Claims
- 28. A device comprising:
- 29. The device according to claim 28, wherein the smallest lateral dimension is a diameter.
- 30. The device according to claim 28, wherein the smallest lateral dimension is measured from one edge of the microelectrode to an opposite edge of the microelectrode.
- 31. The device according to claim 28, wherein each microelectrode is separated from other microelectrodes of the device by a distance of at least twenty times the smallest lateral dimension of the electrode.
- 32. The device according to claim 28, wherein the smallest lateral dimension of one or more of the microelectrodes is less than 100 μm.
- 33. The device according to claim 32, wherein the smallest lateral dimension of each of the microelectrodes of the device is the same.
- 34. The device according to claim 28, wherein the smallest lateral dimension of one or more of the microelectrodes is 0.1 μm to 1 μm.
- 35. The device according to claim 34, wherein the smallest lateral dimension of each of the microelectrodes is the same.
- 36. The device according to claim 28, wherein the conductive matrix comprises a redox polymer.
- 37. The device according to claim 36, wherein the redox polymer comprises a transition metal, and wherein the transition metal is osmium, ruthenium, iron, copper or cobalt.
- 38. The device according to claim 36 wherein the redox polymer comprises a hydrogel.
- 39. The device according to claim 28 wherein the conductive matrix comprises a polycation.
- 40. The device according to claim 28 wherein the conductive matrix has a thickness of 3 nm to 20 μm.
- 41. The device according to claim 28, wherein the functional reactive groups are independently selected from amines, aldehydes, carboxylic acids, or active esters.
- 42. The device according to claim 28 further comprising one or more reference electrodes.
- 43. The device according to claim 28 further comprising one or more counter-electrodes.
- 44. A method for selective synthesis of an array of compounds, the method comprising steps of:
- 45. The method according to claim 44, further comprising repeating the step of selectively applying to one or more microelectrodes a potential sufficient to cause a faradaic reaction in the immediate vicinity of the one or more microelectrodes to induce binding of an additional reactant to form an array of compounds.
- 46. The method according to claim 44, further comprising selectively applying to one or more microelectrodes a potential sufficient to cause a faradaic reaction in the immediate vicinity of the one or more microelectrodes to induce binding of a second reactant to the first reactant.
- 47. The method according to claim 44, wherein the faradaic reaction causes a chemical change in one or more of the functional reactive groups, the reactant, or a chemical species, in the immediate vicinity of the microelectrode.
- 48. The method according to claim 47, wherein the chemical change is a change in ionic concentration or an oxidation or a reduction of the functional reactive groups, the reactant, or the chemical species.
- 49. The method according to claim 48 wherein the change in ionic concentration is a change in pH.
- 50. The method according to claim 48, further comprising providing an enzyme, wherein the chemical change is a change in ionic concentration, and wherein adjustment of the ionic concentration in the immediate vicinity of the microelectrode modulates activity of the enzyme in the immediate vicinity of the microelectrode.
- 51. The method according to claim 44 wherein the reactant comprises a nucleotide.
- 52. The method according to claim 44 wherein the reactant comprises an amino acid.
- 53. The method according to claim 44 wherein the reactant comprises an organic compound, an inorganic compound or a metal-organic ion.
- 54. The method according to claim 53 wherein the organic compound is ascorbic acid or benzoquinone.
- 55. The method according to claim 53 wherein the inorganic compound is iron, cobalt, ruthenium, osmium or copper.
- 56. The method according to claim 44 wherein the method comprises:
- 57. The method according to claim 56 further comprising:
- 58. The method according to claim 56 wherein the step of selectively applying to one or more microelectrodes a current or potential sufficient to cause a faradaic reaction in the immediate vicinity of the one or more microelectrodes induces binding of the first nucleotide to one or more of the amine reactive groups.
- 59. A method for selective synthesis of an array of compounds, the method comprising steps of:
- 60. The method according to claim 59 further comprising repeating the step of selectively applying to one or more microelectrodes a potential sufficient to cause a faradaic reaction in the immediate vicinity of the microelectrode to induce deposit of a second metal onto the microelectrode to synthesize a non-stoichiometric inorganic compound or metal alloy on the microelectrode.
- 61. The method according to claim 59 further comprising the step of inducing etching or dissolution of a portion of one or more metals deposited onto the microelectrode.
- 62. The method according to claim 61 further comprising reacting by heating, oxidation, sulfidation, or consolidation to form an alloy or non-stoichiometric inorganic compound.
- 63. A method for selective synthesis of an array of compounds, the method comprising steps of:
Cross Reference to Related Applications
[0001] This application is a continuation application of PCT Application No. PCT/US99/14459 A1, which claims priority to Provisional Patent Application Serial No. 60/090,520, which applications are hereby incorporated for all purposes.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/090,520 |
Jun 1998 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/US99/14459 |
Jun 1999 |
US |
Child |
09746840 |
Dec 2000 |
US |