gallate                 121-79-9
L-monosodium glutamate         142-47-2
Butylated hydroxyanisole       25013-16-5
Cyclohexanol, 5-methyl-2-(1-   89-78-1
methylethyl)-,
(1alpha,2beta,5alpha)-
alpha-Thioglycerol             96-27-5
Sodium dehydroacetate          4418-26-2
Ethyl 4-hydroxybenzoate        120-47-8
Ethyl Vanillin                 121-32-4
Triacetin                      102-76-1
Potassium sorbate              590-00-1
Triethyl citrate               77-93-0
(S)-(+)-Arginine               74-79-3
Glycine                        56-40-6
(S)-(−)-Histidine              71-00-1
(S)-(+)-Lysine                 56-87-1
Quinone                        106-51-4
Naphthalene, 2-ethoxy-         93-18-5
Methanesulfonic Acid           75-75-2
DL-Tartaric Acid               133-37-9
Cyclamic acid                  100-88-9
(S)-(−)-Phenylalanine          63-91-2
(S)-(−)-Tyrosine               60-18-4
Carvone                        99-49-0
Ethyl butyrate                 105-54-4
6-Methyl-5-hepten-2-one        110-93-0
Ethyl acetoacetate             141-97-9
Methyl benzoate                93-58-3
Phenylacetic Acid              103-82-2
Adipic acid                    124-04-9
Ethyl benzoate                 93-89-0
Benzyl benzoate                120-51-4
Pyruvic acid                   127-17-3
Succinic acid                  110-15-6
Indole                         120-72-9
Methyl anthranilate            134-20-3
Diethyl malonate               105-53-3
Niacin                         59-67-6
Meso-inositol                  87-89-8
4-Aminobenzoic acid            150-13-0
Anisole                        100-66-3
Urea                           57-13-6
Pyrrolidine                    123-75-1
Cyclopentanone                 120-92-3
Acetic anhydride               108-24-7
Benzophenone                   119-61-9
D-(−)-Fructose                 57-48-7
D-(+)-Xylose                   58-86-6
o-Methoxybenzoic Acid          579-75-9
linalool                       78-70-6
ethyl isovalerate              108-64-5
1,1′-Azobisformamide           123-77-3
6-Methylcoumarin               92-48-8
acetoin                        513-86-0
alpha-Phellandrene             99-83-2
Cymene                         99-87-6
Dimethyl Succinate             106-65-0
p-Anisaldehyde                 123-11-5
Phenyl ether                   101-84-8
Tetrahydro-2-furanmethanol     97-99-4
Valeric Acid                   109-52-4
3,4-xylenol                    95-65-8
1,1-diethoxyethane             105-57-7
ethyl butyraldehyde            97-96-1
Ethyl crotonate                623-70-1
ethyl isobutyrate              97-62-1
methyl isovalerate             556-24-1
methyl propionate              554-12-1
methyl valeraldehyde           123-15-9
4-(2,6,6-Trimethyl-2-          127-41-3
cyclohexen-1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-          14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Maleic acid                    110-16-7
3-Methylbutanoic acid          503-74-2
L-Glutamic Acid                56-86-0
D-limonene                     5989-27-5
1-Phenyl-1-propanol            93-54-9
2′-Hydroxyacetophenone         118-93-4
2,4-Dihydroxybenzoic Acid      89-86-1
2-Phenyl-1-propanol            1123-85-9
3-Phenylpropionic Acid         501-52-0
4-Ethoxyphenol                 622-62-8
Alpha-Terpineol                98-55-5
Benzaldehyde Dimethylacetal    1125-88-8
Benzyl Ether                   103-50-4
Benzyl Formate                 104-57-4
Benzyl Salicylate              118-58-1
Cinnamyl Alcohol               104-54-1
D-(+)-Glucono-1,5-lactone      4253-68-3
D-Isoascorbic Acid             89-65-6
2,3-Naphthalenediol            92-44-4
Diethyl Succinate              123-25-1
Ethyl 2-Aminobenzoate          87-25-2
Ethyl Cinnamate                103-36-6
Ethyl Phenylacetate            101-97-3
Ethyl Salicylate               118-61-6
gamma-Valerolactone            108-29-2
Hydroquinone Dimethyl Ether    150-78-7
Isocaproic Acid                646-07-1
Isoeugenol                     97-54-1
Isopropyl Benzoate             939-48-0
L-(+)-Isoleucine               73-32-5
L-Malic acid                   97-67-6
L-2-Aminopropionic Acid        56-41-7
L-Carnitine                    541-15-1
L-Glutamine                    56-85-9
L-Hydroxyproline               51-35-4
L-Proline                      147-85-3
L-Serine                       56-45-1
L-Threonine                    72-19-5
L-Valine                       72-18-4
Phenoxyacetic Acid             122-59-8
Veratrole                      91-16-7
2-Ethylbutyric acid            88-09-5
2-Methylpyrazine               109-08-0
o-methoxybenzaldehyde          135-02-4
L-Leucine                      61-90-5
L-Asparagine                   70-47-3
propiophenone                  93-55-0
5-isopropyl-2-methyl-phenol    499-75-2
Xylitol                        87-99-0
ethyl 4-oxopentanoate          539-88-8
methyl cinnamate               103-26-4
cumic alcohol                  536-60-7
methyl 2-naphthyl ketone       93-08-3
1-methyl-4-(1-methylethyl)-    99-85-4
1,4-Cyclohexadiene
en - ethylene diamine
Caffeine                       58-08-2
5-methylfurfural               620-02-0
furfuryl acetate               623-17-6
terpinen-4-ol                  10482-56-1
phenylethanal                  122-78-1
4′-Methoxyacetophenone         100-06-1
D-Fenchone                     4695-62-9
1-Methoxy-4-methylbenzene      104-93-8
o-methylanisole                578-58-5
Acetylacetaldehyde dimethyl    5436-21-5
acetal
p-methylacetophenone           122-00-9
Methyl phenylacetate           101-41-7
4-Ethoxybenzaldehyde           10031-82-0
p-tolyl acetate                140-39-6
2,6-Dimethoxyphenol            91-10-1
Methyl 2-methoxybenzoate       606-45-1
alpha-methylcinnamaldehyde     101-39-3
2-methoxycinnamaldehyde        60125-24-8
Potassium bicarbonate          298-14-6
piperonyl acetate              326-61-4
2,3-hexanedione                3848-24-6
furfural acetone               623-15-4
trans beta-(2-furyl)acrolein   623-30-3
carveol                        99-48-9
Methyl nicotinate              93-60-7
Ethyl benzoylacetate           94-02-0
Methyl 4-methoxybenzoate       121-98-2
Levulinic acid                 123-76-2
m-Dimethoxybenzene             151-10-0
2-acetylpyridine               1122-62-9
tetramethyl-pyrazine           1124-11-4
2,3-dimethyl-pyrazine          5910-89-4
trimethyl-pyrazine             14667-55-1
2-ethyl-3-methyl-pyrazine      15707-23-0
5-Methyl-3H-furan-2-one        591-12-8
2-Methoxy-4-methylphenol       93-51-6
piperazine                     110-85-0
2-Methoxy-4-propylphenol       2785-87-7
Naphthalene,2-(2-              2173-57-1
methylpropoxy)-
2-Acetyl-1-methylpyrrole       932-16-1
3,3-Dimethylacrylic acid       541-47-9
Ethyl sorbate                  2396-84-1
4-(4-Hydroxyphenyl)-2-butanone 5471-51-2
4-Methoxyphenylacetone         122-84-9
(−)-Myrtenal                   564-94-3
3-Phenylpropionaldehyde        104-53-0
1-Phenylethyl propionate       120-45-6
2-Methyltetrahydrofuran-3-one  3188-00-9
Cinnamyl acetate               103-54-8
Styrallyl acetate              93-92-5
Ethyl 4-methoxybenzoate        94-30-4
Benzyl propionate              122-63-4
Phenylpyruvate                 156-06-9
furaneol                       3658-77-3
methyl 2-methylbutanoate       868-57-5
Benzeneacetaldehyde, alpha-    93-53-8
methyl-
Dimethyl anthranilate          85-91-6
1,1-Dimethoxy-2-phenylpropane  90-87-9
4-hexanolide                   695-06-7
Dimethylbenzylcarbinyl acetate 151-05-3
Benzyl isobutyrate             103-28-6
Acetyl isoeugenol              93-29-8
2-Acetyl-5-methyl furan        1193-79-9
Alpha-methyl-p                 103-95-7
isopropylphenylpropanaldehyde
Benzylcarbinyl formate         104-62-1
p-Cresyl alpha-toluate         101-94-0
Potassium bisulfate            7646-93-7
Potassium carbonate            584-08-7
Potassium chloride             7447-40-7
Potassium hydroxide            1310-58-3
Ethyl tiglate                  5837-78-5
Nerol oxide                    1786-08-9
DL-Tetrohydrofurfuryl          637-65-0
propionate
Benzaldehyde propylene glycol  2568-25-4
acetal
2-Methyl-3-(2-furyl) acrolein  874-66-8
vanillin                       121-33-5
Cholic acid                    81-25-4
R-Carvone                      6485-40-1
Potassium nitrate              7757-79-1
Potassium permanganate         7722-64-7
Potassium persulfate           7727-21-1
Potassium phosphate, dibasic   2139900
Potassium Phosphate Monobasic  7778-77-0
Potassium sulfate              7778-80-5
Sodium bicarbonate             144-55-8
Sodium bisulfite               7631-90-5
Sodium carbonate               497-19-8
Sodium chloride                7647-14-5
Sodium dithionite              7775-14-6
Sodium hydroxide               1310-73-2
Sodium nitrite                 7632-00-0
Sodium Pyrophosphate           7722-88-5
Sodium sulfate                 7757-82-6
Sodium sulfite                 7757-83-7
Sodium thiocyanate             540-72-7
Calcium Carbonate              471-34-1
Calcium chloride               10043-52-4
Calcium gluconate              299-28-5
Calcium hydroxide              1305-62-0
Calcium phosphate, dibasic     7757-93-9
Calcium sulfate                7778-18-9
N-Methyl-D-glucamine           6284-40-8
Calcium oxide                  1305-78-8
Calcium Phosphate Monobasic    7758-23-8
Magnesium chloride hexahydrate 7791-18-6
Magnesium sulfate              7487-88-9
Magnesium Sulfate Heptahydrate 10034-99-8
Aluminum chloride hexahydrate  7784-13-6
aluminum nitrate nonahydrate   7784-27-2
Aluminum potassium sulfate,    7784-24-9
dodecahydrate
Aluminum sulfate,              7784-31-8
octadecahydrate
(S)-(−)-Cysteine               52-90-4
p-Toluenesulfonic Acid         104-15-4
Potassium bitartrate           868-14-4
DL-aspartic acid               617-45-8
p-Dimethylaminobenzaldehyde    100-10-7
Sodium salicylate              54-21-7
Benzoin                        119-53-9
Sodium dodecyl sulfate         151-21-3
L-Menthol                      2216-51-5
Tiron                          149-45-1
Riboflavin                     83-88-5
Sodium Acetate Trihydrate      6131-90-4
Disodium Succinate Hexahydrate 6106-21-4
Disodium                       6381-92-6
ethylenediaminetetraacetate
dihydrate
sodium citrate, dihydrate      1545801
Sodium potassium tartrate,     6381-59-5
tetrahydrate
L-(+)-Arginine                 1119-34-2
monohydrochloride
Ethylenediamine                333-18-6
dihydrochloride
Sodium formate                 141-53-7
Sodium acetate                 127-09-3
Potassium acetate              127-08-2
Ammonium citrate               3012-65-5
Ammonium bicarbonate           1066-33-7
Ammonium chloride              12125-02-9
Ammonium nitrate               6484-52-2
Ammonium persulfate            7727-54-0
Ammonium sulfate               7783-20-2
Zinc chloride                  7646-85-7
Sulfuric acid, zinc salt       7446-20-0
(1:1), heptahydrate
Sodium Tripolyphosphate        7758-29-4
ammonium benzoate              1863-63-4
ammonium bisulfite             10192-30-0
1,5-Naphthalenedisulfonic Acid 1655-29-4
Disodium Salt
4-Hydroxybenzoic Acid          99-96-7
Diphenylacetic Acid            117-34-0
Glutaric Acid                  110-94-1
L-(−)-Fucose                   2438-80-4
L-Cysteine Hydrochloride       52-89-1
L-Histidine Hydrochloride      1880304
Monohydrate
o-Toluic Acid                  118-90-1
Pivalic Acid                   75-98-9
Pyruvic Acid Sodium Salt       113-24-6
Potassium bromide              2139626
Sodium Dithionate Dihydrate    7631-94-9
Sodium Malonate                141-95-7
Trisodium Citrate              68-04-2
Potassium Sodium Tartrate      304-59-6
Potassium Citrate              866-84-2
D-Maltose Monohydrate          6363-53-7
Cyclohexaamylose               10016-20-3
Dodecyl sulfate, lithium salt  2044-56-6
Manganese chloride             2145076
methyl-urea                    598-50-5
beta-Cyclodextrin              7585-39-9
Triphosphoric acid,            13845-36-8
pentapotassium salt
Glycine ethyl ester            623-33-6
hydrochloride
L-Histidine methyl ester       7389-87-9
dihydrochloride
L-Leucine methyl ester         7517-19-3
hydrochloride
D-Lysine hydrochloride         7274-88-6
2-Naphthalenesulfonic acid     532-02-5
sodium salt
calcium nitrate tetrahydrate   13477-34-4
Vitamin B1                     59-43-8
Zinc Acetate Dihydrate         5970-45-6
Potassium fluoride             7789-23-3
Potassium iodate               2139718
Potassium iodide               7681-11-0
Potassium thiocyanate          333-20-0
Sodium bromide                 7647-15-6
Sodium fluoride                7681-49-4
Sodium iodide                  7681-82-5
Sodium nitrate                 7631-99-4
Calcium acetate                5743-26-0
Trichloroacetic acid           76-03-9
Ammonium acetate               631-61-8
Ammonium fluoride              12125-01-8
DL-malic acid                  617-48-1
t-Butyl Alcohol                75-65-0
beta-Alanine                   107-95-9
(S)-(−)-Tryptophan             73-22-3
Malonic acid                   141-82-2
Phenethylamine                 64-04-0
Salicylylaldehyde              90-02-8
Sodium benzoate                532-32-1
Mandelic acid                  90-64-2
Calcium pantothenate           137-08-6
Chloroacetic Acid              79-11-8
Ethanol Amine                  141-43-5
Salicylic acid                 69-72-7
Saccharin sodium               128-44-9
Thiamine hydrochloride         67-03-8
2,2′-Oxybisethanol             111-46-6
Resorcinol                     108-46-3
2-Amino-2-(hydroxymethyl)-1,3- 77-86-1
propanediol
2,5-Dimethylphenol             95-87-4
Ammonium Phosphate Monobasic   7722-76-1
1,3-Butanediol                 107-88-0
Glycolic Acid                  79-14-1
Sodium Gluconate               527-07-1
Terephthalic Acid              100-21-0
L-Ascorbic Acid Sodium Salt    134-03-2
3-Acetyl-6-methyl-2,4-         520-45-6
pyrandione
Calcium Acetate                62-54-4
Nicotinamide                   98-92-0
1-Hydroxy-2-naphthoic Acid     86-48-6
2-Isopropylphenol              88-69-7
4-Aminosalicylic Acid          65-49-6
Calcium Glycerophosphate       27214-00-2
Erythorbic Acid Sodium Salt    7378-23-6
Gluconic Acid Potassium Salt   299-27-4
Orotic Acid                    65-86-1
p-Anise Alcohol                105-13-5
Potassium Benzoate             582-25-2
Taurine                        107-35-7
Thiamine Nitrate               532-43-4
3,3,5-Trimethyl-1-cyclohexanol 116-02-9
tert-Butylhydroquinone         1948-33-0
Sulfosalicylic acid            97-05-2
Gallic acid                    149-91-7
L-borneol                      464-45-9
Isoborneol                     124-76-5
2,5-Dihydroxybenzoic acid,     490-79-9
Gentisic acid
5-hydroxy-6-methyl-3,4-        65-23-6
pyridinedimethanol
Naphthalene-2-sulfonic acid    120-18-3
Ethanesulfonic acid, 2-        1562-00-1
hydroxy-, monosodium salt
Pamoic acid                    130-85-8
2,4-Dimethylphenol             105-67-9
3,5-Dihydroxyacetophenone      51863-60-6
Eugenol                        97-53-0
n-Butyric Acid                 107-92-6
Hydroquinone                   123-31-9
Propionic Acid                 79-09-4
meta-Phenylenediamine          108-45-2
Oxalic Acid                    144-62-7
n-Hexanoic Acid                142-62-1
2-Furancarboxylic Acid         88-14-2
4′-Nitroacetanilide            104-04-1
D-(−)-Tartaric Acid            147-71-7
p-Acetamidobenzoic Acid        556-08-1
Galactaric acid                526-99-8
D-glucuronate                  1700908
Lactobionic acid               96-82-2
p-Formylacetanilide            122-85-0
2-Mercaptobenzoic acid         147-93-3
Propanoic acid, 2-hydroxy-,    28305-25-1
calcium salt (2:1), (S)-
D(+)-10-Camphorsulfonic acid   3144-16-9
3-Cyclopentylpropionic acid    140-77-2
1R-(−)-Camphorsulfonic acid    35963-20-3
DL-Lysine                      70-54-2
Cinnamic acid                  621-82-9
Triethanolamine                102-71-6
Acetic Acid                    64-19-7
Dichloroacetic Acid            79-43-6
Diethylamine                   109-89-7
Diethylaminoethanol            100-37-8
N-(2-Hydroxyethyl)Morpholine   622-40-2
Octanoic Acid                  124-07-2
isobutyric acid                79-31-2
Anisic Acid                    100-09-4
Betaine                        107-43-7
Enanthoic Acid                 111-14-8
Hippuric Acid                  495-69-2
Tiglic Acid                    80-59-1
Cyclohexanecarboxylic acid     98-89-5
m-Methoxybenzoic acid          586-38-9
D-(+)-Camphoric acid           124-83-4
N-(2-Hydroxyethyl)pyrrolidine  2955-88-6
Sodium Metabisulfite           7681-57-4
sodium hydrogen phosphate      7558-79-4
Sodium Phosphate Monobasic     7558-80-7
Sodium thiosulfate             7772-98-71
Orthoboric acid                10043-35-3
Diethanolamine                 111-42-2
Benzaldehyde                   100-52-7
Sorbic acid                    110-44-1
L-(+)-Tartaric Acid            87-69-4
D-mannitol                     69-65-8
Butyl paraben                  94-26-8
Thymol                         89-83-8
Methyl salicylate              119-36-8
Citric acid                    77-92-9
Creatinine                     60-27-5
Vitamin C                      50-81-7
Benzoic Acid                   65-85-0
Methyl 4-hydroxybenzoate       99-76-3
m-Cresol                       108-39-4
p-Cresol                       106-44-5
Aspirin                        50-78-2
Phenol                         108-95-2
Sucrose                        57-50-1
Potassium citrate, monohydrate 1534146
Sodium acetate                 127-09-3
Lactic acid                    50-21-5
Propionic acid, sodium salt    65-85
Benzyl alcohol                 100-51-6
Phenethyl alcohol              60-12-8
Cholesterol                    57-88-5
D-Glucose                      50-99-7
Sorbitol                       50-70-4
Aspartame                      22839-47-0
Saccharin                      81-07-2
2,6-Di-tert-Butyl-p-Cresol     128-37-0
4-Chloro-3-methylphenol        59-50-7
glycerin                       56-81-5
Propyl paraben                 94-13-3
fumaric acid                   110-17-8
dabco                          280-57-9
p-Phenylenediamine             106-50-3
Anethole                       4180-23-8
propyl gallate                 121-79-9
L-monosodium glutamate         142-47-2
Butylated hydroxyanisole       25013-16-5
Cyclohexanol, 5-methyl-2-(1-   89-78-1
methylethyl)-,
(1alpha, 2beta, 5alpha)-
alpha-Thioglycerol             96-27-5
Sodium dehydroacetate          4418-26-2
Ethyl 4-hydroxybenzoate        120-47-8
Ethyl Vanillin                 121-32-4
Triacetin                      102-76-1
Potassium sorbate              590-00-1
Triethyl citrate               77-93-0
(S)-(+)-Arginine               74-79-3
Glycine                        56-40-6
(S)-(−)-Histidine              71-00-1
(S)-(+)-Lysine                 56-87-1
Quinone                        106-51-4
Naphthalene, 2-ethoxy-         93-18-5
Methanesulfonic Acid           75-75-2
DL-Tartaric Acid               133-37-9
Cyclamic acid                  100-88-9
(S)-(−)-Phenylalanine          63-91-2
(S)-(−)-Tyrosine               60-18-4
Carvone                        99-49-0
Ethyl butyrate                 105-54-4
6-Methyl-5-hepten-2-one        110-93-0
Ethyl acetoacetate             141-97-9
Methyl benzoate                93-58-3
Phenylacetic Acid              103-82-2
Adipic acid                    124-04-9
Ethyl benzoate                 93-89-0
Benzyl benzoate                120-51-4
Pyruvic acid                   127-17-3
Succinic acid                  110-15-6
Indole                         120-72-9
Methyl anthranilate            134-20-3
Diethyl malonate               105-53-3
Niacin                         59-67-6
Meso-inositol                  87-89-8
4-Aminobenzoic acid            150-13-0
Anisole                        100-66-3
Urea                           57-13-6
Pyrrolidine                    123-75-1
Cyclopentanone                 120-92-3
Acetic anhydride               108-24-7
Benzophenone                   119-61-9
D-(−)-Fructose                 57-48-7
D-(+)-Xylose                   58-86-6
o-Methoxybenzoic Acid          579-75-9
linalool                       78-70-6
ethyl isovalerate              108-64-5
1,1′-Azobisformamide           123-77-3
6-Methylcoumarin               92-48-8
acetoin                        513-86-0
alpha-Phellandrene             99-83-2
Cymene                         99-87-6
Dimethyl Succinate             106-65-0
p-Anisaldehyde                 123-11-5
Phenyl ether                   101-84-8
Tetrahydro-2-furanmethanol     97-99-4
Valeric Acid                   109-52-4
3,4-xylenol                    95-65-8
1,1-diethoxyethane             105-57-7
ethyl butyraldehyde            97-96-1
Ethyl crotonate                623-70-1
ethyl isobutyrate              97-62-1
methyl isovalerate             556-24-1
methyl propionate              554-12-1
methyl valeraldehyde           123-15-9
4-(2,6,6-Trimethyl-2-          127-41-3
cyclohexen-1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-          14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Maleic acid                    110-16-7
3-Methylbutanoic acid          503-74-2
L-Glutamic Acid                56-86-0
D-limonene                     5989-27-5
1-Phenyl-1-propanol            93-54-9
2′-Hydroxyacetophenone         118-93-4
2,4-Dihydroxybenzoic Acid      89-86-1
2-Phenyl-1-propanol            1123-85-9
3-Phenylpropionic Acid         501-52-0
4-Ethoxyphenol                 622-62-8
Alpha-Terpineol                98-55-5
Benzaldehyde Dimethylacetal    1125-88-8
Benzyl Ether                   103-50-4
Benzyl Formate                 104-57-4
Benzyl Salicylate              118-58-1
Cinnamyl Alcohol               104-54-1
D-(+)-Glucono-1,5-lactone      4253-68-3
D-Isoascorbic Acid             89-65-6
2,3-Naphthalenediol            92-44-4
Diethyl Succinate              123-25-1
Ethyl 2-Aminobenzoate          87-25-2
Ethyl Cinnamate                103-36-6
Ethyl Phenylacetate            101-97-3
Ethyl Salicylate               118-61-6
gamma-Valerolactone            108-29-2
Hydroquinone Dimethyl Ether    150-78-7
Isocaproic Acid                646-07-1
Isoeugenol                     97-54-1
Isopropyl Benzoate             939-48-0
L-(+)-Isoleucine               73-32-5
L-Malic acid                   97-67-6
L-2-Aminopropionic Acid        56-41-7
L-Carnitine                    541-15-1
L-Glutamine                    56-85-9
L-Hydroxyproline               51-35-4
L-Proline                      147-85-3
L-Serine                       56-45-1
L-Threonine                    72-19-5
L-Valine                       72-18-4
Phenoxyacetic Acid             122-59-8
Veratrole                      91-16-7
2-Ethylbutyric acid            88-09-5
2-Methylpyrazine               109-08-0
o-methoxybenzaldehyde          135-02-4
L-Leucine                      61-90-5
L-Asparagine                   70-47-3
propiophenone                  93-55-0
5-isopropyl-2-methyl-phenol    499-75-2
Xylitol                        87-99-0
ethyl 4-oxopentanoate          539-88-8
methyl cinnamate               103-26-4
cumic alcohol                  536-60-7
methyl 2-naphthyl ketone       93-08-3
1-methyl-4-(1-methylethyl)-    99-85-4
1,4-Cyclohexadiene
en-ethylene diamine
Caffeine                       58-08-2
5-methylfurfural               620-02-0
furfuryl acetate               623-17-6
terpinen-4-ol                  10482-56-1
phenylethanal                  122-78-1
4′-Methoxyacetophenone         100-06-1
D-Fenchone                     4695-62-9
1-Methoxy-4-methylbenzene      104-93-8
o-methylanisole                578-58-5
Acetylacetaldehyde dimethyl    5436-21-5
acetal
p-methylacetophenone           122-00-9
Methyl phenylacetate           101-41-7
4-Ethoxybenzaldehyde           10031-82-0
p-tolyl acetate                140-39-6
2,6-Dimethoxyphenol            91-10-1
Methyl 2-methoxybenzoate       606-45-1
alpha-methylcinnamaldehyde     101-39-3
2-methoxycinnamaldehyde        60125-24-8
Potassium bicarbonate          298-14-6
piperonyl acetate              326-61-4
2,3-hexanedione                3848-24-6
furfural acetone               623-15-4
trans beta-(2-furyl)acrolein   623-30-3
carveol                        99-48-9
Methyl nicotinate              93-60-7
Ethyl benzoylacetate           94-02-0
Methyl 4-methoxybenzoate       121-98-2
Levulinic acid                 123-76-2
m-Dimethoxybenzene             151-10-0
2-acetylpyridine               1122-62-9
tetramethyl-pyrazine           1124-11-4
2,3-dimethyl-pyrazine          5910-89-4
trimethyl-pyrazine             14667-55-1
2-ethyl-3-methyl-pyrazine      15707-23-0
5-Methyl-3H-furan-2-one        591-12-8
2-Methoxy-4-methylphenol       93-51-6
piperazine                     110-85-0
2-Methoxy-4-propylphenol       2785-87-7
Naphthalene, 2-(2-             2173-57-1
methylpropoxy)-
2-Acetyl-1-methylpyrrole       932-16-1
3,3-Dimethylacrylic acid       541-47-9
Ethyl sorbate                  2396-84-1
4-(4-Hydroxyphenyl)-2-butanone 5471-51-2
4-Methoxyphenylacetone         122-84-9
(−)-Myrtenal                   564-94-3
3-Phenylpropionaldehyde        104-53-0
1-Phenylethyl propionate       120-45-6
2-Methyltetrahydrofuran-3-one  3188-00-9
Cinnamyl acetate               103-54-8
Styrallyl acetate              93-92-5
Ethyl 4-methoxybenzoate        94-30-4
Benzyl propionate              122-63-4
Phenylpyruvate                 156-06-9
furaneol                       3658-77-3
methyl 2-methylbutanoate       868-57-5
Benzeneacetaldehyde, alpha-    93-53-8
methyl-
Dimethyl anthranilate          85-91-6
1,1-Dimethoxy-2-phenylpropane  90-87-9
4-hexanolide                   695-06-7
Dimethylbenzylcarbinyl acetate 151-05-3
Benzyl isobutyrate             103-28-6
Acetyl isoeugenol              93-29-8
2-Acetyl-5-methyl furan        1193-79-9
Alpha-methyl-p-                103-95-7
isopropylphenylpropanaldehyde
Benzylcarbinyl formate         104-62-1
p-Cresyl alpha-toluate         101-94-0
Potassium bisulfate            7646-93-7
Potassium carbonate            584-08-7
Potassium chloride             7447-40-7
Potassium hydroxide            1310-58-3
Ethyl tiglate                  5837-78-5
Nerol oxide                    1786-08-9
DL-Tetrohydrofurfuryl          637-65-0
propionate
Benzaldehyde propylene glycol  2568-25-4
acetal
2-Methyl-3-(2-furyl) acrolein  874-66-8
vanillin                       121-33-5
Cholic acid                    81-25-4
R-Carvone                      6485-40-1
Potassium nitrate              7757-79-1
Potassium permanganate         7722-64-7
Potassium persulfate           7727-21-1
Potassium phosphate, dibasic   2139900
Potassium Phosphate Monobasic  7778-77-0
Potassium sulfate              7778-80-5
Sodium bicarbonate             144-55-8
Sodium bisulfite               7631-90-5
Sodium carbonate               497-19-8
Sodium chloride                7647-14-5
Sodium dithionite              7775-14-6
Sodium hydroxide               1310-73-2
Sodium nitrite                 7632-00-0
Sodium Pyrophosphate           7722-88-5
Sodium sulfate                 7757-82-6
Sodium sulfite                 7757-83-7
Sodium thiocyanate             540-72-7
Calcium Carbonate              471-34-1
Calcium chloride               10043-52-4
Calcium gluconate              299-28-5
Calcium hydroxide              1305-62-0
Calcium phosphate, dibasic     7757-93-9
Calcium sulfate                7778-18-9
N-Methyl-D-glucamine           6284-40-8
Calcium oxide                  1305-78-8
Calcium Phosphate Monobasic    7758-23-8
Magnesium chloride hexahydrate 7791-18-6
Magnesium sulfate              7487-88-9
Magnesium Sulfate Heptahydrate 10034-99-8
Aluminum chloride hexahydrate  7784-13-6
aluminum nitrate nonahydrate   7784-27-2
Aluminum potassium sulfate,    7784-24-9
dodecahydrate
Aluminum sulfate,              7784-31-8
octadecahydrate
(S)-(−)-Cysteine               52-90-4
p-Toluenesulfonic Acid         104-15-4
Potassium bitartrate           868-14-4
DL-aspartic acid               617-45-8
p-Dimethylaminobenzaldehyde    100-10-7
Sodium salicylate              54-21-7
Benzoin                        119-53-9
Sodium dodecyl sulfate         151-21-3
L-Menthol                      2216-51-5
Tiron                          149-45-1
Riboflavin                     83-88-5
Sodium Acetate Trihydrate      6131-90-4
Disodium Succinate Hexahydrate 6106-21-4
Disodium                       6381-92-6
ethylenediaminetetraacetate
dihydrate
sodium citrate, dihydrate      1545801
Sodium potassium tartrate,     6381-59-5
tetrahydrate
L-(+)-Arginine                 1119-34-2
monohydrochloride
Ethylenediamine                333-18-6
dihydrochloride
Sodium formate                 141-53-7
Sodium acetate                 127-09-3
Potassium acetate              127-08-2
Ammonium citrate               3012-65-5
Ammonium bicarbonate           1066-33-7
Ammonium chloride              12125-02-9
Ammonium nitrate               6484-52-2
Ammonium persulfate            7727-54-0
Ammonium sulfate               7783-20-2
Zinc chloride                  7646-85-7
Sulfuric acid, zinc salt       7446-20-0
(1:1), heptahydrate
Sodium Tripolyphosphate        7758-29-4
ammonium benzoate              1863-63-4
ammonium bisulfite             10192-30-0
1,5-Naphthalenedisulfonic Acid 1655-29-4
Disodium Salt
4-Hydroxybenzoic Acid          99-96-7
Diphenylacetic Acid            117-34-0
Glutaric Acid                  110-94-1
L-(−)-Fucose                   2438-80-4
L-Cysteine Hydrochloride       52-89-1
L-Histidine Hydrochloride      1880304
Monohydrate
o-Toluic Acid                  118-90-1
Pivalic Acid                   75-98-9
Pyruvic Acid Sodium Salt       113-24-6
Potassium bromide              2139626
Sodium Dithionate Dihydrate    7631-94-9
Sodium Malonate                141-95-7
Trisodium Citrate              68-04-2
Potassium Sodium Tartrate      304-59-6
Potassium Citrate              866-84-2
D-Maltose Monohydrate          6363-53-7
Cyclohexaamylose               10016-20-3
Dodecyl sulfate, lithium salt  2044-56-6
Manganese chloride             2145076
methyl-urea                    598-50-5
beta-Cyclodextrin              7585-39-9
Triphosphoric acid,            13845-36-8
pentapotassium salt
Glycine ethyl ester            623-33-6
hydrochloride
L-Histidine methyl ester       7389-87-9
dihydrochloride
L-Leucine methyl ester         7517-19-3
hydrochloride
D-Lysine hydrochloride         7274-88-6
2-Naphthalenesulfonic acid     532-02-5
sodium salt
calcium nitrate tetrahydrate   13477-34-4
Vitamin B1                     59-43-8
Zinc Acetate Dihydrate         5970-45-6
Potassium fluoride             7789-23-3
Potassium iodate               2139718
Potassium iodide               7681-11-0
Potassium thiocyanate          333-20-0
Sodium bromide                 7647-15-6
Sodium fluoride                7681-49-4
Sodium iodide                  7681-82-5
Sodium nitrate                 7631-99-4
Calcium acetate                5743-26-0
Trichloroacetic acid           76-03-9
Ammonium acetate               631-61-8
Ammonium fluoride              12125-01-8
DL-malic acid                  617-48-1
t-Butyl Alcohol                75-65-0
beta-Alanine                   107-95-9
(S)-(−)-Tryptophan             73-22-3
Malonic acid                   141-82-2
Phenethylamine                 64-04-0
Salicylylaldehyde              90-02-8
Sodium benzoate                532-32-1
Mandelic acid                  90-64-2
Calcium pantothenate           137-08-6
Chloroacetic Acid              79-11-8
Ethanol Amine                  141-43-5
Salicylic acid                 69-72-7
Saccharin sodium               128-44-9
Thiamine hydrochloride         67-03-8
2,2′-Oxybisethanol             111-46-6
Resorcinol                     108-46-3
2-Amino-2-(hydroxymethyl)-1,3- 77-86-1
propanediol
2,5-Dimethylphenol             95-87-4
Ammonium Phosphate Monobasic   7722-76-1
1,3-Butanediol                 107-88-0
Glycolic Acid                  79-14-1
Sodium Gluconate               527-07-1
Terephthalic Acid              100-21-0
L-Ascorbic Acid Sodium Salt    134-03-2
3-Acetyl-6-methyl-2,4-         520-45-6
pyrandione
Calcium Acetate                62-54-4
Nicotinamide                   98-92-0
1-Hydroxy-2-naphthoic Acid     86-48-6
2-Isopropylphenol              88-69-7
4-Aminosalicylic Acid          65-49-6
Calcium Glycerophosphate       27214-00-2
Erythorbic Acid Sodium Salt    7378-23-6
Gluconic Acid Potassium Salt   299-27-4
Orotic Acid                    65-86-1
p-Anise Alcohol                105-13-5
Potassium Benzoate             582-25-2
Taurine                        107-35-7
Thiamine Nitrate               532-43-4
3,3,5-Trimethyl-1-cyclohexanol 116-02-9
tert-Butylhydroquinone         1948-33-0
Sulfosalicylic acid            97-05-2
Gallic acid                    149-91-7
L-borneol                      464-45-9
Isoborneol                     124-76-5
2,5-Dihydroxybenzoic acid,     490-79-9
Gentisic acid
5-hydroxy-6-methyl-3,4-        65-23-6
pyridinedimethanol
Naphthalene-2-sulfonic acid    120-18-3
Ethanesulfonic acid, 2-        1562-00-1
hydroxy-, monosodium salt
Pamoic acid                    130-85-8
2,4-Dimethylphenol             105-67-9
3,5-Dihydroxyacetophenone      51863-60-6
Eugenol                        97-53-0
n-Butyric Acid                 107-92-6
Hydroquinone                   123-31-9
Propionic Acid                 79-09-4
meta-Phenylenediamine          108-45-2
Oxalic Acid                    144-62-7
n-Hexanoic Acid                142-62-1
2-Furancarboxylic Acid         88-14-2
4′-Nitroacetanilide            104-04-1
D-(−)-Tartaric Acid            147-71-7
p-Acetamidobenzoic Acid        556-08-1
Galactaric acid                526-99-8
D-glucuronate                  1700908
Lactobionic acid               96-82-2
p-Formylacetanilide            122-85-0
2-Mercaptobenzoic acid         147-93-3
Propanoic acid, 2-hydroxy-,    28305-25-1
calcium salt (2:1), (S)-
D(+)-10-Camphorsulfonic acid   3144-16-9
3-Cyclopentylpropionic acid    140-77-2
1R-(−)-Camphorsulfonic acid    35963-20-3
DL-Lysine                      70-54-2
Cinnamic acid                  621-82-9
Triethanolamine                102-71-6
Acetic Acid                    64-19-7
Dichloroacetic Acid            79-43-6
Diethylamine                   109-89-7
Diethylaminoethanol            100-37-8
N-(2-Hydroxyethyl)Morpholine   622-40-2
Octanoic Acid                  124-07-2
isobutyric acid                79-31-2
Anisic Acid                    100-09-4
Betaine                        107-43-7
Enanthoic Acid                 111-14-8
Hippuric Acid                  495-69-2
Tiglic Acid                    80-59-1
Cyclohexanecarboxylic acid     98-89-5
m-Methoxybenzoic acid          586-38-9
D-(+)-Camphoric acid           124-83-4
N-(2-Hydroxyethyl)pyrrolidine  2955-88-6

TABLE 4
Crystal data and structure refinement for
Fluoxetine HCl:Benzoic acid (1:1).
Identification code	Fluoxetine HCl:Benzoic acid (1:1)
Empirical formula	C24 H25 C1 F3 N O3
Formula weight	467.90
Temperature	100(2) K
Wavelength	0.71073 Å
Crystal system	Monoclinic
Space group	P2(1)/n
Unit cell dimensions	a = 14.806(5) Å	α = 90°.
	b = 13.179(4) Å	β = 97.738(13)°.
	c = 24.417(7) Å	γ = 90°.
Volume	4721(2) Å3
Z	8
Density (calculated)	1.317 Mg/m3
Absorption coefficient	0.210 mm−1
F(000)	1952
Crystal size	0.47 × 0.15 × 0.10 mm3
Theta range for data collection	1.52 to 33.07°.
Index ranges	−22 <= h <= 22, −20 <= k <= 20,
	−37 <= 1 <= 37
Reflections collected	82494
Independent reflections	17030 [R(int) = 0.0751]
Completeness to theta = 33.07°	95.0%
Absorption correction	None
Refinement method	Full-matrix least-squares on F2
Data/restraints/parameters	17030/0/581
Goodness-of-fit on F2	1.053
Final R indices [I > 2sigma(I)]	R1 = 0.0853, wR2 = 0.1933
R indices (all data)	R1 = 0.1330, wR2 = 0.2168
Largest diff. peak and hole	2.571 and −0.689 e · Å−3

TABLE 5
Crystal data and structure refinement for Fluoxetine
HCl-succinic acid (2:1).
Identification code	Fluoxetine HCl-succinic acid (2:1)
Empirical formula	C38 H42 C12 F6 N2 O6
Formula weight	807.64
Temperature	100(2) K
Wavelength	0.71073 Å
Crystal system	Orthorhombic
Space group	Pbcn
Unit cell dimensions	a = 26.620(2) Å	α = 90°.
	b = 7.2147(7) Å	β = 90°.
	c = 20.8315(19) Å	γ = 90°.
Volume	4000.8(6) Å3
Z	4
Density (calculated)	1.341 Mg/m3
Absorption coefficient	0.236 mm−1
F(000)	1680
Crystal size	0.21 × 0.18 × 0.09 mm3
Theta range for data collection	1.53 to 27.50°.
Index ranges	−34 <= h <= 34, −9 <= k <= 9,
	−26 <= 1 <= 27
Reflections collected	37123
Independent reflections	4600 [R(int) = 0.0748]
Completeness to theta = 27.50°	100.0%
Absorption correction	Semi-empirical from equivalents
Max. and min. transmission	1.000 and 0.813837
Refinement method	Full-matrix least-squares on F2
Data/restraints/parameters	4600/0/249
Goodness-of-fit on F2	1.156
Final R indices [I > 2sigma(I)]	R1 = 0.0786, wR2 = 0.1782
R indices (all data)	R1 = 0.0911, wR2 = 0.1852
Largest diff. peak and hole	0.682 and −0.499 e · Å−3

TABLE 6
Crystal data and structure refinement for
Nabumetone:2,3-naphthalenediol (1:1).
Identification code	Nabumetone:2,3-naphthalenediol (1:1)
Empirical formula	C25 H24 O4
Formula weight	388.44
Temperature	100(2) K
Wavelength	1.54178 Å
Crystal system	Monoclinic
Space group	P2(1)/n
Unit cell dimensions	a = 17.1585(7) Å	α = 90°.
	b = 5.5168(3) Å	β = 91.319(3)°.
	c = 20.7083(9) Å	γ = 90°.
Volume	1959.73(16) Å3
Z	4
Density (calculated)	1.317 Mg/m3
Absorption coefficient	0.710 mm−1
F(000)	824
Crystal size	0.21 × 0.08 × 0.025 mm3
Theta range for data collection	3.31 to 66.15°.
Index ranges	−17 <= h <= 19, −6 <= k <= 5,
	−24 <= 1 <= 23
Reflections collected	8803
Independent reflections	3063 [R(int) = 0.0801]
Completeness to theta = 66.15°	89.1%
Absorption correction	None
Refinement method	Full-matrix least-squares on F2
Data/restraints/parameters	3063/2/266
Goodness-of-fit on F2	1.019
Final R indices [I > 2sigma(I)]	R1 = 0.0528, wR2 = 0.1332
R indices (all data)	R1 = 0.1116, wR2 = 0.1692
Largest diff. peak and hole	0.277 and −0.325 e · Å−3

TABLE 7
Crystal data and structure refinement for Fluoxetine
HCl-fumaric acid (2:1).
Identification code	a6g41m
Empirical formula	C38 H42 C12 F6 N2 O6
Formula weight	807.64
Temperature	173(2) K
Wavelength	1.54178 Å
Crystal system	Orthorhombic
Space group	Pbcn
Unit cell dimensions	a = 26.6914(8) Å	α = 90°.
	b = 7.1807(3) Å	β = 90°.
	c = 20.6546(7) Å	β = 90°.
Volume	3958.7 (2) Å3
Z	4
Density (calculated)	1.355 Mg/m3
Absorption coefficient	2.130 mm−1
F(000)	1680
Crystal size	0.20 × 0.14 × 0.08 mm3
Theta range for data collection	3.31 to 58.93°.
Index ranges	−24 <= h <= 29, −7 <= k <= 7,
	−21 <= 1 <= 22
Reflections collected	15698
Independent reflections	2823 [R(int) = 0.1693]
Completeness to theta = 58.93°	99.7%
Absorption correction	None
Refinement method	Full-matrix least-squares on F2
Data/restraints/parameters	2823/0/246
Goodness-of-fit on F2	1.018
Final R indices [I > 2sigma(I)]	R1 = 0.0469, wR2 = 0.0927
R indices (all data)	R1 = 0.0940, wR2 = 0.1197
Largest diff. peak and hole	0.583 and −0.750 e · Å−3

Claims

1. A method of screening for a cocrystal of a hydrochloric acid salt of an active agent, comprising the steps of: selecting a carboxylic acid having at least 4 carbons to coordinate via hydrogen bonding with the chloride anion of the hydrochloric acid salt of the active agent,preparing a solution, melt, or physical mixture of the hydrochloric acid salt of the active agent and the carboxylic acid,subjecting the solution or melt to a crystallization process, or the physical mixture to grinding, anddetermining whether a cocrystal of the hydrochloric acid salt of the active agent and the carboxylic acid has formed.

2. The method of claim 1 wherein the carboxylic acid having at least 4 carbons is selected from benzoic acid, succinic acid, and fumaric acid.

3. The method of claim 1 wherein the active agent is an active pharmaceutical ingredient.

4. The method of claim 1 wherein the active agent is a nitrogen containing base.

5. The method of claim 4 wherein the nitrogen containing base is a tertiary amine.

6. The method of claim 4 wherein the nitrogen containing base is a secondary amine.

7. The method of claim 4 wherein the nitrogen containing base is a primary amine.

8. The method of claim 1 wherein x-ray diffraction is used to determine whether a cocrystal of the hydrochloric acid salt of the active agent and the carboxylic acid has formed.

9. The method of claim 1 wherein the preparing step comprises preparing a solution of the hydrochloric acid salt of the active agent and the carboxylic acid.

10. The method of claim 1 wherein the preparing step comprises preparing a melt of the hydrochloric acid salt of the active agent and the carboxylic acid.

11. The method of claim 1 wherein the preparing step comprises preparing a physical mixture of the hydrochloric acid salt of the active agent and the carboxylic acid.