Patent Application
20230090517
The present invention claims priority to Chinese patent application No. 202011538060.0 filed on Dec. 23, 2020 and entitled “Composite quaternary ammonium salt disinfectant and method for preparing the same”, which is incorporated by reference herein in its entirety.
The invention relates to the field of disinfectants, and in particular to a composite quaternary ammonium salt disinfectant and a method for preparing the same.
In recent years, new and sudden enveloped viruses, such as influenza, SARS, Middle East respiratory syndrome, Hog cholera, Ebola, and novel coronavirus, have posed a serious threat to human life and property. In the absence of specific drugs and vaccines, regular disinfection in public places and strengthening personal daily protection have been proved to be one of the effective means to control the rapid spread of novel coronavirus so far.
According to the list of disinfectants against novel coronavirus issued by EPA, a quaternary ammonium salt disinfectant accounts for a large proportion, which is an important disinfectant to combat the epidemic. Quaternary ammonium salts are a class of cationic surfactants, and the common quaternary ammonium salts have the general structural formula as follows:
wherein, R1-R2 represent organic groups, including alkyl, aryl, etc., which combine with a nitrogen atom to form a cationic group serving as an effective bactericidal part, and X is an anion, such as halogen, sulfate, or other analogs. In quaternary ammonium salts serving as disinfectants, R1 is usually an alkyl group with a chain length of C8-C18, and R2 is usually an aryl (for example, benzyl, ethyl benzyl) or alkyl group with a chain length of C8-C18. Quaternary ammonium salts, in which only one of R1 and R2 is long alkyl chain, are called single long-chain quaternary ammonium salts, such as alkyl dimethyl benzyl ammonium chloride and alkyl dimethyl ethyl benzyl ammonium chloride; and quaternary ammonium salts with both R1 and R2 being long alkyl chains are called double long-chain quaternary ammonium salts.
The combination of a traditional double long-chain quaternary ammonium salt and a single long-chain quaternary ammonium salt shows poor killing effect on hydrophilic viruses, and the killing effect of quaternary ammonium salt disinfectants is easily interfered by pollutants, such as hard water and organic pollutants, with the speed of kill needing further improvement.
One object of the invention is to provide a composite quaternary ammonium salt disinfectant and a method for preparing the same. The composite quaternary ammonium salt disinfectant has a synergistic effect among its components, which greatly improves the capacity of resisting interferences by hard water and organics, and can kill not only bacterial propagules, lipophilic viruses (enveloped viruses, such as novel coronavirus) and fungi, but also hydrophilic viruses (non-enveloped viruses). In addition, the composite quaternary ammonium salt disinfectant provided by the invention has a rapid speed of kill.
In order to achieve the object of the invention, the technical solutions provided by the invention are as follows:
A composite quaternary ammonium salt disinfectant is provided, which is prepared from raw materials comprising: a double long-chain quaternary ammonium salt, two single long-chain quaternary ammonium salts, a synergist isothiazolinone, a nonionic surfactant fatty alcohol polyvinyl ether, and water;
the double long-chain quaternary ammonium salt is dialkyl dimethyl ammonium chloride, in which dialkyl is two independent alkyl groups with a chain length of C8-C18; and the two single-chain quaternary ammonium salts are alkyl dimethyl benzyl ammonium chloride with an alkyl chain length of C8-C18 and alkyl dimethyl ethyl benzyl ammonium chloride with an alkyl chain length of C8-C18, respectively.
In one possible embodiment of the composite quaternary ammonium salt disinfectant, the double long-chain quaternary ammonium salt is one or more selected from the group consisting of didecyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, octyl decyl dimethyl ammonium chloride, didodecyl dimethyl ammonium chloride, ditetradecyl dimethyl ammonium chloride, and dihexadecyl dimethyl ammonium chloride; optionally, the double long-chain quaternary ammonium salt is one or more selected from the group consisting of didecyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, octyl decyl dimethyl ammonium chloride, and didodecyl dimethyl ammonium chloride; further optionally, the double long-chain quaternary ammonium salt is one or more selected from the group consisting of didecyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, and octyl decyl dimethyl ammonium chloride.
In one possible embodiment of the composite quaternary ammonium salt disinfectant, alkyl dimethyl benzyl ammonium chloride with an alkyl chain length of C8-C18 is alkyl dimethyl benzyl ammonium chloride with an alkyl chain length of C10-C16, optionally alkyl dimethyl benzyl ammonium chloride with an alkyl chain length of C12-C16, and further optionally dodecyl dimethyl benzyl ammonium chloride;
and/or, alkyl dimethyl ethyl benzyl ammonium chloride with an alkyl chain length of C8-C18 is alkyl dimethyl ethyl benzyl ammonium chloride with an alkyl chain length of C10-C16, optionally alkyl dimethyl ethyl benzyl ammonium chloride with an alkyl chain length of C12-C14. In one possible embodiment of the composite quaternary ammonium salt disinfectant, the mass ratio of the double long-chain quaternary ammonium salt to the two single long-chain quaternary ammonium salts is 1: 0.20-1.0: 0.20-1.0.
In one possible embodiment of the composite quaternary ammonium salt disinfectant, the isothiazolinone is one or more selected from the group consisting of Kathon, 2-methyl-4-isothiazolin-3 -one, 2-octyl-4 -isothiazolin-3 -one, and 1,2-benzisothiazolin-3 -one; and/or, the fatty alcohol polyvinyl ether is AEO9 or AEO10.
In one possible embodiment of the composite quaternary ammonium salt disinfectant, the composite quaternary ammonium salt disinfectant further comprises one or more synergists selected from urotropine and o-phthalaldehyde;
and/or, the composite quaternary ammonium salt disinfectant further comprises one or more nonionic surfactants selected from glycosides, poloxamer, and polyvinyl alcohol. In one possible embodiment of the composite quaternary ammonium salt disinfectant, the total concentration of the double long-chain quaternary ammonium salt and two single long-chain quaternary ammonium salts in the composite quaternary ammonium salt disinfectant ranges from 2.0 g/L to 200 g/L (w/v), optionally from 5.0 g/L to 150 g/L (w/v), and further optionally from 10 g/L to 100 g/L (w/v).
In one possible embodiment of the composite quaternary ammonium salt disinfectant, the content of the synergist ranges from 0.01% to 1.0% (w/w), optionally from 0.02% to 0.5% (w/w), and further optionally from 0.03% to 0.3% (w/w);
and/or, the content of the nonionic surfactant ranges from 1.0% to 20% (w/w), optionally from 1.5% to 15% (w/w), and further optionally from 2.0% to 10% (w/w).
In one possible embodiment of the composite quaternary ammonium salt disinfectant, the composite quaternary ammonium salt disinfectant further comprises a pH modifier and/or alcohols or analogues;
the pH modifier is two or more selected from the group consisting of EDTA-4Na, EDTA-2Na, EDTA, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, sodium dihydrogen phosphate and disodium hydrogen phosphate; optionally, the pH modifier is two or more selected from the group consisting of EDTA-4Na, EDTA-2Na, EDTA, potassium dihydrogen phosphate and dipotassium hydrogen phosphate; further optionally, the pH modifier is selected from two or three of EDTA-4Na, EDTA-2Na and EDTA;
and the alcohols or analogues are one or more selected from the group consisting of ethanol, propanol, isopropanol, dipropylene glycol, dipropylene glycol propyl ether, dipropylene glycol butyl ether, ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, and 1,2-decanediol; optionally, the alcohols or analogues include one or more of ethanol, dipropylene glycol, dipropylene glycol propyl ether, dipropylene glycol butyl ether, ethylene glycol, 1,2 -butanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, and 1,2-decanediol; further optionally, the alcohols or analogues include one or more of ethanol, dipropylene glycol, dipropylene glycol propyl ether, dipropylene glycol butyl ether, 1,2-hexanediol and 1,2-octanediol. In one possible embodiment of the composite quaternary ammonium salt disinfectant, the content of the alcohols or analogues ranges from 0.5% to 15% (w/w), optionally from 0.8% to 10% (w/w), and further optionally from 1.0% to 8% (w/w);
and/or, the content of the pH modifier ranges from 0.2% to 15% (w/w), optionally from 0.5% to 10% (w/w), and further optionally from 2% to 5% (w/w).
The invention also provides a method for preparing the composite quaternary ammonium salt disinfectant, which comprises the steps of dissolving each component in purified water and stirring; optionally, the method further comprises the step of dilution after stirring and dissolving.
(1) The composite quaternary ammonium salt disinfectant provided by the invention is composed of a double long-chain quaternary ammonium salt, two single long-chain quaternary ammonium salts, a synergist and a nonionic surfactant, showing a synergistic effect among the components. The composite quaternary ammonium salt disinfectant provided by the invention has a higher anti-interference capacity compared to the traditional combination of a double long-chain quaternary ammonium salt and a single long-chain quaternary ammonium salt, which greatly improves the capacity of resisting interference by hard water, and can be directly diluted with tap water for using within 72 hours after dilution without affecting the killing capability on microorganisms. The composite quaternary ammonium salt disinfectant provided by the invention also greatly improves the capacity of resisting interference by organics, and can still kill Pseudomonas aeruginosa at the action time of 2 min in the case of interference by 50% calf serum, showing an excellent capacity of resisting interference by organics.
At the same time, the composite quaternary ammonium salt disinfectant provided by the invention can kill not only bacterial propagules, lipophilic viruses (enveloped viruses) and fungi, but also hydrophilic viruses (non-enveloped viruses). In addition, the composite quaternary ammonium salt disinfectant provided by the invention is capable of killing novel coronavirus rapidly in a test. The results show that the composite quaternary ammonium salt disinfectant provided by the invention can also rapidly kill novel coronavirus (2019-nCoV) and coronavirus (GX-P2V) in 30 s, 1 min and 3 min, with the killing logarithmic value being greater than 4.
The composite quaternary ammonium salt disinfectant provided by the invention has a higher speed of kill than the traditional combination of a double long-chain and a single long-chain quaternary ammonium salts.
(2) The composite quaternary ammonium salt disinfectant provided by the invention has the following advantages: easy to use, non-toxic, non-irritative, non-corrosive, resistant to interference by hard water, etc., and can be used for disinfecting various surfaces, air, hands, skin, mucous membranes, etc., as well as water bodies, aquaculture industries and other fields, which is suitable for large-scale promotion. The method for preparing the composite quaternary ammonium salt disinfectant provided by the invention is the method for preparing a disinfectant stock solution, which, during use in practice, can be used only by diluting to a specified concentration in proportion. Therefore, the quaternary ammonium salt disinfectant prepared by diluting the stock solution should also fall within the scope of the invention.
In order to make the object, technical solutions and advantages of the invention clearer, the technical solutions in the embodiments of the invention will be described clearly and completely, obviously, the described embodiments are some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work are within the scope of the present invention. In addition, in order to better explain the present invention, a lot of specific details are given in the following embodiments. It will be understood by those skilled in the art that the present invention may be practiced without certain specific details. In some embodiments, materials, elements, methods, means, etc., well known to those skilled in the art, are not described in detail so as to highlight the spirit of the present invention.
Throughout the specification and claims, the term “comprising” or variations thereof, such as “including” or “containing” and the like, will be understood to include the stated elements or components and not to exclude other elements or other components, unless expressly indicated otherwise.
In the following examples, all the raw materials used are common commercially available raw materials, as shown in Table 1:
Didecyl dimethyl ammonium chloride (2.86 g), dodecyl dimethyl benzyl ammonium chloride (4.0 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (4.0 g), Kathon (0.5 g), AEO9 (4.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.8 g), and ethanol (1.0 g) were dissolved in purified water (80.44 g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (2.86 g), dodecyl dimethyl benzyl ammonium chloride (4.0 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (4.0 g), Kathon (0.1g), AEO9 (4.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.8 g), and ethanol (1.0 g) were dissolved in purified water (80.84g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (2.86 g), dodecyl dimethyl benzyl ammonium chloride (4.0 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (4.0 g), Kathon (0.5 g), urotropine (2.5 g), AEO9 (4.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.8 g), and octanediol (2.0 g) were dissolved in purified water (76.94g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (2.86 g), C12-C16 alkyl dimethyl benzyl ammonium chloride (4.0 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (4.0 g), MIT (0.25 g), urotropine (1.25 g), AEO9 (4.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.4 g), EDTA (0.4 g), octanediol (1.0 g), and ethanol (1.0 g) were dissolved in purified water (78.44 g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (1.43 g), dioctyl dimethyl ammonium chloride (1.43 g), dodecyl dimethyl benzyl ammonium chloride (4.0 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (4.0 g), MIT (0.5 g), AEO9 (4.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.8 g), and ethanol (1.0 g) were dissolved in purified water (80.44 g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (1.28 g), octyl decyl dimethyl ammonium chloride (2.56 g), dioctyl dimethyl ammonium chloride (1.28 g), C12-C16 alkyl dimethyl benzyl ammonium chloride (2.4 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (2.4 g), MIT (0.5 g), AEO9 (4.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.8 g), and dipropylene glycol (1.0 g) were dissolved in purified water (81.38 g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (1.28 g), octyl decyl dimethyl ammonium chloride (2.56 g), dioctyl dimethyl ammonium chloride (1.28 g), dodecyl dimethyl benzyl ammonium chloride (2.4 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (2.4 g), Kathon (0.5 g), AEO9 (4.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.8 g), octanediol (2.0 g), and ethanol (10.0 g) were dissolved in purified water (70.38 g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (2.86 g), dodecyl dimethyl benzyl ammonium chloride (4.0 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (4.0 g), o-phthalaldehyde (1.25 g), MIT (0.25 g), poloxamer 188 (2.0 g), AEO9 (2.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.8 g), dipropylene glycol (4.0 g), and octanediol (2.0 g) were dissolved in purified water (74.44 g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (0.72 g), octyl decyl dimethyl ammonium chloride (1.44g), dioctyl dimethyl ammonium chloride (0.72 g), C12-C16 alkyl dimethyl benzyl ammonium chloride (4.0 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (4.0 g), BIT (0.5 g), urotropine (0.5 g), AEO9 (4.0 g), dipotassium hydrogen phosphate (2.0 g), potassium dihydrogen phosphate (1.2 g), and ethylene glycol (5.0 g) were dissolved in purified water (75.92 g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (1.43 g), C12-C16 alkyl dimethyl benzyl ammonium chloride (6.0 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (6.0 g), OIT (0.5 g), AEO9 (2.0 g), poloxamer 188 (2.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.8 g), 1,2-octanediol (1.0 g), and ethylene glycol (4.0 g) were dissolved in purified water (73.87 g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (2.86 g), dodecyl dimethyl benzyl ammonium chloride (4.0 g), C12-C14 alkyl dimethyl ethyl benzyl ammonium chloride (4.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.8 g), and ethanol (1.0 g) were dissolved in purified water (84.94g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Didecyl dimethyl ammonium chloride (2.86 g), dodecyl dimethyl benzyl ammonium chloride (8.0 g), Kathon (0.5 g), AEO9 (4.0 g), EDTA-4Na (2.4 g), EDTA-2Na (0.8 g), and ethanol (1.0 g) were dissolved in purified water (80.44 g) with stirring, to prepare a stock solution of composite quaternary ammonium salt disinfectant, which was diluted by 40 times for use in various tests in the application.
Commercially available Dr. Xiao's compound double long-chain quaternary ammonium salt disinfectant is used, which consists of didecyl dimethyl ammonium chloride and octyl decyl dimethyl ammonium chloride, having the content of active ingredients of 1.7-2.0 g/L.
Test 1: Test for Physico-chemical indicators
The physico-chemical indicators of the samples of Examples 1-10 were tested respectively by using the samples of Comparative Example 1-3 as the controls. The test items and test methods are shown in Table 2.
The results are shown in Table 3.
Test 2: Test for killing microorganisms
A test for the effect on air disinfection was conducted using the sample of Example 1 as a testing disinfectant according to the method of 2.1.3 in Technical Standard for Disinfection (2002 edition), and the test results are shown in Table 4.
Staphylococcus aureus and
Escherichia coli at 5 × 105 CFU/m3
Test 3: Test for inactivating novel coronavirus (2019-nCoV)
This test was commissioned to Analytical and Testing Center of Capital Regions Co., Ltd. to carry out a test for inactivating novel coronavirus (2019-nCoV) using the composite quaternary ammonium salt disinfectant provided by the inventive embodiment according to the method of 2.1.1.10.7 in Technical Standard for Disinfection (2002 edition), and the data are shown in Table 5.
Test 4 : Test for killing enveloped virus
This test was commissioned to College of Life Science and Technology, Beijing University of Chemical Technology, to carry out the test for inactivating coronavirus (GX-P2V), which was a novel coronavirus isolated from pangolins, and had 92.2% homology with the spike protein of novel coronavirus (2019-nCoV) and 90% identity in term of the amino acid sequence, thus being suitable as a substitution model for screening anti-novel coronavirus drugs (see Lam, T.T., Jia, N., Zhang, Y. et al. Identifying SARS-CoV-2-related coronaviruses in Malayan Pangolin S. Nature (2020) for the virus and properties thereof. haps ://doi. org/10.1038/s41586 -020-2169 -0). The inactivation test was conducted using the sample of Example 1 as a testing disinfectant and a coronavirus (GX-P2V) as a testing virus strain according to the method of 2.1.1.10.7 in Technical Standard for Disinfection (2002 edition), and the test results are shown in Table 6.
Test 5: Test for inactivating non-enveloped virus
The inactivation test was conducted using the sample of Example 1 as a testing disinfectant and poliovirus as a testing virus strain according to the method of 2.1.1.10.7 in Technical Standard for Disinfection (2002 edition), and the test results are shown in Table 7.
Test 7 Test for inactivating non-enveloped viruses
Test 6: Organic interference test
The test was conducted by using the samples of Example 1 and Comparative Examples 1 and 2 as disinfectants, according to the method of 2.1.10.2.3 in Technical Standard for Disinfection (2002 edition), in which 0, 25% and 50% calf serum were added, respectively, as organic interferents, and Pseudomonas aeruginosa was used as a testing strain, to study the effect of organics on the sample disinfection, and the results are shown in Table 8.
Test 8 Organic interference test
Under the organic interference, the composite quaternary ammonium salt disinfectants provided by Example 1 and Example 9 of the invention can tolerate the interference of 25% and 50% calf serum, and kill the test strains in a short time, while those provided by the Comparative examples 1 and 2 can not tolerate the interference of 50% calf serum. The composite quaternary ammonium salt disinfectant provided by the example of the invention can be applied more conveniently and has a more extensive application field as compared with Comparative examples 1 and 2.
Test 7: Hard water interference test
The test was conducted according to the method of 2.1.1.2 in Technical Standard for Disinfection (2002 edition), using diluents of the disinfectant stock solutions provided by Example 1, Example 8, Comparative Example 1 and Comparative Example 2 of the application as testing disinfectants, respectively, and Pseudomonas aeruginosa as a testing strain, wherein each of the disinfectant stock solution was diluted by 40 times with common tap water, followed by standing for 72 hours, to obtain the diluent, as shown in Table 9.
Test 8: Test for the speed of killing microorganisms
The tests for killing microorganisms were conducted using the samples of Example 1-10 as testing disinfectants, respectively, and the samples of Comparative Example 1-3 as controls, as well as Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans as test strains. All the above tests were carried out according to the method of 2.1.1.2 in Technical Standard for Disinfection (2002 edition), and the test results are shown in Table 10.
Staphylococcus aureus
Pseudomonas aeruginosa
It can be seen from the table above that, when the action time was shortened from 5 min to 0.5 min, the composite quaternary ammonium salt disinfectants obtained in the inventive examples achieved the same bactericidal effect, as compared with the disinfectants obtained in the Comparative examples.
Test 9: Toxicological indicators
A test for toxicological indicators was conducted using the sample of Example 1 as a testing disinfectant according to the method of 2.3.1, 2.3.2, 2.3.3, 2.3.4 and 2.3.8 in Technical Standard for Disinfection (2002 edition), and the test results are shown in Table 11.
Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present invention and not to limit it; although the present invention has been described in detail with reference to the foregoing examples, it will be understood by one of ordinary skill in the art that the technical solutions described in the foregoing examples can still be modified or some technical features can be equivalently substituted; however, these modifications or substitutions do not make the essence of the corresponding technical solutions depart from the spirit and scope of the technical solutions of various examples of the present invention.
The composite quaternary ammonium salt disinfectant provided by the invention has a synergistic effect among its components, which greatly improves the capacity of resisting interferences by hard water and organics; and can kill not only bacterial propagules, lipophilic viruses (enveloped viruses, such as novel coronavirus) and fungi, but also hydrophilic viruses (non-enveloped viruses). In addition, the composite quaternary ammonium salt disinfectant provided by the invention has the following advantages: having a rapid speed of kill, easy to use, non-toxic, non-irritative, and non-corrosive, and can be used for disinfecting various surfaces, air, hands, skin, mucous membranes, etc., as well as water bodies, aquaculture industries and other fields, which is suitable for large-scale promotion and shows a good market prospect.
| Number | Date | Country | Kind |
|---|---|---|---|
| 202011538060.0 | Dec 2020 | CN | national |
| Number | Date | Country | |
|---|---|---|---|
| Parent | PCT/CN2021/140734 | Dec 2021 | US |
| Child | 18051858 | US |
