Gros et al., “Regulated production of mature insulin by non-βcells,” Human Gene Therapy 8:2249-2259 (1997). |
Vollenweider et al., “Processing of proinsulin by Furin, PC2, and PC3 in (Co) transfected COS (Monkey Kidney) cells,” Diabetes 44:1075-1080 (1995). |
Ali et al., Preventing Gastroepiploic Artery Spasm: Papaverine vs Calcium Channel Blockade, J. Surgical Research, 74:41-45 (1997). |
Becker et al., Use of Recombinant Adenovirus for Metabolic Engineering of Mammalian Cells, Methods in Cell Biol., 43:161-189 (1994). |
Dale et al., A Randomized Controlled Phase III Trial of Recombinant Human Granulocyte Colony-Stimulating Factor (Filgrastim) for Treatment of Severe Chronic Neutropenia, Blood, 81(10) :2496-2502 (1993). |
Dale et al., Cyclic Neutropenia: A Clinical Review, Blood Reviews, 2:178-185 (1988). |
Daniels et al., Glucose Regulation of Transforming Gowth Factor-α Expression is Mediated by Products of the Hexosamine Biosynthesis Pathway, Mol. Endocrinol., 7(8) :1041-1048 (1993). |
Shimon Efrat, Genetic engineering of β-cells for cell therapy of diabetes: cell growth, function, and immunogenicity, Diabetes Reviews, 4(2):224-234 (1996). |
Geary et al., Gene Transfer in Baboons Using Prosthetic Vascular Grafts Seeded with Retrovirally Transduced Smooth Muscle Cells: A Model for Local and Systemic Gene Therapy, Hum. Gene Ther., 5: 1211-1216 (1994). |
Gros et al., Regulated Production of Mature Insulin by Non-β-Cells, Human Gene Therapy, 8: 2249-2259 (1997). |
Groskreutz et al., Genetically Engineered Proinsulin Constitutively Processed and Secreted as Mature, Active Insulin, J. Biol. Chem., 269(8):6241-6245 (1994). |
Hock et al., Expression of Human Adenosine Deaminase From Various Strong Promoters After Gene Transfer Into Human Hematopoietic Cell Lines, Blood, 74(2):876-881 (1989). |
Hosaka et al., Arg-X-Lys/Arg-Arg Motif as a Signal for Precursor Cleavage Catalyzed by Furin within the Constitutive Secretory Pathway, J. Biol. Chem., 266(19):12127-12130 (1991). |
Kawakami et al., Subcutaneous Xenotransplantation of Hybrid Artificial Pancreas Encapsulating Pancreatic B Cell Line (MIN6): Functional and Histological Study, Cell Transplant, 6(5):541-545 (1997). |
Kolodka et al., Gene therapy for diabetes mellitus in rats by hepatic expression of insulin, Proc. Natl. Acad. Sci. USA, 92 : 3293-3297 (1995). |
Lejnieks et al., Granulocyte Colony Stimulating Factor Expression from Transduced Vascular Smooth Muscle Cells Provides Sustained Neutrophil Increases in Rats, Hum. Gene Ther., 7:1431-1436 (1996). |
McClain et al., Hexosamines and Insulin Resistance, Diabetes, 45:1003-1009 (1996). |
McClain et al., Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells, Proc. Natl. Acad. Sci. USA, 89: 8150-8154 (1992). |
McKnight et al., Molecular Cloning, cDNA Sequence, and Bacterial Expression of Human Glutamine:Fructose-6-phosphate Amidotransferase, J.Biol.Chem., 267(35) :25208-25212 (1992). |
Christopher B. Newgard, Cellular Engineering and Gene Therapy Strategies for Insulin Replacement in Diabetes, Diabetes, 43:341-350 (1994). |
Odagiri et al., Function of the Human Insulin Promoter in Primary Cultured Islet Cells, J. Biol. Chem., 271(4):1909-1915 (1996). |
Osborne et al., Design of vectors for efficient expression of human purine nucleoside phosphorylase in skin fibroblasts from enzyme-deficient humans, Proc. Natl. Acad. Sci. USA, 85 :6851-6855 (1988). |
Osborne et al., Transduced vascular smooth muscle cells in a canine model of gene therapy, Clinical Res. 41(2):194A (1993). |
Osborne et al., Gene therapy for long-term expression of erythropoietin in rats, Proc. Natl. Acad. Sci. USA, 92:8055-8058 (1995). |
Osborne et al., Long Term Expression of Human of Human Adenosine Deaminase in Mice After Transplantation of Bone Marrow Infected with Amphotropic Retroviral Vectors, Hum. Gene Ther., 1:31-41 (1990). |
Raja et al., Transcriptional Regulation of the Human Transforming Growth Factor-α Gene, Mol. Endocrinol., 5(4):514-520 (1991). |
Ramesh et al., High-titer bicistronic retroviral vectors employing foot-and-mouth disease virus internal ribosome entry site, Nucleic Acids Res., 24(14):2697-2700, (1996). |
Sayeski et al., The murine glutamine:fructose-6-phosphate amidotransferas-encoding cDNA sequence, Gene, 140:289-290 (1994). |
Scharp et al., Protection of Encapsulated Human Islets Implanted without Immunosuppression in Patients With Type I or Type II Diabetes and in Nondiabetic Control Subjects, Diabetes, 43:1167-1170 (1994). |
Schuppin et al., Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing βTC3 cells, Biochem. J., 313:259-268 (1996). |
Smeekens et al., Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3, Proc. Natl. Acad. Sci. USA, 89:8822-8826 (1992). |
Stockschlaeder et al., L-Histidinol Provides Effective Selection of Retrovirus-Vector-Transduced Keratinocytes Without Impairing Their Proliferative Potential, Hum. Gene Ther., 2:33-39 (1991). |
Sugiyama et al., Defective Adenoassociated Viral-Mediated Transfection of Insulin Gene by Direct Injection Into Liver Parenchyma Decreases Blood Glucose of Diabetic Mice, Horm. Metab. Res., 29:599-603 (1997). |
Wang et al., An encapsulation system for the immunoisolation of pancreatic islets, Nature Biotech., 15:358-362 (1997). |
Yanagita et al., Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non-endocrine cell line, COS-7, FEBS Letters, 311(1):55-59 (1992). |
Zhou et al., In vitro and in vivo evaluation of insulin-producing βTC6-F7 cells in microcapsules, Am. J. Physiol., 274 (Cell Physiol. 43):C1356-C1362 (1998). |
Naffakh et al, “Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts,” Proc. Natl. Acad. Sci USA, 92:3194-3198 (1995). |
XP002131707 & JP08033472A (Terumo Corp.), Feb. 6, 1996 (Apr. 6, 1996) abstract. |
Smeekens et al. (PNAS, vol. 89, pp. 8822-8826, 1992).* |
Lu et al. (FEBS Letters, vol. 399: pp. 37-42, 1996).* |
Morgan et al. (Nucleic Acids Research, 1992, V.20(6), pp. 1293-1299).* |
Walther et al., J. Mol. Med., vol. 74, pp. 379-392, 1996.* |
Morgan et al. , 1992, Nucleic Acids Research, V.20(6),pp. 1293-1299. |