Claims
- 1. A composition that comprises:(i) azelaic acid as a therapeutically active ingredient in a concentration of 5 to 20% by weight, (iii) at least one triacylglyceride in a concentration of 0.5 to 5% by weight, (iv) propylene glycol, and (v) at least one polysorbate, in an aqueous phase that further comprises water and salts, and the composition further comprises (ii) at least one polyacrylic acid, and (vi) lecithin, wherein the composition is in the form of a hydrogel.
- 2. A composition according to claim 1, wherein the composition is in a form for topical administration.
- 3. A composition according to claim 1, wherein the lecithin is soybean lecithin.
- 4. A composition according to claim 1, wherein the lecithin is present at a concentration within the range of greater than 0% to 1% by weight.
- 5. A composition according to claim 1, wherein the individual components, independently of one another, have the following concentrations;(ii) at least one polyacrylic acid at a concentration of 0.5 to 2% by weight, (iii) at least one triacylglyceride at a concentration of 0.5 to 5% by weight, (iv) propylene glycol at a concentration of 5 to 15% by weight, and (v) at least one polysorbate at a concentration of 0.5 to 3% by weight.
- 6. A composition according to claim 1, wherein the individual components, independently of one another, have the following concentrations:(ii) at least one polyacrylic acid at a concentration of 1±0.25% by weight, (iii) at least one triacylglyceride at a concentration of 2±1% by weight, (iv) propylene glycol at a concentration of 10±2-% by weight, and (v) at least one polysorbate at a concentration of 2±0.5% by weight.
- 7. A composition according to claim 1, wherein the composition further comprises at least one physiologically compatible, pharmacological adjuvant or vehicle.
- 8. A method for treating rosacea, presbyderma, melasma, acne and/or skin irritations in a patient, comprising administering to the patient in need thereof a therapeutically effective amount of the composition according to claim 1.
- 9. The method of claim 8, wherein the composition is administered topically.
- 10. A composition according to claim 1, wherein the azelaic acid is present at a concentration of 10 to 18% by weight.
- 11. A composition according to claim 1, wherein the lecithin is present at a concentration within the range of greater than 0% to 3% by weight.
- 12. A composition according to claim 1, further comprising benzoic acid.
Priority Claims (2)
Number |
Date |
Country |
Kind |
197 53 044 |
Nov 1997 |
DE |
|
198 08 086 |
Feb 1998 |
DE |
|
Parent Case Info
This application is a 371 of PCT/EP98/07370, filed Nov. 18, 1998, which claims benefit of 60/074,850, filed Feb. 12, 1998.
The invention relates to a composition with azelaic acid in a hydrogel. In addition, the use of azelaic acid-hydrogel as a pharmaceutical agent is part of the invention. This application claims the German priorities DE 197 53 044 with the application date of Nov. 19, 1997 and DE 198 08 086 with the application date of Feb. 20, 1998. The US filing of U.S. Ser. No. 60/074,850 with the filing date of Feb. 12, 1998 is claimed as an additional priority for the USA.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/EP98/07370 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO99/25332 |
5/27/1999 |
WO |
A |
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5362494 |
Zysman et al. |
Nov 1994 |
A |
5618522 |
Kaleta et al. |
Apr 1997 |
A |
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Number |
Date |
Country |
336880 |
Mar 1989 |
EP |
696452 |
Feb 1996 |
EP |
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Feb 1995 |
WO |
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WO |
WO 9511700 |
May 1995 |
WO |
96 05806 |
Feb 1996 |
WO |
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Dec 1996 |
WO |
Non-Patent Literature Citations (1)
Entry |
Grant & Hackh's Chemical Dictionary, 1987, McGraw-Hlll, Inc., Fifth edition, p. 291. |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/074850 |
Feb 1998 |
US |