1. Field of the Invention
The present invention relates generally to selective and extended photothermolysis for cosmetic, health and dermatology conditions, and more particularly, to a portable device for photo-inducing damage to cellular structures for hair removal and method for operation of same.
2. Brief Description of the Background Art
Electromagnetic energy, particularly in the optical band of 400 nm to 1200 nm, has been used for treatment of many skin related diseases as well as for cosmetic procedures, e.g., hair removal, spider veins, tattoos, port wine stains, skin rejuvenation and photodynamic therapy. Laser and light-based removal of hair, both in men and women, is widely accepted as a successful approach. In today's market place, manufacturers have focused on four laser-based systems: alexandrite (755 nm); neodymium-doped yttrium aluminum garnet (1064 nm); laser diodes (810 nm); and a broad band intense pulsed light (IPL) source. Generally, these systems provide reduction in the growth cycle of hair. Multiple treatments have been found to improve upon longevity of the hair free period. An endpoint for an acceptable treatment requires destruction of pleuripotential follicular stem cells and not merely evaporation of the hair shaft.
Recent data suggests that stem cells are found in upper bulb and bulge regions of the hair follicle. Indeed there may be other areas not yet identified. Laser hair removal (LHR) procedures target these regions of the stem cells, as they are responsible for hair growth. Several techniques have been developed for destruction of stem cells.
Laser ablation, not typically used for photoepilation, uses high energy short pulses to raise the temperature of the stem cell above that required for evaporation, however, the target and the absorber must be collocated. Selective photothermolysis exploits dissimilar absorption coefficients of the photo absorbers and surrounding tissue. However, use of selective photothermolysis for destroying the stem cells responsible for hair growth is compounded because the photo-absorbing chromophore, melanin, is found both in the follicular stem cells and the epidermis. Melanin has a broad absorption spectrum and is responsible for pigmentation of the hair shaft and skin. Selective photothermolysis techniques are effective if a concentration of melanin is higher, by a factor of five, in the target area. These techniques work particularly well for dark hair on light skin. However, unavoidable absorption of photons in the epidermis leads to heat, which needs to be removed to avoid damage to the epidermis. Consequently, hand-pieces that chill the epidermis during treatment have been developed.
Destruction of cells through thermal denaturing requires that a target temperature exceed 70° C. within the thermal relaxation time (TRT) of the tissue. For the hair shaft, the TRT is in the range of 35 to 50 ms. Pulse widths exceeding the TRT permit diffusion of heat into surrounding tissue preventing the denaturing temperature from being reached due to heat leakage. Typically, LHR devices target about a 1 cm2 area of the skin, which is bombarded with photons. Some photons are absorbed in the epidermis, while the remaining migrate, via scattering, through the dermis and reach the melanin rich hair shaft and bulb region, where absorption leads to elevation of tissue temperature causing cell destruction. The photons scattered in the backward direction return back to the epidermis resulting in fluence levels exceeding the incident fluence.
Based on photon transport theory and clinical data, an optimum set of parameters can be established for a particular device. Unfortunately, these parameters are patient dependent and use of LHR devices remains an art.
A typical laser diode system will have a variable fluence between 20 to 60 J·cm−2, a pulse width in the range of 5 to 500 ms, and a treatment spot size of ˜1 cm2. The peak power of the source, which determines the size of the LHR system, is proportional to the product of fluence and spot area and inversely proportional to the pulse width. For example, a 100 μs pulse with a spot area of 1 cm2 requires a peak pulse power of 20 kW for a fluence of 20 J·cm2. Consequently, this leads to bulky and expensive machines, which need full medical facilities for operation. While the large diameter reduces treatment time and increases penetration depth into the dermis, it lacks the capability to selectively remove hair from a given area, i.e., to reduce hair density.
Another approach for permanent hair removal is based on extended selective photothermolysis (ESP). The target to be denatured can be separated from a photo-absorber, known as a heat source. A closer study of the underlying thermal diffusive processes has led to use of longer pulses to produce a hot spot in the melanin rich hair shaft. The longer laser pulse produces a hot spot, which begins to heat the surrounding tissue, including the hair bulb and bulge. Pulse width is determined by the TRT and the thermal damage time (TDT). Recent studies have indicated, particularly for techniques using the hair shaft for heat transmission, that a longer pulse width up to 1.5 seconds may be acceptable, which substantially decreases the peak power requirement. Several LHR systems with peak power up to 200 W using laser diode arrays are now on the market.
Other procedures for efficiently using the available photons in LHR devices include a pretreatment that applies highly reflective and thermally conductive applications to the skin prior to laser treatment. Ultrasonic massaging increases penetration of a dye into the epidermis. Pre-treatments can be used with any of the light-based techniques to enhance efficacy of hair removal, but adds extra time and cost to the treatment.
U.S. Pat. No. 7,118,563 to Weckwerth discloses a rechargeable device suitable for providing therapeutic energy. However, the minimum spot size of 0.25 cm2 is too large for targeting single hair follicles and causes a reduction in the peak power requirement. The system disclosed by Weckwerth also lacks any imaging device for identifying a treatment area.
U.S. Pat. No. 7,220,254 to Altshchuler teaches that existing technology can be packaged into a self-contained hand-held device for delivery of therapeutic energy to a skin treatment area and can be visualized by an image capturing system integrated into the hand-held device. The device combines discrete optical and electronic components to illuminate an area of the skin to facilitate imaging by a charge coupled device/complementary metal oxide semiconductor (CCD/CMOS) device. Imaging and treatment optical paths are separated by a beam splitter. A more compact and user-friendly hand-held device, with few components, would be more desirable, particularly for the home market.
U.S. Pub. No. 2007/0198004 to Altshchuler et al. addresses some of the above problems in disclosing a tethered hand-piece which may be more appropriate for the home market. However, conventional photo cosmetic devices do not include imaging capability and use lower power EMR sources having prolonged exposure times. For hair removal, such devices recommend power levels in the range of 20-500 W, which is not attainable by a single laser diode.
The present disclosure has been made to address at least the above problems and disadvantages, and to provide at least the advantages described below. Accordingly, an aspect of the present disclosure provides an apparatus for hair removal that includes a light source, a coherent imaging fiber, a plurality of multimode optical fibers configured to transmit energy from the light source, and an applicator configured to house each proximal end of each optical fiber of the plurality of multimode optical fibers, with the coherent imaging fiber transmitting an image of a hair follicle from among a plurality of hair follicles, for viewing on a display.
Another aspect of the present disclosure provides a hair removal method that includes positioning an applicator configured to house proximal ends of each optical fiber of a plurality of multimode optical fibers and a proximal end of a coherent imaging fiber above a plurality of hair follicles; viewing, via the coherent imaging fiber, an image of a hair follicle to be removed from among a plurality of hair follicles; and transmitting, from a light source via the plurality of multimode optical fibers, energy to the hair follicle to be removed from among the plurality of hair follicles.
The above and other objects, features and advantages of certain embodiments of the present invention will be more apparent from the following detailed description taken in conjunction with the accompanying drawings, in which:
The following detailed description of preferred embodiments of the invention will be made in reference to the accompanying drawings. In describing the invention, explanation about related functions or constructions known in the art are omitted for the sake of clearness in understanding the concept of the invention, to avoid obscuring the invention with unnecessary detail.
Embodiments of the present invention provide a portable and inexpensive apparatus for locating and capturing an image of a small treatment area, typically, about 250 microns in diameter. Further, the apparatus, typically less than 15 mm in diameter, delivers optical energy from a remote source to a target area, preferably smaller than a size of the image. The small size the apparatus is particularly useful for treating areas that require a reduction of hair density and not indiscriminate hair removal. In a preferred embodiment, the apparatus includes a hand piece mounted on a robotic arm for automated laser hair removal.
Additionally, the small treatment laser spot can be scanned across the target area to synthesize a larger treatment area. Referring to
Illumination of the treatment surface is achieved by coupling an output from white light emitting diodes 112, 113 to the proximal end of a plurality multimode optical fibers 115, 116, which transport the light to the HPA 100. Intensity of illumination is controlled through control module 122.
An optical system responsible for delivering a high energy therapeutic laser pulse (TLP) to the target uses the same CIF 109 to capture the image of the target. In the manual mode, transmission of the TLP is initiated by a user command, which is generated by an ON/OFF optical switch 120 mounted in the HPA 100. Upon receiving an ON signal from the LED driver assembly, the embedded processor system 107 sends out a programmed series of pulses to a laser diode (LD) driver 123, to power a high power laser diode 124, which is pigtailed to multimode optical fibers 125, the output from the distal end is imaged to the proximal end 110 of the CIF 109 via a source imaging aspheric lens and the dichroic mirror beam splitter 119. The electro-mechanical shutter prevents accidental leakage of the high laser energy, and its operation is synchronized with the ON/OFF pulse. A proximal image of the TLP is transported to the distal end 108 of the CIF 109 in the HPA 100. In this manner, the TLP is delivered precisely to the target 106 with negligible energy leakage beyond the treatment area 103. Pulse parameters are adjustable through the embedded processor system 107.
The optical switch 120, also discussed in
As illustrated in
During treatment, the CIF 109 delivers the optical energy to the target 106. As illustrated in
The optical signal is detected by the photodetector 130 (
Decreasing a requirement for peak power through a reduced spot size of the TLP pulse is not a viable solution as the photons migrate out of the target zone very rapidly. Moving to a smaller spot size demands new delivery methods for reaching the intended targets. Three optical delivery techniques are provided which target individual hair follicles, typically with a spot size smaller than 10−4 cm2. One of these is ESP, which uses heat diffusion to reach the intended targets by creating hot spots in easily accessible parts of the hair follicle, mainly the hair shaft 407. However, delivering the TLP directly to the hair shaft 407, which has a nominal diameter of 80 μm, requires precise spatial location. Imaging and sensor techniques have been proposed for achieving this goal, but all of the proposed solutions include scanning functionality in the hand piece, something that should be avoided if the device is to be utilized in non-medical facilities.
As illustrated in
A third illumination strategy can be a combination of both those described above. A short pulse width donut beam can be superimposed on a long pulse width Gaussian beam toward the end of the short pulse width donut beam's duration, as indicated by the timing diagram in
Referring to
The distal end 706 can be integrated with an source aspheric imaging lens assembly.
There may be instances when a larger spot is required. As discussed above, with reference to
In
The scanned image can be generated in a number of ways.
There are certain situations when indiscriminate hair removal using a large diameter spot is not desirable. As an example, for cosmetic purposes, patients may require an alteration of the hair density in certain parts of the human anatomy rather than total hair removal. For such applications a LHR system must be capable of targeting individual hair follicles. The HPA 100 described above can be used on a robotic platform to remove hair from any random location. One such embodiment includes a three-dimensional system that creates a digital map of a surface to be treated. Appropriate software algorithms that analyze hair distribution and hair angle determine optimum location information of hair follicles to receive laser treatment. The location information drives the robotic arm to automatically complete the treatment. Safety features, built around limit switches, ensure that the high energy spot remains within the treatment area.
Another preferred embodiment of the HPA 100 is illustrated by
An example of a fluence calculation in a preferred embodiment is as follows. An expected fluence Ft [J·cm−2] at the target 106 of area At [cm2] to the power Pf emanating from a pigtailed laser diode assembly is given by Equation (1):
where η represents all the transmission losses from the output of the fiber assembly to the laser spot illuminating the treatment area 106 and σT is the pulse width or duration of the optical energy pulse which can be easily controlled between 100 μs to 1 s. Using a conservative estimate of η=0.85, Pf=200 mW, At=10−4 cm2, which is a typical diameter of the hair shaft, and σT=50 ms, Ft=85 J·cm2 is obtained. Thus, the fluence can be controlled through a combination of parameters, Pf, σT, and AT.
A non-contact temperature sensor detects treatment surface temperature by capturing a portion of the radiated electromagnetic spectrum in the near to mid Infrared region. For example, a Melexis Infrared thermometer, e.g., MLX90615, pigtailed from an imaging fiber, converts emissions in the spectral band of 5.5 μm to 14 μm into a digital code corresponding to temperature in the range of −20° C. to 85° C. The non-contact temperature sensor operates via an optical fiber optimized for transmission in a mid infrared range of wavelengths to guide radiated emission from the treatment surface directly to the sensor. Output of the non-contact temperature sensor is utilized to generate an abort signal to shut-down the high power laser diode 124 when the measured surface temperature exceeds a prescribed temperature threshold. The abort signal disconnects the high power laser diode 124 from driver 123, resulting in the immediate cessation of the treatment. This sensory feedback arrangement, based on continuous temperature monitoring of the treatment surface, prevents burning in the treatment area, and ensures safe operation.
The non-contact temperature sensor can output directly into the applicator hand piece 100 and send the abort signal through the flexible umbilical cord 101 to the high power laser diode 124. However, direct output to the applicator hand piece 100 is not preferred since low current electrical signals are transmitted through the flexible umbilical cord 101, and such signals will be subject to added noise.
While the invention has been shown and described with reference to certain embodiments of the present invention thereof, it will be understood by those skilled in the art that various changes in from and details may be made therein without departing from the spirit and scope of the present invention as defined by the appended claims and equivalent thereof.
This application is a Continuation In Part application of U.S. application Ser. No. 12/246,097, filed Oct. 6, 2008, and issued as U.S. Pat. No. 9,474,576 on Oct. 25, 2016, and claims priority to U.S. Provisional Application No. 60/977,851, filed Oct. 5, 2007, the content of each of which is incorporated herein by reference.
Number | Date | Country | |
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60977851 | Oct 2007 | US |
Number | Date | Country | |
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Parent | 12246097 | Oct 2008 | US |
Child | 15333489 | US |