Claims
- 1. A compound of the formula: ##STR133## wherein: S is a solid support
- R.sup.16 is lower alkyl, substituted lower alkyl, aryl, or substituted aryl;
- R.sup.17 is H; alkyl; substituted heterocycloalkyl; alkyl substituted by 1-3 alkoxy, S-loweralkyl, sulfamoyl, halo, alkylsulphonamido, or arylsulphonamido; alkenyl; alkynyl; aryl; substituted aryl; heteroaryl; substituted heteroaryl; heterocycloalkyl; --CH.sub.2 SC(O)R.sup.16 ; --CH.sub.2 NR.sup.16 C(O)R.sup.16 ; --C(O)NR.sup.16 R.sup.16 ; or --CH.sub.2 OC(O)R.sup.16 ;
- R is H or alkyl; and
- Y is aryl or heteroaryl.
- 2. A compound of the formula: ##STR134## wherein: S is a solid support;
- R.sup.16 is lower alkyl, substituted lower alkyl, aryl, or substituted aryl; and
- R.sup.17 is H; alkyl; substituted heterocycloalkyl; alkyl substituted by 1-3 alkoxy, S-loweralkyl, sulfamoyl, halo, alkylsulphonamido, or arylsulphonamido; alkenyl; alkynyl; aryl; substituted aryl; heteroaryl; substituted heteroaryl; heterocycloalkyl; --CH.sub.2 SC(O)R.sup.16 ; --CH.sub.2 NR.sup.16 C(O)R.sup.16 ; --C(O)NR.sup.16 R.sup.16 ; or --CH.sub.2 OC(O)R.sup.16.
- 3. A compound of the formula: ##STR135## wherein: S is a solid support;
- R.sup.16 is lower alkyl, substituted lower alkyl, aryl, or substituted aryl;
- R.sup.17 is H; alkyl; substituted heterocycloalkyl; alkyl substituted by 1-3 alkoxy, S-lower alkyl, sulfamoyl, halo, alkylsulphonamido, or arylsulphonamido; alkenyl; alkynyl; aryl; substituted aryl; heteroaryl; substituted heteroaryl; --CH.sub.2 SC(O)R.sup.16 ; --CH.sub.2 NR.sup.16 C(O)R.sup.16 ; --C(O)NR.sup.16 R.sup.16 ; or --CH.sub.2 OC(O)R.sup.16 ;
- R.sup.18 is H or (CH.sub.2).sub.0-5 R.sup.17 ;
- R is H or alkyl; and
- Y is aryl or heteroaryl.
- 4. A compound of the formula: ##STR136## wherein S is a solid support;
- R.sup.16 is lower alkyl, substituted lower alkyl, aryl, or substituted aryl;
- R.sup.17 is H; alkyl; substituted heterocycloalkyl; alkyl substituted by 1-3 alkoxy, S-loweralkyl, sulfamoyl, halo, alkylsulphonamido, or arylsulphonamido; alkenyl; alkynyl; aryl; substituted aryl; heteroaryl; substituted heteroaryl; heterocycloalkyl; substituted heterocycloalkyl; --CH.sub.2 SC(O)R.sup.16 ; --CH.sub.2 NR.sup.16 C(O)R.sup.16 ; --C(O)NR.sup.16 R.sup.16 ; or --CH.sub.2 OC(O)R.sup.16 ; and
- R.sup.18 is H or (CH.sub.2).sub.0-5 R.sup.17.
- 5. A compound of the formula: ##STR137## wherein: R.sup.16 is lower alkyl, substituted lower alkyl, aryl, or substituted aryl;
- R.sup.17 is H; alkyl; substituted heterocycloalkyl; alkyl substituted by 1-3 alkoxy, S-loweralkyl, sulfamoyl, halo, alkylsulphonamido, or arylsulphonamido; alkenyl; alkynyl; aryl; substituted aryl; heteroaryl; substituted heteroaryl; heterocycloalkyl; substituted heterocycloalkyl; --CH.sub.2 SC(O)R.sup.16 ; --CH.sub.2 NR.sup.16 C(O)R.sup.16 ; --C(O)NR.sup.16 R.sup.16 ; or --CH.sub.2 OC(O)R.sup.16 ;
- R.sup.18 is H or (CH.sub.2).sub.0-5 R1.sup.7 ;
- R is H or alkyl; and
- Y is aryl or heteroaryl.
Parent Case Info
This is a continuation in part of U.S. Ser. No. 08/436,120, filed May 8, 1995, abandoned, which is a continuation in part of U.S. Ser. No. 08/239,302, filed May 6, 1994, abandoned.
Non-Patent Literature Citations (2)
Entry |
Cohen et al., "3,4-Dihydro-2H-1-benzopyran-2-carboxylic Acids and Related Compounds as Leukotriene Antagonists", Journal of Medicinal Chemistry, 1989, vol. 32, No. 8, pp. 1842-1860. |
Harada et al., "Preparation of spirobenzopyran compounds useful in inhibiting biosynthesis and accelerating the excretion of uric acid", Chem. Abstracts, vol. 115, No. 7, Aug. 19, 1991, p. 774 col. 2. |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
436120 |
May 1995 |
|
Parent |
239302 |
May 1994 |
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