Claims
- 1. A method for promoting wound healing of a wound of a human subject, comprising the steps of:
- topically applying to the wound of the human subject a matrix having a density of about 0.01 to about 0.3 g/cm.sup.3, a thickness of about 1-20 mm, and pores at least 80% of which are at least 35 .mu.m in diameter, wherein said matrix comprises:
- fibrillar atelopeptide collagen, wherein said fibrils are about 50-200 nm in diameter, and are not chemically crosslinked;
- a pharmaceutically effective amount of a biological growth factor; and
- allowing the matrix to remain in contact with the wound for a period of time sufficient for the growth factor to promote wound healing.
- 2. The method of treatment as claimed in claim 1, wherein the biological growth factor is selected from the group consisting of TGF-.beta. including .beta.1 and .beta.2 forms, PDGF-AA, PDGF-AB, PDGF-BB, EGF, acidic FGF, basic FGF, TGF-.alpha., connective tissue activating peptides, .beta.-thromboglobulin, insulin-like growth factors, tumor necrosis factors, interleukins, nerve growth factors and interferons.
- 3. The method as claimed in claim 2, wherein the biological growth factor is a TGF-.beta..
- 4. The method as claimed in claim 3, wherein the TGF-.beta. is TGF-.beta.1.
Parent Case Info
This application is a divisional application of U.S. application Ser. No. 07/630,299 filed Dec. 19, 1990, now a U.S. Pat. No. 5,110,604, which is a divisional application of U.S. application Ser. No. 07/213,726 filed Jun. 30, 1988, now a U.S. Pat. No. 5,024,841 to which applications we claim priority under 35 USC Section 120 and which applications are incorporated herein by reference in their entirety.
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Aug 1990 |
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Divisions (2)
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Number |
Date |
Country |
Parent |
630299 |
Dec 1990 |
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Parent |
213726 |
Jun 1988 |
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