Claims
- 1. A solid pharmaceutical, composition of active vitamins D.sub.3 having improved stability comprising:
- (a) an outer layer comprising an active vitamin D.sub.3 and an excipient which is readily soluble in an organic solvent and containing from 500 to 100,000 parts by weight of said excipient per 1 weight part of active vitamin D.sub.3, said excipient which is readily soluble in an organic solvent being selected from the group consisting of polyvinyl pyrrolidone, methyl cellulose, ethyl cellulose hydroxypropyl cellulose, hydroxypropylmethyl celluose, and mixtures thereof and
- (b) a core material comprising an excipient which is slightly soluble in an organic solvent, said excipient which is slightly soluble in an organic solvent being selected from the group consisting of crystalline cellulose, lactose, and mixtures thereof; said core material containing from 1 to 100 parts by weight of said excipient which is slightly soluble in an organic solvent per 1 weight part of said excipient in the outer layer which is readily soluble in an organic solvent.
- 2. A solid pharmaceutical composition of active vitamins D.sub.3 having improved stability according to claim 1, wherein said active vitamin D.sub.3 is at least one of 1.alpha.-hydroxy vitamin D.sub.3, 24- or 25-hydroxy vitamin D.sub.3, 24-oxo vitamin D.sub.3, or a vitamin D.sub.3 -26,23-lactone.
- 3. A solid pharmaceutical composition of active vitamins D.sub.3 having improved stability comprising:
- (a) an outer layer comprising an active vitamin D.sub.3 and an excipient which is readily soluble in an organic solvent and containing from 500 to 100,000 parts by weight of said excipient per 1 weight part of active vitamin D.sub.3, said excipient which is readily soluble in an organic solvent being selected from the group consisting of polyvinyl pyrrolidone, methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, and mixtures thereof and
- (b) a core material comprising an excipient which is slightly soluble in an organic solvent, said excipient which is slightly soluble in an organic solvent being selected from the group consisting of crystalline cellulose, lactose, and mixtures thereof; said core material containing from 1 to 10,000 parts by weight of said excipient which is slightly soluble in an organic solvent per 1 weight part of said excipient in the outer layer which is readily soluble in an organic solvent.
- 4. A solid pharmaceutical composition of active vitamins D.sub.3 having improved stability according to claim 3, wherein said active vitamin D.sub.3 is at least one of 1.alpha.-hydroxy vitamin D.sub.3, 24- or 25-hydroxy vitamin D.sub.3, 24-oxo vitamin D.sub.3, or vitamin D.sub.3 -26,23-lactone.
Priority Claims (1)
Number |
Date |
Country |
Kind |
58-26898 |
Feb 1983 |
JPX |
|
Parent Case Info
This is a continuation of application Ser. No. 554,669 filed Nov. 23, 1983, now abandoned.
US Referenced Citations (5)
Foreign Referenced Citations (1)
Number |
Date |
Country |
1081667 |
Jun 1982 |
GBX |
Continuations (1)
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Number |
Date |
Country |
Parent |
554669 |
Nov 1983 |
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