The present application claims priority from Australian Provisional Patent Application No 2003907149 filed on 24 Dec. 2003 and Australian Provisional Patent Application No 2004900216 filed on 16 Jan. 2004, the contents of which are incorporated herein by reference.
1. Field of the Invention
The present invention relates to cochlear prostheses, and in particular to electrical stimulation of the auditory nerve by an implanted cochlear prosthesis in a manner which produces an improved sound percept for the recipient of the prosthesis.
2. Related Art
Cochlear implants have been developed to assist people who are profoundly deaf or severely hearing impaired, by enabling them to experience a hearing sensation representative of the natural hearing sensation. For most such individuals the hair cells in the cochlea, which normally function to transduce acoustic signals into nerve impulses which are interpreted by the brain as sound, are absent or have been destroyed. The cochlear implant therefore bypasses the hair cells to directly deliver electrical stimulation to the auditory nerve with this electrical stimulation being representative of the sound.
Cochlear implants have traditionally consisted of two parts, an external speech processor unit and an implanted receiver/stimulator unit. The external speech processor unit has been worn on the body of the user and its main purpose has been to detect the external sound using a microphone and convert the detected sound into a coded signal through an appropriate speech processing strategy.
This coded signal is then sent to the receiver/stimulator unit which is implanted in the mastoid bone of the user, via a transcutaneous link. The receiver/stimulator unit processes the coded signal into a series of stimulation sequences which are then applied directly to the auditory nerve via a series or an array of electrodes positioned within the cochlea, proximal to the modiolus of the cochlea. One such cochlear implant is set out in U.S. Pat. No. 4,532,930, the contents of which are incorporated herein by reference.
With improvements in technology it is possible that the external speech processor and implanted stimulator unit may be combined to produce a totally implantable cochlear implant unit that is capable of operating, at least for a period of time, without the need for any external device. In such a device, a microphone would be implanted within the body of the user, for example in the ear canal or within the stimulator unit, and sounds would be detected and directly processed by a speech processor within the stimulator unit, with the subsequent stimulation signals delivered without the need for any transcutaneous transmission of signals. Such a device would, however, still have the capability to communicate with an external device when necessary, particularly for program upgrades and/or implant interrogation, and if the operating parameters of the device required alteration.
Much effort has been dedicated to developing suitable stimulations to be applied by such cochlear implants. Currently employed stimulation techniques, such as the SPEAK, CIS and ACE™ strategies employed by Cochlear Ltd, use selected electrodes of the implanted electrode array to apply square biphasic pulses.
In the SPEAK strategy as described for example in U.S. Pat. No. 5,597,380, the amplitude of numerous frequency bands in the audible range (for example 16 or 20 frequency bands) are determined. A subset of electrodes of the electrode array is tonotopically selected to apply biphasic pulses to selected parts of the cochlea, based on those frequency bands which have the largest amplitude. For example, every 4 ms the six frequency bands having the largest amplitude may be chosen, with six corresponding electrodes being used to apply stimuli to the cochlea. The stimuli are typically presented sequentially. Thus, regardless of the particular electrodes applying stimuli within any one period, an overall stimulation rate produced by the prosthesis and applied to the cochlea remains constant. This stimulation rate tends to be a moderate rate resulting in the SPEAK stimulation strategy being power efficient.
The CIS strategy uses high stimulation rates, up to 12 channels, and a fixed subset of electrodes of the electrode array. By using high stimulation rates, CIS produces a percept which conveys more detailed timing information of speech, to assist in conveying the rapid timing cues in speech. The choice of channels, electrodes and stimulation rates is customised to each user by empirical testing, or mapping, after the prosthesis has been fitted.
The ACE™ strategy divides audible sound into as many as 22 frequency bands. Each frequency band is used to produce stimulations by a specific electrode along the electrode array, once again based on the tonotopic position of that electrode. The stimulation rate produced by the ACE™ strategy varies and may produce as many as 14,400 pulses per second.
While the stimulation strategies currently employed provide for device customisation in order to produce the best available percepts for the prosthesis recipient, it is nevertheless acknowledged in the cochlear implant field that the percepts produced by pulsatile electrical stimulation are often un-natural sounding and somewhat harsh. Although many patients adapt to this sound and, after some time, even find it natural, this is not always the case and some patients may experience difficulties. In any event it would be desirable to apply a stimulation strategy which produces percepts which sound more natural so that patients are not required to go through a stage of adapting to unnatural sounding percepts.
In some instances, patients have reported that analogue stimulation has a more natural sound. Analogue stimulation however has some disadvantages due primarily to channel interaction effects. For instance, when a number of current sources are used simultaneously the electric fields can sum without control beyond a comfort threshold and produce an excessively loud percept.
Any discussion of documents, acts, materials, devices, articles or the like which has been included in the present specification is solely for the purpose of providing a context for the present invention. It is not to be taken as an admission that any or all of these matters form part of the prior art base or were common general knowledge in the field relevant to the present invention as it existed before the priority date of each claim of this application.
Throughout this specification the word “comprise”, or variations such as “comprises” or “comprising”, will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not the exclusion of any other element, integer or step, or group of elements, integers or steps.
According to a first aspect, the present invention provides a cochlear prosthesis comprising:
According to a second aspect, the present invention provides a method of generating stimuli for a cochlea comprising:
According to a third aspect the present invention provides a speech processor for a cochlear prosthesis, the speech processor comprising:
The stimuli modulated by the modulating signal are preferably at a high rate and amplitude modulated by the modulating signal. Alternatively, the stimuli may be pulse width modulated by the modulating signal.
Preferably, the at least one of the plurality of electrodes by which the high rate stimuli are to be applied is the most apical electrode. Alternatively, the at least one of the plurality of electrodes by which the high rate stimuli are to be applied may be selected based on empirical fitting of the prosthesis following surgical implantation of the prosthesis. The high rate stimuli may be applied by a bipolar pair of electrodes or use one or more intra cochlear electrodes with an extra-cochlear return path.
Preferably, the pulsatile stimuli and the high rate stimuli are applied sequentially, such that only one stimulus is applied by the electrode array at one time. For instance, every second stimulus applied by the electrode array may be a stimulus of the high rate stimuli applied by the at least one of the plurality of electrodes, wherein the pulsatile stimuli make up the remainder of the stimuli applied by the electrode array. Alternatively, every third, fourth or other integer stimulus applied by the electrode array may be a stimulus of the high rate stimuli applied by the at least one of the plurality of electrodes, wherein the pulsatile stimuli make up the remainder of the stimuli applied by the electrode array.
The pulsatile stimuli generated from at least a subset of the channels may be applied in a tonotopic manner such that an electrode to apply each pulsatile stimulus is selected based on tonotopic position of that electrode within the cochlea.
The plurality of frequency channels may comprise 20 frequency channels. The plurality of frequency channels is preferably at substantially even logarithmic spacings throughout a subset of the audible frequency range, for instance, the centre of each frequency channel may be positioned from a low frequency in the range of 120-300 Hz to a high frequency in the range of 5-10 kHz.
Pulsatile stimuli may be generated from those channels which have a large amplitude within a given analysis period. For instance, pulsatile stimuli may be generated based on the six channels of largest amplitude within the analysis period. The channel amplitudes may be obtained by use of a fast Fourier transform (FFT) algorithm. The analysis period may be 4 ms.
The modulating signal may be obtained directly from the received sound signal without processing, or alternatively the received sound signal may be processed in some manner in order to obtain the modulating signal. The modulating signal may be obtained from the received sound signal by band-pass filtering the received sound signal, to exclude components outside a desired frequency range. The desired range may have a lower frequency limit of 340 Hz and a high frequency limit of 2700 Hz. Additionally or alternatively, in obtaining the modulating signal the received sound signal may be compressed, for example to conform to patient threshold and comfort levels of stimulation.
The high rate stimuli may be applied by a plurality of electrodes. In such embodiments, the selection of which electrodes are to be used as high rate electrodes may be based on achieving an appropriate physical distribution of the high rate stimulation.
The plurality of high rate electrodes may be used to physically distribute a single high rate stimulus sequence. For instance, where two high rate electrodes are used to apply the high rate stimuli, one high rate electrode may apply every second high rate stimulus, while the other high rate electrode applies every other high rate stimulus. Similarly, where three high rate electrodes are used to apply the high rate stimuli, a first high rate electrode may apply every third high rate stimulus, a second high rate electrode may apply each following high rate stimulus, and a third high rate electrode may apply each remaining high rate stimulus.
Alternatively, each of the plurality of high rate electrodes may apply a distinct high rate stimulus sequence. In such embodiments, the system preferably comprises means to obtain a plurality of modulating signals from the sound signal, and means to generate a plurality of high rate stimuli, each modulated by one of said modulating signals, whether by amplitude modulation or pulse width modulation. The plurality of modulating signals may comprise modulating signals obtained from distinct frequency components of the sound signal. For instance, three modulating signals may be obtained, comprising a first modulating signal obtained from a low frequency component of the sound signal, a second modulating signal obtained from a medium frequency component of the sound signal, and a third modulating signal obtained from a high frequency component of the sound signal.
In embodiments where the modulating signals have been obtained from distinct frequency components of the sound signal, high rate electrodes to apply each high rate stimulus modulated by one of said modulating signals are preferably selected tonotopically. For example, where three modulating signals are obtained, the high rate electrodes are preferably selected based on their position such that high rate stimuli modulated by the first modulating signal are applied by an apical electrode, high rate stimuli modulated by the third modulating signal are applied by a basal electrode, and high rate stimuli modulated by the second modulating signal are applied by an electrode between the apical electrode and the basal electrode.
The prosthesis may further comprise input processing means, such as one or more of a pre-amplifier, a low pass filter, a bandpass filter, and a speech processing means.
The cochlear prosthesis may comprise 22 electrodes for stimulating the cochlea.
The prosthesis may further comprise user input means enabling a user to control a stimulation strategy. For example the user input means may enable the user to selectively enable high rate modulated stimuli, such as when the user is in a non-speech environment for instance in the presence of music. The user may for example selectively disable high rate modulated stimuli in speech environments should the user thus gain a better speech percept. The user input means may further enable user control of balance between a high rate modulated stimulation strategy and a pulsatile stimulation strategy. Such control may be continuous so as to enable a smooth transition between the strategies in accordance with user preference.
According to a fourth aspect the present invention provides a computer program for generating stimuli for a cochlea comprising:
According to a fifth aspect the present invention provides a computer readable medium having recorded thereon a computer program in accordance with the fourth aspect.
The stimulus commands may comprise radio frequency (RF) frames to be transmitted to an implanted component of an auditory prosthesis.
According to a sixth aspect the present invention provides a method of generating a patient-specific map for a high rate channel of a combined stimulation scheme, the method comprising:
According to a seventh aspect the present invention provides a computer program for generating a patient-specific map for a high rate channel of a combined stimulation scheme, the computer program comprising:
By way of example only, preferred embodiments of the invention will be described with reference to the accompanying drawings, in which:
Before describing the features of the present invention, it is appropriate to briefly describe the construction of a cochlear implant system with reference to
Cochlear implants typically consist of two main components, an external component including a sound processor 29, and an internal component including an implanted receiver and stimulator unit 22. The external component includes an on-board microphone 27. The sound processor 29 is, in this illustration, constructed and arranged so that it can fit behind the outer ear 11. Alternative versions may be worn on the body or it may be possible to provide a fully implantable system which incorporates the speech processor and/or microphone into the implanted stimulator unit. Attached to the sound processor 29 is a transmitter coil 24 which transmits electrical signals to the implanted unit 22 via an RF link.
The implanted component includes a receiver coil 23 for receiving power and data from the transmitter coil 24. A cable 21 extends from the implanted receiver and stimulator unit 22 to the cochlea 12 and terminates in an electrode array 20. The signals thus received are applied by the array 20 to the basilar membrane 8 thereby stimulating the auditory nerve 9. The operation of such a device is described, for example, in U.S. Pat. No. 4,532,930.
The sound processor 29 of the cochlear implant can perform an audio spectral analysis of the acoustic signals and outputs channel amplitude levels. The sound processor 29 can also sort the outputs in order of magnitude, or flag the spectral maxima as used in the SPEAK strategy developed by Cochlear Ltd.
The present invention relates to the combination of the conventional multi-electrode pulsatile paradigms together with a continuous time modulating component.
In one arrangement, the continuous time modulating component is based on a broadband sound signal that modulates a pulsatile carrier, which is then applied to a subset of electrodes. This subset of electrodes is independent of the remaining electrodes, to which conventional pulsatile paradigms are applied.
In another arrangement, the broadband sound signal modulates one or more of a plurality of channels that are generally configured to operate in accordance with conventional pulsatile paradigms.
In another arrangement, a broadband sound signal modulates both a pulsatile carrier that is applied to a subset of electrodes, and one or more of a plurality of channels that are generally configured to operate in accordance with conventional pulsatile paradigms, to the remaining electrodes.
The modulation may be amplitude modulation, pulse width modulation or other form of power modulation conveying the modulating signal.
The amplified detected sound is also passed to a mathematical process 35 which obtains a modulating signal y from the received sound signal x. The modulating signal y is used to amplitude modulate a high rate 7.2 kHz pulse sequence which is mapped by processor 36 and is to be applied by a high rate electrode, in this case being the most apical electrode of the electrode array.
Several alternate embodiments of the invention are possible. For example it would be possible to distribute the region of AM stimulation to a range of electrodes or cochlear places rather than one specific electrode. Thus for example, two or three chosen electrodes would be stimulated, their combined rate being a high rate as in (a) but distributed across these electrodes. As a further alternate, more than one high rate AM carrier may be introduced, each modulated by a different derivative of the acoustic signal, and each receiving more than one pulse per frame. Alternate electrode configurations may also be employed, such as bipolar, tripolar, or arbitrary combinations of electrodes for each channel. It is further to be understood that the pulses employed on any channel need not be rectangular, but may have other shapes as may be advantageous such as sinusoid cycles.
Another embodiment of the present invention is shown in
Furthermore, it is assumed that if the multi-channel speech processing algorithm is one which involves the selection of maxima to determine a subset of electrodes to be activated, then this selection will operate on the output of the envelope detectors rather than the modulated output. The sum of all stimulated electrodes would then appear approximately as shown in Trace (b) of
The input signal may be band-pass or low-pass filtered and then transformed by any mathematical relationship which may be deemed appropriate.
Whilst
Referring to
This combined strategy could be used in a number of ways. In one form, the single channel strategy, which for some users may provide more natural sounding percepts, could be chosen for non-speech situations. The patient could switch to a multiple channel strategy for speech communication. At the other extreme, both strategies could be running simultaneously as described above. As a further option, the patient could have the ability to smoothly vary the mix of the two strategies between the single channel and multiple channel cases.
It will be appreciated by persons skilled in the art that numerous variations and/or modifications may be made to the invention as shown in the specific embodiments without departing from the spirit or scope of the invention as broadly described. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive.
Number | Date | Country | Kind |
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2003907149 | Dec 2003 | AU | national |
2004900216 | Jan 2004 | AU | national |