Claims
- 1. A method for inducing CD81 dependent antiproliferation in a human or veterinary patient, said method comprising the step of:
(A) administering to the patient a therapeutically effective amount of an amantadine analogue having the formula: 16wherein, X is Boron or Carbon; A is NH and NHR1, where R1 is H, alkyl or imino-alkyl amino; Z is a acyclic or cyclic, saturated or unsaturated, chiral or achiral, straight or branched hydrocarbyl group with from 1 to 10 carbon atoms, C═O, SO2, or absent; and R is an acyclic or cyclic, saturated or unsaturated, chiral or achiral, straight or branched hydrocarbyl group with from 1 to 20 carbon atoms and —CH—R2R3 —CHR2R3, wherein R2 is selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, (CH2)n-Q, where n is 1-4 and Q is BSH, —OH, —NH2, —NH—CO—NH2, —NH—C═(NR4) NHR5, —COOH and its alkyl esters, and —CONH2 and R4 and R5 are H, C1-4 alkyl or R4 and R5 may combine to form a cyclic ring, R2 and A may combine to form a cyclic ring; R3 is carboxyl, its alkyl esters, carboxamide or substituted carboxamide, sulfonic acid, sulfonate esters, sulfonamide, substituted sulfonamide, phosphonic and phosphoric acids and their alkyl esters.
- 2. A method according to No. 1 wherein the method is carried out to prevent or treat Hepatitis C.
- 3. A composition of matter having the formula:
A method for inducing CD81 dependent antiproliferation in a human or veterinary patient, said method comprising the step of: (A) administering to the patient a therapeutically effective amount of an amantadine analogue having the formula: 17wherein, X is Boron or Carbon; A is NH and NHR1, where R1 is H, alkyl or imino-alkyl amino; Z is a acyclic or cyclic, saturated or unsaturated, chiral or achiral, straight or branched hydrocarbyl group with from 1 to 10 carbon atoms, C═O, SO2, or absent; and R is an acyclic or cyclic, saturated or unsaturated, chiral or achiral, straight or branched hydrocarbyl group with from 1 to 20 carbon atoms and —CH—R2R3, wherein R2 is selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, (CH2)n—Q, where n is 1-4 and Q is BSH, —OH, —NH2, —NH—CO—NH2, —NH—C═(NR4) NHR5, —COOH and its alkyl esters, and —CONH2 and R4 and R5 are H, C1 -4 alkyl or R4 and R5 may combine to form a cyclic ring, R2 and A may combine to form a cyclic ring; R3 is carboxyl, its alkyl esters, carboxamide or substituted carboxamide, sulfonic acid, sulfonate esters, sulfonamide, substituted sulfonamide, phosphonic and phosphoric acids and their alkyl esters.
RELATED APPLICATION
[0001] This patent application claims priority to U.S. Provisional patent Application No.60/457,854 entitled “Compositions and Methods for Inducing CD81 Dependent Antiproliferation and for Treating Hepatitis C and Other Disorders” filed on Mar. 25, 2003, the entirety of which is expressly incorporated herein by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60457854 |
Mar 2003 |
US |