Patent Grant
12128128
This application is a national stage application of International Application No. PCT/GB2018/050869, filed Mar. 29, 2018, which claims the benefit of GB Patent Application No. 1705140.0 filed Mar. 30, 2017, the entire contents of which are hereby incorporated herein by reference in their entireties.
The present invention relates to compositions for topical application. In particular, the present invention relates to compositions for topical application comprising colloidal silver and a combination of plant extracts, for use as cosmetics and/or medicaments.
There are a number of dermatological conditions and cosmetic skin conditions which may cause distress to humans or animals. Said distress may be due to sensations such as pain, itching, or burning. Said distress may alternatively or additionally be due to an unsightly appearance associated with the condition, such as reddening of the skin, dry skin, or pigmentation of the skin.
Sufferers presenting with these conditions often wish to alleviate their distress by using some form of remedy for the condition. One option for addressing these conditions may be the use of prescription or over-the-counter pharmaceutical preparations. However, there is a consumer demand for natural remedies, or non-pharmaceutical remedies.
Given that these conditions may affect only a portion of the surface of the body of a sufferer, there is a consumer demand for a local approach of addressing the dermatological condition or cosmetic skin condition, rather than a systemic approach. One such suitable approach may be a topical application of a remedy which may reduce or diminish the dermatological condition or cosmetic skin condition.
Accordingly, there is a need for compositions suitable for topical application to dermatological conditions and/or cosmetic skin conditions which may at least partially alleviate pain, itching, burning, reddening of the skin, dry skin, or pigmentation of the skin, as appropriate.
According to a first aspect of the present invention, there is provided a composition for topical application comprising a base, and dispersed within the base:
According to further aspects, there is provided:
2) A composition according to 1), wherein the composition comprises:
Further features and advantages of the invention will become apparent from the following description of preferred embodiments of the invention, given by way of example only, which is made with reference to the accompanying drawings.
In the specification and claims, a volume to volume ratio or percentage may be indicated by “(v/v)”. A weight to volume ratio or percentage may be indicated by “(w/v)”. A weight to weight ratio or percentage may be indicated by “(w/w)”. Unless otherwise specified, ratios or percentages are given in relation to the weight or volume of the total composition, as appropriate.
The unit “ppm” refers to “parts per million”, and may be used herein to indicate a concentration of a material in a fluid phase. Unless otherwise specified, all values given as ppm are given as weight to volume (w/v) percentages. Accordingly, 1 ppm is equivalent to 1×104% (w/v).
The compositions of the present invention are suitable for topical application. That is, the compositions may be applied to body surfaces such as the skin or mucous membranes.
Base
The composition comprises a base, or carrier. The base is used as a vehicle for the other components of the composition. For the avoidance of doubt, the term ‘base’ as used herein does not mean a Brønsted-Lowry base or a Lewis base.
The base is preferably a pharmaceutically acceptable base. The nature of the base may influence the formulation of the composition. For example, a suitable base may comprise water (in particular water purified by distillation, ion exchange, reverse osmosis or any other suitable method), or a mixture of water and C1-C4 alkanol. A composition comprising such a base may suitably provide a topically applicable aqueous suspension formulation. Depending on the ratio of water to C1-C4 alkanol, a topically applicable aqueous suspension may be more suitable for spray application (that is, the suspension is applied to the skin as droplets in an aerosol), or may be more suitable for manual application (that is, the user applies the suspension to the skin or mucous membrane with a cloth, pad, or part of their body, for example their hand).
In another example, a suitable base may be an oil, or emulsion of oil and water. In some embodiments, the base may be an ointment base.
Any suitable ointment base may be used. A suitable ointment base may comprise an oleaginous base. Oleaginous bases typically comprise hard paraffin, soft paraffin (also known as petroleum jelly, petrolatum, white petrolatum or multi-hydrocarbon), microcrystalline wax or ceresine. Such bases are typically anhydrous, or have a low water content. These bases may further comprise a film forming agent to provide a protective film after application to the skin. Suitable film forming agents include polyvinylpyrrolidone, polyvinyl alcohol and cellulose derivatives.
Another suitable ointment base may comprise an absorption base (also known as an emulsion base). Absorption ointment bases typically comprise either an oleaginous base as described above and a water-in-oil surfactant, or a hydrophilic oleaginous base, to allow for the formation of a water-in-oil emulsion upon addition of water. Such bases may comprise any of the oleaginous bases described above and/or components selected from: lanolin, beeswax, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, and sodium lauryl ether sulfate. Examples of appropriate absorption bases include hydrophilic petrolatum, anhydrous lanolin, Aquabase®, Aquaphor® and Polysorb®.
Another suitable ointment base may comprise a water-in-oil emulsion base. Water-in-oil emulsion bases typically comprise water and any of the ointment base components described above. In particular, water-in-oil emulsion bases typically comprise a water-in-oil surfactant. Examples of appropriate water-in-oil emulsion bases include cold creams, hydrous lanolin, rose water ointment, aqueous cream, Hydrocream®, Eucerin® and Nivea®.
Another suitable ointment base may comprise an oil-in-water emulsion base. Oil-in-water emulsion bases typically comprise water in an amount greater than that in a water-in-oil emulsion base, and any of the ointment base components described above. In particular, oil-in-water emulsion bases typically comprise an oil-in-water surfactant. Examples of appropriate oil-in-water emulsion bases include hydrophilic ointment, Dermabase®, Velvachol® and Unibase®.
Another suitable ointment base may comprise a water-miscible ointment base. Water-miscible ointment bases typically comprise a combination of low and high molecular weight polyethylene glycols. Examples of appropriate water-miscible ointment bases include PEG ointment and Polybase®.
A composition comprising such ointment bases as described above may suitably provide a topically applicable ointment formulation, or topically applicable cream formulation.
In another example, a suitable base may be a gel. ‘Gel’ as used herein refers to any dispersion of inorganic or organic molecules in a liquid system wherein there is at least some cross-linking or association between the inorganic or organic molecules. Gels may be prepared by combining a liquid such as water or aqueous C1-C4 alkanol with suitable gelling agent(s), such as carbomers, carboxymethyl cellulose, ethylcellulose, gelatin, hydroxyethyl cellulose, hydroxypropyl cellulose, magnesium aluminium silicate, methylcellulose, poloxamers, polyvinyl alcohol, sodium alginate, tragacanth, and xanthan gum. A composition comprising such a base may suitably provide a topically applicable gel formulation.
In another example, a suitable base may comprise water and/or C1-C4 alkanol and a propellant. Suitable propellants may include hydrocarbons, hydrofluorocarbons, and compressed gases. A composition comprising such a base may suitable provide a topically applicable aerosol formulation.
The base may be present in the composition in any suitable amount. Preferably, the base is the majority component of the composition. For example, the base may be present in the composition in an amount of from 80 to 99.9% (v/v), or 85 to 99.5% (v/v), or from 90 to 99% (v/v). The base may be present in the composition in an amount less than or equal to 99.9% (v/v), or 99.5% (v/v), or 99% (v/v), or 98% (v/v), or 97% (v/v), or 96% (v/v), or 95% (v/v), or 90% (v/v). The base may be present in the composition in an amount greater than or equal to 80% (v/v), 85% (v/v), 90%, 95% (v/v), 96% (v/v), 97% (v/v), 98% (v/v), 99% (v/v), 99.5% (v/v), or 99.9% (v/v).
In a preferred embodiment, the base comprises water. In a particular embodiment, the base essentially consists of water.
Silver
The composition also comprises elemental silver as colloidal silver, namely particulate elemental silver dispersed within the base as a colloidal suspension. The silver may be present in the composition in any suitable amount, for example in an amount of from 0.1 ppm to 100 ppm, or from 0.5 ppm to 50 ppm, or from 1 ppm to 10 ppm, or from 5 ppm to 10 ppm; that is, from 1×10−5 to 1×10−2% (w/v), or from 5×10−5 to 5×10−3% (w/v), or from 1×104 to 1×10−3% (w/v), or from 5×10−4 to 1×10−3% (w/v). The silver may be present in the composition in an amount less than or equal to 100 ppm, or 50 ppm, or 10 ppm; that is, less than or equal to 1×10−2% (w/v), or 5×10−3% (w/v), or 1×10−3% (w/v). The silver may be present in the composition in an amount greater than or equal to 0.1 ppm, or 0.5 ppm, or 1 ppm; that is, greater than or equal to 1×10−5% (w/v), or 5×10−5% (w/v), or 1×10−4% (w/v). Suitably, the silver may be present in the composition in an amount of approximately 5 ppm; that is, 5×104% (w/v).
Plant Extract
Compositions according to the present invention comprise plant extract. A plant extract refers to a substance that has been removed from plant material. Plant extracts may be prepared by treating any plant material with an extractant to extract at least some components of the plant material from the plant material into the extractant. Extractant may be referred to as solvent. The resulting extractant containing at least some components extracted from the plant material is referred to herein as “plant extract”. Put another way, “plant extract” may refer to components removed from plant material by treating the plant material with an extractant.
The plant material which is treated with extractant to provide a plant extract may be or derive from any part of a plant, for example, the leaves, bark, roots, seeds or fruits of the plant. In the preparation of plant extract, the plant components extracted from the plant material will be at least partially soluble or suspendable in the extractant. After the plant material has been treated with the extractant, the insoluble plant material may be left in the extractant, or the insoluble plant material may be separated from the extractant. The insoluble plant material may be separated from the extractant according to any appropriate method, for example, decantation, filtration or centrifugation. In preferred embodiments of the present invention, the insoluble plant material has been separated from the extractant; the plant extract does not comprise insoluble components. In a particularly preferred embodiment, the plant extract is prepared by cold percolation extraction. Cold percolation extraction includes placing plant material in a perforated flask or vessel, and treating the plant material with cold extractant. The resulting plant extract will pass through the perforation, leaving the insoluble and/or insuspendable plant material in the flask or vessel.
Suitable plant extract extractants include any which may be used to extract components from the plant material; that is, any extractant in which at least some of the components of the plant material are soluble or suspendable. In one embodiment, the extractant may comprise a C1-C4 alkanol. Suitable C1-C4 alkanols include methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol, and tert-butanol. In one embodiment, the extractant may comprise methanol and/or ethanol. In a particular embodiment, the extractant may comprise ethanol.
In another embodiment, the extractant may comprise acetic acid, glycerine (in particular vegetable glycerine), propylene glycol, honey, or water. Plant extracts may be prepared with hot water or cold water.
The extractant may comprise a combination of extractants. For example, the extractant may comprise a combination of any of the extractants given above. In a particular embodiment, the extractant may comprise water and a C1-C4 alkanol. Such a combination may be referred to as an aqueous C1-C4 alkanol. In a preferred embodiment, the extractant comprises water and ethanol. Such a combination may be referred to as aqueous ethanol.
In a further embodiment, the extractant may essentially consist of any one of the extractants given above, or a combination thereof. In a particular embodiment, the extractant may consist of water and a C1-C4 alkanol. In a preferred embodiment, the extractant consists of water and ethanol.
Aqueous ethanol may have any appropriate ethanol content. For example, the aqueous ethanol may have an ethanol content of from 5 to 95% (v/v), 10 to 90% (v/v), 20 to 80% (v/v), 30 to 70% (v/v), or 40 to 60% (v/v). The aqueous ethanol may have an ethanol content of greater than or equal to 5% (v/v), 10% (v/v), 20% (v/v), 30% (v/v), 40% (v/v), 50% (v/v), 60% (v/v), 70% (v/v), 80% (v/v), 90% (v/v), or 95% (v/v). The aqueous ethanol may have an ethanol content of less than or equal to 95% (v/v), 90% (v/v), 80% (v/v), 70% (v/v), 60% (v/v), 50% (v/v), 40% (v/v), 30% (v/v), 20% (v/v), 10% (v/v), or 5% (v/v).
The plant extracts suitable for use in the present invention may be prepared by treating plant material with extractant in any appropriate ratio. For example, plant extracts for use in the present invention may be prepared by treating plant material with extractant in a ratio of from 2:1 to 1:20 (w/v) plant material to extractant, or from 1:1 to 1:10 (w/v) plant material to extractant, or from 1:2 to 1:9 (w/v) plant material to extractant.
Plant extracts suitable for use in the present invention may be referred to by a variety of names. Plant extracts suitable for use in the present invention particularly include products which may commercially be referred to as extracts (typically an aqueous ethanol extraction of plant material carried out in a ratio of approximately 1:1 (w/v) plant material to extractant), tinctures (typically an aqueous ethanol extraction of plant material carried out in a ratio of approximately 1:3 to 1:5 (w/v) plant material to extractant), mother tinctures (typically an aqueous ethanol extraction of plant material carried out in a ratio of approximately 1:9 (w/v) plant material to extractant), and tisanes such as infusions (typically a hot water extraction of plant material), decoctions (typically an aqueous extraction of plant material carried out in boiling water over an extended period of time) and macerations (typically an extraction of chopped plant material in cold water).
Plant extracts suitable for use with the present invention may be purchased from the vendor G Baldwin & Co.
In some embodiments, the plant extract is an extractant-free extract. That is, a plant extract has been prepared according to the above methods, and then the extractant has been removed to leave a dry substance. The dry substance may correspond to the plant components extracted from the plant material or derivatives thereof only.
The compositions of the present invention comprise plant extract from plants selected from Equisetum arvense (also known as common horsetail, or field horsetail), Rumex crispus (also known as curly dock, or yellow dock), Arctium lappa (also known as burdock, or greater burdock), Trifolium pratense (also known as red clover), Chelidonium majus (also known as greater celandine, tetterwort, nipplewort, or swallowwort), Thuja occidentalis (also known as northern white-cedar or eastern arborvitae), Urtica dioica (also known as nettle), Symphytum officinale (also known as comfrey, in particular, common comfrey), Mahonia aquifolium (also known as Oregon grape), Echinacea purpurea, Stellaria media (also known as chickweed), Galium aparine (also known as cleavers), Aloe vera (also known as Aloe barbadensis), Matricaria recutita (also known as chamomile), Hypericum perforatum (also known as St John's wort), Calendula officinalis (also known as common marigold), and Panax ginseng.
In some embodiments, the composition may contain other plant extracts in addition to those recited hereinabove. In other embodiments, the composition may contain only the plant extracts recited hereinabove and no other plant extracts.
The composition comprises a combination of extracts from at least 6 plants selected from the group given above. In some embodiments, the composition comprises a combination of extracts from at least 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17 plants selected from the group given above.
Without being bound by theory, it is believed that the combinations of plant extracts with colloidal silver as described herein may provide an alternative or better effect than the corresponding cumulative effect of the plant extracts or colloidal silver used individually.
Given that the plant extract in the composition described herein is invariably an extract from a combination of plants, it may be referred to as ‘the plant extract combination’.
Plant extract from a combination of plants can be provided as a single extraction from a combination of plants, or a combination of extracts from individual plants. Preferably, plant extract from a combination of plants is provided as a combination of extracts from individual plants. In embodiments comprising a combination of extracts from individual plants, the extracts from individual plants may be referred to as components of the plant extract combination.
The composition may comprise plant extract in any suitable amount. For example, the composition may comprise plant extract in an amount of from 0.1% to 10% (w/v), or 0.25% to 5% (w/v), or 0.5% to 2.5% (w/v), or 0.75% to 2% (w/v). The plant extract may be present in the composition in an amount less than or equal to 10% (w/v), 5% (w/v), 2.5% (w/v), 2% (w/v), or 1.5% (w/v). The plant extract may be present in the composition in an amount greater than or equal to 0.1% (w/v), or 0.25% (w/v), or 0.5% (w/v), or 0.75% (w/v), or 1% (w/v).
In embodiments wherein the plant extract is provided as a combination of extracts from individual plants, each component of the plant extract may be present in the composition any suitable amount. For example, each component of the plant extract may be present in the composition in an amount of from 0.05% to 10% (w/v), or 0.1% to 5% (w/v), or 0.25% to 2.5% (w/v), or 0.5% to 2% (w/v), or 0.6% (w/v) to 1% (w/v). Each component of the plant extract may be present in the composition in an amount less than or equal to 10% (w/v), 5% (w/v), 2.5% (w/v), 2% (w/v), or 1.5% (w/v), or 1% (w/v). Each component of the plant extract may be present in the composition in an amount greater than or equal to 0.05% (w/v), or 0.1% (w/v), or 0.25% (w/v), or 0.5% (w/v), or 0.6% (w/v), or 0.75% (w/v).
In embodiments wherein the plant extract is provided as an extractant-free plant extract, each component of the extractant-free plant extract may be present in the composition in an amount of from 0.01% to 1% (w/v), or 0.025% to 0.5% (w/v), or 0.05% to 0.25% (w/v), or 0.075% to 0.2% (w/v). The plant extract may be present in the composition in an amount less than or equal to 1% (w/v), 0.5% (w/v), 0.25% (w/v), 0.2% (w/v), or 0.15% (w/v). The plant extract may be present in the composition in an amount greater than or equal to 0.01% (w/v), or 0.025% (w/v), or 0.05% (w/v), or 0.075% (w/v), or 0.1% (w/v).
Plant extracts from individual plants may be combined in any ratio relative to each other to provide the plant extract combination. In some embodiments, the ratio between the component of the plant extract combination present in the largest amount and the component of the plant extract combination present in the smallest amount may be less than 10:1 (w/w), less than 8:1 (w/w), less than 6:1 (w/w), or less than 4:1 (w/w).
Use of Composition
The compositions of the present invention may be suitable for use with humans. For example, the compositions may be suitable for application to the skin and/or mucous membrane of a human body. In other embodiments, the compositions may be suitable for use with non-human animals. For example, the composition may be suitable for application to the skin, mucous membrane, hair and/or coat of animals. The composition may be suitable for application to the skin, mucous membrane, hair and/or coat of non-human animals such as fish, amphibians, reptiles, birds, and non-human mammals. In particular, the composition may be suitable for application to the skin, mucous membrane, hair and/or coat of household pets such as cats, dogs, rabbits, lizards, snakes, parrots, budgerigars and the like. Alternatively or additionally, the composition may be particularly suitable for application to the skin, mucous membrane, hair and/or coat of farmyard animals such as cows, pigs, sheep, horses, goats, donkeys and the like.
The compositions of the present invention may be used as medicaments. The compositions may be used as medicaments for a range of indications, for example dermatitis, psoriasis, wounds, tinea pedis (also known as Athlete's foot), blisters, insect bites, and inflammation. It may be that one combination of plant extracts is not optimal for treating all of the given indications. Rather, it may be that particular plant extract combinations are particularly suitable for use as medicaments for particular indications. Particular combinations and the indications they may be particularly suitable for are described herein.
Dermatitis may also be referred to as eczema. Dermatitis includes atopic dermatitis, contact dermatitis, xerotic dermatitis, and seborrhoeic dermatitis. Compositions of the present invention may particularly be used as a medicament for contact dermatitis including irritant diaper dermatitis (also known as nappy rash), and contact dermatitis deriving related to incontinence.
Wounds include open wounds such as incisions, lacerations, abrasions, avulsions, and puncture wounds. Open wounds may also be referred to as severed skin, or cuts. Wounds also include closed wounds such as hematomas. Hematomas include contusions (also referred to as bruises), petechiae, purpura and ecchymoses. Compositions of the present invention may particularly be used as a medicament for open wounds, and/or contusions. Some embodiments may increase the rate of healing of such wounds.
Burns include thermal burns, chemical burns and radiation burns. Compositions of the present invention may particularly be used as a medicament for radiation burns such as sunburn. Alternatively or additionally, compositions of the present invention may particularly be used as a medicament for thermal burns such as oil burns, iron burns, oven burns, and steam burns. Some embodiments may increase the rate of healing of such wounds.
The present invention also relates to a method of treating a dermatological condition. Said method comprises providing a composition as described herein, and applying the composition to the affected area. For example, the method may comprise providing a composition for use as a medicament for dermatitis, and applying said composition to a portion of skin presenting with dermatitis. Alternatively, the method may comprise providing a composition for use as a medicament for psoriasis, and applying said composition to a portion of skin presenting with psoriasis. Alternatively, the method may comprise providing a composition for use as a medicament for wounds, and applying said composition to a wound. Alternatively, the method may comprise providing a composition for use as a medicament for tinea pedis, and applying said composition to a portion of skin presenting with tinea pedis. Alternatively, the method may comprise providing a composition for use as a medicament for blisters, and applying said composition to at least part of the surface of the blister. Alternatively, the method may comprise providing a composition for use as a medicament for insect bites, and applying said composition to the insect bite. Alternatively, the method may comprise providing a composition for use as a medicament for inflammation, and applying said composition to a portion of inflamed skin.
The composition of the present invention may alternatively or additionally be a cosmetic composition. For instance, compositions may be applied to the skin to reduce the size and/or pigmentation of nevi (also known as moles), liver spots, areas of hyperpigmentation, reddened skin, and rashes.
The present invention also relates to non-therapeutic cosmetic methods. Said method comprises providing a composition as described herein, selecting an area of the body to which the composition should be applied, and topically applying the composition to the selected area. For example, the method may comprise providing a composition, selecting a nevi, and applying said composition to at least part of the surface of the nevi. Alternatively, the method may comprise providing a composition, selecting a liver spot, and applying said composition to at least part of the surface of the liver spot. Alternatively, the method may comprise providing a composition, selecting an area of hyperpigmentation, and applying said composition to at least part of the surface of the area of hyperpigmentation. Alternatively, the method may comprise providing a composition, selecting an area of reddened skin, and applying said composition to at least part of the surface of the reddened skin. Alternatively, the method may comprise providing a composition, selecting a rash, and applying said composition to at least part of the surface of the rash.
Compositions may also be used for providing the user with a sensation at the skin and/or mucous membrane. For example, application of the composition to the skin and/or mucous membrane may result in the user perceiving a cooling and/or soothing sensation.
The composition of the present invention may alternatively or additionally be used on the skin and/or hair of household pets such as cats, dogs etc.
The compositions of the present invention may be provided to the user in any form. For example, the composition may be provided alone, or in combination with a form of application. For example, in one embodiment, there is provided a dressing comprising a composition as described herein. In another embodiment, there is provided a porous sheet impregnated with a composition as described herein. Such an impregnated porous sheet may be referred to as a “wet wipe”.
Specific Combinations of Components
In a particular embodiment, the composition comprises water in an amount of from 80 to 99.9% (v/v). The composition also comprises elemental silver as a colloidal suspension in an amount of from 0.1 ppm to 100 ppm (that is, 1×10−5 to 1×10−2% (w/v)). The composition also comprises plant extract from at least 6 plants selected from the group consisting of Equisetum arvense, Rumex crispus, Arctium lappa, Trifolium pratense, Chelidonium majus, Thuja occidentalis, Urtica dioica, Symphytum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Galium aparine, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. The plant extract is present in the composition in an amount of from 0.1% to 10% (w/v).
In a further embodiment, the composition consists of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Equisetum arvense, Symphytum officinale, Mahonia aquifolium, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. This embodiment may be particularly suitable for use as a medicament for blisters.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Equisetum arvense, Symphytum officinale, Mahonia aquifolium, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Arctium lappa, Echinacea purpurea, Stellaria media, Matricaria recutita, Hypericum perforatum, and Calendula officinalis. This embodiment may be particularly suitable for use as a cosmetic composition to be applied to skin blemishes.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Arctium lappa, Echinacea purpurea, Stellaria media, Matricaria recutita, Hypericum perforatum, and Calendula officinalis in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Symphytum officinale, Echinacea purpurea, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. This embodiment may be particularly suitable for use as a medicament for burns.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Symphytum officinale, Echinacea purpurea, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Galium aparine, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. This embodiment may be particularly suitable for use as a medicament for sunburn.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Galium aparine, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise extracts from Equisetum arvense, Rumex crispus, Arctium lappa, Trifolium pratense, Chelidonium majus, Thuja occidentalis, Urtica dioica, Symphytum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Galium aparine, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. This embodiment may be particularly suitable for use as a medicament for eczema.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Equisetum arvense, Rumex crispus, Arctium lappa, Trifolium pratense, Chelidonium majus, Thuja occidentalis, Urtica dioica, Symphytum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Galium aparine, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Equisetum arvense, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. This embodiment may be particularly suitable for use as a medicament for open wounds.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Equisetum arvense, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Chelidonium majus, Thuja occidentalis, Echinacea purpurea, Galium aparine, Matricaria recutita, Hypericum perforatum, and Calendula officinalis. This embodiment may be particularly suitable for use as a medicament for tinea pedis.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Chelidonium majus, Thuja occidentalis, Echinacea purpurea, Galium aparine, Matricaria recutita, Hypericum perforatum, and Calendula officinalis in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Chelidonium majus, Thuja occidentalis, Mahonia aquifolium, Aloe vera, Matricaria recutita, and Calendula officinalis. This embodiment may be particularly suitable for use as a cosmetic composition to be applied to nevi.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Chelidonium majus, Thuja occidentalis, Mahonia aquifolium, Aloe vera, Matricaria recutita, and Calendula officinalis in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Arctium lappa, Urtica dioica, Echinacea purpurea, Stellaria media, Matricaria recutita, Hypericum perforatum, and Calendula officinalis. This embodiment may be particularly suitable for use as a medicament for insect bites.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Arctium lappa, Urtica dioica, Echinacea purpurea, Stellaria media, Matricaria recutita, Hypericum perforatum, and Calendula officinalis in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Urtica dioica, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, and Calendula officinalis. This embodiment may be particularly suitable for use as a medicament for irritant diaper dermatitis.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Urtica dioica, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, and Calendula officinalis in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Urtica dioica, Symphytum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. This embodiment may be particularly suitable for use as a medicament for contact dermatitis deriving from incontinence.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Urtica dioica, Symphytum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Rumex crispus, Arctium lappa, Trifolium pratense, Symphytum officinale, Echinacea purpurea, Stellaria media, Hypericum perforatum, Calendula officinalis, and Panax ginseng. This embodiment may be particularly suitable for application to the skin and hair of household pets.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Rumex crispus, Arctium lappa, Trifolium pratense, Symphytum officinale, Echinacea purpurea, Stellaria media, Hypericum perforatum, Calendula officinalis, and Panax ginseng in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Urtica dioica, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, and Calendula officinalis. This embodiment may be particularly suitable for including in a porous sheet (also known as a wet wipe).
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Urtica dioica, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, and Calendula officinalis in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
In one embodiment, the plant extract may comprise or consist of extracts from Rumex crispus, Arctium lappa, Trifolium pratense, Symphytum officinale, Echinacea purpurea, Stellaria media, Matricaria recutita, and Calendula officinalis. This embodiment may be particularly suitable for including in a porous sheet (also known as a wet wipe), for application to the skin and hair of household pets.
In a further embodiment, the composition may consist of elemental silver in an amount of from 1×10−5% to 1×10−2% (w/v), plant extract comprising or consisting of extracts from Rumex crispus, Arctium lappa, Trifolium pratense, Symphytum officinale, Echinacea purpurea, Stellaria media, Matricaria recutita, and Calendula officinalis in an amount of from 0.1% to 10% (w/v), and water as the remainder of the composition up to 100%.
Methods of Preparing Compositions
Compositions according to the present invention may be manufactured according to any suitable method. One appropriate method is to provide plant extract from at least 6 plants selected from the group consisting of Equisetum arvense, Rumex crispus, Arctium lappa, Trifolium pratense, Chelidonium majus, Thuja occidentalis, Urtica dioica, Symphytum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Galium aparine, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. The method further comprises providing a colloidal suspension of silver in a base, the silver content of the colloidal suspension being of from 0.1 ppm to 100 ppm (that is, 1×10−5% to 1×10−2% (w/v) of the base). The plant extract and colloidal suspension are then combined to provide a composition for topical application.
The base may be any of those described herein. In one embodiment, the base is water.
The plant extract and colloidal suspension of silver may be combined in any appropriate ratio. In one embodiment, they are combined in a ratio of from 1:20 to 1:4 (w/v) plant extract to colloidal suspension of silver, or from 1:15 to 1:6, or from 1:12 to 1:8. In one embodiment, they are combined in a ratio of around 1:9 (w/v) plant extract to colloidal suspension of silver.
Examples 1 to 14 provide topically applicable compositions comprising plant extracts prepared by extracting plant material with aqueous ethanol in a ratio of 1:1 weight/volume plant material to aqueous ethanol. The proportion of ethanol to water in the aqueous ethanol (i.e. the ethanol content) for each extract is as follows:
Equisetum arvense
Rumex crispus
Arctium lappa
Trifolium pratense
Chelidonium majus
Thuja occidentalis
Urtica dioica
Symphytum officinale
Mahonia aquifolium
Echinacea purpurea
Stellaria media
Galium aparine
Aloe vera
Matricaria recutita
Hypericum perforatum
Calendula officinalis
Panax ginseng
This is an example of a composition for applying to blisters.
Aqueous extracts of Equisetum arvense (0.20 mL), Symphytum officinale (0.40 mL), Mahonia aquifolium (0.20 mL), Matricaria recutita (0.20 mL), Hypericum perforatum (0.12 mL), Calendula officinalis (0.20 mL), and Panax ginseng (0.20 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to skin blemishes.
Aqueous extracts of Arctium lappa (0.20 mL), Echinacea purpurea (0.40 mL), Stellaria media (0.20 mL), Matricaria recutita (0.20 mL), Hypericum perforatum (0.12 mL), and Calendula officinalis (0.12 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to skin burns.
Aqueous extracts of Symphytum officinale (0.28 mL), Echinacea purpurea (0.12 mL), Aloe vera (0.20 mL), Matricaria recutita (0.20 mL), Hypericum perforatum (0.20 mL), Calendula officinalis (0.20 mL), and Panax ginseng (0.28 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to eczema.
Aqueous extracts of Equisetum arvense (0.20 mL), Rumex crispus (0.20 mL), Arctium lappa (0.08 mL), Trifolium pratense (0.28 mL), Chelidonium majus (0.08 mL), Thuja occidentalis (0.08 mL), Urtica dioica (0.12 mL), Symphytum officinale (0.20 mL), Mahonia aquifolium (0.20 mL), Echinacea purpurea (0.20 mL), Stellaria media (0.28 mL), Galium aparine (0.28 mL), Aloe vera (0.20 mL), Matricaria recutita (0.20 mL), Hypericum perforatum (0.12 mL), Calendula officinalis (0.12 mL), and Panax ginseng (0.20 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to cuts.
Aqueous extracts of Equisetum arvense (0.20 mL), Symphytum officinale (0.28 mL), Echinacea purpurea (0.20 mL), Stellaria media (0.12 mL), Aloe vera (0.20 mL), Matricaria recutita (0.12 mL), Hypericum perforatum (0.12 mL), Calendula officinalis (0.28 mL), and Panax ginseng (0.28 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to Tinea pedis (Athlete's Foot).
Aqueous extracts of Chelidonium majus (0.04 mL), Thuja occidentalis (0.20 mL), Echinacea purpurea (0.12 mL), Galium aparine (0.40 mL), Matricaria recutita (0.40 mL), Hypericum perforatum (0.12 mL), and Calendula officinalis (0.28 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to sunburn.
Aqueous extracts of Galium aparine (0.20 mL) Aloe vera (0.28 mL), Matricaria recutita (0.20 mL), Hypericum perforatum (0.28 mL), Calendula officinalis (0.28 mL), and Panax ginseng (0.20 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to moles.
Aqueous extracts of Chelidonium majus (0.12 mL), Thuja occidentalis (0.28 mL), Mahonia aquifolium (0.20 mL), Aloe vera (0.30 mL), Matricaria recutita (0.20 mL), and Calendula officinalis (0.28 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to insect bites.
Aqueous extracts of Arctium lappa (0.20 mL), Urtica dioica (0.28 mL), Echinacea purpurea (0.28 mL), Stellaria media (0.20 mL), Matricaria recutita (0.12 mL), Hypericum perforatum (0.20 mL), and Calendula officinalis (0.28 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to irritant diaper dermatitis.
Aqueous extracts of Urtica dioica (0.20 mL), Symphytum officinale (0.28 mL), Echinacea purpurea (0.28 mL), Stellaria media (0.20 mL), Aloe vera (0.28 mL), Matricaria recutita (0.28 mL), and Calendula officinalis (0.28 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for use in the treatment of contact dermatitis related to incontinence.
Aqueous extracts of Urtica dioica (0.20 mL), Symphytum officinale (0.28 mL), Echinacea purpurea (0.20 mL), Mahonia aquifolium (0.12 mL), Stellaria media (0.20 mL), Aloe vera (0.28 mL), Matricaria recutita (0.28 mL), Hypericum perforatum (0.20 mL), Calendula officinalis (0.28 mL), and Panax ginseng (0.28 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to the skin of household pets.
Aqueous extracts of Rumex crispus (0.20 mL), Arctium lappa (0.20 mL), Trifolium pratense (0.20 mL), Symphytum officinale (0.12 mL), Echinacea purpurea (0.20 mL), Stellaria media (0.12 mL), Hypericum perforatum (0.12 mL), Calendula officinalis (0.12 mL), and Panax ginseng (0.12 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition suitable to be provided in combination with a form of application, such as a porous sheet impregnated with the composition.
Aqueous extracts of Urtica dioica (0.20 mL), Symphytum officinale (0.28 mL), Echinacea purpurea (0.20 mL), Stellaria media (0.20 mL), Aloe vera (0.28 mL), Matricaria recutita (0.28 mL), and Calendula officinalis (0.28 mL), were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a composition. A porous sheet was treated with the resulting composition to provide a porous sheet impregnated with the composition (a “wet wipe”).
This is an example of a composition suitable to be provided in combination with a form of application, such as a porous sheet impregnated with the composition, wherein the composition is suitable for use with household pets.
Aqueous extracts of Rumex crispus (0.20 mL), Arctium lappa (0.20 mL), Trifolium pratense (0.20 mL), Symphytum officinale (0.12 mL), Echinacea purpurea (0.20 mL), Stellaria media (0.12 mL), Matricaria recutita (0.12 mL), and Calendula officinalis (0.12 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a composition. A porous sheet was treated with the resulting composition to provide a porous sheet impregnated with the composition (a “wet wipe”).
Examples 15 to 28 provide topically applicable compositions comprising mother tinctures prepared by extracting plant material with aqueous ethanol in a ratio of 1:9 weight/volume plant material to aqueous ethanol. The proportion of ethanol to water in the aqueous ethanol (i.e. the ethanol content) for each extract is as follows:
Equisetum arvense
Rumex crispus
Arctium lappa
Trifolium pratense
Chelidonium majus
Thuja occidentalis
Urtica dioica
Symphytum officinale
Mahonia aquifolium
Echinacea purpurea
Stellaria media
Galium aparine
Aloe vera
Matricaria recutita
Hypericum perforatum
Calendula officinalis
Panax ginseng
This is an example of a composition for applying to blisters.
Aqueous ethanol extracts of Equisetum arvense (0.32 mL), Symphytum officinale (0.40 mL), Mahonia aquifolium (0.32 mL), Matricaria recutita (0.32 mL), Hypericum perforatum (0.20 mL), Calendula officinalis (0.32 mL), and Panax ginseng (0.20 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to skin blemishes.
Aqueous ethanol extracts of Arctium lappa (0.32 mL), Echinacea purpurea (0.40 mL), Stellaria media (0.32 mL), Matricaria recutita (0.32 mL), Hypericum perforatum (0.20 mL), and Calendula officinalis (0.20 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to skin burns.
Aqueous ethanol extracts of Symphytum officinale (0.40 mL), Echinacea purpurea (0.20 mL), Aloe vera (0.32 mL), Matricaria recutita (0.32 mL), Hypericum perforatum (0.32 mL), Calendula officinalis (0.32 mL), and Panax ginseng (0.40 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to eczema.
Aqueous ethanol extracts of Equisetum arvense (0.32 mL), Rumex crispus (0.32 mL), Arctium lappa (0.08 mL), Trifolium pratense (0.40 mL), Chelidonium majus (0.08 mL), Thuja occidentalis (0.08 mL), Urtica dioica (0.20 mL), Symphytum officinale (0.32 mL), Mahonia aquifolium (0.32 mL), Echinacea purpurea (0.20 mL), Stellaria media (0.40 mL), Galium aparine (0.40 mL), Aloe vera (0.32 mL), Matricaria recutita (0.32 mL), Hypericum perforatum (0.20 mL), Calendula officinalis (0.20 mL), and Panax ginseng (0.32 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to cuts.
Aqueous ethanol extracts of Equisetum arvense (0.32 mL), Symphytum officinale (0.40 mL), Echinacea purpurea (0.32 mL), Stellaria media (0.20 mL), Aloe vera (0.32 mL), Matricaria recutita (0.20 mL), Hypericum perforatum (0.20 mL), Calendula officinalis (0.40 mL), and Panax ginseng (0.40 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to Tinea pedis (Athlete's Foot).
Aqueous ethanol extracts of Chelidonium majus (0.12 mL), Thuja occidentalis (0.32 mL), Echinacea purpurea (0.20 mL), Galium aparine (0.40 mL), Matricaria recutita (0.40 mL), Hypericum perforatum (0.20 mL), and Calendula officinalis (0.40 mL), were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to sunburn.
Aqueous ethanol extracts of Galium aparine (0.32 mL), Aloe vera (0.40 mL), Matricaria recutita (0.32 mL), Hypericum perforatum (0.40 mL), Calendula officinalis (0.40 mL), and Panax ginseng (0.32 mL), were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to moles.
Aqueous ethanol extracts of Chelidonium majus (0.20 mL), Thuja occidentalis (0.40 mL), Mahonia aquifolium (0.20 mL), Aloe vera (0.20 mL), Matricaria recutita (0.20 mL), and Calendula officinalis (0.40 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to insect bites.
Aqueous ethanol extracts of Arctium lappa (0.32 mL), Urtica dioica (0.40 mL), Echinacea purpurea (0.40 mL), Stellaria media (0.32 mL), Matricaria recutita (0.20 mL), Hypericum perforatum (0.32 mL), and Calendula officinalis (0.40 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to irritant diaper dermatitis.
Aqueous ethanol extracts of Urtica dioica (0.32 mL), Symphytum officinale (0.40 mL), Echinacea purpurea (0.32 mL), Stellaria media (0.32 mL), Aloe vera (0.40 mL), Matricaria recutita (0.40 mL), and Calendula officinalis (0.40 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for use in the treatment of contact dermatitis related to incontinence.
Aqueous ethanol extracts of Urtica dioica (0.32 mL), Symphytum officinale (0.40 mL), Mahonia aquifolium (0.20 mL), Echinacea purpurea (0.40 mL), Stellaria media (0.32 mL), Aloe vera (0.32 mL), Matricaria recutita (0.40 mL), Hypericum perforatum (0.32 mL), Calendula officinalis (0.32 mL), and Panax ginseng (0.40 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to the skin of household pets.
Aqueous ethanol extracts of Rumex crispus (0.32 mL), Arctium lappa (0.32 mL), Trifolium pratense (0.32 mL), Symphytum officinale (0.20 mL), Echinacea purpurea (0.32 mL), Stellaria media (0.20 mL), Hypericum perforatum (0.20 mL), Calendula officinalis (0.20 mL), and Panax ginseng (0.20 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition suitable to be provided in combination with a form of application, such as a porous sheet impregnated with the composition.
Aqueous ethanol extracts of Urtica dioica (0.20 mL), Symphytum officinale (0.40 mL), Echinacea purpurea (0.32 mL), Stellaria media (0.32 mL), Aloe vera (0.40 mL), Matricaria recutita (0.40 mL), and Calendula officinalis (0.40 mL), were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a composition. A porous sheet was treated with the resulting composition to provide a porous sheet impregnated with the composition (a “wet wipe”).
This is an example of a composition suitable to be provided in combination with a form of application, such as a porous sheet impregnated with the composition, wherein the composition is suitable for use with household pets.
Rumex crispus (0.32 mL), Arctium lappa (0.32 mL), Trifolium pratense (0.32 mL), Symphytum officinale (0.20 mL), Echinacea purpurea (0.32 mL), Stellaria media (0.20 mL), Matricaria recutita (0.20 mL), and Calendula officinalis (0.20 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a composition. A porous sheet was treated with the resulting composition to provide a porous sheet impregnated with the composition (a “wet wipe”).
Examples 29 to 42 provide topically applicable compositions comprising plant tinctures prepared by extracting plant material with aqueous ethanol in a ratio of 1:3 weight/volume plant material to aqueous ethanol. The proportion of ethanol to water in the aqueous ethanol (i.e. the ethanol content) for each extract is that as given in Table 1 hereinabove.
This is an example of a composition for applying to blisters.
Aqueous extracts of Equisetum arvense (0.60 mL), Symphytum officinale (0.40 mL), Mahonia aquifolium (0.60 mL), Matricaria recutita (0.60 mL), Hypericum perforatum (0.40 mL), Calendula officinalis (0.60 mL), and Panax ginseng (0.20 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to skin blemishes.
Aqueous extracts of Arctium lappa (0.60 mL), Echinacea purpurea (0.40 mL), Stellaria media (0.60 mL), Matricaria recutita (0.60 mL), Hypericum perforatum (0.40 mL), and Calendula officinalis (0.40 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to skin burns.
Aqueous extracts of Symphytum officinale (0.80 mL), Echinacea purpurea (0.40 mL), Aloe vera (0.60 mL), Matricaria recutita (0.60 mL), Hypericum perforatum (0.60 mL), Calendula officinalis (0.60 mL), and Panax ginseng (0.80 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to eczema.
Aqueous extracts of Equisetum arvense (0.60 mL), Rumex crispus (0.60 mL), Arctium lappa (0.04 mL), Trifolium pratense (0.80 mL), Chelidonium majus (0.04 mL), Thuja occidentalis (0.04 mL), Urtica dioica (0.40 mL), Symphytum officinale (0.60 mL), Mahonia aquifolium (0.60 mL), Echinacea purpurea (0.20 mL), Stellaria media (0.80 mL), Galium aparine (0.80 mL), Aloe vera (0.60 mL), Matricaria recutita (0.60 mL), Hypericum perforatum (0.40 mL), Calendula officinalis (0.40 mL), and Panax ginseng (0.60 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to cuts.
Aqueous extracts of Equisetum arvense (0.60 mL), Symphytum officinale (0.80 mL), Echinacea purpurea (0.60 mL), Stellaria media (0.40 mL), Aloe vera (0.60 mL), Matricaria recutita (0.40 mL), Hypericum perforatum (0.40 mL), Calendula officinalis (0.80 mL), and Panax ginseng (0.80 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to Tinea pedis (Athlete's Foot).
Aqueous extracts of Chelidonium majus (0.20 mL), Thuja occidentalis (0.60 mL), Echinacea purpurea (0.40 mL), Galium aparine (0.40 mL), Matricaria recutita (0.40 mL), Hypericum perforatum (0.40 mL), and Calendula officinalis (0.80 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to sunburn.
Aqueous extracts of Galium aparine (0.60 mL) Aloe vera (0.80 mL), Matricaria recutita (0.60 mL), Hypericum perforatum (0.80 mL), Calendula officinalis (0.80 mL), and Panax ginseng (0.60 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to moles.
Aqueous extracts of Chelidonium majus (0.40 mL), Thuja occidentalis (0.80 mL), Mahonia aquifolium (0.20 mL), Aloe vera (0.20 mL), Matricaria recutita (0.20 mL), and Calendula officinalis (0.80 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to insect bites.
Aqueous extracts of Arctium lappa (0.60 mL), Urtica dioica (0.80 mL), Echinacea purpurea (0.80 mL), Stellaria media (0.60 mL), Matricaria recutita (0.40 mL), Hypericum perforatum (0.60 mL), and Calendula officinalis (0.60 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to Irritant diaper dermatitis.
Aqueous extracts of Urtica dioica (0.60 mL), Symphytum officinale (0.80 mL), Echinacea purpurea (0.60 mL), Stellaria media (0.60 mL), Aloe vera (0.80 mL), Matricaria recutita (0.80 mL), and Calendula officinalis (0.80 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for use in the treatment of contact dermatitis related to incontinence.
Aqueous extracts of Urtica dioica (0.60 mL), Symphytum officinale (0.80 mL), Mahonia aquifolium (0.40 mL), Echinacea purpurea (0.80 mL), Stellaria media (0.60 mL), Aloe vera (0.60 mL), Matricaria recutita (0.80 mL), Hypericum perforatum (0.60 mL), Calendula officinalis (0.60 mL), and Panax ginseng (0.80 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition for applying to the skin of household pets.
Aqueous extracts of Rumex crispus (0.60 mL), Arctium lappa (0.60 mL), Trifolium pratense (0.60 mL), Symphytum officinale (0.40 mL), Echinacea purpurea (0.60 mL), Stellaria media (0.40 mL), Hypericum perforatum (0.40 mL), Calendula officinalis (0.40 mL), and Panax ginseng (0.40 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a topically applicable composition.
This is an example of a composition suitable to be provided in combination with a form of application, such as a porous sheet impregnated with the composition.
Aqueous extracts of Urtica dioica (0.60 mL), Symphytum officinale (0.80 mL), Echinacea purpurea (0.60 mL), Stellaria media (0.60 mL), Aloe vera (0.80 mL), Matricaria recutita (0.80 mL), and Calendula officinalis (0.80 mL), were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a composition. A porous sheet was treated with the resulting composition to provide a porous sheet impregnated with the composition (a “wet wipe”).
This is an example of a composition suitable to be provided in combination with a form of application, such as a porous sheet impregnated with the composition, wherein the composition is suitable for use with household pets.
Aqueous extracts of Rumex crispus (0.60 mL), Arctium lappa (0.60 mL), Trifolium pratense (0.60 mL), Symphytum officinale (0.40 mL), Echinacea purpurea (0.60 mL), Stellaria media (0.40 mL), Matricaria recutita (0.40 mL), and Calendula officinalis (0.40 mL) were combined in a vessel. The extract combination was then made up to 100 mL by the addition of 5 ppm aqueous colloidal silver to provide a composition. A porous sheet was treated with the resulting composition to provide a porous sheet impregnated with the composition (a “wet wipe”).
A composition consisting of aqueous extracts of Equisetum arvense, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng in a ratio of 3:4:3:2:3:2:2:4:4 (w/w) in 5 ppm aqueous colloidal silver was prepared (corresponding to Example 33). The area of skin 120 containing the wound was selected, and the composition topically applied to the selected area. Said composition was regularly applied to the area 120 through a test period of 8 days.
In another example, a subject 200 presented with a nevi (mole) in a localised area of skin 220. The nevi was roughly circular in shape, had a darker pigmentation compared with the surrounding normal skin tone, and protruded from the surface of the skin. A composition consisting of aqueous extracts of Chelidonium majus, Thuja occidentalis, Mahonia aquifolium, Aloe vera, Matricaria recutita, and Calendula officinalis in a ratio of 2:4:1:1:1:4 (w/w) in 5 ppm aqueous colloidal silver was prepared (corresponding to Example 36). The area of skin 220 containing the nevi was selected, and the composition topically applied to the selected area. Said composition was regularly applied to the selected area through a test period of 95 days.
A composition consisting of aqueous extracts of Arctium lappa, Urtica dioica, Echinacea purpurea, Stellaria media, Matricaria recutita, Hypericum perforatum, and Calendula officinalis, in a ratio of 3:4:4:3:2:3:3 (w/w) in 5 ppm aqueous colloidal silver was prepared (corresponding to Example 37). The areas of skin 320 and 330 presenting with insect bites were selected, and the composition topically applied to the selected areas. Said composition was regularly applied (three times-daily) to the areas 320 and 330 through a test period of 24 hours.
Thus,
A composition consisting of aqueous extracts of Equisetum arvense, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, and Panax ginseng in a ratio of 3:4:3:2:3:2:2:4:4 (w/w) in 5 ppm aqueous colloidal silver was prepared (corresponding to Example 33). The area of skin 420 containing the wound was selected, and the composition topically applied to the selected area. Said composition was regularly applied to the areas 420 for the first 5 days of a test period of 10 days.
The above embodiments are to be understood as illustrative examples of the invention. Further embodiments of the invention are envisaged. It is to be understood that any feature described in relation to any one embodiment may be used alone, or in combination with other features described, and may also be used in combination with one or more features of any other of the embodiments, or any combination of any other of the embodiments. Furthermore, equivalents and modifications not described above may also be employed without departing from the scope of the invention, which is defined in the accompanying claims.
| Number | Date | Country | Kind |
|---|---|---|---|
| 1705140 | Mar 2017 | GB | national |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/GB2018/050869 | 3/29/2018 | WO |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2018/178712 | 10/4/2018 | WO | A |
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| Number | Date | Country | |
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| 20200038315 A1 | Feb 2020 | US |
