Claims
- 1. A multilayer ion-sensitive electrode device for sensing electrolytes in biological fluids, said device having a membrane deposited on a base, the membrane comprising a polymeric matrix having an ionophore and a sufficient amount of a fluorophore dispersed therein,
- said fluorophore being selected from the class of 7-amino-coumarin derivatives having structure shown below: ##STR4## where R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are hydrogen, alkyl or alkylene groups, and R.sub.5, and R.sub.6 are hydrogen, alkyl, alkylene, haloalkyl, aryl, halo, carboxyalkyl, oxo-alkyl, or cyano,
- said sufficient amount of the fluorophore adjusted so that the membrane is optically distinguished from the base under ambient lighting when a radiation pattern illuminates the ion-sensitive electrode device.
- 2. A device according to claim 1 wherein said fluorophore is coumarin 6 or coumarin 314.
- 3. A device according to claim 1 wherein the ionophore is sensitive to an ion chosen from the group consisting of chloride ions, potassium ions, lithium ions, calcium ions, magnesium ions, carbonate ions, hydrogen ions, and sodium ions.
- 4. A device according to claim 1 wherein said polymeric matrix is selected from the group consisting of polyvinylchloride, copolymers of polyvinylchloride, polyurethanes, methacrylate polymers, acrylic polymers, and polymers compatible with polyvinylchloride, and mixtures thereof.
- 5. A device according to claim 1, wherein said base comprises a planar substrate having a plurality of conductive elements disposed thereon, at least one dielectric layer having a plurality of openings therethrough, each opening being in communication with no more than one of said conductive elements, the membrane being portioned and disposed within said openings so that communication is established between said membrane portions and said conductive elements.
- 6. The multilayer ion-sensitive electrode device of claim 1 wherein the amount of coumarin derivative is within the range between 0.001% and 2% by weight.
- 7. The multilayer ion-sensitive electrode device of claim 1 wherein a machine vision system is used to optically distinguish between the membrane and the base.
- 8. A multilayer ion-sensitive electrode device for sensing electrolytes in biological fluids, the device having at least two membrane layers deposited on a base, each of said layers comprising a polymeric matrix having an ionophore and a sufficient amount of a fluorophore dispersed therein,
- said fluorophore being selected from the class of 7-amino-coumarin derivatives having structure shown below: ##STR5## where R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are hydrogen, alkyl or alkylene groups, and R.sub.5, and R.sub.6 are hydrogen, alkyl, alkylene, haloalkyl, aryl, halo, carboxyalkyl, oxo-alkyl, or cyano,
- said sufficient amount of the fluorophore adjusted so that the membrane layers are optically distinguished from the base under ambient lighting when a radiation pattern illuminates the ion-sensitive electrode device.
- 9. A multilayer ion-sensitive electrode device for sensing electrolytes in biological fluids, said device having at least two membrane layers applied successively in a lower and upper relationship on a base, the lower of said layers comprising a polymeric matrix having an ionophore and a sufficient amount of a fluorophore dispersed therein,
- said fluorophore being selected from the class of 7-amino-coumarin derivatives having structure shown below: ##STR6## where R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are hydrogen, alkyl or alkylene groups, and R.sub.5, and R.sub.6 are hydrogen, alkyl, alkylene, haloalkyl, aryl, halo, carboxyalkyl, oxo-alkyl, or cyano,
- said sufficient amount of the fluorophore adjusted so that the membrane layers are optically distinguished from the base under ambient lighting when a radiation pattern illuminates the ion-sensitive electrode device,
- the upper of said layers having dispersed therein at least one radiation absorbing agent.
Parent Case Info
This is a continuation of application Ser. No. 08/668,223, filed on Jun. 21, 1996, now abandoned.
US Referenced Citations (9)
Foreign Referenced Citations (4)
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Date |
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0 319 873 A2 |
Jun 1989 |
EPX |
0 654 664 A2 |
May 1995 |
EPX |
WO 8700286 |
Jan 1987 |
WOX |
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Non-Patent Literature Citations (2)
Entry |
Responses of Site-Controlled, Plasticized Membrane Electrodes, Linder et al., Analytical Chemistry, vol. 60, No. 4, pp. 295-301, Feb. 15, 1988. |
Ion-Selective Electrodes, Foreman et al., Automatic Chemical Analysis, Ellis Horwood Ltd., Chichester, England, 1975, pp. 74-81. |
Continuations (1)
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Number |
Date |
Country |
Parent |
668223 |
Jun 1996 |
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