Claims
- 1. A composition comprising citicoline, or a pharmaceutically-acceptable salt thereof, wherein said citicoline is metabolized to form at least one of cytidine, uridine, and choline.
- 2. The composition of claim 1, further comprising one or more of the compounds selected from the group consisting of linoleic acid and linolenic acid or their active metabolites.
- 3. The composition of claim 2, wherein the active metabolite is arachidonic acid or docsohexenoic acid.
- 4. A composition comprising at least one of choline or a pharmaceutically-acceptable salt thereof, cytidine or a pharmaceutically-acceptable salt thereof; and uridine or a pharmaceutically-acceptable salt thereof.
- 5. The composition of claim 4, further comprising a fatty acid.
- 6. The composition of claim 4, wherein the fatty acid is selected from the group consisting of linoleic acid and linolenic acid or their active metabolites.
- 7. A method for preparing a composition for use in treating or preventing memory impairment or cognitive dysfunction, comprising the steps of:
providing an effective amount of citicoline, or a pharmaceutically-acceptable salt thereof; providing an effective amount of one or more second compounds selected from the group consisting of linoleic acid and linolenic acid; and combining said citicoline with said one or more second compounds to form a pharmaceutically-acceptable preparation.
- 8. A method for preparing a composition for use in treating or preventing memory impairment or cognitive dysfunction, comprising the steps of:
providing an effective amount of choline or a pharmaceutically-acceptable salt thereof; providing an effective amount of cytidine or a pharmaceutically-acceptable salt thereof; and providing an effective amount of uridine or a pharmaceutically-acceptable salt thereof.
- 9. A method of preventing or treating cognitive disorders or memory impairment, comprising the steps of:
administering an effective amount of choline or a pharmaceutically-acceptable salt thereof; administering an effective amount of cytidine or a pharmaceutically-acceptable salt thereof; administering an effective amount of uridine or a pharmaceutically-acceptable salt thereof; and continuing said administration for a period of at least about six weeks.
- 10. The method of claim 9, further comprising the step of administering one or more of the compounds selected from the group consisting of linoleic acid and linolenic acid.
- 11. A method of preventing or treating cognitive disorders or memory impairment, comprising the steps of:
administering an effective amount of choline or a pharmaceutically-acceptable salt thereof; administering an effective amount of cytidine or a pharmaceutically-acceptable salt thereof; and continuing said administration for a period of at least about six weeks.
- 12. The method of claim 11, further comprising the step of administering one or more of the compounds selected from the group consisting of linoleic acid and linolenic acid.
- 13. A method of preventing or treating cognitive disorders or memory impairment, comprising the steps of:
administering an effective amount of choline or a pharmaceutically-acceptable salt thereof; administering an effective amount of uridine or a pharmaceutically-acceptable salt thereof; and continuing said administration for a period of at least about six weeks.
- 14. The method of claim 13, further comprising the step of administering one or more of the compounds selected from the group consisting of linoleic acid and linolenic acid.
- 15. A method of preventing or treating cognitive disorders or memory impairment, comprising the steps of:
administering an effective amount of cytidine or a pharmaceutically-acceptable salt thereof; administering an effective amount of uridine or a pharmaceutically-acceptable salt thereof; and continuing said administration for a period of at least about six weeks.
- 16. The method of claim 15, further comprising the step of administering one or more of the compounds selected from the group consisting of linoleic acid and linolenic acid.
- 17. A method of preventing or treating cognitive disorders or memory impairment, comprising the steps of:
administering an effective amount of citicoline, or a pharmaceutically-acceptable salt thereof, combined with one or more of the compounds selected from the group consisting of linoleic acid and linolenic acid; and continuing to administer said citicoline for a period of at least about six weeks.
Parent Case Info
[0001] This application claims priority from U.S. Serial No. 60/339,445, filed Dec. 14, 2001.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60339445 |
Dec 2001 |
US |