Claims
- 1. A new complex derived from platinum, of general formula: ##STR16## in which: R.sub.1 and R.sub.2 together form a saturated or unsaturated polycyclic carbocyclic radical containing 7 to 12 carbon atoms, or a saturated or partially saturated mono-, bi- or tricyclic heterocyclic radical containing 5 to 11 chain members and a hetero-atom chosen from oxygen, sulphur or nitrogen, which latter atom can optionally be substituted by an alkoxycarbonyl radical, and,
- X.sub.1 and X.sub.2 represent chlorine atoms or together form
- either a radical of structure: ##STR17## in which n is 0 to 2 and R.sub.6 and R.sub.7, which are identical or different, are hydrogen atoms or, when n=1, can be alkyl radicals or form, together with the carbon atom to which they are attached, a cyclobutyl radical,
- or a radical of structure: ##STR18## in which n, R.sub.6 and R.sub.7 are defined as above, it being understood that the abovementioned alkyl radicals and portions contain 1 to 4 carbon atoms in a straight or branched chain, and its hydrates and its salts where such exist.
- 2. A new complex derived from platinum according to claim 1, in which R.sub.1 and R.sub.2 together form a saturated polycyclic carbocyclic radical chosen from: bicyclo[2.2.1]heptane, bicyclo[3.2.1.]octane, bicyclo[2.2.2]octane, bicyclo[3.2.2]nonane, bicyclo[3.3.1]nonane, adamantane, decahydronaphthalene, tetrahydronaphthalene, spiro[5.5]undecane, tricyclo[5.2.1.0/2,6]decane or indane, or R.sub.1 and R.sub.2 together form a heterocyclic radical chosen from: 4-chromanyl, 3-coumaryl, 4-homopiperidinyl, 4-piperidinyl, 3-pyrrolidinyl, 3-quinuclidinyl, 4-tetrahydropyranyl, 3-tetrahydrofuryl, 4-tetrahydrothiopyranyl, 3-tetrahydrothiofuryl or 4-tetrahydroquinolyl, and its hydrates and its salts.
- 3. A new complex derived from platinum according to claim 1, in which R.sub.1 and R.sub.2 together form a polycyclic carbocyclic radical chosen from: bicyclo[2.2.1]heptane, adamantane, bicyclo[3.2.1]octane, bicyclo[2.2.2]octane or tricyclo[5.2.1.0/2,6]decane and X.sub.1 and X.sub.2 represent chlorine atoms or a radical of structure: ##STR19## in which n is 1 and R.sub.6 and R.sub.7 are hydrogen atoms or methyl radicals or together form a cyclobutyl radical, and its hydrates and its salts.
- 4. Cis-(2-amino-2-aminomethyl-bicyclo[2.2.1]heptane)dichloroplatinum and its hydrated forms.
- 5. Cis-(2-amino-2-aminomethyl-bicyclo[3.2.1]octane)dichloroplatinum and its hydrated forms.
- 6. Cis-(2-amino-2-aminomethyl-adamantane)dichloroplatinum and its hydrates.
- 7. Cis-(3-amino-3-aminomethyl-bicyclo[3.2.1]octane)dichloroplatinum and its hydrates.
- 8. Cis-(2-amino-2-aminomethyl-bicyclo[2.2.2]octane)dichloroplatinum and its hydrates.
- 9. A pharmaceutical composition, which contains at least one complex derived from platinum according to claim 1, in the pure state, optionally in the form of a salt or hydrate or in combination with any compatible and pharmaceutically acceptable diluent or adjuvant.
Priority Claims (1)
Number |
Date |
Country |
Kind |
89 03511 |
Mar 1989 |
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Parent Case Info
This application is a continuation-in-part of U.S. Ser. No. 07 493,704 filed Mar. 14, 1990, abandoned, which is hereby incorporated by reference.
US Referenced Citations (2)
Number |
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Date |
Kind |
4562275 |
Speer et al. |
Dec 1985 |
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4739087 |
Speer et al. |
Apr 1988 |
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Foreign Referenced Citations (2)
Number |
Date |
Country |
155705 |
Sep 1985 |
EPX |
290169 |
Nov 1988 |
EPX |
Non-Patent Literature Citations (2)
Entry |
Chemical Abstracts, v. 109, No. 15, 10 Oct. 1988, Abst. No. 190186e, Georgiadis, et al. "Products from furans v. Synthesis of oxygen-containing isosteres of sympathomimetic amines via 6-hydroxy-2Hpyran-3(6H)-ones and their cis-platinum(II) complexes". |
"Products from Furans v. Synthesis of Oxygen-Containing Isosteres of Sympathomimetic Amines via 6-Hydroxy-2H-pyran-3(6H)-ones and their cis-Platinum (II) Complexes", Georgiadis et al, J. Heterocyclic Chem. vol. 25, 995 (1988). |
Continuation in Parts (1)
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Number |
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Parent |
493704 |
Mar 1990 |
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