Claims
- 1. A peptide YY (PYY) composition comprised of a solubilizing agent, a chelating agent, a polyol and a PYY peptide wherein the PYY peptide is comprised of an amino acid sequence selected from the group consisting of SEQ ID NOs: 2, 3 and SEQ ID NOs: 90-105.
- 2. The PYY composition of claim 1 wherein the PYY composition is comprised of at least two polyols.
- 3. The PYY composition of claim 2 wherein the polyols are selected from the group consisting of sucrose, mannitol, sorbitol, lactose, L-arabinose, D-erythrose, D-ribose, D-xylose, D-mannose, trehalose, D-galactose, lactulose, cellobiose, gentibiose, glycerin and polyethylene glycol.
- 4. The PYY composition of claim 3 wherein the polyols are lactose and sorbitol.
- 5. The PYY compostion of claim 1 wherein the chelating agent is ethylene diamine tetraacetic acid (EDTA) or ethylene glycol tetraacetic acid (EGTA).
- 6. The PYY composition of claim 5 wherein the chelating agent is ethylenediamine tetraacetic acid (EDTA).
- 7. The PYY composition of claim 1 wherein the solubilizing agent is selected from the group consisting of a cyclodextran, hydroxypropyl-p-cyclodextran, sulfobutylether-β-cyclodextran and methyl-p-cyclodextrin.
- 8. The PYY composition of claim 7 wherein the solubilizing agent is a cyclodextrin.
- 9. The PYY composition of claims 1 wherein the composition is further comprised of a surface-active agent.
- 10. The PYY composition of claim 9 wherein the surface-active agent is selected from the group consisting of nonionic polyoxyethylene ether, bile salts such, sodium glycocholate (SGC), deoxycholate (DOC), derivatives of fusidic acid, sodium taurodihydrofusidate (STDHF), L-α-phospharidycholine didecanoyl (DDPC) polysorbate 80 and polysorbate 20,), polyethylene glycol (PEG), cetyl alcohol, polyvinylpyrolidone (PVP), polyvinyl alcohol (PVA), lanolin alcohol, and sorbitan monooleate.
- 11. The PYY composition of claim 10 wherein the surface-active agent is L-α-Phospharidycholine didecanoyl (DDPC).
- 12. The PYY composition of claim 1 wherein the composition is an aqueous PYY composition further comprised of water.
- 13. The PYY composition of claim 12 wherein the aqueous PYY composition has a pH of about of about 3-6.
- 14. The PYY composition of claim 13 wherein the pH of the aqueous PYY composition is 5.0±0.3.
- 15. The PYY composition of claim 1 wherein the PYY peptide is comprised of PYY(3-36) (SEQ ID NO: 2).
- 16. A PYY composition comprised of a solubilizing agent, a chelating agent, a polyol, a surface active agent and a PYY peptide wherein the PYY peptide is comprised of an amino acid sequence selected from the group consisting of SEQ ID NOs: 2, 3 and SEQ ID NOs: 90-105.
- 17. The PYY composition of claim 16 wherein the composition is further comprised of at least two polyols.
- 18. The PYY composition of claim 17 wherein the polyols are selected from the group consisting of sucrose, mannitol, sorbitol, lactose, L-arabinose, D-erythrose, D-ribose, D-xylose, D-mannose, trehalose, D-galactose, lactulose, cellobiose, gentibiose, glycerin and polyethylene glycol.
- 19. The PYY composition of claim 18 wherein the polyols are lactose and sorbitol.
- 20. The PYY composition of claim 16 wherein the chelating agent is ethylene diamine tetraacetic acid (EDTA) or ethylene glycol tetraacetic acid (EGTA).
- 21. The PYY composition of claim 20 wherein the chelating agent is ethylenediamine tetraacetic acid (EDTA).
- 22. The PYY composition of claim 16 wherein the solubilizing agent is selected from the group consisting of a cyclodextran, hydroxypropyl-β-cyclodextran, sulfobutylether-β-cyclodextran and methyl-β-cyclodextrin.
- 23. The PYY composition of claim 22 wherein the solubilizing agent is a methyl-β-cyclodextrin.
- 24. The PYY composition of claim 16 wherein the surface-active agent is selected from the group consisting of nonionic polyoxyethylene ether, bile salts such, sodium glycocholate (SGC), deoxycholate (DOC), derivatives of fusidic acid, sodium taurodihydrofusidate (STDHF), L-α-phospharidycholine didecanoyl (DDPC) polysorbate 80 and polysorbate 20,), polyethylene glycol (PEG), cetyl alcohol, polyvinylpyrolidone (PVP), polyvinyl alcohol (PVA), lanolin alcohol, and sorbitan monooleate.
- 25. The PYY composition of claim 24 wherein the surface-active agent is L-α-phospharidycholine didecanoyl (DDPC).
- 26. The PYY composition of claim 16 wherein the composition is an aqueous PYY composition further comprised of water.
- 27. The PYY composition of claim 26 wherein the aqueous PYY composition has a pH of about of about 3-6.
- 28. The PYY composition of claim 27 wherein the pH of the aqueous PYY composition is 5.0+0.3.
- 29. The PYY composition of claim 16 wherein the PYY peptide is comprised of PYY(3-36) (SEQ ID NO: 2).
- 30. A PYY composition comprised of methyl-β-cyclodextrin, EDTA, lactose, sorbitol, DDPC and a PYY peptide wherein the PYY peptide is comprised of an amino acid sequence selected from the group consisting of SEQ ID NOs: 2, 3 and SEQ ID NOs: 90-105.
- 31. The PYY composition of claim 30 wherein the PYY peptide is comprised of PYY(3-36) (SEQ ID NO: 2).
- 32. A PYY composition comprised of water, sodium citrate, citric acid, methyl-β-cyclodextrin, EDTA, lactose, sorbitol, DDPC and PYY(3-36) (SEQ ID NO: 2), wherin the formulation has a pH of about 5.0+0.3.
- 33. The PYY composition of claim 32 further comprised of a preservative selected from the group consisting of chlorobutanol and benzalkonium chloride.
- 34. The composition of claim 33 wherein the preservative is chlorobutanol.
- 35. A PYY composition comprised of water, chlorobutanol, sodium citrate, citric acid, methyl-β-cyclodextrin, EDTA, lactose, sorbitol, DDPC and PYY(3-36) (SEQ ID NO: 2), wherein the formulation has a pH of about 5.0±0.3.
- 36. A PYY composition comprised of water, benzalkonium chloride, sodium citrate, citric acid, methyl-β-cyclodextrin, EDTA, lactose, sorbitol, DDPC and PYY(3-36) (SEQ ID NO: 2), wherein the formulation has a pH of about 5.0±0.3.
- 37. A PYY composition comprised of water, chlorobutanol at a concentration of 5 mg/ml, sodium citrate at a concentration of 1.62 mg/ml, citric acid at a concentration of 0.86 mg/ml, methyl-β-cyclodextrin at a concentration of 45 mg/ml, EDTA at a concentration of 1 mg/ml, lactose at a concentration of 9 mg/ml, sorbitol at a concentration of 18.2 mg/ml, DDPC at a concentration of 1 mg/ml and PYY(3-36) (SEQ ID NO: 2) at a concentration of 1 mg/ml, wherein the formulation has a pH of about 5.0±0.3.
- 38. A PYY composition comprised of water, chlorobutanol at a concentration of 5 mg/ml, sodium citrate at a concentration of 1.62 mg/ml, citric acid at a concentration of 0.86 mg/ml, methyl-β-cyclodextrin at a concentration of 45 mg/ml, EDTA at a concentration of 1 mg/ml, lactose at a concentration of 9 mg/ml, sorbitol at a concentration of 18.2 mg/ml, DDPC at a concentration of 1 mg/ml and PYY(3-36) (SEQ ID NO: 2) at a concentration of 15 mg/ml, wherein the formulation has a pH of about 5.0±0.3.
Priority Claims (1)
Number |
Date |
Country |
Kind |
PCT/US03/40538 |
Dec 2003 |
WO |
|
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This is a continuation application and claims priority under 35 U.S.C. §120 of co-pending U.S. patent application Ser. No. 10/745,069 filed Dec. 23, 2003, which is a continuation-in-part of U.S. patent application Ser. No. 10/322,266, filed Dec. 17, 2002, and claims priority under 35 U.S.C. §119 (e) of U.S. Provisional Application No. 60/493,226, filed Aug. 7, 2003, U.S. Provisional Application No. 60/501,170, filed Sep. 8, 2003, U.S. Provisional Application No. 60/510,785, filed Oct. 10, 2003, U.S. Provisional Application No. 60/517,290, filed Nov. 4, 2003; U.S. Provisional Application No. 60/518,812, filed on Nov. 10, 2003; and PCT/US03/40538, filed on Dec. 17, 2003; the entire contents of these applications are incorporated herein by reference.
Provisional Applications (5)
|
Number |
Date |
Country |
|
60493226 |
Aug 2003 |
US |
|
60501170 |
Sep 2003 |
US |
|
60510785 |
Oct 2003 |
US |
|
60517290 |
Nov 2003 |
US |
|
60518812 |
Nov 2003 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
10745069 |
Dec 2003 |
US |
Child |
10768288 |
Jan 2004 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
10322266 |
Dec 2002 |
US |
Child |
10745069 |
Dec 2003 |
US |