Hamid et al., "Induction of nitric oxide synthase in asthma", Lancet, 342, pp. 1510-1513, 1993. |
Eizirik et al., "Cytokines Suppress Human Islet Function Irrespective of Their Effects on Nitric Oxide Generation", J. Clin. Invest., 93, pp. 1968-1974, 1994. |
Chemical Abstracts 109:108420. Von Ritter et al. "Gastric mucosal lesions induced by hemorrhagic shock in baboons. Role of oxygen-derived free radicals.", Dig. Dis. Sci. 33(7), pp. 857-864, 1988. |
Choi, P.M., "Immunomodulator Therapy in Inflammatory Bowel Disease", Digestive Diseases and Sciences, 39 (9), pp. 1885-1892, 1994. |
Rachmilewitz, D., et al. "Enhanced colonic nitirc oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease", Gut, 36(5), pp. 718-723, May 1995. |
Aisaka et al., "N.sup.G -Methylarginine, an Inhibitor of Endothelium-Derived Nitric Oxide Synthesis, is a Potent Pressor Agent in the Guinea Pig: Does Nitric Oxide Regulate Blood Pressure In Vivo?" Biochem. Biophys. Res. Commun. 160(2):881-886 (1989). |
Aisaka et al., "L-Arginine Availability Determines the Duration of Acetylcholine-Induced Systemic Vasodilation In Vivo" Biochem. Biophys. Res. Commun. 163(2):710-717 (1989). |
Akaike et al., "Therapeutic Effects of Imidazolineoxyl N-Oxide Against Endotoxin Shock Through Its Direct Nitric Oxide-Scavenging Activity" Biochem. Biophys. Res. Commun. 202(2):923-930 (1994). |
Alving et al., "Increased Amount of Nitric Oxide in Exhaled Air of Asthmatics" Eur. Respir. J. 6:1368-1370 (1993). |
Balter, Michael, "Cytokines Move From the Margins Into the Spotlight" Science 268:205-206 (1995). |
Barnes and Liew, "Nitric Oxide and Asthmatic Inflammation" Immunology Today 16(3):128-130 (1995). |
Boughton-Smith et al., "Nitric Oxide Synthase Activity in Ulcerative Colitis and Crohn's Disease" Lancet 342:338-340 (1993). |
Bredt and Snyder, "Nitric Oxide: A Physiologic Messenger Molecule" Ann. Rev. Biochem. 63:175-95 (1994). |
Bukrinsky et al., "Regulation of Nitric Oxide Synthase Activity in Human Immunodeficiency Virus Type 1 (HIV-1)-infected Monocytes: Implications for HIV-associated Neurological Disease" J. Exp. Med. 181:735-745 (1995). |
Cattell et al., "Localization of Inducible Nitric Oxide Synthase in Acute Renal Allograft Rejection in the Rat" Transplantation 58(12):1399-1402 (1994). |
Claria et al., "Pathogenesis of Arterial Hypotension in Cirrhotic Rats with Ascites: Role of Endogenous Nitric Oxide" Hepatology 15:343-349 (1992). |
Corbett et al., "Nitric Oxide Mediates Cytokine-Induced Inhibition of Insulin Secretion by Human Islets of Langerhans" Proc. Natl. Acad. Sci. USA 90:1731-1735 (1993). |
Devlin et al., "Nitric Oxide Generation" Transplantation 58:592-595 (1994). |
Diket et al., "Nitric Oxide Inhibition Causes Intrauterine Growth Retardation and Hind-Limb Disruptions in Rats" Am. J. Obstet. Gynecol. 171:1243-1250 (1994). |
Dorheim et al., "Nitric Oxide Synthase Acitivity is Elevated in Brain Microvessels in Alzheimer's Disease" Biochem. Biophys. Res. Commun. 205:659-665 (1994). |
Eizirik et al., "Major Species Differences Between Humans and Rodents in the Susceptibility to Pancreatic .beta.-Cell Injury" Proc. Natl. Acad. Sci. USA 91:9253-9256 (1994). |
Evans et al., "Inhibition of Nitroc Oxide Synthase in Experimental Gram-Negative Sepsis" J. Infect. Dis. 169:343-349 (1994). |
Evans et al., "Evidence of Increased Nitric Oxide Production in Patients With the Sepsis Syndrome" Circulatory Shock 41:77-81 (1993). |
Farrel et al., "Increased Concentrations of Nitrite in Synovial Fluid and Serum Samples Suggest Increased Nitric Oxide Synthesis in Rheumatic Diseases" Annals of Rhumatic Diseases 51:1219-1222 (1992). |
Glauser et al., "Pathogenesis and Potential Strategies for Prevention and Treatment of Septic Shock: An Update" Clin. Infect. Dis. 18:S205-16 (1994). |
Gomez-Jimenez et al., "L-Agrinine: Nitric Oxide Pathway in Endotoxemia and Human Septic Shock" Critical Care Medicine 23:253-258 (1995). |
Guarner et al., "Increased Serum Nitrite and Nitrate Levels in Patients with Cirrhosis: Relationship to Endotoxemia" Heptology 18:1139-1143 (1993). |
Hamid et al., "Induction of Nitric Oxide Synthase in Asthma" Lancet 342:1510-1513 (1993). |
Harbrecht et al., "Inhibition of Nitric Oxide Sythesis During Endotoxemia Promotes Intrahepatic Thrombosis and an Oxygen Radical-Mediated Hepatic Injury" J. Leuk. Biol. 52:390-394 (1992). |
Henderson et al., "The Effects of Nitric Oxide Ingibition on Regional Hemodynamics During Hyperdynamic Endotoxemia" Arch. Surg. 129:1271-1275 (1994). |
Hibbs et al., "Evidence for Cytokine-Inducible Nitric Oxide Synthesis from L-Arginine in Patients Receiving Interleukin-2 Therapy" J. Clin. Invest. 89:867-877 (1992). |
Hotchkiss et al., "Inhibition of NO Synthesis in Septic Shock" Lancet 339:434-435 (1992). |
Ignarro et al., "Endothelium-Derived Relaxing Factor Produced and Released From Artery and Vein is Nitric Oxide" Proc. Natl. Acad. Sci., USA 84:9265-69 (1987). |
Ignarro, L.J., "Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide" Ann. Rev. Toxicol. 30:535-560 (1990). |
Johnson et al., "Evidence for Increased Nitric Oxide Production in Multiple Sclerosis" Journal of Neurology, Neurosurgery and Phyciatry 58:107 (1995). |
Kaur and Halliwell, "Evidence for Nitric Oxide Mediated Oxidative Damage in Chronic Inflammation" FEBS Letters 350:9-12 (1994). |
Kharitonov et al., "Increased Nitric Oxide in Exhaled Air of Asthmatic Patients" Lancet 343:133-135 (1994). |
Kilbourn et al., "N.sup.G -Methyl-L-Arginine Inhibits Tumor Necrosis Factor-Induced Hypotension: Implications for the Involvement of Nitric Oxide"Proc. Natl. Adac. Sci. 87:3629-3632 (1990). |
Kilbourn et al., "Reversal of Endotoxin-Mediated Shock by N.sup.G -Methyl-L-Arginine, an Inhibitor of Nitric Oxide Synthesis" Biochem. Biophys. Res. Commun. 172:1132-1138 (1990). |
Kilbourn and Griffith, "Overproduction of Nitric Oxide in Cytokine-Mediated and Septic Shock" J. Natl. Cancer Instit. 84:827-831 (1992). |
Kilbourn et al., "Cell-Free Hemoglobin Reverses the Endotoxin-Mediated Hyporesponsivity of Rat Aortic Rings to .alpha.-Adrenergic Agents" Biochem. Biophys. Res. Commun. 199:155-162 (1994). |
Kilbourn et al., "N.sup.G -Methyl-L-Arginine, an Inhibitor of Nitric Oxide Formation, Reverses IL-2-Mediated Hypotension in Dogs" J. Appl. Physiol. 76:1130-1137 (1994). |
Kim et al., "Loss an Degradation of Enzyme-Bound Heme Induced by Cellular Nitric Oxide Sythesis" J. Biol. Chem. 270:5710-5713 (1995). |
Komarov et al., "In Vivo Spin Trapping of Nitric Oxide in Mice" Biochem. Biophys. Res. Commun. 195:1191-1198 (1993). |
Komarov and Lai, "Detection of Nitric Oxide Production in Mice by Spin-Trapping Electron Paramagnetic Resonance Spectroscopy" Biochimica et Biophysica Acta 1272:29-36 (1995). |
Konturek et al., "Inhibition of Nitric Oxide Synthase Delays Healing of Chronic Gastric Ulcers" Eur. J. Pharmacol. 239:215-217 (1993). |
Kovacs et al., "Increases in CD4 T Lymphocytes with Intermittent Courses of Interleukin-2 in Patients with Human Immunodeficiency Virus Infection" New Eng. J. Med. 332:567-575 (1995). |
Lai and Komarov, "Spin Trapping of NItric Oxide Produced in vivo in Septic-Shock Mice" FEBS Lett. 345:120-124 (1994). |
Lowenstein and Snyder, "Nitric Oxide, A Novel Biologic Messenger" Cell 70:705-707 (1992). |
Lundberg et al., "Greatly Increased Luminal Nitric Oxide in Ulcerative Colitis" Lancet 344:1673-1674 (1994). |
Luss et al., "Inhibition of Nitric Oxide Synthesis Enhances the Expression of Inducible Nitric Oxide Sythase mRNA and Protein in a Model of Chronic Liver Inflammation" Biochem. Biophys. Res. Commun. 204:635-640 (1994). |
Middleton et al., "Increased Nitric Oxide Synthesis in Ulcerative Colitis" Lancet 341:465-466 (1993). |
Miles et al., "Association Between Biosynthesis of Nitric Oxide and Changes in Immunological and Vascular Parameters in Patients Treated with Interleukin-2" Eur. J. Clin. Invest. 24:287-290 (1994). |
Minnard et al., "Inhibition of Nitric Oxide Synthesis Is Detrimental During Endotoxemia" Arch. Surg. 129:142-148 (1994). |
Mitaka et al., "Effects of Nitric Oxide Synthase Inhibitor on Hemodynamic Change and O.sub.2 Delivery in Septic Dogs" Am. J. Physiol. 268:H2017-H2023 (1994). |
Moncada, S., "The 1991 Ulf von Euler Lecture: The L-Arginine: Nitric Oxide Pathway" Acta Physiol. Scand. 145:201-227 (1992). |
Moncada and Higgs, "The L-Arginine-Nitric Oxide Pathway" New Eng. J. Med. 329:2002-2012 (1993). |
Ochoa et al., "Nitrogen Oxide Levels in Patients After Trauma and During Sepsis" Ann. Surg. 214:621-626 (1991). |
Ogle and Qiu, "Nitric Oxide Inhibition Intensifies Cold-Restraint Induced Gastric Ulcers in Rats" Experientia 49:304-307 (1993). |
Palmer, Richard M. J., "The discovery of Nitric Oxide in the Vessel Wall" Arch. Surg. 128:396-401 (1993). |
Palmer et al., "Nitric Oxide Release Accounts for the Biological Activity of Endothelium-Derived Relaxing Factor" Nature 327:524-26 (1987). |
Petros et al., "Effects of a Nitric Oxide Synthase Inhibitor in Humans with Septic Shock" Cardiovascular Research 28:34-39 (1994). |
Petros et al., "Effect of Nitric Oxide Synthase Inhibitors on Hypotension in Patients with Septic Shock" Lancet 338:1557-1558 (1991). |
Qazi et al., "Phase I Clinical and Pharmacokinetic Study of Diethyldithiocarbamate as a Chemoprotector From Toxic Effects of Cisplatin" J. Natl. Cancer Inst. 80:1486-1488 (1988). |
Rachmilewitz et al., "Enhanced Gastric Nitric Oxide Synthase Activity in Duodenal Ulcer Patients" Gut 35:1394-1397 (1994). |
Radomski & Moncada "Regulation of Vascular Homeostatsis by Nitric Oxide" Thromb. Haemos. 70:36-41 (1993). |
Rees et al., "Role of Endothelium-Derived Nitric Oxide in the Regulation of Blood Pressure" Proc. Natl. Acad. Sci. USA 86:3375-3379 (1989). |
Robertson et al., "Detrimental Hemodynamic Effects of Nitric Oxide Synthase Inhibition in Septic Shock" Arch. Surg. 129:149-156 (1994). |
Rodeberg et al., "Nitric Oxide: An Overview" Am. J. Surg. 170:292-303 (1995). |
Schilling et al., "A New Approach in the Treatment of Hypotension in Human Septic Shock by N.sup.G -Monomethyl-L-Arginine, an Inhibitor of the Nitric Oxide Synthetase" Intensive Care Medicine 19:227-231 (1993). |
Shinobu et al. "Sodium N-Methyl-D-Glucamine Dithiocarbamate and Cadmium Intoxication" Acta Pharmacol. Toxicol. 54:189-194 (1984). |
St. John and Dorinsky, "Immunologic Therapy for ARDS, Septic Shock, and Multiple-Organ Failure" Chest 103:932-943 (1993). |
Statman et al., "Nitric Oxide Inhibition in the Treatment of the Sepsis Syndrome is Detrimental to Tissue Oxygenation" J. Surg. Res. 57:93-98 (1994). |
Stefanovic-Racic et al., "Nitric Oxide and Arthritis" Arthrities and Rhumastism 36:1036-1044 (1993). |
Stefanovic-Racic et al., "N-Monomethyl Arginine, an Inhibitor of Nitric Oxide Synthase, Suppresses the Development of Adjuvant Arthritis in Rats" Arhtritis & Rhumatism 37:1062-1069 (1994). |
Vallance and Moncada, "Hyperdynamic Circulation in Cirrhosis: a Role for Nitric Oxide?" Lancet 337:776-778 (1991). |
Vallance and Moncada, "Nitric Oxide--From Mediator to Medicines" Journal of the Royal College of Physicians of London 28:209-219 (1994). |
Waage & Steinshamn, "Cytokine Mediators of Septic Infections in the Normal and Granulocytopenic Host" Eur. J. Haematol. 50:243-249 (1993). |
Winlaw et al., "Urinary Nitrate Excretion is a Noninvasive Indicator of Acute Cardiac Allograft Rejection and Nitric Oxide Production in the Rat" Transplantation 58:1031-1036 (1994). |
Worrall et al., "Modulation of In Vivo Alloreactivity by Inhibition of Inducible Nitric Oxide Synthase" J. Exp. Med. 181:63-70 (1995). |
Yang et al., "Induction of Myocardial Nitric Oxide Synthase by Cardiac Allograft Rejection" J. Clin. Invest. 94:714-721 (1994). |
Zweier et al., "Direct Measurement of Nitric Oxide Generation in the Ischemic Heart Using Electron Paramagnetic Resonance Spectorscopy" J. Bio. Chem. 270:304-307 (1995). |
Von Ritter et al., "Gastric Mucosal Lesions are Induced by Hemorrhagic Shock in Baboons. Role of Oxygen-derived Free Radicals", Digestive Diseases and Sciences, 33(7):857-864 (1988). |