Claims
- 1. A method of prophylaxis against the development of epithelial carcinomas of the skin, gastrointestinal tract, respiratory tract or genito-urinary tract which comprises enterally administering to persons susceptible to such carcinomas a composition comprising a medicinally inert, pharmaceutically acceptable carrier material and 13-cis vitamin A acid or a pharmaceutically acceptable salt thereof, said composition being administered in an amount sufficient to provide from about 0.05 mg to about 3.0 mg of 13-cis vitamin A acid or its pharmaceutically acceptable salt per kg of body weight per day.
- 2. A method in accordance with claim 1 wherein said composition additionally contains an antioxidant selected from the group consisting of alpha-tocopherol, N-methyl-.gamma.-tocopherolamine, butylated hydroxyanisole, butylated hydroxytoluene, ethoxyquin and mixtures thereof.
- 3. The method in accordance with claim 1 wherein the daily amount of 13-cis vitamin A acid administered is from 0.1 mg. to about 1.0 mg. per kilogram of body weight of said person.
- 4. A method in accordance with claim 1 wherein said composition is administered in the form of pharmaceutical unit dosage, each unit dosage containing from about 5.0 mg. to about 50.0 mg. of 13-cis vitamin A acid or its pharmaceutically acceptable salt.
- 5. A method in accordance with claim 1 wherein said pharmaceutically acceptable salt is the sodium salt.
- 6. A method in accordance with claim 1 wherein said carcinomas are those of the skin, bronchi, gastrointestinal tract, genitalia or oral cavity.
- 7. A method in accordance with claim 6 wherein said composition is administered in the form of pharmaceutical unit dosage, each unit dosage containing from about 5.0 mg. to about 50.0 mg. of 13-cis vitamin A acid or its pharmaceutically acceptable salt.
- 8. A method in accordance with claim 6 wherein said composition is administered to patients afflicted with a premalignant condition characterized by a propensity to mature into one of said carcinomas.
- 9. A method in accordance with claim 8 wherein said premalignant condition is bronchogenic disease.
- 10. A composition in unit dosage form for enteral administration comprising as an active ingredient 13-cis Vitamin A acid or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier suitable for enteral administration, said active ingredient being present in said composition in an amount of from about 5 mg to about 50 mg.
- 11. The composition of claim 10 wherein said carrier is vegetable oil.
- 12. The composition of claim 10 wherein said unit dosage form is a tablet, capsule or dragee.
- 13. The composition of claim 12 wherein said unit dosage form is a capsule.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9474/70 |
Jun 1970 |
CHX |
|
RELATED APPLICATIONS
This application is a continuation of application Ser. No. 161,200 filed June 19, 1980, which in turn is a continuation of Ser. No. 950,760 filed Oct. 12, 1978, now abandoned, which in turn is a continuation application of Ser. No. 820,280 filed July 29, 1977, now abandoned, which in turn is a continuation of Ser. No. 676,078 filed Apr. 12, 1976, now abandoned, which in turn is a continuation of Ser. No. 535,602 filed Dec. 23, 1974, now abandoned, which in turn is a continuation of Ser. No. 384,848 filed Aug. 2, 1973, now abandoned, which in turn is a continuation-in-part of U.S. patent application Ser. No. 49,976 filed June 25, 1970, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3252865 |
Klavi |
May 1966 |
|
Non-Patent Literature Citations (10)
Entry |
Prutkin, J. of Investigative Dermatology, vol. 49, No. 2, pp. 165-172, Aug. 1967. |
Chemical Abstracts, 59:7918d, (1963). |
Zile et al., Biophys. Acta, 141, (1967), pp. 639-641. |
Chemical Abstracts (I), 68:28185(S), 1968. |
Stuttgen, Dermatologica, 124:78-79, (1962). |
Oroshnik, J. Am. Chem. Soc., 74, pp. 295-304, (1952). |
Planta et al., Helv. Chim. Acta, vol. 45, pp. 548-561. |
DeMan et al., Netherland J. of Agricultural Science, vol. 6, pp. 237-244, (1958). |
DeMan et al., Nature, 201, pp. 77-78, (1964). |
Murray, Proc. Soc. Exp. Biol. Med., vol. 111, pp. 609-611, (1962). |
Continuations (6)
|
Number |
Date |
Country |
Parent |
161200 |
Jun 1980 |
|
Parent |
950760 |
Oct 1978 |
|
Parent |
820280 |
Jul 1977 |
|
Parent |
676078 |
Apr 1976 |
|
Parent |
535602 |
Dec 1974 |
|
Parent |
384848 |
Aug 1976 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
49976 |
Jun 1970 |
|