Claims
- 1. A complex consisting of guanidine and 3'-azido-3'-deoxythymidine (AZT) whose structure is shown below: ##STR8## and whose melting point is 210.9.degree. C.-212.degree. C.
- 2. The complex consisting of guanidine and 3'-azido-3'-deoxythymidine (AZT) prepared by reacting AZT with a reagent selected from the group consisting of guanidine, a combination of a base and guanidine, and mixtures thereof, to form a precipitated complex.
- 3. The complex of claim 2 wherein the precipitating reagent is a solution of guanidine.
- 4. The complex of claim 3 wherein the solution of guanidine is prepared by suspending guanidine hydrochloride in a solvent, adding a base thereto to produce a precipitate and filtering said precipitate to provide a filtrate consisting essentially of the solution of guanidine.
- 5. The complex of claim 4 wherein said base is sodium hydroxide and said precipitate is sodium chloride.
- 6. The complex of claim 4 wherein said solvent is a polar solvent.
- 7. The complex of claim 4 wherein said solvent is ethanol.
- 8. The complex of claim 2 wherein the process for preparing the complex comprises contacting a suspension of AZT with a base to dissolve the AZT yielding a solution having a pH of from about 10 to about 14, and then adding guanidine hydrochloride to the solution.
- 9. The complex of claim 8 wherein said guanidine hydrochloride is in the form of a solid.
- 10. The complex of claim 8 wherein said guanidine hydrochloride is in the form of an aqueous solution.
- 11. The complex of claim 3 wherein said the process is conducted in the presence of a polar solvent.
- 12. The complex of claim 11 wherein the polar solvent is selected from the group consisting of water, methanol, ethanol, isopropanol, methylisobutylketone, and acetone.
CROSS-REFERENCE TO RELATED APPLICATION
This is a Rule 60 continuation of application Ser. No. 07/914,104, filed 16 Jul. 1992, now U.S. Pat. No. 5,387,677, which is a continuation in part of U.S. Ser. No. 07/717,831, filed 21 Jun. 1991, now abandoned.
US Referenced Citations (16)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0217580 |
Apr 1987 |
EPX |
Non-Patent Literature Citations (1)
Entry |
Patthy et al. J. Biol. Chem. 250(2): 557-564, 1975. |
Continuations (2)
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Number |
Date |
Country |
Parent |
914104 |
Jul 1992 |
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Parent |
717831 |
Jun 1991 |
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