COMPOSITIONS AND METHODS OF MODULATING IMMUNE RESPONSE

Information

  • Patent Application
  • 20190216893
  • Publication Number
    20190216893
  • Date Filed
    June 02, 2017
    7 years ago
  • Date Published
    July 18, 2019
    5 years ago
Abstract
Disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response. Also disclosed, herein are methods, pharmaceutical compositions, and vaccines for inducing an immune response.
Description
SEQUENCE LISTING

The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 31, 2017, is named 48054-705_601_SL.txt and is 3,856,317 bytes in size.


BACKGROUND OF THE DISCLOSURE

The immune system is a complex network of responses and processes that protects an organism and enables the organism to fight against a foreign agent. In some instances, there are two types of immune response when presented with a foreign agent. In one instance, the immune system responds with a B cell-mediated response (e.g., humoral response or antibody-mediated response) when foreign agents (e.g., antigens and/or pathogens) are present in the lymph or blood. In another instance, the immune system responds with a T cell-mediated response (e.g., a cell-mediated response) when cells that display aberrant MHC markers are present. In some instances, both humoral response and cell-mediated response are triggered by a foreign agent when, e.g., both antigens and cells containing aberrant MHC markers are present.


SUMMARY OF THE DISCLOSURE

In certain embodiments, disclosed herein include methods, pharmaceutical compositions, and vaccines for modulating an immune response. In some embodiments, included herein are methods of administering a small molecule fragment described herein for modulating an immune response. In additional embodiments, described herein are pharmaceutical compositions and vaccines which comprise a small molecule fragment described herein for modulating an immune response.


Disclosed herein, in certain embodiments, is a method of modulating an immune response in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a small molecule fragment of Formula (I):




embedded image




    • wherein:

    • RM is a reactive moiety selected from a Michael acceptor moiety, a leaving group moiety, or a moiety capable of forming a covalent bond with the thiol group of a cysteine residue; and

    • F is a small molecule fragment moiety.





In some embodiments, the small molecule fragment interacts with an endogenous cysteine-containing polypeptide expressed in the subject to form a cysteine-containing polypeptide-small molecule fragment adduct. In some embodiments, the small molecule fragment is covalently bound to a cysteine residue of the cysteine-containing polypeptide. In some embodiments, the cysteine-containing polypeptide-small molecule fragment adduct induces an immune response. In some embodiments, the cysteine-containing polypeptide-small molecule fragment adduct induces a humoral immune response. In some embodiments, the cysteine-containing polypeptide-small molecule fragment adduct induces a cell-mediated immune response. In some embodiments, the cysteine-containing polypeptide-small molecule fragment adduct increases an immune response relative to a control. In some embodiments, the cysteine-containing polypeptide-small molecule fragment adduct increases a humoral immune response relative to a control. In some embodiments, the cysteine-containing polypeptide-small molecule fragment adduct increases a cell-mediated immune response relative to a control. In some embodiments, the control is the level of an immune response in the subject prior to administration of the small molecule fragment. In some embodiments, the control is the level of an immune response in a subject who has not been exposed to the small molecule fragment. In some embodiments, the control is the level of a humoral immune response or a cell-mediated immune response in the subject prior to administration of the small molecule fragment. In some embodiments, the control is the level of a humoral immune response or a cell-mediated immune response in a subject who has not been exposed to the small molecule fragment. In some embodiments, the cysteine-containing polypeptide is overexpressed in a disease or condition. In some embodiments, the cysteine-containing polypeptide comprises one or more mutations. In some embodiments, the cysteine-containing polypeptide comprising one or more mutations is overexpressed in a disease or condition. In some embodiments, the disease or condition is cancer. In some embodiments, the cysteine-containing polypeptide is a cancer-associated protein. In some embodiments, the cysteine-containing polypeptide is overexpressed in a cancer. In some embodiments, the cysteine-containing polypeptide comprising one or more mutations is overexpressed in a cancer. In some embodiments, the cysteine-containing polypeptide is a non-denatured form of the polypeptide. In some embodiments, the cysteine-containing polypeptide comprises a biologically active cysteine site. In some embodiments, the biologically active cysteine site is a cysteine residue that is located about 10 Å or less to an active-site ligand or residue. In some embodiments, the cysteine residue that is located about 10 Å or less to the active-site ligand or residue is an active site cysteine. In some embodiments, the biologically active cysteine site is an active site cysteine. In some embodiments, the biologically active cysteine site is a cysteine residue that is located greater than 10 Å from an active-site ligand or residue. In some embodiments, the cysteine residue that is located greater than 10 Å from the active-site ligand or residue is a non-active site cysteine. In some embodiments, the biologically active cysteine site is a non-active site cysteine. In some embodiments, the cysteine-containing polypeptide is an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, a plasma protein, transcription related protein, translation related protein, mitochondrial protein, or cytoskeleton related protein. In some embodiments, the cysteine-containing polypeptide is an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, transcription related protein, or translation related protein. In some embodiments, the enzyme comprises kinases, proteases, or deubiquitinating enzymes. In some embodiments, the protease is a cysteine protease. In some embodiments, the cysteine protease comprises caspases. In some embodiments, the signaling protein comprises vascular endothelial growth factor. In some embodiments, the signaling protein comprises a redox signaling protein. In some embodiments, the cysteine-containing polypeptide is about 20, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100 amino acid residues in length or more. In some embodiments, the cysteine-containing polypeptide comprises a protein illustrated in Tables 1-5. In some embodiments, the Michael acceptor moiety comprises an alkene or an alkyne moiety. In some embodiments, the covalent bond is formed between a portion of the Michael acceptor moiety on the small molecule fragment and a portion of a cysteine residue of the cysteine-containing polypeptide. In some embodiments, F is obtained from a compound library. In some embodiments, the compound library comprises ChemBridge fragment library, Pyramid Platform Fragment-Based Drug Discovery, Maybridge fragment library, FRGx from AnalytiCon, TCI-Frag from AnCoreX, Bio Building Blocks from ASINEX, BioFocus 3D from Charles River, Fragments of Life (FOL) from Emerald Bio, Enamine Fragment Library, IOTA Diverse 1500, BIONET fragments library, Life Chemicals Fragments Collection, OTAVA fragment library, Prestwick fragment library, Selcia fragment library, TimTec fragment-based library, Allium from Vitas-M Laboratory, or Zenobia fragment library. In some embodiments, F is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B). In some embodiments, F further comprises a linker moiety that connects F to the carbonyl moiety. In some embodiments, the small molecule fragment is a small molecule fragment illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B). In some embodiments, the small molecule fragment has a molecular weight of about 150 Dalton or higher. In some embodiments, the small molecular fragment has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of the small molecular fragment is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, the small molecular fragment of Formula (I) has a molecular weight of about 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the method further comprises administering a cysteine-containing polypeptide-small molecule fragment adduct. In some embodiments, the cysteine-containing polypeptide is at most 50 amino acid residues in length. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the method further comprises administration of an adjuvant. In some embodiments, the small molecule fragment is formulated for parenteral, oral, or intranasal administration. In some embodiments, the subject is a human.


Disclosed herein, in certain embodiments, is a vaccine comprising a small molecule fragment of Formula (I):




embedded image




    • wherein:

    • RM is a reactive moiety selected from a Michael acceptor moiety, a leaving group moiety, or a moiety capable of forming a covalent bond with the thiol group of a cysteine residue; and

    • F is a small molecule fragment moiety.





In some embodiments, the small molecule fragment interacts with a cysteine-containing polypeptide to form a cysteine-containing polypeptide-small molecule fragment adduct. In some embodiments, the small molecule fragment is covalently bond to a cysteine residue of the cysteine-containing polypeptide. In some embodiments, the cysteine-containing polypeptide is an endogenous cysteine-containing polypeptide expressed in a subject. In some embodiments, administration of the small molecule fragment induces an immune response. In some embodiments, administration of the small molecule fragment induces a humoral immune response. In some embodiments, administration of the small molecule fragment induces a cell-mediated immune response. In some embodiments, administration of the small molecule fragment increases an immune response relative to a control. In some embodiments, administration of the small molecule fragment increases a humoral immune response relative to a control. In some embodiments, administration of the small molecule fragment increases a cell-mediated immune response relative to a control. In some embodiments, the control is the level of an immune response in the subject prior to administration of the small molecule fragment. In some embodiments, the control is the level of an immune response in a subject who has not been exposed to the small molecule fragment. In some embodiments, the control is the level of a humoral immune response or a cell-mediated immune response in the subject prior to administration of the small molecule fragment. In some embodiments, the control is the level of a humoral immune response or a cell-mediated immune response in a subject who has not been exposed to the small molecule fragment. In some embodiments, the cysteine-containing polypeptide is overexpressed in a disease or condition. In some embodiments, the cysteine-containing polypeptide comprises one or more mutations. In some embodiments, the cysteine-containing polypeptide comprising one or more mutations is overexpressed in a disease or condition. In some embodiments, the disease or condition is cancer. In some embodiments, the cysteine-containing polypeptide is a cancer-associated protein. In some embodiments, the cysteine-containing polypeptide is overexpressed in a cancer. In some embodiments, the cysteine-containing polypeptide comprising one or more mutations is overexpressed in a cancer. In some embodiments, the cysteine-containing polypeptide is a non-denatured form of the polypeptide. In some embodiments, the cysteine-containing polypeptide is an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, a plasma protein, transcription related protein, translation related protein, mitochondrial protein, or cytoskeleton related protein. In some embodiments, the cysteine-containing polypeptide comprises a protein illustrated in Tables 1-5. In some embodiments, the Michael acceptor moiety comprises an alkene or an alkyne moiety. In some embodiments, the covalent bond is formed between a portion of the Michael acceptor moiety on the small molecule fragment and a portion of a cysteine residue of the cysteine-containing polypeptide. In some embodiments, F is obtained from a compound library. In some embodiments, the compound library comprises ChemBridge fragment library, Pyramid Platform Fragment-Based Drug Discovery, Maybridge fragment library, FRGx from AnalytiCon, TCI-Frag from AnCoreX, Bio Building Blocks from ASINEX, BioFocus 3D from Charles River, Fragments of Life (FOL) from Emerald Bio, Enamine Fragment Library, IOTA Diverse 1500, BIONET fragments library, Life Chemicals Fragments Collection, OTAVA fragment library, Prestwick fragment library, Selcia fragment library, TimTec fragment-based library, Allium from Vitas-M Laboratory, or Zenobia fragment library. In some embodiments, F is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B). In some embodiments, F further comprises a linker moiety that connects F to the carbonyl moiety. In some embodiments, the small molecule fragment is a small molecule fragment illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B). In some embodiments, the small molecule fragment has a molecular weight of about 150 Dalton or higher. In some embodiments, the small molecular fragment has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of the small molecular fragment is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, the small molecular fragment of Formula (I) has a molecular weight of about 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the vaccine further comprises a cysteine-containing polypeptide-small molecule fragment adduct. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the vaccine further comprises an adjuvant. In some embodiments, the vaccine is formulated for parenteral, oral, or intranasal administration.


Disclosed herein, in certain embodiments, is a pharmaceutical composition comprising:

    • a) a cysteine-containing polypeptide covalently bond to a small molecule fragment, wherein the small molecule fragment is a small molecule fragment of Formula (I):




embedded image






      • wherein:

      • RM is a reactive moiety selected from a Michael acceptor moiety, a leaving group moiety, or a moiety capable of forming a covalent bond with the thiol group of a cysteine residue; and

      • F is a small molecule fragment moiety; and wherein the small molecule fragment is covalently bond to a cysteine residue of the cysteine-containing polypeptide; and



    • b) an excipient.





In some embodiments, the cysteine-containing polypeptide is a non-denatured form of the polypeptide. In some embodiments, the cysteine-containing polypeptide comprises a biologically active cysteine site. In some embodiments, the biologically active cysteine site is a cysteine residue that is located about 10 Å or less to an active-site ligand or residue. In some embodiments, the cysteine residue that is located about 10 Å or less to the active-site ligand or residue is an active site cysteine. In some embodiments, the biologically active cysteine site is an active site cysteine. In some embodiments, the biologically active cysteine site is a cysteine residue that is located greater than 10 Å from an active-site ligand or residue. In some embodiments, the cysteine residue that is located greater than 10 Å from the active-site ligand or residue is a non-active site cysteine. In some embodiments, the biologically active cysteine site is a non-active site cysteine. In some embodiments, the cysteine-containing polypeptide is an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, a plasma protein, transcription related protein, translation related protein, mitochondrial protein, or cytoskeleton related protein. In some embodiments, the cysteine-containing polypeptide is an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, transcription related protein, or translation related protein. In some embodiments, the enzyme comprises kinases, proteases, or deubiquitinating enzymes. In some embodiments, the protease is a cysteine protease. In some embodiments, the cysteine protease comprises caspases. In some embodiments, the signaling protein comprises vascular endothelial growth factor. In some embodiments, the signaling protein comprises a redox signaling protein. In some embodiments, the cysteine-containing polypeptide is about 20, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100 amino acid residues in length or more. In some embodiments, the cysteine-containing polypeptide comprises a protein illustrated in Tables 1-5. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified protein. In some embodiments, the isolated and purified protein is a protein illustrated in Tables 1-5. In some embodiments, the cysteine-containing polypeptide is at most 50 amino acid residues in length. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 80% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 85% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 90% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 95% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 96% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 97% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 98% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 99% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising 100% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the cysteine-containing polypeptide comprises an isolated and purified polypeptide consisting of 100% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the Michael acceptor moiety comprises an alkene or an alkyne moiety. In some embodiments, the covalent bond is formed between a portion of the Michael acceptor moiety on the small molecule fragment and a portion of a cysteine residue of the cysteine-containing polypeptide. In some embodiments, F is obtained from a compound library. In some embodiments, the compound library comprises ChemBridge fragment library, Pyramid Platform Fragment-Based Drug Discovery, Maybridge fragment library, FRGx from AnalytiCon, TCI-Frag from AnCoreX, Bio Building Blocks from ASINEX, BioFocus 3D from Charles River, Fragments of Life (FOL) from Emerald Bio, Enamine Fragment Library, IOTA Diverse 1500, BIONET fragments library, Life Chemicals Fragments Collection, OTAVA fragment library, Prestwick fragment library, Selcia fragment library, TimTec fragment-based library, Allium from Vitas-M Laboratory, or Zenobia fragment library. In some embodiments, F is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B). In some embodiments, F further comprises a linker moiety that connects F to the carbonyl moiety. In some embodiments, the small molecule fragment is a small molecule fragment illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B). In some embodiments, the small molecule fragment has a molecular weight of about 150 Dalton or higher. In some embodiments, the small molecular fragment has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of the small molecular fragment is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, the small molecular fragment of Formula (I) has a molecular weight of about 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the pharmaceutical composition is formulated for parenteral, oral, or intranasal administration.


Disclosed herein, in certain embodiments, is a vaccine comprising a pharmaceutical composition disclosed above. In some embodiments, the vaccine further comprises an adjuvant. In some embodiments, the vaccine is formulated for parenteral, oral, or intranasal administration.


Disclosed herein, in certain embodiments, is an isolated and purified antibody or its binding fragment thereof comprising a heavy chain CDR1, CDR2 and CDR3 sequence and a light chain CDR1, CDR2, and CDR3 sequence, wherein the heavy chain and light chain CDRs interact with a cysteine-containing polypeptide that is covalently bond to a small molecule fragment, wherein the small molecule fragment is a small molecule fragment of Formula (I):




embedded image


wherein:

    • RM is a reactive moiety selected from a Michael acceptor moiety, a leaving group moiety, or a moiety capable of forming a covalent bond with the thiol group of a cysteine residue; and
    • wherein the small molecule fragment is covalently bond to a cysteine residue of the cysteine-containing polypeptide.


In some embodiments, the antibody or its binding fragment thereof comprises a humanized antibody or binding fragment thereof, chimeric antibody or binding fragment thereof, monoclonal antibody or binding fragment thereof, monovalent Fab′, divalent Fab2, single-chain variable fragment (scFv), diabody, minibody, nanobody, single-domain antibody (sdAb), camelid antibody, or binding fragment thereof.


Disclosed herein, in certain embodiments, is a kit comprising a pharmaceutical composition described above.


Disclosed herein, in certain embodiments, is a kit comprising an isolated and purified antibody or its binding fragment thereof disclosed above.





BRIEF DESCRIPTION OF THE DRAWINGS

Various aspects of the disclosure are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the disclosure are utilized, and the accompanying drawings of which:



FIG. 1A-FIG. 1B illustrate exemplary small molecule fragments described herein.





DETAILED DESCRIPTION OF THE DISCLOSURE

Cysteine containing proteins encompass a large repertoire of proteins that participate in numerous cellular functions such as mitogenesis, proliferation, apoptosis, gene regulation, and proteolysis. These proteins include enzymes, transporters, receptors, channel proteins, adaptor proteins, chaperones, signaling proteins, plasma proteins, transcription related proteins, translation related proteins, mitochondrial proteins, or cytoskeleton related proteins. Dysregulated expression of a cysteine containing protein, in many cases, is associated with or modulates a disease, for example, such as cancer.


In some instances, small molecule compounds are capable of eliciting an immune response. In some instances, these small molecule compounds are referred to as haptens. In some cases, a hapten is a non-immunogenic compound but becomes immunogenic when it interacts with a carrier molecule such as a protein. For example, upon administration of a small molecule hapten, the hapten forms an adduct with a protein of interest in a process refers to as haptenization. In some cases, the protein-hapten adduct becomes antigenically active and enables priming of T cells and B cells, thereby directing immune response to a cell that expresses the protein of interest.


In some embodiments, disclosed herein are small molecule fragments that elicit an immune response upon interaction with cysteine-containing proteins (or cysteine-containing polypeptides). In some instances, also disclosed herein includes use of a small molecule fragment described herein to elicit or modulate an immune response in a subject. In such instances, the small molecule fragment forms an adduct with an endogenous cysteine-containing protein, and subsequently directs immune response to the cell that expresses the endogenous cysteine-containing protein. In some instances, the cell that expresses the endogenous cysteine-containing protein is a disease cell (e.g., a cancerous cell). In some instances, the endogenous cysteine-containing protein is present only in a diseased cell (e.g., a cancerous cell). In other instances, the endogenous cysteine-containing protein is overexpressed in a diseased cell (e.g., a cancerous cell) and/or comprises one or more mutations in a diseased cell (e.g., a cancerous cell).


In some embodiments, also disclosed herein are vaccines and pharmaceutical compositions that comprise one or more small molecule fragments described herein. In some instances, additionally descried herein are vaccines and pharmaceutical compositions that comprise one or more cysteine-containing polypeptide-small molecule fragment adducts or antibodies that recognize a cysteine-containing polypeptide-small molecule fragment adduct described herein.


In additional embodiments, described herein include kits for use with any of the methods, vaccines, and pharmaceutical compositions disclosed herein.


Small Molecule Fragments

In some embodiments, described herein include pharmaceutical compositions, vaccines, and methods of use of a small molecule fragment. In some embodiments, a small molecule fragment described herein comprises a non-naturally occurring molecule. In some instances, the non-naturally occurring molecule does not include a natural and/or non-natural peptide fragment, or a small molecule that is produced naturally within the body of a mammal.


In some embodiments, a small molecule fragment described herein comprises a molecular weight of about 100 Dalton or higher. In some embodiments, a small molecule fragment comprises a molecular weight of about 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some instances, the molecular weight of a small molecule fragment is between about 150 and about 500, about 150 and about 450, abut 150 and about 440, about 150 and about 430, about 150 and about 400, about 150 and about 350, about 150 and about 300, about 150 and about 250, about 170 and about 500, about 180 and about 450, about 190 and about 400, about 200 and about 350, about 130 and about 300, or about 120 and about 250 Dalton.


In some embodiments, the molecular weight of a small molecule fragment described herein is the molecular weight prior to enrichment with one or more elements selected from a halogen, a nonmetal, a transition metal, or a combination thereof. In some embodiments, the molecular weight of a small molecule fragment described herein is the molecular weight prior to enrichment with a halogen. In some embodiments, the molecular weight of a small molecule fragment described herein is the molecular weight prior to enrichment with a nonmetal. In some embodiments, the molecular weight of a small molecule fragment described herein is the molecular weight prior to enrichment with a transition metal.


In some embodiments, a small molecule fragment described herein comprises micromolar or millimolar binding affinity. In some instances, a small molecule fragment comprises a binding affinity of about 1 μM, 10 μM, 100 μM, 500 μM, 1 mM, 10 mM, or higher.


In some embodiments, a small molecule fragment described herein has a high ligand efficiency (LE). Ligand efficiency is the measurement of the binding energy per atom of a ligand to its binding partner. In some instances, the ligand efficiency is defined as the ratio of the Gibbs free energy (ΔG) to the number of non-hydrogen atoms of the compound (N):





LE=(ΔG)/N.


In some cases, LE is also arranged as:





LE=1.4(−log IC50)/N.


In some instances, the LE score is about 0.3 kcal mol−1 HA−1, about 0.35 kcal mol−1 HA−1, about 0.4 kcal mol−1 HA−1, or higher.


In some embodiments, a small molecule fragment described herein is designed based on the Rule of 3. In some embodiments, the Rule of 3 comprises a non-polar solvent-polar solvent (e.g. octanol-water) partition coefficient log P of about 3 or less, a molecular mass of about 300 Daltons or less, about 3 hydrogen bond donors or less, about 3 hydrogen bond acceptors or less, and about 3 rotatable bonds or less.


In some embodiments, a small molecule fragment described herein comprises three cyclic rings or less.


In some embodiments, a small molecule fragment described herein binds to a cysteine residue of a polypeptide that is about 20 amino acid residues in length or more. In some instances, a small molecule fragment described herein binds to a cysteine residue of a polypeptide that is about 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100 amino acid residues in length or more.


In some embodiments, a small molecule fragment described herein further comprises pharmacokinetic parameters that are unsuitable as a therapeutic agent for administration without further optimization of the small molecule fragments. In some instances, the pharmacokinetic parameters that are suitable as a therapeutic agent comprise parameters in accordance with FDA guideline, or in accordance with a guideline from an equivalent Food and Drug Administration outside of the United States. In some instances, the pharmacokinetic parameters comprise the peak plasma concentration (Cmax), the lowest concentration of a therapeutic agent (Cmin), volume of distribution, time to reach Cmax, elimination half-life, clearance, and the life. In some embodiments, the pharmacokinetic parameters of the small molecule fragments are outside of the parameters set by the FDA guideline, or by an equivalent Food and Drug Administration outside of the United States. In some instances, a skilled artisan understands, in view of the pharmacokinetic parameters of the small molecule fragments described herein, that these small molecule fragments are unsuited as therapeutic agents without further optimization.


In some embodiments, a small molecule fragment described herein comprises a reactive moiety which forms a covalent interaction with the thiol group of a cysteine residue of a cysteine-containing protein, and an affinity handle moiety.


In some instances, a small molecule fragment described herein is a small molecule fragment of Formula (I):




embedded image




    • wherein:

    • RM is a reactive moiety selected from a Michael acceptor moiety, a leaving group moiety, or a moiety capable of forming a covalent bond with the thiol group of a cysteine residue; and F is a small molecule fragment moiety.





In some instances, the Michael acceptor moiety comprises an alkene or an alkyne moiety. In some cases, F is obtained from a compound library. In some cases, the compound library comprises ChemBridge fragment library, Pyramid Platform Fragment-Based Drug Discovery, Maybridge fragment library, FRGx from AnalytiCon, TCI-Frag from AnCoreX, Bio Building Blocks from ASINEX, BioFocus 3D from Charles River, Fragments of Life (FOL) from Emerald Bio, Enamine Fragment Library, IOTA Diverse 1500, BIONET fragments library, Life Chemicals Fragments Collection, OTAVA fragment library, Prestwick fragment library, Selcia fragment library, TimTec fragment-based library, Allium from Vitas-M Laboratory, or Zenobia fragment library.


In some embodiments, a small molecule fragment of Formula (I) selectively interact with one or more protein variants. In some instances for example, a small molecule fragment of Formula (I) interacts or binds to the wild-type protein but does not bind to a mutant form of the protein. Conversely, in some instances, a small molecule fragment of Formula (I) interacts or binds to one specific protein mutant but does not interact with either the wild-type or the same protein comprising a different mutation. As used herein, the term “variant” comprises mutations within the protein sequence, additions or deletions of the protein sequence, and/or termini truncations. As used herein, the term “variant” comprises a protein having different conformations, for example, an active conformation or an inactive conformation. In some instances, a small molecule fragment of Formula (I) interacts with about 1, 2, 3, 4, 5, or more different variants of a protein of interest. In additional instances, a small molecule fragment of Formula (I) interacts with about 1 variant of a protein of interest. In additional instances, a small molecule fragment of Formula (I) interacts with about 2 variants of a protein of interest. In additional instances, a small molecule fragment of Formula (I) interacts with about 3 variants of a protein of interest. In additional instances, a small molecule fragment of Formula (I) interacts with about 4 variants of a protein of interest. In additional instances, a small molecule fragment of Formula (I) interacts with about 5 variants of a protein of interest.


In some embodiments, a small molecule fragment of Formula (I) does not contain a second binding site. In some instances, a small molecule fragment moiety does not bind to the protein. In some cases, a small molecule fragment moiety does not covalently bind to the protein. In some instances, a small molecule fragment moiety does not interact with a secondary binding site on the protein. In some instances, the secondary binding site is an active site such as an ATP binding site. In some cases, the active site is at least about 10, 15, 20, 25, 35, 40 Å, or more away from the biologically active cysteine residue. In some instances, the small molecule fragment moiety does not interact with an active site such as an ATP binding site.


In some instances, F is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B). In some instances, F is a small molecule fragment moiety illustrated in FIG. 1A. In some cases, F further comprises a linker moiety that connects F to the carbonyl moiety. In some cases, the small molecule fragment is a small molecule fragment illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some instances, F is a small molecule fragment moiety selected from: N-(4-bromophenyl)-N-phenylacrylamide, N-(1-benzoylpiperidin-4-yl)-2-chloro-N-phenylacetamide, 1-(4-benzylpiperidin-1-yl)-2-chloroethan-1-one, N-(2-(1H-indol-3-yl)ethyl)-2-chloroacetamide, N-(3,5-bis(trifluoromethyl)phenyl)acrylamide, N-(4-phenoxy-3-(trifluoromethyl)phenyl)-N-(pyridin-3-ylmethyl)acrylamide, N-(3,5-bis(trifluoromethyl)phenyl)acetamide, 2-chloro-1-(4-(hydroxydiphenylmethyl)piperidin-1-yl)ethan-1-one, (E)-3-(3,5-bis(trifluoromethyl)phenyl)-2-cyanoacrylamide, N-(3,5-bis(trifluoromethyl)phenyl)-2-bromopropanamide, N-(3,5-bis(trifluoromethyl)phenyl)-2-chloropropanamide, N-(3,5-bis(trifluoromethyl)phenyl)-N-(pyridin-3-ylmethyl)acrylamide, 3-(2-chloroacetamido)-5-(trifluoromethyl)benzoic acid, I-(4-(5-fluorobenzisoxazol-3-yl)piperidin-1-yl)prop-2-en-1-one, tert-butyl 4-(4-acrylamido-2,6-difluorophenyl)piperazine-1-carboxylate, N-(4-bromo-2,5-dimethylphenyl)acrylamide, 2-chloroacetamido-2-deoxy-α/β-D-glucopyranose, 2-chloro-1-(2-methyl-3,4-dihydroquinolin-1 (2H)-yl)ethan-1-one, N-cyclohexyl-N-phenylacrylamide, 1-(5-bromoindolin-1-yl)prop-2-en-1-one, N-(1-benzylpiperidin-4-yl)-N-phenylacrylamide, 2-chloro-N-(2-methyl-5-(trifluoromethyl)phenyl)acetamide, 1-(5-bromoindolin-1-yl)-2-chloroethan-1-one, 2-chloro-N-(quinolin-5-yl)acetamide, 1-(4-benzylpiperidin-1-yl)prop-2-en-1-one, 2-chloro-N-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methyl)acetamide, or 1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)prop-2-en-1-one.


In some embodiments, the small molecule fragment of Formula (I) comprise a molecular weight of about 100, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some instances, the molecular weight of the small molecule fragment of Formula (I) is between about 150 and about 500, about 150 and about 450, abut 150 and about 440, about 150 and about 430, about 150 and about 400, about 150 and about 350, about 150 and about 300, about 150 and about 250, about 170 and about 500, about 180 and about 450, about 190 and about 400, about 200 and about 350, about 130 and about 300, or about 120 and about 250 Dalton.


In some embodiments, the molecular weight of the small molecule fragment of Formula (I) is the molecular weight prior to enrichment with one or more elements selected from a halogen, a nonmetal, a transition metal, or a combination thereof. In some embodiments, the molecular weight of the small molecule fragment of Formula (I) is the molecular weight prior to enrichment with a halogen. In some embodiments, the molecular weight of the small molecule fragment of Formula (I) is the molecular weight prior to enrichment with a nonmetal. In some embodiments, the molecular weight of the small molecule fragment of Formula (I) is the molecular weight prior to enrichment with a transition metal.


In some instances, the small molecule fragment of Formula (I) comprises micromolar or millimolar binding affinity. In some instances, the small molecule fragment of Formula (I) comprises a binding affinity of about 1 μM, 10 μM, 10 μM, 500 μM, 1 mM, 10 mM, or higher.


In some cases, the small molecule fragment of Formula (I) has a LE score about 0.3 kcal mol−1 HA−1, about 0.35 kcal mol−1 HA−1, about 0.4 kcal mol−1 HA−1, or higher


In some embodiments, the small molecule fragment of Formula (I) follows the design parameters of Rule of 3. In some instances, the small molecule fragment of Formula (I) has a non-polar solvent-polar solvent (e.g. octanol-water) partition coefficient log P of about 3 or less, a molecular mass of about 300 Daltons or less, about 3 hydrogen bond donors or less, about 3 hydrogen bond acceptors or less, and about 3 rotatable bonds or less.


In some embodiments, the small molecule fragment of Formula (I) comprises three cyclic rings or less.


In some embodiments, the small molecule fragment of Formula (I) binds to a cysteine residue of a polypeptide (e.g., a cysteine-containing protein) that is about 20 amino acid residues in length or more. In some instances, the small molecule fragments described herein binds to a cysteine residue of a polypeptide (e.g., a cysteine-containing protein) that is about 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100 amino acid residues in length or more.


In some instances, the small molecule fragment of Formula (I) has pharmacokinetic parameters outside of the parameters set by the FDA guideline, or by an equivalent Food and Drug Administration outside of the United States. In some instances, a skilled artisan understands in view of the pharmacokinetic parameters of the small molecule fragment of Formula (I) described herein that these small molecule fragment is unsuited as a therapeutic agent without further optimization.


Cysteine-Containing Proteins

In some embodiments, disclosed herein include a cysteine-containing polypeptide. In some instances, the cysteine-containing polypeptide is about 20, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100 amino acid residues in length or more. In some instances, the cysteine-containing polypeptide is a cysteine-containing protein or its fragment thereof. In some instances, the cysteine-containing protein is a soluble protein or its fragment thereof, or a membrane protein or its fragment thereof. In some instances, the cysteine-containing protein is involved in one or more of a biological process such as protein transport, lipid metabolism, apoptosis, transcription, electron transport, mRNA processing, or host-virus interaction. In some instances, the cysteine-containing protein is associated with one or more of diseases such as cancer or one or more disorders or conditions such as immune, metabolic, developmental, reproductive, neurological, psychiatric, renal, cardiovascular, or hematological disorders or conditions.


In some embodiments, the cysteine-containing protein comprises a biologically active cysteine residue. In some embodiments, the cysteine-containing protein comprises one or more cysteines in which at least one cysteine is a biologically active cysteine residue. In some cases, the biologically active cysteine site is a cysteine residue that is located about 10 Å or less to an active-site ligand or residue. In some cases, the cysteine residue that is located about 10 Å or less to the active-site ligand or residue is an active site cysteine. In other cases, the biologically active cysteine site is a cysteine residue that is located greater than 10 Å from an active-site ligand or residue. In some instances, the cysteine residue is located greater than 12 Å, 15 Å, 20 Å, 25 Å, 30 Å, 35 Å, 40 Å, 45 Å, or greater than 50 Å from an active-site ligand or residue. In some cases, the cysteine residue that is located greater than 10 Å from the active-site ligand or residue is a non-active site cysteine. In additional cases, the cysteine-containing protein exists in an active form, or in a pro-active form.


In some embodiments, the cysteine-containing protein comprises one or more functions of an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, a plasma protein, transcription related protein, translation related protein, mitochondrial protein, or cytoskeleton related protein. In some embodiments, the cysteine-containing protein is an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, a plasma protein, transcription related protein, translation related protein, mitochondrial protein, or cytoskeleton related protein. In some instances, the cysteine-containing protein has an uncategorized function.


In some embodiments, the cysteine-containing protein is an enzyme. An enzyme is a protein molecule that accelerates or catalyzes chemical reaction. In some embodiments, non-limiting examples of enzymes include kinases, proteases, or deubiquitinating enzymes.


In some instances, exemplary kinases include tyrosine kinases such as the TEC family of kinases such as Tee, Bruton's tyrosine kinase (Btk), interleukin-2-inducible T-cell kinase (Itk) (or Emt/Tsk), Bmx, and Txk/Rlk; spleen tyrosine kinase (Syk) family such as SYK and Zeta-chain-associated protein kinase 70 (ZAP-70); Src kinases such as Src, Yes, Fyn, Fgr, Lck, Hck, Blk, Lyn, and Frk; JAK kinases such as Janus kinase 1 (JAK1), Janus kinase 2 (JAK2), Janus kinase 3 (JAK3), and Tyrosine kinase 2 (TYK2); or ErbB family of kinases such as Her1 (EGFR, ErbB1), Her2 (Neu, ErbB2), Her3 (ErbB3), and Her4 (ErbB4).


In some embodiments, the cysteine-containing protein is a protease. In some embodiments, the protease is a cysteine protease. In some cases, the cysteine protease is a caspase. In some instances, the caspase is an initiator (apical) caspase. In some instances, the caspase is an effector (executioner) caspase. Exemplary caspase includes CASP2, CASP8, CASP9, CASP10, CASP3, CASP6, CASP7, CASP4, and CASP5. In some instances, the cysteine protease is a cathepsin. Exemplary cathepsin includes Cathepsin B, Cathepsin C, CathepsinF, Cathepsin H, Cathepsin K, Cathepsin L1, Cathepsin L2, Cathepsin O, Cathepsin S, Cathepsin W, or Cathepsin Z.


In some embodiments, the cysteine-containing protein is a deubiquitinating enzyme (DUB). In some embodiments, exemplary deubiquitinating enzymes include cysteine proteases DUBs or metalloproteases. Exemplary cysteine protease DUBs include ubiquitin-specific protease (USP/UBP) such as USP1, USP2, USP3, USP4, USP5, USP6, USP7, USP8, USP9X, USP9Y, USP10, USP11, USP12, USP13, USP14, USP15, USP16, USP17, USP17L2, USP17L3, USP17L4, USP17L5, USP17L7, USP17L8, USP18, USP19, USP20, USP21, USP22, USP23, USP24, USP25, USP26, USP27X, USP28, USP29, USP30, USP31, USP32, USP33, USP34, USP35, USP36, USP37, USP38, USP39, USP40, USP41, USP42, USP43, USP44, USP45, or USP46; ovarian tumor (OTU) proteases such as OTUB1 and OTUB2; Machado-Josephin domain (MJD) proteases such as ATXN3 and ATXN3L; and ubiquitin C-terminal hydrolase (UCH) proteases such as BAP1, UCHL1, UCHL3, and UCHL5. Exemplary metalloproteases include the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases.


In some embodiments, exemplary cysteine-containing proteins as enzymes include, but are not limited to, Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Protein arginine N-methyltransferase 1 (PRMT1), Peptidyl-prolyl cis-trans isomerase NIMA-interaction (PIN1), Acetyl-CoA acetyltransferase (mitochondrial) (ACAT1), Glutathione S-transferase P (GSTP1), Elongation factor 2 (EEF2), Glutathione S-transferase omega-1 (GSTO1), Acetyl-CoA acetyltransferase (mitochondrial) (ACAT1), Protein disulfide-isomerase A4 (PDIA4), Prostaglandin E synthase 3 (PTGES3), Adenosine kinase (ADK), Elongation factor 2 (EEF2), Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1), Peroxiredoxin-5 (mitochondrial) (PRDX5), Inosine-5-monophosphate dehydrogenase 2 (IMPDH2), 3-hydroxyacyl-CoA dehydrogenase type-2 (HSDI7B10), Omega-amidase NIT2 (NIT2), Aldose reductase (AKR1B1), Monofunctional C1-tetrahydrofolate synthase (mitochondrial) (MTHFD1L), Protein disulfide-isomerase A6 (PDIA6), Pyruvate kinase isozymes M1/M2 (PKM), 6-phosphogluconolactonase (PGLS), Acetyl-CoA acetyltransferase (mitochondrial) (ACAT1), ERO1-like protein alpha (EROIL), Thioredoxin domain-containing protein 17 (TXNDC17), Protein disulfide-isomerase A4 (PDIA4), Protein disulfide-isomerase A3 (PDIA3), 3-ketoacyl-CoA thiolase (mitochondrial) (ACAA2), Dynamin-2 (DNM2), DNA replication licensing factor MCM3 (MCM3), Serine-tRNA ligase (cytoplasmic) (SARS), Fatty acid synthase (FASN), Acetyl-CoA acetyltransferase (mitochondrial) (ACAT1), Protein disulfide-isomerase (P4HB), Deoxycytidine kinase (DCK), Eukaryotic translation initiation factor 3 subunit (EIF3F), Protein disulfide-isomerase A6 (PDIA6), UDP-N-acetylglucosamine-peptide N-acetylglucosamine (OGT), Ketosamine-3-kinase (FN3KRP), Protein DJ-1 (PARK7), Phosphoglycolate phosphatase (PGP), DNA replication licensing factor MCM6 (MCM6), Fructose-2,6-bisphosphatase TIGAR (TIGAR), Cleavage and polyadenylation specificity factor subunit (CPSF3), Ubiquitin-conjugating enzyme E2 L3 (UBE2L3), Alanine-tRNA ligase, cytoplasmic (AARS), Mannose-1-phosphate guanyltransferase alpha (GMPPA), C-1-tetrahydrofolate synthase (cytoplasmic) (MTHFD1), Dynamin-1-like protein (DNM1L), Protein disulfide-isomerase A3 (PDIA3), Aspartyl aminopeptidase (DNPEP), Acetyl-CoA acetyltransferase (cytosolic) (ACAT2), Thioredoxin domain-containing protein 5 (TXNDC5), Thymidine kinase (cytosolic) (TK1), Inosine-5-monophosphate dehydrogenase 2 (IMPDH2), Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3), Integrin-linked protein kinase (ILK), Cyclin-dependent kinase 2 (CDK2), Histone acetyltransferase type B catalytic subunit (HAT1), Enoyl-CoA delta isomerase 2 (mitochondrial) (ECI2), C-1-tetrahydrofolate synthase (cytoplasmic) (MTHFD1), Deoxycytidine kinase (DCK), Ubiquitin-like modifier-activating enzyme 6 (UBA6), Protein-L-isoaspartate (D-aspartate)O-methyltransferase (PCMT1), Monofunctional C1-tetrahydrofolate synthase (mitochondrial) (MTHFD1L), Thymidylate kinase (DTYMK), Protein ETHEl (mitochondrial) (ETHEl), Arginine-tRNA ligase (cytoplasmic) (RARS), NEDD8-activating enzyme E1 catalytic subunit (UBA3), Dual specificity mitogen-activated protein kinase (MAP2K3), Ubiquitin-conjugating enzyme E2S (UBE2S), Amidophosphoribosyltransferase (PPAT), Succinate-semialdehyde dehydrogenase (mitochondrial) (ALDH5A1), CAD, Phosphoenolpyruvate carboxykinase (PCK2), 6-phosphofructokinase type C (PFKP), Acyl-CoA synthetase family member 2 (mitochondrial) (ACSF2), Multifunctional protein ADE2 (PAICS), Desumoylating isopeptidase 1 (DESI1), 6-phosphofructokinase type C (PFKIF), V-type proton ATPase catalytic subunit A (ATP6VIA), 3-ketoacyl-CoA thiolase (peroxisomal) (ACAA1), Galactokinase (GALK1), Thymidine kinase (cytosolic) (TK1), ATPase WRNIP1 (WRNIP1), Phosphoribosylformylglycinamidine synthase (PFAS), V-type proton ATPase catalytic subunit A (ATP6V1A), Thioredoxin domain-containing protein 5 (TXNDC5), 4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1), Dual specificity mitogen-activated protein kinase (MAP2K4), Calcineurin-like phosphoesterase domain-containing (CPPED1), Dual specificity protein phosphatase 12 (DUSP12), Phosphoribosylformylglycinamidine synthase (PFAS), Diphosphomevalonate decarboxylase (MVD), D-3-phosphoglycerate dehydrogenase (PHGDH), Cell cycle checkpoint control protein RAD9A (RAD9A), Peroxiredoxin-1 (PRDX1), Sorbitol dehydrogenase (SORD), Peroxiredoxin-4 (PRDX4), AMP deaminase 2 (AMPD2), Isocitrate dehydrogenase (IDH1), Pyruvate carboxylase (mitochondrial) (PC), Integrin-linked kinase-associated serine/threonine (ILKAP), Methylmalonate-semialdehyde dehydrogenase (ALDH6A1), 26S proteasome non-ATPase regulatory subunit 14 (PSMD14), Thymidylate kinase (DTYMK), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphata (PFKFB2), Peroxiredoxin-5 (mitochondrial) (PRDX5), PDP1, Cathepsin B (CTSB), Transmembrane protease serine 12 (TMPRSS12), UDP-glucose 6-dehydrogenase (UGDH), Histidine triad nucleotide-binding protein 1 (HINT1), E3 ubiquitin-protein ligase UBR5 (UBR5), SAM domain and HD domain-containing protein 1 (SAMHD1), Probable tRNA threonylcarbamoyladenosine biosynthesis (OSGEP), Methylated-DNA-protein-cysteine methyltransferase (MGMT), Fatty acid synthase (FASN), Adenosine deaminase (ADA), Cyclin-dependent kinase 19 (CDK19), Serine/threonine-protein kinase 38 (STK38), Mitogen-activated protein kinase 9 (MAPK9), tRNA (adenine(58)-N(1))-methyltransferase catalytic (TRMT61A), Glyoxylate reductase/hydroxypyruvate reductase (GRHPR), Aldehyde dehydrogenase (mitochondrial) (ALDH2), Mitochondrial-processing peptidase subunit beta (PMPCB), 3-ketoacyl-CoA thiolase, peroxisomal (ACAA1), Lysophosphatidic acid phosphatase type 6 (ACP6), Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6), Caspase-8 (CASP8), 2,5-phosphodiesterase 12 (PDE12), Thioredoxin domain-containing protein 12 (TXNDC12), Nitrilase homolog 1 (NIT1), ERO1-like protein alpha (ERO1L), SUMO-activating enzyme subunit 1 (SAE1), Leucine-tRNA ligase (cytoplasmic) (LARS), Protein-glutamine gamma-glutamyltransferase 2 (TGM2), Probable DNA dC-dU-editing enzyme APOBEC-3C (APOBEC3C), Double-stranded RNA-specific adenosine deaminase (ADAR), Isocitrate dehydrogenase (IDH2), Methylcrotonoyl-CoA carboxylase beta chain (mitochondrial) (MCCC2), Uridine phosphorylase 1 (UPP1), Glycogen phosphorylase (brain form) (PYGB), E3 ubiquitin-protein ligase UBR5 (UBR5), Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1), Ubiquitin carboxyl-terminal hydrolase 48 (USP48), Aconitate hydratase (mitochondrial) (ACO2), GMP reductase 2 (GMPR2), Pyrroline-5-carboxylate reductase 1 (mitochondrial) (PYCR1), Cathepsin Z (CTSZ), E3 ubiquitin-protein ligase UBR2 (UBR2), Cysteine protease ATG4B (ATG4B), Serine/threonine-protein kinase Nek9 (NEK9), Lysine-specific demethylase 4B (KDM4B), Insulin-degrading enzyme (IDE), Dipeptidyl peptidase 9 (DPP9), Decaprenyl-diphosphate synthase subunit 2 (PDSS2), TFIIH basal transcription factor complex helicase (ERCC3), Methionine-R-sulfoxide reductase B2 (mitochondrial) (MSRB2), E3 ubiquitin-protein ligase BRE1B (RNF40), Thymidylate synthase (TYMS), Cyclin-dependent kinase 5 (CDK5), Bifunctional 3-phosphoadenosine 5-phosphosulfate (PAPSS2), Short/branched chain specific acyl-CoA dehydrogenase (ACADSB), Cathepsin D (CTSD), E3 ubiquitin-protein ligase HUWE1 (HUWE1), Calpain-2 catalytic subunit (CAPN2), Dual specificity mitogen-activated protein kinase (MAP2K7), Mitogen-activated protein kinase kinase kinase MLT (MLTK), Bleomycin hydrolase (BLMH), Probable ATP-dependent RNA helicase DDX59 (DDX59), Cystathionine gamma-lyase (CTH), S-adenosylmethionine synthase isoform type-2 (MAT2A), 6-phosphofructokinase type C (PFKP), Cytidine deaminase (CDA), DNA-directed RNA polymerase II subunit RPB2 (POLR2B), Protein disulfide-isomerase (P4HB), Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3), Nucleoside diphosphate-linked moiety X motif 8 (mitochondrial) (NUDT8), E3 ubiquitin-protein ligase HUWE1 (HUWE1), Methylated-DNA-protein-cysteine methyltransferase (MGMT), Nitrilase homolog 1 (NIT1), Interferon regulatory factor 2-binding protein 1 (IRF2BP1), Ubiquitin carboxyl-terminal hydrolase 16 (USP16), Glycylpeptide N-tetradecanoyltransferase 2 (NMT2), Cyclin-dependent kinase inhibitor 3 (CDKN3), Hydroxysteroid dehydrogenase-like protein 2 (HSDL2), Serine/threonine-protein kinase VRK1 (VRK1), Serine/threonine-protein kinase A-Raf (ARAF), ATP-citrate synthase (ACLY), Probable ribonuclease ZC3H12D (ZC3HI2D), Peripheral plasma membrane protein CASK (CASK), DNA polymerase epsilon subunit 3 (POLE3), Aldehyde dehydrogenase X (mitochondrial) (ALDHIB1), UDP-N-acetylglucosamine transferase subunit ALG3 (ALG3), Protein disulfide-isomerase A4 (PDIA4), DNA polymerase alpha catalytic subunit (POLA1), Ethylmalonyl-CoA decarboxylase (ECHDC 1), Protein-tyrosine kinase 2-beta (PTK2B), E3 SUMO-protein ligase RanBP2 (RANBP2), Legumain (LGMN), Non-specific lipid-transfer protein (SCP2), Long-chain-fatty-acid-CoA ligase 4 (ACSL4), Dual specificity protein phosphatase 12 (DUSP12), Oxidoreductase HTATIP2 (HTATIP2), Serine/threonine-protein kinase MRCK beta (CDC42BPB), Histone-lysine N-methyltransferase EZH2 (EZH2), Non-specific lipid-transfer protein (SCP2), Dual specificity mitogen-activated protein kinase (MAP2K7), Ubiquitin carboxyl-terminal hydrolase 28 (USP28), 6-phosphofructokinase (liver type) (PFKL), SWI/SNF-related matrix-associated actin-dependent (SMARCAD1), Protein phosphatase methylesterase 1 (PPME1), DNA replication licensing factor MCM5 (MCM5), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphata (PFKFB4), Dehydrogenase/reductase SDR family member 11 (DHRS11), Pyroglutamyl-peptidase 1 (PGPEP1), Probable E3 ubiquitin-protein ligase (MYCBP2), DNA fragmentation factor subunit beta (DFFB), Deubiquitinating protein VCIP135 (VCPIP1), Putative transferase CAF17 (mitochondrial) (IBA57), Calpain-7 (CAPN7), GDP-L-fucose synthase (TSTA3), Protein disulfide-isomerase A4 (PDIA4, Probable ATP-dependent RNA helicase (DDX59), RNA exonuclease 4 (REXO4), PDK1, E3 SUMO-protein ligase (PIAS4), DNA (cytosine-5)-methyltransferase 1 (DNMT1), Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1), Hydroxymethylglutaryl-CoA synthase (cytoplasmic) (HMGCS1), E3 ubiquitin-protein ligase (SMURF2), Aldehyde dehydrogenase X (mitochondrial) (ALDHIB1), Tyrosine-protein kinase (BTK), DNA repair protein RAD50 (RAD50), ATP-binding domain-containing protein 4 (ATPBD4), Nucleoside diphosphate kinase 3 (NME3), Interleukin-1 receptor-associated kinase 1 (IRAK1), Ribonuclease P/MRP protein subunit POP5 (POP5), Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin (NGLY1), Caspase-2 (CASP2), Ribosomal protein S6 kinase alpha-3 (RPS6KA3), E3 ubiquitin-protein ligase UBR1 (UBR1), Serine/threonine-protein kinase Chk2 (CHEK2), Phosphatidylinositol 3,4,5-trisphosphate 5-phospha (INPPL1), Histone acetyltransferase p300 (EP300), Creatine kinase U-type (mitochondrial) (CKMT1B), E3 ubiquitin-protein ligase TRIM33 (TRIM33), Cancer-related nucleoside-triphosphatase (NTPCR), Aconitate hydratase (mitochondrial) (ACO2), Ubiquitin carboxyl-terminal hydrolase 34 (USP34), Probable E3 ubiquitin-protein ligase HERC4 (HERC4), E3 ubiquitin-protein ligase HECTD1 (HECTD1), Peroxisomal 2,4-dienoyl-CoA reductase (DECR2), Helicase ARIP4 (RAD54L2), Ubiquitin-like modifier-activating enzyme 7 (UBA7), ER degradation-enhancing alpha-mannosidase-like 3 (EDEM3), Ubiquitin-conjugating enzyme E20 (UBE20), Dual specificity mitogen-activated protein kinase (MAP2K7), Myotubularin-related protein 1 (MTMR1), Calcium-dependent phospholipase A2 (PLA2G5), Mitotic checkpoint serine/threonine-protein kinase (BUB1B), Putative transferase CAF17 (mitochondrial) (IBA57), Tyrosine-protein kinase ZAP-70 (ZAP70), E3 ubiquitin-protein ligase pellino homolog 1 (PELI1), Neuropathy target esterase (PNPLA6), Ribosomal protein S6 kinase alpha-3 (RPS6KA3), N6-adenosine-methyltransferase 70 kDa subunit (METTL3), Fructosamine-3-kinase (FN3K), Ubiquitin carboxyl-terminal hydrolase 22 (USP22), Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1), Caspase-5 (CASP5), L-2-hydroxyglutarate dehydrogenase (mitochondrial) (L2HGDH), Saccharopine dehydrogenase-like oxidoreductase (SCCPDH), FLAD1 FAD synthase, Lysine-specific demethylase 3A (KDM3A), or Ubiquitin carboxyl-terminal hydrolase 34 (USP34).


In some embodiments, the cysteine-containing protein is a signaling protein. In some instances, exemplary signaling protein includes vascular endothelial growth factor (VEGF) proteins or proteins involved in redox signaling. Exemplary VEGF proteins include VEGF-A, VEGF-B, VEGF-C, VEGF-D, and PGF. Exemplary proteins involved in redox signaling include redox-regulatory protein FAM213A.


In some embodiments, the cysteine-containing protein is a transcription factor or regulator. Exemplary cysteine-containing proteins as transcription factors and regulators include, but are not limited to, 40S ribosomal protein S3 (RPS3), Basic leucine zipper and W2 domain-containing protein (BZW1), Poly(rC)-binding protein 1 (PCBP1), 40S ribosomal protein S11 (RPS11), 40S ribosomal protein S4, X isoform (RPS4X), Signal recognition particle 9 kDa protein (SRP9), Non-POU domain-containing octamer-binding protein (NONO), N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15), Cleavage stimulation factor subunit 2 (CSTF2), Lamina-associated polypeptide 2, isoform alpha (TMPO), Heterogeneous nuclear ribonucleoprotein R (HNRNPR), MMS19 nucleotide excision repair protein homolog (MMS19), SWI/SNF complex subunit SMARCC2 (SMARCC2), Enhancer of mRNA-decapping protein 3 (EDC3), H/ACA ribonucleoprotein complex subunit 2 (NHP2), WW domain-containing adapter protein with coiled-c (WAC), N-alpha-acetyltransferase 15 NatA auxiliary subunit (NAA15), 40S ribosomal protein S11 (RPS11), Signal transducer and activator of transcription 1 (STAT1), Mediator of RNA polymerase II transcription subunit (MED15), Lamina-associated polypeptide 2 (isoform alpha) (TMPO), MMS19 nucleotide excision repair protein homolog (MMS19), DNA mismatch repair protein Msh2 (MSH2), Recombining binding protein suppressor of hairless (RBPJ), Mediator of RNA polymerase II transcription subunit (MED17), Heterogeneous nuclear ribonucleoprotein U (HNRNPU), Transcription initiation factor IIA subunit 2 (GTF2A2), Chromatin accessibility complex protein 1 (CHRAC1), CDKN2A-interacting protein (CDKN2AIP), Zinc finger protein 217 (ZNF217), Signal transducer and activator of transcription 3 (STAT3), WD repeat and HMG-box DNA-binding protein 1 (WDHD1), Lamina-associated polypeptide 2 (isoform alpha) (TMPO), Lamina-associated polypeptide 2 (isoforms beta/gam) (TMPO), Interferon regulatory factor 4 (IRF4), Protein flightless-1 homolog (FLI1), Heterogeneous nuclear ribonucleoprotein F (HNRNPF), Nucleus accumbens-associated protein 1 (NACC1), Transcription elongation regulator 1 (TCERG1), Protein HEXIM1 (HEXIM1), Enhancer of mRNA-decapping protein (EDC3), Zinc finger protein Aiolos (IKZF3), Transcription elongation factor SPT5 (SUPT5H), Forkhead box protein K1 (FOXK1), LIM domain-containing protein 1 (LIMD1), MMS19 nucleotide excision repair protein homolog (MMS19), Elongator complex protein 4 (ELP4), Ankyrin repeat and KH domain-containing protein 1 (ANKHD1), PML, Nuclear factor NF-kappa-B p100 subunit (NFKB2), Heterogeneous nuclear ribonucleoprotein L-like (HNRPLL), CCR4-NOT transcription complex subunit 3 (CNOT3), Constitutive coactivator of PPAR-gamma-like protein (FAMI20A), Mediator of RNA polymerase II transcription subunit (MED15), 60S ribosomal protein L7 (RPL7), Interferon regulatory factor 8 (IRF8), COUP transcription factor 2 (NR2F2), Mediator of RNA polymerase II transcription subunit (MED1), tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A), Transcription factor p65 (RELA), Exosome complex component RRP42 (EXOSC7), General transcription factor 3C polypeptide 1 (GTF3C1), Mothers against decapentaplegic homolog 2 (SMAD2), Ankyrin repeat domain-containing protein 17 (ANKRD17), MMS19 nucleotide excision repair protein homolog (MMS19), Death domain-associated protein 6 (DAXX), Zinc finger protein 318 (ZNF318), Thioredoxin-interacting protein (TXNIP), Glucocorticoid receptor (NR3C1), Iron-responsive element-binding protein 2 (IREB2), Zinc finger protein 295 (ZNF295), Polycomb protein SUZ12 (SUZ12), Cleavage stimulation factor subunit 2 tau variant (CSTF2T), C-myc promoter-binding protein (DENND4A), Pinin (PNN), Mediator of RNA polymerase II transcription subunit (MED9), POU domain, class 2, transcription factor 2 (POU2F2), Enhancer of mRNA-decapping protein 3 (EDC3), A-kinase anchor protein 1 (mitochondrial) (AKAP1), Transcription factor RelB (RELB), RNA polymerase II-associated protein 1 (RPAP1), Zinc finger protein 346 (ZNF346), Chromosome-associated kinesin KIF4A (KIF4A), Mediator of RNA polymerase II transcription subunit (MED12), Protein NPAT (NPAT), Leucine-rich PPR motif-containing protein (mitochondrial) (LRPPRC), AT-hook DNA-binding motif-containing protein 1 (AHDC1), Mediator of RNA polymerase II transcription subunit (MED12), Bromodomain-containing protein 8 (BRD8), Trinucleotide repeat-containing gene 6B protein (TNRC6B), Aryl hydrocarbon receptor nuclear translocator (ARNT), Activating transcription factor 7-interacting protein (ATF7IP), Glucocorticoid receptor (NR3C1), Chromosome transmission fidelity protein 18 homolog (CHTF18), or C-myc promoter-binding protein (DENND4A).


In some embodiments, the cysteine-containing protein is a channel, transporter, or receptor. Exemplary cysteine-containing proteins as channels, transporters, or receptors include, but are not limited to, Chloride intracellular channel protein 4 (CLIC4), Exportin-1 (XPO1), Thioredoxin (TXN), Protein SEC13 homolog (SEC13), Chloride intracellular channel protein 1 (CLIC1), Guanine nucleotide-binding protein subunit beta-2 (GNB2L1), Sorting nexin-6 (SNX6), Conserved oligomeric Golgi complex subunit 3 (COG3), Nuclear cap-binding protein subunit 1 (NCBP1), Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1), MOB-like protein phocein (MOB4), Programmed cell death 6-interacting protein (PDCD6IP), Glutaredoxin-1 (GLRX), ATP synthase subunit alpha (mitochondrial) (ATP5A1), Treacle protein (TCOF1), Dynactin subunit 1 (DCTN1), Importin-7 (IPO7), Exportin-2 (CSE1L), ATP synthase subunit gamma (mitochondrial) (ATP5C1), Trafficking protein particle complex subunit 5 (TRAPPC5), Thioredoxin mitochondrial (TXN2), THO complex subunit 6 homolog (THOC6), Exportin-1 (XPO1), Nuclear pore complex protein Nup50 (NUP50), Treacle protein (TCOF1), Nuclear pore complex protein Nup93 (NUP93), Nuclear pore glycoprotein p62 (NUP62), Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1), Thioredoxin-like protein 1 (TXNL1), Nuclear pore complex protein Nup214 (NUP214), Protein lin-7 homolog C (LIN7C), ADP-ribosylation factor-binding protein GGA2 (GGA2), Trafficking protein particle complex subunit 4 (TRAPPC4), Protein quaking (QK1), Perilipin-3 (PLIN3), Copper transport protein ATOX1 (ATOX1), Unconventional myosin-Ic (MYO1C), Nucleoporin NUP53 (NUP35), Vacuolar protein sorting-associated protein 18 homolog (VPS18), Dedicator of cytokinesis protein 7 (DOCK7), Nucleoporin p54 (NUP54), Ras-related GTP-binding protein C (RRAGC), Arf-GAP with Rho-GAP domain (ANK repeat and PH domain) (ARAP1), Exportin-5 (XPO5), Kinectin (KTN1), Chloride intracellular channel protein 6 (CLIC6), Voltage-gated potassium channel subunit beta-2 (KCNAB2), Exportin-5 (XPO5), Ras-related GTP-binding protein C (RRAGC), Ribosome-binding protein 1 (RRBP1), Acyl-CoA-binding domain-containing protein 6 (ACBD6), Chloride intracellular channel protein 5 (CLIC5), Pleckstrin homology domain-containing family A member (PLEKHA2), ADP-ribosylation factor-like protein 3 (ARL3), Protein transport protein Sec24C (SEC24C), Voltage-dependent anion-selective channel protein (VDAC3), Programmed cell death 6-interacting protein (PDCD6IP), Chloride intracellular channel protein 3 (CLIC3), Multivesicular body subunit 12A (FAM125A), Eukaryotic translation initiation factor 4E transporter (EIF4ENIF1), NmrA-like family domain-containing protein 1 (NMRAL1), Nuclear pore complex protein Nup98-Nup96 (NUP98), Conserved oligomeric Golgi complex subunit 1 (COG1), Importin-4 (IPO4), Pleckstrin homology domain-containing family A member (PLEKHA2), Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1), DENN domain-containing protein 1C (DENND1C), Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1), Protein ELYS (AHCTF1), Trafficking protein particle complex subunit 1 (TRAPPC1), Guanine nucleotide-binding protein-like 3 (GNL3), or Importin-13 (IPO13).


In some embodiments, the cysteine-containing protein is a chaperone. Exemplary cysteine-containing proteins as chaperones include, but are not limited to, 60 kDa heat shock protein (mitochondrial) (HSPD1), T-complex protein 1 subunit eta (CCT7), T-complex protein 1 subunit epsilon (CCT5), Heat shock 70 kDa protein 4 (HSPA4), GrpE protein homolog 1 (mitochondrial) (GRPEL1), Tubulin-specific chaperone E (TBCE), Protein unc-45 homolog A (UNC45A), Serpin H1 (SERPINH1), Tubulin-specific chaperone D (TBCD), Peroxisomal biogenesis factor 19 (PEXI9), BAG family molecular chaperone regulator 5 (BAGS), T-complex protein 1 subunit theta (CCT8), Protein canopy homolog 3 (CNPY3), DnaJ homolog subfamily C member 10 (DNAJC10), ATP-dependent Clp protease ATP-binding subunit clp (CLPX), or Midasin (MDN1).


In some embodiments, the cysteine-containing protein is an adapter, scaffolding, or modulator protein. Exemplary cysteine-containing proteins as adapter, scaffolding, or modulator proteins include, but are not limited to, Proteasome activator complex subunit 1 (PSME1), TIP41-like protein (TIPRL), Crk-like protein (CRKL), Cofilin-1 (CFL1), Condensin complex subunit 1 (NCAPD2), Translational activator GCN1 (GCNIL1), Serine/threonine-protein phosphatase 2A 56 kDa regulatory (PPP2R5D), UPF0539 protein C7orf59 (C7orf59), Protein diaphanous homolog 1 (DIAPH1), Protein asunder homolog (Asun), Ras GTPase-activating-like protein IQGAP1 (IQGAP1), Sister chromatid cohesion protein PDS5 homolog A (PDS5A), Reticulon-4 (RTN4), Proteasome activator complex subunit 4 (PSME4), Condensin complex subunit 2 (NCAPH), Sister chromatid cohesion protein PDS5 homolog A (PDS5A), cAMP-dependent protein kinase type I-alpha regulatory (PRKAR1A), Host cell factor 1 (HCFC1), Serine/threonine-protein phosphatase 4 regulatory (PPP4R2), Apoptotic chromatin condensation inducer in the nucleus (ACIN1), BRISC and BRCA1-A complex member 1 (BABAM1), Interferon-induced protein with tetratricopeptide (IFIT3), Ras association domain-containing protein 2 (RASSF2), Hsp70-binding protein 1 (HSPBP1), TBC1 domain family member 15 (TBC1D15), Dynamin-binding protein (DNMBP), Condensin complex subunit 1 (NCAPD2), Beta-2-syntrophin (SNTB2), Disks large homolog 1 (DLG1), TBC1 domain family member 13 (TBC1D13), Formin-binding protein 1-like (FNBP1L), Translational activator GCN1 (GCN1L1), GRB2-related adapter protein (GRAP), G2/mitotic-specific cyclin-B1 (CCNB 1), Myotubularin-related protein 12 (MTMR12), Protein FADD (FADD), Translational activator GCN1 (GCN1L1), Wings apart-like protein homolog (WAPAL), cAMP-dependent protein kinase type U-beta regulatory (PRKAR2B), Malcavernin (CCM2), MPP1 55 kDa erythrocyte membrane protein, Actin filament-associated protein 1 (AFAP1), Tensin-3 (TNS3), tRNA methyltransferase 112 homolog (TRMT112), Symplekin (SYMPK), TBC1 domain family member 2A (TBC1D2), ATR-interacting protein (ATRIP), Ataxin-10 (ATXN10), Succinate dehydrogenase assembly factor 2 (mitochondrial) (SDHAF2), Formin-binding protein 1 (FNBP1), Myotubularin-related protein 12 (MTMR12), Interferon-induced protein with tetratricopeptide (IFIT3), Protein CBFA2T2 (CBFA2T2), Neutrophil cytosol factor 1 (NCF1), or Protein syndesmos (NUDT16L1).


In some embodiments, a cysteine-containing polypeptide comprises a protein illustrated in Tables 1-5. In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Table 1. In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Table 2. In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Table 3. In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Table 4. In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Table 5.


In some embodiments, a cysteine-containing polypeptide comprises a protein illustrated in Tables 6A-6E. In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Table 6A. In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Table 6B. In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Table 6C. In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Table 6D. In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Table 6E.


In some embodiments, a cysteine-containing polypeptide comprises cereblon. Cereblon is a substrate receptor that interacts with the protein adaptor damaged DNA binding protein 1 (DDB1), scaffold Cullin-4A (CUL4A), and regulator of cullins 1 (ROC1) to form an E3 ubiquitin ligase complex. The cereblon-E3 ligase complex is involved in targeting a plurality of substrates for ubiquitination, which are then subsequently degraded by proteasomes. In some instances, thalidomide and related immunomodulatory (IMiD) compounds such as lenalidomide and pomalidomide promote and modulate cereblon recruitment of neosubstrates. For example, a cereblon modulator CC-220 has been shown to improve degradation of Ikaros and Aiolos, two zinc finger transcription factors that have been implicated in lymphoid development and differentiation (Matyskiela, et al., “A cereblon modulator (CC-220) with improved degradation of Ikaros and Aiolos,” J Med Chem. Apr. 20, 2017). Further, dBET1, a bifunctional phthalimide-conjugated ligand which is a substrate for cereblon, also selectively targets BRD4, a transcriptional coactivator, for degradation.


In some instances, cereblon is a eukaryotic protein ranging from 400-600 residues in length. The human cereblon (SEQ ID NO: 9665), which is about 442 residues in length, is encoded by the CRBN gene. The cereblon protein comprises a central LON domain (residues 80-317) followed by a C-terminal CULT domain. The LON domain is further subdivided into an N-terminal LON-N subdomain, a four helix bundle, and a C-terminal LON-C subdomain.


In some embodiments, a small molecule fragment described herein binds to a cysteine residue within cereblon. In some cases, a small molecule fragment described herein binds to a cysteine residue in the LON domain of cereblon. In some cases, a small molecule fragment described herein binds to a cysteine residue in the LON-N domain of cereblon. In some cases, a small molecule fragment described herein binds to a cysteine residue in the LON-C domain of cereblon. In other cases, a small molecule fragment described herein binds to a cysteine residue in the CULT domain of cereblon. In some instances, a small molecule fragment described herein binds to cysteine residue 188 of cereblon, wherein residue position 188 corresponds to position 188 of SEQ ID NO: 9665. In some instances, a small molecule fragment described herein binds to cysteine residue 287 of cereblon, wherein residue position 287 corresponds to position 287 of SEQ ID NO: 9665.


In some embodiments, described herein is a method of modulating cereblon activity, which comprises contacting a cell expressing cereblon with a small molecule fragment of Formula (I):




embedded image


wherein RM is a reactive moiety selected from a Michael acceptor moiety, a leaving group moiety, or a moiety capable of forming a covalent bond with the thiol group of cysteine residue; and F is a small molecule fragment moiety; wherein the small molecule fragment of Formula (I) covalently binds to residue 187 or residue 288 of cereblon; and wherein residue positions 187 and 288 correspond to positions 187 and 288 of SEQ ID NO: 9665. In some instances, F is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B). In some instances, F optionally comprises a second reactive moiety. In some cases, the cell is a mammalian cell. In some cases, the method is an in vivo method.


Polypeptides Comprising a Cysteine Interacting Site

In some embodiments, a cysteine-containing polypeptide comprises a polypeptide that is at most 50 amino acid residues in length. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 70% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 75% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 80% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 85% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 90% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 91% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 92% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 93% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 94% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 95% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 96% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 97% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 98% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 99% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising 100% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide consisting of 100% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655.


In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 70% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 75% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 80% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 85% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 90% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 91% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 92% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 93% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 94% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 95% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 96% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 97% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 98% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 99% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising 100% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 1607.


In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity to SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising 100% sequence identity to SEQ ID NO: 1607. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide consisting of 100% sequence identity to SEQ ID NO: 1607.


In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity to at: least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 70% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 75% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 80% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 85% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 90% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 91% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 92% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 93% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 94% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 95% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 96% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 97% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 98% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 99% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising 100% sequence identity to at least seven contiguous amino acids of SEQ ID NO: 6311.


In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity to SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising 100% sequence identity to SEQ ID NO: 6311. In some embodiments, a cysteine-containing polypeptide comprises an isolated and purified polypeptide consisting of 100% sequence identity to SEQ ID NO: 6311.


As used herein, a polypeptide includes natural amino acids, unnatural amino acids, or a combination thereof. In some instances, an amino acid residue refers to a molecule containing both an amino group and a carboxyl group. Suitable amino acids include, without limitation, both the D- and L-isomers of the naturally-occurring amino acids, as well as non-naturally occurring amino acids prepared by organic synthesis or other metabolic routes. The term amino acid, as used herein, includes, without limitation, α-amino acids, natural amino acids, non-natural amino acids, and amino acid analogs.


The term “α-amino acid” refers to a molecule containing both an amino group and a carboxyl group bound to a carbon which is designated the α-carbon.


The term “β-amino acid” refers to a molecule containing both an amino group and a carboxyl group in a β configuration.


“Naturally occurring amino acid” refers to any one of the twenty amino acids commonly found in peptides synthesized in nature, and known by the one letter abbreviations A, R, N, C, D, Q, E, G, H, I, L, K, M, F, P, S, T, W, Y, and V.


“Hydrophobic amino acids” include small hydrophobic amino acids and large hydrophobic amino acids. “Small hydrophobic amino acid” are glycine, alanine, proline, and analogs thereof. “Large hydrophobic amino acids” are valine, leucine, isoleucine, phenylalanine, methionine, tryptophan, and analogs thereof. “Polar amino acids” are serine, threonine, asparagine, glutamine, cysteine, tyrosine, and analogs thereof. “Charged amino acids” are lysine, arginine, histidine, aspartate, glutamate, and analogs thereof.


The term “amino acid analog” refers to a molecule which is structurally similar to an amino acid and which is substituted for an amino acid in the formation of a peptidomimetic macrocycle. Amino acid analogs include, without limitation, p-amino acids and amino acids where the amino or carboxy group is substituted by a similarly reactive group (e.g., substitution of the primary amine with a secondary or tertiary amine, or substitution of the carboxy group with an ester).


The term “non-natural amino acid” refers to an amino acid which is not one of the twenty amino acids commonly found in peptides synthesized in nature, and known by the one letter abbreviations A, R, N, C, D, Q, E, G, H, I, L, K, M, F, P, S, T, W, Y, and V.


In some instances, amino acid analogs include 1-amino acid analogs. Examples of β-amino acid analogs include, but are not limited to, the following: cyclic p-amino acid analogs; 3-alanine; (R)-β-phenylalanine; (R)-1,2,3,4-tetrahydro-isoquinoline-3-acetic acid; (R)-3-amino-4-(1-naphthyl)-butyric acid; (R)-3-amino-4-(2,4-dichlorophenyl)butyric acid; (R)-3-amino-4-(2-chlorophenyl)-butyric acid; (R)-3-amino-4-(2-cyanophenyl)-butyric acid; (R)-3-amino-4-(2-fluorophenyl)-butyric acid; (R)-3-amino-4-(2-furyl)-butyric acid; (R)-3-amino-4-(2-methylphenyl)-butyric acid; (R)-3-amino-4-(2-naphthyl)-butyric acid; (R)-3-amino-4-(2-thienyl)-butyric acid; (R)-3-amino-4-(2-trifluoromethylphenyl)-butyric acid; (R)-3-amino-4-(3,4-dichlorophenyl)butyric acid; (R)-3-amino-4-(3,4-difluorophenyl)butyric acid; (R)-3-amino-4-(3-benzothienyl)-butyric acid; (R)-3-amino-4-(3-chlorophenyl)-butyric acid; (R)-3-amino-4-(3-cyanophenyl)-butyric acid; (R)-3-amino-4-(3-fluorophenyl)-butyric acid; (R)-3-amino-4-(3-methylphenyl)-butyric acid; (R)-3-amino-4-(3-pyridyl)-butyric acid; (R)-3-amino-4-(3-thienyl)-butyric acid; (R)-3-amino-4-(3-trifluoromethylphenyl)-butyric acid; (R)-3-amino-4-(4-bromophenyl)-butyric acid; (R)-3-amino-4-(4-chlorophenyl)-butyric acid; (R)-3-amino-4-(4-cyanophenyl)-butyric acid; (R)-3-amino-4-(4-fluorophenyl)-butyric acid; (R)-3-amino-4-(4-iodophenyl)-butyric acid; (R)-3-amino-4-(4-methylphenyl)-butyric acid; (R)-3-amino-4-(4-nitrophenyl)-butyric acid; (R)-3-amino-4-(4-pyridyl)-butyric acid; (R)-3-amino-4-(4-trifluoromethylphenyl)-butyric acid; (R)-3-amino-4-pentafluoro-phenylbutyric acid; (R)-3-amino-5-hexenoic acid; (R)-3-amino-5-hexynoic acid; (R)-3-amino-5-phenylpentanoic acid; (R)-3-amino-6-phenyl-5-hexenoic acid; (S)-1,2,3,4-tetrahydro-isoquinoline-3-acetic acid; (S)-3-amino-4-(1-naphthyl)-butyric acid; (S)-3-amino-4-(2,4-dichlorophenyl)butyric acid; (S)-3-amino-4-(2-chlorophenyl)-butyric acid; (S)-3-amino-4-(2-cyanophenyl)-butyric acid; (S)-3-amino-4-(2-fluorophenyl)-butyric acid; (S)-3-amino-4-(2-furyl)-butyric acid; (S)-3-amino-4-(2-methylphenyl)-butyric acid; (S)-3-amino-4-(2-naphthyl)-butyric acid; (S)-3-amino-4-(2-thienyl)-butyric acid; (S)-3-amino-4-(2-trifluoromethylphenyl)-butyric acid; (S)-3-amino-4-(3,4-dichlorophenyl)butyric acid; (S)-3-amino-4-(3,4-difluorophenyl)butyric acid; (S)-3-amino-4-(3-benzothienyl)-butyric acid; (S)-3-amino-4-(3-chlorophenyl)-butyric acid; (S)-3-amino-4-(3-cyanophenyl)-butyric acid; (S)-3-amino-4-(3-fluorophenyl)-butyric acid; (S)-3-amino-4-(3-methylphenyl)-butyric acid; (S)-3-amino-4-(3-pyridyl)-butyric acid; (S)-3-amino-4-(3-thienyl)-butyric acid; (S)-3-amino-4-(3-trifluoromethylphenyl)-butyric acid; (S)-3-amino-4-(4-bromophenyl)-butyric acid; (S)-3-amino-4-(4-chlorophenyl) butyric acid; (S)-3-amino-4-(4-cyanophenyl)-butyric acid; (S)-3-amino-4-(4-fluorophenyl) butyric acid; (S)-3-amino-4-(4-iodophenyl)-butyric acid; (S)-3-amino-4-(4-methylphenyl)-butyric acid; (S)-3-amino-4-(4-nitrophenyl)-butyric acid; (S)-3-amino-4-(4-pyridyl)-butyric acid; (S)-3-amino-4-(4-trifluoromethylphenyl)-butyric acid; (S)-3-amino-4-pentafluoro-phenylbutyric acid; (S)-3-amino-5-hexenoic acid; (S)-3-amino-5-hexynoic acid; (S)-3-amino-5-phenylpentanoic acid; (S)-3-amino-6-phenyl-5-hexenoic acid; 1,2,5,6-tetrahydropyridine-3-carboxylic acid; 1,2,5,6-tetrahydropyridine-4-carboxylic acid; 3-amino-3-(2-chlorophenyl)-propionic acid; 3-amino-3-(2-thienyl)-propionic acid; 3-amino-3-(3-bromophenyl)-propionic acid; 3-amino-3-(4-chlorophenyl)-propionic acid; 3-amino-3-(4-methoxyphenyl)-propionic acid; 3-amino-4,4,4-trifluoro-butyric acid; 3-aminoadipic acid; D-3-phenylalanine; 3-leucine; L-β-homoalanine; L-β-homoaspartic acid γ-benzyl ester; L-β-homoglutamic acid δ-benzyl ester; L-β-homoisoleucine; L-β-homoleucine; L-β-homomethionine; L-β-homophenylalanine; L-β-homoproline; L-β-homotryptophan; L-β-homovaline; L-Nω-benzyloxycarbonyl-β-homolysine; Nω-L-β-homoarginine; O-benzyl-L-β-homohydroxyproline; O-benzyl-L-O-homoserine; O-benzyl-L-β-homothreonine; O-benzyl-L-β-homotyrosine; γ-trityl-L-O-homoasparagine; (R)-β-phenylalanine; L-β-homoaspartic acid γ-t-butyl ester; L-β-homoglutamic acid δ-t-butyl ester; L-Nω-β-homolysine; Nδ-trityl-L-β-homoglutamine; No-2,2,4,6,7-pentamethyl-dihydrobenzofuran-5-sulfonyl-L-β-homoarginine; O-t-butyl-L-β-homohydroxy-proline; O-t-butyl-L-β-homoserine; O-t-butyl-L-β-homothreonine; O-t-butyl-L-β-homotyrosine; 2-aminocyclopentane carboxylic acid; and 2-aminocyclohexane carboxylic acid.


In some instances, amino acid analogs include analogs of alanine, valine, glycine, or leucine. Examples of amino acid analogs of alanine, valine, glycine, and leucine include, but are not limited to, the following: α-methoxyglycine; α-allyl-L-alanine; α-aminoisobutyric acid; α-methyl-leucine; β-(1-naphthyl)-D-alanine; β-(1-naphthyl)-L-alanine; β-(2-naphthyl)-D-alanine; β-(2-naphthyl)-L-alanine; β-(2-pyridyl)-D-alanine; β-(2-pyridyl)-L-alanine; β-(2-thienyl)-D-alanine; β-(2-thienyl)-L-alanine; β-(3-benzothienyl)-D-alanine; β-(3-benzothienyl)-L-alanine; β-(3-pyridyl)-D-alanine; β-(3-pyridyl)-L-alanine; β-(4-pyridyl)-D-alanine; β-(4-pyridyl)-L-alanine; β-chloro-L-alanine; β-cyano-L-alanin; β-cyclohexyl-D-alanine; β-cyclohexyl-L-alanine; β-cyclopenten-1-yl-alanine; β-cyclopentyl-alanine; β-cyclopropyl-L-Ala-OH.dicyclohexylammonium salt; β-t-butyl-D-alanine; β-t-butyl-L-alanine; γ-aminobutyric acid; L-α,β-diaminopropionic acid; 2,4-dinitro-phenylglycine; 2,5-dihydro-D-phenylglycine; 2-amino-4,4,4-trifluorobutyric acid; 2-fluoro-phenylglycine; 3-amino-4,4,4-trifluoro-butyric acid; 3-fluoro-valine; 4,4,4-trifluoro-valine; 4,5-dehydro-L-leu-OH.dicyclohexylammonium salt; 4-fluoro-D-phenylglycine; 4-fluoro-L-phenylglycine; 4-hydroxy-D-phenylglycine; 5,5,5-trifluoro-leucine; 6-aminohexanoic acid; cyclopentyl-D-Gly-OH.dicyclohexylammonium salt; cyclopentyl-Gly-OH.dicyclohexylammonium salt; D-α,β-diaminopropionic acid; D-α-aminobutyric acid; D-α-t-butylglycine; D-(2-thienyl)glycine; D-(3-thienyl)glycine; D-2-aminocaproic acid; D-2-indanylglycine; D-allylglycine-dicyclohexylammonium salt; D-cyclohexylglycine; D-norvaline; D-phenylglycine; β-aminobutyric acid; β-aminoisobutyric acid; (2-bromophenyl)glycine; (2-methoxyphenyl)glycine; (2-methylphenyl)glycine; (2-thiazoyl)glycine; (2-thienyl)glycine; 2-amino-3-(dimethylamino)-propionic acid; L-α,β-diaminopropionic acid; L-α-aminobutyric acid; L-α-t-butylglycine; L-(3-thienyl)glycine; L-2-amino-3-(dimethylamino)-propionic acid; L-2-aminocaproic acid dicyclohexyl-ammonium salt; L-2-indanylglycine; L-allylglycine.dicyclohexyl ammonium salt; L-cyclohexylglycine; L-phenylglycine; L-propargylglycine; L-norvaline; N-α-aminomethyl-L-alanine; D-α,γ-diaminobutyric acid; L-α,γ-diaminobutyric acid; β-cyclopropyl-L-alanine; (N-β-(2,4-dinitrophenyl))-L-α,β-diaminopropionic acid; (N-β-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl)-D-α,β-diaminopropionic acid; (N-β-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl)-L-α,β-diaminopropionic acid; (N-β-4-methyltrityl)-L-α,β-diaminopropionic acid; (N-β-allyloxycarbonyl)-L-α,β-diaminopropionic acid; (N-γ-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl)-D-α,γ-diaminobutyric acid; (N-γ-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl)-L-α,γ-diaminobutyric acid; (N-γ-4-methyltrityl)-D-α,γ-diaminobutyric acid; (N-γ-4-methyltrityl)-L-α,γ-diaminobutyric acid; (N-γ-allyloxycarbonyl)-L-α,γ-diaminobutyric acid; D-α,γ-diaminobutyric acid; 4,5-dehydro-L-leucine; cyclopentyl-D-Gly-OH; cyclopentyl-Gly-OH; D-allylglycine; D-homocyclohexylalanine; L-1-pyrenylalanine; L-2-aminocaproic acid; L-allylglycine; L-homocyclohexylalanine; and N-(2-hydroxy-4-methoxy-Bzl)-Gly-OH.


In some instances, amino acid analogs include analogs of arginine or lysine. Examples of amino acid analogs of arginine and lysine include, but are not limited to, the following: citrulline; L-2-amino-3-guanidinopropionic acid; L-2-amino-3-ureidopropionic acid; L-citrulline; Lys(Me)2-OH; Lys(N3)—OH; NS-benzyloxycarbonyl-L-ornithine; Nω-nitro-D-arginine; Nω-nitro-L-arginine; α-methyl-ornithine; 2,6-diaminoheptanedioic acid; L-ornithine; (Nδ-1-(4,4-dimethyl-2,6-dioxo-cyclohex-1-ylidene)ethyl)-D-ornithine; (Nδ-1-(4,4-dimethyl-2,6-dioxo-cyclohex-1-ylidene)ethyl)-L-ornithine; (Nδ-4-methyltrityl)-D-ornithine; (Nδ-4-methyltrityl)-L-omithine; D-ornithine; L-ornithine; Arg(Me)(Pbf)-OH; Arg(Me)2-OH (asymmetrical); Arg(Me)2-OH (symmetrical); Lys(ivDde)-OH; Lys(Me)2-OH.HCl; Lys(Me3)-OH chloride; Nω-nitro-D-arginine; and Nω-nitro-L-arginine.


In some instances, amino acid analogs include analogs of aspartic or glutamic acids. Examples of amino acid analogs of aspartic and glutamic acids include, but are not limited to, the following: α-methyl-D-aspartic acid; α-methyl-glutamic acid; α-methyl-L-aspartic acid; γ-methylene-glutamic acid; (N-γ-ethyl)-L-glutamine; [N-α-(4-aminobenzoyl)]-L-glutamic acid; 2,6-diaminopimelic acid; L-α-aminosuberic acid; D-2-aminoadipic acid; D-α-aminosuberic acid; α-aminopimelic acid; iminodiacetic acid; L-2-aminoadipic acid; threo-β-methyl-aspartic acid; γ-carboxy-D-glutamic acid γ,γ-di-t-butyl ester; γ-carboxy-L-glutamic acid γ,γ-di-t-butyl ester; Glu(OAll)-OH; L-Asu(OtBu)-OH; and pyroglutamic acid.


In some instances, amino acid analogs include analogs of cysteine and methionine. Examples of amino acid analogs of cysteine and methionine include, but are not limited to, Cys(farnesyl)-OH, Cys(farnesyl)-OMe, α-methyl-methionine, Cys(2-hydroxyethyl)-OH, Cys(3-aminopropyl)-OH, 2-amino-4-(ethylthio)butyric acid, buthionine, buthioninesulfoximine, ethionine, methionine methylsulfonium chloride, selenomethionine, cysteic acid, [2-(4-pyridyl)ethyl]-DL-penicillamine, [2-(4-pyridyl)ethyl]-L-cysteine, 4-methoxybenzyl-D-penicillamine, 4-methoxybenzyl-L-penicillamine, 4-methylbenzyl-D-penicillamine, 4-methylbenzyl-L-penicillamine, benzyl-D-cysteine, benzyl-L-cysteine, benzyl-DL-homocysteine, carbamoyl-L-cysteine, carboxyethyl-L-cysteine, carboxymethyl-L-cysteine, diphenylmethyl-L-cysteine, ethyl-L-cysteine, methyl-L-cysteine, t-butyl-D-cysteine, trityl-L-homocysteine, trityl-D-penicillamine, cystathionine, homocystine, L-homocystine, (2-aminoethyl)-L-cysteine, seleno-L-cysteine, cystathionine, Cys(StBu)-OH, and acetamidomethyl-D-penicillamine.


In some instances, amino acid analogs include analogs of phenylalanine and tyrosine. Examples of amino acid analogs of phenylalanine and tyrosine include β-methyl-phenylalanine, β-hydroxyphenylalanine, α-methyl-3-methoxy-DL-phenylalanine, α-methyl-D-phenylalanine, α-methyl-L-phenylalanine, 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, 2,4-dichloro-phenylalanine, 2-(trifluoromethyl)-D-phenylalanine, 2-(trifluoromethyl)-L-phenylalanine, 2-bromo-D-phenylalanine, 2-bromo-L-phenylalanine, 2-chloro-D-phenylalanine, 2-chloro-L-phenylalanine, 2-cyano-D-phenylalanine, 2-cyano-L-phenylalanine, 2-fluoro-D-phenylalanine, 2-fluoro-L-phenylalanine, 2-methyl-D-phenylalanine, 2-methyl-L-phenylalanine, 2-nitro-D-phenylalanine, 2-nitro-L-phenylalanine, 2;4;5-trihydroxy-phenylalanine, 3,4,5-trifluoro-D-phenylalanine, 3,4,5-trifluoro-L-phenylalanine, 3,4-dichloro-D-phenylalanine, 3,4-dichloro-L-phenylalanine, 3,4-difluoro-D-phenylalanine, 3,4-difluoro-L-phenylalanine, 3,4-dihydroxy-L-phenylalanine, 3,4-dimethoxy-L-phenylalanine, 3,5,3′-triiodo-L-thyronine, 3,5-diiodo-D-tyrosine, 3,5-diiodo-L-tyrosine, 3,5-diiodo-L-thyronine, 3-(trifluoromethyl)-D-phenylalanine, 3-(trifluoromethyl)-L-phenylalanine, 3-amino-L-tyrosine, 3-bromo-D-phenylalanine, 3-bromo-L-phenylalanine, 3-chloro-D-phenylalanine, 3-chloro-L-phenylalanine, 3-chloro-L-tyrosine, 3-cyano-D-phenylalanine, 3-cyano-L-phenylalanine, 3-fluoro-D-phenylalanine, 3-fluoro-L-phenylalanine, 3-fluoro-tyrosine, 3-iodo-D-phenylalanine, 3-iodo-L-phenylalanine, 3-iodo-L-tyrosine, 3-methoxy-L-tyrosine, 3-methyl-D-phenylalanine, 3-methyl-L-phenylalanine, 3-nitro-D-phenylalanine, 3-nitro-L-phenylalanine, 3-nitro-L-tyrosine, 4-(trifluoromethyl)-D-phenylalanine, 4-(trifluoromethyl)-L-phenylalanine, 4-amino-D-phenylalanine, 4-amino-L-phenylalanine, 4-benzoyl-D-phenylalanine, 4-benzoyl-L-phenylalanine, 4-bis(2-chloroethyl)amino-L-phenylalanine, 4-bromo-D-phenylalanine, 4-bromo-L-phenylalanine, 4-chloro-D-phenylalanine, 4-chloro-L-phenylalanine, 4-cyano-D-phenylalanine, 4-cyano-L-phenylalanine, 4-fluoro-D-phenylalanine, 4-fluoro-L-phenylalanine, 4-iodo-D-phenylalanine, 4-iodo-L-phenylalanine, homophenylalanine, thyroxine, 3,3-diphenylalanine, thyronine, ethyl-tyrosine, and methyl-tyrosine.


In some instances, amino acid analogs include analogs of proline. Examples of amino acid analogs of proline include, but are not limited to, 3,4-dehydro-proline, 4-fluoro-proline, cis-4-hydroxy-proline, thiazolidine-2-carboxylic acid, and trans-4-fluoro-proline.


In some instances, amino acid analogs include analogs of serine and threonine. Examples of amino acid analogs of serine and threonine include, but are not limited to, 3-amino-2-hydroxy-5-methylhexanoic acid, 2-amino-3-hydroxy-4-methylpentanoic acid, 2-amino-3-ethoxybutanoic acid, 2-amino-3-methoxybutanoic acid, 4-amino-3-hydroxy-6-methylheptanoic acid, 2-amino-3-benzyloxypropionic acid, 2-amino-3-benzyloxypropionic acid, 2-amino-3-ethoxypropionic acid, 4-amino-3-hydroxybutanoic acid, and α-methylserine.


In some instances, amino acid analogs include analogs of tryptophan. Examples of amino acid analogs of tryptophan include, but are not limited to, the following: α-methyl-tryptophan; β-(3-benzothienyl)-D-alanine; β-(3-benzothienyl)-L-alanine; 1-methyl-tryptophan; 4-methyl-tryptophan; 5-benzyloxy-tryptophan; 5-bromo-tryptophan; 5-chloro-tryptophan; 5-fluoro-tryptophan; 5-hydroxy-tryptophan; 5-hydroxy-L-tryptophan; 5-methoxy-tryptophan; 5-methoxy-L-tryptophan; 5-methyl-tryptophan; 6-bromo-tryptophan; 6-chloro-D-tryptophan; 6-chloro-tryptophan; 6-fluoro-tryptophan; 6-methyl-tryptophan; 7-benzyloxy-tryptophan; 7-bromo-tryptophan; 7-methyl-tryptophan; D-1,2,3,4-tetrahydro-norharman-3-carboxylic acid; 6-methoxy-1,2,3,4-tetrahydronorharman-1-carboxylic acid; 7-azatryptophan; L-1,2,3,4-tetrahydro-norharman-3-carboxylic acid; 5-methoxy-2-methyl-tryptophan; and 6-chloro-L-tryptophan.


In some instances, amino acid analogs are racemic. In some instances, the D isomer of the amino acid analog is used. In some cases, the L isomer of the amino acid analog is used. In some instances, the amino acid analog comprises chiral centers that are in the R or S configuration. Sometimes, the amino group(s) of a β-amino acid analog is substituted with a protecting group, e.g., tert-butyloxycarbonyl (BOC group), 9-fluorenylmethyloxycarbonyl (FMOC), tosyl, and the like. Sometimes, the carboxylic acid functional group of a β-amino acid analog is protected, e.g., as its ester derivative. In some cases, the salt of the amino acid analog is used.


Cysteine-Containing Polypeptide Production

In some embodiments, a cysteine-containing polypeptide described above is generated recombinantly or is synthesized chemically. In some instances, a cysteine-containing polypeptide described above is generated recombinantly, for example, by a host cell system or in a cell-free system. In some instances, a cysteine-containing polypeptide described above is synthesized chemically.


In some embodiments, a cysteine-containing polypeptide described above is generated recombinantly by a host cell system. Exemplary host cell systems include a eukaryotic cell system (e.g., mammalian cell, insect cell, yeast cell or plant cell) or a prokaryotic cell system (e.g., gram-positive bacterium or a gram-negative bacterium).


In some embodiments, a eukaryotic host cell is a mammalian host cell. In some cases, a mammalian host cell is a stable cell line, or a cell line that has incorporated a genetic material of interest into its own genome and has the capability to express the product of the genetic material after many generations of cell division. In other cases, a mammalian host cell is a transient cell line, or a cell line that has not incorporated a genetic material of interest into its own genome and does not have the capability to express the product of the genetic material after many generations of cell division.


Exemplary mammalian host cells include 293T cell line, 293A cell line, 293FT cell line, 293F cells, 293 H cells, A549 cells, MDCK cells, CHO DG44 cells, CHO-S cells, CHO-K1 cells, Expi293F™ cells, Flp-In™ T-REx™ 293 cell line, Flp-In™-293 cell line, Flp-In™-3T3 cell line, Flp-In™-BHK cell line, Flp-In™-CHO cell line, Flp-In™-CV-1 cell line, Flp-In™-Jurkat cell line, FreeStyle™ 293-F cells, FreeStyle™ CHO-S cells, GripTite™ 293 MSR cell line, GS-CHO cell line, HepaRG™ cells, T-REx™ Jurkat cell line, Per.C6 cells, T-REx™-293 cell line, T-REx™-CHO cell line, and T-REx™-HeLa cell line.


In some embodiments, a eukaryotic host cell is an insect host cell. Exemplary insect host cell include Drosophila S2 cells, Sf9 cells, Sf21 cells, High Five™ cells, and expresSF+® cells.


In some embodiments, a eukaryotic host cell is a yeast host cell. Exemplary yeast host cells include Pichia pastoris yeast strains such as GS 115, KM71H, SMD1168, SMD1168H, and X-33, and Saccharomyces cerevisiae yeast strains such as INVSc1.


In some embodiments, a eukaryotic host cell is a plant host cell. In some instances, the plant cells comprises a cell from algae. Exemplary plant cell lines include strains from Chlamydomonas reinhardtii 137c, or Synechococcus elongatus PPC 7942.


In some embodiments, a host cell is a prokaryotic host cell. Exemplary prokaryotic host cells include BL21, Mach1™, DH10B™, TOP10, DH5α, DH10Bac™, OmniMax™, MegaX™, DH12S™, INV110, TOP10F′, INVαF, TOP10/P3, ccdB Survival, PIR1, PIR2, Stbl2™, Stbl3™, or Stbl4™.


In some instances, suitable vectors for the production of a cysteine-containing polypeptide include any suitable vectors derived from either a eukaryotic or prokaryotic sources. Exemplary vectors include vectors from bacteria (e.g., E. coli), insects, yeast (e.g., Pichia pastoris), algae, or mammalian source. Bacterial vectors include, for example, pACYC177, pASK75, pBAD vector series, pBADM vector series, pET vector series, pETM vector series, pGEX vector series, pHAT, pHAT2, pMal-c2, pMal-p2, pQE vector series, pRSET A, pRSET B, pRSET C, pTrcHis2 series, pZA31-Luc, pZE21-MCS-1, pFLAG ATS, pFLAG CTS, pFLAG MAC, pFLAG Shift-12c, pTAC-MAT-1, pFLAG CTC, or pTAC-MAT-2.


Insect vectors include, for example, pFastBac1, pFastBac DUAL, pFastBac ET, pFastBac HTa, pFastBac HTb, pFastBac HTc, pFastBac M30a, pFastBact M30b, pFastBac, M30c, pVL1392, pVL1393, pVL1393 M10, pVL1393 M11, pVL1393 M12, FLAG vectors such as pPolh-FLAG1 or pPolh-MAT 2, or MAT vectors such as pPolh-MAT1, or pPolh-MAT2.


Yeast vectors include, for example, Gateway® pDEST™ 14 vector, Gateway® pDEST™ 15 vector, Gateway® pDEST™ 17 vector, Gateway® pDEST™ 24 vector, Gateway® pYES-DEST52 vector, pBAD-DEST49 Gateway® destination vector, pAO815 Pichia vector, pFLD1 Pichi pastoris vector, pGAPZA, B, & C Pichia pastoris vector, pPIC3.5K Pichia vector, pPIC6 A, B, & C Pichia vector, pPIC9K Pichia vector, pTEF1/Zeo, pYES2 yeast vector, pYES2/CT yeast vector, pYES2/NT A, B, & C yeast vector, or pYES3/CT yeast vector.


Algae vectors include, for example, pChlamy-4 vector or MCS vector.


Mammalian vectors include, for example, transient expression vectors or stable expression vectors. Exemplary mammalian transient expression vectors include p3×FLAG-CMV 8, pFLAG-Myc-CMV 19, pFLAG-Myc-CMV 23, pFLAG-CMV 2, pFLAG-CMV 6a,b,c, pFLAG-CMV 5.1, pFLAG-CMV 5a,b,c, p3×FLAG-CMV 7.1, pFLAG-CMV 20, p3×FLAG-Myc-CMV 24, pCMV-FLAG-MAT1, pCMV-FLAG-MAT2, pBICEP-CMV 3, or pBICEP-CMV 4. Exemplary mammalian stable expression vectors include pFLAG-CMV 3, p3×FLAG-CMV 9, p3×FLAG-CMV 13, pFLAG-Myc-CMV 21, p3×FLAG-Myc-CMV 25, pFLAG-CMV 4, p3×FLAG-CMV 10, p3×FLAG-CMV 14, pFLAG-Myc-CMV 22, p3×FLAG-Myc-CMV 26, pBICEP-CMV 1, or pBICEP-CMV 2.


In some instances, a cell-free system is used for the production of a cysteine-containing polypeptide. In some cases, a cell-free system comprises a mixture of cytoplasmic and/or nuclear components from a cell and is suitable for in vitro nucleic acid synthesis. In some instances, a cell-free system utilizes prokaryotic cell components. In other instances, a cell-free system utilizes eukaryotic cell components. Nucleic acid synthesis is obtained in a cell-free system based on, for example, Drosophila cell, Xenopus egg, or HeLa cells. Exemplary cell-free systems include E. coli S30 Extract system, E. coli T7 S30 system, or PURExpress®.


Methods of Use

In some embodiments, disclosed herein include methods of modulating an immune response in a subject. In some embodiments, disclosed herein is a method of modulating an immune response in a subject, which comprises administering to the subject a therapeutically effective amount of a small molecule fragment of Formula (I):




embedded image


wherein:

    • RM is a reactive moiety selected from a Michael acceptor moiety, a leaving group moiety, or a moiety capable of forming a covalent bond with the thiol group of a cysteine residue; and
    • F is a small molecule fragment moiety.


In some embodiments, the small molecule fragment interacts with an endogenous cysteine-containing polypeptide expressed in the subject to form a cysteine-containing polypeptide-small molecule fragment adduct. In some instances, the cysteine-containing polypeptide-small molecule fragment adduct comprises a covalent bonding. In some cases, the cysteine-containing polypeptide-small molecule fragment adduct comprises an irreversible bonding. In other cases, the cysteine-containing polypeptide-small molecule fragment adduct comprises a reversible bonding. In some instances, an endogenous cysteine-containing polypeptide is a polypeptide that is expressed or present in a cell of interest (e.g., a diseased cell such as a cancerous cell). In some instances, an endogenous cysteine-containing polypeptide is a polypeptide that is overexpressed in a cell of interest (e.g., a diseased cell such as a cancerous cell). In some instances, an endogenous cysteine-containing polypeptide is a polypeptide that harbors one or more mutations in a cell of interest (e.g., a diseased cell such as a cancerous cell). In some instances, a mutation comprises a missense mutation, an insertion, or a deletion. In some instances, a mutation comprises a truncation, for example, a truncation at the N-terminus or the C-terminus of the polypeptide. In additional instances, an endogenous cysteine-containing polypeptide is a polypeptide that has an altered conformation in a cell of interest (e.g., a diseased cell such as a cancerous cell) relative to the conformation of the wild-type polypeptide.


In some instances, a cysteine-containing polypeptide-small molecule fragment adduct induces an immune response. In some cases, the immune response is a humoral immune response. In other cases, the immune response is a cell-mediated immune response. In some instances, the cysteine-containing polypeptide-small molecule fragment adduct induces a humoral immune response. In some instances, a cysteine-containing polypeptide-small molecule fragment adduct induces a cell-mediated immune response. In additional instances, a cysteine-containing polypeptide-small molecule fragment adduct induces a humoral immune response and a cell-mediated immune response. In some instances, humoral immunity (or antibody-mediated beta cellularis immune system) is the production of antibody and its accessory processes such as Th2 activation, cytokine production, germinal center formation, isotype switching, affinity maturation, and memory cell generation. In some instances, humoral immunity is mediated by macromolecules in the extracellular fluids. In some cases, cell-mediated immunity comprises activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and release of cytokines in response to an antigen. In some cases, cell-mediated immunity differs from humoral immunity in that it does not involve production of antibody.


In some embodiments, a cysteine-containing polypeptide-small molecule fragment adduct increases an immune response relative to a control. In some cases, a cysteine-containing polypeptide-small molecule fragment adduct increases a humoral immune response relative to a control. In additional cases, a cysteine-containing polypeptide-small molecule fragment adduct increases a cell-mediated immune response relative to a control. In additional cases, a cysteine-containing polypeptide-small molecule fragment adduct increases a humoral immune response and a cell-mediated immune response relative to a control.


In some cases, a control is the level of an immune response in the subject prior to administration of the small molecule fragment or is the level of an immune response in a subject who has not been exposed to the small molecule fragment. In some cases, a control is the level of a humoral immune response or a cell-mediated immune response in the subject prior to administration of the small molecule fragment or is the level of a humoral immune response or a cell-mediated immune response in a subject who has not been exposed to the small molecule fragment.


In some instances, a cysteine-containing polypeptide-small molecule fragment adduct modulates an immune response. In some cases, the immune response is a humoral immune response. In other cases, the immune response is a cell-mediated immune response. In some instances, the cysteine-containing polypeptide-small molecule fragment adduct modulates a humoral immune response. In some instances, a cysteine-containing polypeptide-small molecule fragment adduct modulates a cell-mediated immune response. In additional instances, a cysteine-containing polypeptide-small molecule fragment adduct modulates a humoral immune response and a cell-mediated immune response.


In some instances, a cysteine-containing polypeptide is a non-denatured form of the polypeptide.


In some instances, a cysteine-containing polypeptide comprises a biologically active cysteine site. As described above and elsewhere herein, in some cases, a biologically active cysteine site is a cysteine residue that is located about 10 Å or less to an active-site ligand or residue. In other cases, a biologically active cysteine site is a cysteine residue that is located greater than 10 Å from an active-site ligand or residue. In some cases, the cysteine residue that is located greater than 10 Å from the active-site ligand or residue is a non-active site cysteine.


Further as described elsewhere herein, a cysteine-containing polypeptide comprises, in some instances, an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, a plasma protein, transcription related protein, translation related protein, mitochondrial protein, or cytoskeleton related protein. In some cases, the cysteine-containing polypeptide comprises an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, transcription related protein, or translation related protein.


In some embodiments, a cysteine-containing polypeptide is about 20, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 150, 200, 250, 300, 350, 400, 450, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1500, 2000, 2100, 2200, 2500 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 20 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 60 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 70 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 80 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 90 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 100 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 150 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 200 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 300 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 400 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 500 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 800 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 1000 amino acid residues in length or more. In some cases, a cysteine-containing polypeptide is about 1500 amino acid residues in length or more.


In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Tables 1-5. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 1. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 2. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 3. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 4. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 5. In some instances, the cysteine residue of interest is denoted by a (*) in Tables 1-5.


In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Tables 6A-6E. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 6A. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 6B. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 6C. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 6D. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 6E.


In some embodiments, as described above, a small molecule fragment comprises a Michael acceptor moiety which comprises an alkene or an alkyne moiety. In some instances, a covalent bond is formed between a portion of the Michael acceptor moiety on the small molecule fragment and a portion of a cysteine residue of the cysteine-containing polypeptide.


In some instances, a small molecule fragment comprises a small molecule fragment moiety F which is obtained from a compound library. In some instances, the compound library comprises ChemBridge fragment library, Pyramid Platform Fragment-Based Drug Discovery, Maybridge fragment library, FRGx from AnalytiCon, TCI-Frag from AnCoreX, Bio Building Blocks from ASINEX, BioFocus 3D from Charles River, Fragments of Life (FOL) from Emerald Bio, Enamine Fragment Library, IOTA Diverse 1500, BIONET fragments library, Life Chemicals Fragments Collection, OTAVA fragment library, Prestwick fragment library, Selcia fragment library, TimTec fragment-based library, Allium from Vitas-M Laboratory, or Zenobia fragment library. In some cases, F is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B). In some cases, the small molecule fragment is a small molecule fragment illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some instances, a small molecule fragment has a molecular weight of about 150 Dalton or higher. In some cases, a small molecular fragment has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some cases, a molecular weight of the small molecular fragment is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some cases, a small molecular fragment of Formula (I) has a molecular weight of about 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher.


In some instances, the method further comprises administration of a cysteine-containing polypeptide-small molecule fragment adduct. In some instances, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some cases, the cysteine-containing polypeptide-small molecule fragment adduct further enhances or increases an immune response. In some instances, an enhancement or an increase of the immune response is relative to a level of the immune response prior to administration of the cysteine-containing polypeptide-small molecule fragment adduct.


In some embodiments, disclosed herein is a derivative of cereblon protein having the structure of Formula (I),




embedded image




    • wherein,
      • the derivation occurs at cereblon cysteine residue position 188 based on SEQ ID NO: 9665;
      • R is selected from:







embedded image








        • wherein R1 is H, C1-C3 alkyl, or aryl; and





    • F′ is a small molecule fragment moiety.





In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a derivative of cereblon protein having the structure of Formula (I),




embedded image




    • wherein,
      • the derivation occurs at cereblon cysteine residue position 287 based on SEQ ID NO: 9665;
      • R is selected from:







embedded image








        • wherein R1 is H, C1-C3 alkyl, or aryl; and





    • F′ is a small molecule fragment moiety.





In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some cases, the method further comprises administration of an adjuvant.


In some cases, the small molecule fragment is formulated for parenteral, oral, or intranasal administration.


Diseases or Indications

In some embodiments, disclosed herein include a method of administrating a small molecule fragment to a subject in which the small molecule fragment interacts with an endogenous cysteine-containing polypeptide expressed in the subject to form a cysteine-containing polypeptide-small molecule fragment adduct. In some embodiments, the cysteine-containing polypeptide is overexpressed in a disease or condition. In some cases, the overexpressed cysteine-containing polypeptide comprises one or more mutations. In some cases, the cysteine-containing polypeptide comprising one or more mutations is overexpressed in a disease or condition.


In some instances, the disease or condition is cancer. In some cases, the cysteine-containing polypeptide is a cancer-associated protein. In some cases, the cysteine-containing polypeptide is overexpressed in a cancer. In some cases, the cysteine-containing polypeptide comprising one or more mutations is overexpressed in a cancer. In some instances, a mutation comprises a missense mutation, an insertion, or a deletion. In some instances, a mutation comprises a truncation at a terminus of a protein. In some instances, a mutation alters the conformation of a protein relative to the conformation of its wild-type protein. In additional instances, a mutation does not alter the conformation of a protein.


In some instances, a cancer is a solid tumor. In some instances, a cancer is a hematologic malignancy. In some instances, a cancer is a relapsed or refractory cancer, or a metastatic cancer. In some instances, a solid tumor is a relapsed or refractory solid tumor, or a metastatic solid tumor. In some cases, a hematologic malignancy is a relapsed or refractory hematologic malignancy, or a metastatic hematologic malignancy.


In some embodiments, a cancer is a solid tumor. Exemplary solid tumor includes, but is not limited to, anal cancer, appendix cancer, bile duct cancer (i.e., cholangiocarcinoma), bladder cancer, brain tumor, breast cancer, cervical cancer, colon cancer, cancer of Unknown Primary (CUP), esophageal cancer, eye cancer, fallopian tube cancer, gastroenterological cancer, kidney cancer, liver cancer, lung cancer, medulloblastoma, melanoma, oral cancer, ovarian cancer, pancreatic cancer, parathyroid disease, penile cancer, pituitary tumor, prostate cancer, rectal cancer, skin cancer, stomach cancer, testicular cancer, throat cancer, thyroid cancer, uterine cancer, vaginal cancer or vulvar cancer.


In some embodiments, a cysteine-containing polypeptide described herein that is overexpressed and/or comprises one or more mutations is present in a solid tumor. In some cases, a cysteine-containing polypeptide described herein that is overexpressed and/or comprises one or more mutations is present in metastatic solid tumor. In some cases, a cysteine-containing polypeptide described herein that is overexpressed and/or comprises one or more mutations is present in a relapsed or refractory solid tumor. In some instances, a small molecule fragment described herein interacts with a cysteine-containing polypeptide that is present, overexpressed, and/or comprises a mutation in a solid tumor.


In some instances, a cancer is a hematologic malignancy. In some instances, a hematologic malignancy is a leukemia, a lymphoma, a myeloma, a non-Hodgkin's lymphoma, or a Hodgkin's lymphoma. In some instances, a hematologic malignancy comprises chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), high risk CLL, a non-CLL/SLL lymphoma, prolymphocytic leukemia (PLL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), Waldenstrom's macroglobulinemia, multiple myeloma, extranodal marginal zone B cell lymphoma, nodal marginal zone B cell lymphoma, Burkitt's lymphoma, non-Burkitt high grade B cell lymphoma, primary mediastinal B-cell lymphoma (PMBL), immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, B cell prolymphocytic leukemia, lymphoplasmacytic lymphoma, splenic marginal zone lymphoma, plasma cell myeloma, plasmacytoma, mediastinal (thymic) large B cell lymphoma, intravascular large B cell lymphoma, primary effusion lymphoma, or lymphomatoid granulomatosis.


In some embodiments, a cysteine-containing polypeptide described herein that is overexpressed and/or comprises one or more mutations is present in a hematologic malignancy. In some cases, a cysteine-containing polypeptide described herein that is overexpressed and/or comprises one or more mutations is present in metastatic hematologic malignancy. In some cases, a cysteine-containing polypeptide described herein that is overexpressed and/or comprises one or more mutations is present in a relapsed or refractory hematologic malignancy. In some instances, a small molecule fragment described herein interacts with a cysteine-containing polypeptide that is present, overexpressed, and/or comprises a mutation in a hematologic malignancy.


Vaccines

In some embodiments, disclosed herein include vaccines and vaccine formulations that comprises a small molecule fragment described herein, an antibody that recognizes a cysteine-containing polypeptide-small molecule fragment adduct described herein, or a cysteine-containing polypeptide-small molecule fragment adduct described herein. In some embodiments, disclosed herein is a vaccine that comprises a small molecule fragment described herein. In some embodiments, disclosed herein is a vaccine that comprises an antibody that recognizes a cysteine-containing polypeptide-small molecule fragment adduct described herein. In some embodiments, disclosed herein is a vaccine that comprises a cysteine-containing polypeptide-small molecule fragment adduct described herein.


In some instances, a cysteine-containing polypeptide is an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, a plasma protein, transcription related protein, translation related protein, mitochondrial protein, or cytoskeleton related protein. In some cases, the cysteine-containing polypeptide is an enzyme, a transporter, a receptor, a channel protein, an adaptor protein, a chaperone, a signaling protein, transcription related protein, or translation related protein.


In some instances, a cysteine-containing polypeptide comprises a protein illustrated in Tables 1-6. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 1. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 2. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 3. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 4. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 5. In some cases, a cysteine-containing polypeptide comprises a protein illustrated in Table 6 (e.g., Tables 6A-6E).


In some embodiments, a small molecule fragment comprises a Michael acceptor moiety which comprises an alkene or an alkyne moiety. In some instances, a covalent bond is formed between a portion of the Michael acceptor moiety on the small molecule fragment and a portion of a cysteine residue of the cysteine-containing polypeptide.


In some instances, a small molecule fragment comprises a small molecule fragment moiety F which is obtained from a compound library. In some instances, the compound library comprises ChemBridge fragment library, Pyramid Platform Fragment-Based Drug Discovery, Maybridge fragment library, FRGx from AnalytiCon, TCI-Frag from AnCoreX, Bio Building Blocks from ASINEX, BioFocus 3D from Charles River, Fragments of Life (FOL) from Emerald Bio, Enamine Fragment Library, IOTA Diverse 1500, BIONET fragments library, Life Chemicals Fragments Collection, OTAVA fragment library, Prestwick fragment library, Selcia fragment library, TimTec fragment-based library, Allium from Vitas-M Laboratory, or Zenobia fragment library. In some cases, F is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B). In some cases, the small molecule fragment is a small molecule fragment illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some instances, a small molecule fragment has a molecular weight of about 150 Dalton or higher. In some cases, a small molecular fragment has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some cases, the molecular weight of the small molecular fragment is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some cases, the small molecular fragment of Formula (I) has a molecular weight of about 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher.


In some instances, a vaccine is formulated in a conventional manner using one or more physiologically acceptable carriers including excipients and auxiliaries which facilitate processing of the active agents into preparations which are used pharmaceutically. Proper formulation is dependent upon the route of administration chosen. Any of the well-known techniques, carriers, and excipients are used as suitable and as understood in the art.


In some instances, a vaccine is further formulated with a cysteine-containing polypeptide-small molecule fragment adduct. In some instances, a cysteine-containing polypeptide-small molecule fragment adduct enhances an immune response. In some instances, the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine-containing protein having the structure of Formula (I),




embedded image




    • wherein,
      • the derivation occurs at a cysteine residue;
      • R is selected from:







embedded image








        • wherein R1 is H, C1-C3 alkyl, or aryl; and









F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of IDH1 protein having the structure of Formula (I),




embedded image




    • wherein,
      • the derivation occurs at IDH1 cysteine residue position 269 based on SEQ ID NO: 9656;
      • R is selected from:







embedded image








        • wherein R1 is H, C1-C3 alkyl, or aryl; and





    • F′ is a small molecule fragment moiety.





In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of IDH2 protein having the structure of Formula (I),




embedded image


wherein,

    • the derivation occurs at IDH2 cysteine residue position 308 based on SEQ ID NO: 9657;
    • R is selected from:




embedded image






      • wherein R is H, C1-C3 alkyl, or aryl; and







F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of caspase-8 protein having the structure of Formula (I),




embedded image


wherein,

    • the derivation occurs at caspase-8 cysteine residue position 360 based on SEQ ID NO: 9658;
    • R is selected from:




embedded image




    •  wherein R is H, C1-C3 alkyl, or aryl; and





F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of caspase-10 protein having the structure of Formula (I),




embedded image


wherein,

    • the derivation occurs at caspase-10 cysteine residue position 401 based on SEQ ID NO: 9659;
    • R is selected from:




embedded image




    •  wherein R1 is H, C1-C3 alkyl, or aryl; and





F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of PRMT-1 protein having the structure of Formula (I),




embedded image


wherein,

    • the derivation occurs at PRMT-1 cysteine residue position 109 based on SEQ ID NO: 9660;
    • R is selected from:




embedded image






      • wherein R1 is H, C1-C3 alkyl, or aryl; and







F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of ZAK protein having the structure of Formula (I),




embedded image


wherein,

    • the derivation occurs at ZAK cysteine residue position 22 based on SEQ ID NO: 9661;
    • R is selected from:




embedded image






      • wherein R1 is H, C1-C3 alkyl, or aryl; and







F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of IMPDH2 protein having the structure of Formula (I),




embedded image


wherein,

    • the derivation occurs at IMPDH2 cysteine residue position 140 based on SEQ ID NO: 9662;
    • R is selected from:




embedded image






      • wherein R1 is H, C1-C3 alkyl, or aryl; and







F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of IMPDH2 protein having the structure of Formula (I),




embedded image


wherein,

    • the derivation occurs at IMPDH2 cysteine residue position 331 based on SEQ ID NO: 9662;
    • R is selected from:




embedded image






      • wherein R1 is H, C1-C3 alkyl, or aryl; and







F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of TIGAR protein having the structure of Formula (I),




embedded image


wherein,

    • the derivation occurs at TIGAR cysteine residue position 114 based on SEQ ID NO: 9663;
    • R is selected from:




embedded image






      • wherein R1 is H, C1-C3 alkyl, or aryl; and







F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of TIGAR protein having the structure of Formula (I),




embedded image




    • wherein,
      • the derivation occurs at TIGAR cysteine residue position 161 based on SEQ ID NO: 9663;
      • R is selected from:







embedded image








        • wherein R1 is H, C1-C3 alkyl, or aryl; and









F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of PKCθ protein having the structure of Formula (I),




embedded image


wherein,

    • the derivation occurs at PKCθ cysteine residue position 14 based on SEQ ID NO: 9664;
    • R is selected from:




embedded image






      • wherein R1 is H, C1-C3 alkyl, or aryl; and







F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of PKCθ protein having the structure of Formula (I),




embedded image


wherein,

    • the derivation occurs at PKCθ cysteine residue position 17 based on SEQ ID NO: 9664;
    • R is selected from:




embedded image






      • wherein R1 is H, C1-C3 alkyl, or aryl; and







F′ is a small molecule fragment moiety.


In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of cereblon protein having the structure of Formula (I),




embedded image




    • wherein,
      • the derivation occurs at cereblon cysteine residue position 188 based on SEQ ID NO: 9665;
      • R is selected from:







embedded image








        • wherein R1 is H, C1-C3 alkyl, or aryl; and





    • F′ is a small molecule fragment moiety.





In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of cereblon protein having the structure of Formula (I),




embedded image




    • wherein,
      • the derivation occurs at cereblon cysteine residue position 287 based on SEQ ID NO: 9665;
      • R is selected from:







embedded image






      • wherein R1 is H, C1-C3 alkyl, or aryl; and



    • F′ is a small molecule fragment moiety.





In some embodiments, F′ has a molecular weight of about 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 Dalton, or higher. In some embodiments, the molecular weight of F′ is prior to enrichment with a halogen, a nonmetal, or a transition metal. In some embodiments, F′ is a small molecule fragment moiety illustrated in FIG. 1 (e.g., FIG. 1A and/or FIG. 1B).


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XpC*Z, wherein Xp is a polar residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from AIP, PES1, IKBKB, XPO1, KDM4B, NR3C1, GSTP1, TNFAIP3, ACAT1, IRAK1, GNB2L1, IRF4, USP34, ZC3HAV1, USP7, PELI1, DCUN1D1, USP28, UBE2O, RRAGC, MLTK, USP22, KDM3A, and USP16.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XpC*Xn, wherein Xp is a polar residue, C* denotes the site of modification, and Xn is a nonpolar residue. In some cases, the cysteine containing protein is selected from AIP, PES1, IKBKB, XPO1, GSTP1, ACAT1, IRAK1, IRF4, ZC3HAV1, USP7, PELI1, USP28, UBE20, RRAGC, MLTK, USP22, KDM3A, and USP16.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XpC*Xp, wherein Xp is a polar residue and C* denotes the site of modification. In some cases, the cysteine containing protein is selected from KDM4B, NR3C1, TNFAIP3, USP7, and USP22.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XpC*Xb, wherein Xp is a polar residue, C* denotes the site of modification, and Xb is a basic residue. In some cases, the cysteine containing protein is selected from GNB2L1 and USP34.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XpC*Xa, wherein Xp is a polar residue, C* denotes the site of modification, and Xa is an acidic residue. In some cases, the cysteine containing protein is DCUN1D1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif SC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from PES1, IKBKB, GSTP1, ACAT1, IRAK1, ZC3HAV1, and RRAGC.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif NC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from XPO1, GNB2L1, USP34, UBE2O, MLTK, and USP22.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif YC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from KDM4B and NR3C1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif TC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from TNFAIP3, USP7, USP28, KDM3A, and USP16.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif QC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from IRF4, PELI1, DCUN1D1, and USP22.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif CC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is AIP.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XpC*Z, wherein Xp is a polar residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from IKBKB, KDM4B, GSTP1, TNFAIP3, ACAT1, IRAK1, USP34, USP7, PELI1, USP28, UBE2O, MLTK, USP22, KDM3A, and USP16.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XpC*Z, wherein Xp is a polar residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from NR3C1, IRF4, and ZC3HAV1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XpC*Z, wherein Xp is a polar residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from GNB2L1 and RRAGC.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XpC*Z, wherein Xp is a polar residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from AIP, PES1, XPO1, and DCUN1D1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XnC*Z, wherein Xn is a nonpolar residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from PES1, CYR61, UBE2L6, XPO1, ADA, NR3C1, POU2F2, UCHL3, MGMT, ERCC3, ACAT1, STAT3, UBA7, CASP2, IDH2, LRBA, UBE2L3, RELB, IRF8, CASP8, PDIA6, PCK2, PFKFB4, PDE12, USP34, USP48, SMARCC2, and SAMHD1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XnC*Xn, wherein Xn is a nonpolar residue and C* denotes the site of modification. In some cases, the cysteine containing protein is selected from PES1, CYR61, NR3C1, UCHL3, ERCC3, ACAT1, STAT3, CASP2, LRBA, UBE2L3, RELB, PDIA6, PCK2, PFKFB4, USP48, and SMARCC2.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XnC*Xp, wherein Xa is a nonpolar residue, C* denotes the site of modification, and Xp is a polar residue. In some cases, the cysteine containing protein is selected from UBE2L6, POU2F2, MGMT, ACAT1, UBA7, CASP8, PDE12, and USP34.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XnC*Xa, wherein Xn is a nonpolar residue, C* denotes the site of modification, and Xa is an acidic residue. In some cases, the cysteine containing protein is selected from CYR61 and XPO1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XnC*Xb, wherein Xn is a nonpolar residue, C* denotes the site of modification, and Xb is a basic residue. In some cases, the cysteine containing protein is selected from ADA, MGMT, IDH2, IRF8, and SAMHD1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif LC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from PES1, CYR61, XPO1, NR3C1, and SMARCC2.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif PC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from CYR61, UBE2L6, MGMT, ERCC3, ACAT1, and USP48.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif GC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from ADA, RELB, and USP34.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif AC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from UCHL3, CASP2, IDH2, LRBA, CASP8, PCK2, and PDE12.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif VC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from MGMT, ACAT1, UBA7, UBE2L3, and IRF8.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XrC*Z, wherein X, denotes an aromatic residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from POU2F2, PDIA6, and SAMHD1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XaC*Z, wherein Xn is a nonpolar residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from UBE2L6, ADA, UCHL3, MGMT, ERCC3, ACAT1, UBA7, CASP2, IDH2, UBE2L3, CASP8, PDIA6, PCK2, PFKFB4, PDE12, USP34, USP48, and SAMHD1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XnC*Z, wherein Xn is a nonpolar residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from NR3C1, POU2F2, STAT3, RELB, IRF8, and SMARCC2.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XnC*Z, wherein X, is a nonpolar residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from PES1, CYR61, XPO1, and LRBA.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XaC*Z, wherein Xa is an acidic residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from ZAP70, PRKCQ, and PRMT1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif EC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from ZAP70 and PRKCQ.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XbC*Z, wherein Xb is a basic residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from CYR61, ZNF217, NCF1, IREB2, LRBA, CDK5, EP300, EZH2, UBE2S, VCPIP1, RRAGC, and IRAK4.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XbC*Xn, wherein Xb is a basic residue, C* denotes the site of modification, and Xn is a nonpolar residue. In some cases, the cysteine containing protein is selected from CYR61, ZNF217, IREB2, EP300, UBE2S, VCPIP1, RRAGC, and IRAK4.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XbC*Xp, wherein Xb is a basic residue, C* denotes the site of modification, and Xp is a polar residue. In some cases, the cysteine containing protein is selected from NCF1, LRBA, and CDK5.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XbC*Xb, wherein Xb is a basic residue and C* denotes the site of modification. In some cases, the cysteine containing protein is EZH2.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif RC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from ZNF217, NCF1, CDK5, EP300, and IRAK4.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif KC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from CYR61, IREB2, LRBA, and UBE2S.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif HC*Z, wherein C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from EZH2, VCPIP1, and RRAGC.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XbC*Z, wherein Xb is a basic residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from CDK5, EP300, EZH2, UBE2S, VCPIP1, and IRAK4.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XbC*Z, wherein Xb is a basic residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from ZNF217 and IREB2.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XbC*Z, wherein Xb is a basic residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the adapter, scaffolding protein or the modulator protein is selected from NCF1.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XbC*Z, wherein Xb is a basic residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from RRAGC.


In some embodiments, disclosed herein is a vaccine comprising an antibody or its binding fragment thereof that recognizes a derivative of a cysteine containing protein that comprises the motif XbC*Z, wherein Xb is a basic residue, C* denotes the site of modification, and Z is any amino acid. In some cases, the cysteine containing protein is selected from CYR61 and LRBA.


In some cases, a vaccine described herein is further formulated with an adjuvant and/or additional carriers or excipients;


Adjuvant

In some embodiments, the pharmaceutical composition and/or the vaccine further comprises an adjuvant. In some instances, an adjuvant enhances the immune response (humoral and/or cellular) elicited in a subject receiving the pharmaceutical composition and/or the vaccine. In some instances, an adjuvant elicits a Th1-type response. In other instances, an adjuvant elicits a Th2-type response. In some instances, a Th1-type response is characterized by the production of cytokines such as IFN-γ as opposed to a Th2-type response which is characterized by the production of cytokines such as IL-4, IL-5, and IL-10.


In some embodiments, an adjuvant comprises a stimulatory molecule such as a cytokine. Non-limiting examples of cytokines include: CCL20, a-interferon (IFN-a), β-interferon (IFN-β), γ-interferon, platelet derived growth factor (PDGF), TNFa, TNFp, GM-CSF, epidermal growth factor (EGF), cutaneous T cell-attracting chemokine (CTACK), epithelial thymus-expressed chemokine (TECK), mucosae-associated epithelial chemokine (MEC), IL-12, IL-15, IL-28, MHC, CD80, CD86, IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, IL-18, MCP-1, MIP-1a, MIP-1-, IL-8, L-selectin, P-selectin, E-selectin, CD34, GlyCAM-1, MadCAM-1, LFA-1, VLA-1, Mac-1, p150.95, PECAM, ICAM-1, ICAM-2, ICAM-3, CD2, LFA-3, M-CSF, G-CSF, mutant forms of IL-18, CD40, CD40L, vascular growth factor, fibroblast growth factor, IL-7, nerve growth factor, vascular endothelial growth factor, Fas, TNF receptor, Fit, Apo-1, p55, WSL-1, DR3, TRAMP, Apo-3, AIR, LARD, NGRF, DR4, DRS, KILLER, TRAIL-R2, TRICK2, DR6, Caspase ICE, Fos, c-jun, Sp-1, Ap-1, Ap-2, p38, p65Rel, MyD88, IRAK, TRAF6, IkB, Inactive NIK, SAP K, SAP-I, JNK, interferon response genes, NFkB, Bax, TRAIL, TRAILrec, TRAILrecDRC5, TRAIL-R3, TRAIL-R4, RANK, RANK LIGAND, Ox40, Ox40 LIGAND, NKG2D, MICA, MICB, NKG2A, NKG2B, NKG2C, NKG2E, NKG2F, TAPI, and TAP2.


Additional adjuvants include, for example: MCP-1, MIP-1a, MIP-1p, IL-8, RANTES, L-selectin, P-selectin, E-selectin, CD34, GlyCAM-1, MadCAM-1, LFA-1, VLA-1, Mac-1, p150.95, PECAM, ICAM-1, ICAM-2, ICAM-3, CD2, LFA-3, M-CSF, G-CSF, IL-4, mutant forms of IL-18, CD40, CD40L, vascular growth factor, fibroblast growth factor, IL-7, IL-22, nerve growth factor, vascular endothelial growth factor, Fas, TNF receptor, Fit, Apo-1, p55, WSL-1, DR3, TRAMP, Apo-3, AIR, LARD, NGRF, DR4, DR5, KILLER, TRAIL-R2, TRICK2, DR6, Caspase ICE, Fos, c-jun, Sp-1, Ap-1, Ap-2, p38, p65Rel, MyD88, IRAK, TRAF6, IkB, Inactive NIK, SAP K, SAP-1, JNK, interferon response genes, NFkB, Bax, TRAIL, TRAILrec, TRAILrecDRC5, TRAIL-R3, TRAIL-R4, RANK, RANK LIGAND, Ox40, Ox40 LIGAND, NKG2D, MICA, MICB, NKG2A, NKG2B, NKG2C, NKG2E, NKG2F, TAP1, TAP2 and functional fragments thereof.


In some embodiments, an adjuvant is a modulator of a toll like receptor. Examples of modulators of toll-like receptors include TLR-9 agonists and are not limited to small molecule modulators of toll-like receptors such as Imiquimod. Other examples of adjuvants that are used in combination with a vaccine described herein include and are not limited to saponin, CpG ODN, and the like.


Sometimes, an adjuvant is selected from bacteria toxoids, polyoxypropylene-polyoxyethylene block polymers, aluminum salts, liposomes, CpG polymers, oil-in-water emulsions, or a combination thereof.


In some embodiments, an adjuvant is a lipid-based adjuvant, such as MPLA and MDP. In some instances, monophosphoryl lipid A (MPLA) is an adjuvant that causes increased presentation of liposomal antigen to specific T Lymphocytes. In some cases, a muramyl dipeptide (MDP) is used as a suitable adjuvant in conjunction with the vaccine formulations described herein.


In some embodiments, an adjuvant is an oil-in-water emulsion. The oil-in-water emulsion suitable for use with a vaccine described herein include, for example, at least one oil and at least one surfactant, with the oil(s) and surfactant(s) being biodegradable (metabolisable) and biocompatible. In some instances, the oil droplets in the emulsion is less than 5 μm in diameter, or have a sub-micron diameter, with these small sizes being achieved with a high pressure homogenizer to provide stable emulsions. Droplets with a size less than 220 nm are optionally subjected to filter sterilization.


In some instances, oils used include such as those from an animal (such as fish) or vegetable source. Sources for vegetable oils include, for example, nuts, seeds and grains. Peanut oil, soybean oil, coconut oil, and olive oil, exemplify the nut oils. Jojoba oil is used e.g. obtained from the jojoba bean. Seed oils include safflower oil, cottonseed oil, sunflower seed oil, sesame seed oil, etc. The grain group include: corn oil and oils of other cereal grains such as wheat, oats, rye, rice, teff, triticale, and the like. 6-10 carbon fatty acid esters of glycerol and 1,2-propanediol, while not occurring naturally in seed oils, can be prepared by hydrolysis, separation and esterification of the appropriate materials starting from the nut and seed oils. Fats and oils from mammalian milk are optionally metabolizable and are therefore used in with the vaccines described herein. The procedures for separation, purification, saponification and other means necessary for obtaining pure oils from animal sources are well known in the art. Fish contain metabolizable oils which are readily recovered. For example, cod liver oil, shark liver oils, and whale oil such as spermaceti can exemplify several of the fish oils which can be used herein. A number of branched chain oils can be synthesized biochemically in 5-carbon isoprene units and can be generally referred to as terpenoids. Shark liver oil contains a branched, unsaturated terpenoid known as squalene, 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene. Squalane, the saturated analog to squalene, can also be used. Fish oils, including squalene and squalane, can be readily available from commercial sources or can be obtained by methods known in the art.


Other useful oils include tocopherols, for use in elderly patients (e.g. aged 60 years or older) due to vitamin E been reported to have a positive effect on the immune response in this patient group. Further, tocopherols have antioxidant properties that, for example, help to stabilize the emulsions. Various tocopherols exist (α, β, γ, δ, ε or ξ) but α is usually used. An example of α-tocopherol is DL-α-tocopherol. α-tocopherol succinate can be compatible with HIV vaccines and can be a useful preservative as an alternative to mercurial compounds.


Mixtures of oils are used e.g. squalene and α-tocopherol. In some instances, an oil content in the range of 2-20% (by volume) is used.


In some instances, surfactants are classified by their ‘HLB’ (hydrophile/lipophile balance). In some cases, surfactants have a HLB of at least 10, at least 15, and/or at least 16. Surfactants can include, but are not limited to: the polyoxyethylene sorbitan esters surfactants (commonly referred to as the Tweens), especially polysorbate 20 and polysorbate 80; copolymers of ethylene oxide (EO), propylene oxide (PO), and/or butylene oxide (BO), sold under the DOWFAX™ tradename, such as linear EO/PO block copolymers; octoxynols, which can vary in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups, such as octoxynol-9 (Triton X-100, or t-octylphenoxypolyethoxyethanol); (octylphenoxy)polyethoxyethanol (IGEPAL CA-630/NP-40); phospholipids such as phosphatidylcholine (lecithin); nonylphenol ethoxylates, such as the Tergitol™ NP series; polyoxyethylene fatty ethers derived from lauryl, cetyl, stearyl, and oleyl alcohols (known as Brij surfactants), such as triethyleneglycol monolauryl ether (Brij 30); and sorbitan esters (commonly known as the SPANs), such as sorbitan trioleate (Span 85) and sorbitan monolaurate. Non-ionic surfactants can be used herein.


Mixtures of surfactants are used e.g. Tween 80/Span 85 mixtures. A combination of a polyoxyethylene sorbitan ester and an octoxynol are also suitable. Another combination comprises, for example, laureth 9 plus a polyoxyethylene sorbitan ester and/or an octoxynol.


The amounts of surfactants (% by weight) include, for example, polyoxyethylene sorbitan esters (such as Tween 80) 0.01 to 1%, in particular about 0.1%; octyl- or nonylphenoxy polyoxyethanols (such as Triton X-100, or other detergents in the Triton series) 0.001 to 0.1%, such as 0.005 to 0.02%; polyoxyethylene ethers (such as laureth 9) 0.1 to 20%, such as 0.1 to 10% and in particular 0.1 to 1% or about 0.5%.


Carriers and Excipients

In some instances, a vaccine further includes carriers and excipients (including, but not limited to, buffers, carbohydrates, mannitol, proteins, polypeptides or amino acids such as glycine, antioxidants, bacteriostats, chelating agents, suspending agents, thickening agents, and/or preservatives), water, oils (including those of petroleum, animal, vegetable or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil, and the like), saline solutions, aqueous dextrose and glycerol solutions, flavoring agents, coloring agents, detackifiers, and other acceptable additives, adjuvants, binders, or other pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions (such as pH buffering agents, tonicity adjusting agents, emulsifying agents, wetting agents, and the like). Examples of excipients include starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glycerol monostearate, talc, sodium chloride, dried skim milk, glycerol, propylene, glycol, water, ethanol, and the like. In another instances, the pharmaceutical preparation is substantially free of preservatives. In other instances, the pharmaceutical preparation can contain at least one preservative. General methodology on pharmaceutical dosage forms is found in Ansel et al., Pharmaceutical Dosage Forms and Drug Delivery Systems (Lippencott Williams & Wilkins, Baltimore Md. (1999)). It will be recognized that, while any suitable carrier known to those of ordinary skill in the art can be employed to administer the pharmaceutical compositions described herein, the type of carrier will vary depending on the mode of administration.


In some instances, a pharmaceutical composition of the vaccine is encapsulated within liposomes using well-known technology. Biodegradable microspheres can also be employed as carriers for the pharmaceutical compositions described herein. Suitable biodegradable microspheres are disclosed, for example, in U.S. Pat. Nos. 4,897,268; 5,075,109; 5,928,647; 5,811,128; 5,820,883; 5,853,763; 5,814,344 and 5,942,252.


In some cases, a pharmaceutical composition is administered in liposomes or microspheres (or microparticles). Methods for preparing liposomes and microspheres for administration to a patient are well known to those of skill in the art. U.S. Pat. No. 4,789,734, the contents of which are hereby incorporated by reference, describes methods for encapsulating biological materials in liposomes. Essentially, the material is dissolved in an aqueous solution, the appropriate phospholipids and lipids added, along with surfactants if required, and the material dialyzed or sonicated, as necessary. A review of known methods is provided by G. Gregoriadis, Chapter 14, “Liposomes,” Drug Carriers in Biology and Medicine, pp. 2.sup.87-341 (Academic Press, 1979).


Microspheres formed of polymers or proteins are well known to those skilled in the art, and can be tailored for passage through the gastrointestinal tract directly into the blood stream. Alternatively, the compound can be incorporated and the microspheres, or composite of microspheres, implanted for slow release over a period of time ranging from days to months. See, for example, U.S. Pat. Nos. 4,906,474, 4,925,673 and 3,625,214, and Jein, TIPS 19:155-157 (1998), the contents of which are hereby incorporated by reference.


In some cases, a vaccine includes preservatives such as thiomersal or 2-phenoxyethanol. In some instances, the vaccine is substantially free from (e.g. <10 μg/ml) mercurial material e.g. thiomersal-free. In some instances, α-Tocopherol succinate is used as an alternative to mercurial compounds.


For controlling the tonicity, a physiological salt such as sodium salt are optionally included in the vaccine. Other salts include potassium chloride, potassium dihydrogen phosphate, disodium phosphate, and/or magnesium chloride, or the like.


In some instances, a vaccine has an osmolality of between 200 mOsm/kg and 400 mOsm/kg, between 240-360 mOsm/kg, or within the range of 290-310 mOsm/kg.


In some cases, a vaccine comprises one or more buffers, such as a Tris buffer; a borate buffer; a succinate buffer; a histidine buffer (particularly with an aluminum hydroxide adjuvant); or a citrate buffer. Buffers, in some cases, are included in the 5-20 mM range.


In some cases, the pH of the vaccine is between about 5.0 and about 8.5, between about 6.0 and about 8.0, between about 6.5 and about 7.5, or between about 7.0 and about 7.8.


In some instances, a vaccine is sterile. In some cases, the vaccine is non-pyrogenic e.g. containing <1 EU (endotoxin unit, a standard measure) per dose, and can be <0.1 EU per dose.


In some instances, a vaccine includes detergent e.g. a polyoxyethylene sorbitan ester surfactant (known as ‘Tweens’), an octoxynol (such as octoxynol-9 (Triton X-100) or t-octylphenoxypolyethoxyethanol), a cetyl trimethyl ammonium bromide (‘CTAB’), or sodium deoxycholate, particularly for a split or surface antigen vaccine. The detergent can be present only at trace amounts. Thus the vaccine can include less than 1 mg/ml of each of octoxynol-10 and polysorbate 80. Other residual components in trace amounts can be antibiotics (e.g. neomycin, kanamycin, polymyxin B).


In some instances, a vaccine is formulated as a sterile solution or suspension, in suitable vehicles, well known in the art. The pharmaceutical compositions can be sterilized by conventional, well-known sterilization techniques, or can be sterile filtered. The resulting aqueous solutions can be packaged for use as is, or lyophilized, the lyophilized preparation being combined with a sterile solution prior to administration. Suitable formulations and additional carriers are described in Remington “The Science and Practice of Pharmacy” (20th Ed., Lippincott Williams & Wilkins, Baltimore Md.), the teachings of which are incorporated by reference in their entirety herein.


In some instances, a vaccine is formulated with one or more pharmaceutically acceptable salts. Pharmaceutically acceptable salts can include those of the inorganic ions, such as, for example, sodium, potassium, calcium, magnesium ions, and the like. Such salts can include salts with inorganic or organic acids, such as hydrochloric acid, hydrobromic acid, phosphoric acid, nitric acid, sulfuric acid, methanesulfonic acid, p-toluenesulfonic acid, acetic acid, fumaric acid, succinic acid, lactic acid, mandelic acid, malic acid, citric acid, tartaric acid, or maleic acid. In addition, if the agent(s) contain a carboxy group or other acidic group, it can be converted into a pharmaceutically acceptable addition salt with inorganic or organic bases. Examples of suitable bases include sodium hydroxide, potassium hydroxide, ammonia, cyclohexylamine, dicyclohexyl-amine, ethanolamine, diethanolamine, triethanolamine, and the like.


Pharmaceutical compositions comprising an active agent such as small molecule fragment and/or a cysteine-containing polypeptide-small molecule fragment adduct described herein, in combination with one or more adjuvants, can be formulated to comprise certain molar ratios. For example, molar ratios of about 99:1 to about 1:99 of an active agent such as a peptide, a nucleic acid, an antibody or fragments thereof, and/or an APC described herein, in combination with one or more adjuvants, can be used. In some instances, the range of molar ratios of an active agent such as a peptide, a nucleic acid, an antibody or fragments thereof, and/or an APC described herein, in combination with one or more adjuvants, can be selected from about 80:20 to about 20:80; about 75:25 to about 25:75, about 70:30 to about 30:70, about 66:33 to about 33:66, about 60:40 to about 40:60; about 50:50; and about 90:10 to about 10:90. The molar ratio of an active agent such as a peptide, a nucleic acid, an antibody or fragments thereof, and/or an APC described herein, in combination with one or more adjuvants, can be about 1:9, and in some cases can be about 1:1. The active agent such as a peptide, a nucleic acid, an antibody or fragments thereof, and/or an APC described herein, in combination with one or more adjuvants, can be formulated together, in the same dosage unit e.g., in one vial, suppository, tablet, capsule, an aerosol spray; or each agent, form, and/or compound can be formulated in separate units, e.g., two vials, suppositories, tablets, two capsules, a tablet and a vial, an aerosol spray, and the like.


Methods of Generating an Antibody

In some embodiments, a method of generating or raising an antibody or its binding fragment thereof comprises inoculating a mammal (e.g., a mouse, rat, or rabbit) with a small molecule fragment composition described herein. In some instances, the small molecule fragment is a small molecule fragment of Formula (I). In some instances, the method further comprises harvesting and purifying an antibody against the small molecule fragment composition.


In some embodiments, a method of generating or raising an antibody or its binding fragment thereof comprises inoculating a mammal (e.g., a mouse, rat, or rabbit) with a cysteine-containing polypeptide-small molecule fragment adduct described herein. In some instances, the cysteine-containing polypeptide-small molecule fragment adduct is a purified cysteine-containing polypeptide-small molecule fragment adduct. In some instances, the cysteine-containing polypeptide is a polypeptide illustrated in Tables 1-5. In some instances, the cysteine-containing polypeptide an isolated and purified polypeptide comprising at least 70%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, or more sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some instances, the method further comprises harvesting and purifying an antibody against the cysteine-containing polypeptide-small molecule fragment adduct.


In some instances, a method of generating or raising an antibody or its binding fragment thereof comprises inoculating a mammal (e.g., a mouse, rat, or rabbit) with a cultured cell expressing a cysteine-containing polypeptide and further administrating a small molecule fragment described herein to generate a cysteine-containing polypeptide-small molecule fragment adduct. In some instances, the cysteine-containing polypeptide is a polypeptide illustrated in Tables 1-5. In some instances, the cysteine-containing polypeptide is an isolated and purified polypeptide comprising at least 70%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, or more sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some instances, the method further comprises harvesting and purifying an antibody against the cultured cell expressing a cysteine-containing polypeptide and further incubated with a small molecule fragment described herein.


In some instances, a method of generating or raising an antibody or its binding fragment thereof comprises inoculating a mammal (e.g., a mouse, rat, or rabbit) with dendritic-cell derived exosomes. In some instances, a dendritic-cell derived exosome comprises an antigen (e.g., a cysteine-containing polypeptide-small molecule fragment adduct) which then includes activation of the antigen-specific B-cell antibody response. In some cases, the dendritic-cell derived exosome comprises a cysteine-containing polypeptide-small molecule fragment antigen. In some cases, a method of generating or raising an antibody or its binding fragment thereof comprises inoculating a mammal (e.g., a mouse, rat, or rabbit) with dendritic-cell derived exosomes comprising a cysteine-containing polypeptide-small molecule fragment antigen. In some instances, the method further comprises harvesting and purifying an antibody against the dendritic-cell derived exosomes.


Vaccine Formulations

In some embodiments, a vaccine described herein, in combination with one or more adjuvants, is formulated in conventional manner using one or more physiologically acceptable carriers, comprising excipients, diluents, and/or auxiliaries, e.g., which facilitate processing of the active agents into preparations that can be administered. Proper formulation depends at least in part upon the route of administration chosen. The agent(s) described herein can be delivered to a patient using a number of routes or modes of administration, including oral, buccal, topical, rectal, transdermal, transmucosal, subcutaneous, intravenous, and intramuscular applications, as well as by inhalation.


In some instances, the active agents are formulated for parenteral administration (e.g., by injection, for example bolus injection or continuous infusion) and can be presented in unit dose form in ampoules, pre-filled syringes, small volume infusion or in multi-dose containers with an added preservative. The compositions can take such forms as suspensions, solutions, or emulsions in oily or aqueous vehicles, for example solutions in aqueous polyethylene glycol.


For injectable formulations, the vehicle can be chosen from those known in art to be suitable, including aqueous solutions or oil suspensions, or emulsions, with sesame oil, corn oil, cottonseed oil, or peanut oil, as well as elixirs, mannitol, dextrose, or a sterile aqueous solution, and similar pharmaceutical vehicles. The formulation can also comprise polymer compositions which are biocompatible and biodegradable, such as poly(lactic-co-glycolic)acid. These materials can be made into micro or nanospheres, loaded with drug and further coated or derivatized to provide superior sustained-release performance. Vehicles suitable for periocular or intraocular injection include, for example, suspensions of therapeutic agent in injection grade water, liposomes, and vehicles suitable for lipophilic substances. Other vehicles for periocular or intraocular injection are well known in the art.


When administration is by injection, the active agent is sometimes formulated in aqueous solutions, specifically in physiologically compatible buffers such as Hanks' solution, Ringer's solution, or physiological saline buffer. The solution can contain formulatory agents such as suspending, stabilizing and/or dispersing agents. Alternatively, the active compound can be in powder form for constitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use. In another embodiment, the pharmaceutical composition does not comprise an adjuvant or any other substance added to enhance the immune response stimulated by the peptide. In another embodiment, the pharmaceutical composition comprises a substance that inhibits an immune response to the peptide. Methods of formulation are known in the art, for example, as disclosed in Remington's Pharmaceutical Sciences, latest edition, Mack Publishing Co., Easton P.


For oral administration, the active agent is sometimes formulated readily by combining the active agent with pharmaceutically acceptable carriers well known in the art. Such carriers enable the agents of the disclosure to be formulated as tablets, including chewable tablets, pills, dragees, capsules, lozenges, hard candy, liquids, gels, syrups, slurries, powders, suspensions, elixirs, wafers, and the like, for oral ingestion by a patient to be treated. Such formulations can comprise pharmaceutically acceptable carriers including solid diluents or fillers, sterile aqueous media and various non-toxic organic solvents. A solid carrier can be one or more substances which can also act as diluents, flavoring agents, solubilizers, lubricants, suspending agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material. In powders, the carrier generally is a finely divided solid which is a mixture with the finely divided active component. In tablets, the active component generally is mixed with the carrier having the necessary binding capacity in suitable proportions and compacted in the shape and size desired. The powders and tablets preferably contain from about one (1) to about seventy (70) percent of the active compound. Suitable carriers include but are not limited to magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. Generally, the active agents can be included at concentration levels ranging from about 0.5%, about 5%, about 10%, about 20%, or about 30% to about 50%, about 60%, about 70%, about 80% or about 90% by weight of the total composition of oral dosage forms, in an amount sufficient to provide a desired unit of dosage.


In some instances, the vaccine is formulated into aerosol solutions, suspensions, or dry powders. The aerosol can be administered through the respiratory system or nasal passages. For example, one skilled in the art will recognize that a composition of the present disclosure can be suspended or dissolved in an appropriate carrier, e.g., a pharmaceutically acceptable propellant, and administered directly into the lungs using a nasal spray or inhalant. For example, an aerosol formulation comprising a transporter, carrier, or ion channel inhibitor can be dissolved, suspended or emulsified in a propellant or a mixture of solvent and propellant, e.g., for administration as a nasal spray or inhalant. Aerosol formulations can contain any acceptable propellant under pressure, such as a cosmetically or dermatologically or pharmaceutically acceptable propellant, as conventionally used in the art.


An aerosol formulation for nasal administration is generally an aqueous solution designed to be administered to the nasal passages in drops or sprays. Nasal solutions can be similar to nasal secretions in that they are generally isotonic and slightly buffered to maintain a pH of about 5.5 to about 6.5, although pH values outside of this range can additionally be used. Antimicrobial agents or preservatives can also be included in the formulation.


In some instances, an aerosol formulation for inhalations and inhalants are designed so that the agent or combination of agents is carried into the respiratory tree of the subject when administered by the nasal or oral respiratory route. Inhalation solutions can be administered, for example, by a nebulizer. Inhalations or insufflations, comprising finely powdered or liquid drugs, can be delivered to the respiratory system as a pharmaceutical aerosol of a solution or suspension of the agent or combination of agents in a propellant, e.g., to aid in disbursement. Propellants can be liquefied gases, including halocarbons, for example, fluorocarbons such as fluorinated chlorinated hydrocarbons, hydrochlorofluorocarbons, and hydrochlorocarbons, as well as hydrocarbons and hydrocarbon ethers.


Halocarbon propellants can include fluorocarbon propellants in which all hydrogens are replaced with fluorine, chlorofluorocarbon propellants in which all hydrogens are replaced with chlorine and at least one fluorine, hydrogen-containing fluorocarbon propellants, and hydrogen-containing chlorofluorocarbon propellants. Halocarbon propellants are described in Johnson, U.S. Pat. No. 5,376,359, issued Dec. 27, 1994; Byron et al., U.S. Pat. No. 5,190,029, issued Mar. 2, 1993; and Purewal et al., U.S. Pat. No. 5,776,434, issued Jul. 7, 1998. Hydrocarbon propellants useful in the disclosure include, for example, propane, isobutane, n-butane, pentane, isopentane, and neopentane. A blend of hydrocarbons can also be used as a propellant. Ether propellants include, for example, dimethyl ether as well as the ethers. An aerosol formulation in some instances also comprises more than one propellant. For example, the aerosol formulation can comprise more than one propellant from the same class, such as two or more fluorocarbons; or more than one, more than two, more than three propellants from different classes, such as a fluorohydrocarbon and a hydrocarbon. In some instances, vaccines are also dispensed with a compressed gas, e.g., an inert gas such as carbon dioxide, nitrous oxide or nitrogen.


Aerosol formulations can also include other components, for example, ethanol, isopropanol, propylene glycol, as well as surfactants or other components such as oils and detergents. These components can serve to stabilize the formulation and/or lubricate valve components.


In some instances, the aerosol formulation is packaged under pressure and is formulated as an aerosol using solutions, suspensions, emulsions, powders and semisolid preparations. For example, a solution aerosol formulation can comprise a solution of an agent of the disclosure such as a transporter, carrier, or ion channel inhibitor in (substantially) pure propellant or as a mixture of propellant and solvent. The solvent can be used to dissolve the agent and/or retard the evaporation of the propellant. Solvents can include, for example, water, ethanol, and glycols. Any combination of suitable solvents can be used, optionally combined with preservatives, antioxidants, and/or other aerosol components.


In some instances, an aerosol formulation is a dispersion or suspension. A suspension aerosol formulation can comprise a suspension of an agent or combination of agents of the instant disclosure, e.g., a transporter, carrier, or ion channel inhibitor, and a dispersing agent. Dispersing agents can include, for example, sorbitan trioleate, oleyl alcohol, oleic acid, lecithin, and corn oil. A suspension aerosol formulation can also include lubricants, preservatives, antioxidant, and/or other aerosol components.


In some cases, an aerosol formulation is formulated as an emulsion. An emulsion aerosol formulation can include, for example, an alcohol such as ethanol, a surfactant, water, and a propellant, as well as an agent or combination of agents of the disclosure, e.g., a transporter, carrier, or ion channel. The surfactant used can be nonionic, anionic or cationic. One example of an emulsion aerosol formulation comprises, for example, ethanol, surfactant, water, and propellant. Another example of an emulsion aerosol formulation comprises, for example, vegetable oil, glyceryl monostearate and propane.


Vaccine Dosages, Routes of Administration and Therapeutic Regimens

In some instances, a vaccine is delivered via a variety of routes. Exemplary delivery routes include oral (including buccal and sub-lingual), rectal, nasal, topical, transdermal patch, pulmonary, vaginal, suppository, or parenteral (including intramuscular, intraarterial, intrathecal, intradermal, intraperitoneal, subcutaneous, and intravenous) administration or in a form suitable for administration by aerosolization, inhalation or insufflation. General information on drug delivery systems can be found in Ansel et al., Pharmaceutical Dosage Forms and Drug Delivery Systems (Lippencott Williams & Wilkins, Baltimore Md. (1999). The vaccine described herein can be administered to muscle, or can be administered via intradermal or subcutaneous injections, or transdermally, such as by iontophoresis. Epidermal administration of the vaccine can be employed.


In some instances, the vaccine is formulated for administration via the nasal passages. Formulations suitable for nasal administration, wherein the carrier is a solid, can include a coarse powder having a particle size, for example, in the range of about 10 to about 500 microns, which is administered in the manner in which snuff is taken, i.e., by rapid inhalation through the nasal passage from a container of the powder held close up to the nose. The formulation can be a nasal spray, nasal drops, or by aerosol administration by nebulizer. The formulation can include aqueous or oily solutions of the vaccine.


In some cases, the vaccine is a liquid preparation such as a suspension, syrup or elixir. The vaccine can also be a preparation for parenteral, subcutaneous, intradermal, intramuscular, or intravenous administration (e.g., injectable administration), such as a sterile suspension or emulsion.


In some instances, the vaccine includes material for a single immunization, or may include material for multiple immunizations (i.e. a ‘multidose’ kit). The inclusion of a preservative is preferred in multidose arrangements. As an alternative (or in addition) to including a preservative in multidose compositions, the compositions can be contained in a container having an aseptic adaptor for removal of material.


In some instances, the vaccine is administered in a dosage volume of about 0.5 mL, although a half dose (i.e. about 0.25 mL) can be administered to children. Sometimes the vaccine can be administered in a higher dose e.g. about 1 ml.


In some instances, the vaccine is administered as a 1, 2, 3, 4, 5, or more dose-course regimen. Sometimes, the vaccine is administered as a 2, 3, or 4 dose-course regimen. Sometimes the vaccine is administered as a 2 dose-course regimen.


In some instances, the administration of the first dose and second dose of the 2 dose-course regimen are separated by about 0 day, 1 day, 2 days, 5 days, 7 days, 14 days, 21 days, 30 days, 2 months, 4 months, 6 months, 9 months, 1 year, 1.5 years, 2 years, 3 years, 4 years, or more.


In some instances, the vaccine described herein is administered every 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more years. Sometimes, the vaccine described herein is administered every 2, 3, 4, 5, 6, 7, or more years. Sometimes, the vaccine described herein is administered every 4, 5, 6, 7, or more years. Sometimes, the vaccine described herein is administered once.


The dosage examples are not limiting and are only used to exemplify particular dosing regiments for administering a vaccine described herein. The effective amount for use in humans can be determined from animal models. For example, a dose for humans can be formulated to achieve circulating, liver, topical, and/or gastrointestinal concentrations that have been found to be effective in animals. Based on animal data, and other types of similar data, those skilled in the art can determine the effective amounts of a vaccine composition appropriate for humans.


The effective amount when referring to an agent or combination of agents will generally mean the dose ranges, modes of administration, formulations, etc., that have been recommended or approved by any of the various regulatory or advisory organizations in the medical or pharmaceutical arts (e.g., FDA, AMA) or by the manufacturer or supplier.


In some instances, the vaccine is administered before, during, or after the onset of a symptom associated with a disease or condition (e.g., a cancer). Exemplary symptoms can include fever, cough, sore throat, runny and/or stuffy nose, headaches, chills, fatigue, nausea, vomiting, diarrhea, pain, or a combination thereof. In some instances, a vaccine is administered for treatment of a cancer. In some cases, a vaccine is administered for prevention, such as a prophylactic treatment of a cancer. In some cases, a vaccine is administered to illicit an immune response from a patient.


In some aspects, a vaccine and kit described herein are stored at between 2° C. and 8° C. In some instances, a vaccine is not stored frozen. In some instances, a vaccine is stored in temperatures of such as at −20° C. or −80° C. In some instances, a vaccine is stored away from sunlight.


Pharmaceutical Compositions and Formulations

In some embodiments, disclosed herein include pharmaceutical composition and formulations comprising a small molecule fragment of Formula (I). In some instances, also described herein include pharmaceutical composition and formulations comprising a cysteine-containing polypeptide-small molecule fragment adduct. In some instances, the cysteine-containing polypeptide is a polypeptide illustrated in Tables 1-5. In other instances, the cysteine-containing polypeptide is an isolated and purified polypeptide comprising at least 70%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or more sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655. In some embodiments, the pharmaceutical formulations described herein are administered to a subject by multiple administration routes, including but not limited to, parenteral (e.g., intravenous, subcutaneous, intramuscular), oral, intranasal, buccal, rectal, or transdermal administration routes. In some instances, the pharmaceutical composition describe herein is formulated for parenteral (e.g., intravenous, subcutaneous, intramuscular) administration. In other instances, the pharmaceutical composition describe herein is formulated for oral administration. In still other instances, the pharmaceutical composition describe herein is formulated for intranasal administration.


In some embodiments, the pharmaceutical formulations include, but are not limited to, aqueous liquid dispersions, self-emulsifying dispersions, solid solutions, liposomal dispersions, aerosols, solid dosage forms, powders, immediate release formulations, controlled release formulations, fast melt formulations, tablets, capsules, pills, delayed release formulations, extended release formulations, pulsatile release formulations, multiparticulate formulations (e.g., nanoparticle formulations), and mixed immediate and controlled release formulations.


In some embodiments, the pharmaceutical formulations include a carrier or carrier materials selected on the basis of compatibility with the composition disclosed herein, and the release profile properties of the desired dosage form. Exemplary carrier materials include, e.g., binders, suspending agents, disintegration agents, filling agents, surfactants, solubilizers, stabilizers, lubricants, wetting agents, diluents, and the like. Pharmaceutically compatible carrier materials include, but are not limited to, acacia, gelatin, colloidal silicon dioxide, calcium glycerophosphate, calcium lactate, maltodextrin, glycerine, magnesium silicate, polyvinylpyrollidone (PVP), cholesterol, cholesterol esters, sodium caseinate, soy lecithin, taurocholic acid, phosphatidylcholine, sodium chloride, tricalcium phosphate, dipotassium phosphate, cellulose and cellulose conjugates, sugars sodium stearoyl lactylate, carrageenan, monoglyceride, diglyceride, pregelatinized starch, and the like. See, e.g., Remington: The Science and Practice of Pharmacy, Nineteenth Ed (Easton, Pa.: Mack Publishing Company, 1995); Hoover, John E., Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa. 1975; Liberman, H. A. and Lachman, L., Eds., Pharmaceutical Dosage Forms, Marcel Decker, New York, N.Y., 1980; and Pharmaceutical Dosage Forms and Drug Delivery Systems, Seventh Ed. (Lippincott Williams & Wilkins 1999).


In some instances, the pharmaceutical formulations further include pH adjusting agents or buffering agents which include acids such as acetic, boric, citric, lactic, phosphoric and hydrochloric acids; bases such as sodium hydroxide, sodium phosphate, sodium borate, sodium citrate, sodium acetate, sodium lactate and tris-hydroxymethylaminomethane; and buffers such as citrate/dextrose, sodium bicarbonate and ammonium chloride. Such acids, bases and buffers are included in an amount required to maintain pH of the composition in an acceptable range.


In some instances, the pharmaceutical formulation includes one or more salts in an amount required to bring osmolality of the composition into an acceptable range. Such salts include those having sodium, potassium or ammonium cations and chloride, citrate, ascorbate, borate, phosphate, bicarbonate, sulfate, thiosulfate or bisulfite anions; suitable salts include sodium chloride, potassium chloride, sodium thiosulfate, sodium bisulfite and ammonium sulfate.


In some instances, the pharmaceutical formulations further include diluent which are used to stabilize compounds because they can provide a more stable environment. Salts dissolved in buffered solutions (which also can provide pH control or maintenance) are utilized as diluents in the art, including, but not limited to a phosphate buffered saline solution. In certain instances, diluents increase bulk of the composition to facilitate compression or create sufficient bulk for homogenous blend for capsule filling. Such compounds can include e.g., lactose, starch, mannitol, sorbitol, dextrose, microcrystalline cellulose such as Avicel®; dibasic calcium phosphate, dicalcium phosphate dihydrate; tricalcium phosphate, calcium phosphate; anhydrous lactose, spray-dried lactose; pregelatinized starch, compressible sugar, such as Di-Pac® (Amstar); mannitol, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose acetate stearate, sucrose-based diluents, confectioner's sugar; monobasic calcium sulfate monohydrate, calcium sulfate dihydrate; calcium lactate trihydrate, dextrates; hydrolyzed cereal solids, amylose; powdered cellulose, calcium carbonate; glycine, kaolin; mannitol, sodium chloride; inositol, bentonite, and the like.


In some cases, the pharmaceutical formulations include disintegration agents or disintegrants to facilitate the breakup or disintegration of a substance. The term “disintegrate” include both the dissolution and dispersion of the dosage form when contacted with gastrointestinal fluid. Examples of disintegration agents include a starch, e.g., a natural starch such as corn starch or potato starch, a pregelatinized starch such as National 1551 or Amijel®, or sodium starch glycolate such as Promogel® or Explotab®, a cellulose such as a wood product, methylcrystalline cellulose, e.g., Avicel®, Avicel® PH101, Avicel® PH102, Avicel® PH105, Elcema® P100, Emcocel®, Vivacel®, Ming Tia®, and Solka-Floc®, methylcellulose, croscarmellose, or a cross-linked cellulose, such as cross-linked sodium carboxymethylcellulose (Ac-Di-Sol®), cross-linked carboxymethylcellulose, or cross-linked croscarmellose, a cross-linked starch such as sodium starch glycolate, a cross-linked polymer such as crospovidone, a cross-linked polyvinylpyrrolidone, alginate such as alginic acid or a salt of alginic acid such as sodium alginate, a clay such as Veegum® HV (magnesium aluminum silicate), a gum such as agar, guar, locust bean, Karaya, pectin, or tragacanth, sodium starch glycolate, bentonite, a natural sponge, a surfactant, a resin such as a cation-exchange resin, citrus pulp, sodium lauryl sulfate, sodium lauryl sulfate in combination starch, and the like.


In some instances, the pharmaceutical formulations include filling agents such as lactose, calcium carbonate, calcium phosphate, dibasic calcium phosphate, calcium sulfate, microcrystalline cellulose, cellulose powder, dextrose, dextrates, dextran, starches, pregelatinized starch, sucrose, xylitol, lactitol, mannitol, sorbitol, sodium chloride, polyethylene glycol, and the like.


Lubricants and glidants are also optionally included in the pharmaceutical formulations described herein for preventing, reducing or inhibiting adhesion or friction of materials. Exemplary lubricants include, e.g., stearic acid, calcium hydroxide, talc, sodium stearyl fumerate, a hydrocarbon such as mineral oil, or hydrogenated vegetable oil such as hydrogenated soybean oil (Sterotex®), higher fatty acids and their alkali-metal and alkaline earth metal salts, such as aluminum, calcium, magnesium, zinc, stearic acid, sodium stearates, glycerol, talc, waxes, Stearowet®, boric acid, sodium benzoate, sodium acetate, sodium chloride, leucine, a polyethylene glycol (e.g., PEG-4000) or a methoxypolyethylene glycol such as Carbowax™, sodium oleate, sodium benzoate, glyceryl behenate, polyethylene glycol, magnesium or sodium lauryl sulfate, colloidal silica such as Syloid™, Cab-O-Sil®, a starch such as corn starch, silicone oil, a surfactant, and the like.


Plasticizers include compounds used to soften the microencapsulation material or film coatings to make them less brittle. Suitable plasticizers include, e.g., polyethylene glycols such as PEG 300, PEG 400, PEG 600, PEG 1450, PEG 3350, and PEG 800, stearic acid, propylene glycol, oleic acid, triethyl cellulose and triacetin. Plasticizers can also function as dispersing agents or wetting agents.


Solubilizers include compounds such as triacetin, triethylcitrate, ethyl oleate, ethyl caprylate, sodium lauryl sulfate, sodium doccusate, vitamin E TPGS, dimethylacetamide, N-methylpyrrolidone, N-hydroxyethylpyrrolidone, polyvinylpyrrolidone, hydroxypropylmethyl cellulose, hydroxypropyl cyclodextrins, ethanol, n-butanol, isopropyl alcohol, cholesterol, bile salts, polyethylene glycol 200-600, glycofurol, transcutol, propylene glycol, and dimethyl isosorbide and the like.


Stabilizers include compounds such as any antioxidation agents, buffers, acids, preservatives and the like.


Suspending agents include compounds such as polyvinylpyrrolidone, e.g., polyvinylpyrrolidone K12, polyvinylpyrrolidone K17, polyvinylpyrrolidone K25, or polyvinylpyrrolidone K30, vinyl pyrrolidone/vinyl acetate copolymer (S630), polyethylene glycol, e.g., the polyethylene glycol can have a molecular weight of about 300 to about 6000, or about 3350 to about 4000, or about 7000 to about 5400, sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, hydroxymethylcellulose acetate stearate, polysorbate-80, hydroxyethylcellulose, sodium alginate, gums, such as, e.g., gum tragacanth and gum acacia, guar gum, xanthans, including xanthan gum, sugars, cellulosics, such as, e.g., sodium carboxymethylcellulose, methylcellulose, sodium carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, polysorbate-80, sodium alginate, polyethoxylated sorbitan monolaurate, polyethoxylated sorbitan monolaurate, povidone and the like.


Surfactants include compounds such as sodium lauryl sulfate, sodium docusate, Tween 60 or 80, triacetin, vitamin E TPGS, sorbitan monooleate, polyoxyethylene sorbitan monooleate, polysorbates, polaxomers, bile salts, glyceryl monostearate, copolymers of ethylene oxide and propylene oxide, e.g., Pluronica (BASF), and the like. Additional surfactants include polyoxyethylene fatty acid glycerides and vegetable oils, e.g., polyoxyethylene (60) hydrogenated castor oil; and polyoxyethylene alkylethers and alkylphenyl ethers, e.g., octoxynol 10, octoxynol 40. Sometimes, surfactants is included to enhance physical stability or for other purposes.


Viscosity enhancing agents include, e.g., methyl cellulose, xanthan gum, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, hydroxypropylmethyl cellulose acetate stearate, hydroxypropylmethyl cellulose phthalate, carbomer, polyvinyl alcohol, alginates, acacia, chitosans, and combinations thereof.


Wetting agents include compounds such as oleic acid, glyceryl monostearate, sorbitan monooleate, sorbitan monolaurate, triethanolamine oleate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monolaurate, sodium docusate, sodium oleate, sodium lauryl sulfate, sodium doccusate, triacetin, Tween 80, vitamin E TPGS, ammonium salts, and the like.


Therapeutic Regimens for a Pharmaceutical Composition

In some embodiments, pharmaceutical compositions described herein are administered for therapeutic applications. In some embodiments, the pharmaceutical composition is administered once per day, twice per day, three times per day or more. The pharmaceutical composition is administered daily, every day, every alternate day, five days a week, once a week, every other week, two weeks per month, three weeks per month, once a month, twice a month, three times per month, or more. The pharmaceutical composition is administered for at least 1 month, 2 months, 3 months, 4 months, 5 months, 6 months, 7 months, 8 months, 9 months, 10 months, 11 months, 12 months, 18 months, 2 years, 3 years, or more.


In the case wherein the patient's status does improve, upon the doctor's discretion the administration of the composition is given continuously; alternatively, the dose of the composition being administered is temporarily reduced or temporarily suspended for a certain length of time (i.e., a “drug holiday”). In some instances, the length of the drug holiday varies between 2 days and 1 year, including by way of example only, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 10 days, 12 days, 15 days, 20 days, 28 days, 35 days, 50 days, 70 days, 100 days, 120 days, 150 days, 180 days, 200 days, 250 days, 280 days, 300 days, 320 days, 350 days, or 365 days. The dose reduction during a drug holiday is from 10%-100%, including, by way of example only, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 100%.


Once improvement of the patient's conditions has occurred, a maintenance dose is administered if necessary. Subsequently, the dosage or the frequency of administration, or both, can be reduced, as a function of the symptoms, to a level at which the improved disease, disorder or condition is retained.


In some embodiments, the amount of a given agent that corresponds to such an amount varies depending upon factors such as the particular compound, the severity of the disease, the identity (e.g., weight) of the subject or host in need of treatment, but nevertheless is routinely determined in a manner known in the art according to the particular circumstances surrounding the case, including, e.g., the specific agent being administered, the route of administration, and the subject or host being treated. In some instances, the desired dose is conveniently presented in a single dose or as divided doses administered simultaneously (or over a short period of time) or at appropriate intervals, for example as two, three, four or more sub-doses per day.


The foregoing ranges are merely suggestive, as the number of variables in regard to an individual treatment regime is large, and considerable excursions from these recommended values are not uncommon. Such dosages are altered depending on a number of variables, not limited to the activity of the compound used, the disease or condition to be treated, the mode of administration, the requirements of the individual subject, the severity of the disease or condition being treated, and the judgment of the practitioner.


In some embodiments, toxicity and therapeutic efficacy of such therapeutic regimens are determined by standard pharmaceutical procedures in cell cultures or experimental animals, including, but not limited to, the determination of the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population). The dose ratio between the toxic and therapeutic effects is the therapeutic index and it is expressed as the ratio between LD50 and ED50. Compounds exhibiting high therapeutic indices are preferred. The data obtained from cell culture assays and animal studies are used in formulating a range of dosage for use in human. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED50 with minimal toxicity. The dosage varies within this range depending upon the dosage form employed and the route of administration utilized.


Kits/Article of Manufacture

Disclosed herein, in certain embodiments, are kits and articles of manufacture for use with one or more methods described herein. Such kits include a carrier, package, or container that is compartmentalized to receive one or more containers such as vials, tubes, and the like, each of the container(s) comprising one of the separate elements to be used in a method described herein. Suitable containers include, for example, bottles, vials, syringes, and test tubes. In one embodiment, the containers are formed from a variety of materials such as glass or plastic.


The articles of manufacture provided herein contain packaging materials. Examples of pharmaceutical packaging materials include, but are not limited to, blister packs, bottles, tubes, bags, containers, bottles, and any packaging material suitable for a selected formulation and intended mode of administration and treatment.


For example, the container(s) include a small molecule fragment disclosed herein or an antibody that recognizes a cysteine-containing polypeptide-small molecule fragment adduct described herein. Such kits optionally include an identifying description or label or instructions relating to its use in the methods described herein.


A kit typically includes labels listing contents and/or instructions for use, and package inserts with instructions for use. A set of instructions will also typically be included.


In one embodiment, a label is on or associated with the container. In one embodiment, a label is on a container when letters, numbers or other characters forming the label are attached, molded or etched into the container itself; a label is associated with a container when it is present within a receptacle or carrier that also holds the container, e.g., as a package insert. In one embodiment, a label is used to indicate that the contents are to be used for a specific therapeutic application. The label also indicates directions for use of the contents, such as in the methods described herein.


In certain embodiments, the pharmaceutical compositions are presented in a pack or dispenser device which contains one or more unit dosage forms containing a compound provided herein. The pack, for example, contains metal or plastic foil, such as a blister pack. In one embodiment, the pack or dispenser device is accompanied by instructions for administration. In one embodiment, the pack or dispenser is also accompanied with a notice associated with the container in form prescribed by a governmental agency regulating the manufacture, use, or sale of pharmaceuticals, which notice is reflective of approval by the agency of the form of the drug for human or veterinary administration. Such notice, for example, is the labeling approved by the U.S. Food and Drug Administration for prescription drugs, or the approved product insert. In one embodiment, compositions containing a compound provided herein formulated in a compatible pharmaceutical carrier are also prepared, placed in an appropriate container, and labeled for treatment of an indicated condition.


Certain Terminology

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of skill in the art to which the claimed subject matter belongs. It is to be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of any subject matter claimed. In this application, the use of the singular includes the plural unless specifically stated otherwise. It must be noted that, as used in the specification and the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. In this application, the use of “or” means “and/or” unless stated otherwise. Furthermore, use of the term “including” as well as other forms, such as “include”, “includes,” and “included,” is not limiting.


As used herein, ranges and amounts can be expressed as “about” a particular value or range. About also includes the exact amount. Hence “about 5 μL” means “about 5 μL” and also “5 μL.” Generally, the term “about” includes an amount that would be expected to be within experimental error.


The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described.


As used herein, the terms “individual(s)”, “subject(s)” and “patient(s)” mean any mammal. In some embodiments, the mammal is a human. In some embodiments, the mammal is a non-human. None of the terms require or are limited to situations characterized by the supervision (e.g. constant or intermittent) of a health care worker (e.g. a doctor, a registered nurse, a nurse practitioner, a physician's assistant, an orderly or a hospice worker).


“Antibodies” and “immunoglobulins” (Igs) are glycoproteins having the same structural characteristics. The terms are used synonymously. In some instances, the antigen specificity of the immunoglobulin is known.


The term “antibody” is used in the broadest sense and covers fully assembled antibodies, antibody fragments that can bind antigen (e.g., Fab, F(ab′)2, Fv, single chain antibodies, diabodies, antibody chimeras, hybrid antibodies, bispecific antibodies, humanized antibodies, and the like), and recombinant peptides comprising the forgoing.


The terms “monoclonal antibody” and “mAb” as used herein refer to an antibody obtained from a substantially homogeneous population of antibodies, i.e., the individual antibodies comprising the population are identical except for possible naturally occurring mutations that may be present in minor amounts.


Native antibodies” and “native immunoglobulins” are usually heterotetrameric glycoproteins of about 150,000 daltons, composed of two identical light (L) chains and two identical heavy (H) chains. Each light chain is linked to a heavy chain by one covalent disulfide bond, while the number of disulfide linkages varies among the heavy chains of different immunoglobulin isotypes. Each heavy and light chain also has regularly spaced intrachain disulfide bridges. Each heavy chain has at one end a variable domain (VH) followed by a number of constant domains. Each light chain has a variable domain at one end (VL) and a constant domain at its other end; the constant domain of the light chain is aligned with the first constant domain of the heavy chain, and the light chain variable domain is aligned with the variable domain of the heavy chain. Particular amino acid residues are believed to form an interface between the light and heavy-chain variable domains.


The term “variable” refers to the fact that certain portions of the variable domains differ extensively in sequence among antibodies. Variable regions confer antigen-binding specificity. However, the variability is not evenly distributed throughout the variable domains of antibodies. It is concentrated in three segments called complementarity determining regions (CDRs) or hypervariable regions, both in the light chain and the heavy-chain variable domains. The more highly conserved portions of variable domains are celled in the framework (FR) regions. The variable domains of native heavy and light chains each comprise four FR regions, largely adopting a f-pleated-sheet configuration, connected by three CDRs, which form loops connecting, and in some cases forming part of, the 3-pleated-sheet structure. The CDRs in each chain are held together in close proximity by the FR regions and, with the CDRs from the other chain, contribute to the formation of the antigen-binding site of antibodies (see, Kabat et al. (1991) NIH PubL. No. 91-3242, Vol. I, pages 647-669). The constant domains are not involved directly in binding an antibody to an antigen, but exhibit various effector functions, such as Fc receptor (FcR) binding, participation of the antibody in antibody-dependent cellular toxicity, initiation of complement dependent cytotoxicity, and mast cell degranulation.


The term “hypervariable region,” when used herein, refers to the amino acid residues of an antibody that are responsible for antigen-binding. The hypervariable region comprises, amino acid residues from a “complementarily determining region” or “CDR” (i.e., residues 24-34 (L1), 50-56 (L2), and 89-97 (L3) in the light-chain variable domain and 31-35 (H1), 50-65 (H2), and 95-102 (H3) in the heavy-chain variable domain; Kabat et al. (1991) Sequences of Proteins of Immunological Interest, 5th Ed. Public Health Service, National Institute of Health, Bethesda, Md.) and/or those residues from a “hypervariable loop” (i.e., residues 26-32 (L1), 50-52 (L2), and 91-96 (L3) in the light-chain variable domain and (H1), 53-55 (H2), and 96-101 (13) in the heavy chain variable domain; Clothia and Lesk, (1987) J. Mol. Biol., 196:901-917). “Framework” or “FR” residues are those variable domain residues other than the hypervariable region residues, as herein deemed.


“Antibody fragments” comprise a portion of an intact antibody, preferably the antigen-binding or variable region of the intact antibody. Examples of antibody fragments include Fab, Fab, F(ab′)2, and Fv fragments; diabodies; linear antibodies (Zapata et al. (1995) Protein Eng. 10:1057-1062); single-chain antibody molecules; and multispecific antibodies formed from antibody fragments. Papain digestion of antibodies produces two identical antigen-binding fragments, called “Fab” fragments, each with a single antigen-binding site, and a residual “Fc” fragment, whose name reflects its ability to crystallize readily. Pepsin treatment yields an F(ab′)2 fragment that has two antigen-combining sites and is still capable of cross-linking antigen.


“Fv” is the minimum antibody fragment that contains a complete antigen recognition and binding site. This region consists of a dimer of one heavy- and one light-chain variable domain in tight, non-covalent association. It is in this configuration that the three CDRs of each variable domain interact to define an antigen-binding site on the surface of the VH-VL dimer. Collectively, the six CDRs confer antigen-binding specificity to the antibody. However, even a single variable domain (or half of an Fv comprising only three CDRs specific for an antigen) has the ability to recognize and bind antigen, although at a lower affinity than the entire binding site.


The Fab fragment also contains the constant domain of the light chain and the first constant domain (CH1) of the heavy chain. Fab fragments differ from Fab′ fragments by the addition of a few residues at the carboxy terminus of the heavy chain CH1 domain including one or more cysteines from the antibody hinge region. Fab′-SH is the designation herein for Fab′ in which the cysteine residue(s) of the constant domains bear a free thiol group. Fab′ fragments are produced by reducing the F(ab′)2 fragment's heavy chain disulfide bridge. Other chemical couplings of antibody fragments are also known.


The “light chains” of antibodies (immunoglobulins) from any vertebrate species can be assigned to one of two clearly distinct types, called kappa (κ) and lambda (λ), based on the amino acid sequences of their constant domains.


Depending on the amino acid sequence of the constant domain of their heavy chains, immunoglobulins can be assigned to different classes. There are five major classes of human immunoglobulins: IgA, IgD, IgE, IgG, and IgM, and several of these may be further divided into subclasses (isotypes), e.g., IgG, IgG2, IgG3, IgG4, IgA1, and IgA2. The heavy-chain constant domains that correspond to the different classes of immunoglobulins are called alpha, delta, epsilon, gamma, and mu, respectively. The subunit structures and three-dimensional configurations of different classes of immunoglobulins are well known. Different isotypes have different effector functions. For example, human IgG1 and IgG3 isotypes have ADCC (antibody dependent cell-mediated cytotoxicity) activity.


The term “alkyl” as used herein is a branched or unbranched saturated hydrocarbon group of 1 to 24 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl, t-butyl, n-pentyl, isopentyl, s-pentyl, neopentyl, hexyl, heptyl, octyl, nonyl, decyl, dode cyl, tetradecyl, hexadecyl, eicosyl, tetracosyl, and the like. It is understood that the alkyl group is acyclic. In some instances, the alkyl group is branched or unbranched. In some instances, the alkyl group is also substituted or unsubstituted. For example, the alkyl group is substituted with one or more groups including, but not limited to, alkyl, cycloalkyl, alkoxy, amino, ether, halide, hydroxy, nitro, silyl, sulfo-oxo, or thiol. A “lower alkyl” group is an alkyl group containing from one to six (e.g., from one to four) carbon atoms. In some instances, the term alkyl group is also a C1 alkyl, C1-C2 alkyl, C1-C3 alkyl, C1-C4 alkyl, C1-C5 alkyl, C1-C6 alkyl, C1-C7 alkyl, C1-C8 alkyl, C1-C9 alkyl, C1-C10 alkyl, and the like up to and including a C1-C24 alkyl.


The term “aryl” as used herein is a group that contains any carbon-based aromatic group including, but not limited to, benzene, naphthalene, phenyl, biphenyl, anthracene, and the like. The aryl group can be substituted or unsubstituted. In some instances, the aryl group is substituted with one or more groups including, but not limited to, alkyl, cycloalkyl, alkoxy, alkenyl, cycloalkenyl, alkynyl, cycloalkynyl, aryl, heteroaryl, aldehyde, —NH2, carboxylic acid, ester, ether, halide, hydroxy, ketone, azide, nitro, silyl, sulfo-oxo, or thiol. The term “biaryl” is a specific type of aryl group and is included in the definition of “aryl.” In addition, the aryl group is optionally a single ring structure or comprise multiple ring structures that are either fused ring structures or attached via one or more bridging groups such as a carbon-carbon bond. For example, biaryl refers to two aryl groups that are bound together via a fused ring structure, as in naphthalene, or are attached via one or more carbon-carbon bonds, as in biphenyl.


EXAMPLES

These examples are provided for illustrative purposes only and not to limit the scope of the claims provided herein.


Example 1
General Synthetic Methods

Chemicals and reagents were purchased from a variety of vendors, including Sigma Aldrich, Acros, Fisher, Fluka, Santa Cruz, CombiBlocks, BioBlocks, and Matrix Scientific, and were used without further purification, unless noted otherwise. Anhydrous solvents were obtained as commercially available pre-dried, oxygen-free formulations. Flash chromatography was carried out using 230-400 mesh silica gel. Preparative thin layer chromotography (PTLC) was carried out using glass backed PTLC plates 500-2000 μm thickness (Analtech). All reactions were monitored by thin layer chromatography carried out on 0.25 mm E. Merck silica gel plates (60F-254) and visualized with UV light, or by ninhydrin, ethanolic phosphomolybdic acid, iodine, p-anisaldehyde or potassium permanganate stain. NMR spectra were recorded on Varian INOVA-400, Bruker DRX-600 or Bruker DRX-500 spectrometers in the indicated solvent. Multiplicities are reported with the following abbreviations: s singlet; d doublet; t triplet; q quartet; p pentet; m multiplet; br broad. Chemical shifts were reported in ppm relative to TMS and J values were reported in Hz. Mass spectrometry data were collected on a HP1100 single-quadrupole instrument (ESI; low resolution) or an Agilent ESI-TOF instrument (HRMS).


In some embodiments, General Procedure A was used for the synthesis of one or more of the small molecule fragments and/or cysteine-reactive probes described herein. The amine was dissolved in anhydrous CH2Cl2 (0.2 M) and cooled to 0° C. To this, anhydrous pyridine (1.5 equiv.) was added in one portion, then chloroacetyl chloride (1.5 equiv.) dropwise and the reaction was monitored by TLC until complete disappearance of starting material and conversion to product was detected (typically 1 h). If the reaction did not proceed to completion, additional aliquots of pyridine (0.5 equiv.) and chloroacetyl chloride (0.5 equiv.) were added. The reaction was quenched with H2O (1 mL), diluted with CH2Cl2 (20 mL), and washed twice with saturated NaHCO3 (100 mL). The organic layer was concentrated in vacuo and purified by preparatory thin layer or flash column chromatography to afford the desired product. In some embodiments, General Procedure A1 is similar to General Procedure A except triethylamine (3 equiv.) was used instead of pyridine. In some embodiments, General Procedure A2 is similar to General Procedure A except N-methylmorpholine (3 equiv.) was used instead of pyridine.


In some embodiments, General Procedure B was used for the synthesis of one or more of the small molecule fragments and/or cysteine-reactive probes described herein. The amine was dissolved in anhydrous CH2Cl2 (0.2 M) and cooled to 0° C. To this, triethylamine (TEA, 1.5 equiv.), was added in one portion, then acryloyl chloride (1.5 equiv.) dropwise, and the reaction was monitored by TLC until complete disappearance of starting material and conversion to product was detected (typically 1 h). If the reaction did not proceed to completion, additional aliquots of TEA (0.5 equiv.) and acryloyl chloride (0.5 equiv.) were added. The reaction was quenched with H2O (1 mL), diluted with CH2Cl2 (20 mL), and washed twice with saturated NaHCO3 (100 mL). The organic layer was passed through a plug of silica, after which, the eluant was concentrated in vacuo and purified by preparatory thin layer or flash column chromatography to afford the desired product.


In some embodiments, General Procedure C was used for the synthesis of one or more of the small molecule fragments and/or cysteine-reactive probes described herein. Acryloyl chloride (80.4 μL, 1.0 mmol, 2 equiv.) was dissolved in anhydrous CH2Cl2 (4 mL) and cooled to 0° C. A solution of the amine (0.5 mmol, 1 equiv.) and N-methylmorpholine (0.16 mL, 1.5 mmol, 3 equiv.) in CH2Cl2 (2 mL) was then added dropwise. The reaction was stirred for 1 hr at 0° C. then allowed to warm up to room temperature slowly. After TLC analysis showed disappearance of starting material, or 6 h, whichever was sooner, the reaction was quenched with saturated aqueous NaHCO3 (5 mL) and extracted with CH2Cl2 (3×10 mL). The combined organic layers were dried over anhydrous Na2SO4, concentrated in vacuo, and the residue obtained was purified by preparatory thin layer chromatography to afford the desired product.


Synthesis of Probes and Fragments
Purchased Fragments

The following electrophilic fragments were purchased from the indicated vendors. 2 (Santa Cruz Biotechnology sc-345083), 3 (Key Organics JS-092C), 4 (Sigma Aldrich T142433-10 mg), 6 (Toronto Research Chemicals M320600), 8 (Alfa Aesar H33763), 10 (Santa Cruz Biotechnology sc-345060), 11 (Santa Cruz Biotechnology sc-354895), 12 (Santa Cruz Biotechnology sc-354966), 21 (Santa Cruz Biotechnology, sc-279681), 22 (Sigma Aldrich 699357-5G), 26 (Sigma Aldrich T109959), 27 (Santa Cruz Biotechnology sc-342184), 28 (Santa Cruz Biotechnology sc-335173), 29 (Santa Cruz Biotechnology sc-348978), 30 (Santa Cruz Biotechnology sc-355362), 32 (Santa Cruz Biotechnology sc-354613), 33 (Sigma Aldrich R996505), 34 (Santa Cruz Biotechnology sc-355477), 35 (Santa Cruz Biotechnology sc-328985), 41 (Sigma Aldrich L469769), 42 (Sigma Aldrich R901946), 43 (Santa Cruz Biotechnology sc-307626), 52 (Enamine, EN300-08075), 55 (Santa Cruz Biotechnology sc-354880), 57 (VWR 100268-442), 58 (Enzo Life Sciences ALX-430-142-M005), 62 (WuXi Apptec). Synthesis of isotopically-labeled TEV-tags:




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Isotopically-labeled heavy and light tags were synthesized with minor modifications to the procedure reported in Weerapana et al. Nat Protoc 2:1414-1425 (2007) and Weerapana et al. Nature 468:790-795 (2010). Fmoc-Rink-Amide-MBHA resin (EMD Biosciences; 0.5 M, 830 mg, 0.6 mmol/g loading) was deprotected with 4-methylpiperidine in DMF (50% v/v, 2×5 mL, 1 min). Fmoc-Lys(N3)—OH (Anaspec) (500 mg, 1.26 mmol, 1.26 equiv.) was coupled to the resin overnight at room temperature with DIEA (113 μl) and 2-(6-chloro-1H-benzotriazole-1-yl)-, 1,3,3-tetramethylaminium hexafluorophosphate (HCTU; 1.3 mL of 0.5 M stock in DMF) followed by a second overnight coupling with Fmoc-Lys(N3)—OH (500 mg, 1.26 mmol, 1.26 equiv.), DIEA (113 μl), O-(7-azabenzotriazol-1-yl)-N,N,N′,N-tetramethyluronium hexafluorophosphate (HATU; 1.3 mL of 0.5 M stock in DMF). Unmodified resin was then capped (2×30 min) with Ac2P (400 μL) and DIEA (700 μL) in DMF after which the resin was washed with DMF (2×1 min). Deprotection with 4-methylpiperidine in DMF (50% v/v, 2×5 mL, 1 min) and coupling cycles (4 equiv. Fmoc-protected amino acid (EMD biosciences) in DMF) with HCTU (2 mL, 0.5 M in DMF) and DIEA (347.7 μL) were then repeated for the remaining amino acids. For the heavy TEV-tag, Fmoc-Valine-OH (13C5C15H2115NO4, 13C5, 97-99%, 15N, 97-99%, Cambridge Isotope Laboratories, Inc.) was used. Reactions were monitored by ninhydrin stain and dual couplings were used for all steps that did not go to completion. Biotin (0.24 g, 2 equiv.) was coupled for two days at room temperature with NHS (0.1 g, 2 equiv.), DIC (0.16 g, 2 equiv.) and DIEA (0.175 g, 2 equiv.). The resin was then washed with DMF (5 mL, 2×1 min) followed by 1:1 CH2Cl2:MeOH (5 mL, 2×1 min), dried under a stream of nitrogen and transferred to a round-bottom flask. The peptides were cleaved for 90 minutes from the resin by treatment with 95:2.5:2.5 trifluoroacetic acid: water:triisopropylsilane. The resin was removed by filtration and the remaining solution was triturated with cold ether to provide either the light or heavy TEV-tag as a white solid. HPLC-MS revealed only minor impurities and the compounds were used without further purification. HRMS-ESI (m/z): calculated for C83H128N23O23S [M+H]: (Light-TEV-Tag) 1846.9268; found: 1846.9187; calculated for C7813C5H128N2215NO23S [M+H]: (Heavy-TEV-Tag): 1852.9237; found: 1852.9309.


Synthesis of Probes and Fragments
Synthesis of 1



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N-(hex-5-yn-1-yl)-2-chloroacetamide (SI-1)



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To a solution of 5-hexenylamine (63 mg, 0.65 mmol, 1.0 equiv.) in CH2Cl2 (3.2 mL, 0.2 M) at 0° C. was added N-methylmorpholine (215 μL, 3 equiv.) followed by chloroacetic anhydride portionwise (222 mg, 2 equiv.). The reaction was allowed to come to room temperature and then stirred overnight. The reaction was then diluted with ether (50 mL), washed with 1 M HCl, 1 M NaOH, then brine (20 mL each). The combined organic layers were dried over magnesium sulfate and concentrated to yield chloroacetamide SI-1 (74 mg, 66%). 1H NMR (400 MHz, Chloroform-d) δ 6.79 (s, 1H), 4.09 (d, J=1.1 Hz, 2H), 3.34 (q, J=6.8 Hz, 2H), 2.23 (td, J=6.9, 2.7 Hz, 2H), 1.98 (t, J=2.7 Hz, 1H), 1.75-1.62 (m, 4H), 1.62-1.51 (m, 2H).


N-(hex-5-yn-1-yl)-2-iodoacetamide (1)



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To a solution of chloroacetamide SI-1 (36.1 mg, 0.2 mmol) in acetone (1 mL, 0.2 M) was added sodium iodide (47 mg, 1.5 equiv.) and the reaction was stirred overnight. The next day the reaction was filtered through a plug of silica eluting with 20% ethyl acetate in hexanes, and the filtrate was concentrated to yield a 10:1 mixture of the desired iodoacetamide 1 and starting material. This mixture was re-subjected to the reaction conditions for one further day, at which point complete conversion was observed. The product was purified by silica gel chromatography, utilizing a gradient of 5 to 10 to 15 to 20% ethyl acetate in hexanes to yield the desired product (24 mg, 44%). In some embodiments, the reaction is performed with 2.5 equiv. of sodium iodide, in which case re-subjection is not necessary, and purification by PTLC is accomplished in 30% EtOAc/hexanes as eluent. 1H NMR (500 MHz, Chloroform-d) δ 6.16 (s, 1H), 3.69 (s, 2H), 3.30 (q, J=6.8 Hz, 2H), 2.23 (td, J=6.8, 2.6 Hz, 2H), 1.97 (t, J=2.6 Hz, 1H), 1.75-1.61 (m, 2H), 1.61-1.52 (m, 2H). N-(4-bromophenyl)-N-phenylacrylamide (5)




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The title compound was synthesized according to General Procedure C from 4-bromophenylaniline (18.9 mg, 0.0762 mmol, 1 equiv.). Purification of the crude product by prep. TLC (30% EtOAc/hexanes) provided the title compound as a white solid (12.5 mg, 54%). 1H NMR (500 MHz, Chloroform-d) δ 7.47 (d, J=8.2 Hz, 2H), 7.39 (t, J=7.6 Hz, 2H), 7.32 (d, J=7.4 Hz, 1H), 7.21 (d, J=7.7 Hz, 2H), 7.12 (d, J=8.2 Hz, 2H), 6.48 (d, J=16.7 Hz, 1H), 6.17 (dd, J=16.8, 10.3 Hz, 1H), 5.65 (d, J=10.3 Hz, 1H); HRMS-ESI (m/z) calculated for C15H13BrNO [M+H]: 302.0175; found: 302.0176.


Synthesis of 7



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tert-butyl 4-(phenylamino)piperidine-1-carboxylate (SI-2)



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SI-2 was prepared according to Thoma et al, J. Med. Chem. 47:1939-1955 (2004). 1H NMR (400 MHz, Chloroform-d) δ 7.24-7.12 (m, 2H), 6.75-6.68 (m, 1H), 6.66-6.58 (m, 2H), 3.88-3.81 (m, 1H), 3.44 (tt, J=10.4, 3.9 Hz, 2H), 3.00-2.88 (m, 2H), 2.10-1.99 (m, 2H), 1.48 (bs 9H), 1.41-1.27 (m, 2H).


tert-butyl 4-(2-chloro-N-phenylacetamido)piperidine-1-carboxylate (SI-3)



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To a solution of aniline SI-2 (65 mg, 0.24 mmol) at 0° C. in CH2Cl2 (0.6 mL) was added pyridine (38 μL, 2 equiv.) followed by chloroacetyl chloride (37.4 μL, 2.0 equiv.) in CH2Cl2 (0.6 mL). The resulting solution was allowed to warm to room temperature and stirred overnight. The solution was then quenched with saturated aqueous sodium bicarbonate, extracted with Et2O (3×10 mL). The combined organic layers were dried over magnesium sulfate, filtered and concentrated to give an off-white solid, which was used without further purification (47 mg, 57%). 1H NMR (400 MHz, Chloroform-d) δ 7.47-7.38 (m, 3H), 7.18-7.03 (m, 2H), 4.75-4.63 (m, 1H), 4.07 (s, 2H), 3.68 (s, 2H), 2.76 (s, 2H), 1.84-1.69 (m, 2H), 1.35 (s, 9H), 1.27-1.12 (m, 2H).


N-(1-benzoylpiperidin-4-yl)-2-chloro-N-phenylacetamide (7)



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To neat SI-3 (47 mg, 0.128 mmol) was added trifluoroacetic acid (0.7 mL, final 0.2 M). The resulting solution was concentrated under a stream of nitrogen until no further evaporation was observed, providing the deprotected amine as its trifluoroacetate salt. This viscous gum was then treated with triethylamine in ethyl acetate (10% v/v, 2 mL; solution smokes upon addition). The resulting solution was concentrated to afford the free base, which contained only triethylammonium trifluoroacetate and the free amine by proton NMR. A stock solution was prepared by dissolving the resulting gum in CH2Cl2 (1.2 mL, ˜0.1 M final).


The deprotected amine (0.3 mL of stock solution, 0.0319 mmol) was treated with Hunig's base (17.5 μL, 3 equiv.) and benzoyl chloride (7.6 μL, 2.0 equiv.). This solution was stirred overnight, quenched with saturated aqueous sodium bicarbonate, extracted with Et2O (3×10 mL). The resulting solution was dried over magnesium sulfate, filtered and concentrated. The resulting oil was purified by silica gel chromatography (20% EtOAc/hexanes) to afford chloroacetamide 7 as a white solid (8.6 mg, 75%). 1H NMR (500 MHz, Chloroform-d) δ 7.55 (dd, J=5.5, 3.0 Hz, 3H), 7.50-7.32 (m, 5H), 7.21 (s, 2H), 4.92 (tt, J=12.3, 4.0 Hz, 1H), 4.87 (s, 1H), 3.87 (s, 1H), 3.78 (s, 2H), 3.21 (s, 1H), 2.97-2.90 (m, 1H), 2.01 (s, 1H), 1.90 (s, 1H), 1.45 (s, 1H), 1.36-1.26 (m, 1H); HRMS-ESI (m/z) calculated for C20H22ClN2O2 [M+H]: 357.1364; found: 357.1362.


1-(4-benzylpiperidin-J-yl)-2-chloroethan-1-one (9)



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Following General Procedure A, starting from 4-benzylpiperidine (840 mg, 5.2 mmol, 1 equiv.), the desired compound was obtained after column chromatography as a yellow oil (1 g, 81%). Spectroscopic data matches those reported previously reported in Papadopoulou et al. J. Med. Chem. 55:5554-5565 (2012). 1H NMR (500 MHz, Chloroform-d) δ 7.42-7.14 (m, 5H), 4.61 (d, J=13.4 Hz, 1H), 4.14 (q, J=21.9, 11.5 Hz, 2H), 3.89 (d, J=13.5, 1H), 3.11 (td, J=13.1, 2.7 Hz, 1H), 2.69-2.57 (m, 3H), 1.92-1.75 (m, 3H), 1.40-1.21 (m, 2H); HRMS-ESI (m/z) calculated for C14H19ClNO [M+H]: 252.115; found: 252.115.


N-(2-(1H-indol-3-yl)ethyl)-2-chloroacetamide (13)



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Following General Procedure A, starting from tryptamine (400 mg, 2.5 mmol, 1 equiv.), the desired compound was obtained after column chromatography as a brownish solid (460 mg, 77%). 1H NMR (500 MHz, Chloroform-d) δ 8.55 (s, 1H), 7.70 (d, J=7.9 Hz, 1H), 7.45 (d, J=8.1 Hz, 1H), 7.30 (t, J=7.5 Hz, 1H), 7.23 (t, J=7.4 Hz, 1H), 7.10 (s, 1H), 6.84 (s, 1H), 4.08 (s, 2H), 3.72 (q, J=6.4 Hz, 2H), 3.10 (t, J=6.8 Hz, 2H); HRMS-ESI (m/z) calculated for C12H14ClN2O2 [M+H]: 237.0789; found: 237.0791.


N-(3,5-bis(trifluoromethyl)phenyl)acrylamide (14)



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Following General Procedure B, starting from 3,5-bis(trifluoromethyl)aniline (1.16 g, 5 mmol, 1 equiv.), the desired compound was obtained after column chromatography as a white solid (1.05 g, 74%). 1H NMR (500 MHz, Chloroform-d) δ 8.33 (s, 1H), 8.18 (s, 2H), 7.68 (s, 1H), 6.57 (d, J=17.5 Hz, 1H), 6.38 (dd, J=16.9, 10.3 Hz, 1H), 5.93 (d, J=12.5 Hz, 1H); HRMS-ESI (m/z) calculated for C11H8F6NO2 [M+H]: 284.0505; found: 284.0504.


N-(4-phenoxy-3-(trifluoromethyl)phenyl)-N-(pyridin-3-ylmethyl)acrylamide (15)



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4-phenoxy-3-(trifluoromethyl)aniline (260 mg, 1 mmol, 1 equiv.) (Combi-Blocks) was dissolved in TFA (5 mL). Following the reductive amination protocol reported by Boros et al. J. Org. Chem 74:3587-3590 (2009), the reaction mixture was cooled to 0° C. and to this sodium triacetoxyborohydride (STAB) (270 mg, 1.3 mmol, 1.3 equiv.) was added. 3-pyridinecarboxaldehyde (200 mg, 2 mmol, 2 equiv.) was dissolved in CH2Cl2 (5 mL) and slowly added to the reaction mixture. Upon complete conversion to product, the reaction was diluted with CH2Cl2 (20 mL) and washed with saturated sodium bicarbonate solution (3×20 mL) and the organic layer was dried then concentrated under reduced pressure. Without further purification the crude material was dissolved in anhydrous CH2Cl2 and subjected to General Procedure B. The resulting crude was purified by prep. TLC to give a white solid (31 mg, 10%). 1H NMR (500 MHz, Chloroform-d) δ 8.52 (d, J=3.5 Hz, 1H), 8.39 (s, 1H), 7.68 (d, J=7.8. Hz, 1H), 7.40 (t, J=7.7 Hz, 2H), 7.34 (s, 1H), 7.28-7.18 (m, 2H), 7.07 (d, J=8.2 Hz, 2H), 6.98 (d, J=7.5 Hz, 1H), 6.82 (d, J=8.8 Hz, 1H), 6.46 (d, J=16.8 Hz, 1H), 6.01 (dd, J=16.2, 10.7 Hz, 1H), 5.64 (d, J=10.3 Hz, 1H), 4.96 (s, 2H). HRMS-ESI (m/z) calculated for C22H18F3N2O2 [M+H]: 399.1315; found: 399.1315.


Iodoacetamide-rhodamine (16)



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5-(and-6)-((N-(5-aminopentyl)amino)carbonyl)tetramethylrhodamine (tetramethylrhodamine cadaverine) mixed isomers (60 mg, 0.12 mmol, 1 equiv.) were dissolved in anhydrous DMF (500 μL) with sonication. To this was added DIPEA (60 μL, 0.34 mmol, 3 equiv.) and chloroacetyl chloride (10 μL, 0.13 mmol, 1 equiv., diluted 1:10 in DMF) and the reaction was stirred at room temperature for 20 min until complete conversion to the product was detected by TLC. The DMF was removed under a stream of nitrogen and the reaction mixture was separated by PTLC in MeOH:CH2Cl2:TEA (15:85:0.001). The chloroacetamide rhodamine was then eluted in MeOH:CH2Cl2 (15:85), concentrated under reduced pressure and redissolved in acetone (500 μL). NaI (150 mg, 1 mmol, 10 equiv.) was added to this and the reaction was stirred for 20 min at 50° C. until complete conversion to product was detected and the crude reaction mixture was purified by reverse phase HPLC on a C18 column and concentrated to yield the title compound as a purple solid that is a mixture of 5 and 6 carboxamide tetramethylrhodamine isomers (ratio˜6:1) (10 mg, 12%). 1H NMR (600 MHz, Methanol-d4) δ 8.87 (t, J=4.8 Hz, 0.14H), 8.80-8.71 (m, 1H), 8.41 (dd, J=8.2, 1.1 Hz, 0.86H), 8.35 (br s, 1H), 8.27 (dt, J=7.9, 1.5 Hz, 0.164H), 8.20 (dt, J=8.2, 1.5 Hz, 0.86H), 7.81 (s, 0.86H), 7.53 (d, J=7.8 Hz, 0.14H), 7.18-7.11 (m, 2H), 7.07 (d, J=9.5 Hz, 2H), 7.00 (s, 2H), 3.68-3.62 (m, 2H), 3.46-3.37 (m, 2H), 3.31 (s, 12H, obscured by solvent) 3.21-3.12 (m, 2H), 1.81-1.21 (m, 6H); HRMS-ESI (m/z) calculated for C32H36N405 [M+H]: 683.1725; found: 683.1716.


N-(3,5-bis(trifluoromethyl)phenyl)acetamide (17)



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Following General Procedure A, starting with 3,5-bis(trifluoromethyl)aniline (327 mg, 1.42 mmol, 1 equiv.) and acetic anhydride (200 μL, 3 mmol, 2 equiv.), the title compound was obtained after PTLC as a white solid (302 mg, 78%). 1H NMR (500 MHz, Chloroform-d) δ 8.10 (s, 2H), 7.72 (s, 1H), 7.68 (s, 1H), 2.32 (d, J=0.9 Hz, 3H). HRMS-ESI (m/z) calculated for C11H8F6NO2 [M+H]: 284.0505; found: 284.0504.


Synthesis of 18 and 19



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3-amino-N-(hex-5-yn-1-yl)-5-(trifluoromethyl)benzamide (SI-5)



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To a solution of 3-amino-5-(trifluoromethyl)benzoic acid (74 mg, 0.36 mmol) in acetonitrile (3.6 mL, 0.1 M final) was added EDCI (83 mg, 1.2 equiv.) followed by hex-5-ynamine (35 mg, 1.0 equiv.) followed by 1-hydroxybenzotriazole hydrate (HOBt, 66.3 mg, 1.2 equiv.) and the resulting solution was stirred overnight. The reaction was diluted with ethyl acetate, washed with 1 M HCl twice and then brine. The organic layer was dried over magnesium sulfate and concentrated to yield aniline SI-5 (97.4 mg, 95%) as a white solid. 1H NMR (400 MHz, Chloroform-d) δ 7.29-7.22 (m, 2H), 6.98 (t, J=1.8 Hz, 1H), 6.38 (t, J=5.5 Hz, 1H), 4.08 (s, 2H), 3.46 (td, J=7.1, 5.7 Hz, 2H), 2.25 (td, J=6.9, 2.6 Hz, 2H), 1.99 (t, J=2.7 Hz, 1H), 1.81-1.55 (m, 4H).


3-acrylamido-N-(hex-5-yn-1-yl)-5-(trifluoromethyl)benzamide (18)



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Following General Procedure B, starting with SI-5 (42 mg, 0.15 mmol, 1 equiv.), the title compound was obtained after column chromatography as a white solid (34 mg, 70%). 1H NMR (500 MHz, Chloroform-d) δ 8.94 (s, 1H), 8.24 (d, J=11.9 Hz, 2H), 7.71 (s, 1H), 6.87 (t, J=5.7 Hz, 1H), 6.55 (dd, J=17.4, 0.7 Hz, 1H), 6.43 (dd, J=16.9, 10.1 Hz, 1H), 5.88 (dd, J=10.1, 1.3 Hz, 1H), 3.56 (q, J=6.7 Hz, 2H), 2.33 (td, J=6.9, 2.7 Hz, 2H), 2.06 (t, J=2.7 Hz, 1H), 1.87 (p, J=7.3 Hz, 2H), 1.69 (p, J=7.8 Hz, 2H); HRMS-ESI (m/z) calculated for C17H18F3N2O2 [M+H]: 339.1314; found 339.1313.


3-acrylamido-N-(hex-5-yn-1-y)-5-(trifluoromethyl)benzamide (19)



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Synthesized according to General Procedure A2, starting from SI-5. 1H NMR (600 MHz, Chloroform-d) δ 8.57 (s, 1H), 8.16 (t, J=1.8 Hz, 1H), 8.05 (t, J=1.8 Hz, 1H), 7.79 (d, J=2.0 Hz, 1H), 6.38 (d, J=6.1 Hz, 1H), 4.23 (s, 2H), 3.51 (td, J=7.1, 5.7 Hz, 2H), 2.27 (td, J=6.9, 2.7 Hz, 2H), 2.00 (t, J=2.6 Hz, 1H), 1.82-1.74 (m, 2H), 1.71-1.59 (m, 2H); HRMS-ESI (m/z) calculated for C16H17ClF3N2O2 [M+H]: 361.0925; found: 361.0925.


2-chloro-1-(4-(hydroxydiphenylmethyl)piperidin-1-yl)ethan-1-one (20)



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Following General Procedure A, starting with α,α-diphenyl-4-piperidinemethanol (800 mg, 3 mmol, 1 equiv.), the title compound was obtained after column chromatography as a white solid (637 mg, 61%). 1H NMR (500 MHz, Chloroform-d) δ 7.56 (d, J=7.6 Hz, 4H), 7.39 (q, J=7.1 Hz, 4H), 7.28 (q, J=6.8 Hz, 2H), 4.66 (d, J=13.3 Hz, 1H), 4.07 (dd, J=12.2, 4.2 Hz, 2H), 3.91 (d, J=13.4 Hz, 1H), 3.18 (t, J=12.9 Hz, 1H), 2.77-2.62 (m, 3H), 1.67 (t, J=12.5 Hz, 2H), 1.56 (q, J=11.8 Hz, 1H), 1.44 (q, J=12.4, 11.8 Hz, 1H); HRMS-ESI (m/z) calculated for C20H23ClNO2 [M+H]: 344.1412; found: 344.1412.


(E)-3-(3,5-bis(trifluoromethyl)phenyl)-2-cyanoacrylamide (23)



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3,5-bis(trifluoromethyl)benzaldehyde (880 mg, 3.6 mmol, 1 equiv.) and 2-cyanoacetamide (460 mg, 5.5 mmol, 1.5 equiv.) were dissolved in MeOH (10 mL). To this was added piperidine (214 mg, 0.7 equiv.) and the reaction was stirred at room temperature for 30 minutes at which point starting material was consumed. After addition of an equivalent volume of water (10 mL), the precipitate was collected by filtration and washed with water/methanol (1:1) to yield the title compound as a white solid (534 mg, 47%). 1H NMR (400 MHz, Acetone-d6) δ 8.78 (s, 2H), 8.61 (s, 1H), 8.41 (s, 1H), 7.57 (s, 1H), 7.42 (s, 1H); HRMS-ESI (m/z) calculated for C12H7F6N2O2 [M+H]: 309.0457; found: 309.0459.


N-(3,5-bis(trifluoromethyl)phenyl)-2-bromopropanamide (24)



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Following General Procedure A1, starting with 3,5-bis(trifluoromethyl)aniline (250 mg, 1.1 mmol, 1 equiv.) and 2-bromopropionyl chloride (200 j±L, 2 mmol, 1.8 equiv.) the title compound was obtained by PTLC as a white solid (130 mg, 35%). 1H NMR (500 MHz, Chloroform-d) δ 8.34 (s, 1H), 8.06 (s, 2H), 7.66 (s, 1H), 4.58 (q, J=7.0 Hz, 1H), 1.98 (d, J=7.0 Hz, 3H); HRMS-ESI (m/z) calculated for C11H7BrF6NO [M−H]: 361.9621; found: 361.9623.


N-(3,5-bis(trifluoromethyl)phenyl)-2-chloropropanamide (25)



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Following General Procedure A1, starting with 3,5-bis(trifluoromethyl)aniline (327 mg, 1.42 mmol, 1 equiv.) and 2-chloropropionyl chloride (200 μL, 2 mmol, 1.8 equiv.) the title compound was obtained by PTLC as a white solid (250 mg, 55%). 1H NMR (500 MHz, Chloroform-d) δ 8.61 (s, 1H), 8.16 (s, 2H), 7.75 (s, 1H), 4.67 (q, J=7.1 Hz, 1H), 1.93 (d, J=7.1 Hz, 3H). HRMS-ESI (m/z) calculated for C11H7ClF6NO [M−H]: 318.0126; found: 318.0126.


N-(3,5-bis(trifluoromethyl)phenyl)-N-(pyridin-3-ylmethyl)acrylamide (31)



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3,5-bis(trifluoromethyl)aniline (350 mg, 1.6 mmol, 1 equiv.) was dissolved in TFA (5 mL). The reaction mixture was cooled to 0° C. and to this sodium triacetoxyborohydride (STAB) (400 mg, 2 mmol, 1.3 equiv.) was added. 3-pyridinecarboxaldehyde (244 mg, 1.5 mmol, 1 equiv.) was dissolved in CH2Cl2 (5 mL) and slowly added to the reaction mixture dropwise over 10 minutes. Upon complete conversion to product, the reaction mixture was diluted with CH2Cl2 (20 mL) and washed with saturated sodium bicarbonate solution (3×20 mL) and the organic layer was dried then concentrated under reduced pressure. Without further purification the crude material was dissolved in anhydrous CH2Cl2 and subjected to General Procedure B. The resulting crude was purified by PTLC to give a white solid (10 mg, 2%). 1H NMR (500 MHz, Chloroform-d) δ 8.63 (d, J=3.8 Hz, 1H), 8.49 (s, 1H), 7.93 (s, 1H), 7.70 (d, J=7.7 Hz, 1H), 7.55 (s, 2H), 7.35 (dd, J=7.6, 5.3 Hz, 1H), 6.60 (dd, J=16.6, 1.6 Hz, 1H), 6.02 (dd, J=16.9, 10.2 Hz, 1H), 5.79 (dd, J=10.3, 1.6 Hz, 1H), 5.11 (s, 2H). HRMS-ESI (m/z) calculated for C17H13F6N2O [M+H]: 375.0927; found: 375.0928.


3-(2-chloroacetamido)-5-(trifluoromethyl)benzoic acid (36)



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To a solution of 3-amino-5-(trifluoromethyl)benzoic acid (500 mg, 2.44 mmol) in 1.5 mL of dimethylacetamide (1.6 M) at 0° C. was added chloroacetyl chloride (214 μL, 2.69 mmol, 1.1 equiv.). The resulting solution was warmed to ambient temperature and stirred for 20 minutes, at which point ethyl acetate (40 mL) and water (30 mL) were added. The pH of the aqueous layer was adjusted to pH 10 via addition of 1 N NaOH, and the phases were separated. The aqueous layer was washed with 40 mL of ethyl acetate, then acidified by adding 1 N HCl. The product was extracted with ethyl acetate (40 mL), and the organic layer was washed with 1M HCl (2×40 mL), brine (40 mL), dried over magnesium sulfate and concentrated to provide the desired product (456 mg, 66%). 1H NMR (500 MHz, Chloroform-d) δ 8.31 (s, 1H), 8.27 (s, 1H), 8.14 (s, 1H), 4.13 (s, 2H); HRMS-ESI (m/z) calculated for C10H8ClF3NO3 [M+H]: 282.0139; found: 282.0141.


1-(4-(5-fluorobenzisoxazol-3-yl)piperidin-1-yl)prop-2-en-1-one (37)



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The title compound was obtained starting from 6-fluoro-3(4-piperidinyl)-1,2-benzisoxazole hydrochloride (53 mg, 0.2 mmol, 1 equiv.) according to General Procedure C as a colorless oil (49.1 mg, 87%). 1H NMR (400 MHz, Chloroform-d) δ 7.64 (dd, J=8.7, 5.1 Hz, 1H), 7.27 (dd, J=8.4, 2.3 Hz, 1H), 7.08 (td, J=8.9, 2.1 Hz, 1H), 6.64 (dd, J=16.8, 10.6 Hz, 1H), 6.32 (dd, J=16.9, 1.9 Hz, 11H), 5.73 (dd, J=10.6, 1.9 Hz, 1H), 4.70 (d, J=13.4 Hz, 1H), 4.15 (d, J=12.4 Hz, 1H), 3.53-3.13 (m, 2H), 2.99 (t, J=13.1 Hz, 1H), 2.25-2.07 (m, 2H), 2.00 (ddd, J=23.1, 14.2, 7.8 Hz, 211); HRMS-ESI (m/z) calculated for C15H16FN2O [M+H]: 275.119; found: 275.119.


tert-butyl 4-(4-acrylamido-2,6-difluorophenyl)piperazine-1-carboxylate (38)



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The title compound was obtained starting from tert-Butyl 4-(4-amino-2,6-difluorophenyl)piperazine-1-carboxylate according to General Procedure B. 1H NMR (400 MHz, Chloroform-d) δ 8.12 (s, 1H), 7.13 (d, J=10.4 Hz, 2H), 6.36 (d, J=16.9 Hz, 1H), 6.19 (dd, J=16.8, 10.2 Hz, 1H), 5.70 (d, J=10.2 Hz, 1H), 3.45 (t, J=4.7 Hz, 4H), 3.00 (t, J=3.7 Hz, 4H), 1.41 (s, 9H); HRMS-ESI (m/z) calculated for C18H24F2N3O3 [M+H]: 368.178; found: 368.178.


N-(4-bromo-2,5-dimethylphenyl)acrylamide (40)



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Following General Procedure B, starting from 4-bromo-2,5-dimethylaniline (900 mg, 4.5 mmol, 1 equiv.), the title compound was obtained after column chromatography and recrystallization from cold CH2Cl2 as a white solid (611 mg, 40%). 1H NMR (500 MHz, Chloroform-d) δ 7.87 (s, 1H), 7.43 (s, 1H), 7.16 (s, 1H), 6.50 (d, J=16.7 Hz, 1H), 6.35 (dd, J=16.4, 10.3 Hz, 1H), 5.86 (d, J=10.3 Hz, 1H), 2.42 (s, 3H), 2.28 (s, 3H); HRMS-ESI (m/z) calculated for C11H13BrNO [M+H]: 254.0175; found: 254.0175.


2-Chloroacetamido-2-deoxy-α/β-D-glucopyranose (44)



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To a stirred solution of hexosamine hydrochloride (590 mg, 3.39 mmol, 1 equiv.) in anhydrous MeOH (200 mL) at room temperature was added sodium metal (60 mg, 2.6 mmol, 0.78 equiv.), TEA (400 μL, 5.7 mmol, 1.8 equiv.). Chloroacetic anhydride (1 g, 5.9 mmol, 1 equiv.) was then added and the mixture stirred for 6 h, monitoring for completeness by TLC. After which, the reaction mixture was concentrated in vacuo. The crude product then was purified by two rounds of column chromatography to afford the pure title product as a white solid (610 mg, 72%). 1H NMR (500 MHz, Methanol-d4) δ 5.20 (d, J=3.7 Hz, 1Hα), 4.75 (d, J=8.3 Hz, 1H3), 4.19 (dd, J=20.2, 13.9 Hz, 2H), 4.19 (d, J=12.6 Hz, 1H), 3.95 (dd, J=10.6, 3.5 Hz, 1Hα), 3.83 (m, 3Hα, 3HP), 3.74 (d, J=5.1 Hz, 1Hβ), 3.70 (dd, J=11.4, 8.9 Hz, 1Hβ), 3.60 (dd, J=10.7, 9.5 Hz, 1Hβ), 3.46 (t, J=9.3 Hz, 1H), 3.42 (t, J=10.0 Hz, 1H); HRMS-ESI (m/z) calculated for C8H15ClNO6 [M+H]: 256.0582; found: 256.0582.


2-chloro-1-(2-methyl-3,4-dihydroquinolin-1 (2H)-yl)ethan-1-one (45)



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Chloroacetyl chloride (80.4 μL, 0.9 mmol, 1.7 equiv.) was dissolved in anhydrous CH2Cl2 (3 mL) and cooled to 0° C. A solution of 2-methyl-1,2,3,4-tetrahydroquinoline (80.1 mg, 0.544 mmol, 1 equiv.) and N-methylmorpholine (0.11 mL, 1.0 mmol, 1.8 equiv.) in CH2Cl2 (2 mL) was then added dropwise. After 6 h, the reaction was quenched with saturated aqueous NaHCO3 (5 mL) and extracted with CH2Cl2 (3×10 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The resultant residue was purified by prep. TLC (30% EtOAc/hexanes), providing the title compound as an off-white solid (108.8 mg, 89%). 1H NMR (400 MHz, chloroform-d) δ 7.30-7.13 (m, 4H), 4.86-4.75 (m, 1H), 4.20 (d, J=12.5 Hz, 1H), 4.09 (d, J=12.5 Hz, 1H), 2.69-2.58 (m, 1H), 2.59-2.46 (m, 1H), 2.46-2.31 (m, 1H), 1.36-1.29 (m, 1H), 1.15 (d, J=6.5 Hz, 3H); HRMS-ESI (m/z) calculated for C2H15ClNO [M+H]: 224.0837; found: 224.0836.


N-cyclohexyl-N-phenylacrylamide (46)



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The title compound was synthesized according to General Procedure C from N-cyclohexylaniline (89.5 mg, 0.511 mmol, 1 equiv.). Purification of the crude product by flash column chromatography (10-20% EtOAc/hexanes) then prep. TLC (30% EtOAc/hexanes) provided the title compound as an off-white solid (53.1 mg, 45%). 1H NMR (400 MHz, chloroform-d) δ 7.42-7.33 (m, 3H), 7.10-7.06 (m, 2H), 6.31 (dd, J=16.7, 2.1 Hz, 1H), 5.77 (dd, J=16.7, 10.3 Hz, 1H), 5.41 (dd, J=10.4, 2.1 Hz, 1H), 4.65 (tt, J=12.2, 3.7 Hz, 1H), 1.85 (dt, J=11.2, 1.8 Hz, 2H), 1.75-1.68 (m, 2H), 1.61-1.53 (m, 1H), 1.40 (qt, J=13.3, 3.6 Hz, 2H), 1.07 (qd, J=12.4, 3.6 Hz, 2H), 0.91 (qt, J=13.1, 3.8 Hz, 1H); HRMS-ESI (m/z) calculated for C15H20NO [M+H]: 230.1539; found: 230.1539.


1-(5-bromoindolin-1-yl)prop-2-en-1-one (47)



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The title compound was synthesized according to General Procedure C from 5-bromoindoline (41.7 mg, 0.211 mmol, 1 equiv.), acryloyl chloride (32 μL, 0.40 mmol, 1.9 equiv.), and changing the base to pyridine (32 μL, 0.40 mmol, 1.9 equiv.). Purification of the crude product by re-precipitation from EtOAc provided the title compound as a white solid (67.8 mg, 64%). 1H NMR (400 MHz, chloroform-d) δ 8.16 (d, J=8.6 Hz, 1H), 7.33-7.25 (m, 2H), 6.60-6.42 (m, 211), 5.84-5.76 (m, 1H), 4.15 (t, J=8.6 Hz, 2H), 3.17 (t, J=8.6 Hz, 2H); HRMS-ESI (m/z) calculated for C11H11BrNO [M+H]: 252.0018; found: 252.0017.


N-(1-benzylpiperidin-4-yl)-N-phenylacrylamide (48)



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The title compound was synthesized according to General Procedure C from 1-benzyl-N-phenylpiperidin-4-amine (30.0 mg, 0.113 mmol, 1 equiv.), acryloyl chloride (17 μL, 0.21 mmol, 1.9 equiv.), and changing the base to pyridine (17 μL, 0.21 mmol, 1.9 equiv.). Purification of the crude product by prep. TLC provided the title compound as a white solid (22.5 mg, 64%). 1H NMR (400 MHz, chloroform-d) δ 7.62-7.56 (m, 2H), 7.43-7.36 (m, 6H), 7.05 (d, J=6.2 Hz, 2H), 6.29 (dd, J=16.8, 2.1 Hz, 1H), 5.79 (dd, J=16.8, 10.3 Hz, 1H), 5.46 (dd, J=10.3, 2.1 Hz, 1H), 4.81-4.70 (m, 1H), 4.09 (s, 2H), 3.41 (d, J=12.0 Hz, 2H), 2.82 (q, J=11.5 Hz, 2H), 2.21 (q, J=11.9 Hz, 2H), 1.94 (d, J=14.2 Hz, 2H); HRMS-ESI (m/z) calculated for C21H25N2O [M+H]: 321.1961; found: 321.1962.


2-chloro-N-(2-methyl-5-(trifluoromethyl)phenyl)acetamide (49)



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The title compound was synthesized according to General Procedure A1 from 2-methyl-5-(trifluoromethyl)aniline (35.0 mg, 0.2 mmol, 1 equiv.). Purification of the crude product by prep. TLC (20% EtOAc/hexanes) provided the title compound as a white solid (48.2 mg, 95%). 1H NMR (600 MHz, chloroform-d) δ 8.31 (s, 1H), 8.25 (d, J=1.9 Hz, 1H), 7.37 (dd, J=7.9, 1.8 Hz, 1H), 7.32 (d, J=7.9 Hz, 1H), 4.25 (s, 2H1), 2.36 (s, 3H); HRMS-ESI calculated for C10H10ClF3NO [M+H]: 252.0397; found: 252.0397.


1-(5-bromoindolin-1-yl)-2-chloroethan-1-one (50)



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The title compound was synthesized according to General Procedure A1 from 5-bromoindoline (39.6 mg, 0.2 mmol, 1 equiv.). Purification of the crude product by prep. TLC (25% EtOAc/hexanes) provided the title compound as an off-white solid (48.6 mg, 89%). 1H NMR (600 MHz, CDCl3) δ 8.07 (d, J=8.4 Hz, 1H), 7.32 (d, J=8.8 Hz, 2H), 4.17 (t, J=8.6 Hz, 2H), 4.14 (s, 2H), 3.22 (t, J=8.4 Hz, 2H); HRMS-ESI (m/z) calculated for C10H10BrClNO [M+H]: 273.9629; found: 273.9629.


2-chloro-N-(quinolin-5-yl)acetamide (51)



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To a stirring suspension of 5-aminoquinoline (28.8 mg, 0.2 mmol, 1 equiv.) and potassium carbonate (82.9 mg, 0.6 mmol, 3 equiv.) in anhydrous CH2Cl2 (3 mL) at 0° C. was added chloroacetyl chloride (24 μL, 1.5 equiv.). The reaction was allowed to slowly warm up to room temperature. After 3 hours, the mixture was filtered, washed with EtOAc (10 mL) and CH2Cl2 (10 mL). The solid cake was then eluted with MeOH (20 mL) and the filtrate concentrated in vacuo. The residue was taken up in 10% MeOH/CH2Cl2 and passed through a pad of silica to provide the title compound as an off-white solid (42.6 mg, 82%). 1H NMR (500 MHz, CDCl3) δ 8.96 (d, J=2.5 Hz, 1H), 8.71 (s, 1H), 8.20 (d, J=8.6 Hz, 1H), 8.04 (d, J=8.5 Hz, 1H), 7.94 (d, J=7.5 Hz, 1H), 7.74 (t, J=8.0 Hz, 1H), 7.48 (dd, J=8.5, 4.2 Hz, 1H), 4.35 (s, 2H); HRMS-ESI (m/z) calculated for C11H9ClN2O [M+H]: 221.0476; found: 221.0477.


1-(4-benzylpiperidin-1-yl)prop-2-en-1-one (53)



embedded image


Following General Procedure B, starting from 4-benzylpiperidine (1 g, 5.7 mmol, 1 equiv.), the title compound was obtained after column chromatography as a yellow oil (748 mg, 57%). 1H NMR (500 MHz, Chloroform-d) δ 7.36 (t, J=7.4 Hz, 2H), 7.28 (t, J=7.4 Hz, 1H), 7.20 (d, J=7.1 Hz, 2H), 6.64 (dd, J=16.8, 10.6 Hz, 1H), 6.32 (dd, J=16.8, 1.9 Hz, 1H), 5.72 (dd, J=10.6, 1.9 Hz, 1H), 4.72 (d, J=12.7 Hz, 1H), 4.03 (d, J=13.0 Hz, 1H), 3.05 (t, J=12.7 Hz, 1H), 2.70-2.59 (m, 3H), 1.86 (ddp, J=14.6, 7.2, 3.5 Hz, 1H), 1.77 (m, 2H), 1.37-1.18 (m, 2H); HRMS-ESI (m/z) calculated for C15H20ClNO [M+H]: 230.1539; found: 230.1539.


2-chloro-N-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methyl)acetamide (54)



embedded image


To a stirred solution of pyridoxamine hydrochloride (150 mg, 0.64 mmol, 1 equiv.) in anhydrous MeOH (20 mL) at room temperature was added sodium metal (30 mg, 1.5 mmol, 2.3 equiv.), TEA (100 μL, 1 mmol, 1.6 equiv.). Chloroacetic anhydride (390 mg, 2.29 mmol, 3.5 equiv.) was added and the mixture stirred for 6 h, monitoring for completeness by TLC. After which, the reaction mixture was concentrated in vacuo. The crude product then was the purified by prep. TLC to afford the title compound as a white solid (46 mg, 30%). 1H NMR (500 MHz, Methanol-d4) δ 7.97 (s, 1H), 4.81 (s, 2H), 4.61 (s, 2H), 4.17 (s, 3H), 4.06 (s, 1H), 3.35 (s, 1H), 2.52 (s, 3H); HRMS-ESI (m/z) calculated for C10H14ClN2O3 [M+H]: 245.0687; found: 245.0688.


1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)prop-2-en-1-one (56)



embedded image


To a stirring suspension of the 6,7-dimethoxy-3,4-dihydroisoquinoline (1 g, 5.2 mmol, 1 equiv.) and TEA (1800 μL, 12.6 mmol, 2.5 equiv.) in anhydrous THF (10 mL) at 0° C. was added acryloyl chloride (1320 μL, 13.2 mmol, 2.6 equiv.) and the reaction was allowed to slowly warm up to room temperature. After 2 hours, the mixture was diluted with CH2Cl2 (2×50 mL) and washed with saturated brine (2×50 mL) and the combined organics were concentrated in vacuo. The residue was taken up in 10% MeOH/CH2Cl2 and purified by column chromatography to afford the title compound as a white solid (700 mg, 54%, mixture of E/Z isomers). 1H NMR (500 MHz, Chloroform-d) δ 6.63 (m, 3H), 6.29 (d, J=16.8 Hz, 1H), 5.69 (dd, J=10.6, 1.8 Hz, 1H), 4.69 (s, 1H [major]), 4.63 (s, 0.8H [minor]), 3.82 (s, 7H), 3.73 (t, J=5.6 Hz, 1H), 2.84-2.77 (m, 2H); HRMS-ESI (m/z) calculated for C14H18NO3 [M+H]: 248.128; found: 248.1281.


2-chloro-N-(1-(3-ethynylbenzyl)piperidin-4-yl)-N-phenylacetamide (61)



embedded image


To an excess of neat SI-3 was added 0.7 mL of trifluoroacetic acid (0.2 M). The resulting solution was concentrated under a stream of nitrogen until no further evaporation was observed, providing the deprotected amine as its trifluoroacetate salt. The trifluoroacetate amine salt (90.6 mg, 0.25 mmol) was taken up in DMF (0.5 mL, 0.5 M) and the resulting solution was cooled to 0° C. 3-ethynyl benzoic acid (44 mg, 1.2 equiv.), HATU (113 mg, 1.2 equiv.), and Hunig's base (86 μL, 2 equiv.) were sequentially added. The reaction was stirred for 2 hours at 0° C., diluted with Et2O, and then washed with 1 M HCl. The organic layer was dried over magnesium sulfate, concentrated, and purified by flash chromatography (gradient from 40 to 70% ethyl acetate in hexanes) to provide the title compound (87 mg, 92%). 1H NMR (400 MHz, Chloroform-d) δ 7.51 (dd, J=9.5, 5.4 Hz, 4H), 7.43 (d, J=1.9 Hz, 1H), 7.39-7.25 (m, 2H), 7.14 (d, J=10.4 Hz, 2H), 4.86 (tt, J=15.1, 5.3 Hz, 2H), 3.72 (s, 3H), 3.19 (d, J=14.0 Hz, 1H), 3.11 (s, 1H), 2.86 (s, 1H), 1.90 (d, J=36.6 Hz, 2H), 1.38 (s, 1H), 1.24 (d, J=19.9 Hz, 1H); HRMS-ESI (m/z) calculated for C22H22C1N2O2 [M+H]: 381.1364; found: 381.1363.


Example 2

Animal Treatment


Female DBA/1 mice (7-10 week of age) are purchased from The Jackson Laboratory (Bar Harbor, Me.), and are kept for 1 week before treatments. The animal facilities are certified by the Association for Assessment and Accreditation of Laboratory Animal Care. An illustrative compound from FIG. 1, compound A, is used for this study. The animals are injected i.p. with about 50 mg/kg of compound A (dissolved in phosphate-buffered saline) or vehicle four times weekly for 3 weeks. Four days after the last dose, mice are scarified, and splenocytes and lymph node cells are isolated for ex vivo T-cell proliferation assays.


Lymph Node and Splenic T-Cell Proliferation Assay


Splenocytes and lymph node cells obtained from the Animal Treatment study are separately pooled from three to five mice, and single-cell suspension are prepared. The cells (about 1×106 cells/well) are stimulated with 10 μg/ml of compound A, and then incubated for 4 days in a 96-well plate in DMEM containing 10% fetal calf serum (FCS). During the last 16 hours, the cells are pulsed with [3H]thymidine (0.5 μCi/well), and T-cell proliferation is determined by thymidine uptake. In the lymph node proliferation assay, serum-free X-VIVO medium is used.


Electrophoresis Analysis


Splenocytes and lymph node cells obtained from the Animal Treatment study are separately pooled and centrifuged to collect the respective cell pellet. The cell pellet is subsequently lysed and resolved on a 10-12% polyacrylamide gel. Protein bands are subsequently visualized by silver staining.


Example 3

Tumor Cell Lines and Mice


Six to eight-week female C57BL and C3H mice are purchased (Charles River Laboratories, Wilmington, Mass.). The animal facilities are certified by the Association for Assessment and Accreditation of Laboratory Animal Care.


ID8 is a clone of the MOSEC ovarian carcinoma of C57BL/6 origin. SW1 is a clone derived from the K1735 melanoma of C3H origin.


In Vivo Studies


In experiments with the ID8 ovarian carcinoma, mice (5 or 10/group) are transplanted i.p. with 3×106 cells. Either 10 or 15 days later, they are injected i.p. with compound A or vehicle, which is repeated weekly for a total of 3 times. Mice are monitored daily for tumor growth, including swollen bellies indicating that they have developed ascites, and for evidence of toxicity. Tumor growth is recorded using a digital caliper. The survival of each mouse is further recorded and overall survival is calculated as mean±standard error of mean (M±SEM).


In experiments with the SW1 melanoma, 5×105 cells are transplanted s.c. on the right flank, When the mice have developed tumors of about 4-5 mm in mean diameter, they are randomized into treatment group and control group; with either compound A or vehicle injected i.p., respectively, at weekly intervals for a total of 3 times. Mice are monitored daily for evidence of toxicity. Tumor diameters are measured twice/week using a digital caliper and tumor surfaces are calculated. Overall survival is also recorded.


Example 4

Phase 1 Clinical Trial


Purpose: this clinical trial is to assess the safety and tolerability of administration of compound A in combination with low-dose cytokines (IL-2 and IFN-alpha) in patients with metastatic or refractory cancer.


Study Type: Interventional


Study Design: Allocation: Non-Randomized


Intervention Model: Single Group Assignment


Masking: Open Label


Primary Purpose: Treatment


Primary Outcome Measures:

    • Safety [Time Frame: Initial dose of study therapy through 30 days post last dose of study therapy]
    • Tolerability [Time Frame: Initial dose of study therapy through 30 days post last dose of study therapy]
    • Anti-tumor Activity [Time Frame: From initial dose of study therapy to disease progression]


Eligibility


Ages Eligible for Study: 18 Years and older (Adult, Senior)


Sexes Eligible for Study: All


Accepts Healthy Volunteers: No


Criteria


Inclusion Criteria:

    • Have a histologically confirmed diagnosis of metastatic or refractory cancer for which there are no effective standard therapeutic options available;
    • Have signed an Institutional Review Board (IRB) approved informed consent form (ICF) prior to performing any study evaluation/procedures;
    • Be > or =18 years of age and women must either be 1) not of childbearing potential or 2) have a negative serum pregnancy test within 7 days prior to commencing treatment. Patients are considered not of childbearing potential if they are surgically sterile (they have undergone a hysterectomy, bilateral tubal ligation or bilateral oophorectomy) or they are postmenopausal (12 consecutive months of amenorrhea [lack of menstruation]);
    • (If applicable) Have completed prior cytotoxic chemotherapy, radiotherapy or immunotherapy or experimental therapy > or =30 days prior to the study enrollment, and recovered form associated toxicities;
    • Have an Eastern Cooperative Oncology Group (ECOG) score of < or =2, and an anticipated life expectancy of at least 6 months;
    • Have adequate hematologic function, as defined by an absolute or calculated neutrophil count > or =1500/microL, platelet count > or =100000/microL, lymphocyte count > or =500/microL, and hemoglobin level > or =10 g/dL. Patients may not receive prophylactic transfusion in order to qualify for trial eligibility;
    • Have adequate renal function, as defined by a documented serum creatinine of < or =2.0 mg/dL. Greater than “1+” proteinuria will require microscope evaluation and the results discussed with the medical monitor prior to patient enrollment; or if serum creatine is >2.0, patient must have an actual or calculated 24-hour creatinine clearance of >60 mL/min and no obvious evidence of concurrent medullary cystic disease or obstructive uropathy;
    • Have adequate hepatic function, as defined by a total bilirubin level < or =1.5× upper limit of normal (ULN) and alkaline phosphatase, aspartate transaminase (AST), and alanine transaminase (ALT) levels < or =2.5×ULN. If alkaline phosphatase is outside of these parameters and is due to bone metastases (as verified by the assessment of isoenzymes), then the patient is eligible.


Exclusion Criteria:

    • Have a history of severe hypersensitivity (grade 3-4 allergic reaction) to fluorescein or any drug, radiologic contrast agent, insect bite, food, cytokines, or any other agent; or have received fluorescein within 30 days of the study;
    • Have medical conditions that preclude the use of IL-2 or IFN-alpha. These conditions include but are not limited to, diabetes mellitus with a history of progression to diabetic ketoacidosis, history of severe coagulation disorder, psoriasis, sarcoidosis, retinal hemorrhage, symptomatic pulmonary disease, heart failure (> or =New York Heart Association NYHA class II), or transplant requiring immunosuppressive therapy;
    • Be pregnant or breast-feeding;
    • Be currently receiving an experimental drug, or used an experimental device within 30 days of study entry;
    • Be currently undergoing chemotherapy, anticancer hormonal therapy, and/or therapy with immunosuppressant agents;
    • Have any concomitant malignancy with the exception of basal cell or squamous cell carcinoma of skin;
    • Have radiographically documented evidence of current brain metastases, a history of stem cell transplant, immunodeficiency, and/or a medical or psychiatric illness (that in the investigator's opinion, would prevent adequate compliance with study therapy or evaluation of the endpoints).


Example 5

Tables 1-5 illustrate exemplary lists of cysteine-containing polypeptides.


Table 1 illustrates an exemplary list of liganded cysteines which are identified from isoTOP-ABPP experiments performed in cell lysates (in vitro). Table 1 further shows the accession number (or the protein identifier) of the protein, cysteine residue number, and an illustrative peptide fragment containing the cysteine of interest (denoted by C*). For example, P23396 (row 2, col 1) is the accession number (or protein identifier) of RPS3 40S ribosomal protein S3. C97 (row 2, col 1) is the cysteine residue number of interest. The peptide fragment: R.GLC*AIAQAESLR.Y (SEQ ID NO: 1) is an illustrative peptide fragment of RPS3 40S ribosomal protein S3 containing the cysteine residue C97 and is denoted by C*.












TABLE 1








SEQ ID


Identifier
Protein Name
Illustrative Cysteine Fragment
NO:


















P23396_
RPS3 40S ribosomal protein S3
R.GLC*AIAQAESLR.Y
1


C97








P68366_
TUBA4A Tubulin alpha-4A chain
K.AYHEQLSVAEITNAC*FEPANQMVK.C
2


C295








P68366_
TUBA4A Tubulin alpha-4A chain
K.RSIQFVDWC*PTGFK.V
3


C347








Q71U36_
TUBA1A Tubulin alpha-1A chain
K.RTIQFVDWC*PTGFK.V
4


C347








Q71U36_
TUBA1A Tubulin alpha-1A chain
R.AVC*MLSNTTAIAEAWAR.L
5


C376








Q7L1Q6_
BZW1 Basic leucine zipper and W2
K.ERFDPTQFQDC*IIQGLTETGTDLEAVAK.
6


C35
domain-containing protein
F






P04406_
GAPDH Glyceraldehyde-3-phosphate
K.IISNASC*TTNCLAPLAK.V
7


C152
dehydrogenase







Q99873_
PRMT1 Protein arginine N-
K.VIGIEC*SSISDYAVK.I
8


C109
methyltransferase 1







Q15365_
PCBP1 Poly(rC)-binding protein 1
R.LVVPATQC*GSLIGK.G
9


C109








Q13526_
PIN1 Peptidyl-prolyl cis-trans
K.IKSGEEDFESLASQFSDC*SSAK.A
10


C113
isomerase NIMA-interacting 1







Q9Y266_
NUDC Nuclear migration protein
R.WTQTLSELDLAVPFC*VNFR.L
11


C188
nudC







Q9Y696_
CLIC4 Chloride intracellular channel
K.AGSDGESIGNC*PFSQR.L
12


C35
protein 4







P24752_
ACAT1 Acetyl-CoA
R.QAVLGAGLPISTPC*TTINK.V
13


C119
acetyltransferase, mitochondrial







P10809_
HSPD1 60 kDa heat shock protein,
R.AAVEEGIVLGGGC*ALLR.C
14


C442
mitochondrial







P68366_
TUBA4A Tubulin alpha-4A chain
K.YMAC*CLLYR.G
15


C315








P09211_
GSTP1 Glutathione S-transferase P
K.ASC*LYGQLPK.F
16


C48








Q86SX6_
GLRX5 Glutaredoxin-related protein
K.GTPEQPQC*GFSNAVVQILR.L
17


C67
5, mitochondrial







P13639_
EEF2 Elongation factor 2
K.STLTDSLVC*K.A
18


C41








O14980_
XPO1 Exportin-1
K.LDINLLDNVVNC*LYHGEGAQQR.M
19


C34








Q15365_
PCBP1 Poly(rC)-binding protein 1
R.VMTIPYQPMPASSPVIC*AGGQDR.C
20


C194








Q99832_
CCT7 T-complex protein 1 subunit eta
K.EGTDSSQGIPQLVSNISAC*QVIAEAVR.T
21


C29








P62280_
RPS11 40S ribosomal protein S11l
K.C*PFTGNVSIR.G
22


C60








P78417_
GSTO1 Glutathione S-transferase
R.FC*PFAER.T
23


C32
omega-1







P24752_
ACAT1 Acetyl-CoA
K.IHMGSC*AENTAK.K
24


C196
acetyltransferase, mitochondrial







P10599_
TXN Thioredoxin
K.LVVVDFSATWC*GPCK.M
25


C32








P50990_
CCT8 T-complex protein 1 subunit
KIAVYSC*PFDGMITETK.G
26


C244
theta







P13667_
PDIA4 Protein disulfide-isomerase A4
K.ENFDEVVNDADIILVEFYAPWC*GHCK.K
27


C206








P55735_
SEC13 Protein SEC13 homolog
R.FASGGC*DNLIK.L
28


C187








Q15185_
PTGES3 Prostaglandin E synthase 3
K.HLNEIDLFHC*IDPNDSK.H
29


C58








P55263_
ADK Adenosine kinase
R.TGC*TFPEKPDFH
30


C353








P46782_
RPS5 40S ribosomal protein S5
K.AQC*PIVER.L
31


C66








Q99439_
CNN2 Calponin-2
K.AGQC*VIGLQMGTNK.C
32


C164








P13639_
EEF2 Elongation factor 2
R.VTDGALVVVDCVSGVC*VQTETVLR.Q
33


C136








Q2TAA2_
IAH1 Isoamyl acetate-hydrolyzing
R.VILITPTPLC*ETAWEEQCIIQGCK.L
34


C137
esterase 1 homolog







P30044_
PRDX5 Peroxiredoxin-5,
K.ALNVEPDGTGLTC*SLAPNIISQL
35


C204
mitochondrial







P12268_
IMPDH2 Inosine-5-monophosphate
R.HGFC*GIPITDTGR.M
36


C140
dehydrogenase 2







Q99714_
HSD17810 3-hydroxyacyl-CoA
K.VC*NFLASQVPFPSR.L
37


C214
dehydrogenase type-2







Q9NQR4_
NIT2 Omega-amidase NIT2
R.VGLGIC*YDMR.F
38


C153








P15121_
AICR1B1 Aldose reductase
R.VC*ALLSCTSHK.D
39


C299








Q6UB35_
MTHFD1L Monofunctional C1 -
K.IDRYTQQGFGNLPIC*MAK.T
40


C906
tetrahydrofolate synthase,





mitochondrial







P07437_
TUBB Tubulin beta chain
K.LTTPTYGDLNHLVSATMSGVTTC*LR.F
41


C239








Q15084_
PDIA6 Protein disulfide-isomerase A6
R.EVIQSDSLWLVEFYAPWC*GHCQR.L
42


C55








P14618_
PKM Pyruvate kinase isozymes
K.C*CSGAIIVLTK.S
43


C423
M1/M2







P62266_
RPS23 40S ribosomal protein S23
K.ITAFVPNDGC*LNFIEENDEVLVAGFGR.K
44


C90








Q71U36_
TUBA1A Tubulin alpha-1A chain
MRECISIHVGQAGVQIGNAC*WELYCLEHG
45


C20

IQPDGQMPSDK.T






O95336_
PGLS 6-phosphogluconolactonase
R.AAC*CLAGAR.A
46


C32








P24752_
ACAT1 Acetyl-CoA
K.QGEYGLASIC*NGGGGASAMLIQK.L
47


C413
acetyltransferase, mitochondrial







P62701_
RPS4X 40S ribosomal protein S4, X
K.LREC*LPLIIFLR.N
48


C41
isoform







P62829_
RPL23 60S ribosomal protein L23
R.ISLGLPVGAVINC*ADNTGAK.N
49


C28








Q71U36_
TUBA1A Tubulin alpha-1A chain
R.ECISTHVGQAGVQIGNACWELYC*LEHGI
50


C25

QPDGQMPSDK.T






Q96HE7_
ERO1L ERO1-like alpha
K.HDDSSDNFC*EADDIQSPEAEYVDLLLNP
51


C166
protein
ER.Y






Q96HE7_
ERO1L ERO1-like protein alpha
K.RPLNPLASGQGTSEENTFYSWLEGLC*VE
52


C241

K.R






Q9BRA2_
TXNDC17 Thioredoxin domain-
K.SWC*PDCVQAEPVVR.E
53


C43
containing protein 17







P13667_
PDIA4 Protein disulfide-isomerase A4
K.DVLIEFYAPWC*GHCK.Q
54


C555








P30101_
PDIA3 Protein disulfide-isomerase A3
K.DVLIEFYAPWC*GHCK.N
55


C406








P07437_
TUBB Tubulin beta chain
K.TAVC*DIPPR.G
56


C354








P83731_
RPL24 60S ribosomal protein L24
K.C*ESAFLSK.R
57


C36








Q9ULV4_
CORO1C Coronin-1C
K.C*DLISIPK.K
58


C420








P42677_
RPS27 40S ribosomal protein S27
R.LTEGC*SFR.R
59


C77








O00299_
CLIC1 Chloride intracellular channel
KIGNC*PFSQR.L
60


C24
protein 1







P49458_
SRP9 Signal recognition particle 9
K.VTDDLVC*LVYK.T
61


C48
kDa protein







P42765_
ACAA2 3-ketoacyl-CoA thiolase,
R.LC*GSGFQSIVNGCQEICVK.E
62


C92
mitochondrial







Q15233_
NONO Non-POU domain-containing
R.FAC*HSASLTVR.N
63


C145
octamer-binding protein







P50570_
DNM2 Dynamin-2
K.LQDAFSSIGQSC*HLDLPQIAVVGGQSAG
64


C27

K.S






P25205_
MCM3 DNA replication licensing
R.TLTSC*FLSCVVCVEGIVTK.C
65


C119
factor MCM3







Q5TFE4_
NT5DC1 5-nucleotidase domain-
K.HFLSDTGMAC*R.S
66


C119
containing protein 1







Q99439_
CNN2 Calponin-2
K.C*ASQVGMTAPGTR.R
67


C215








Q06323_
PSME1 Proteasome activator complex
K.VDVFREDLC*TK.T
68


C22
subunit 1







P49591_
SARS Serine--tRNA ligase,
R.TIC*AILENYQTEK.G
69


C438
cytoplasmic







Q96RS6_
NUDCD1 NudC domain-containing
R.DSAQC*AAIAER.L
70


C376
protein 1







Q71U36_
TUBA1A Tubulin alpha-1A chain
K.LADQC*TGLQGFLVFHSFGGGTGSGFTSL
71


C129

LMER.L






Q9BXJ9_
NAA15 N-alpha-acetyltransferase 15,
R.LFNTAVC*ESK.D
72


C721
NatA auxiliary subunit







P33240_
CSTF2 Cleavage stimulation factor
K.LC*VQNSPQEAR.N
73


C150
subunit 2







Q13155_
AIMP2 Aminoacyl tRNA synthase
K.SPWLAGNELTVADVVLWSVLQQIGGC*S
74


C291
complex-interacting multif
VTVPANVQR.W






O75663_
T1PRL TIP41-like protein
K.VAC*AEEWQESR.T
75


C87








P63244_
GNB2L1 Guanine nucleotide-binding
K.VWNLANC*K.L
76


C182
protein subunit beta-2-like 1







Q7L2H7_
EIF3M Eukaryotic translation
K.VAASC*GAIQYIPTELDQVR.K
77


C134
initiation factor 3 subunit







P49327_
FASN Fatty acid synthase
K.LTPGC*EAEAETEAICFFVQQFTDMEHNR.
78


C2359

V






P42166_
TMPO Lamina-associated polypeptide
K.VDDEILGFISEATPLGGIQAASTESC*NQQ
79


C561
2, isoform alpha
LDLALCR.A






P24752_
ACAT1 Acetyl-CoA
K.VC*ASGMK.A
80


C126
acetyltransferase, mitochondrial







P36578_
RPL4 60S ribosomal protein L4
R.SGQGAFGNMC*R.G
81


C96








Q9NXG2_
THUMPD1 THUMP domain-
R.RC*DAGGPR.Q
82


C31
containing protein 1







P07237_
P4HB Protein disulfide-isomerase
K.KNVFVEFYAPWC*GHCK.Q
83


C397








P27707_
DCK Deoxycytidine kinase
R.SC*PSFSASSEGTR.I
84


C9








O00303_
EIF3F Eukaryotic translation initiation
K.TC*FSPNR.V
85


C256
factor 3 subunit







Q9UNH7_
SNX6 Sorting nexin-6
K.SAADDYNRIGSSLYALGTQDSTDIC*KFF
86


C264

LK.V






Q15084_
PDIA6 Protein disulfide-isomerase A6
K.DVIELTDDSFDKNVLDSEDVWMVEFYAP
87


C190

WC*GHCK.N






O43390_
HNRNPR Heterogeneous nuclear
K.SAFLC*GVMK.T
88


C99
ribonucleoprotein R







Q96JB2_
COG3 Conserved oligomeric Golgi
K.AAAENLPVPAELPIEDLC*SLTSQSLPIELT
89


C65
complex subunit 3
SVVPESTEDILLK.G






P46109_
CRKL Crk-Like protein
K.RVPC*AYDK.T
90


C249








P62888_
RPL30 60S ribosomal protein L30
R.VC*TLAIIDPGDSDIIR.S
91


C92








Q9NUY8_
TBC1D23 TBC1 domain family
K.FLENTPSSLNIEDIEDLFSLAQYYC*SK.T
92


C283
member 23







Q09161_
NCBP1 Nuclear cap-binding protein
K.SAC*SLESNLEGLAGVLEADLPNYK.S
93


C44
subunit 1







Q9UJW0_
DCTN4 Dynactin subunit 4
R.LLQPDFQPVC*ASQLYPR.H
94


C258








O15294_
OGT UDP-N-acetylglucosamine-
K.C*PDGGDNADSSNTALNMPVIPMNTIAE
95


C758
peptide N-acetylglucosaminyl
AVIEMINR.G




transferase







P38646_
HSPA9 Stress-70 protein,
K.AKC*ELSSSVQTDINLPYLTMDSSGPK.H
96


C317
mitochondrial







Q9HA64_
FN3KRP Ketosamine-3-kinase
R.ATGHSGGGC*ISQGR.S
97


C24








Q9Y6G9_
DYNCILI1 Cytoplasmic dynein 1
R.VGSFGSSPPGLSSTYTGGPLGNEIASGNG
98


C51
light intermediate chain 1
GAAAGDDEDGQNLWSC*ILSEVSTR.S






P52597_
HNRNPF Heterogeneous nuclear
R.DLSYC*LSGMYDHR.Y
99


C267
ribonucleoprotein F







Q99497_
PARK7 Protein DJ-1
K.GLIAAIC*AGPTALLAHEIGFGSK.V
100


C106








P57764_
GSDMD Gasdermin-D
R.C*LHNFLTDGVPAEGAFTEDFQGLR.A
101


C268








A6NDG6_
PGP Phosphoglycolate phosphatase
K.NNQESDC*VSK.K
102


C297








Q14566_
MCM6 DNA replication licensing
R.LVFLAC*CVAPTNPR.F
103


C301
factor MCM6







Q00610_
CLTC Clathrin heavy chain 1
R.IHEGC*EEPATHNALAK.I
104


C870








Q96T76_
MMS19 MMS19 nucleotide excision
R.LMGLLSDPELGPAAADGFSLLMSDC*TD
105


C848
repair protein homolog
VLTR.A






P61158_
ACTR3 Actin-related protein 3
R.YSYVC*PDLVK.E
106


C235








P23528_
CFL1 Cofilin-1
K.MLPDKDC*R.Y
107


C80








Q9NQ88_
TIGAR Fructose-2,6-bisphosphatase
K.EADQKEQFSQGSPSNC*LETSLAEIFPLGK.
108


C161
TIGAR
N






Q9UKF6_
CPSF3 Cleavage and polyadenylation
R.NFNYHILSPC*DLSNYTDLAMSTVK.Q
109


C498
specificity factor subunit







Q8TAQ2_
SMARCC2 SWI/SNF complex
R.PNIFLC*PEIEPK.L
110


C145
subunit SMARCC2







P68036_
UBE2L3 Ubiquitin-conjugating
K.GQVC*LPVISAENWKPATK.T
111


C86
enzyme E2 L3







Q9Y3A3_
MOB4 MOB-like protein phocein
R.HTLDGAAC*LLNSNK.Y
112


C134








P49588_
AARS Alanine-tRNA ligase,
K.C*LSVMEAK.V
113


C773
cytoplasmic







Q961J6_
GMPPA Mannose-1 -phosphate
K.LLPAITILGC*R.V
114


C389
guanyltransferase alpha







P27635_
RPL10 60S ribosomal protein L10
K.MLSC*AGADR.L
115


C105








O15145_
ARPC3 Actin-related protein 2/3
K.WWTC*FVK.R
116


C162
complex subunit 3







P48643_
CCT5 T-complex protein 1 subunit
K.IAILTC*PFEPPKPK.T
117


C253
epsilon







P11586_
MTHFD1 C-1-tetrahydrofolate
R.ASVGAGFLYPLVGTMSTMPGLPTRPC*F
118


C918
synthase, cytoplasmic
YDIDLDPETEQVNGLF






Q96GX2_
ATXN7L3B Putative ataxin-7-like
R.LPLC*SLPGEPGNGPDQQLQRS
119


C75
protein 3B







P17987_
TCP1 T-complex protein 1 subunit
K.VLC*ELADLQDK.E
120


C76
alpha







Q9NYL9_
TMOD3 Tropomodulin-3
K.VSLDPELEEALTSASDTELC*DLAAILGM
121


C132

HNLITNTK.F






O00429_
DNM1L Dynkamin-1-like protein
R.IC*YIFHETFGR.T
122


C367








Q13155_
AIMP2 Aminoacyl tRNA synthase
R.VELPTC*MYR.L
123


C23
complex-interacting multif







P30101_
PDIA3 Protein disulfide-isomerase A3
R.ISDTGSAGLMLVEFFAPWC*GHCK.R
124


C571








Q9ULA0_
DNPEP Aspartyl aminopeptidase
K.C*PTSGR.L
125


C144








Q9BWD1_
ACAT2 Acetyl-CoA
R.QASVGAGIPYSVPAWSCQMIC*GSGLK.A
126


C92
acetyltransferase, cytosolic







Q8NBS9_
TXNDC5 Thioredoxin domain-
K.FYAPWC*GHCK.T
127


C350
containing protein 5







P68366_
TUBA4A Tubulin alpha-4A chain
K.TIGGGDDSFTTFFC*ETGAGK.H
128


C54








P04183_
TK1 Thymidine kinase, cytosolic
R.YSSSFC*THDR.N
129


C66








Q15021_
NCAPD2 Condensin complex subunit
K.NAIQLLASFLANNPFSC*K.L
130


C439
1







QSWUM4_
PDCD6IP Programmed cell death 6-
K.HC*IMQANAEYHQSILAK.Q
131


C250
interacting protein







Q96F86_
EDC3 Enhancer of mRNA-decapping
K.DLPTSPVDLVINCLDC*PENVFLR.D
132


C413
protein 3







P35754_
GLRX Glutaredoxin-1
K.VVVFIKPTC*PYCR.R
133


C23








Q9NQ88_
TIGAR Fructose-2,6-bisphosphatase
R.EEC*PVFTPPGGETLDQVK.M
134


C114
TIGAR







P12268_
IMPDH2 Inosine-5-monophosphate
R.VGMGSGSIC*ITQEVLACGRPQATAVYK.
135


C331
dehydrogenase 2
V






P25705_
ATP5A1 ATP synthase subunit alpha,
K.TIVVSATASDAAPLQYLAPYSGC*SMGE
136


C294
mitochondrial
YFR.D






P15374_
UCHL3 Ubiquitin carboxyl-terminal
K.QTISNAC*GTIGLIHAIANNK.D
137


C95
hydrolase isozyme L3







P83731_
RPL24 60S ribosomal protein L24
K.VELC*SFSGYK.I
138


C6








Q9NX24_
NHP2 H/ACA ribonucleoprotein
K.IKADPDGPEAQAEAC*SGER.T
139


C18
complex subunit 2







Q13418_
ILK Integrin-linked protein lcinase
FSFQCPGRK.FSFQC*PGR.M
140


C346








Q13428_
TCOF1 Treacle protein
K.C*FLAQPVTLLDIYTHWQQTSELGR.K
141


C38








P24941_
CDK2 Cyclin-dependent kinase 2
R.APEILLGC*K.Y
142


C177








P43686_
PSMC4 26S protease regulatory
R.GVLMYGPPGC*GK.T
143


C210
subunit 6B







Q9BTA9_
WAC WW domain-containing adapter
R.STC*SLTPALAAHFSENLIK.H
144


C553
protein with coiled-coil







O14929_
HAT1 Histone acetyltransferase type
K.VDENFDC*VEADDVEGK.I
145


C101
B catalytic subunit







O75521_
ECI2 Enoyl-CoA delta isomerase 2,
R.WLSDEC*TNAVVNFLSR.K
146


C380
mitochondrial







P11586_
MTHFD1 C-1-tetrahydrofolate
K.QGFGNLPIC*MAK.T
147


C863
synthase, cytoplasmic







P27707_
DCK Deoxycytidine kinase
K.QLC*EDWEVVPEPVAR.W
148


C45








A0AVT1_
UBA6 Ubiquitin-like modifier-
R.KPNVGC*QQDSEELLK.L
149


C347
activating enzyme 6







Q96AB3_
ISOC2 Isochorismatase domain-
R.SVLLCGIEAQAC*ILNTTLDLLDR.G
150


C114
containing protein 2, mitochondrial







Q14203_
DCTN1 Dynactin subunit 1
K.VTFSC*AAGFGQR.H
151


C1252








Q9BTE3_
MCMBP Mini-chromosome
R.DASALLDPMEC*TDTAEEQR.V
152


C287
maintenance complex-binding protein







O95373_
IPO7 Importin-7
R.GIDQC*IPLFVEAALER.L
153


C757








P22061_
PCMT1 Protein-L-isoaspartate(D-
R.MVGC*TGK.V
154


C102
aspartate) O-methyltransferase







P55060_
CSE1L Exportin-2
K.KIC*AVGITK.L
155


C842








Q9BX19_
NAA15 N-alpha-acetyltransferase 15,
K.GC*PPVFNTLR.S
156


CC322
NatA auxiliary subunit







P62333_
PSMC6 26S protease regulatory
K.GC*LLYGPPGTGK.T
157


C170
subunit 10B







Q15398_
DLGAP5 Disks large-associated
R.YRPDMPC*FLLSNQNAVK.A
158


C129
protein 5







Q9BVC5_
C2orf49 Ashwin
R.SC*TDSELLLHPELLSQEFLLLTLEQK.N
159


C10








P62280_
RPS11 40S ribosomal protein S11
K.NMSVHLSPC*FR.D
160


C116








P42224_
STAT1 Signal transducer and
R.QQSACIGGPPNAC*LDQLQNWFTIVAESL
161


C255
activator of transcription 1
QQVR.Q






Q96RN5_
MED15 Mediator of RNA polymerase
K.QQYLC*QPLLDAVLANIR.S
162


C618
II transcription subunit







Q6UB35_
MTHFD1L Monofunctional C1-
R.ASIGAGFIYPLVGTMSTMPGLPTRPC*FY
163


C961
tetrahydrofolate synthase,
DIDLDTETEQVK.G




mitochondrial







P23919_
DTYMK Thymidylate kinase
R.C*FHQLMK.D
164


C163








Q92616_
GCN1L1 Translational activator
K.GMGESC*FEDLLPWLMETLTYEQSSVDR.
165


C1692
GCN1
S






P42166_
TMPO Lamina-associated polypeptide
K.SGIQPLC*PER.S
166


C341
2, isoform alpha







O95571_
ETHE1 Protein ETHE1,
R.TDFQQGC*AK.T
167


C170
mitochondrial







O14777_
NDC80 Kinetochore protein NDC80
K.FNPEAGANC*LVK.Y
168


C449
homolog







P36542_
ATP5C1 ATP synthase subunit
R.GLC*GAIHSSIAK.Q
169


C103
gamma, mitochondrial







Q9Y3D0_
FAM96B Mitotic spindle-associated
R.VQVSDPESTVAVAFTPTIPHC*SMATLIGL
170


C93
MMXD complex subunit Mi
SIK.V






P54136_
RARS Arginine-tRNA ligase,
K.NCGC*LGASPNLEQLQEENLK.L
171


C34
cytoplasmic







Q96T76_
MMS19 MMS19 nucleotide excision
R.YHPLSSC*LTAR.L
172


C819
repair protein homolog







Q8TBC4_
UBA3 NEDD8-activating enzyme E1
R.VILPGMTACIECTLELYPPQVNFPMC*TIA
173


C237
catalytic subunit
SMPR.L






Q13573_
SNW1 SNW domain-containing
K.IPPC*ISNWK.N
174


C250
protein 1







P46734_
MAP2K3 Dual specificity mitogen-
K.MC*DFGISGYLVDSVAK.T
175


C207
activated protein kinase







P34932_
HSPA4 Heat shock 70 kDa protein 4
R.AGGIETIANEYSDRC*TPACISFGPK.N
176


C34








Q9UBR2_
CTSZ Cathepsin Z
R.NQHIPQYCGSC*WAHASTSAMADR.I
177


C92








Q16763_
UBE2S Ubiquitin-conjugating enzyme
K.C*LLIRPNPESALNEEAGR.L
178


C118
E2 S







Q06203_
PPAT
K.C*ELENCQPFVVETLHGKI
179


C100
Amidophosphoribosyltransferase







P51649_
ALDH5A1 Succinate-semialdehyde
R.NTGQTC*VCSNQFLVQR.G
180


C340
dehydrogenase, mitochondrial







P43246_
MSH2 DNA mismatch repair protein
K.KGVC*DQSFGIHVAELANFPK.H
181


C822
Msh2







P27708_
CAD CAD protein
K.AQILVLTYPLIGNYGIPPDEMDEFGLC*K.
182


C73

W






Q16822_
PCK2 Phosphoenolpyruvate
R.YVAAAFPSAC*GK.T
183


C306
carboxylcinase







Q01813_
PFKP 6-phosphofructokinase type C
R.NESC*SENYTTDFIYQLYSEEGK.G
184


C641








Q96CM8_
ACSF2 Acyl-CoA synthetase family
R.MVSTPIGGLSYVQGC*TK.K
185


C64
member 2, mitochondrial







Q9BUK6_
MSTO1 Protein misato homolog 1
K.VVTAGAIIPFPLAPGQSLPDSLMQFGGAT
186


C403

PWTPLSAC*GEPSGTR.C






P22234_
PA1CS Multifunctional protein ADE2
R.LPSGLGC*STVLSPEGSAQFAAQIFGLSNH
187


C374

LVWSK.L






Q6ICB0_
DESI1 Desumoylating isopeptidase 1
R.GEAYNLFEHNC*NTFSNEVAQFLTGRK
188


C108








P62333_
PSMC6 26S protease regulatory
R.AVASQLDC*NFLK.V
189


C193
subunit 10B







Q8IUR0_
TRAPPC5 Trafficking protein particle
K.ENSTLNC*ASFTAGIVEAVLTHSGFPAK.V
190


C139
complex subunit 5







Q01813_
PFKP 6-phosphofructokinase type C
K.YAYLNVVGMVGSIDNDFC*GTDMTIGTD
191


C179 

SALHR.I






P38606_
ATP6V1A V-type proton ATPase
K.WDFTPC*K.N
192


C138
catalytic subunit A 







P82932_
MRPS6 28S ribosomal protein S6,
K.EC*EGIVPVPLAEK.L
193


C105
mitochondrial







Q9NS86_
LANCL2 LanC-like protein 2
R.SVVC*QESDLPDELLYGR.A
194


C187








Q9ULV4_
CORO1C Coronin-1C
K.SIKDTIC*NQDER.I
195


C456








P09110_
ACAA1 3-ketoacyl-CoA thiolase,
K.VNPLGGAVALGHPLGC*TGAR.Q
196


C381
peroxisomal







Q9HAV7_
GRPEL1 GrpE protein homolog 1,
K.ATQC*VPKEEIKDDNPHLK.N
197


C124
mitochondrial







Q14738_
PPP2R5D Serine/threonine-protein
K.C*TAKPSSSGK.D
198


C17
phosphatase 2A 56 kDa regulatory





subunit delta isoform







Q99757_
TXN2 Thioredoxin, mitochondrial
R.VVNSETPVVVDFHAQWC*GPCK.I
199


C90








P51570_
GALK1 Galactokinase
R.AQVCQQAEHSFAGMPC*GIMDQFISLMG
200


C182

QK.G






Q06330_
RBPJ Recombining binding protein
R.IIQFQATPC*PK.E
201


C313
suppressor of hairless







Q9NVC6_
MED17 Mediator of RNA polymerase
K.MELLMSALSPC*LL
202


C649
II transcription subunit







Q99832_
CCT7 T-complex protein 1 subunit eta
R.INALTAASEAAC*LIVSVDETIK.N
203


C511








Q9BTE3_
MCMBP Mini-chromosome
K.LQHINPLLPAC*LNKEESK.T
204


C325
maintenance complex-binding protein







P04183_
TK1 Thymidine kinase, cytosolic
R.KLFAPQQILQC*SPAN
205


C230








Q96S55_
WRNIP1 ATPase WRNIP1
R.SLLETNEIPSLILWGPPGC*GK.T
206


C272








Q0VGL1_
C7orf59 UPF0539 protein C7orf59
R.IPDQLGYLVLSEGAVLASSGDLENDEQA
207


C51

ASAISELVSTAC*GFR.L






Q86W42_
THOC6 THO complex subunit 6
R.LHMTIFSQSVSPC*GK.F
208


C35
homolog







O14980_
XPO1 Exportin-1
K.DLLGLC*EQKR.G
209


C528








P43246_
MSH2 DNA mismatch repair protein
K.HVIEC*AK.Q
210


C843
Msh2







Q00839_
HNRNPU Heterogeneous nuclear
R.APQC*LGK.F
211


C562
ribonucleoprotein U







Q8WW01
TSEN15 tRNA-splicing endonuclease
R.GDSEPTPGC*SGLGPGGVR.G
212


C13
subunit Sen15







O60610_
DIAPH1 Protein diaphanous homolog
R.KAGC*AVTSLLASELTK.D
213


C1227
1







Q9NVM9_
Asun Protein asunder homolog
R.ISPVDVNSRPSSC*LTNFLLNGR.S
214


C349








O15067_
PFAS
K.FC*DNSSAIQGK.E
215


C270
Phosphodbosylformylglycinamidine





synthase







P38606_
ATP6V1A V-type proton ATPase
R.VLDALFPCVQGGTTAIPGAFGC*GK.T
216


C254
catalytic subunit A







Q8NBS9_
TXNDC5 Thioredoxin domain-
K.FFAPWC*GHCK.A
217


C217
containing protein 5







P35611_
ADD1 Alpha-adducin
R.VSMILQSPAFC*EELESMIQEQFKK.G
218


C68








P42224_
STAT1 Signal transducer and
R.NLSFFLTPPC*AR.W
219


C492
activator of transcription 1







P46940_
IQGAP1 Ras GTPase-activating-like
K.KQIPAITC*IQSQWR.G
220


C781
protein IQGAP1







O95229_
ZWINT ZW10 interactor
K.DKLLC*SQLQVADFLQNILAQEDTAK.G
221


C54








Q969Q0_
RPL36AL 60S ribosomal protein
R.C*KHFELGGDK.K
222


C88
L36a-like







Q29RF7_
PDS5A Sister chromatid cohesion
R.TVQTIEAC*IANFFNQVLVLGR.S
223


C242
protein PDS5 homolog A







Q2NL82_
TSR1 Pre-rRNA-processing protein
R.DTGTVHLNELGNTQNFMLLC*PR.L
224


C126
TSR1 homolog







Q9UKX7_
NUP50 Nuclear pore complex protein
K.AC*VGNAYHK.Q
225


C151
Nup50







P18621_
RPL17 60S ribosomal protein L17
R.INPYMSSPC*HIEMILTEK.E
226


C144








P49189_
ALDH9A1 4-
K.GALMANFLTQGQVC*CNGTR.V
227


C288
trimethylaminobutyraldehyde





dehydrogenase







P45985_
MAP2K4 Dual specificity mitogen-
K.LC*DFGISGQLVDSIAK.T
228


C246
activated protein kinase







Q13428_
TCOF1 Treacle protein
K.KGAGNPQASTLALQSNITQC*LLGQPWPL
229


C1298

NEAQVQASVVK.V






Q9BRF8_
CPPED1 Calcineurin-like
K.AWSTGDC*DNGGDEWEQEIR.L
230


C54
phosphoesterase domain-containing







O00170_
AIP AH receptor-interacting protein
R.HCC*GVAQMR.E
231


C122








Q9UNI6_
DUSP12 Dual specificity protein
R.QAQC*TSYFIEPVQWMESALLGVMDGQL
232


C265
phosphatase 12
LCPK.C






P52657_
GTF2A2 Transcription initiation
R.FC*DNVWTFVLNDVEFR.E
233


C68
factor IIA subunit 2







O15067_
PFAS
R.GLAPLHWADDDGNPTEQYPLNPNGSPGG
234


C1287
Phosphoribosylformylglycinamidine
VAGICSC*DGR.H




synthase










P37235_
HPCAL1 Hippocalcin-like protein 1
R.LLQC*DPSSASQF
235


C185








P53602_
MVD Diphosphomevalonate
R.DGDPLPSSLSC*K.V
236


C108
decarboxylase







Q96C19_
EFHD2 EF-hand domain-containing
K.AAAGELQEDSGLC*VLAR.L
237


C172
protein D2







Q9NQC3_
RTN4 Reticulon-4
K.YSNSALGHVNC*TIK.E
238


C1101








O43175_
PHGDH D-3-phosphoglycerate
K.NAGNC*LSPAVIVGLLK.E
239


C369
dehydrogenase







Q99638_
RAD9A Cell cycle checkpoint control
R.LVVQLHC*K.F
240


C114
protein RAD9A







Q06830_
PRDX1 Peroxiredoxin-1
K.LNCQVIGASVDSHFC*HLAWVNTPK.K
241


C83








Q00796_
SORD Sorbitol dehydrogenase
R.MHSVGIC*GSDVHYWEYGR.I
242


C45








Q9NRG0_
CHRAC1 Chromatin accessibility
K.ATELFVQC*LATYSYR.H
243


C55
complex protein 1







P31949_
S100A11 Protein S100-A11
K.KLDTNSDGQLDFSEFLNLIGGLAMAC*H
244


C91

DSFLK.A






Q9NY65_
TUBA8 Tubulin alpha-8 chain
R.TIQFVDWC*PTGFK.V
245


C347








Q9NXV6_
CDKN2AIP CDKN2A-interacting
K.SVYLGTGC*GK.S
246


C516
protein







Q13162_
PRDX4 Peroxiredoxin-4
R.TREEEC*HFYAGGQVYPGEASR.V
247


C51








Q14997_
PSME4 Proteasome activator complex
K.QQFTDDQLLVLTDLLVSPC*YYA
248


C1840
subunit 4







Q15003_
NCAPH Condensin complex subunit 2
R.TMC*PLLSMXPGEYSYFSPR.T
249


C418








Q01433_
AMPD2 AMP deaminase 2
R.SLPGPAPC*LK.H
250


C107








O75874_
IDH1 Isocitrate dehydrogenase
K.SEGGFIWAC*K.N
251


C269








Q29RF7_
PDS5A Sister chromatid cohesion
R.ELLDLHKQPTSEANC*SAMFGK.L
252


C532
protein PDS5 homolog A







P11498_
PC Pyruvate carboxylase,
FLYECPWRR.FLYEC*PWR.R
253


C622
mitochondrial







P49411_
TUFM Elongation factor Tu,
K.NMITGTAPLDGC*ILVVAANDGPMPQTR.
254


C147
mitochondrial
E






Q9H0C8_
ILKAP Integrin-linked kinase-
R.C*GVTSVPDIR.R
255


C301
associated serine/threonine







Q02252_
ALDH6A1 Methyhrialonate-
R.C*MALSTAVLVGEAK.K
256


C317
semialdehyde dehydrogenase







O00487_
PSMD14 26S proteasome non-
K.SWMEGLTLQDYSEHC*K.H
257


C238
ATPase regulatory subunit 14







P23919_
DTYMK Thymidylate kinase
K.ENFSLDWC*K.Q
258


C117








O75362_
ZNF217 Zinc finger protein 217
R.C*IPQLDPFTTFQAWQLATK.G
259


C286








P10644_
PRKAR1A cAMP-dependent protein
R.EC*ELYVQK.H
260


C18
kinase type I-alpha regulatory subunit





alpha







P51610_
HCFC1 Host cell factor 1
R.VAGINAC*GR.G
261


C1872








P0CB43_
FAM203B Protein FAM203B
R.HVLALTGC*GPGR.A
262


C51








O60825_
PFKFB2 6-phosphofructo-2-
K.VFFVESVC*DDPDVIAANILEVK.V
263


C158
kinase/fructose-2,6-bisphosphatase







Q15813_
TBCE Tubulin-specific chaperone E
R.NCAVSC*AGEK.G
264


C141








P30044_
PRDX5 Peroxiredoxin-5,
K.GVLFGVPGAFTPGC*SK.T
265


C100
mitochondrial







Q8N1F7_
NUP93 Nuclear pore complex protein
K.SSGQSAQLLSHEPGDPPC*LR.R
266


C522
Nup93







Q9P0J1_
PDP1
R.GMLLGVFDGHAGC*ACSQAVSER.L
267


C149








P07858_
CTSB Cathepsin B
R.GQDHC*GIESEVVAGEPR.T
268


C319








P12814_
ACTN1 Alpha-actinin-1
R.MVSDINNAWGC*LEQVEK.G
269


C370








O15294_
OGT UDP-N-acetylglucosamine-
K.VMAEANHFIDLSQIPC*NGK.A
270


C620
peptide N-acetylglucosaminyl





transferase







Q86WS5_
TMPRSS12 Transmembrane protease
R.RREGGAHAEDC*GTAPLK.D
271


C64
serine 12







Q9NQW6_
ANLN Actin-binding protein anillin
K.NNAFPC*QVNIK.Q
272


C712








Q9NY27_
PPP4R2 Serine/threonine-protein
K.EVC*PVLDQFLCHVAIGT
273


C22
phosphatase 4 regulatory







P40763_
STAT3 Signal transducer and
R.QQIACIGGPPNIC*LDRLENWITSLAESQL
274


C259
activator of transcription 3
QTR.Q






O60701_
UGDH UDP-glucose 6-
K.ASVGFGGSC*FQKDVLNLVYLCEALNLP
275


C276
dehydrogenase
EVAR.Y






Q09666_
AHNAK Neuroblast differentiation-
R.EVFSSC*SSEVVLSGDDEEYQR.I
276


C108
associated protein AHNA







P49773_
HINT1 Histidine triad nucleotide-
K.C*AADLGLNK.G
277


C84
binding protein 1







O95071_
UBR5 E3 ubiquitin-protein ligase
R.SFYTAIAQAFLSNEKLPNLEC*IQNANK.G
278


C2314
UBR5







Q9Y3Z3_
SAMHD1 SAM domain and HD
K.NPIDHVSFYC*K.T
279


C522
domain-containing protein 1







O75717_
WDHD1 WD repeat and HMG-box
K.MLALSC*K.L
280


C773
DNA-binding protein 1







Q9NPF4_
OSGEP Probable tRNA
R.AMAHCGSQEALIVGGVGC*NVR.L
281


C265
threonylcarbamoyladenosine





biosynthesis protein OSGEP







P16455_
MGMT Methylated-DNA-protein-
R.VVC*SSGAVGNYSGGLAVK.E
282


C150
cysteine methyltransferase







P49327_
FASN Fatty acid synthase
R.HAQPTC*PGAQLCTVYYASLNFR.D
283


C1558








Q96GG9_
DCUN1D1 DCN1-like protein 1
R.AATQC*EFSK.Q
284


C115








P13797_
PL,S3 Plastin-3
K.DELDELKEAFAKVDLNSNGFIC*DYELHE
285


C33

LFK.E






P37198_
NUP62 Nuclear pore glycoprotein p62
K.DIIEHLNTSGAPADTSDPLQQIC*K.I
286


C475








P00813_
ADA Adenosine deaminase
K.FDYYMPAIAGC*R.E
287


C75








O75153_
KIAA0664 Clustered mitochondria
R.IATPFQVYSWTAPQAEHAMDC*VR.A
288


C333
protein homolog







A6NDU8_
C5orf51 UPF0600 protein C5orf51
R.C*PIQLNEGVSFQDLDTAK.L
289


C179








Q9BWU1_
CDK19 Cyclin-dependent kinase 19
R.ITSEQALQDPYFQEDPLPTLDVFAGC*QIP
290


C349

YPK.R






Q15208_
STK38 Serine/threonine-protein
K.LSDFGLC*TGLK.K
291


C234
kinase 38







Q9UKV3_
ACIN1 Apoptotic chromatin
K.AAPC*IYWLPLTDSQIVQK.E
292


C1223
condensation inducer in the nucleus







P45984_
MAPK9 Mitogen-activated protein
R.TAC*TNFMMTPYVVTR.Y
293


C177
kinase 9







Q14204_
DYNC1H1 Cytoplasmic dynein 1
K.TSAPITC*ELLNK.Q
294


C1999
heavy chain 1







P29590_
PML Protein PML
R.LQDLSSC*ITQGK.D
295


C389








P62333_
PSMC6 26S protease regulatory
R.DHQPC*IIFMDEIDAIGGR.R
296


C228
subunit 10B







P13796_
LCP1 Plastin-2
K.EGIC*AIGGTSEQSSVGTQHSYSEEEK.Y
297


C101








Q9NWV8_
BABAM1 BRISC and BRCA1-A
R.TILVYSRPPC*QPQFSLTEPMKK.M
298


C222
complex member 1







O14879_
IFIT3 Interferon-induced protein with
K.GLNPLNAYSDLAEFLETEC*YQTPFNK.E
299


C343
tetratricopeptide







P50749_
RASSF2 Ras association domain-
R.ILQGPC*EQISK.V
300


C251
containing protein 2







O43396_
TXNL1 Thioredoxin-like protein 1
R.GC*GPCLR.I
301


C34








P35658_
NUP214 Nuclear pore complex
K.AC*FQVGTSEEMK.M
302


C728
protein Nup214







P42166_
TMPO Lamina-associated polypeptide
K.GGTLFGGEVC*K.V
303


C684
2, isoform alpha







Q96FX7_
TRMT61A tRNA (adenine(58)-N(1))-
R.FCSFSPC*IEQVQR.T
304


C209
methyltransferase catalytic







Q71U36_
TUBA1A Tubulin alpha-1A chain
K.LEFSIYPAPQVSTAVVEPYNSILTTHTTLE
305


C200

HSDC*AFMVDNEAIYDICR.R






O75822_
EIF3J Eukaryotic translation initiation
K.ITNSLTVLC*SEK.Q
306


C207
factor 3 subunit







Q9UBQ7_
GRHPR Glyoxylate
R.QPRPEEAAEFQAEFVSTPELAAQSDFTVV
307


C216
reductase/hydroxypyruvate reductase
AC*SLTPATEGLCNK.D






P51946_
CCNH Cyclin-H
K.ENRTC*LSQLLDIMK.S
308


C244








P05091_
ALDH2 Aldehyde dehydrogenase,
K.SPNIIMSDADMDWAVEQAHFALFFNQGQ
309


C319
mitochondrial
CC*CAGSR.T






Q9NZL4_
HSPBP1 Hsp70-binding protein 1
R.LLDRDAC*DTVR.V
310


C204








O75439_
PMPCB Mitochondrial-processing
K.FIEFGDSLC*THK.G
311


C265
peptidase subunit beta







Q16527_
CSRP2 Cysteine and glycine-rich
R.C*CFLCMVCR.K
312


C33
protein 2







Q8TC07_
TBC1D15 TBC1 domain family
R.TLLVNC*QNK.S
313


C197
member 15







P07858_
CTSB Cathepsin B
K.IC*EPGYSPTYK.Q
314


C211








Q15149_
PLEC Plectin
K.GRLC*FEGLR.S
315


C3110








Q9NUP9_
LIN7C Protein lin-7 homolog C
R.VLQSEFC*NAVR.E
316


C47








Q14683_
SMC1A Structural maintenance of
R.EALIEIDYGDLC*EDLKDAQAEEEIKQEM
317


C987
chromosomes protein lA
NTLQQK.L






P09110_
ACAA1 3-ketoacyl-CoA thiolase,
K.ARDC*LIPMGITSENVAER.F
318


C177
peroxisomal







A9UHW6_
MEF4GD MIF4G domain-containing
K.VANVIVDHSLQDC*VFSK.E
319


C49
protein







Q9NPH0_
ACP6-Lysophosphatidic acid
R.MGIDSSDKVDFFILLDNVAAEQAHNLPSC
320


C267
phosphatase type 6
*PMLK.R






Q92878_
RAD50 DNA repair protein RAD50
RAD50 K.C*SVSSLGFNVH
321


C1302








O14933_
UBE2L6 Ubiquitin/ISG15-
K.IYHPNVDENGQICLPIISSENWKPC*TK.T
322


C98
conjugating enzyme E2 L6







P39023_
RPL3 60S ribosomal protein L3
K.VAC*IGAWHPAR.V
323


C253








Q9UHD8_
SEPT9 Septin-9
K.WGTIEVENTTHC*EFAYLR.D
324


C531








P42167_
TMPO Lamina-associated polypeptide
K.EMFPYEASTPTGISASC*R.R
325


C363
2, isoforms beta/gamma







Q14790_
CASP8 Caspase-8
K.VFFIQAC*QGDNYQK.G
326


C360








Q15149_
PLEC Plectin
K.YLTC*PK.T
327


C4574








Q9UJY4_
GGA2 ADP-ribosylation factor-
R.NLLDLLSAQPAPC*PLNYVSQK.S
328


C429
binding protein GGA2







Q15306_
IRF4 Interferon regulatory factor 4
R.DYVPDQPHPEIPYQC*PMTFGPR.G
329


C194








Q6L8Q7_
PDE12 2,5-phosphodiesterase 12
K.SRPNASGGAAC*SGPGPEPAVFCEPVVK.
330


C108

L






Q8TDP1_
RNASEH2C Ribonuclease H2 subunit
R.DAVPATLHLLPC*EVAVDGPAPVGR.F
331


C34
C







Q13045_
FLU Protein flightless-1 homolog
R.TGLC*YLPEELAALQK.L
332


C46








O95881_
TXNDC12 Thioredoxin domain-
K.SWC*GACK.A
333


C66
containing protein 12







Q9Y296_
TRAPPC4 Trafficking protein particle
R.C*ELFDQNLK.L
334


C195
complex subunit 4







Q00765_
REEP5 Receptor expression-
K.NC*MTDLLAK.L
335


C18
enhancing protein 5







Q86X76_
NIT1 Nitrilase homolog 1
K.THLC*DVEIPGQGPMCESNSTMPGPSLES
336


C165

PVSTPAGK.I






P52597_
HNRNPF Heterogeneous nuclear
R.GLPFGC*TK.E
337


C122
ribonucleoprotein F







Q96HE7_
ERO1L ERO1-like protein alpha
R.CFC*QVSGYLDDCTCDVETIDR.F
338


C37








Q9BUH6_
C9orf142 Uncharacterized protein
R.C*PGESLINPGFK.S
339


C180
C9orf142







Q13158_
FADD Protein FADD
R.RVDDFEAGAAAGAAPGEEDLC*AAFNVI
340


C98

CDNVGK.D






Q9UBE0_
SAE1 SUMO-activating enzyme
K.KVVFC*PVK.E
341


C214
subunit 1







Q9P2J5_
LARS Leucine--tRNA ligase,
K.NLETFC*EETR.R
342


C554
cytoplasmic







Q96PU8_
QK1 Protein quaking
K.LMSSLPNFC*GIFNHLER.L
343


C35








Q6XZF7_
DNMBP Dynamin-binding protein
R.SLDQTSPC*PLVLVR.I
344


C691








Q9Y4R8_
TELO2 Telomere length regulation
R.MDILDVLTLAAQELSRPGC*LGR.T
345


C628
protein TEL2 homolog







Q9HBM1_
SPC25 Kinetochore protein Spc25
K.STDTSC*QMAGLR.D
346


C27








P21980_
TGM2 Protein-glutamine gamma-
K.YGQC*WVFAAVACTVLR.C
347


C277
glutamyltransferase 2







Q9H3U1_
UNC45A Protein unc-45 homolog A
RAIQTVSCLLQGPC*DAGNR.A
348


C426








Q9NRW3_
APOBEC3C Probable DNA dC- dU-
R.LYYFQYPC*YQEGLR.S
349


C130
editing enzyme APOBEC-3C







P55265_
ADAR Double-stranded RNA-specific
K.NFYLC*PV
350


C1224
adenosine deaminase







P48735_
IDH2 Isocitrate dehydrogenase
K.SSGGFVWAC*K.N
351


C308








O60664_
PLIN3 Perilipin-3
R.VASMPLISSTC*DMVSAAYASTK.E
352


C39








Q9NYL9_
TMOD3 Tropomodulin-3
K.FC*NIMGSSNGVDQEHFSNVVK.G
353


C150








Q9HCC0_
MCCC2 Methylcrotonoyl-CoA
K.NIAQIAVVMGSC*TAGGAYVPAMADENII
354


C216
carboxylase beta chain, mitochondrial
VR.K






Q16831_
UPP1 Uridine phosphorylase 1
R.IGTSGGIGLEYGTVVITEQAVDTC*FK.A
355


C162








O00244_
ATOX1 Copper transport protein
K.HEFSVDMTC*GGCAEAVSR.V
356


C12
ATOX1







P11216_
PYGB Glycogen phosphorylase, brain
R.TC*FEIFPDK.V
357


C326
form







P42166_
TMPO Lamina-associated polypeptide
R.NLFISC*K.S
358


C280
2, isoform alpha







O15372_
EIF3H Eukaryotic translation
R.MDSLLIAGQINTYC*QNIK.E
359


C327
initiation factor 3 subunit







Q9BRP1_
PDCD2L Programmed cell death
R.LLHVFACAC*PGCSTGGAR.S
360


C82
protein 2-like







Q15021_
NCAPD2 Condensin complex subunit
K.VACC*PLER.C
361


C767
1







P30042_
C21orf33 ES1 protein homolog,
K.EFHQAGKPIGLCC*IAPVLAAK.V
362


C177
mitochondrial







Q13425_
SNTB2 Beta-2-syntrophin
R.LVHSGSGC*R.S
363


C391








O00159_
MYO1C Unconventional myosin-1c
R.C*PENAFFLDHVR.T
364


C802








O95071_
UBR5 E3 ubiquitin-protein ligase
R.C*ATTPMAVHR.V
365


C2267
UBR5







Q02809_
PLOD1 Procollagen-lysine,2-
R.VGVDYEGGGC*R.F
366


C680
oxoglutarate 5-dioxygenase 1







Q96RE7_
NACC1 Nucleus accumbens-
R.NTLANSC*GTGHLS
367


C416
associated protein 1







Q9UPQ0_
LIMCH1 LIM and calponin homology
K.AANSC*TSYSGTTLNLKEFEGLLAQMR.K
368


C140
domains-containing protein 1







O14776_
TCERG1 Transcription elongation
R.YLVLDC*VPEER.R
369


C1062
regulator 1







Q9H410_
DSN1 Kinetochore-associated protein
K.VFDC*MELVMDELQGSVK.Q
370


C287
DSNI homolog







Q12959_
DLG1 Disks large homolog 1
K.LLAVNNVC*LEEVTHEEAVTALK.N
371


C378








Q86UV5_
USP48 Ubiquitin carboxyl-terminal
R.IWLEPC*IR.G
372


C39
hydrolase 48







P50454_
SERPINH1 Serpin H1
K.QHYNC*EHSK.I
373


C156








Q99798_
ACO2 Aconitate hydratase,
R.DLGGIVLANACGPC*IGQWDR.K
374


C451
mitochondrial







Q9P2T1_
GMPR2 GMP reductase 2
K.VGIGPGSVC*TTR.K
375


C186








Q9BTW9
TBCD Tubulin-specific chaperone D
K.AGAPDEAVCGENVSQIYC*ALLGCMODY
376


C850

TTDSR.G






Q8NFH5_
NUP35 Nucleoporin NUP53
R.C*ALSSPSLAFTPPIK.T
377


C255








P32322_
PYCR1 Pyrroline-5-carboxylate
R.C*MTNTPVVVR.E
378


C120
reductase 1, mitochondrial







P50851_
LRBA Lipopolysaccharide-responsive
R.SLVNIPADGVTVDPALLPPAC*LGALGDL
379


C1704
and beige-like anchor protein
SVEQPVQFR.S






Q9UBR2_
CTSZ Cathepsin Z
K.DQECDKFNQCGTC*NEFK.E
380


C173








Q8IWV8_
UBR2 E3 ubiquitin-protein ligase
R.GNPLHLC*K.E
381


C1717
UBR2







O75369_
FLNB Filamin-B
KIEC*SDNGDGTCSVSYLPTKPGEYFVNILF
382


C1087

EEVHIPGSPFK.A






Q9Y4P1_
ATG4B Cysteine protease ATG4B
K.NFPAIGGTGPTSDTGWGC*MLR.C
383


C74








Q8TD19_
NEK9 Serine/threonine-protein kinase
R.LLTFGC*NK.C
384


C623
Nek9







Q9UMSO_
NFU1 NFU1 iron-sulfur cluster
K.LQGSCTSC*PSSITILK.N
385


C213
scaffold homolog, mitochondrial







O94953_
KDM4B Lysine-specific demethylase
R.TEPYCAICTLFYPYC*QALQTEK.E
386


C694
4B







QI5149_
PLEC Plectin
K.VLSSSGSEAAVPSVC*FLVPPPNQEAQEA
387


C992

VTR.L






P14735_
IDE Insulin-degrading enzyme
R.EMDSCPVVGEFPC*QNDINLSQAPALPQP
388


C974

EVIQNMTEFKR.G






Q9NVG8_
TBC1D13 TBC1 domain family
K.SLDDSQC*GITYK.M
389


C282
member 13







Q86TI2_
DPP9 Dipeptidyl peptidase 9
R.C*PESGEHYEVTLLHFLQEYL
390


C844








O94992_
HEXIM1 Protein HEXIM1
R.AFPQLGGRPGPEGEGSLESQPPPLQTQAC
391


C84

PESSC*LR.E






Q86YH6_
PDSS2 Decaprenyl-diphosphate
R.C*LLSDELSNIAMQVRX
392


C71
synthase subunit 2







P19447_
ERCC3 TFIIH basal transcription
R.SGVIVLPC*GAGK.S
393


C342
factor complex helicase







Q9Y3D2_
MSRB2 Methionine-R-sulfoxide
K.YC*SGTGWPSFSEAHGTSGSDESHTGILR.
394


C105
reductase B2, mitochondrial
R






Q9P253_
VPS18 Vacuolar protein sorting-
R.SAVLQPGC*PSVGIPHSGYVNAQLEK.E
395


C22
associated protein 18 homolog







O75150_
RNF40 E3 ubiquitin-protein ligase
R.EIQPC*LAESR.A
396


C890
BREIB







P04818_
TYMS Thymidylate synthase
R.DLPLMALPPCHALC*QFYVVNSELSCQLY
397


C199

QR.S






Q00535_
CDK5 Cyclin-dependent kinase 5
R.C*YSAEVVTLWYRPPDVLFGAK.L
398


C157








Q96N67_
DOCK7 Dedicator of cytokinesis
K.AVLPVTC*HR.D
399


C2125
protein 7







O95340_
PAPSS2 Bifunctional 3-
R.VWGTTC*TK.H
400


C350
phosphoadenosine 5-phosphosu1fate







Q96F86_
EDC3 Enhancer of mRNA-decapping
R.IYLCDIGIPQQVFQEVGINYHSPFGC*K.F
401


C499
protein 3







Q6QNY0_
BLOC1S3 Biogenesis of lysosome-
R.GDLC*ALAER.L
402


C168
related organelles complex







Q7Z3B4_
NUP54 Nucleoporin p54
K.AVGYSC*MPSNICDEDGLVVLVFNK.K
403


C180








Q9UPT9_
USP22 Ubiquitin carboxyl-terminal
R.KITSNC*TIGLR.G
404


C171
hydrolase 22







P45954_
ACADSB Short/branched chain
K.VGSFC*LSEAGAGSDSFALK.T
405


C175
specific acyl-CoA dehydrogenase







Q9UKT9_
IKZF3 Zinc fmger protein Aiolos
R.SYELLKPPPIC*PR.D
406


C434








Q9NR50_
EIF2B3 Translation initiation factor
K.EANTLNLAPYDAC*WNACR.G
407


C281
eIF-2B subunit gamma







Q9HB90_
RRAGC Ras-related GTP-binding
R.SC*GHQTSASSLK.A
408


C377
protein C







Q5T0N5_
FNBP1L Formin-binding protein 1-
R.FTSC*VAFFNILNELNDYAGQR.E
409


C69
like







P07339_
CTSD Cathepsin D
K.LLDIAC*WIHHK.Y
410


C117








Q7Z6Z7_
HUWE1 E3 ubiquitin-protein ligase
K.AC*SPCSSQSSSSGICTDFWDLLVK.L
411


C3372
HUWE1







O00267_
SUPT5H Transcription elongation
R.SFAFLHC*K.K
412


C626
factor SPT5







O95347_
SMC2 Structural maintenance of
R.FTQC*QNGK.I
413


C1174
chromosomes protein 2







Q92616_
GCN1L1 Translational activator
R.VLQEALC*VISGVPGLK.G
414


C648
GCN1







P85037_
FOXK1 Forkhead box protein K1
R.SMVSPVPSPTGTISVPNSC*PASPR.G
415


C254








P17655_
CAPN2 Calpain-2 catalytic subunit
K.MPC*QLHQVIVAR.F
416


C640








P50851_
LRBA Lipopolysaccharide-responsive
K.C*SGIGDNPGSETAAPR.A
417


C2675
and beige-like anchor protein







O14733_
MAP2K7 Dual specificity mitogen-
R.YQAEINDLENLGEMGSGTC*GQVWK.M
418


C131
activated protein kinase







A6NED2_
RCCD1 RCC1 domain-containing
R.GEPLWAQNVVPEAEGEDDPAGEAQAGR
419


C139
protein 1
LPLLPC*AR.A






Q14980_
NUMA1 Nuclear mitotic apparatus
R.QFC*STQAALQAMER.E
420


C961
protein 1







Q9NYL2_
MLTK Mitogen-activated protein
K.FDDLQFFENC*GGGSFGSVYR.A
421


C22
kinase kinase kinase MLT







Q13867_
BLMH Bleomycin hydrolase
R.C*WIFSCLNVMR.L
422


C73








Q9BRJ7_
NUDT16L1 Protein syndesmos
R.VLGLGLGC*LR.L
423


C88








Q96P48_
ARAP1 Arf-GAP with Rho-GAP
R.AVFPEGPC*EEPLQLR.K
424


C900
domain, ANK repeat and PH domain





1







Q5MNZ6_
WDR45L WD repeat domain
R.C*NYLALVGGGK.K
425


C63
phosphoinositide-interacting protein 3







Q13588_
GRAP GRB2-related adapter protein
K.SPGAC*FAQAQFDFSAQDPSQLSFR.R
426


C161








H0Y2S0_
Uncharacterized protein
R.YTQQGFGNLPIC*MAK.T
427


C31








Q9ULW0_
TPX2 Targeting protein for Xklp2
R.TVEIC*PFSFDSR.D
428


C536








Q9HAV4_
XPO5 Exportin-5
K.C*ALMEALVLISNQFK.N
429


C646








Q5T1V6_
DDX59 Probable ATP-dependent
DDX59 K.NLPC*ANVR.Q
430


C414
RNA helicase DDX59







O14181_
POLA2 DNA polymerase alpha
K.VLGC*PEALTGSYK.S
431


C198
subunit B







Q8LZ73_
RPUSD2 RNA pseudouridylate
R.LLAENEDVVVVDKPSSIPVHPC*GR.F
432


C246
synthase domain-containing protein 2







Q86UP2_
KTN1 Kinectin
K.TMMFSEDEALC*VVDLLK.E
433


C303








Q9UGP4_
LIMD1 LIM domain-containing
R.TPSVSAPLALSC*PR.Q
434


C305
protein 1







P32929_
CTH Cystathionine gamma-lyase
K.YMNGHSDVVMGLVSVNC*ESLHNR.L
435


C229








Q7Z6Z7_
HUWE1 E3 ubiquitin-protein ligase
R.HMLLLAIQEC*SEGFGLA.-
436


C4367
HUWE1







P31153_
MAT2A S-adenosylmethionine
R.VHTIVISVQHDEEVC*LDEMR.D
437


C214
synthase isoform type-2







Q96NY7_
CLIC6 Chloride intracellular channel
R.AGYDGESIGNC*PFSQR.L
438


C487
protein 6







P14635_
CCNB1 G2/mitotic-specific cyclin-B1
R.FMQNNC*VPK.K
439


C238








Q13303_
KCNAB2 Voltage-gated potassium
R.EKVEVQLPELFHKIGVGAMTWSPLAC*GI
440


C248
channel subunit beta-2
VSGKYDSGIPPYSR.A






Q9HAV4_
XPO5 Exportin-5
K.C*PICVPCGLR.L
441


C44








Q8ND24_
RNF214 RING finger protein 214
R.SSHAPATC*K.L
442


C655








Q9HB90_
RRAGC Ras-related GTP-binding
R.KGLIDYNFHC*FR.K
443


C358
protein C







Q92878_
RAD50 DNA repair protein RAD50
K.NIDQC*SEIVK.C
444


C1296








Q14149_
MORC3 MORC family CW-type zinc
R.LSALC*PK.F
445


C15
finger protein 3







P13798_
APEH Acylamino-acid-releasing
R.NPVINIASMLGSTDIPDWCVVEAGFPFSS
446


C641
enzyme
DC*LPDLSVWAEMLDK.S






Q01813_
PFKP 6-phosphofructokinase type C
K.HEEFCVPMVMVPATVSNNVPGSDFSIGA
447


C563

DTALNTITDTC*DRIK.Q






Q96T76_
MMS19 MMS19 nucleotide excision
R.VGESNLTNGDEPTQC*SR.H
448


C549
repair protein homolog







Q9BTE6_
AARSD1 Alanyl-tRNA editing
R.VVNIEGVDSNMC*CGTHVSNLSDLQVIK.I
449


C209
protein Aarsd1







Q9C011_
MTMR12 Myotubularin-related
R.HHSQQAPQAEAPC*LLR.N
450


C694
protein 12







P32320_
CDA Cytidine deaminase
K.RPACTLKPEC*VQQLLVCSQEAK.K
451


C14








Q9P2E9_
RRBP1 Ribosome-binding protein 1
K.LTAEFEEAQTSAC.R.L
452


C1323








P30876_
POLR2B DNA-directed RNA
R.DC*QIAHGAAQFLR.E
453


C1093
polymerase H subunit RPB2







P07237_
P4HB Protein disulfide-isomerase
K.YLLVEFYAPWC*GHCK.A
454


C53








Q8IZ73_
RPUSD2 RNA pseudouridylate
K.QSLDVLDLC*EGDLSPGLTDSTAPSSELG
455


C431
synthase domain-containing protein 2
KDDLEELAAAAQK.M






Q6NZY4_
ZCCHC8 Zinc finger CCHC domain-
R.IFGSIPMQAC*QQK.D
456


C393
containing protein 8







Q96EB1_
ELP4 Elongator complex protein 4
K.VEPC*SLTPGYTK.L
457


C218








O60568_
PLOD3 Procollagen-lysine,2-
K.GLDYEGGGC*R.F
458


C691
oxoglutarate 5-dioxygenase 3







Q8WV74_
NUDT8 Nucleoside diphosphate-
R.LAGLTC*SGAEGLARPK.Q
459


C207
linked moiety X motif 8,





mitochondrial







Q7Z6Z7_
HUWE1 E3 ubiquitin-protein ligase
R.STDRLPSAHTC*FNQLDLPAYESFEK.L
460


C4341
HUWE1







P16455_
MGMT Methylated-DNA--protein-
R.GNPVPILIPC*HR.V
461


C145
cysteine methyltransferase







Q86X76_
NIT1 Nitrilase homolog 1
K.IGLAVC*YDMR.F
462


C203








Q9BR61_
ACBD6 Acyl-CoA-binding domain-
R.DQDGCLPEEVTGC*K.T
463


C267
containing protein 6







Q8IU81_
IRF2BP1 Interferon regulatory factor
R.EPAPAEALPQQYPEPAPAALC*GPPPRAP
464


C363
2-binding protein 1
SR.N






Q9Y5T5_
USP16 Ubiquitin carboxyl-terminal
K.GLSNLGNTC*FFNAVMQNLSQTPVLR.E
465


C205
hydrolase 16







Q8IWZ3_
ANKHD1 Ankyrin repeat and KH
R.AGHLC*TVQFLISK.G
466


C615
domain-containing protein 1







Q13158_
FADD Protein FADD
R.RVDDFEAGAAAGAAPGEEDLCAAFNVIC
467


C105

*DNVGKDWRR.L






P29590_
PML Protein PML
R.GCSKPLCC*SCALLDSSHSELK.C
468


C213








Q00653_
NFKB2 Nuclear factor NF-kappa-B
R.YGC*EGPSHGGLPGASSEK.G
469


C57
p100 subunit







Q9BVA1_
TUBB2B Tubulin beta-2B chain
K.ESESCDC*LQGFQLTHSLGGGTGSGMGT
470


C129

LLISK.I






Q9NZA1_
CLIC5 Chloride intracellular channel
K.AGIDGESIGNC*PFSQR.L
471


C191
protein 5







O60551_
NMT2 Glycylpeptide N-
R.AMELLSAC*QGPAR.N
472


C104
tetradecanoyltransferase 2







Q16667_
CDKN3 Cyclin-dependent kinase
R.VNC*SQFLGLCALPGCK.F
473


C39
inhibitor 3







A3KN83_
SBNO1 Protein strawberry notch
K.NLC*PVGSSKPTK.T
474


C445
homolog 1







Q8N999_
C12orf29 Uncharacterized protein
K.C*LFNHFLK.I
475


C302
C12orf29







Q6YN16_
HSDL2 Hydroxysteroid
K.QHC*AYTIAK.Y
476


C166
dehydrogenase-like protein 2







Q9HB19_
PLEKHA2 Pleckstrin homology
R.SISLTRPGSSSLSSGPNSILC*R.G
477


C332
domain-containing family A member





2







Q8WVV9_
HNRPLL Heterogeneous nuclear
K.NIIQPPSCVLHYYNVPLC*VTEETFTK.L
478


C464
ribonucleoprotein L-like







O75175_
CNOT3 CCR4-NOT transcription
R.DIILSSTSAPPASAQPPLQLSEVNIPLSLGV
479


C600
complex subunit 3
C*PLGPVPLTK.E






Q7L2J0_
MEPCE 7SK snRNA
K.FQYGNYC*K.Y
480


C419
methylphosphate capping enzyme







P36405_
ARL3 ADP-ribosylation factor-like
R.VWQIQSCSALTGEGVQDGMNWVC*K.N
481


C174
protein 3







Q9Y4X0_
AMMECR1 AMME syndrome
R.GC*IGTFSAMNLHSGLR.E
482


C175
candidate gene 1 protein







Q9NZB2_
FAM120A Constitutive coactivator of
K.GSQMGTVQPIPC*LLSMPTR.N
483


C531
PPAR-gamma-like protein







P26358_
DNMT1 DNA (cytosine-5)-
R.GVCSC*VEAGK.A
484


C1478
methyltransferase 1







Q8TB03_
CXorf38 Uncharacterized protein
R.LNC*AEYK.N
485


C12
CXorf38







Q9Y676_
MRPS18B 28S ribosomal protein
K.LLEQFVC*AHTGIIFYAPYTGVCVK.Q
486


C128
S18b, mitochondrial







Q9Y613_
FHOD1 FH1/FH2 domain-containing
R.TPQSPAPC*VLLR.A
487


C502
protein 1







Q99986_
VRK1 Serine/threonine-protein kinase
K.VGLPIGQGGFGC*IYLADMNSSESVGSDA
488


C50
VRK1
PCVVK.V






P53992_
SEC24C Protein transport protein
R.APPSSGAPPASTAQAPC*GQAAYGQFGQ
489


C78
Sec24C
GDVQNGPSSTVQMQR.L






Q96RN5_
MED15 Mediator of RNA polymerase
R.TFVPAMTAIHGPPITAPVVC*TR.K
490


C660
II transcription subunit







Q27J81_
INF2 Inverted formin-2
R.AVLLASDAQEC*TLEEVVER.L
491


C332








Q27J81_
INF2 Inverted formin-2
K.QEEVC*VIDALLADIR.K
492


C971








Q9UBB4_
ATXN10 Ataxin-10
K.ETTNIFSNCGC*VR.A
493


C356








Q08378_
GOLGA3 Golgin subfamily A
K.GEASSSNPATPIKIPDC*PVPASLLEELLRP
494


C1403
member 3
PPAVSKEPLK.N






Q8WWI1_
LMO7 LIM domain only protein 7
R.DSGYGDIWC*PER.G
495


C228








P10398_
ARAF Serine/threonine-protein kinase
R.TQADELPAC*LLSAAR.L
496


C597
A-Raf







Q9NZ32_
ACTR10 Actin-related protein 10
R.IPDWC*SLNNPPLEMMFDVGK.T
497


C388








Q9Y2X3_
NOP58 Nucleolar protein 58
K.LNLSC*IHSPVVNELMR.G
498


C106








P53396_
ACLY ATP-citrate synthase
R.LTKPIVCWCIGTCATMFSSEVQFGHAGAC
499


C764

*ANQASETAVAK.N






P18124_
RPL7 60S ribosomal protein L7
K.YGIIC*MEDLIHENTVGK.R
500


C186








Q9BUK6_
MST01 Protein misato homolog 1
R.VAPPYPHLFSSC*SPPGMVLDGSPK.G
501


C485








O00541_
PES1 Pescadillo homolog
K.AGEGTYALDSESC*MEK.L
502


C272








Q9Y277_
VDAC3 Voltage-dependent anion-
K.VC*NYGLTFTQK.W
503


C65
selective channel protein







Q02556_
IRF8 Interferon regulatory factor 8
R.VFCSGNAVVC*K.G
504


C306








Q01082_
SPTBN1 Spectrin beta chain, non-
R.IHC*LENVDK.A
505


C112
erythrocytic 1







A2A288_
ZC3H12D Probable ribonuclease
R.LAFSDDLGPLGPPLPVPAC*SLTPR.L
506


C367
ZC3H12D







O14936_
CASK Peripheral plasma membrane
R.HLEEAVELVC*TAPQWVPVSWVY
507


C914
protein CASK







O43290_
SART1 U4/U6.U5 tri-snRNP-
R.GLAAALLLC*QNK.G
508


C645
associated protein 1







Q9UBV8_
PEF1 Peflin
K.QALVNC*NWSSFNDETCLMMINMFDK.T
509


C146








Q6PCB5_
RSBN1L Round spermatid basic
K.SIQTIC*SGLLTDVEDQAAK.G
510


C280
protein 1-like protein







Q08380_
LGALS3BP Galectin-3-binding
K.STSSFPC*PAGHFNGFR.T
511


C561
protein







P57737_
CORO7 Coronin-7
R.AGTAPSC*R.N
512


C34








Q92616_
GCNIL1 Translational activator
R.C*GLALALNK.L
513


C1235
GCN1







P24468_
NR2F2 COUP transcription factor 2
K.AIVLFTSDAC*GLSDVAHVESLQEK.S
514


C326








Q96RP9_
GFM1 Elongation factor G,
R.VLDGAVLVLCAVGGVQC*QTMTVNR.Q
515


C153
mitochondrial







Q9NRF9_
POLE3 DNA polymerase epsilon
R.AASVFVLYATSC*ANNFAMK.G
516


C51
subunit 3







P30837_
ALDH1B1 Aldehyde dehydrogenase
R.HEPVGVC*GQIIPWNFPLVMQGWK.L
517


C179
X, mitochondrial







Q8WUM4_
PDCD6IP Programmed cell death 6-
K.FPFSENQIC*LTFTWK.D
518


C90
interacting protein







Q9NP73_
ALG13 UDP-N-acetylglucosamine
K.ADLVISHAGAGSC*LETLEK.G
519


C86
transferase subunit ALG13







P13667_
PDIA4 Protein disulfide-isomerase A4
K.EENGVLVLNDANFDNFVADKDTVLLEFY
520


C91

APWC*GHCK.Q






P09884_
POLA1 DNA polymerase alpha
R.YIFDAEC*ALEK.L
521


C1403
catalytic subunit







O95833_
CLIC3 Chloride intracellular channel
K.ASEDGESVGHC*PSCQR.L
522


C22
protein 3







Q9NTX5_
ECHDC1 Ethylmalonyl-CoA
K.SLGTPEDGMAVC*MFMQNTLTR.F
523


C133
decarboxylase







Q14289_
PTK2B Protein-tyrosine kinase 2-beta
K.NELC*QLPPEGYVVVVK.N
524


C899








P49792_
RANBP2 E3 SUMO-protein ligase
K.MIC*QQVEAIKKE
525


C815
RanBP2







Q14137_
BOP1 Ribosome biogenesis protein
R.DLQPFPTC*QALVYR.G
526


C404
BOP1







Q15345_
LRRC41 Leucine-rich repeat-
R.C*AAALMASR.R
527


C297
containing protein 41







Q99538_
LGMN Legiunain
R.ESSYAC*YYDEK.R
528


C219








Q96EK4_
THAP11 THAP domain-containing
R.AGVSGC*FSTFQPTTGHR.L
529


C48
protein 11







O60488_
ACSL4 Long-chain-fatty-acid--CoA
K.GYDAPLC*NLLLFK.K
530


C420
ligase 4







Q96EY5_
FAM125A Multivesicular body
K.SC*SPLAFSAFGDLTIK.S
531


C231
subunit 12A







P22307_
SCP2 Non-specific lipid-transfer
K.SGLTPNDEDVIELHDC*FSTNELLTYEALG
532


C307
protein
LCPEGQGATLVDR.G






Q969Z0_
TBRG4 Protein TBRG4
R.LATDLLSLMPSLTSGEVAHC*AK.S
533


C335








P46734_
MAP2K3 Dual specificity mitogen-
R.ISC*MSKPPAPNPTPPR.N
534


C29
activated protein kinase







Q5JPI3_
C3orf38 Uncharacterized protein
K.FEQSDLEAFYNVITVC*GTNEVR.H
535


C308
C3orf38







Q9NRA8_
EIF4ENIF1 Eukaryotic translation
R.DAVLPEQSPGDFDFNEFFNLDKVPC*LAS
536


C318
initiation factor 4E transporter
MIEDVLGEGSVSASR.F






Q15648_
MED1 Mediator of RNA polymerase
K.VAHHGENPVSC*PELVQQLR.E
537


C135
II transcription subunit







Q8IZ69_
TRMT2A tRNA (uracil-5-)-
R.VIGVELC*PEAVEDAR.V
538


C463
methyltransferase homolog A







Q04206_
RELA Transcription factor p65
R.YKC*EGR.S
539


C38








O15533_
TAPBP Tapasin
K.WASGLTPAQNC*PR.A
540


C115








Q9UNI6_
DUSP12 Dual specificity protein
R.VSC*AGQMLEVQPGLYEGGAAAVAEPD
541


C23
phosphatase 12
HLR.E






Q9BUP3_
HTATIP2 Oxidoreductase HTATIP2
R.YSVFRPGVLLC*DR.Q
542


C172








P53384_
NUBP1 Cytosolic Fe-S cluster
K.LPIIGVVENMSGFIC*PK.C
543


C235
assembly factor NUBP1







Q7Z5K2_
WAPAL Wings apart-like protein
R.LENINEAIEEDIVQSVLRPTNC*R.T
544


C293
homolog







Q9Y5S2_
CDC42BPB Serine/threonine-protein
R.IRPLNSEGTLNLLNC*EPPR.L
545


C1517
kinase MRCK beta







Q15024_
EXOSC7 Exosome complex
K.GVVTC*MR.K
546


C238
component RRP42







P40855_
PEX19 Permdsomal biogenesis factor
R.VGSDMTSQQEFTSC*LK.E
547


C128
19







Q15910_
EZH2 Histone-lysine N-
R.LWAAHC*R.K
548


C503
methyltransferase EZH2







Q15149_
PLEC Plectin
K.FLEGTSC*IAGVFVDATK.E
549


C4071








P22307_
SCP2 Non-specific lipid-transfer
R.AIYHSLGMTGIPIINVNNNC*ATGSTALFM
550


C94
protein
AR.Q






Q12789_
GTF3C1 General transcription factor
R.VPPFPLPLEPC*TQEFLWR.A
551


C42
3C polypeptide 1







Q15796_
SMAD2 Mothers against
K.CVTIPSTC*SEIWGLSTPNTIDQWDTTGLY
552


C81
decapentaplegic homolog 2
SFSEQTR.S






Q9UL15_
BAGS BAG family molecular
K.TELQGLIGQLDEVSLEICNPC*IR.E
553


C327
chaperone regulator 5







Q8N9T8_
KRI1 Protein KRI1 homolog
R.LLGPTVMLGGC*EFSR.Q
554


C673








Q9Y679_
AUP1 Ancient ubiquitous protein 1
K.TGC*VDLTTTNLLEGAVAFMPEDITK.G
555


C391








O14733_
MAP2K7 Dual specificity mitogen-
K.LC*DFGISGR.L
556


C260
activated protein kinase







O75179_
ANKRD17 Ankyrin repeat domain-
R.AGHVC*TVQFLISK.G
557


C644
containing protein 17







P31323_
PRKAR2B cAMP-dependent protein
R.LLGPC*MEINK.R
558


C388
kinase type II-beta regulatory subunit







Q9HBL8_
NMRAL1 NmrA-like family domain-
R.LPC*YFENLLSHFLPQK.A
559


C154
containing protein 1







Q96RU2_
USP28 Ubiquitin carboxyl-terminal
K.NVGNTC*WFSAVIQSLFQLPEFR.R
560


C171
hydrolase 28







Q96T76_
MMS19 MMS19 nucleotide excision
R.ELLELSCCHSC*PFSSTAAAK.C
561


C750
repair protein homolog







P17858_
PFKL 6-phosphofructokinase, liver
R.C*KAFTTR.E
562


C89
type







Q96F07_
CYFIP2 Cytoplasmic FMR1-
R.LCC*GLSMFEVILTR.I
563


C1112
interacting protein 2







P42695_
NCAPD3 Condensin-2 complex
R.C*VMAMLR.R
564


C541
subunit D3







Q9Y2S7_
POLDIP2 Polymerase delta-
R.DC*PHISQR.S
565


C143
interacting protein 2







P52948_
NUP98 Nuclear pore complex protein
R.WLSC*TATPQIEEEVSLTQK.N
566


C1312
Nup98-Nup96







Q9UER7_
DAXX Death domain-associated
K.IC*TLPSPPSPLASLAPVADSSTR.V
567


C664
protein 6







Q9H4L7_
SMARCAD1 SWI/SNF-related
K.NTEMC*NVMMQLR.K
568


C772
matrix-associated actin-dependent







Q9Y570_
PPME1 Protein phosphatase
R.FAEPIGGFQC*VFPGC
569


C381
methylesterase 1







P52701_
MSH6 DNA mismatch repair protein
K.TFFGDDFIPNDILIGC*EEEEQENGK.A
570


C1117
Msh6







P33992_
MCM5 DNA replication licensing
R.C*SVLAAANSVFGR.W
571


C482
factor MCM5







E2QRD5_
C15orf38-AP3S2 Protein C15orf38-
K.C*NFTGDGK.T
572


C183
AP3S2







Q16877_
PFKFB4 6-phosphofructo-2-
K.TFFVESIC*VDPEVIAANIVQVK.L
573


C159
kinase/fructose-2,6-bisphosphatase 4







Q9BSQ5_
CCM2 Malcavernin
K.VAAEELCC*LLGQVFQVVYTESTIDFLDR.
574


C211

A






Q00013_
MPP1 55 kDa erythrocyte membrane
K.K.DNLIPC*K.E
575


C179
protein







Q6UWP2_
DHRS11 Dehydrogenase/reductase
K.C*LKPEDVAEAVIYVLSTPAHIQIGDIQMR
576


C226
SDR family member 11
PTEQVT






Q8N556_
AFAP1 Actin filament-associated
K.SQAAPGSSPC*R.G
577


C713
protein 1







Q9NXJ5_
PGPEP1 Pyroglutamyl-peptidase 1
R.YLC*DFTYYTSLYQSHGR.S
578


C149








Q8IYS1_
PM20D2 Peptidase M20 domain-
MRPGGERPVEGGAC*NGR.S
579


C14
containing protein 2







Q92878_
RAD50 DNA repair protein RAD50
K.TTIIEC*LK.Y
580


C48








Q68CZ2_
TNS3 Tensin-3
R.SC*PETLTHAVGMSESPIGPK.S
581


C888








O75592_
MYCBP2 Probable E3 ubiquitin-
R.C*SILSPELALPTGSR.A
582


C1131
protein ligase MYCBP2







Q5VUA4_
ZNF318 Zinc finger protein 318
K.LSPQAC*SFTK.A
583


C1860








Q9H3M7_
TXN1P Thioredoxin-interacting
K.VSC*MFIPDGR.V
584


C170
protein







Q92619_
HMHA1 Minor histocompatibility
R.C*EGGVDAALLYAK.N
585


C278
protein HA-1







P46013_
MKI67 Antigen KI-67
K.SEETNTEIVEC*ILK.R
586


C903








Q9UI30_
TRMT112 tRNA methyltransferase
K.GPVEGYEENEEFLRTMHHLLLEVEVIEGT
587


C100
112 homolog
LQC*PESGR.M






Q92797_
SYMPK Symplekin
R.GMGMNSPELLLLVENC*PK.G
588


C848








P50990_
CCT8 T-complex protein 1 subunit
R.NIQAC*K.E
589


C36
theta







O76075_
DFFB DNA fragmentation factor
R.VLGSMC*QR.L
590


C194
subunit beta







P04150_
NR3C1 Glucocorticoid receptor
K.LGTVYC*QASFPGANIIGNK.M
591


C302








Q96JH7_
VCPIP1 Deubiquitinating protein
K.SQECLIPVHVDGDGHC*LVHAVSR.A
592


C219
VCIP135







Q8NEC7_
GSTCD Glutathione S-transferase C-
K.AC*AEVSQWTR.L
593


C140
terminal domain-containing







P48200_
IREB2 Iron-responsive element-
K.C*AIQNAPNPGGGDLQK.A
594


C137
binding protein 2







Q8WTW3_
COG1 Conserved oligomeric Golgi
K.AQAISPC*VQNFCSALDSK.L
595


C513
complex subunit 1







Q9BYX2_
TBC1D2 TBC1 domain family
R.TQNC*FLNSEIHQVTK.I
596


C469
member 2A







P51991_
HNRNPA3 Heterogeneous nuclear
R.GFGFVTYSC*VEEVDAAMCAR.P
597


C85
ribonucleoprotein A3







Q5UIP0_
RIF1 Telomere-associated protein
K.ESIPCPTESVYPPLVNC*VAPVDIILPQITS
598


C2298
RIF1
NMWAR.G






Q5T440_
IBA57 Putative transferase CAF17,
R.VWAVLPSSPEAC*GAASLQER.A
599


C170
mitochondrial







P46821_
MAP 1B Microtubule-associated
R.KSC*FWK.L
600


C293
protein 1B







Q9BT09_
CNPY3 Protein canopy homolog 3
K.QC*DVLVEEFEEVIEDWYR.N
601


C166








Q8IXB1_
DNAJC10 DnaJ homolog subfamily C
K.ESVNSHVTTLGPQNFPANDKEPWLVDFF
602


C480
member 10
APWC*PPCR.A






O00622_
CYR61 Protein CYR61
K.C*APGVGLVR.D
603


C39








Q69YN2_
CWF19L1 CWF19-like protein 1
K.QILAPVEESAC*QFFFDLNEK.Q
604


C288








Q8TEX9_
IPO4 Importin-4
K.LLEC*PHLNVR.K
605


C708








Q9Y6W3_
CAPN7 Calpain-7
R.AHFPLGANPFLERPQSFISPQSC*DAQGQR.
606


C197

Y






Q9Y6Y8_
SEC23IP SEC23-interacting protein
K.C*PGPLAVANGVVK.Q
607


C604








Q9ULX6_
AKAP8L A-kinase anchor protein 8-
R.GQC*MSGASR.L
608


C211
like







Q13630_
TSTA3 GDP-L-fucose synthase
K.VVSCLSTC*IFPDK.T
609


C116








P13667_
PDIA4 Protein disulfide-isomerase A4
K.DTVLLEFYAPWCGHC*K.Q
610


C94








Q5T1V6_
DDX59 Probable ATP-dependent
K.LFKPPVLVFVDC*K.L
611


C453
RNA helicase DDX59







Q9GZR2_
REXO4 RNA exonuclease 4
K.ILGLQVQQAEHC*SIQDAQAAMR.L
612


C382








Q8WXD5_
GEMIN6 Gem-associated protein 6
K.LMHLFTSGDC*K.A
613


C91








Q15118_
PDK1
K.QFLDFGSVNAC*EK.T
614


C71








Q8WXE1_
ATRIP ATR-interacting protein
RFQC*VFQVLPKC
615


C585








Q8N2W9_
PIAS4 E3 SUMO-protein ligase
R.VSLIC*PLVK.M
616


C326
PIAS4







Q14141_
SEPT6 Septin-6
R.QYPWGTVQVENEAHC*DFVK.L
617


C269








P26358_
DNMT1 DNA (cytosine-5)-
R.CTVEYGEDLPEC*VQVYSMGGPNR.F
618


C1071
methyltransferase 1







Q8IYQ7_
THNSL1 Threonine synthase-like 1
R.LGEMIETAYGENFAC*SK.I
619


C324








P49419_
ALDH7A1 Alpha-aminoadipic
R.STC*TINYSK.D
620


C522
semialdehyde dehydrogenase







Q9ULJ3_
ZNF295 Zinc finger protein 295
K.TPQAPFPTC*PNR.K
621


C129








Q9HB19_
PLEKHA2 Pleckstrin homology
K.C*EQDREPLR.T
622


C232
domain-containing family A member





2







O76031_
CLPX ATP-dependent Clp protease
K.C*ELNVTEDALK.A
623


C538
ATP-binding subunit clp







Q01581_
HMGCS1 Hydroxymethylglutaryl-
K.TNLMQLFEESGNTDIEGIDTTNAC*YGGT
624


C129
CoA synthase, cytoplasmic
AAVFNAVNWIESSSWDGR.Y






Q96RS6_
NUDCD1 NudC domain-containing
R.LMHLTSEELNPNPDKEKPPC*NAQELEEC
625


C402
protein 1
DIFFEESSSLCR.F






Q9UL45_
PLDN Pallidin
K.FKEC*HSMLDINALFAEAK.H
626


C95








Q9HAU4_
SMURF2 E3 ubiquitin-protein ligase
R.LFTIHQIDAC*TNNLPK.A
627


C706
SMURF2







Q8TCG1_
KIAA1524 Protein CIP2A
K.C*LEPTVALLR.W
628


C337








Q9P0K7_
RAI14 Ankycorbin
K.QILTMC*K.N
629


C973








Q7Z2Z2_
EFTUD1 Elongation factor Tu GTP-
R.ICDGCIIVVDAVEGVC*PQTQAVLR.Q
630


C124
binding domain-containing protein 1







Q5JTD0_
TJAP1 Tight junction-associated
R.NSPLPNC*TYATR.Q
631


C350
protein 1







Q15022_
SUZ12 Polycomb protein SUZ12
R.LQLLDGEYEVAMQEMEEC*PISK.K
632


C325








P30837_
ALDH1B1 Aldehyde dehydrogenase
K.SPSIVLADADMEHAVEQCHEALFFNMGQ
633


C320
X, mitochondrial
CCC*AGSR.T






Q9H0L4_
CSTF2T Cleavage stimulation factor
K.LC*VQNSHQEAR.N
634


C150
subunit 2 tau variant







Q03I69_
TNFAIP2 Tumor necrosis factor
K.GLANVFC*VFTK.G
635


C45
alpha-induced protein 2







Q9UBB4_
ATXN10 Ataxin-10
R.VIHVAGKETTNIFSNC*GCVR.A
636


C354








Q06187_
BTK Tyrosine-protein kinase BTK
K.QRPIFIITEYMANGC*LLNYLR.E
637


C481








Q96N21_
ENTHD2 AP-4 complex accessory
R.ALC*AIASLGSSDLLPQEHILLR.T
638


C302
subunit tepsin







Q92878_
RAD50 DNA repair protein RAD50
R.SMVC*TQK.S
639


C102








Q7Z401_
DENND4A C-myc promoter-binding
R.LKQGC*EIIQSTPYGRPANISGSTSSQR.I
640


C117
protein







Q9H307_
PNN Pinin
RMC*PATQK.L
641


C249








Q96DF8_
DGCR14 Protein DGCR14
R.C*QLQQAAALNAQHK.Q
642


C263








Q7L8W6_
ATPBD4 ATP-binding domain-
K.C*EGDEVEDLYELLK.L
643


C88
containing protein 4







Q13232_
NME3 Nucleoside diphosphate kinase
R.ADELLC*WEDSAGHWLYE
644


C158
3







Q9NWA0_
MED9 Mediator of RNA polymerase
K.SLC*MFEIPKE
645


C139
II transcription subunit







Q9BZ67_
FRMD8 FERM domain-containing
R.VQLGPYQPGRPAAC*DLR.E
646


C191
protein 8







P51617_
IRAK1 Interleulcin-1 receptor-
R.SWHLTPSC*PLDPAPLR.E
647


C608
associated kinase 1







Q9Y4W2_
LAS1L Ribosomal biogenesis protein
K.C*LAQEVNIPDWIVDLR.H
648


C140
LAS1L







Q9NX18_
SDHAF2 Succinate dehydrogenase
R.GMLENC*ILLSLFAK.E
649


C83
assembly factor 2, mitochondrial







Q969H6_
POP5 Ribonuclease P/MRP protein
R.SC*LLEEEEESGEEAAEAME
650


C146
subunit POP5







Q96IV0_
NGLY1 Peptide-N(4)-(N-acetyl-beta-
R.C*GEWANCFTLCCR.A
651


C309
glucosaminyl)asparagin







P42575_
CASP2 Caspase-2
R.SDMICGYAC*LK.G
652


C370








P51812_
RPS6KA3 Ribosomal protein S6
K.EDIGVGSYSVC*K.R
653


C436
kinase alpha-3







P09086_
POU2F2 POU domain, class 2,
R.VWFC*NR.R
654


C346
transcription factor 2







Q8IWV7_
UBR1 E3 ubiquitin-protein ligase
RNSLIELPDDYSC*LLNQASIEFRC
655


C1603
UBR1







Q9H0W8_
SMG9 Protein SMG9
RREDFC*PRK
656


C380








O96017_
CHEK2 Serine/threonine-protein
KTLGSGAC*GEVKL
657


C231
kinase Chk2







Q96RU3_
FNBP1 Formin-binding protein 1
K.KNSKEEEEYKYTSC*K.A
658


C70








O95347_
SMC2 Structural maintenance of
KKNLAC*EESKR
659


C326
chromosomes protein 2







O15357_
INPPL1 Phosphatidylinositol 3,4,5-
RKPAFTEASC*PLSRL
660


C926
trisphosphate 5-phosphatase 2







Q8N5L8_
RPP25L Ribonuclease P protein
R.DPLDPNEC*GYQPPGAPPGLGSMPSSSCG
661


C131
subunit p25-like protein
PR.S






Q9C0I1_
MTMR12 Myotubularin-related
RVFQFC*LRY
662


C152
protein 12







Q96F86_
EDC3 Enhancer of xnRNA-decapping
K.SQDVAVSPQQQQC*SK.S
663


C137
protein 3







O60443_
DFNA5 Non-syndromic hearing
R.FWC*WQRPK.Y
664


C45
impairment protein 5







Q9NU22_
MDN1 Midasin
K.LIC*QHIVPGNVK.S
665


C1011








Q14204_
DYNC1H1 Cytoplasmic dynein 1
K.VWLQYQC*LWDMQAENIYNR.L
666


C1059
heavy chain 1







Q09472_
EP300 Histone acetyltransferase p300
R.C*IQSLVHACQCR.N
667


C1738








P12532_
CKMT1B Creatine kinase U-type,
R.LGYILTC*PSNLGTGLR.A
668


C316
mitochondrial







Q9P2X3_
IMPACT Protein IMPACT
R.STFQAHLAPVVC*PK.Q
669


C195








Q92667_
AKAP1 A-kinase anchor protein 1,
K.SIPLEC*PLSSPK.G
670


C147
mitochondrial







O14879_
IFIT3 Interferon-induced protein with
R.VLESTPNNGYLYHQIGC*CYK.A
671


C283
tetratricopeptide







Q01201_
RELB Transcription factor Relb
R.GAASLSTVTLGPVAPPATPPPWGC*PLGR.
672


C109

L






Q9UPN9_
TRIM33 E3 ubiquitin-protein ligase
R.GNMNC*GAFQAHQMR.L
673


C582
TRIM33







Q9BSD7_
NTPCR Cancer-related nucleoside-
R.VC*VIDEIGK.M
674


C110
triphosphatase







Q8IV53_
DENND1C DENN domain-containing
R.GNSKPLSC*FVAPDSGR.L
675


C174
protein 1C







Q99798_
ACO2 Aconitate hydratase,
R.VGLIGSC*TNSSYEDMGR.S
676


C385
mitochondrial







Q14204_
DYNC1H1 Cytoplasmic dynein 1
R.C*VLNWFGDWSTEALYQVGKEFTSK.M
677


C3089
heavy chain 1







P49903_
SEPHS1 Selenide, water dikinase 1
R.FTELKGTGC*K.V
678


C31








Q7OCQ2_
USP34 Ubiquitin carboxyl-terminal
R.TGDFLGETIGNELFNC*R.Q
679


C741
hydrolase 34







O43439_
CBFA2T2 Protein CBFA2T2
R.FSNGPASSTSSALTNQQLPATC*GAR.Q
680


C111








Q9BWH6_
RPAP1 RNA polymerase II-
R.C*GQGTLLAQACQDLPSIR.N
681


C1039
associated protein 1







Q6AI12_
ANKRD40 Ankyrin repeat domain-
R.TPESTICPGPVC*QPPVSQSR.S
682


C209
containing protein 40







Q5GLZ8_
HERC4 Probable E3 ubiquitin-protein
R.HTVFVLDDGTVYTCGC*NDLGQLGHEK.
683


C60
ligase HERC4
S






Q9Y5A7_
NUB1 NEDD8 ultimate buster 1
R.LECC*ENEVEK.V
684


C52








Q6PJG6_
BRAT1 BRCA1-associated ATM
R.TQAFQVLLQPLAC*VLK.A
685


C326
activator 1







Q6PJG6_
BRAT1 BRCA1-associated ATM
R.THC*PYAVALPEVAPAQPLTEALR.A
686


C673
activator 1







Q8NB90_
SPATA5 Spermatogenesis-associated
K.GVLLYGPPGC*SK.T
687


C672
protein 5







Q9ULT8_
HECTD1 E3 ubiquitin-protein ligase
K.LLQLSC*NGNVK.S
688


C1855
HECTD1







Q9NUI1_
DECR2 Peroxisomal 2,4-dienoyl-CoA
R.HLFC*PDLLR.D
689


C22
reductase







Q9P0V9_
SEPT10 Septin-10
RQYPWGVVQVENENHC*DFVKL
690


C293








Q8WX93_
PALLD Palladin
K.VSSC*EQR.L
691


C964








Q9Y4B4_
RAD54L2 Helicase ARIP4
R.AGC*LGVNLIGANR.V
692


C820








P41226_
UBA7 Ubiquitin-like modifier-
R.APASAAASEDAPYPVC*TVR.Y
693


C599
activating enzyme 7







Q9BZQ6_
EDEM3 ER degradation-enhancing
R.VPC*GFAAMK.D
694


C441
alpha-mannosidase-like 3







P52732_
KIF11 Kinesin-like protein KIF11
R.SVVC*PILDEVIMGYNCTIFAYGQTGTGK.
695


C87

T






P14598_
NCF1 Neutrophil cytosol factor 1
R.C*SESTK.R
696


C378








Q9UL40_
ZNF346 Zinc finger protein 346
K.NQC*LFTNTQCK.V
697


C68








Q9C0C9_
UBE2O Ubiquitin-conjugating
K.NC*AQGEGSMAK.K
698


C375
enzyme E2 O







O14733_
MAP2K7 Dual specificity mitogen-
R.SAGC*AAYMAPER.I
699


C280
activated protein kinase







O95239_
KIF4A Chromosome-associated
R.GLLC*LGNVISALGDDKK.G
700


C269
kinesin KIF4A







Q8WYP5_
AHCTF1 Protein ELYS
R.C*LVAGLLSPR.F
701


C521








Q93074_
MED12 Mediator of RNA polymerase
K.TPQLNPC*QSDGNKPTVGIR.S
702


C1188
II transcription subunit 12







Q16610_
ECM1 Extracellular matrix protein 1
R.AC*PSHQPDISSGLELPFPPGVPTLDNIK.N
703


C284








O00622_
CYR61 Protein CYR61
K.HQCTCIDGAVGCIPLC*PQELSLPNLGCPN
704


C134

PR.L






Q2VPK5_
CTU2 Cytoplasmic tRNA 2-thiolation
R.TPPGPC*CSPGVGWAQR.C
705


C433
protein 2







Q9UI10_
EIF2B4 Translation initiation factor
R.AHNVPVLVCCETYKFC*ER.V
706


C444
eIF-2B subunit delta







Q9UPW5_
AGTPBP1 Cytosolic
RLTSPLEYNLPSSLLDFENDLIESSC*KV
707


C1164
carboxypeptidase 1







Q13613_
MTMR1 Myotubularin-related protein
KDVMYIC*PFMGAVSGTLTVTDFKL
708


C117
I







O00541_
PES1 Pescadillo homolog
K.SLC*IGATYDVTDSR.I
709


C361








P39877_
PLA2G5 Calcium-dependent
K.VTGKNALTNYGFYGC*YCGWGGR.G
710


C46
phospholipase A2







Q14207_
NPAT Protein NPAT
K.SEETTVPFPEESIVPAAKPC*HR.R
711


C1059








P42704_
LRPPRC Leucine-rich PPR motif-
R.AILQENGC*LSDSDMFSQAGLR.S
712


C500
containing protein, mitochondrial







Q9Y5R8_
TRAPPC1 Trafficking protein particle
K.NPLC*PLGQTVQSELFR.S
713


C115
complex subunit 1







O60566_
BUB1B Mitotic checkpoint
K.IPGMTLSSSVCQVNCC*AR.E
714


C504
serine/threonine-protein kinase







Q5T440_
IBA57 Putative transferase CAF17,
K.GC*YIGQELTAR.T
715


C259
mitochondrial







Q5TGY3_
AHDC1 AT-hook DNA-binding
R.GPAAAAAGYGC*PLLSDLTLSPVPR.D
716


C1540
motif-containing protein 1







P43403_
ZAP70 Tyrosine-protein kinase ZAP-
R.PSGLEPQPGVFDC*LR.D
717


C117
70







P07602_
PSAP Proactivator polypeptide
KHC*LQTVWNKPTVK.S
718


C48








Q93074_
MED12 Mediator of RNA polymerase
K.C*QEATAGFTIGR.V
719


C444
II transcription subunit 12







Q96FA3_
PELI1 E3 ubiquitin-protein ligase
R.QEINAARPQC*PVGFNTLAFPSMK.R
720


C282
pellino homolog 1







Q8IY17_
PNPLA6 Neuropathy target esterase
R.LAYVSC*VR.Q
721


C1199








Q8IY18_
SMC5 Structural maintenance of
K.SSIVC*AICLGLAGKPAFMGR.A
722


C91
chromosomes protein 5







Q9NTJ3_
SMC4 Structural maintenance of
R.FSC*IIGPNGSGK.S
723


C110
chromosomes protein 4







Q07065_
CKAP4 Cytoskeleton-associated
K.SSSSSSASAAAAAAAASSSASC*SR.R
724


C100
protein 4







P51812_
RPS6KA3 Ribosomal protein S6
R.QGYDAAC*DIWSLGVLLYTMLTGYTPFA
725


C599
kinase alpha-3
NGPDDTPEEILAR.I






Q86U44_
METTL3 N6-adenosine-
K.GNPQGFNQGLDC*DVIVAEVR.S
726


C500
methyltransferase 70 kDa subunit







Q9H479_
FN3K Fructosamine-3-kinase
R.AFGGPGAGC*ISEGR.A
727


C24








Q9UPT9_
USP22 Ubiquitin carboxyl-terminal
R.AIYQC*FVWSGTAEAR.K
728


C44
hydrolase 22







P30042_
C21orf33 ES1 protein homolog,
K.VVTTPAFMC*ETALHYIHDGIGAMVR.K
729


C244
mitochondrial







Q8NFY9_
KBTBD8 Kelch repeat and BTB
R.IQGLAAVYKDSIYYIAGTC*GNHQR.M
730


C490
domain-containing protein 8







Q9UHQ1_
NARF Nuclear prelamin A
K.VLVVSVC*PQSLPYFAAK.F
731


C99
recognition factor







Q15042_
RAB3GAP1 Rab3 GTPase-activating
K.IGC*PLTPLPPVSIAIR.F
732


C218
protein catalytic subunit







Q9H0E9_
BRD8 Bromodomain-containing
K.LC*LASSVMR.S
733


C26
protein 8







P51878_
CASP5 Caspase-5
K.VIIVQAC*R.G
734


C315








Q9UPQ9_
TNRC6B Trinucleotide repeat-
R.SYRPTHPDC*QAVLQTLLSR.T
735


C600
containing gene 6B protein







P27540_
ARNT Aryl hydrocarbon receptor
K.MTAYITELSDMVPTC*SALAR.K
736


C119
nuclear translocator







Q96C01_
FAM136A Protein FAM136A
R.C*HVPLAQAQALVTSELEK.F
737


C57








Q9NQZ5_
STARD7 StAR-related lipid transfer
R.YC*VSWMVSSGMPDFLEK.L
738


C302
protein 7, mitochondria+







Q9H9P8_
L2HGDH L-2-hydroxyglutarate
K.AC*FLGATVK.Y
739


C376
dehydrogenase, mitochondria+







Q8NBX0_
SCCPDH Saccharopine
R.WPISYC*R.E
740


C238
dehydrogenase-like oxidoreductase







Q8NFF5_
FLAD1 FAD synthase
R.TDPYSCSLC*PFSPTDPGWPAFMR.I
741


C499








Q6PJG6_
BRAT1 BRCA1-associated ATM
R.C*QSPWTEALWVR.L
742


C228
activator 1







Q9C0C2_
TNKS1BP1 182 kDa tankyrase-1-
K.DLQSEFGITGDPQPSSFSPSSWC*QGASQ
743


C749
binding protein
DYGLOGASPR.G






Q9Y4C1_
KDM3A Lysine-specific demethylase
K.IVDPSLIHVEVVHDNLVTC*GNSAR.I
744


C251
3A







Q8N5C7_
DTWD1 DTW domain-containing
K.IFTDERLQGLLQVELICTRKTC*FWRHQK.
745


C235
protein 1
G






Q9BVP2_
GNL3 Guanine nucleotide-binding
K.KLYC*QELK.K
746


C131
protein-like 3







Q6ZS81_
WDFY4 WD repeat- and FYVE
R.DGKEPQPSAEAAAAPSLANISC*FTQK.L
747


C1963
domain-containing protein 4







O94829_
IPO13 Importin-13
R.TSLAVECGAVFPLLEQLLQQPSSPSC*VR.
748


C217

Q






Q9BRT3_
MIEN1 Migration and invasion
R.IVVEYCEPC*GFEATYLELASAVK.E
749


C33
enhancer 1







Q9BRJ7_
NUDT16L1 Protein syndesmos
K.C*QLLFALK.V
750


C171








Q96NE9_
FRMD6 FERM domain-containing
R.KLIYYTGC*PMR.S
751


C306
protein 6







Q70CQ2_
USP34 Ubiquitin carboxyl-terminal
R.LATSAYDGC*SNSELCGMDQFWGIALR.A
752


C1090
hydrolase 34







O00622_
CYR61 Protein CYR61
TQPCDHTKK.TQPC*DHTK.G
753


C70








Q6VMQ6_
ATF7IP Activating transcription
K.LCALQC*AVFDK.T
754


C612
factor 7-interacting protein 1







P68371_
TUBB4B Tubulin beta-4B chain
K.VSDTVVEPYNATLSVHQLVENTDETYC*I
755


C213

DNEALYDIC*FR.T






P04150_
NR3C1 Glucocorticoid receptor
R.QSSANLLC*FAPDLIINEQR.M
756


C622








Q8WVB6_
CHTF18 Chromosome transmission
R.SGEEEAAQPLGAPEEEPTDGQDASSHC*L
757


C280
fidelity protein 18 homolog
WVDEFAPR.H






Q7Z401_
DENND4A C-myc promoter-binding
R.LWSSPAFSPTC*PFR.E
758


C1289
protein









Table 2 illustrates an exemplary list of liganded cysteines which are identified from isoTOP-ABPP experiments performed in situ. Table 2 further shows the accession number (or the protein identifier) of the protein, cysteine residue number, and an illustrative peptide fragment containing the cysteine of interest (denoted by C*).












TABLE 2








SEQ ID


Identifier
Protein Name
Illustrative Cysteine Fragment
NO:


















P04406_
GAPDH Glyceraldehyde-3-phosphate
K.IISNASC*TTNCLAPLAK.V
759


C152
dehydrogenase







P61978_
HNRNPK Heterogeneous nuclear
K.IIPTLEEGLQLPSPTATSQLPLESDAVE
760


C132
ribonucleoprotein K
C*LNYQHYK.G






Q13526_
PIN1 Peptidyl-prolyl cis-trans
K.IKSGEEDFESLASQFSDC*SSAK.A
761


C113
isomerase NIMA-interacting 1







P24752_
ACAT1 Acetyl-CoA acetyltransferase,
R.QAVLGAGLPISTPC*TTINK.V
762


C119
mitochondrial







P24752_
ACAT1 Acetyl-CoA acetyltransferase,
K.QGEYGLASIC*NGGGGASAMLIQK.L
763


C413
mitochondrial







Q9NUY8_
TBC1D23 TBC1 domain family member
K.FLENTPSSLNIEDIEDLFSLAQYYC*S
764


C283
23
K.T






P13667_
PDIA4 Protein disulfide-isomerase A4
K.ENFDEVVNDADIILVEFYAPWC*GHC
765


C206

K.K






P12268_
IMPDH2 Inosine-5-monophosphate
R.HGFC*GIPITDTGR.M
766


C140
dehydrogenase 2







Q15365_
PCBP1 Poly(rC)-binding protein 1
R.VMTIPYQPMPASSPVIC*AGGQDR.C
767


C194








Q9NVC6_
MED17 Mediator of RNA polymerase II
K.MELLMSALSPC*LL
768


C649
transcription subunit







P42166_
TMPO Lamina-associated polypeptide
K.VDDEILGFISEATPLGGIQAASTESC*
769


C561
2, isoform alpha
NQQLDLALCR.A






Q9Y696_
CLIC4 Chloride intracellular channel
K.AGSDGESIGNC*PFSQR.L
770


C35
protein 4







P10599_
TXN Thioredoxin
K.LVVVDFSATWC*GPCK.M
771


C32








P31943_
HNRNPH1 Heterogeneous nuclear
R.DLNYC*FSGMSDHR.Y
772


C267
ribonucleoprotein H







Q86SX6_
GLRX5 Glutaredoxin-related protein
K.GTPEQPQC*GFSNAVVQILR.L
773


C67
5, mitochondrial







P15121_
AKR1B1 Aldose reductase
R.VC*ALLSCTSHK.D
774


C299








P52597_
HNRNPF Heterogeneous nuclear
R.DLSYC*LSGMYDHR.Y
775


C267
ribonucleoprotein F







Q9ULV4_
CORO1C Coronin-1C
K.KC*DLISIPK.K
776


C420








P62888_
RPL30 60S ribosomal protein L30
R.VC*TLAIIDPGDSDIIR.S
777


C92








Q9NQR4_
NIT2 Omega-amidase NIT2
R.VGLGIC*YDMR.F
778


C153








P42765_
ACAA2 3-ketoacyl-CoA thiolase,
R.LC*GSGFQSIVNGCQEICVK.E
779


C92
mitochondrial







Q15084_
PDIA6 Protein disulfide-isomerase
R.EVIQSDSLWLVEFYAPWC*GHCQR.L
780


C55
A6







Q96HE7_
ERO1L ERO1-like protein alpha
K.RPLNPLASGQGTSEENTFYSWLEGLC
781


C241

*VEK.R






Q99439_
CNN2 Calponin-2
K.AGQC*VIGLQMGTNK.C
782


C164








P25205_
MCM3 DNA replication licensing factor
R.TLTSC*FLSCVVCVEGIVTK.C
783


C119
MCM3







Q9NS86_
LANCL2 LanC-like protein 2
R.SVVC*QESDLPDELLYGR.A
784


C187








Q15233_
NONO Non-POU domain-containing
R.FAC*HSASLTVR.N
785


C145
octamer-binding protein







Q9BRA2_
TXNDC17 Thioredoxin domain-
K.SWC*PDCVQAEPVVR.E
786


C43
containing protein 17







P35611_
ADD1 Alpha-adducin
R.VSMILQSPAFC*EELESMIQEQFK.K
787


C68








O75521_
ECI2 Enoyl-CoA delta isomerase 2,
R.WLSDEC*TNAVVNFLSR.K
788


C380
mitochondrial







Q9BXW7_
CECR5 Cat eye syndrome critical
R.DLC*FSPGLMEASHVVNDVNEAVQL
789


C392
region protein 5
VFR.K






P30101_
PDIA3 Protein disulfide-isomerase
K.SEPIPESNDGPVKVVVAENFDEIVNN
790


C406
A3
ENKDVLIEFYAPWC*GHCK.N






Q96AB3_
ISOC2 Isochorismatase domain-
R.SVLLCGIEAQAC*ILNTTLDLLDR.G
791


C114
containing protein 2, mitochondrial







P13667_
PDIA4 Protein disulfide-isomerase
K.KDVLIEFYAPWC*GHCK.Q
792


C555
A4







Q09161_
NCBP1 Nuclear cap-binding protein
K.SAC*SLESNLEGLAGVLEADLPNYK.
793


C44
subunit 1
S






P78417_
GSTO1 Glutathione S-transferase
R.FC*PFAER.T
794


C32
omega-1







Q9ULW0_
TPX2 Targeting protein for Xklp2
R.TVEIC*PFSFDSR.D
795


C536








Q9NRG0_
CHRAC1 Chromatin accessibility
K.ATELFVQC*LATYSYR.H
796


C55
complex protein 1







Q96T76_
MMS19 MMS19 nucleotide excision
R.LMGLLSDPELGPAAADGFSLLMSDC
797


C848
repair protein homolog
*TDVLTR.A






Q8TAQ2_
SMARCC2 SWI/SNF complex subunit
K.SLVQNNCLSRPNIFLC*PEIEPK.L
798


C145
SMARCC2







Q9BVC5_
C2orf49 Ashwin
R.SC*TDSELLLHPELLSQEFLLLTLEQK.
799


C10

N






Q7Z2W4_
ZC3HAV1 Zinc finger CCCH-type
K.NSNVDSSYLESLYQSC*PR.G
800


C645
antiviral protein 1







Q9BQ69_
MACROD1 O-acetyl-ADP-ribose
K.LEVDAIVNAANSSLLGGGGVDGC*IH
801


C186
deacetylase MACRODI
R.A






Q16831_
UPP1 Uridine phosphorylase 1
R.IGTSGGIGLEPGTVVITEQAVDTC*FK.
802


C162

A






P30101_
PDIA3 Protein disulfide-isomerase
R.ISDTGSAGLMLVEFFAPWC*GHCK.R
803


C571
A3







P12268_
IMPDH2 Inosine-5-monophosphate
R.VGMGSGSIC*ITQEVLACGRPQATAV
804


C331
dehydrogenase 2
YK.V






O95571_
ETHE1 Protein ETHE1, mitochondrial
R.TDFQQGC*AK.T
805


C170








O00299_
CLIC1 Chloride intracellular channel
K.IGNC*PFSQR.L
806


C24
protein 1







O14879_
IFIT3 Interferon-induced protein
K.GLNPLNAYSDLAEFLETEC*YQTPFN
807


C343
with tetratricopeptide
K.E






Q96CM8_
ACSF2 Acyl-CoA synthetase family
R.MVSTPIGGLSYVQGC*TK.K
808


C64
member 2, mitochondrial







P51946_
CCNH Cyclin-H
R.TC*LSQLLDIMK.S
809


C244








P49588_
AARS Alanine-tRNA ligase,
K.C*LSVMEAK.V
810


C773
cytoplasmic







Q96RN5_
MED15 Mediator of RNA polymerase II
K.QQYLC*QPLLDAVLANIR.S
811


C618
transcription subunit







O15294_
OGT UDP-N-acetylglucosarnine-peptide
K.C*PDGGDNADSSNTALNMPVIPMNTI
812


C758
N-acetylglucosaminyl transferase
AEAVIEMINR.G






P46734_
MAP2K3 Dual specificity mitogen-
K.MC*DEGISGYLVDSVAK.T
813


C207
activated protein kinase







Q96S55_
WRNIP1 ATP ase WRNIP1
R.SLLETNELPSLILWGPPGC*GK.T
814


C272








O95229_
ZWINT ZW10 interactor
K.LLC*SQLQVADFLQNILAQEDTAK.G
815


C54








O60610_
DIAPH1 Protein diaphanous homolog 1
K.AGC*AVTSLLASELTK.D
816


C1227








Q13428_
TCOF1 Treacle protein
K.C*FLAQPVTLLDIYTHWQQTSELGR.
817


C38

K






Q9Y277_
VDAC3 Voltage-dependent anion-
K.VC*NYGLTFTQK.W
818


C65
selective channel protein







P57764_
GSDMD Gasdermin-D
R.C*LHNFLTDGVPAEGAFTEDFQGLR.
819


C268

A






Q9Y3A3_
MOB4 MOB-like protein phocein
R.HTLDGAAC*LLNSNK.Y
820


C134








Q02252_
ALDH6A1 Methylmalonate-semialdehyde
R.C*MALSTAVLVGEAKIC
821


C317
dehydrogenase







Q9NYL9_
TMOD3 Tropomodulin-3
K.VSLDPELEEALTSASDTELC*DLAAIL
822


C132

GMHNLITNTK.F






P83731_
RPL24 60S ribosomal protein L24
K.VELC*SFSGYK.I
823


C6








O95336_
PGLS 6-phosphogluconolactonase
R.AAC*CLAGAR.A
824


C32








Q13155_
AIMP2 Aminoacyl tRNA synthase
K.SPWLAGNELTVADVVLWSVLQQIGG
825


C291
complex-interacting multif
C*SVTVPANVQR.W






Q13418_
ILK Integrin-linked protein kinase
K.FSFQC*PGR.M
826


C346








A6NDU8_
C5orf51 UPF0600 protein C5orf51
R.C.PIQLNEGVSFQDLDTAK.L
827


C179








Q9UKF6_
CPSF3 Cleavage and polyadenylation
R.NFNYHILSPC*DLSNYTDLAMSTVK.
828


C498
specificity factor subunit
Q






Q96F86_
EDC3 Enhancer of mRNA-decapping
K.DLPTSPVDLVINCLDC*PENVFLR.D
829


C413
protein 3







P42224_
STAT1 Signal transducer and
R.NLSFFLTPPC*AR.W
830


C492
activator of transcription 1







P11216_
PYGB Glycogen phosphorylase, brain
R.TC*FETFPDK.V
831


C326
form







P21980_
TGM2 Protein-glutamine gamma-
K.YGQC*WVFAAVACTVLR.C
832


C277
glutamyltransferase 2







Q9HAV7_
GRPEL1 GrpE protein homolog 1,
K.ATQC*VPKEEIICDDNPIILK.N
833


C124
mitochondrial







P24752_
ACAT1 Acetyl-CoA acetyltransferase,
K.VC*ASGMK.A
834


C126
mitochondrial







Q9NQ88_
TIGAR Fructose-2,6-bisphosphatase
K.EADQKEQFSQGSPSNC*LETSLAEIFP
835


C161
TIGAR
LGK.N






Q13155_
AIMP2 Aminoacyl tRNA synthase
R.VELPTC*MYR.L
836


C23
complex-interacting multif







Q9NQW6_
ANLN Actin-binding protein anillin
K.NNAFPC*QVNIK.Q
837


C712








P51649_
ALDH5A1 Succinate-semialdehyde
R.NTGQTC*VCSNQFLVQR.G
838


C340
dehydrogenase, mitochondrial







Q15021_
NCAPD2 Condensin complex subunit 1
K.NAIQLLASFLANNPFSC*K.L
839


C439








Q5T0N5_
FNBP1L Formin-binding protein 1-like
R.FTSC*VAFFNILNELNDYAGQR.E
840


C69








P38606_
ATP6V1A V-type proton ATPase
KMDFTPC*K.N
841


C138
catalytic subunit A







Q9HCC0_
MCCC2 Methylcrotonoyl-CoA
K.NIAQIAVVMGSC*TAGGAYVPAMAD
842


C216
carboxylase beta chain, mitoch
ENTIVR.K






Q9NQC3_
RTN4 Reticulon-4
K.YSNSALGHVNC*TIK.E
843


C1101








P35754_
GLRX Glutaredoxin-1
K.VVVFIKPTC*PYCR.R
844


C23








Q99757_
TXN2 Thioredoxin, mitochondrial
R.VVNSETPVVVDFHAQWC*GPCK.I
845


C90








Q9Y3D0_
FAM96B Mitotic spindle-associated
R.VQVSDPESTVAVAFTPTIPHC*SMAT
846


C93
MMXD complex subunit MI
LIGLSIK.V






Q9UMS0_
NFU1 NFU1 iron-sulfur cluster
K.LQGSCTSC*PSSIITLK.N
847


C213
scaffold homolog, mitochondrial







Q9NXV6_
CDKN2AIP CDKN2A-interacting protein
K.SVYLGTGC*GK.S
848


C516








Q96RS6_
NUDCD1 NudC domain-containing
R.DSAQC*AAIAER.L
849


C376
protein 1







Q14997_
PSME4 Proteasome activator complex
K.QQFTDDQLLVLTDLLVSPC*YYA
850


C1840
subunit 4







P50570_
DNM2 Dynamin-2
K.LQDAFSSIGQSC*HLDLPQIAVVGGQ
851


C27

SAGK.S






Q86YH6_
PDSS2 Decaprenyl-diphosphate
R.C*LLSDELSNIAMQVR.K
852


C71
synthase subunit 2







Q99497_
PARK7 Protein DJ-1
K.GLIAAIC*AGPTALLAHEIGFGSK.V
853


C106








Q9UJW0_
DCTN4 Dynactin subunit 4
R.LLQPDFQPVC*ASQLYPR.H
854


C258








Q9BUH6_
C9orf142 Uncharacterized protein
R.C*PGESLINPGFK.S
855


C180
C9orf142







P24752_
ACAT1 Acetyl-CoA acetyltransferase,
K.IHMGSC*AENTAK.K
856


C196
mitochondrial







Q13162_
PRDX4 Peroxiredoxin-4
R.EEEC*HFYAGGQVYPGEASR.V
857


C51








Q9BTA9_
WAC WW domain-containing adapter
R.STC*SLTPALAAHFSENLIK.H
858


C553
protein with coiled-coil







P48643_
CCT5 T-complex protein 1 subunit
K.IAILTC*PFEPPKPK.T
859


C253
epsilon







O75362_
ZNF217 Zinc finger protein 217
R.C*IPQLDPFTTFQAWQLATK.G
860


C286








O60825_
PFKFB2 6-phosphofructo-2-kinase/
K.VFFVESVC*DDPDVIAANILEVK.V
861


C158
fructose-2,6-bisphosphatase 2







Q8NBS9_
TXNDC5 Thioredoxin domain-containing
K.FYAPWC*GHCK.T
862


C350
protein 5







Q9NYL2_
MLTK Mitogen-activated protein kinase
K.FDDLQFFENC*GGGSFGSVYR.A
863


C22
kinase kinase MLT







P27707_
DCK Deoxycytidine kinase
R.SC*PSFSASSEGTR.I
864


C9








Q93009_
USP7 Ubiquitin carboxyl-terminal
K.NQGATC*YMNSLLQTLFFTNQLR.K
865


C223
hydrolase 7







O14929_
HAT1 Histone acetyltransferase type
K.VDENFDC*VEADDVEGKJ
866


C101
B catalytic subunit







Q9UPQ0_
LIMCH1 LIM and calponin homology
K.AANSC*TSYSGTTLNLK.E
867


C140
domains-containing protein







Q96NY7_
CLIC6 Chloride intracellular channel
R.AGYDGESIGNC*PFSQR.L
868


C487
protein 6







Q9NQ88_
TIGAR Fructose-2,6-bisphosphatase
R.EEC*PVFTPPGGETLDQVK.M
869


C114
TIGAR







Q14790_
CASP8 Caspase-8
K.VFFIQAC*QGDNYQK.G
870


C360








P04183_
TK1 Thymidine kinase, cytosolic
K.LFAPQQILQC*SPAN.-
871


C230








P68366_
TUBA4A Tubulin alpha-4A chain
K.TIGGGDDSFTTFFC*ETGAGK.H
872


C54








Q13428_
TCOF1 Treacle protein
K.GAGNPQASTLALQSNITQC*LLGQP
873


C1298

WPLNEAQVQASVVK.V






Q5MNZ6_
WDR45L WD repeat domain
R.C*NYLALVGGGK.K
874


C63
phosphoinositide-interacting protein







O14980_
XPO1 Exportin-1
K.DLLGLC*EQK.R
875


C528








Q86W42_
THOC6 THO complex subunit 6 homolog
R.LHMTIFSQSVSPC*GK.F
876


C35








Q9Y6G9_
DYNC1LI1 Cytoplasmic dynein 1 light
R.VGSFGSSPPGLSSTYTGGPLGNEIASG
877


C51
intermediate chain 1
NGGAAAGDDEDGQNLWSC*ILSEVSTR





.S






Q9NY27_
PPP4R2 Serine/threonine-protein
K.EVC*PVLDQFLCHVAK.T
878


C22
phosphatase 4 regulatory







Q8NFH5_
NUP35 Nucleoporin NUP53
R.C*ALSSPSLAFTPPIK.T
879


C255








Q9Y676_
MRPS18B 28S ribosomal protein S18b,
K.LLEQFVC*AHTGIIFYAPYTGVCVK.Q
880


C128
mitochondrial







P35658_
NUP214 Nuclear pore complex protein
K.AC*FQVGTSEEMK.M
881


C728
Nup214







Q9NTX5_
ECHDC1 Ethylmalonyl-CoA
K.SLGTPEDGMAVC*MFMQNTLTR.F
882


C133
decarboxylase







Q15118_
PDK1
K.QFLDFGSVNAC*EK.T
883


C71








Q00765_
REEP5 Receptor expression-enhancing
K.NC*MTDLLAK.L
884


C18
protein 5







P22307_
SCP2 Non-specific lipid-transfer
K.ALADAQIPYSAVDQACVGYVFGDST
885


C71
protein
C*GQR.A






O75521_
ECI2 Enoyl-CoA delta isomerase 2,
K.KLTAGEAC*AQGLVTEVFPDSTFQK.
886


C312
mitochondrial
E






P49189_
ALDH9A1 4-
K.GALMANFLTQGQVC*CNGTR.V
887


C288
trimethylaminobutyraldehyde





dehydrogenase







Q5T440_
IBA57 Putative transferase CAF17,
R.VWAVLPSSPEAC*GAASLQER.A
888


C170
mitochondrial







Q15084_
PDIA6 Protein disulfide-isomerase A6
K.DVIELTDDSFDKNVLDSEDVWMVEF
889


C190

YAPWC*GHCK.N






Q96C19_
EFHD2 EF-hand domain-containing
K.AAAGELQEDSGLC*VLAR.L
890


C172
protein D2







P22061_
PCMT1 Protein-L-isoaspartate
R.MVGC*TGK.V
891


C102
(D-aspartate) O-methyltransferase







Q9NP73_
ALG13 UDP-N-acetylglucosamine
K.ADLVISHAGAGSC*LETLEK.G
892


C86
transferase subunit ALG13







Q9BRF8_
CPPED1 Calcineurin-like 
K.AWSTGDC*DNGGDEWEQEIR.L
893


C54
phosphoesterase domain-containing







Q6ICB0_
DESI1 Desumoylating isopeptidase 1
R.GEAYNLFEHNC*NTFSNEVAQFLTGR
894


C108

.K






P29590_
PML Protein PML
R.LQDLSSC*ITQGK.D
895


C389








P07858_
CTSB Cathepsin B
K.IC*EPGYSPTYK.Q
896


C211








Q9NX18_
SDHAF2 Succinate dehydrogenase
R.GMLENC*ILLSLFAK.E
897


C83
assembly factor 2, mitochondrial







P46109_
CRKL Crk-like protein
K.RVPC*AYDK.T
898


C249








P45984_
MAPK9 Mitogen-activated protein
R.TAC*INFMMTPYVVTR.Y
899


C177
kinase 9







P19447_
ERCC3 TFIIH basal transcription
R.SGVIVLPC*GAGK.S
900


C342
factor complex helicase







P42166_
TMPO Lamina-associated polypeptide
K.SGIQPLC*PER.S
901


C341
2, isoform alpha







Q8N1F7_
NUP93 Nuclear pore complex protein
K.SSGQSAQLLSHEPGDPPC*LR.R
902


C522
Nup93







Q86UY8_
NT5DC3 5-nucleotidase domain-
K.YIC*YAEQTR.A
903


C276
containing protein 3







Q8WWI1_
LMO7 LIM domain only protein 7
R.DSGYGDIWC*PER.G
904


C228








Q9NWA0_
MED9 Mediator of RNA polymerase II
K.SLC*MFEIPKE
905


C139
transcription subunit







P09110_
ACAA1 3-ketoacyl-CoA thiolase,
K.VNPLGGAVALGHPLGC*TGAR.Q
906


C381
peroxisomal







Q2NL82_
TSR1 Pre-rRNA-processing protein
R.DTGTVHLNELGNTQNFMLLC*PR.L
907


C126
TSR1 homolog







Q5JPI3_
C3orf38 Uncharacterized protein
K.FEQSDLEAFYNVITVC*GTNEVR.H
908


C308
C3orf38







P23919_
DTYMK Thymidylate kinase
R.C*FHQLMK.D
909


C163








Q96EB1_
ELP4 Elongator complex protein 4
K.VEPC*SLTPGYTK.L
910


C218








Q96FX7_
TRMT61A tRNA (adenine(58)-N(1))-
R.FCSFSPC*TEQVQR.T
911


C209
methyltransferase catalytic





subunit TRMT61A







O14933_
UBE2L6 Ubiquitin/ISG15-conjugating
K.IYHPNVDENGQICLPIISSENWKPC*T
912


C98
enzyme E2 L6
K.T






Q29RF7_
PDS5A Sister chromatid cohesion
R.TVQTIEAC*IANFFNQVLVLGR.S
913


C242
protein PDS5 homolog A







Q96T76_
MMS19 MMS19 nucleotide excision
R.YHPLSSC*LTAR.L
914


C819
repair protein homolog







P23919_
DTYMK Thymidylate kinase
K.ENFSLDWC*K.Q
915


C117








Q15149_
PLEC Plectin
K.YLTC*PK.T
916


C4574








Q96RP9_
GFM1 Elongation factor G,
R.VLDGAVLVLCAVGGVQC*QTMTVN
917


C153
mitochondrial
R.Q






P04818_
TYMS Thymidylate synthase
R.DLPLMALPPCHALC*QFYVVNSELSC
918


C199

QLYQR.S






P27708_
CAD CAD protein
K.AQILVLTYPLIGNYGIPPDEMDEFGL
919


C73

C*K.W






P55265_
ADAR Double-stranded RNA-specific
K.NFYLC*PV
920


C1224
adenosine deaminase







Q9Y3D2_
MSRB2 Methionine-R-sulfoxide
K.YC*SGTGWPSFSEAHGTSGSDESHTG
921


C105
reductase B2, mitochondrial
ILR.R






O00244_
ATOX1 Copper transport protein ATOX1
K.HEFSVDMTC*GGCAEAVSR.V
922


C12








Q8WV74_
NUDT8 Nucleoside diphosphate-linked
R.LAGLTC*SGAEGLARPK.Q
923


C207
moiety X motif 8, mitochondrial







Q9NRW3_
APOBEC3C Probable DNA dC-dU-editing
R.LYYFQYPC*YQEGLR.S
924


C130
enzyme APOBEC-3C







P24468_
NR2F2 COUP transcription factor 2
K.AIVLFTSDAC*GLSDVAHVESLQEK.S
925


C326








P42166_
TMPO Lamina-associated polypeptide
K.GGTLFGGEVC*K.V
926


C684
2, isoform alpha







Q96EY5_
FAM125A Multivesicular body subunit
K.SC*SPLAFSAFGDLTIK.S
927


C231
12A







P14635_
CCNB1 G2/mitotic-specific cyclin-B1
R.FMQNNC*VPK.K
928


C238








Q8NDH3_
NPEPL1 Probable aminopeptidase
R.VTEELWQAALSTLNPNPTDSCPLYLN
929


C81
NPEPL1
YATVAALPC*R.V






Q9P0J1_
PDP1
R.GMLLGVFDGHAGC*ACSQAVSER.L
930


C149








Q96P48_
ARAP1 Arf-GAP with Rho-GAP domain,
R.AVFPEGPC*EEPLQLR.K
931


C900
ANK repeat and PH domain-containing





protein 1







Q96HE7_
ERO1L ERO1-like protein alpha
R.CFC*QVSGYLDDCTCDVETIDR.F
932


C37








Q07065_
CKAP4 Cytoskeleton-associated
K.SSSSSSASAAAAAAAASSSASC*SR.R
933


C100
protein 4







Q9BRJ7_
NUDT16L1 Protein syndesmos
R.VLGLGLGC*LR.L
934


C88








O75439_
PMPCB Mitochondrial-processing
K.FHFGDSLC*THK.G
935


C265
peptidase subunit beta







O43175_
PHGDH D-3-phosphoglycerate
K.NAGNC*LSPAVIVGLLK.E
936


C369
dehydrogenase







Q9UNI6_
DUSP12 Dual specificity protein
R.QAQC*TSYFIEPVQWMESALLGVMD
937


C265
phosphatase 12
GQLLCPK.C






Q06203_
PPAT Amidophosphoribosyltransferase
K.C*ELENCQPFVVETLHGKI
938


C100








A0AVT1_
UBA6 Ubiquitin-like modifier-
R.KPNVGC*QQDSEELLK.L
939


C347
activating enzyme 6







Q86X76_
NIT1 Nitrilase homolog 1
KIGLAVC*YDMR.F
940


C203








Q6XZE7_
DNMBP Dynamin-binding protein
R.SLDQTSPC*PLVLVR.I
941


C691








Q15398_
DLGAP5 Disks large-associated
R.YRPDMPC*FLLSNQNAVK.A
942


C129
protein 5







O75717_
WDHD1 WD repeat and HMG-box
CK.MLALSC*K.L
943


773
DNA-binding protein 1







Q01433_
AMPD2 AMP deaminase 2
R.SLPGPAPC*LK.H
944


C107








Q8WVV9_
HNRPLL Heterogeneous nuclear
K.NIIQPPSCVLHYYNVPLC*VTEETFTK
945


C464
ribonucleoprotein L-like
.L






O14733_
MAP2K7 Dual specificity mitogen-
R.YQAEINDLENLGEMGSGTC*GQVWK
946


C131
activated protein kinase
.M






Q14137_
BOP1 Ribosome biogenesis protein
R.DLQPFPTC*QALVYR.G
947


C404
BOP1







Q96RU2_
USP28 Ubiquitin carboxyl-terminal
K.NVGNTC*WFSAVIQSLFQLPEFR.R
948


C171
hydrolase 28







Q9Y679_
AUP1 Ancient ubiquitous protein 1
K.TGC*VDLTITNLLEGAVAFMPEDITK
949


C391

G






P51610_
HCFC1 Host cell factor 1
R.VAGINAC*GR.G
950


C1872








P22307_
SCP2 Non-specific lipid-transfer
K.SGLTPNDIDVIELHDC*FSTNELLTYE
951


C307
protein
ALGLCPEGQGATLVDR.G






Q9BTE3_
MCMBP Mini-chromosome maintenance
K.LQHINPLLPAC*LNK.E
952


C325
complex-binding protein







Q9HA64_
FN3KRP Ketosamine-3-kinase
R.ATGHSGGGC*ISQGR.S
953


C24








Q5TFE4_
NT5DC1 5-nucleotidase domain-
K.HFLSDTGMAC*R.S
954


C119
containing protein 1







Q96N67_
DOCK7 Dedicator of cytokinesis
K.AVLPVTC*HR.D
955


C2125
protein 7







P52948_
NUP98 Nuclear pore complex protein
R.WLSC*TATPQLEEEVSLTQK.N
956


C1312
Nup98-Nup96







Q5U1P0_
RIF1 Telomere-associated protein
K.ESIPCPTESVYPPLVNC*VAPVDIELPQ
957


C2298
RIF1
ITSNMWAR.G






P51812_
RPS6KA3 Ribosomal protein S6 kinase
K.EDIGVGSYSVC*K.R
958


C436
alpha-3







Q92616_
GCN1L1 Translational activator GCN1
K.GMGESC*FEDLLPWLMETLTYEQSS
959


C1692

VDR.S






Q15345_
LRRC41 Leucine-rich repeat-containing
R.C*AAALMASR.R
960


C297
protein 41







Q9NPH0_
ACP6 Lysophosphatidic acid
R.MGIDSSDKVDFFILLDNVAAEQAHN
961


C267
phosphatase type 6
LPSC*PMIX.R






P04183_
TK1 Thymidine kinase, cytosolic
R.YSSSFC*THDR.N
962


C66








P42166_
TMPO Lamina-associated polypeptide 2,
K.TYDAASYIC*EAAFDEVK.M
963


C629
isoform alpha







Q15013_
MAD2L1BP MAD2L1-binding protein
K.C*QQALAELESVLSHLEDFFAR.T
964


C124








Q9Y5Y2_
NUBP2 Cytosolic Fe-S cluster assembly
R.AVHQC*DR.G
965


C72
factor NUBP2







O15446_
CD3EAP DNA-directed RNA polymerase
R.VLSSC*PQAGEATLLAPSTEAGGGLT
966


C86
1 subunit RPA34
CASAPQGTLR.I






Q13630_
TSTA3 GDP-L-fucose synthase
R.KVVSCLSTC*IFPDK.T
967


C116








Q8IYQ7_
THNSL1 Threonine synthase-like 1
R.LGEMIETAYGENFAC*SK.I
968


C324








P05091_
ALDH2 Aldehyde dehydrogenase,
K.SPNIIMSDADMDWAVEQAILFALFFN
969


C319
mitochondrial
QGQCC*CAGSR.T






Q29RF7_
PDS5A Sister chromatid cohesion
R.ELLDLHKQPTSEANC*SAMFGK.L
970


C532
protein PDS5 homolog A







Q9Y570_
PPME1 Protein phosphatase
R.FAEPIGGFQC*VFPGC.-
971


C381
methylesterase 1







Q14980_
NUMA1 Nuclear mitotic apparatus
R.QFC*STQAALQAMER.E
972


C961
protein 1







P53384_
NUBP1 Cytosolic Fe-S cluster
K.LPHGVVENMSGFIC*PK.C
973


C235
assembly factor NUBP1







Q15003_
NCAPH Condensin complex subunit 2
R.TMC*PLLSMKPGEYSYFSPR.T
974


C418








P53634_
CTSC Dipeptidyl peptidase 1
R.NQASCGSC*YSFASMGMLEARI
975


C258








Q8NFF5_
FLAD1 FAD synthase
R.TDPYSCSLC*PFSPTDPGWPAFMR.I
976


C499








Q9ULA0_
DNPEP Aspartyl aminopeptidase
K.C*PTSGR.L
977


C144








P22307_
SCP2 Non-specific lipid-transfer
R.AIYHSLGMTGIPIENVININNC*ATGSTA
978


C94
protein
LFMAR.Q






O15294_
OGT UDP-N-acetylglucosamine--peptide
K.VMAEANHFIDLSQIPC*NGK.A
979


C620
N-acetylglucosaminyl transferase







Q9Y5S2_
CDC42BPB Serine/threonine-protein
R.IRPLNSEGTLNLLNC*EPPR.L
980


C1517
kinase MRCK beta







Q8TD19_
NEK9 Serine/threonine-protein kinase
R.LLTFGC*NK.C
981


C623
Nek9







Q8N2W9_
PIAS4 E3 SUMO-protein ligase PIAS4
R.VSLIC*PLVK.M
982


C326








Q13158_
FADD Protein FADD
R.VDDFEAGAAAGAAPGEEDLC*AAFN
983


C98

VICDNVGK.D






Q9UKX7_
NUP50 Nuclear pore complex protein
K.AC*VGNAYHK.Q
984


C151
Nup50







Q6PCB5_
RSBN1L Round spermatid basic protein
K.SIQTIC*SGLLTDVEDQAAK.G
985


C280
1-like protein







P10398_
ARAF Serine/threonine-protein kinase 
R.TQADELPAC*LLSAAR.L
986


C597
A-Raf







Q9UL40_
ZNF346 Zinc finger protein 346
K.NQC*LFTNTQCK.V
987


C68








P46013_
MIC167 Antigen KI-67
K.SEETNTEIVEC*ILK.R
988


C903








Q16667_
CDICN3 Cyclin-dependent kinase
R.VNC*SQFLGLCALPGCK.F
989


C39
inhibitor 3







O75150_
RNF40 E3 ubiquitin-protein ligase
R.EIQPC*LAESR.A
990


C890
BRE1B







Q00610_
CLTC Clathrin heavy chain 1
RIHEGC*EEPATHNALAK.I
991


C870








Q9Y5T5_
USP16 Ubiquitin carboxyl-terminal
K.GLSNLGNTC*FFNAVMQNLSQTPVL
992


C205
hydrolase 16
R.E






O95881_
TXNDC12 Thioredoxin domain-containing
K.SWC*GACK.A
993


C66
protein 12







Q7Z5K2_
WAPAL Wings apart-like protein
R.IVEDDASISSC*NK.L
994


C160
homolog







P42166_
TMPO Lamina-associated polypeptide 2,
R.QLPSLAC*K.Y
995


C518
isoform alpha







Q9Y2S7_
POLD1P2 Polymerase delta-interacting
R.DC*PHISQR.S
996


C143
protein 2







E2QRD5_
C15orf38-AP3S2 Protein C15orf38-
K.C*NFTGDGICT
997


C183
AP3S2







O95833_
CLIC3 Chloride intracellular channel
K.ASEDGESVGHC*PSCQR.L
998


C22
protein 3







O94953_
KDM4B Lysine-specific demethylase 4B
R.TEPYCAICTLFYPYC*QALQTEK.E
999


C694








O00541_
PES1 Pescadillo homolog
K.AGEGTYALDSESC*MEK.L
1000


C272








Q9NXJ5_
PGPEP1 Pymglutamyl-peptidase 1
R.YLC*DFTYYTSLYQSHGR.S
1001


C149








Q8N5L8_
RPP25L Ribonuclease P protein subunit
R.DPLDPNEC*GYQPPGAPPGLGSMPSS
1002


C131
p25-like protein
SCGPR.S






Q8IZ73_
RPUSD2 RNA pseudouridylate synthase
R.LLAENEDVVVVDKPSSIPVHPC*GR.F
1003


C246
domain-containing protein







Q99798_
ACO2 Aconitate hydratase,
R.VGLIGSC*TNSSYEDMGR.S
1004


C385
mitochondrial







Q9GZR2_
REXO4 RNA exonuclease 4
K.ILGLQVQQAEHC*SIQDAQAAMR.L
1005


C382








Q13613_
MTMR1 Myotubularin-related protein 1
K.DVMYIC*PFMGAVSGTLTVTDFK.L
1006


C117








Q9NUI1_
DECR2 Peroxisomal 2,4-dienoyl-CoA
R.HLFC*PDLLR.D
1007


C22
reductase







Q02556_
IRF8 Interferon regulatory factor 8
R.VFCSGNAVVC*K.G
1008


C306








Q9UPT9_
USP22 Ubiquitin carboxyl-terminal
K.ITSNC*TIGLR.G
1009


C171
hydrolase 22







Q8N999_
Cl2orf29 Uncharacterized protein
K.C*LFNHFLK.I
1010


C302
C12orf29







Q8IU81_
IRF2BP1 Interferon regulatory factor
R.SFREPAPAEALPQQYPEPAPAALC*G
1011


C363
2-binding protein 1
PPPR.A






Q9C0I1_
MTMR12 Myotubularin-related
R.VFQFC*LR.Y
1012


C152
protein 12







Q9P2X3_
IMPACT Protein IMPACT
R.STFQAHLAPVVC*PK.Q
1013


C195








Q6QNY0_
BLOC1S3 Biogenesis of lysosome
R.GDLC*ALAER.L
1014


C168
related organelles complex







Q15796_
SMAD2 Mothers against decapentaplegic
K.CVTIPSTC*SEIWGLSTPNTIDQWDTT
1015


C81
homolog 2
GLYSFSEQTR.S






Q9NZB2_
FAM120A Constitutive coactivator of
K.GSQMGTVQPIPC*LLSMPTR.N
1016


C531
PPAR-gamma-like protein







Q9HB90_
RRAGC Ras-related GTP-binding
R.SC*GHQTSASSLK.A
1017


C377
protein C







Q9BR61_
ACBD6 Acyl-CoA-binding domain-
R.DQDGCLPEEVTGC*K.T
1018


C267
containing protein 6







P16455_
MGMT Methylated-DNA--protein-cysteine
R.GNPVPILIPC*HR.V
1019


C145
methyltransferase







Q86UV5_
USP48 Ubiquitin carboxyl-terminal
R.IWLEPC*IR.G
1020


C39
hydrolase 48







A2A288_
ZC3H12D Probable ribonuclease
R.LAFSDDLGPLGPPLPVPAC*SLTPR.L
1021


C367
ZC3H12D







Q8NEC7_
GSTCD Glutathione S-transferase C-
K.AC*AEVSQWTR.L
1022


C140
terminal domain-containing







Q6PJG6_
BRAT1 BRCA1-associated ATM activator
R.THC*PYAVALPEVAPAQPLTEALR.A
1023


C673
1







Q13232_
NME3 Nucleoside diphosphate kinase 3
R.ADELLC*WEDSAGHWLYE
1024


C158








Q86X76_
NIT1 Nitrilase homolog 1
K.THLC*DVEIPGQGPMCESNSTMPGPS
1025


C165

LESPVSTPAGK.I






P42695_
NCAPD3 Condensin-2 complex subunit
R.C*VMAMLR.R
1026


C541
D3







P41226_
UBA7 Ubiquitin-like modifier-
R.APASAAASEDAPYPVC*TVR.Y
1027


C599
activating enzyme 7







Q99986_
VRK1 Serine/threonine-protein kinase
K.VGLPIGQGGFGC*IYLADMNSSESVG
1028


C50
VRK1
SDAPCVVK.V






Q8WUM4_
PDCD61P Programmed cell death 6-
K.FPFSENQIC*LTFTWK.D
1029


C90
interacting protein







P29590_
PML Protein PML
R.GCSKPLCC*SCALLDSSHSELK.0
1030


C213








Q9P0K7_
RAI14 Ankycorbin
K.QILTMC*K.N
1031


C973








P53992_
SEC24C Protein sport protein Sec24C
R.APPSSGAPPASTAQAPC*GQAAYGQF
1032


C78

GQGDVQNGPSSTVQMQR.L






Q13867_
BLMH Bleomycin hydrolase
R.C*WIFSCLNVMR.L
1033


C73








Q8ND24_
RNF214 RING finger protein 214
R.SSHAPATC*K.L
1034


C655








Q96EK4_
THAP11 THAP domain-containing
R.AGVSGC*FSTFQPTTGHR.L
1035


C48
protein 11







Q961V0_
NGLY1 Peptide-N(4)-(N-acetyl-
R.C*GEWANCFTLCCR.A
1036


C309
beta-glucosaminypasparagin







Q5T1V6_
DDX59 Probable ATP-dependent RNA
DDX59 K.NLPC*ANVR.Q
1037


C414
helicase DDX59







Q9UHQ1_
NARF Nuclear prelamin A recognition
K.VLVVSVC*PQSLPYFAAK.F
1038


C99
factor







O43396_
TXNL1 Thioredoxin-like protein 1
R.GC*GPCLR.I
1039


C34








Q81V53_
DENND1C DENN domain-containing
R.GNSKPLSC*FVAPDSGRLPS1PENR.N
1040


C174
protein IC







Q8N9T8_
ICRI1 Protein ICRI1 homolog
R.LLGPTVMLGGC*EFSR.Q
1041


C673









Table 3 illustrates a list of unliganded cysteines. Table 3 further shows the accession number (or the protein identifier) of the protein, cysteine residue number, and the respective SEQ ID NO.











TABLE 3







SEQ




ID


Identifier
Protein Name
NO:

















P26641_C266
EEF1G Elongation factor 1-
1042



gamma


P07900_C374
HSP90AA1 Heat shock protein
1043



HSP 90-alpha


P23528_C139
CFL1 Cofilin-1
1044


P68104_C411
EEF1A1 Elongation factor 1-
1045



alpha 1


P08238_C366
HSP90AB1 Heat shock protein
1046



HSP 90-beta


P60981_C163
DSTN Destrin
1047


P61978_C132
HNRNPK Heterogeneous
1048



nuclear ribonucleoprotein K


P60709_C217
ACTB Actin, cytoplasmic 1
1049


Q15365_C54
PCBP1 Poly(rC)-binding
1050



protein 1


P60709_C272
ACTB Actin, cytoplasmic 1
1051


P27348_C134
YWHAQ 14-3-3 protein theta
1052


P55769_C30
NHP2L1 NHP2-like protein 1
1053


Q6IS14_C129
EIF5AL1 Eukaryotic
1054



translation initiation factor 5A-



1-like


P11413_C13
G6PD Glucose-6-phosphate 1-
1055



dehydrogenase


P04406_C247
GAPDH Glyceraldehyde-3-
1056



phosphate dehydrogenase


P37802_C124
TAGLN2 Transgelin-2
1057


Q13185_C177
CBX3 Chromobox protein
1058



homolog 3


Q9Y3F4_C340
STRAP Serine-threonine
1059



kinase receptor-associated



protein


Q9NTK5_C55
OLA1 Obg-like ATPase 1
1060


P53396_C20
ACLY ATP-citrate synthase
1061


P62826_C112
RAN GTP-binding nuclear
1062



protein Ran


P15880_C229
RPS2 40S ribosomal protein
1063



S2


P08238_C589
HSP90AB1 Heat shock protein
1064



HSP 90-beta


P30084_C62
ECHS1 Enoyl-CoA hydratase,
1065



mitochondrial


P47756_C36
CAPZB F-actin-capping
1066



protein subunit beta


P52292_C223
KPNA2 Importin subunit
1067



alpha-2


Q15366_C109
PCBP2 Poly(rC)-binding
1068



protein 2


P14174_C81
MIF Macrophage migration
1069



inhibitory factor


P61981_C97
YWHAG 14-3-3 protein
1070



gamma


P00338_C163
LDHA L-lactate
1071



dehydrogenase A chain


Q15019_C111
SEPT2 Septin-2
1072


P84243_C111
H3F3B Histone H3.3
1073


P18085_C62
ARF4 ADP-ribosylation factor
1074



4


P10599_C73
TXN Thioredoxin
1075


P13639_C466
EEF2 Elongation factor 2
1076


P00338_C293
LDHA L-lactate
1077



dehydrogenase A chain


P49721_C91
PSMB2 Proteasome subunit
1078



beta type-2


P28062_C160
PSMB8 Proteasome subunit
1079



beta type-8


P10809_C237
HSPD1 60 kDa heat shock
1080



protein, mitochondrial


P60981_C23
DSTN Destrin
1081


P31943_C267
HNRNPH1 Heterogeneous
1082



nuclear ribonucleoprotein H


P49321_C708
NASP Nuclear autoantigenic
1083



sperm protein


Q99829_C53
CPNE1 Copine-1
1084


P68104_C111
EEF1A1 Elongation factor 1-
1085



alpha 1


Q02750_C207
MAP2K1 Dual specificity
1086



mitogen-activated protein



kinase


O14950_C109
MYL12B Myosin regulatory
1087



light chain 12B


P47756_C206
CAPZB F-actin-capping
1088



protein subunit beta


P49327_C1448
FASN Fatty acid synthase
1089


P14868_C349
DARS Aspartate--tRNA
1090



ligase, cytoplasmic


P07437_C201
TUBB Tubulin beta chain
1091


P07437_C303
TUBB Tubulin beta chain
1092


P61077_C111
UBE2D3 Ubiquitin-
1093



conjugating enzyme E2 D3


P15153_C178
RAC2 Ras-related C3
1094



botulinum toxin substrate 2


Q04637_C662
EIF4G1 Eukaryotic translation
1095



initiation factor 4 gamma 1


P78347_C215
GTF2I General transcription
1096



factor II-I


Q15370_C89
TCEB2 Transcription
1097



elongation factor B



polypeptide 2


P62753_C12
RPS6 40S ribosomal protein
1098



S6


P31948_C461
STIP1 Stress-induced-
1099



phosphoprotein 1


Q9UL46_C91
PSME2 Proteasome activator
1100



complex subunit 2


P63220_C56
RPS21 40S ribosomal protein
1101



S21


P55809_C67
OXCT1 Succinyl-CoA: 3-
1102



ketoacid coenzyme A



transferase 1,


P30153_C377
PPP2R1A Serine/threonine-
1103



protein phosphatase 2A 65 kDa



regulatory subunit A alpha



isoform


P30153_C390
PPP2R1A Serine/threonine-
1104



protein phosphatase 2A 65 kDa



regulatory subunit A alpha



isoform


P60866_C70
RPS20 40S ribosomal protein
1105



S20


Q9P258_C428
RCC2 Protein RCC2
1106


P60709_C285
ACTB Actin, cytoplasmic 1
1107


P22234_C81
PAICS Multifunctional protein
1108



ADE2


P27348_C237
YWHAQ 14-3-3 protein theta
1109


P12004_C81
PCNA Proliferating cell
1110



nuclear antigen


P68104_C234
EEF1A1 Elongation factor 1-
1111



alpha 1


Q96FW1_C23
OTUB1 Ubiquitin thioesterase
1112



OTUB1


Q13200_C779
PSMD2 26S proteasome non-
1113



ATPase regulatory subunit 2


P22314_C632
UBA1 Ubiquitin-like modifier-
1114



activating enzyme 1


P37802_C38
TAGLN2 Transgelin-2
1115


P37802_C63
TAGLN2 Transgelin-2
1116


P46782_C172
RPS5 40S ribosomal protein
1117



S5


P04075_C339
ALDOA Fructose-
1118



bisphosphate aldolase A


P05386_C61
RPLP1 60S acidic ribosomal
1119



protein P1


P63000_C178
RAC1 Ras-related C3
1120



botulinum toxin substrate 1


P07195_C294
LDHB L-lactate
1121



dehydrogenase B chain


Q13148_C244
TARDBP TAR DNA-binding
1122



protein 43


P30048_C229
PRDX3 Thioredoxin-
1123



dependent peroxide reductase,



mitochondrial


P62306_C66
SNRPF Small nuclear
1124



ribonucleoprotein F


O15371_C19
EIF3D Eukaryotic translation
1125



initiation factor 3 subunit


P17987_C397
TCP1 T-complex protein 1
1126



subunit alpha


Q9Y5P6_C245
GMPPB Mannose-1-phosphate
1127



guanyltransferase beta


Q9BW61_C25
DDA1 DET1- and DDB1-
1128



associated protein 1


Q14974_C585
KPNB1 Importin subunit beta-
1129



1


Q9BUF5_C303
TUBB6 Tubulin beta-6 chain
1130


P52272_C653
HNRNPM Heterogeneous
1131



nuclear ribonucleoprotein M


O75940_C214
SMNDC1 Survival of motor
1132



neuron-related-splicing factor



3


O00233_C59
PSMD9 26S proteasome non-
1133



ATPase regulatory subunit 9


P63208_C160
SKP1 S-phase kinase-
1134



associated protein 1


Q9Y224_C19
C14orf166 UPF0568 protein
1135



C14orf166


P30626_C194
SRI Sorcin
1136


Q9BXW7_C392
CECR5 Cat eye syndrome
1137



critical region protein 5


P60842_C134
EIF4A1 Eukaryotic initiation
1138



factor 4A-I


P63220_C17
RPS21 40S ribosomal protein
1139



S21


P50990_C149
CCT8 T-complex protein 1
1140



subunit theta


P22234_C63
PAICS Multifunctional protein
1141



ADE2


Q13148_C39
TARDBP TAR DNA-binding
1142



protein 43


P17987_C357
TCP1 T-complex protein 1
1143



subunit alpha


P31946_C96
YWHAB 14-3-3 protein
1144



beta/alpha


P61289_C92
PSME3 Proteasome activator
1145



complex subunit 3


P26641_C68
EEF1G Elongation factor 1-
1146



gamma


P78371_C395
CCT2 T-complex protein 1
1147



subunit beta


P14868_C203
DARS Aspartate--tRNA
1148



ligase, cytoplasmic


Q92530_C185
PSMF1 Proteasome inhibitor
1149



PI31 subunit


P25398_C92
RPS12 40S ribosomal protein
1150



S12


P25205_C148
MCM3 DNA replication
1151



licensing factor MCM3


P60174_C79
TPI1 Triosephosphate
1152



isomerase


P43487_C132
RANBP1 Ran-specific
1153



GTPase-activating protein


P62280_C131
RPS11 40S ribosomal protein
1154



S11


P13639_C651
EEF2 Elongation factor 2
1155


P13639_C751
EEF2 Elongation factor 2
1156


Q9NUQ9_C10
FAM49B Protein FAM49B
1157


P62937_C62
PPIA Peptidyl-prolyl cis-trans
1158



isomerase A


P23528_C39
CFL1 Cofilin-1
1159


P46776_C70
RPL27A 60S ribosomal
1160



protein L27a


P49915_C456
GMPS GMP synthase
1161


Q16851_C123
UGP2 UTP-glucose-1-
1162



phosphate uridylyltransferase


P14618_C358
PKM Pyruvate kinase
1163



isozymes M1/M2


P14618_C474
PKM Pyruvate kinase
1164



isozymes M1/M2


P13489_C409
RNH1 Ribonuclease inhibitor
1165


O15355_C241
PPM1G Protein phosphatase
1166



1G


P68431_C111
HIST1H3J Histone H3.1
1167


P08238_C521
HSP90AB1 Heat shock protein
1168



HSP 90-beta


Q99439_C175
CNN2 Calponin-2
1169


O00299_C223
CLIC1 Chloride intracellular
1170



channel protein 1


Q96KB5_C22
PBK Lymphokine-activated
1171



killer T-cell-originated protein



kinase


P00492_C106
HPRT1 Hypoxanthine-guanine
1172



phosphoribosyltransferase


Q15631_C225
TSN Translin
1173


P52565_C79
ARHGDIA Rho GDP-
1174



dissociation inhibitor 1


P78417_C237
GSTO1 Glutathione S-
1175



transferase omega-1


Q01518_C93
CAP1 Adenylyl cyclase-
1176



associated protein 1


Q13148_C50
TARDBP TAR DNA-binding
1177



protein 43


P51665_C116
PSMD7 26S proteasome non-
1178



ATPase regulatory subunit 7


P17987_C147
TCP1 T-complex protein 1
1179



subunit alpha


O00299_C59
CLIC1 Chloride intracellular
1180



channel protein 1


P61077_C85
UBE2D3 Ubiquitin-
1181



conjugating enzyme E2 D3


Q06830_C173
PRDX1 Peroxiredoxin-1
1182


P06733_C389
ENO1 Alpha-enolase
1183


P28062_C120
PSMB8 Proteasome subunit
1184



beta type-8


Q96B23_C57
C18orf25 Uncharacterized
1185



protein C18orf25


P05388_C119
RPLP0 60S acidic ribosomal
1186



protein P0


Q14353_C91
GAMT Guanidinoacetate N-
1187



methyltransferase


P11142_C17
HSPA8 Heat shock cognate 71
1188



kDa protein


Q9UI30_C33
TRMT112 tRNA
1189



methyltransferase 112



homolog


P27348_C94
YWHAQ 14-3-3 protein theta
1190


P51812_C579
RPS6KA3 Ribosomal protein
1191



S6 kinase alpha-3


P62304_C46
SNRPE Small nuclear
1192



ribonucleoprotein E


P67936_C247
TPM4 Tropomyosin alpha-4
1193



chain


Q9H3P7_C129
ACBD3 Golgi resident protein
1194



GCP60


P49589_C27
CARS Cysteine--tRNA ligase,
1195



cytoplasmic


Q9BY32_C146
ITPA Inosine triphosphate
1196



pyrophosphatase


P25205_C360
MCM3 DNA replication
1197



licensing factor MCM3


Q96GX9_C147
APIP Probable
1198



methylthioribulose-1-



phosphate dehydratas


P18669_C153
PGAM1 Phosphoglycerate
1199



mutase 1


O75390_C211
CS Citrate synthase,
1200



mitochondrial


Q16555_C504
DPYSL2
1201



Dihydropyrimidinase-related



protein 2


P62993_C32
GRB2 Growth factor receptor-
1202



bound protein 2


P63104_C94
YWHAZ 14-3-3 protein
1203



zeta/delta


B0V043_C112
VARS Valyl-tRNA synthetase
1204


P62937_C161
PPIA Peptidyl-prolyl cis-trans
1205



isomerase A


Q8N806_C35
UBR7 Putative E3 ubiquitin-
1206



protein ligase UBR7


P10768_C56
ESD S-formylglutathione
1207



hydrolase


Q16630_C159
CPSF6 Cleavage and
1208



polyadenylation specificity



factor subunit


P47756_C147
CAPZB F-actin-capping
1209



protein subunit beta


Q9UMR2_C393
DDX19B ATP-dependent
1210



RNA helicase DDX19B


P00558_C379
PGK1 Phosphoglycerate
1211



kinase 1


Q9NZZ3_C20
CHMP5 Charged
1212



multivesicular body protein 5


P51610_C1886
HCFC1 Host cell factor 1
1213


P41250_C471
GARS Glycine-tRNA ligase
1214


O00299_C191
CLIC1 Chloride intracellular
1215



channel protein 1


Q9BV86_C195
NTMT1 N-terminal Xaa-Pro-
1216



Lys N-methyltransferase 1


Q15369_C112
TCEB1 Transcription
1217



elongation factor B



polypeptide 1


P14618_C49
PKM Pyruvate kinase
1218



isozymes M1/M2


O43707_C499
ACTN4 Alpha-actinin-4
1219


Q16576_C97
RBBP7 Histone-binding
1220



protein RBBP7


P28838_C462
LAP3 Cytosol aminopeptidase
1221


Q00839_C607
HNRNPU Heterogeneous
1222



nuclear ribonucleoprotein U


O95861_C42
BPNT1 3(2),5-bisphosphate
1223



nucleotidase 1


P40926_C212
MDH2 Malate dehydrogenase,
1224



mitochondrial


Q9Y2Z0_C62
SUGT1 Suppressor of G2
1225



allele of SKP1 homolog


O60828_C60
PQBP1 Polyglutamine-binding
1226



protein 1


P09661_C89
SNRPA1 U2 small nuclear
1227



ribonucleoprotein A


P63279_C138
UBE2I SUMO-conjugating
1228



enzyme UBC9


P62258_C98
YWHAE 14-3-3 protein
1229



epsilon


Q8WVJ2_C99
NUDCD2 NudC domain-
1230



containing protein 2


Q15365_C158
PCBP1 Poly(rC)-binding
1231



protein 1


P07900_C597
HSP90AA1 Heat shock protein
1232



HSP 90-alpha


P21333_C1157
FLNA Filamin-A
1233


P14618_C326
PKM Pyruvate kinase
1234



isozymes M1/M2


Q13363_C134
CTBP1 C-terminal-binding
1235



protein 1


P48643_C181
CCT5 T-complex protein 1
1236



subunit epsilon


P00338_C35
LDHA L-lactate
1237



dehydrogenase A chain


P25789_C107
PSMA4 Proteasome subunit
1238



alpha type-4


P28838_C335
LAP3 Cytosol aminopeptidase
1239


P00558_C316
PGK1 Phosphoglycerate
1240



kinase 1


Q9BQ69_C186
MACROD1 O-acetyl-ADP-
1241



ribose deacetylase MACROD1


P23368_C120
ME2 NAD-dependent malic
1242



enzyme, mitochondrial


P07195_C36
LDHB L-lactate
1243



dehydrogenase B chain


Q92879_C150
CELF1 CUGBP Elav-like
1244



family member 1


Q9Y696_C100
CLIC4 Chloride intracellular
1245



channel protein 4


Q8NBF2_C716
NHLRC2 NHL repeat-
1246



containing protein 2


P24534_C50
EEF1B2 Elongation factor 1-
1247



beta


P46782_C155
RPS5 40S ribosomal protein
1248



S5


H3BQZ7_C57
Uncharacterized protein
1249


Q93052_C364
LPP Lipoma-preferred partner
1250


P04075_C202
ALDOA Fructose-
1251



bisphosphate aldolase A


Q7KZF4_C560
SND1 Staphylococcal nuclease
1252



domain-containing protein


P40227_C406
CCT6A T-complex protein 1
1253



subunit zeta


P60174_C255
TPI1 Triosephosphate
1254



isomerase


Q08J23_C321
NSUN2 tRNA (cytosine(34)-
1255



C(5))-methyltransferase


P15927_C219
RPA2 Replication protein A 32
1256



kDa subunit


P09622_C477
DLD Dihydrolipoyl
1257



dehydrogenase, mitochondrial


P28838_C376
LAP3 Cytosol aminopeptidase
1258


P49915_C523
GMPS GMP synthase
1259


Q9H3H3_C222
C11orf68 UPF0696 protein
1260



C11orf68


P07737_C128
PFN1 Profilin-1
1261


Q00839_C594
HNRNPU Heterogeneous
1262



nuclear ribonucleoprotein U


Q14974_C455
KPNB1 Importin subunit beta-
1263



1


O15067_C66
PFAS
1264



Phosphoribosylformylglycinamidine



synthase


Q01813_C112
PFKP 6-phosphofructokinase
1265



type C


P11413_C385
G6PD Glucose-6-phosphate 1-
1266



dehydrogenase


Q13561_C240
DCTN2 Dynactin subunit 2
1267


Q13162_C245
PRDX4 Peroxiredoxin-4
1268


P50991_C252
CCT4 T-complex protein 1
1269



subunit delta


P04899_C112
GNAI2 Guanine nucleotide-
1270



binding protein G(i) subunit



alpha I2


O43765_C153
SGTA Small glutamine-rich
1271



tetratricopeptide repeat-



containing protein alpha


P34932_C290
HSPA4 Heat shock 70 kDa
1272



protein 4


P61247_C96
RPS3A 40S ribosomal protein
1273



S3a


P04075_C73
ALDOA Fructose-
1274



bisphosphate aldolase A


Q96EP5_C85
DAZAP1 DAZ-associated
1275



protein 1


P27708_C1889
CAD CAD protein
1276


Q16822_C431
PCK2 Phosphoenolpyruvate
1277



carboxykinase


Q96KB5_C70
PBK Lymphokine-activated
1278



killer T-cell-originated protein


P00558_C108
PGK1 Phosphoglycerate
1279



kinase 1


Q15365_C293
PCBP1 Poly(rC)-binding
1280



protein 1


P60174_C164
TPI1 Triosephosphate
1281



isomerase


P62826_C120
RAN GTP-binding nuclear
1282



protein Ran


O75348_C69
ATP6V1G1 V-type proton
1283



ATPase subunit G 1


Q9Y2D5_C296
AKAP2 A-kinase anchor
1284



protein 2


P61158_C12
ACTR3 Actin-related protein 3
1285


P36405_C118
ARL3 ADP-ribosylation
1286



factor-like protein 3


P62937_C115
PPIA Peptidyl-prolyl cis-trans
1287



isomerase A


P35754_C83
GLRX Glutaredoxin-1
1288


O60664_C341
PLIN3 Perilipin-3
1289


Q12874_C103
SF3A3 Splicing factor 3A
1290



subunit 3


Q9H4M9_C138
EHD1 EH domain-containing
1291



protein 1


Q15185_C76
PTGES3 Prostaglandin E
1292



synthase 3


P04632_C190
CAPNS1 Calpain small
1293



subunit 1


P13489_C75
RNH1 Ribonuclease inhibitor
1294


O95372_C213
LYPLA2 Acyl-protein
1295



thioesterase 2


P84085_C62
ARF5 ADP-ribosylation factor
1296



5


P55786_C265
NPEPPS Puromycin-sensitive
1297



aminopeptidase


Q14204_C1977
DYNC1H1 Cytoplasmic
1298



dynein 1 heavy chain 1


P14866_C581
HNRNPL Heterogeneous
1299



nuclear ribonucleoprotein L


Q14980_C160
NUMA1 Nuclear mitotic
1300



apparatus protein 1


O00743_C192
PPP6C Serine/threonine-
1301



protein phosphatase 6 catalytic



subunit


P07741_C83
APRT Adenine
1302



phosphoribosyltransferase


O75607_C105
NPM3 Nucleoplasmin-3
1303


P09429_C23
HMGB1 High mobility group
1304



protein B1


P26641_C339
EEF1G Elongation factor 1-
1305



gamma


O60232_C152
SSSCA1 Sjoegren
1306



syndrome/scleroderma



autoantigen 1


Q66K74_C342
MAP1S Microtubule-
1307



associated protein 1S


Q52LJ0_C63
FAM98B Protein FAM98B
1308


P62249_C25
RPS16 40S ribosomal protein
1309



S16


P35579_C988
MYH9 Myosin-9
1310


P33316_C222
DUT Deoxyuridine 5-
1311



triphosphate



nucleotidohydrolase,


Q9Y6E0_C89
STK24 Serine/threonine-
1312



protein kinase 24


P49411_C222
TUFM Elongation factor Tu,
1313



mitochondrial


Q01813_C360
PFKP 6-phosphofructokinase
1314



type C


Q7L2J0_C177
MEPCE 7SK snRNA
1315



methylphosphate capping



enzyme


O15355_C164
PPM1G Protein phosphatase
1316



1G


Q6IBS0_C141
TWF2 Twinfilin-2
1317


Q9NVG8_C387
TBC1D13 TBC1 domain
1318



family member 13


O15382_C342
BCAT2 Branched-chain-
1319



amino-acid aminotransferase,



mitochandrial


P12004_C135
PCNA Proliferating cell
1320



nuclear antigen


P60660_C32
MYL6 Myosin light
1321



polypeptide 6


P55072_C522
VCP Transitional endoplasmic
1322



reticulum ATPase


Q99439_C240
CNN2 Calponin-2
1323


P05455_C245
SSB Lupus La protein
1324


O75131_C54
CPNE3 Copine-3
1325


P26358_C62
DNMT1 DNA (cytosine-5)-
1326



methyltransferase 1


Q7Z4W1_C138
DCXR L-xylulose reductase
1327


P10809_C447
HSPD1 60 kDa heat shock
1328



protein, mitochondrial


P84077_C159
ARF1 ADP-ribosylation factor
1329



1


Q15185_C40
PTGES3 Prostaglandin E
1330



synthase 3


Q16854_C87
DGUOK Deoxyguanosine
1331



kinase, mitochondrial


Q9Y508_C8
RNF114 RING finger protein
1332



114


P63208_C120
SKP1 S-phase kinase-
1333



associated protein 1


O00148_C164
DDX39A ATP-dependent
1334



RNA helicase DDX39A


P25786_C148
PSMA1 Proteasome subunit
1335



alpha type-1


P61221_C88
ABCE1 ATP-binding cassette
1336



sub-family E member 1


O60664_C60
PLIN3 Perilipin-3
1337


P15311_C117
EZR Ezrin
1338


Q9UBW8_C110
COPS7A COP9 signalosome
1339



complex subunit 7a


P42765_C287
ACAA2 3-ketoacyl-CoA
1340



thiolase, mitochondrial


Q99832_C158
CCT7 T-complex protein 1
1341



subunit eta


P61978_C145
HNRNPK Heterogeneous
1342



nuclear ribonucleoprotein K


Q13310_C132
PABPC4 Polyadenylate-
1343



binding protein 4


P35998_C377
PSMC2 26S protease
1344



regulatory subunit 7


P52789_C794
HK2 Hexokinase-2
1345


P35579_C91
MYH9 Myosin-9
1346


P13995_C166
MTHFD2 Bifunctional
1347



methylenetetrahydrofolate



dehydrogena


P22102_C41
GART Trifunctional purine
1348



biosynthetic protein adenosin


P0CW22_C35
RPS17L 40S ribosomal protein
1349



S17-like


Q9UK45_C85
LSM7 U6 snRNA-associated
1350



Sm-like protein LSm7


Q12874_C274
SF3A3 Splicing factor 3A
1351



subunit 3


P34897_C119
SHMT2 Serine
1352



hydroxymethyltransferase,



mitochondrial


P15153_C157
RAC2 Ras-related C3
1353



botulinum toxin substrate 2


Q16186_C88
ADRM1 Proteasomal ubiquitin
1354



receptor ADRM1


P15531_C145
NME1 Nucleoside diphosphate
1355



kinase A


P49327_C2202
FASN Fatty acid synthase
1356


P40926_C275
MDH2 Malate dehydrogenase,
1357



mitochondrial


P22314_C23
UBA1 Ubiquitin-like modifier-
1358



activating enzyme 1


P52789_C517
HK2 Hexokinase-2
1359


Q12931_C573
TRAP1 Heat shock protein 75
1360



kDa, mitochondrial


P39687_C123
ANP32A Acidic leucine-rich
1361



nuclear phosphoprotein 32



fami


O43865_C272
AHCYL1 Putative
1362



adenosylhomocysteinase 2


O95456_C157
PSMG1 Proteasome assembly
1363



chaperone 1


P49005_C384
POLD2 DNA polymerase delta
1364



subunit 2


Q96EY8_C132
MMAB Cob(I)yrinic acid a,c-
1365



diamide adenosyltransferase,


P28074_C111
PSMB5 Proteasome subunit
1366



beta type-5


O75446_C184
SAP30 Histone deacetylase
1367



complex subunit SAP30


P05388_C27
RPLP0 60S acidic ribosomal
1368



protein P0


Q15366_C158
PCBP2 Poly(rC)-binding
1369



protein 2


O75369_C2501
FLNB Filamin-B
1370


Q06124_C259
PTPN11 Tyrosine-protein
1371



phosphatase non-receptor type



11


P40926_C285
MDH2 Malate dehydrogenase,
1372



mitochondrial


Q9BV79_C263
MECR Trans-2-enoyl-CoA
1373



reductase, mitochondrial


Q09666_C1900
AHNAK Neuroblast
1374



differentiation-associated



protein AHNA


Q9UBB5_C359
MBD2 Methyl-CpG-binding
1375



domain protein 2


P32322_C262
PYCR1 Pyrroline-5-
1376



carboxylate reductase 1,



mitochondrial


P31939_C241
ATIC Bifunctional purine
1377



biosynthesis protein PURH


Q04917_C97
YWHAH 14-3-3 protein eta
1378


P62753_C100
RPS6 40S ribosomal protein
1379



S6


Q9Y490_C1353
TLN1 Talin-1
1380


P52701_C615
MSH6 DNA mismatch repair
1381



protein Msh6


P49591_C300
SARS Serine--tRNA ligase,
1382



cytoplasmic


P49411_C127
TUFM Elongation factor Tu,
1383



mitochondrial


P51610_C227
HCFC1 Host cell factor 1
1384


P60174_C104
TPI1 Triosephosphate
1385



isomerase


Q12982_C295
BNIP2 BCL2/adenovirus E1B
1386



19 kDa protein-interacting pro


Q9UHD8_C375
SEPT9 Septin-9
1387


P53618_C888
COPB1 Coatomer subunit beta
1388


Q8N163_C644
KIAA1967 DBIRD complex
1389



subunit KIAA1967


P61106_C40
RAB14 Ras-related protein
1390



Rab-14


P21291_C167
CSRP1 Cysteine and glycine-
1391



rich protein 1


Q07020_C134
RPL18 60S ribosomal protein
1392



L18


Q86VP6_C413
CAND1 Cullin-associated
1393



NEDD8-dissociated protein 1


Q9Y3F4_C305
STRAP Serine-threonine
1394



kinase receptor-associated



protein


Q9Y5K6_C540
CD2AP CD2-associated
1395



protein


O60361_C130
NME2P1 Putative nucleoside
1396



diphosphate kinase


Q9BWD1_C65
ACAT2 Acetyl-CoA
1397



acetyltransferase, cytosolic


Q7L2J0_C522
MEPCE 7SK snRNA
1398



methylphosphate capping



enzyme


P61158_C307
ACTR3 Actin-related protein 3
1399


P11142_C603
HSPA8 Heat shock cognate 71
1400



kDa protein


P13639_C728
EEF2 Elongation factor 2
1401


P04183_C206
TK1 Thymidine kinase,
1402



cytosolic


P30153_C294
PPP2R1A Serine/threonine-
1403



protein phosphatase 2A 65 kDa



regulatory subunit A


Q09666_C2162
AHNAK Neuroblast
1404



differentiation-associated



protein AHNA


P46779_C13
RPL28 60S ribosomal protein
1405



L28


Q9Y696_C234
CLIC4 Chloride intracellular
1406



channel protein 4


P08670_C328
VIM Vimentin
1407


O43684_C129
BUB3 Mitotic checkpoint
1408



protein BUB3


Q04917_C112
YWHAH 14-3-3 protein eta
1409


P41252_C526
IARS Isoleucine-tRNA ligase,
1410



cytoplasmic


O14980_C1070
XPO1 Exportin-1
1411


Q9Y3D5_C90
MRPS18C 28S ribosomal
1412



protein S18c, mitochondrial


Q15459_C244
SF3A1 Splicing factor 3A
1413



subunit 1


P50552_C334
VASP Vasodilator-stimulated
1414



phosphoprotein


Q04637_C1265
EIF4G1 Eukaryotic translation
1415



initiation factor 4 gamma 1


Q12824_C147
SMARCB1 SWI/SNF-related
1416



matrix-associated actin-



dependent


P78346_C87
RPP30 Ribonuclease P protein
1417



subunit p30


Q99460_C806
PSMD1 26S proteasome non-
1418



ATPase regulatory subunit 1


P46060_C573
RANGAP1 Ran GTPase-
1419



activating protein 1


Q6P1X6_C98
C8orf82 UPF0598 protein
1420



C8orf82


P49189_C484
ALDH9A1 4-
1421



trimethylaminobutyraldehyde



dehydrogenase


Q9NVG8_C36
TBC1D13 TBC1 domain
1422



family member 13


P49841_C199
GSK3B Glycogen synthase
1423



kinase-3 beta


Q09666_C1833
AHNAK Neuroblast
1424



differentiation-associated



protein AHNA


P62241_C182
RPS8 40S ribosomal protein
1425



S8


Q13620_C787
CUL4B Cullin-4B
1426


P26599_C23
PTBP1 Polypyrimidine tract-
1427



binding protein 1


Q14697_C502
GANAB Neutral alpha-
1428



glucosidase AB


P08238_C564
HSP90AB1 Heat shock protein
1429



HSP 90-beta


P53582_C14
METAP1 Methionine
1430



aminopeptidase 1


Q9UBT2_C30
UBA2 SUMO-activating
1431



enzyme subunit 2


P06733_C119
ENO1 Alpha-enolase
1432


P55884_C384
EIF3B Eukaryotic translation
1433



initiation factor 3 subunit


P63167_C24
DYNLL1 Dynein light chain 1,
1434



cytoplasmic


Q15417_C173
CNN3 Calponin-3
1435


P21980_C230
TGM2 Protein-glutamine
1436



gamma-glutamyltransferase 2


P31943_C122
HNRNPH1 Heterogeneous
1437



nuclear ribonucleoprotein H


P31947_C38
SFN 14-3-3 protein sigma
1438


P18085_C159
ARF4 ADP-ribosylation factor
1439



4


P60174_C124
TPI1 Triosephosphate
1440



isomerase


P14618_C152
PKM Pyruvate kinase
1441



isozymes M1/M2


Q12765_C324
SCRN1 Secernin-1
1442


Q16555_C179
DPYSL2
1443



Dihydropyrimidinase-related



protein 2


P35579_C1379
MYH9 Myosin-9
1444


P07814_C92
EPRS Bifunctional
1445



glutamate/proline--tRNA



ligase


Q92597_C168
NDRG1 Protein NDRG1
1446


O43707_C351
ACTN4 Alpha-actinin-4
1447


Q7RTV0_C49
PHF5A PHD finger-like
1448



domain-containing protein 5A


P53396_C845
ACLY ATP-citrate synthase
1449


P17844_C234
DDX5 Probable ATP-
1450



dependent RNA helicase



DDX5


Q9H0C8_C325
ILKAP Integrin-linked kinase-
1451



associated serine/threonine


P11413_C446
G6PD Glucose-6-phosphate 1-
1452



dehydrogenase


Q9BTT0_C87
ANP32E Acidic leucine-rich
1453



nuclear phosphoprotein 32



family member #


Q14258_C70
TRIM25 E3 ubiquitin/ISG15
1454



ligase TRIM25


Q8WU79_C196
SMAP2 Stromal membrane-
1455



associated protein 2


Q92947_C289
GCDH Glutaryl-CoA
1456



dehydrogenase, mitochondrial


P45974_C195
USP5 Ubiquitin carboxyl-
1457



terminal hydrolase 5


Q9BXJ9_C817
NAA15 N-alpha-
1458



acetyltransferase 15, NatA



auxiliary subun


P62330_C155
ARF6 ADP-ribosylation factor
1459



6


Q13501_C27
SQSTM1 Sequestosome-1
1460


Q5VWZ2_C12
LYPLAL1
1461



Lysophospholipase-like



protein 1


Q04206_C105
RELA Transcription factor p65
1462


P36551_C198
CPOX Coproporphyrinogen-
1463



III oxidase, mitochondrial


P25398_C69
RPS12 40S ribosomal protein
1464



S12


Q00839_C648
HNRNPU Heterogeneous
1465



nuclear ribonucleoprotein U


P24752_C142
ACAT1 Acetyl-CoA
1466



acetyltransferase,



mitochondrial


P02545_C522
LMNA Prelamin-A/C
1467


O60763_C678
USO1 General vesicular
1468



transport factor p115


P04637_C182
TP53 Cellular tumor antigen
1469



p53


Q9UHX1_C129
PUF60 Poly(U)-binding-
1470



splicing factor PUF60


Q9Y383_C348
LUC7L2 Putative RNA-
1471



binding protein Luc7-like 2


P78371_C289
CCT2 T-complex protein 1
1472



subunit beta


Q15149_C4494
PLEC Plectin
1473


P13639_C369
EEF2 Elongation factor 2
1474


P61163_C34
ACTR1A Alpha-centractin
1475


Q7Z2W4_C645
ZC3HAV1 Zinc finger CCCH-
1476



type antiviral protein 1


P23526_C421
AHCY
1477



Adenosylhomocysteinase


Q9P2T1_C348
GMPR2 GMP reductase 2
1478


Q12849_C476
GRSF1 G-rich sequence factor
1479



1


P07814_C744
EPRS Bifunctional
1480



glutamate/proline--tRNA



ligase


Q9ULA0_C327
DNPEP Aspartyl
1481



aminopeptidase


Q01081_C67
U2AF1 Splicing factor U2AF
1482



35 kDa subunit


P53041_C11
PPP5C Serine/threonine-
1483



protein phosphatase 5


P63244_C138
GNB2L1 Guanine nucleotide-
1484



binding protein subunit beta-2-


Q06323_C106
PSME1 Proteasome activator
1485



complex subunit 1


O95071_C730
UBR5 E3 ubiquitin-protein
1486



ligase UBR5


Q9H0D6_C736
XRN2 5-3 exoribonuclease 2
1487


P00558_C50
PGK1 Phosphoglycerate
1488



kinase 1


P52272_C114
HNRNPM Heterogeneous
1489



nuclear ribonucleoprotein M


Q92598_C34
HSPH1 Heat shock protein 105
1490



kDa


P51858_C12
HDGF Hepatoma-derived
1491



growth factor


Q9UBN7_C426
HDAC6 Histone deacetylase 6
1492


P09234_C25
SNRPC U1 small nuclear
1493



ribonucleoprotein C


Q9P1F3_C39
ABRACL Costars family
1494



protein ABRACL


P61158_C34
ACTR3 Actin-related protein 3
1495


P13639_C812
EEF2 Elongation factor 2
1496


B0V043_C41
VARS Valyl-tRNA synthetase
1497


Q9NQT5_C215
EXOSC3 Exosome complex
1498



component RRP40


Q6PJG6_C539
BRAT1 BRCA1-associated
1499



ATM activator 1


H3BN98_C196
Uncharacterized protein
1500


P35998_C389
PSMC2 26S protease
1501



regulatory subunit 7


P41250_C616
GARS Glycine--tRNA ligase
1502


Q9Y5Y2_C269
NUBP2 Cytosolic Fe—S cluster
1503



assembly factor NUBP2


P31948_C26
STIP1 Stress-induced-
1504



phosphoprotein 1


Q99575_C705
POP1 Ribonucleases P/MRP
1505



protein subunit POP1


O00429_C470
DNM1L Dynamin-1-like
1506



protein


O43264_C568
ZW10 Centromere/kinetochore
1507



protein zw10 homolog


Q99961_C277
SH3GL1 Endophilin-A2
1508


Q99460_C898
PSMD1 26S proteasome non-
1509



ATPase regulatory subunit 1


P49411_C290
TUFM Elongation factor Tu,
1510



mitochondrial


P21980_C370
TGM2 Protein-glutamine
1511



gamma-glutamyltransferase 2


P21980_C545
TGM2 Protein-glutamine
1512



gamma-glutamyltransferase 2


O00273_C154
DFFA DNA fragmentation
1513



factor subunit alpha


P09936_C152
UCHL1 Ubiquitin carboxyl-
1514



terminal hydrolase isozyme L1


Q66K74_C440
MAP1S Microtubule-
1515



associated protein 1S


Q9Y305_C155
ACOT9 Acyl-coenzyme A
1516



thioesterase 9, mitochondrial


P17655_C105
CAPN2 Calpain-2 catalytic
1517



subunit


P17655_C301
CAPN2 Calpain-2 catalytic
1518



subunit


P35611_C525
ADD1 Alpha-adducin
1519


P14625_C645
HSP90B1 Endoplasmin
1520


O95571_C34
ETHE1 Protein ETHE1,
1521



mitochondrial


P62241_C100
RPS8 40S ribosomal protein
1522



S8


P22061_C95
PCMT1 Protein-L-
1523



isoaspartate(D-aspartate) O-



methyltransferase


P19367_C813
HK1 Hexokinase-1
1524


P20073_C363
ANXA7 Annexin A7
1525


O95486_C704
SEC24A Protein transport
1526



protein Sec24A


P27816_C535
MAP4 Microtubule-associated
1527



protein 4


Q08J23_C93
NSUN2 tRNA (cytosine(34)-
1528



C(5))-methyltransferase


Q9NSD9_C195
FARSB Phenylalanine--tRNA
1529



ligase beta subunit


Q9GZZ9_C250
UBA5 Ubiquitin-like modifier-
1530



activating enzyme 5


P41240_C290
CSK Tyrosine-protein kinase
1531



CSK


P00492_C23
HPRT1 Hypoxanthine-guanine
1532



phosphoribosyltransferase


Q99714_C58
HSD17B10 3-hydroxyacyl-
1533



CoA dehydrogenase type-2


P27707_C59
DCK Deoxycytidine kinase
1534


P19784_C336
CSNK2A2 Casein kinase II
1535



subunit alpha


P50914_C42
RPL14 60S ribosomal protein
1536



L14


Q8WVJ2_C14
NUDCD2 NudC domain-
1537



containing protein 2


Q02543_C22
RPL18A 60S ribosomal
1538



protein L18a


Q6YN16_C218
HSDL2 Hydroxysteroid
1539



dehydrogenase-like protein 2


Q9UHD8_C248
SEPT9 Septin-9
1540


P22314_C1040
UBA1 Ubiquitin-like modifier-
1541



activating enzyme 1


Q15020_C670
SART3 Squamous cell
1542



carcinoma antigen recognized



by T-cells 3


O15144_C120
ARPC2 Actin-related protein
1543



2/3 complex subunit 2


Q9UNM6_C357
PSMD13 26S proteasome non-
1544



ATPase regulatory subunit 13


P30040_C157
ERP29 Endoplasmic reticulum
1545



resident protein 29


Q96Q11_C373
TRNT1 CCA tRNA
1546



nucleotidyltransferase 1,



mitochondrial


Q02750_C277
MAP2K1 Dual specificity
1547



mitogen-activated protein



kinase


P27816_C635
MAP4 Microtubule-associated
1548



protein 4


Q13185_C69
CBX3 Chromobox protein
1549



homolog 3


P21291_C40
CSRP1 Cysteine and glycine-
1550



rich protein 1


P55072_C535
VCP Transitional endoplasmic
1551



reticulum ATPase


P55072_C572
VCP Transitional endoplasmic
1552



reticulum ATPase


P39687_C87
ANP32A Acidic leucine-rich
1553



nuclear phosphoprotein 32



family


Q9Y314_C8
NOSIP Nitric oxide synthase-
1554



interacting protein


Q9UBT2_C173
UBA2 SUMO-activating
1555



enzyme subunit 2


P34897_C91
SHMT2 Serine
1556



hydroxymethyltransferase,



mitochondrial


O00299_C178
CLIC1 Chloride intracellular
1557



channel protein 1


Q9Y570_C238
PPME1 Protein phosphatase
1558



methylesterase 1


P61927_C19
RPL37 60S ribosomal protein
1559



L37


O75153_C1196
KIAA0664 Clustered
1560



mitochondria protein homolog


P23919_C31
DTYMK Thymidylate kinase
1561


P40121_C290
CAPG Macrophage-capping
1562



protein


A0AVT1_C433
UBA6 Ubiquitin-like modifier-
1563



activating enzyme 6


Q15365_C201
PCBP1 Poly(rC)-binding
1564



protein 1


P29401_C386
TKT Transketolase
1565


P48147_C25
PREP Prolyl endopeptidase
1566


Q01813_C411
PFKP 6-phosphofructokinase
1567



type C


P21333_C2543
FLNA Filamin-A
1568


P21333_C2601
FLNA Filamin-A
1569


O00154_C288
ACOT7 Cytosolic acyl
1570



coenzyme A thioester



hydrolase


P27635_C195
RPL10 60S ribosomal protein
1571



L10


P26038_C117
MSN Moesin
1572


Q96HE7_C208
ERO1L ERO1-like protein
1573



alpha


P12814_C480
ACTN1 Alpha-actinin-1
1574


P07203_C202
GPX1 Glutathione peroxidase
1575



1


Q99497_C46
PARK7 Protein DJ-1
1576


Q9HAV4_C1131
XPO5 Exportin-5
1577


Q9UJX3_C131
ANAPC7 Anaphase-promoting
1578



complex subunit 7


O75821_C139
EIF3G Eukaryotic translation
1579



initiation factor 3 subunit


P00338_C131
LDHA L-lactate
1580



dehydrogenase A chain


Q15102_C55
PAFAH1B3 Platelet-activating
1581



factor acetylhydrolase IB subu


Q1KMD3_C308
HNRNPUL2 Heterogeneous
1582



nuclear ribonucleoprotein U-



like protein 2


P54886_C88
ALDH18A1 Delta-1-pyrroline-
1583



5-carboxylate synthase


Q5VSL9_C798
FAM40A Protein FAM40A
1584


P30084_C213
ECHS1 Enoyl-CoA hydratase,
1585



mitochondrial


P30086_C168
PEBP1
1586



Phosphatidylethanolamine-



binding protein 1


Q9Y3D0_C158
FAM96B Mitotic spindle-
1587



associated MMXD complex



subunit MI


P49589_C204
CARS Cysteine--tRNA ligase,
1588



cytoplasmic


Q15366_C217
PCBP2 Poly(rC)-binding
1589



protein 2


O75369_C2556
FLNB Filamin-B
1590


Q16181_C126
SEPT7 Septin-7
1591


Q99661_C245
KIF2C Kinesin-like protein
1592



KIF2C


Q9UHD1_C86
CHORDC1 Cysteine and
1593



histidine-rich domain-



containing protein


P0CB43_C368
FAM203B Protein FAM203B
1594


P40925_C137
MDH1 Malate dehydrogenase,
1595



cytoplasmic


Q12888_C1933
TP53BP1 Tumor suppressor
1596



p53-binding protein 1


Q14247_C112
CTTN Src substrate cortactin
1597


Q13200_C251
PSMD2 26S proteasome non-
1598



ATPase regulatory subunit 2


P13639_C591
EEF2 Elongation factor 2
1599


P27816_C126
MAP4 Microtubule-associated
1600



protein 4


P48739_C187
PITPNB Phosphatidylinositol
1601



transfer protein beta isoform


P14866_C472
HNRNPL Heterogeneous
1602



nuclear ribonucleoprotein L


P07237_C343
P4HB Protein disulfide-
1603



isomerase


O43708_C205
GSTZ1 Maleylacetoacetate
1604



isomerase


P19623_C25
SRM Spermidine synthase
1605


P56537_C56
EIF6 Eukaryotic translation
1606



initiation factor 6


Q96SW2_C188
CRBN Protein cereblon
1607


P41240_C31
CSK Tyrosine-protein kinase
1608



CSK


P36551_C127
CPOX Coproporphyrinogen-
1609



III oxidase, mitochondrial


P52292_C133
KPNA2 Importin subunit
1610



alpha-2


Q04637_C1516
EIF4G1 Eukaryotic translation
1611



initiation factor 4 gamma 1


P60981_C80
DSTN Destrin
1612


Q7RTV0_C40
PHF5A PHD finger-like
1613



domain-containing protein 5A


P19838_C61
NFKB1 Nuclear factor NF-
1614



kappa-B p105 subunit


P53396_C633
ACLY ATP-citrate synthase
1615


P49207_C83
RPL34 60S ribosomal protein
1616



L34


Q14974_C689
KPNB1 Importin subunit beta-
1617



1


Q96I99_C162
SUCLG2 Succinyl-CoA ligase
1618


P51610_C1139
HCFC1 Host cell factor 1
1619


Q14657_C23
LAGE3 L antigen family
1620



member 3


P13639_C290
EEF2 Elongation factor 2
1621


P22314_C481
UBA1 Ubiquitin-like modifier-
1622



activating enzyme 1


Q52LJ0_C295
FAM98B Protein FAM98B
1623


Q7Z2W4_C38
ZC3HAV1 Zinc finger CCCH-
1624



type antiviral protein 1


P26447_C81
S100A4 Protein S100-A4
1625


P30041_C47
PRDX6 Peroxiredoxin-6
1626


P04040_C377
CAT Catalase
1627


Q14847_C20
LASP1 LIM and SH3 domain
1628



protein 1


P55209_C88
NAP1L1 Nucleosome
1629



assembly protein 1-like 1


Q9NRP4_C80
ACN9 Protein ACN9
1630



homolog, mitochondrial


P17987_C385
TCP1 T-complex protein 1
1631



subunit alpha


P13797_C104
PLS3 Plastin-3
1632


Q7Z434_C33
MAVS Mitochondrial
1633



antiviral-signaling protein


P49915_C489
GMPS GMP synthase K
1634


Q9H814_C51
PHAX Phosphorylated adapter
1635



RNA export protein


Q15181_C274
PPA1 Inorganic
1636



pyrophosphatase


Q9UPN7_C795
PPP6R1 Serine/threonine-
1637



protein phosphatase 6



regulatory


P50395_C202
GDI2 Rab GDP dissociation
1638



inhibitor beta


P27695_C296
APEX1 DNA-(apurinic or
1639



apyrimidinic site) lyase


P13010_C493
XRCC5 X-ray repair cross-
1640



complementing protein 5


P27635_C49
RPL10 60S ribosomal protein
1641



L10


Q9BZE9_C109
ASPSCR1 Tether containing
1642



UBX domain for GLUT4


P43487_C99
RANBP1 Ran-specific
1643



GTPase-activating protein


P78527_C1904
PRKDC DNA-dependent
1644



protein kinase catalytic subunit


Q6JBY9_C155
RCSD1 CapZ-interacting
1645



protein


P14625_C576
HSP90B1 Endoplasmin
1646


Q8N806_C260
UBR7 Putative E3 ubiquitin-
1647



protein ligase UBR7


Q9GZT9_C127
EGLN1 Egl nine homolog 1
1648


P06744_C404
GPI Glucose-6-phosphate
1649



isomerase


P00390_C102
GSR Glutathione reductase,
1650



mitochondrial


P25398_C106
RPS12 40S ribosomal protein
1651



S12


Q00839_C497
HNRNPU Heterogeneous
1652



nuclear ribonucleoprotein U


P49368_C455
CCT3 T-complex protein 1
1653



subunit gamma


P33993_C482
MCM7 DNA replication
1654



licensing factor MCM7


P57764_C191
GSDMD Gasdermin-D
1655


P40222_C523
TXLNA Alpha-taxilin
1656


Q9NTZ6_C887
RBM12 RNA-binding protein
1657



12


Q9Y617_C80
PSAT1 Phosphoserine
1658



aminotransferase


P27695_C99
APEX1 DNA-(apurinic or
1659



apyrimidinic site) lyase


Q7Z6Z7_C3239
HUWE1 E3 ubiquitin-protein
1660



ligase HUWE1


Q16644_C203
MAPKAPK3 MAP kinase-
1661



activated protein kinase 3


O15355_C13
PPM1G Protein phosphatase
1662



1G


Q15149_C3821
PLEC Plectin
1663


O94776_C209
MTA2 Metastasis-associated
1664



protein MTA2


A6NHG4_C24
DDTL D-dopachrome
1665



decarboxylase-like protein


P356I1_C430
ADD1 Alpha-adducin
1666


Q9NVA2_C41
SEPT11 Septin-11
1667


P19404_C225
NDUFV2 NADH
1668



dehydrogenase


P35579_C569
MYH9 Myosin-9
1669


P19367_C834
HK1 Hexokinase-1
1670


P30041_C91
PRDX6 Peroxiredoxin-6
1671


P21281_C162
ATP6V1B2 V-type proton
1672



ATPase subunit B, brain



isoform


P13796_C42
LCP1 Plastin-2
1673


O00410_C687
IPO5 Importin-5
1674


P49207_C49
RPL34 60S ribosomal protein
1675



L34


P35658_C186
NUP214 Nuclear pore
1676



complex protein Nup214


P17858_C170
PFKL 6-phosphofructokinase,
1677



liver type


P21333_C574
FLNA Filamin-A
1678


O60701_C241
UGDH UDP-glucose 6-
1679



dehydrogenase


Q15691_C228
MAPRE1 Microtubule-
1680



associated protein RP/EB



family member


P31153_C104
MAT2A S-
1681



adenosylmethionine synthase



isoform type-2


Q14247_C246
CTTN Src substrate cortactin
1682


Q8IWX8_C69
CHERP Calcium homeostasis
1683



endoplasmic reticulum protein


Q99543_C394
DNAJC2 DnaJ homolog
1684



subfamily C member 2


Q6JBY9_C181
RCSD1 CapZ-interacting
1685



protein


P12814_C41
ACTN1 Alpha-actinin-1
1686


P17812_C491
CTPS1 CTP synthase 1
1687


E7ETI0_C21
ARPC4-TTLL3 Protein
1688



ARPC4-TTLL3


Q9ULC4_C14
MCTS1 Malignant T-cell-
1689



amplified sequence 1


P08134_C16
RHOC Rho-related GTP-
1690



binding protein RhoC


Q14980_C80
NUMA1 Nuclear mitotic
1691



apparatus protein 1


Q9NYL9_C231
TMOD3 Tropomodulin-3
1692


Q99439_C61
CNN2 Calponin-2
1693


P46776_C144
RPL27A 60S ribosomal
1694



protein L27a


O14980_C164
XPO1 Exportin-1
1695


Q9Y2L1_C213
DIS3 Exosome complex
1696



exonuclease RRP44


O60502_C596
MGEA5 Bifunctional protein
1697



NCOAT


P49748_C237
ACADVL Very long-chain
1698



specific acyl-CoA



dehydrogenase, mitochondrial


O76003_C146
GLRX3 Glutaredoxin-3
1699


P27797_C163
CALR Calreticulin
1700


P49368_C279
CCT3 T-complex protein 1
1701



subunit gamma


P32119_C172
PRDX2 Peroxiredoxin-2
1702


O15541_C15
RNF113A RING finger protein
1703



113A


Q15417_C59
CNN3 Calponin-3
1704


P60981_C135
DSTN Destrin
1705


P36776_C682
LONP1 Lon protease homolog,
1706



mitochondrial


P13693_C28
TPT1 Translationally-
1707



controlled tumor protein


B5ME19_C444
EIF3CL Eukaryotic translation
1708



initiation factor 3 subunit


Q93009_C223
USP7 Ubiquitin carboxyl-
1709



terminal hydrolase 7


Q9UPQ0_C669
LIMCH1 LIM and calponin
1710



homology domains-containing



prote


Q96EY4_C162
TMA16 Translation
1711



machinery-associated protein



16


Q9BSH5_C243
HDHD3 Haloacid
1712



dehalogenase-like hydrolase



domain-contai


Q99832_C450
CCT7 T-complex protein I
1713



subunit eta


P68366_C129
TUBA4A Tubulin alpha-4A
1714



chain


Q6IS14_C73
EIF5AL1 Eukaryotic
1715



translation initiation factor 5A-



1-like


P52907_C157
CAPZA1 F-actin-capping
1716



protein subunit alpha-1


P78527_C25
PRKDC DNA-dependent
1717



protein kinase catalytic subunit


O43592_C650
XPOT Exportin-T
1718


P49459_C88
UBE2A Ubiquitin-conjugating
1719



enzyme E2 A


Q9UEW8_C237
STK39 STE20/SPS1-related
1720



proline-alanine-rich protein ki


Q92888_C537
ARHGEF1 Rho guanine
1721



nucleotide exchange factor 1


P17812_C362
CTPS1 CTP synthase 1
1722


Q8IY67_C255
RAVER1 Ribonucleoprotein
1723



PTB-binding 1


Q13547_C408
HDAC1 Histone deacetylase 1
1724


P00505_C106
GOT2 Aspartate
1725



aminotransferase,



mitochondrial


P35579_C816
MYH9 Myosin-9
1726


O00148_C197
DDX39A ATP-dependent
1727



RNA helicase DDX39A


Q14192_C150
FHL2 Four and a half LIM
1728



domains protein 2


Q14204_C633
DYNC1H1 Cytoplasmic
1729



dynein 1 heavy chain 1


P07814_C1487
EPRS Bifunctional
1730



glutamate/proline--tRNA



ligase


P27816_C1098
MAP4 Microtubule-associated
1731



protein 4


P61586_C107
RHOA Transforming protein
1732



RhoA


Q08J23_C673
NSUN2 tRNA (cytosine(34)-
1733



C(5))-methyltransferase


P53041_C77
PPP5C Serine/threonine-
1734



protein phosphatase 5


O43707_C173
ACTN4 Alpha-actinin-4
1735


Q06210_C55
GFPT1 Glucosamine--
1736



fructose-6-phosphate



aminotransferase


P06400_C853
RB1 Retinoblastoma-
1737



associated protein


Q9BUJ2_C391
HNRNPUL1 Heterogeneous
1738



nuclear ribonucleoprotein U-



like protein


E7EVH7_C286
KLC1 Kinesin light chain 1
1739


Q68CZ2_C1241
TNS3 Tensin-3
1740


Q9Y5Y2_C72
NUBP2 Cytosolic Fe—S cluster
1741



assembly factor NUBP2


P11498_C850
PC Pyruvate carboxylase,
1742



mitochondrial


Q9BXS6_C256
NUSAP1 Nucleolar and
1743



spindle-associated protein 1


P56192_C38
MARS Methionine--tRNA
1744



ligase, cytoplasmic


P35914_C323
HMGCL
1745



Hydroxymethylglutaryl-CoA



lyase, mitochondrial


P00367_C172
GLUD1 Glutamate
1746



dehydrogenase 1,



mitochondrial


Q99873_C350
PRMT1 Protein arginine N-
1747



methyltransferase 1


P15170_C276
GSPT1 Eukaryotic peptide
1748



chain release factor GTP-



bindin


Q13838_C165
DDX39B Spliceosome RNA
1749



helicase DDX39B


O75369_C1617
FLNB Filamin-B
1750


Q96RU3_C609
FNBP1 Formin-binding
1751



protein 1


P16333_C266
NCK1 Cytoplasmic protein
1752



NCK1


P35250_C88
RFC2 Replication factor C
1753



subunit 2


Q9BSD7_C184
NTPCR Cancer-related
1754



nucleoside-triphosphatase


P13489_C142
RNH1 Ribonuclease inhibitor
1755


P26639_C343
TARS Threonine--tRNA
1756



ligase, cytoplasmic


P31153_C56
MAT2A S-
1757



adenosylmethionine synthase



isoform type-2


P01591_C131
IGJ Immunoglobulin J chain
1758


P07858_C93
CTSB Cathepsin B
1759


P62191_C399
PSMC1 26S protease
1760



regulatory subunit 4


P85037_C439
FOXK1 Forkhead box protein
1761



K1


Q96EY7_C642
PTCD3 Pentatricopeptide
1762



repeat-containing protein 3,



mitochondrial


P78417_C192
GSTO1 Glutathione S-
1763



transferase omega-1


O75694_C704
NUP155 Nuclear pore
1764



complex protein Nup155


Q9NZD2_C36
GLTP Glycolipid transfer
1765



protein


Q9NR45_C287
NANS Sialic acid synthase
1766


P52788_C318
SMS Spermine synthase
1767


P52788_C337
SMS Spermine synthase
1768


P37837_C250
TALDO1 Transaldolase
1769


Q9UBB4_C283
ATXN10 Ataxin-10
1770


Q14204_C1888
DYNC1H1 Cytoplasmic
1771



dynein 1 heavy chain 1


P14866_C452
HNRNPL Heterogeneous
1772



nuclear ribonucleoprotein L


P56537_C15
EIF6 Eukaryotic translation
1773



initiation factor 6


Q9Y5Y2_C54
NUBP2 Cytosolic Fe—S cluster
1774



assembly factor NUBP2


P28838_C445
LAP3 Cytosol aminopeptidase
1775


P31350_C317
RRM2 Ribonucleoside-
1776



diphosphate reductase subunit



M2


Q04637_C1384
EIF4G1 Eukaryotic translation
1777



initiation factor 4 gamma 1


P63167_C56
DYNLL1 Dynein light chain 1,
1778



cytoplasmic


Q86WR0_C83
CCDC25 Coiled-coil domain-
1779



containing protein 25


P41227_C194
NAA10 N-alpha-
1780



acetyltransferase 10


Q9BY42_C262
C20orf43 UPF0549 protein
1781



C20orf43


Q9NVP2_C172
ASF1B Histone chaperone
1782



ASF1B


Q8IZ07_C540
ANKRD13A Ankyrin repeat
1783



domain-containing protein 13A


Q8IUI8_C154
CRLF3 Cytokine receptor-like
1784



factor 3


Q9H6S3_C543
EPS8L2 Epidermal growth
1785



factor receptor kinase substrate


Q06124_C573
PTPN11 Tyrosine-protein
1786



phosphatase non-receptor type



11


P62829_C125
RPL23 60S ribosomal protein
1787



L23


P55769_C93
NHP2L1 NHP2-like protein 1
1788


Q15233_C208
NONO Non-POU domain-
1789



containing octamer-binding



protein


Q13200_C459
PSMD2 26S proteasome non-
1790



ATPase regulatory subunit 2


Q9ULZ2_C269
STAP1 Signal-transducing
1791



adaptor protein 1


P78527_C3403
PRKDC DNA-dependent
1792



protein kinase catalytic subunit


Q9NZ63_C145
C9orf78 Uncharacterized
1793



protein C9orf78


P22234_C350
PAICS Multifunctional protein
1794



ADE2


Q9NX46_C132
ADPRHL2 Poly(ADP-ribose)
1795



glycohydrolase ARH3


Q6PJT7_C261
ZC3H14 Zinc finger CCCH
1796



domain-containing protein 14


P52789_C909
HK2 Hexokinase-2
1797


O00148_C86
DDX39A ATP-dependent
1798



RNA helicase DDX39A


P48643_C302
CCT5 T-complex protein 1
1799



subunit epsilon


Q9H6Z4_C203
RANBP3 Ran-binding protein
1800



3


P33991_C605
MCM4 DNA replication
1801



licensing factor MCM4


Q13330_C229
MTA1 Metastasis-associated
1802



protein MTA1


O95630_C264
STAMBP STAM-binding
1803



protein


P25786_C85
PSMA1 Proteasome subunit
1804



alpha type-1


P42704_C1277
LRPPRC Leucine-rich PPR
1805



motif-containing protein,



mitochondrial


Q9NR50_C106
EIF2B3 Translation initiation
1806



factor eIF-2B subunit gamma


Q9H299_C71
SH3BGRL3 SH3 domain-
1807



binding glutamic acid-rich-like



protein


Q32MZ4_C14
LRRFIP1 Leucine-rich repeat
1808



flightless-interacting protein


Q13619_C633
CUL4A Cullin-4A
1809


O75832_C107
PSMD10 26S proteasome non-
1810



ATPase regulatory subunit 10


O75874_C379
IDH1 Isocitrate dehydrogenase
1811


P04075_C178
ALDOA Fructose-
1812



bisphosphate aldolase A


P34897_C412
SHMT2 Serine
1813



hydroxymethyltransferase,



mitochondrial


Q9Y490_C1939
TLN1 Talin-1
1814


P26358_C896
DNMT1 DNA (cytosine-5)-
1815



methyltransferase 1


P52701_C88
MSH6 DNA mismatch repair
1816



protein Msh6


Q96G03_C573
PGM2 Phosphoglucomutase-2
1817


O00410_C1078
IPO5 Importin-5
1818


Q96FW1_C91
OTUB1 Ubiquitin thioesterase
1819



OTUB1


P02545_C591
LMNA Prelamin-A/C
1820


Q7Z5K2_C94
WAPAL Wings apart-like
1821



protein homolog


O75369_C991
FLNB Filamin-B
1822


Q969T9_C80
WBP2 WW domain-binding
1823



protein 2


Q9H773_C162
DCTPP1 dCTP
1824



pyrophosphatase 1


Q15424_C225
SAFB Scaffold attachment
1825



factor B1


P07900_C529
HSP90AA1 Heat shock protein
1826



HSP 90-alpha


P23396_C134
RPS3 40S ribosomal protein
1827



S3


Q8N9N8_C89
EIF1AD Probable RNA-
1828



binding protein EIF1AD


Q12888_C101
TP53BP1 Tumor suppressor
1829



p53-binding protein 1


P61970_C114
NUTF2 Nuclear transport
1830



factor 2


P18858_C895
LIG1 DNA ligase 1
1831


P13639_C693
EEF2 Elongation factor 2
1832


Q7L5D6_C160
GET4 Golgi to ER traffic
1833



protein 4 homolog


P63104_C25
YWHAZ 14-3-3 protein
1834



zeta/delta


Q14676_C26
MDC1 Mediator of DNA
1835



damage checkpoint protein 1


Q15021_C596
NCAPD2 Condensin complex
1836



subunit 1


O43815_C765
STRN Striatin
1837


Q13310_C339
PABPC4 Polyadenylate-
1838



binding protein 4


P62241_C71
RPS8 40S ribosomal protein
1839



S8


Q9Y263_C584
PLAA Phospholipase A-2-
1840



activating protein


O95801_C238
TTC4 Tetratricopeptide repeat
1841



protein 4


Q14192_C254
FHL2 Four and a half LIM
1842



domains protein 2


Q92841_C584
DDX17 Probable ATP-
1843



dependent RNA helicase



DDX17


P07814_C1148
EPRS Bifunctional
1844



glutamate/proline--tRNA



ligase


P61586_C159
RHOA Transforming protein
1845



RhoA


Q08J23_C221
NSUN2 tRNA (cytosine(34)-
1846



C(5))-methyltransferase


Q9UER7_C699
DAXX Death domain-
1847



associated protein 6


P05161_C78
ISG15 Ubiquitin-like protein
1848



ISG15


P07741_C140
APRT Adenine
1849



phosphoribosyltransferase


P08238_C412
HSP90AB1 Heat shock protein
1850



HSP 90-beta


P53597_C60
SUCLG1 Succinyl-CoA ligase
1851


Q9UPY8_C182
MAPRE3 Microtubule-
1852



associated protein RP/EB



family member


P61247_C139
RPS3A 40S ribosomal protein
1853



S3a


Q9Y2L1_C799
DIS3 Exosome complex
1854



exonuclease RRP44


P23921_C352
RRM1 Ribonucleoside-
1855



diphosphate reductase large



subunit


P07954_C333
FH Fumarate hydratase,
1856



mitochondrial


O00429_C361
DNM1L Dynamin-1-like
1857



protein


P00491_C31
PNP Purine nucleoside
1858



phosphorylase


P61927_C37
RPL37 60S ribosomal protein
1859



L37


Q16543_C336
CDC37 Hsp90 co-chaperone
1860



Cdc37


P49753_C401
ACOT2 Acyl-coenzyme A
1861



thioesterase 2, mitochondrial


Q9BSH4_C256
TACO1 Translational activator
1862



of cytochrome c oxidase 1


P43686_C379
PSMC4 26S protease
1863



regulatory subunit 6B


O75717_C285
WDHD1 WD repeat and
1864



HMG-box DNA-binding



protein 1


P36776_C520
LONP1 Lon protease homolog,
1865



mitochondrial


P36776_C637
LONP1 Lon protease homolog,
1866



mitochondrial


Q16666_C637
IFI16 Gamma-interferon-
1867



inducible protein 16


Q92619_C1020
HMHA1 Minor
1868



histocompatibility protein HA-



1


Q9P289_C77
MST4 Serine/threonine-protein
1869



kinase MST4


H3BVE0_C63
Uncharacterized protein
1870


P60891_C91
PRPS1 Ribose-phosphate
1871



pyrophosphokinase 1


Q01813_C343
PFKP 6-phosphofructokinase
1872



type C


P04632_C144
CAPNS1 Calpain small
1873



subunit 1


Q7Z6Z7_C790
HUWE1 E3 ubiquitin-protein
1874



ligase HUWE1


O14933_C102
UBE2L6 Ubiquitin/ISG15-
1875



conjugating enzyme E2 L6


Q8WUA4_C212
GTF3C2 General transcription
1876



factor 3C polypeptide 2


Q9UJU6_C127
DBNL Drebrin-like protein
1877


P21333_C2199
FLNA Filamin-A
1878


P45880_C47
VDAC2 Voltage-dependent
1879



anion-selective channel protein


P23396_C119
RPS3 40S ribosomal protein
1880



S3


P13489_C30
RNH1 Ribonuclease inhibitor
1881


P17676_C248
CEBPB CCAAT/enhancer-
1882



binding protein beta


Q92974_C478
ARHGEF2 Rho guanine
1883



nucleotide exchange factor 2


O75995_C351
SASH3 SAM and SH3
1884



domain-containing protein 3


P61978_C184
HNRNPK Heterogeneous
1885



nuclear ribonucleoprotein K


Q15149_C3295
PLEC Plectin
1886


P11142_C574
HSPA8 Heat shock cognate 71
1887



kDa protein


P21964_C223
COMT Catechol O-
1888



methyltransferase


Q96TA1_C466
FAM129B Niban-like protein
1889



1


Q9NVG8_C145
TBC1D13 TBC1 domain
1890



family member 13


Q96EV2_C726
RBM33 RNA-binding protein
1891



33


P00505_C295
GOT2 Aspartate
1892



aminotransferase,



mitochondrial


Q92945_C436
KHSRP Far upstream element-
1893



binding protein 2


P46734_C227
MAP2K3 Dual specificity
1894



mitogen-activated protein



kinase


P68104_C370
EEF1A1 Elongation factor 1-
1895



alpha 1


Q14204_C4216
DYNC1H1 Cytoplasmic
1896



dynein 1 heavy chain 1


P55060_C939
CSE1L Exportin-2
1897


Q8WYJ6_C293
SEPT1 Septin-1
1898


Q04760_C61
GLO1 Lactoylglutathione
1899



lyase


P54105_C73
CLNS1A Methylosome
1900



subunit pICln


Q99439_C274
CNN2 Calponin-2
1901


Q15054_C137
POLD3 DNA polymerase delta
1902



subunit 3


Q14232_C169
EIF2B1 Translation initiation
1903



factor eIF-2B subunit alpha


Q8TB45_C284
DEPTOR DEP domain-
1904



containing mTOR-interacting



protein


P18031_C92
PTPN1 Tyrosine-protein
1905



phosphatase non-receptor type



1


O60343_C74
TBC1D4 TBC1 domain family
1906



member 4


Q9NQW6_C353
ANLN Actin-binding protein
1907



anillin


Q86U90_C99
YRDC YrdC domain-
1908



containing protein,



mitochondrial


Q9Y3D2_C45
MSRB2 Methionine-R-
1909



sulfoxide reductase B2,



mitochondrial


Q9P258_C144
RCC2 Protein RCC2
1910


P56192_C441
MARS Methionine--tRNA
1911



ligase, cytoplasmic


P31751_C311
AKT2 RAC-beta
1912



serine/threonine-protein kinase


O00410_C915
IPO5 Importin-5
1913


Q53ET0_C515
CRTC2 CREB-regulated
1914



transcription coactivator 2


P29401_C417
TKT Transketolase
1915


Q9UPN9_C461
TRIM33 E3 ubiquitin-protein
1916



ligase TRIM33


P16152_C227
CBR1 Carbonyl reductase
1917


P49419_C478
ALDH7A1 Alpha-aminoadipic
1918



semialdehyde dehydrogenase


Q9BX40_C310
LSM14B Protein LSM14
1919



homolog B


Q93009_C315
USP7 Ubiquitin carboxyl-
1920



terminal hydrolase 7


Q9P0L0_C60
VAPA Vesicle-associated
1921



membrane protein-associated



protein A


Q9Y617_C291
PSAT1 Phosphoserine
1922



aminotransferase


Q5U5X0_C97
LYRM7 LYR motif-containing
1923



protein 7


O75390_C101
CS Citrate synthase,
1924



mitochondrial


P53602_C386
MVD Diphosphomevalonate
1925



decarboxylase


P60953_C157
CDC42 Cell division control
1926



protein 42 homolog


P09936_C47
UCHL1 Ubiquitin carboxyl-
1927



terminal hydrolase isozyme L1


P21333_C1018
FLNA Filamin-A
1928


O00267_C740
SUPT5H Transcription
1929



elongation factor SPT5


P42166_C518
TMPO Lamina-associated
1930



polypeptide 2, isoform alpha


P41091_C105
EIF2S3 Eukaryotic translation
1931



initiation factor 2 subunit


Q92973_C297
TNPO1 Transportin-1
1932


Q15149_C3336
PLEC Plectin
1933


P22314_C278
UBA1 Ubiquitin-like modifier-
1934



activating enzyme 1


P38117_C42
ETFB Electron transfer
1935



flavoprotein subunit beta


P62316_C46
SNRPD2 Small nuclear
1936



ribonucleoprotein Sm D2


P48735_C154
IDH2 Isocitrate dehydrogenase
1937


O00151_C45
PDLIM1 PDZ and LIM
1938



domain protein 1


Q8IUD2_C258
ERC1 ELKS/Rab6-
1939



interacting/CAST family



member 1


P55210_C186
CASP7 Caspase-7
1940


Q9BY77_C338
POLDIP3 Polymerase delta-
1941



interacting protein 3


Q13501_C131
SQSTM1 Sequestosome-1
1942


Q96ST2_C749
IWS1 Protein IWS1 homolog
1943


P41250_C180
GARS Glycine--tRNA ligase
1944


Q96EB6_C67
SIRT1 NAD-dependent protein
1945



deacetylase sirtuin-1


P23921_C492
RRM1 Ribonucleoside-
1946



diphosphate reductase large



subunit


Q53H96_C235
PYCRL Pyrroline-5-
1947



carboxylate reductase 3


B9A064_C213
IGLL5 Immunoglobulin
1948



lambda-like polypeptide 5


P49588_C947
AARS Alanine--tRNA ligase,
1949



cytoplasmic


P25398_C56
RPS12 40S ribosomal protein
1950



S12


P28066_C165
PSMA5 Proteasome subunit
1951



alpha type-5


P46937_C343
YAP1 Yorkie homolog
1952


Q16836_C211
HADH Hydroxyacyl-
1953



coenzyme A dehydrogenase,



mitochondrial


P30626_C57
SRI Sorcin
1954


P49023_C108
PXN Paxillin
1955


P35270_C159
SPR Sepiapterin reductase
1956


P02545_C588
LMNA Prelamin-A/C
1957


P08621_C39
SNRNP70 U1 small nuclear
1958



ribonucleoprotein 70 kDa


Q14566_C91
MCM6 DNA replication
1959



licensing factor MCM6


Q14103_C226
HNRNPD Heterogeneous
1960



nuclear ribonucleoprotein D0


P26641_C194
EEF1G Elongation factor 1-
1961



gamma


Q9UK41_C128
VPS28 Vacuolar protein
1962



sorting-associated protein 28



homolog


Q9BQ52_C441
ELAC2 Zinc
1963



phosphodiesterase ELAC



protein 2


P04632_C232
CAPNS1 Calpain small
1964



subunit 1


P09936_C90
UCHL1 Ubiquitin carboxyl-
1965



terminal hydrolase isozyme L1


P21333_C1912
FLNA Filamin-A
1966


P30566_C340
ADSL Adenylosuccinate lyase
1967


O95983_C215
MBD3 Methyl-CpG-binding
1968



domain protein 3


P40925_C251
MDH1 Malate dehydrogenase,
1969



cytoplasmic


P78417_C90
GSTO1 Glutathione S-
1970



transferase omega-1


P17655_C82
CAPN2 Calpain-2 catalytic
1971



subunit


O75688_C172
PPM1B Protein phosphatase
1972



1B


Q09666_C2806
AHNAK Neuroblast
1973



differentiation-associated



protein AHNA


P62140_C126
PPP1CB Serine/threonine-
1974



protein phosphatase PP1-beta



cata


P54687_C8
BCAT1 Branched-chain-
1975



amino-acid aminotransferase,



cytosol


O60934_C487
NBN Nibrin
1976


Q9NZT2_C443
OGFR Opioid growth factor
1977



receptor


P52789_C834
HK2 Hexokinase-2
1978


P35579_C671
MYH9 Myosin-9
1979


Q9HAV7_C108
GRPEL1 GrpE protein
1980



homolog 1, mitochondrial


O43175_C18
PHGDH D-3-
1981



phosphoglycerate



dehydrogenase


O43175_C295
PHGDH D-3-
1982



phosphoglycerate



dehydrogenase


P12004_C162
PCNA Proliferating cell
1983



nuclear antigen


O75531_C85
BANF1 Barrier-to-
1984



autointegration factor


P46940_C494
IQGAP1 Ras GTPase-
1985



activating-like protein



IQGAP1


P11586_C195
MTHFD1 C-1-tetrahydrofolate
1986



synthase, cytoplasmic


Q7Z5L9_C65
IRF2BP2 Interferon regulatory
1987



factor 2-binding protein 2


Q9Y5K6_C595
CD2AP CD2-associated
1988



protein


Q9Y5L0_C511
TNPO3 Transportin-3
1989


Q9NZN4_C138
EHD2 EH domain-containing
1990



protein 2


Q13813_C2233
SPTAN1 Spectrin alpha chain,
1991



non-erythrocytic 1


P62910_C91
RPL32 60S ribosomal protein
1992



L32


O76003_C229
GLRX3 Glutaredoxin-3
1993


P08559_C181
PDHA1 Pyruvate
1994



dehydrogenase E1 component



subunit alpha,


P42126_C173
ECI1 Enoyl-CoA delta
1995



isomerase 1, mitochondrial


P84103_C6
SRSF3 Serine/arginine-rich
1996



splicing factor 3


Q14566_C540
MCM6 DNA replication
1997



licensing factor MCM6


P21980_C290
TGM2 Protein-glutamine
1998



gamma-glutamyltransferase 2


O75391_C191
SPAG7 Sperm-associated
1999



antigen 7


P31943_C22
HNRNPH1 Heterogeneous
2000



nuclear ribonucleoprotein H


P31943_C290
HNRNPH1 Heterogeneous
2001



nuclear ribonucleoprotein H


O95347_C132
SMC2 Structural maintenance
2002



of chromosomes protein 2


O95983_C172
MBD3 Methyl-CpG-binding
2003



domain protein 3


P49321_C788
NASP Nuclear autoantigenic
2004



sperm protein


P13489_C96
RNH1 Ribonuclease inhibitor
2005


Q86V48_C969
LUZP1 Leucine zipper protein
2006



1


Q14240_C135
EIF4A2 Eukaryotic initiation
2007



factor 4A-II


P22307_C71
SCP2 Non-specific lipid-
2008



transfer protein


Q9Y3B4_C83
SF3B14 Pre-mRNA branch
2009



site protein p14


Q8WUM4_C512
PDCD6IP Programmed cell
2010



death 6-interacting protein


Q8IXH7_C293
TH1L Negative elongation
2011



factor C/D


Q15003_C296
NCAPH Condensin complex
2012



subunit 2


Q9C0B1_C171
FTO Alpha-ketoglutarate-
2013



dependent dioxygenase FTO


Q8WXI9_C308
GATAD2B Transcriptional
2014



repressor p66-beta


P07814_C856
EPRS Bifunctional
2015



glutamate/proline--tRNA



ligase


P22102_C134
GART Trifunctional purine
2016



biosynthetic protein adenosin


Q13425_C374
SNTB2 Beta-2-syntrophin
2017


Q04760_C139
GLO1 Lactoylglutathione
2018



lyase


P25789_C163
PSMA4 Proteasome subunit
2019



alpha type-4


P07355_C262
ANXA2 Annexin A2
2020


P53597_C172
SUCLG1 Succinyl-CoA ligase
2021


P26368_C429
U2AF2 Splicing factor U2AF
2022



65 kDa subunit


Q05086_C83
UBE3A Ubiquitin-protein
2023



ligase E3A


O00170_C208
AIP AH receptor-interacting
2024



protein


P31323_C116
PRKAR2B cAMP-dependent
2025



protein kinase type II-beta



regulat


Q8WW33_C51
GTSF1 Gametocyte-specific
2026



factor 1


Q9Y5Y2_C196
NUBP2 Cytosolic Fe—S cluster
2027



assembly factor NUBP2


O95456_C169
PSMG1 Proteasome assembly
2028



chaperone 1


P13796_C618
LCP1 Plastin-2
2029


P23921_C779
RRM1 Ribonucleoside-
2030



diphosphate reductase large



subunit


P31689_C149
DNAJA1 DnaJ homolog
2031



subfamily A member 1


Q9Y490_C1045
TLN1 Talin-1
2032


Q9UGI8_C196
TES Testin
2033


P54136_C369
RARS Arginine--tRNA ligase,
2034



cytoplasmic


P47756_C62
CAPZB F-actin-capping
2035



protein subunit beta


P47897_C657
QARS Glutamine--tRNA
2036



ligase


P56192_C12
MARS Methionine--tRNA
2037



ligase, cytoplasmic


Q9Y570_C312
PPME1 Protein phosphatase
2038



methylesterase 1


Q7L4I2_C382
RSRC2 Arginine/serine-rich
2039



coiled-coil protein 2


Q13496_C53
MTM1 Myotubularin
2040


O15460_C510
P4HA2 Prolyl 4-hydroxylase
2041



subunit alpha-2


P00558_C99
PGK1 Phosphoglycerate
2042



kinase 1


P05412_C99
JUN Transcription factor AP-1
2043


Q9H3R5_C35
CENPH Centromere protein H
2044


Q02543_C16
RPL18A 60S ribosomal
2045



protein L18a


Q06587_C69
RING1 E3 ubiquitin-protein
2046



ligase RING1


Q15365_C163
PCBP1 Poly(rC)-binding
2047



protein 1


O75369_C660
FLNB Filamin-B
2048


O75369_C2537
FLNB Filamin-B
2049


Q5RKV6_C117
EXOSC6 Exosome complex
2050



component MTR3


O15067_C606
PFAS
2051



Phosphoribosylformylglycinamidine



synthase


Q9HB19_C191
PLEKHA2 Pleckstrin
2052



homology domain-containing



family A member 2


Q8WVV9_C84
HNRPLL Heterogeneous
2053



nuclear ribonucleoprotein L-



like


O95400_C234
CD2BP2 CD2 antigen
2054



cytoplasmic tail-binding



protein 2


O94804_C947
STK10 Serine/threonine-
2055



protein kinase 10


Q5TBB1_C56
RNASEH2B Ribonuclease H2
2056



subunit B


Q96GW9_C425
MARS2 Methionine--tRNA
2057



ligase, mitochondrial


P82912_C112
MRPS11 28S ribosomal
2058



protein S11, mitochondrial


Q16643_C613
DBN1 Drebrin
2059


Q9UPQ0_C577
LIMCH1 LIM and calponin
2060



homology domains-containing



prote


P21333_C1453
FLNA Filamin-A
2061


Q9UGV2_C166
NDRG3 Protein NDRG3
2062


P40926_C89
MDH2 Malate dehydrogenase,
2063



mitochondrial


P40926_C93
MDH2 Malate dehydrogenase,
2064



mitochondrial


Q14839_C1594
CHD4 Chromodomain-
2065



helicase-DNA-binding protein



4


O95273_C300
CCNDBP1 Cyclin-D1-binding
2066



protein 1


A6NE09_C163
RPSAP58 Protein RPSAP58
2067


P62942_C23
FKBP1A Peptidyl-prolyl cis-
2068



trans isomerase FKBP1A


Q04446_C221
GBE1 1,4-alpha-glucan-
2069



branching enzyme


P16219_C289
ACADS Short-chain specific
2070



acyl-CoA dehydrogenase,



mitochondrial


Q9Y3C6_C133
PPIL1 Peptidyl-prolyl cis-trans
2071



isomerase-like 1


P61970_C80
NUTF2 Nuclear transport
2072



factor 2


O14776_C535
TCERG1 Transcription
2073



elongation regulator 1


Q9BRP1_C278
PDCD2L Programmed cell
2074



death protein 2-like


P13639_C567
EEF2 Elongation factor 2
2075


Q8WUX2_C113
CHAC2 Cation transport
2076



regulator-like protein 2


Q9H8W4_C219
PLEKHF2 Pleckstrin
2077



homology domain-containing



family F member 2


Q15021_C286
NCAPD2 Condensin complex
2078



subunit 1


O95394_C93
PGM3
2079



Phosphoacetylglucosamine



mutase


Q9NP61_C312
ARFGAP3 ADP-ribosylation
2080



factor GTPase-activating



protein


Q86TG7_C119
PEG10 Retrotransposon-
2081



derived protein PEG10


Q7L0Y3_C78
TRMT10C Mitochondrial
2082



ribonuclease P protein 1


P35579_C694
MYH9 Myosin-9
2083


Q7Z7A4_C570
PXK PX domain-containing
2084



protein kinase-like protein


P05091_C386
ALDH2 Aldehyde
2085



dehydrogenase, mitochondrial


O15231_C615
ZNF185 Zinc finger protein
2086



185


Q9P2J5_C573
LARS Leucine--tRNA ligase,
2087



cytoplasmic


P41250_C525
GARS Glycine--tRNA ligase
2088


Q9NR33_C84
POLE4 DNA polymerase
2089



epsilon subunit 4


Q9NQW6_C210
ANLN Actin-binding protein
2090



anillin


Q9NQW6_C1117
ANLN Actin-binding protein
2091



anillin


Q9HCC0_C267
MCCC2 Methylcrotonoyl-CoA
2092



carboxylase beta chain, mitoch


P55884_C420
EIF3B Eukaryotic translation
2093



initiation factor 3 subunit


P20290_C22
BTF3 Transcription factor
2094



BTF3


P49368_C398
CCT3 T-complex protein 1
2095



subunit gamma


O75600_C106
GCAT 2-amino-3-ketobutyrate
2096



coenzyme A ligase,



mitochondrial


Q6PKG0_C864
LARP1 La-related protein 1
2097


Q5H9R7_C467
PPP6R3 Serine/threonine-
2098



protein phosphatase 6



regulatory


Q9H4A4_C311
RNPEP Aminopeptidase B
2099


Q9BUF5_C12
TUBB6 Tubulin beta-6 chain
2100


P52272_C676
HNRNPM Heterogeneous
2101



nuclear ribonucleoprotein M


Q8TB03_C300
CXorf38 Uncharacterized
2102



protein CXorf38


Q9H7D7_C656
WDR26 WD repeat-containing
2103



protein 26


P50395_C317
GDI2 Rab GDP dissociation
2104



inhibitor beta


P25205_C263
MCM3 DNA replication
2105



licensing factor MCM3


Q8TD19_C878
NEK9 Serine/threonine-protein
2106



kinase Nek9


P31947_C96
SFN 14-3-3 protein sigma
2107


P49321_C568
NASP Nuclear autoantigenic
2108



sperm protein


Q7L2J0_C54
MEPCE 7SK snRNA
2109



methylphosphate capping



enzyme


Q96BN8_C347
FAM105B Protein FAM105B
2110


Q12888_C1159
TP53BP1 Tumor suppressor
2111



p53-binding protein 1


P29034_C22
S100A2 Protein S100-A2
2112


P61978_C205
HNRNPK Heterogeneous
2113



nuclear ribonucleoprotein K


P78527_C3837
PRKDC DNA-dependent
2114



protein kinase catalytic subunit


Q7LG56_C279
RRM2B Ribonucleoside-
2115



diphosphate reductase subunit



M2 B


P12814_C180
ACTN1 Alpha-actinin-1
2116


Q9ULV4_C343
CORO1C Coronin-1C
2117


P22234_C185
PAICS Multifunctional protein
2118



ADE2


P22234_C288
PAICS Multifunctional protein
2119



ADE2


P30837_C386
ALDH1B1 Aldehyde
2120



dehydrogenase X,



mitochondrial


P25098_C120
ADRBK1 Beta-adrenergic
2121



receptor kinase 1


P35998_C180
PSMC2 26S protease
2122



regulatory subunit 7


P08243_C255
ASNS Asparagine synthetase
2123


O95819_C202
MAP4K4 Mitogen-activated
2124



protein kinase kinase kinase



kin


Q13557_C273
CAMK2D
2125



Calcium/calmodulin-dependent



protein kinase type I


P50213_C127
IDH3A Isocitrate
2126



dehydrogenase


O95336_C237
PGLS 6-
2127



phosphogluconolactonase


Q13155_C143
AIMP2 Aminoacyl tRNA
2128



synthase complex-interacting



multifunctional protein 2


Q14204_C3940
DYNC1H1 Cytoplasmic
2129



dynein 1 heavy chain 1


P30154_C306
PPP2R1B Serine/threonine-
2130



protein phosphatase 2A 65 kDa



regulatory subunit A beta



isoform


P61758_C113
VBP1 Prefoldin subunit 3
2131


P48739_C13
PITPNB Phosphatidylinositol
2132



transfer protein beta isoform


P08134_C159
RHOC Rho-related GTP-
2133



binding protein RhoC


P15121_C81
AKR1B1 Aldose reductase
2134


P86790_C358
CCZ1B Vacuolar fusion
2135



protein CCZ1 homolog B


P42704_C863
LRPPRC Leucine-rich PPR
2136



motif-containing protein,



mitochondrial


P33316_C166
DUT Deoxyuridine 5-
2137



triphosphate



nucleotidohydrolase,


Q92597_C289
NDRG1 Protein NDRG1
2138


P35236_C62
PTPN7 Tyrosine-protein
2139



phosphatase non-receptor type



7


P17987_C296
TCP1 T-complex protein 1
2140



subunit alpha


Q6PI48_C590
DARS2 Aspartate--tRNA
2141



ligase, mitochondrial


P63244_C249
GNB2L1 Guanine nucleotide-
2142



binding protein subunit beta-2-



like 1


Q12874_C437
SF3A3 Splicing factor 3A
2143



subunit 3


Q9Y6W5_C27
WASF2 Wiskott-Aldrich
2144



syndrome protein family



member 2


P04075_C290
ALDOA Fructose-
2145



bisphosphate aldolase A


Q8WW33_C76
GTSF1 Gametocyte-specific
2146



factor 1


P57081_C137
WDR4 tRNA (guanine-N(7)-)-
2147



methyltransferase subunit



WDR


O60343_C1277
TBC1D4 TBC1 domain family
2148



member 4


P30084_C111
ECHS1 Enoyl-CoA hydratase,
2149



mitochondrial


P12268_C173
IMPDH2 Inosine-5-
2150



monophosphate dehydrogenase



2


O43290_C674
SART1 U4/U6.U5 tri-snRNP-
2151



associated protein 1


Q9P258_C280
RCC2 Protein RCC2
2152


P15153_C6
RAC2 Ras-related C3
2153



botulinum toxin substrate 2


O60361_C94
NME2P1 Putative nucleoside
2154



diphosphate kinase


O75600_C219
GCAT 2-amino-3-ketobutyrate
2155



coenzyme A ligase,



mitochondrial


O60568_C494
PLOD3 Procollagen-lysine,2-
2156



oxoglutarate 5-dioxygenase 3


Q9H0R6_C512
QRSL1 Glutamyl-tRNA(Gln)
2157



amidotransferase subunit A,



mitochondrial


Q7RTV0_C11
PHF5A PHD finger-like
2158



domain-containing protein 5A


Q96I99_C255
SUCLG2 Succinyl-CoA ligase
2159


A0AVT1_C770
UBA6 Ubiquitin-like modifier-
2160



activating enzyme 6


P08047_C755
SP1 Transcription factor Sp1
2161


P26641_C166
EEF1G Elongation factor 1-
2162



gamma


Q16270_C131
IGFBP7 Insulin-like growth
2163



factor-binding protein 7


Q9BQ52_C51
ELAC2 Zinc
2164



phosphodiesterase ELAC



protein 2


Q6YN16_C11
HSDL2 Hydroxysteroid
2165



dehydrogenase-like protein 2


Q9BQP7_C79
C20orf72 Uncharacterized
2166



protein C20orf72


Q7Z6Z7_C2865
HUWE1 E3 ubiquitin-protein
2167



ligase HUWE1


Q7Z6Z7_C3259
HUWE1 E3 ubiquitin-protein
2168



ligase HUWE1


Q7Z6Z7_C3658
HUWE1 E3 ubiquitin-protein
2169



ligase HUWE1


Q14914_C239
PTGR1 Prostaglandin
2170



reductase 1


O00268_C1022
TAF4 Transcription initiation
2171



factor TFIID subunit 4


O95340_C155
PAPSS2 Bifunctional 3-
2172



phosphoadenosine 5-



phosphosulfate


O95295_C66
SNAPIN SNARE-associated
2173



protein Snapin


P43490_C287
NAMPT Nicotinamide
2174



phosphoribosyltransferase


P49327_C135
FASN Fatty acid synthase
2175


Q9Y383_C59
LUC7L2 Putative RNA-
2176



binding protein Luc7-like 2


Q9NS86_C49
LANCL2 LanC-like protein 2
2177


Q15149_C317
PLEC Plectin
2178


O60825_C430
PFKFB2 6-phosphofructo-2-
2179



kinase/fructose-2,6-



bisphosphatase 2


Q5JS54_C55
PSMG4 Proteasome assembly
2180



chaperone 4


P52566_C76
ARHGDIB Rho GDP-
2181



dissociation inhibitor 2


P07203_C156
GPX1 Glutathione peroxidase
2182



1


Q9UL25_C29
RAB21 Ras-related protein
2183



Rab-21


P49841_C14
GSK3B Glycogen synthase
2184



kinase-3 beta


P17655_C39
CAPN2 Calpain-2 catalytic
2185



subunit


Q14315_C2679
FLNC Filamin-C
2186


P32969_C74
RPL9P9 60S ribosomal protein
2187



L9


Q96JH7_C1178
VCPIP1 Deubiquitinating
2188



protein VCIP135


Q9NP61_C241
ARFGAP3 ADP-ribosylation
2189



factor GTPase-activating



protein


Q9Y265_C141
RUVBL1 RuvB-like 1
2190


P52789_C158
HK2 Hexokinase-2
2191


P35579_C172
MYH9 Myosin-9
2192


P12955_C482
PEPD Xaa-Pro dipeptidase
2193


Q86UX7_C235
FERMT3 Fermitin family
2194



homolog 3


Q15003_C239
NCAPH Condensin complex
2195



subunit 2


P07814_C1377
EPRS Bifunctional
2196



glutamate/proline--tRNA



ligase


P11586_C143
MTHFD1 C-1-tetrahydrofolate
2197



synthase, cytoplasmic


P62312_C36
LSM6 U6 snRNA-associated
2198



Sm-like protein LSm6


P55209_C132
NAP1L1 Nucleosome
2199



assembly protein 1-like 1


O75815_C699
BCAR3 Breast cancer anti-
2200



estrogen resistance protein 3


P24534_C191
EEF1B2 Elongation factor 1-
2201



beta


P15121_C200
AKR1B1 Aldose reductase
2202


Q9GZU8_C187
FAM192A Protein FAM192A
2203


P25789_C34
PSMA4 Proteasome subunit
2204



alpha type-4


P25789_C74
PSMA4 Proteasome subunit
2205



alpha type-4


P07355_C133
ANXA2 Annexin A2
2206


Q15393_C410
SF3B3 Splicing factor 3B
2207



subunit 3


P63244_C240
GNB2L1 Guanine nucleotide-
2208



binding protein subunit beta-2-



like 1


P61247_C111
RPS3A 40S ribosomal protein
2209



S3a


P53582_C40
METAP1 Methionine
2210



aminopeptidase 1


P23921_C790
RRM1 Ribonucleoside-
2211



diphosphate reductase large



subunit R


Q9BT78_C378
COPS4 COP9 signalosome
2212



complex subunit 4


Q7KZ85_C336
SUPT6H Transcription
2213



elongation factor SPT6


P23381_C274
WARS Tryptophan--tRNA
2214



ligase, cytoplasmic


P36551_C239
CPOX Coproporphyrinogen-
2215



III oxidase, mitochondrial


Q7KZF4_C31
SND1 Staphylococcal nuclease
2216



domain-containing protein


Q14139_C1002
UBE4A Ubiquitin conjugation
2217



factor E4 A


Q8NCF5_C232
NFATC2IP NFATC2-
2218



interacting protein


O75934_C106
BCAS2 Pre-mRNA-splicing
2219



factor SPF27


Q96IF1_C158
AJUBA LIM domain-
2220



containing protein ajuba


Q9NZL4_C22
HSPBP1 Hsp70-binding
2221



protein 1


Q9NZL9_C58
MAT2B Methionine
2222



adenosyltransferase 2 subunit



beta


Q5TDH0_C361
DDI2 Protein DDI1 homolog 2
2223


Q13126_C131
MTAP S-methyl-5-
2224



thioadenosine phosphorylase


O75369_C706
FLNB Filamin-B
2225


P21980_C269
TGM2 Protein-glutamine
2226



gamma-glutamyltransferase 2


Q16270_C113
IGFBP7 Insulin-like growth
2227



factor-binding protein 7


H7BZ11_C88
Uncharacterized protein
2228


Q96FZ2_C131
C3orf37 UPF0361 protein
2229



C3orf37


Q6YN16_C71
HSDL2 Hydroxysteroid
2230



dehydrogenase-like protein 2


Q9UBL3_C581
ASH2L Set1/Ash2 histone
2231



methyltransferase complex



subunit


Q15370_C60
TCEB2 Transcription
2232



elongation factor B



polypeptide 2


O43252_C360
PAPSS1 Bifunctional 3-
2233



phosphoadenosine 5-



phosphosulfete


P62633_C171
CNBP Cellular nucleic acid-
2234



binding protein


P63151_C398
PPP2R2A Serine/threonine-
2235



protein phosphatase 2A 55 kDa



regulatory subunit B alpha



isoform


Q16881_C209
TXNRD1 Thioredoxin
2236



reductase 1, cytoplasmic


O95294_C761
RASAL1 RasGAP-activating-
2237



like protein 1


Q9UQ35_C872
SRRM2 Serine/arginine
2238



repetitive matrix protein 2


P78371_C535
CCT2 T-complex protein 1
2239



subunit beta


P54577_C250
YARS Tyrosine--tRNA ligase,
2240



cytoplasmic


Q8TD30_C477
GPT2 Alanine
2241



aminotransferase 2


Q15149_C3299
PLEC Plectin
2242


O14744_C278
PRMT5 Protein arginine N-
2243



methyltransferase 5


Q7L1Q6_C96
BZW1 Basic leucine zipper
2244



and W2 domain-containing



prot


P04181_C150
OAT Ornithine
2245



aminotransferase,



mitochondrial


P04181_C330
OAT Ornithine
2246



aminotransferase,



mitochondrial


Q9NVT9_C69
ARMC1 Armadillo repeat-
2247



containing protein 1


O60888_C96
CUTA Protein CutA
2248


Q6P2E9_C976
EDC4 Enhancer of mRNA-
2249



decapping protein 4


P20810_C408
CAST Calpastatin
2250


Q5T6F2_C208
UBAP2 Ubiquitin-associated
2251



protein 2


Q9BQ61_C165
C19orf43 Uncharacterized
2252



protein C19orf43


P54687_C12
BCAT1 Branched-chain-
2253



amino-acid aminotransferase,



cytosolic


P54687_C335
BCAT1 Branched-chain-
2254



amino-acid aminotransferase,



cytosolic


Q96I15_C22
SCLY Selenocysteine lyase
2255


P45974_C335
USP5 Ubiquitin carboxyl-
2256



terminal hydrolase 5


O14497_C336
ARID1A AT-rich interactive
2257



domain-containing protein 1A


O43776_C438
NARS Asparagine--tRNA
2258



ligase, cytoplasmic


P12955_C467
PEPD Xaa-Pro dipeptidase
2259


Q9Y678_C97
COPG1 Coatomer subunit
2260



gamma-1


Q9Y678_C169
COPG1 Coatomer subunit
2261



gamma-1


P55786_C339
NPEPPS Puromycin-sensitive
2262



aminopeptidase


Q9Y520_C223
PRRC2C Protein PRRC2C
2263


P52306_C29
RAP1GDS1 Rap1 GTPase-
2264



GDP dissociation stimulator 1


Q6GMV2_C194
SMYD5 SET and MYND
2265



domain-containing protein 5


Q16763_C95
UBE2S Ubiquitin-conjugating
2266



enzyme E2 S


Q7L014_C590
DDX46 Probable ATP-
2267



dependent RNA helicase



DDX46


Q8NFX7_C144
STXBP6 Syntaxin-binding
2268



protein 6


P56537_C11
EIF6 Eukaryotic translation
2269



initiation factor 6


Q9NRL3_C17
STRN4 Striatin-4
2270


P41252_C185
IARS Isoleucine--tRNA ligase,
2271



cytoplasmic


O60343_C45
TBC1D4 TBC1 domain family
2272



member 4


P30086_C133
PEBP1
2273



Phosphatidylethanolamine-



binding protein 1


Q9NQW7_C308
XPNPEP1 Xaa-Pro
2274



aminopeptidase 1


O00299_C89
CLIC1 Chloride intracellular
2275



channel protein 1


Q9Y4B6_C784
VPRBP Protein VPRBP
2276


Q66PJ3_C349
ARL6IP4 ADP-ribosylation
2277



factor-like protein 6-interacting


P00367_C327
GLUD1 Glutamate
2278



dehydrogenase 1,



mitochondrial


Q14C86_C568
GAPVD1 GTPase-activating
2279



protein and VPS9 domain-



containing protein 1


P09382_C89
LGALS1 Galectin-1
2280


O00244_C41
ATOX1 Copper transport
2281



protein ATOX1


P16885_C624
PLCG2 1-phosphatidylinositol
2282



4,5-bisphosphate



phosphodiesterase


Q92835_C138
INPP5D Phosphatidylinositol
2283



3,4,5-trisphosphate 5-



phosphatase 1


J3QR44_C430
CDK11B Cyclin-dependent
2284



kinase 11B


Q9P289_C352
MST4 Serine/threonine-protein
2285



kinase MST4


Q92688_C27
ANP32B Acidic leucine-rich
2286



nuclear phosphoprotein 32



family member B


Q96GX9_C97
APIP Probable
2287



methylthioribulose-1-



phosphate dehydratase


Q15004_C54
KIAA0101 PCNA-associated
2288



factor


O75083_C325
WDR1 WD repeat-containing
2289



protein 1


O43252_C207
PAPSS1 Bifunctional 3-
2290



phosphoadenosine 5-



phosphosulfate


P62633_C161
CNBP Cellular nucleic acid-
2291



binding protein


Q7Z6Z7_C2832
HUWE1 E3 ubiquitin-protein
2292



ligase HUWE1


Q8NCW5_C91
APOA1BP NAD(P)H-hydrate
2293



epimerase


P31949_C13
S100A11 Protein S100-A11
2294


P07900_C572
HSP90AA1 Heat shock protein
2295



HSP 90-alpha


Q86UA6_C122
RPAIN RPA-interacting
2296



protein


Q8N6M0_C172
OTUD6B OTU domain-
2297



containing protein 6B


Q13153_C411
PAK1 Serine/threonine-protein
2298



kinase PAK 1


O60232_C53
SSSCA1 Sjoegren
2299



syndrome/scleroderma



autoantigen 1


Q9NQY0_C72
BIN3 Bridging integrator 3
2300


O60942_C419
RNGTT mRNA-capping
2301



enzyme


P13804_C155
ETFA Electron transfer
2302



flavoprotein subunit alpha,



mitochondrial


Q96QR8_C17
PURB Transcriptional
2303



activator protein Pur-beta


O60711_C199
LPXN Leupaxin
2304


Q00013_C242
MPP1 55 kDa erythrocyte
2305



membrane protein


P52597_C290
HNRNPF Heterogeneous
2306



nuclear ribonucleoprotein F


P09211_C102
GSTP1 Glutathione S-
2307



transferase P


Q15149_C950
PLEC Plectin
2308


P62195_C209
PSMC5 26S protease
2309



regulatory subunit 8


Q9Y2Q3_C176
GSTK1 Glutathione S-
2310



transferase kappa 1


O15164_C629
TRIM24 Transcription
2311



intermediary factor 1-alpha


P22314_C234
UBA1 Ubiquitin-like modifier-
2312



activating enzyme 1


Q96HE7_C94
ERO1L ERO1-like protein
2313



alpha


P07203_C78
GPX1 Glutathione peroxidase
2314



1


P21964_C238
COMT Catechol O-
2315



methyltransferase


O76071_C72
CIAO1 Probable cytosolic
2316



iron-sulfur protein assembly



protein CIAO1


P04083_C324
ANXA1 Annexin A1
2317


Q14315_C1109
FLNC Filamin-C
2318


Q13526_C57
PIN1 Peptidyl-prolyl cis-trans
2319



isomerase NIMA-interacting 1


Q9Y3B2_C170
EXOSC1 Exosome complex
2320



component CSL4


P54687_C140
BCAT1 Branched-chain-
2321



amino-acid aminotransferase,



cytosolic


Q92945_C379
KHSRP Far upstream element-
2322



binding protein 2


Q13148_C198
TARDBP TAR DNA-binding
2323



protein 43


Q9Y3C4_C167
TPRKB TP53RK-binding
2324



protein


O43175_C281
PHGDH D-3-
2325



phosphoglycerate



dehydrogenase


Q16698_C285
DECR1 2,4-dienoyl-CoA
2326



reductase, mitochondrial


P49773_C38
HINT1 Histidine triad
2327



nucleotide-binding protein 1


P12004_C27
PCNA Proliferating cell
2328



nuclear antigen


P51553_C81
IDH3G Isocitrate
2329



dehydrogenase


Q14192_C214
FHL2 Four and a half LIM
2330



domains protein 2


P07814_C381
EPRS Bifunctional
2331



glutamate/proline--tRNA



ligase


Q8WWY3_C247
PRPF31 U4/U6 small nuclear
2332



ribonucleoprotein Prp31


Q13085_C813
ACACA Acetyl-CoA
2333



carboxylase 1


O43765_C38
SGTA Small glutamine-rich
2334



tetratricopeptide repeat-cont


Q13185_C160
CBX3 Chromobox protein
2335



homolog 3


Q9UBR2_C164
CTSZ Cathepsin Z
2336


P54886_C612
ALDH18A1 Delta-1-pyrroline-
2337



5-carboxylate synthase


Q9H9E3_C494
COG4 Conserved oligomeric
2338



Golgi complex subunit 4


P19623_C209
SRM Spermidine synthase
2339


P61247_C201
RPS3A 40S ribosomal protein
2340



S3a


P15311_C284
EZR Ezrin
2341


P53004_C204
BLVRA Biliverdin reductase
2342



A


Q969E8_C114
TSR2 Pre-rRNA-processing
2343



protein TSR2 homolog


P41252_C350
IARS Isoleucine--tRNA ligase,
2344



cytoplasmic


O60343_C316
TBC1D4 TBC1 domain family
2345



member 4


Q96JB2_C349
COG3 Conserved oligomeric
2346



Golgi complex subunit 3


Q9Y490_C1978
TLN1 Talin-1
2347


P23381_C62
WARS Tryptophan--tRNA
2348



ligase, cytoplasmic


P27708_C280
CAD CAD protein
2349


Q9Y3Z3_C80
SAMHD1 SAM domain and
2350



HD domain-containing protein



1


Q53H96_C49
PYCRL Pyrroline-5-
2351



carboxylate reductase 3


Q9HCC0_C431
MCCC2 Methylcrotonoyl-CoA
2352



carboxylase beta chain,



mitochondrial


P47897_C358
QARS Glutamine--tRNA
2353



ligase


P55084_C435
HADHB Trifunctional enzyme
2354



subunit beta, mitochondrial


P30405_C157
PPIF Peptidyl-prolyl cis-trans
2355



isomerase F, mitochondrial


P08567_C160
PLEK Pleckstrin
2356


A6NHR9_C84
SMCHD1 Structural
2357



maintenance of chromosomes



flexible hinge domain



containing 1


Q9Y2X3_C439
NOP58 Nucleolar protein 58
2358


O00410_C420
IPO5 Importin-5
2359


P09382_C61
LGALS1 Galectin-1
2360


O75150_C950
RNF40 E3 ubiquitin-protein
2361



ligase BRE1B


P11021_C420
HSPA5 78 kDa glucose-
2362



regulated protein


P29401_C133
TKT Transketolase
2363


Q92598_C658
HSPH1 Heat shock protein 105
2364



kDa


O43795_C129
MYO1B Unconventional
2365



myosin-Ib


O75369_C1326
FLNB Filamin-B
2366


Q70E73_C94
RAPH1 Ras-associated and
2367



pleckstrin homology domains-



con


Q0PNE2_C218
ELP6 Elongator complex
2368



protein 6


Q12996_C628
CSTF3 Cleavage stimulation
2369



factor subunit 3


P09543_C49
CNP 2,3-cyclic-nucleotide 3-
2370



phosphodiesterase


Q8WVV9_C405
HNRPLL Heterogeneous
2371



nuclear ribonucleoprotein L-



like


Q8N4X5_C467
AFAP1L2 Actin filament-
2372



associated protein 1-like 2


Q8IUI8_C313
CRLF3 Cytokine receptor-like
2373



factor 3


Q9BPX3_C843
NCAPG Condensin complex
2374



subunit 3


P30566_C27
ADSL Adenylosuccinate lyase
2375


O00469_C494
PLOD2 Procollagen-lysine,2-
2376



oxoglutarate 5-dioxygenase 2


Q92616_C55
GCN1L1 Translational
2377



activator GCN1


P49327_C212
FASN Fatty acid synthase
2378


P42166_C330
TMPO Lamina-associated
2379



polypeptide 2, isoform alpha


P55769_C73
NHP2L1 NHP2-like protein 1
2380


Q9UQ35_C2116
SRRM2 Serine/arginine
2381



repetitive matrix protein 2


P01591_C91
IGJ Immunoglobulin J chain
2382


P61970_C38
NUTF2 Nuclear transport
2383



factor 2


O94953_C547
KDM4B Lysine-specific
2384



demethylase 4B


Q15149_C730
PLEC Plectin
2385


Q9ULW0_C301
TPX2 Targeting protein for
2386



Xklp2


Q9UNF1_C516
MAGED2 Melanoma-
2387



associated antigen D2


P51808_C8
DYNLT3 Dynein light chain
2388



Tctex-type 3


Q09666_C5502
AHNAK Neuroblast
2389



differentiation-associated



protein AHNA


P27348_C25
YWHAQ 14-3-3 protein theta
2390


Q8WUM0_C811
NUP133 Nuclear pore
2391



complex protein Nup133


P52789_C628
HK2 Hexokinase-2
2392


O60716_C618
CTNND1 Catenin delta-1
2393


P26599_C251
PTBP1 Polypyrimidine tract-
2394



binding protein 1


P23528_C147
CFL1 Cofilin-1
2395


Q14694_C94
USP10 Ubiquitin carboxyl-
2396



terminal hydrolase 10


P36507_C384
MAP2K2 Dual specificity
2397



mitogen-activated protein



kinase


Q9UJX3_C259
ANAPC7 Anaphase-promoting
2398



complex subunit 7


Q9BV20_C168
MRI1 Methylthioribose-1-
2399



phosphate isomerase


Q9Y696_C189
CLIC4 Chloride intracellular
2400



channel protein 4


Q6ZMK1_C342
CYHR1 Cysteine and
2401



histidine-rich protein 1


P45954_C139
ACADSB Short/branched
2402



chain specific acyl-CoA



dehydrogena


P15121_C187
AKR1B1 Aldose reductase
2403


Q9NR50_C64
EIF2B3 Translation initiation
2404



factor eIF-2B subunit gamma


Q14980_C1907
NUMA1 Nuclear mitotic
2405



apparatus protein 1


O43707_C793
ACTN4 Alpha-actinin-4
2406


O43707_C879
ACTN4 Alpha-actinin-4
2407


Q9NPA3_C62
MID1IP1 Mid1-interacting
2408



protein 1


Q5UIP0_C2450
RIF1 Telomere-associated
2409



protein RIF1


P41134_C17
ID1 DNA-binding protein
2410



inhibitor ID-1


Q13509_C129
TUBB3 Tubulin beta-3 chain
2411


Q16718_C17
NDUFA5 NADH
2412



dehydrogenase


Q9H6K1_C18
C6orf106 Uncharacterized
2413



protein C6orf106


Q13057_C144
COASY Bifunctional
2414



coenzyme A synthase


P28838_C313
LAP3 Cytosol aminopeptidase
2415


Q96EP0_C504
RNF31 E3 ubiquitin-protein
2416



ligase RNF31


P08107_C17
HSPA1B Heat shock 70 kDa
2417



protein 1A/1B


P27708_C1455
CAD CAD protein
2418


P23497_C309
SP100 Nuclear autoantigen Sp-
2419



100


P11498_C739
PC Pyruvate carboxylase,
2420



mitochondrial


Q02790_C396
FKBP4 Peptidyl-prolyl cis-
2421



trans isomerase FKBP4


P48507_C35
GCLM Glutamate--cysteine
2422



ligase regulatory subunit


P55735_C245
SEC13 Protein SEC13
2423



homolog


P00367_C376
GLUD1 Glutamate
2424



dehydrogenase 1,



mitochondrial


P52701_C1075
MSH6 DNA mismatch repair
2425



protein Msh6


Q14166_C612
TTLL12 Tubulin--tyrosine
2426



ligase-like protein 12


Q6PKG0_C502
LARP1 La-related protein 1
2427


Q9NVS9_C156
PNPO Pyridoxine-5-phosphate
2428



oxidase


Q99873_C93
PRMT1 Protein arginine N-
2429



methyltransferase 1


Q9H4A6_C84
GOLPH3 Golgi
2430



phosphoprotein 3


P78347_C34
GTF2I General transcription
2431



factor II-I


Q96FZ2_C39
C3orf37 UPF0361 protein
2432



C3orf37


O60547_C336
GMDS GDP-mannose 4,6
2433



dehydratase


P62979_C149
RPS27A Ubiquitin-40S
2434



ribosomal protein S27a


P52732_C911
KIF11 Kinesin-like protein
2435



KIF11


P40938_C32
RFC3 Replication factor C
2436



subunit 3


P31943_C34
HNRNPH1 Heterogeneous
2437



nuclear ribonucleoprotein H


Q8N1F7_C422
NUP93 Nuclear pore complex
2438



protein Nup93


Q16643_C96
DBN1 Drebrin
2439


P45880_C76
VDAC2 Voltage-dependent
2440



anion-selective channel protein


Q9BYG5_C13
PARD6B Partitioning
2441



defective 6 homolog beta


P42765_C128
ACAA2 3-ketoacyl-CoA
2442



thiolase, mitochondrial


Q96HC4_C213
PDLIM5 PDZ and LIM
2443



domain protein 5


O15042_C320
U2SURP U2 snRNP-
2444



associated SURP motif-



containing protein


Q96IY1_C224
NSL1 Kinetochore-associated
2445



protein NSL1 homolog


P12270_C1068
TPR Nucleoprotein TPR
2446


P01591_C156
IGJ Immunoglobulin J chain
2447


P53992_C1083
SEC24C Protein transport
2448



protein Sec24C


Q92973_C142
TNPO1 Transportin-1
2449


P32321_C60
DCTD Deoxycytidylate
2450



deaminase


P62195_C112
PSMC5 26S protease
2451



regulatory subunit 8


P31146_C40
CORO1A Coronin-1A
2452


P12814_C774
ACTN1 Alpha-actinin-1
2453


Q04726_C528
TLE3 Transducin-like
2454



enhancer protein 3


Q52LJ0_C216
FAM98B Protein FAM98B
2455


P04083_C270
ANXA1 Annexin A1
2456


O94925_C203
GLS Glutaminase kidney
2457



isoform, mitochondrial


Q9GZP4_C187
PITHD1 PITH domain-
2458



containing protein 1


P33764_C14
S100A3 Protein S100-A3
2459


Q9UKK9_C76
NUDT5 ADP-sugar
2460



pyrophosphatase


P38117_C71
ETFB Electron transfer
2461



flavoprotein subunit beta


O95817_C151
BAG3 BAG family molecular
2462



chaperone regulator 3


Q27J81_C898
INF2 Inverted formin-2
2463


Q9C0C2_C1443
TNKS1BP1 182 kDa
2464



tankyrase-1-binding protein


Q9C0C9_C314
UBE2O Ubiquitin-conjugating
2465



enzyme E2 O


P84090_C69
ERH Enhancer of rudimentary
2466



homolog


Q8TDN6_C52
BRIX1 Ribosome biogenesis
2467



protein BRX1 homolog


P42704_C484
LRPPRC Leucine-rich PPR
2468



motif-containing protein,



mitochondrial


Q9NR56_C53
MBNL1 Muscleblind-like
2469



protein 1


P14678_C43
SNRPB Small nuclear
2470



ribonucleoprotein-associated



protein


Q86VP6_C1134
CAND1 Cullin-associated
2471



NEDD8-dissociated protein 1


P14324_C333
FDPS Farnesyl pyrophosphate
2472



synthase


P07237_C312
P4HB Protein disulfide-
2473



isomerase


Q9BXJ9_C238
NAA15 N-alpha-
2474



acetyltransferase 15, NatA



auxiliary subunit


Q99614_C28
TTC1 Tetratricopeptide repeat
2475



protein 1


Q9UDY2_C914
TJP2 Tight junction protein
2476



ZO-2


Q06210_C254
GFPT1 Glucosamine--
2477



fructose-6-phosphate



aminotransferase


P55199_C14
ELL RNA polymerase II
2478



elongation factor ELL


Q9H2U2_C180
PPA2 Inorganic
2479



pyrophosphatase 2,



mitochondrial


Q6UB35_C779
MTHFD1L Monofunctional
2480



C1-tetrahydrofolate synthase,



mitochondrial


P34897_C80
SHMT2 Serine
2481



hydroxymethyltransferase,



mitochondrial


P13798_C30
APEH Acylamino-acid-
2482



releasing enzyme


O95671_C333
ASMTL N-acetylserotonin O-
2483



methyltransferase-like protein


O95671_C441
ASMTL N-acetylserotonin O-
2484



methyltransferase-like protein


Q9NQW6_C309
ANLN Actin-binding protein
2485



anillin


Q04206_C109
RELA Transcription factor p65
2486


P31350_C202
RRM2 Ribonucleoside-
2487



diphosphate reductase subunit



M2


P08107_C306
HSPA1B Heat shock 70 kDa
2488



protein 1A/1B


O75914_C424
PAK3 Serine/threonine-protein
2489



kinase PAK 3


P27708_C379
CAD CAD protein
2490


P62910_C96
RPL32 60S ribosomal protein
2491



L32


Q9Y570_C347
PPME1 Protein phosphatase
2492



methylesterase 1


Q92499_C110
DDX1 ATP-dependent RNA
2493



helicase DDX1


P30405_C203
PPIF Peptidyl-prolyl cis-trans
2494



isomerase F, mitochondrial


Q92621_C1662
NUP205 Nuclear pore
2495



complex protein Nup205


Q14376_C196
GALE UDP-glucose 4-
2496



epimerase


O75717_C1008
WDHD1 WD repeat and
2497



HMG-box DNA-binding



protein 1


Q03933_C369
HSF2 Heat shock factor
2498



protein 2


Q00535_C290
CDK5 Cyclin-dependent
2499



kinase 5


B5ME19_C753
EIF3CL Eukaryotic translation
2500



initiation factor 3 subunit


Q9NVP2_C189
ASF1B Histone chaperone
2501



ASF1B


Q13018_C1354
PLA2R1 Secretory
2502



phospholipase A2 receptor


Q15181_C242
PPA1 Inorganic
2503



pyrophosphatase


Q7Z5K2_C1170
WAPAL Wings apart-like
2504



protein homolog


Q13642_C71
FHL1 Four and a half LIM
2505



domains protein 1


P48556_C274
PSMD8 26S proteasome non-
2506



ATPase regulatory subunit 8


Q9UBL3_C362
ASH2L Set1/Ash2 histone
2507



methyltransferase complex



subunit


Q8TBB5_C373
KLHDC4 Kelch domain-
2508



containing protein 4


P07339_C329
CTSD Cathepsin D
2509


Q7Z6Z7_C1401
HUWE1 E3 ubiquitin-protein
2510



ligase HUWE1


Q16514_C100
TAF12 Transcription initiation
2511



factor TFIID subunit 12


P63151_C239
PPP2R2A Serine/threonine-
2512



protein phosphatase 2A 55 kDa



regulatory subunit B alpha



isoform


Q7L2H7_C175
EIF3M Eukaryotic translation
2513



initiation factor 3 subunit


Q8NHV4_C66
NEDD1 Protein NEDD1
2514


P13010_C339
XRCC5 X-ray repair cross-
2515



complementing protein 5


P51858_C108
HDGF Hepatoma-derived
2516



growth factor


P26038_C284
MSN Moesin
2517


P68402_C206
PAFAH1B2 Platelet-activating
2518



factor acetylhydrolase IB



subunit


P15407_C97
FOSL1 Fos-related antigen 1
2519


Q12768_C21
KIAA0196 WASH complex
2520



subunit strumpellin


P29144_C28
TPP2 Tripeptidyl-peptidase 2
2521


P78371_C412
CCT2 T-complex protein 1
2522



subunit beta


O60711_C340
LPXN Leupaxin
2523


Q9H9Q2_C110
COPS7B COP9 signalosome
2524



complex subunit 7b


P40261_C165
NNMT Nicotinamide N-
2525



methyltransferase


Q9BWJ5_C76
SF3B5 Splicing factor 3B
2526



subunit 5


P50479_C44
PDLIM4 PDZ and LIM
2527



domain protein 4


Q5JRX3_C556
PITRM1 Presequence
2528



protease, mitochondrial


Q9ULE6_C845
PALD1 Paladin
2529


Q9NXV6_C178
CDKN2AIP CDKN2A-
2530



interacting protein


P13639_C67
EEF2 Elongation factor 2
2531


P04183_C79
TK1 Thymidine kinase,
2532



cytosolic


Q9H8V3_C221
ECT2 Protein ECT2
2533


Q9NPJ6_C162
MED4 Mediator of RNA
2534



polymerase II transcription



subunit


Q5VTR2_C924
RNF20 E3 ubiquitin-protein
2535



ligase BRE1A


O00231_C202
PSMD11 26S proteasome non-
2536



ATPase regulatory subunit 11


P50995_C384
ANXA11 Annexin A11
2537


P62851_C59
RPS25 40S ribosomal protein
2538



S25


Q12906_C203
ILF3 Interleukin enhancer-
2539



binding factor 3


Q13315_C2770
ATM Serine-protein kinase
2540



ATM


P22681_C508
CBL E3 ubiquitin-protein
2541



ligase CBL


P35998_C270
PSMC2 26S protease
2542



regulatory subunit 7


O75570_C137
MTRF1 Peptide chain release
2543



factor 1, mitochondrial


P35579_C1437
MYH9 Myosin-9
2544


P48643_C493
CCT5 T-complex protein 1
2545



subunit epsilon


P52209_C422
PGD 6-phosphogluconate
2546



dehydrogenase,



decarboxylating


Q13155_C306
AIMP2 Aminoacyl tRNA
2547



synthase complex-interacting



multifunctional protein 2


Q14197_C82
ICT1 Peptidyl-tRNA hydrolase
2548



ICT1, mitochondrial


C9J4G0_C66
C17orf49 HCG32827, isoform
2549



CRA_d


P00338_C185
LDHA L-lactate
2550



dehydrogenase A chain


Q9UBQ0_C41
VPS29 Vacuolar protein
2551



sorting-associated protein 29


Q15645_C14
TRIP13 Pachytene checkpoint
2552



protein 2 homolog


Q9H1K1_C69
ISCU Iron-sulfur cluster
2553



assembly enzyme ISCU,



mitochondrial


P30101_C244
PDIA3 Protein disulfide-
2554



isomerase A3


P09884_C1458
POLA1 DNA polymerase
2555



alpha catalytic subunit


Q9NT62_C182
ATG3 Ubiquitin-like-
2556



conjugating enzyme ATG3


Q7L591_C323
DOK3 Docking protein 3
2557


Q6IA86_C487
ELP2 Elongator complex
2558



protein 2


P54819_C40
AK2 Adenylate kinase 2,
2559



mitochondrial


P23610_C110
F8A3 Factor VIII intron 22
2560



protein


P13861_C101
PRKAR2A cAMP-dependent
2561



protein kinase type II-alpha



regulatory subunit


Q96ER3_C366
SAAL1 Protein SAAL1
2562


Q92597_C272
NDRG1 Protein NDRG1
2563


Q6P9B6_C13
KIAA1609 TLD domain-
2564



containing protein KIAA1609


O75663_C14
TIPRL TIP41-like protein
2565


Q05086_C49
UBE3A Ubiquitin-protein
2566



ligase E3A


Q14152_C78
EIF3A Eukaryotic translation
2567



initiation factor 3 subunit


P63244_C207
GNB2L1 Guanine nucleotide-
2568



binding protein subunit beta-2-



like 1


Q13509_C201
TUBB3 Tubulin beta-3 chain
2569


Q9Y6A5_C502
TACC3 Transforming acidic
2570



coiled-coil-containing protein


Q86W42_C314
THOC6 THO complex subunit
2571



6 homolog


Q92878_C157
RAD50 DNA repair protein
2572



RAD50


O75879_C228
PET112 Glutamyl-tRNA(Gln)
2573



amidotransferase subunit B,



mitochondrial


Q9UHB9_C562
SRP68 Signal recognition
2574



particle 68 kDa protein


P41250_C155
GARS Glycine--tRNA ligase
2575


P46821_C1814
MAP1B Microtubule-
2576



associated protein 1B


O14980_C723
XPO1 Exportin-1
2577


P13796_C164
LCP1 Plastin-2
2578


P13796_C336
LCP1 Plastin-2
2579


Q9Y2L1_C533
DIS3 Exosome complex
2580



exonuclease RRP44


Q9NQW6_C96
ANLN Actin-binding protein
2581



anillin


P43246_C176
MSH2 DNA mismatch repair
2582



protein Msh2


Q9Y4L1_C352
HYOU1 Hypoxia up-regulated
2583



protein 1


P15153_C105
RAC2 Ras-related C3
2584



botulinum toxin substrate 2


Q9H0G5_C232
NSRP1 Nuclear speckle
2585



splicing regulatory protein 1


P48507_C194
GCLM Glutamate--cysteine
2586



ligase regulatory subunit


Q9BRX5_C188
GINS3 DNA replication
2587



complex GINS protein PSF3


Q9NR09_C543
BIRC6 Baculoviral IAP
2588



repeat-containing protein 6


Q13813_C1314
SPTAN1 Spectrin alpha chain,
2589



non-erythrocytic 1


Q10713_C466
PMPCA Mitochondrial-
2590



processing peptidase subunit



alpha


Q9H7N4_C1098
SCAF1 Splicing factor,
2591



arginine/serine-rich 19


Q9NXA8_C303
SIRT5 NAD-dependent protein
2592



deacylase sirtuin-5,



mitochondrial


P83916_C60
CBX1 Chromobox protein
2593



homolog 1


O00410_C110
IPO5 Importin-5
2594


P57764_C457
GSDMD Gasdermin-D
2595


P15170_C327
GSPT1 Eukaryotic peptide
2596



chain release factor GTP-



binding


Q9BWD1_C360
ACAT2 Acetyl-CoA
2597



acetyltransferase, cytosolic


P04818_C180
TYMS Thymidylate synthase
2598


Q9BQ69_C276
MACROD1 O-acetyl-ADP-
2599



ribose deacetylase MACROD1


Q01970_C834
PLCB3 1-phosphatidylinositol
2600



4,5-bisphosphate phosphodie


Q9Y6E0_C394
STK24 Serine/threonine-
2601



protein kinase 24


P53634_C136
CTSC Dipeptidyl peptidase 1
2602


Q9UGP4_C431
LIMD1 LIM domain-
2603



containing protein 1


O75369_C455
FLNB Filamin-B
2604


P21980_C554
TGM2 Protein-glutamine
2605



gamma-glutamyltransferase 2


P30281_C47
CCND3 G1/S-specific cyclin-
2606



D3


P49790_C1129
NUP153 Nuclear pore
2607



complex protein Nup153


Q93008_C673
USP9X Probable ubiquitin
2608



carboxyl-terminal hydrolase



FAF


Q9Y613_C31
FHOD1 FH1/FH2 domain-
2609



containing protein 1


Q9BXB5_C203
OSBPL10 Oxysterol-binding
2610



protein-related protein 10


P62633_C97
CNBP Cellular nucleic acid-
2611



binding protein


Q14005_C1016
IL16 Pro-interleukin-16
2612


Q9UPQ0_C863
LIMCH1 LIM and calponin
2613



homology domains-containing



protein


Q9HD26_C408
GOPC Golgi-associated PDZ
2614



and coiled-coil motif-



containing


P07900_C481
HSP90AA1 Heat shock protein
2615



HSP 90-alpha


P21333_C717
FLNA Filamin-A
2616


P21333_C2582
FLNA Filamin-A
2617


P13010_C235
XRCC5 X-ray repair cross-
2618



complementing protein 5


O95347_C46
SMC2 Structural maintenance
2619



of chromosomes protein 2


P68402_C188
PAFAH1B2 Platelet-activating
2620



factor acetylhydrolase IB



subunit


P61962_C256
DCAF7 DDB1- and CUL4-
2621



associated factor 7


P49327_C1118
FASN Fatty acid synthase
2622


P49321_C84
NASP Nuclear autoantigenic
2623



sperm protein


Q14019_C52
COTL1 Coactosin-like protein
2624


Q9NYK5_C335
MRPL39 39S ribosomal
2625



protein L39, mitochondrial


P55160_C338
NCKAP1L Nck-associated
2626



protein 1-like


P10599_C69
TXN Thioredoxin
2627


P14921_C31
ETS1 Protein C-ets-1
2628


Q8NBJ5_C412
GLT25D1 Procollagen
2629



galactosyltransferase 1


Q13200_C448
PSMD2 26S proteasome non-
2630



ATPase regulatory subunit 2


Q9ULW0_C364
TPX2 Targeting protein for
2631



Xklp2


P09914_C138
IFIT1 Interferon-induced
2632



protein with tetratricopeptide


O14744_C449
PRMT5 Protein arginine N-
2633



methyltransferase 5


Q6NXT1_C230
ANKRD54 Ankyrin repeat
2634



domain-containing protein 54


Q5VT52_C649
RPRD2 Regulation of nuclear
2635



pre-mRNA domain-containing



P


P22314_C200
UBA1 Ubiquitin-like modifier-
2636



activating enzyme 1


P22314_C431
UBA1 Ubiquitin-like modifier-
2637



activating enzyme 1


Q8IU81_C280
IRF2BP1 Interferon regulatory
2638



factor 2-binding protein 1


Q5T160_C576
RARS2 Probable arginine--
2639



tRNA ligase, mitochondrial


Q86UV5_C986
USP48 Ubiquitin carboxyl-
2640



terminal hydrolase 48


P04083_C343
ANXA1 Annexin A1
2641


Q8NFF5_C236
FLAD1 FAD synthase
2642


P04150_C367
NR3C1 Glucocorticoid
2643



receptor


Q9H269_C490
VPS16 Vacuolar protein
2644



sorting-associated protein 16



homolog


Q969Z0_C417
TBRG4 Protein TBRG4
2645


Q9ULC4_C113
MCTS1 Malignant T-cell-
2646



amplified sequence 1


Q15306_C343
IRF4 Interferon regulatory
2647



factor 4


Q15013_C124
MAD2L1BP MAD2L1-
2648



binding protein


P45974_C532
USP5 Ubiquitin carboxyl-
2649



terminal hydrolase 5


O95817_C179
BAG3 BAG family molecular
2650



chaperone regulator 3


Q99797_C687
MIPEP Mitochondrial
2651



intermediate peptidase


P35579_C896
MYH9 Myosin-9
2652


O94855_C853
SEC24D Protein transport
2653



protein Sec24D


O14965_C393
AURKA Aurora kinase A
2654


Q9BQA1_C65
WDR77 Methylosome protein
2655



50


Q27J81_C284
INF2 Inverted formin-2
2656


P30048_C108
PRDX3 Thioredoxin-
2657



dependent peroxide reductase,



mitochondrial


P22102_C646
GART Trifunctional purine
2658



biosynthetic protein adenosin


P62316_C63
SNRPD2 Small nuclear
2659



ribonucleoprotein Sm D2


P09884_C141
POLA1 DNA polymerase
2660



alpha catalytic subunit


Q7L591_C493
DOK3 Docking protein 3
2661


O00159_C161
MYO1C Unconventional
2662



myosin-Ic


O00151_C73
PDLIM1 PDZ and LIM
2663



domain protein 1


O00151_C263
PDLIM1 PDZ and LIM
2664



domain protein 1


P62136_C171
PPP1CA Serine/threonine-
2665



protein phosphatase PP1-alpha



catalytic subunit


P55060_C853
CSE1L Exportin-2
2666


O95232_C58
LUC7L3 Luc7-like protein 3
2667


P29590_C338
PML Protein PML
2668


Q8IXK0_C673
PHC2 Polyhomeotic-like
2669



protein 2


Q14980_C1729
NUMA1 Nuclear mitotic
2670



apparatus protein 1


P63244_C286
GNB2L1 Guanine nucleotide-
2671



binding protein subunit beta-2-



like 1


P62333_C347
PSMC6 26S protease
2672



regulatory subunit 10B R


Q13501_C113
SQSTM1 Sequestosome-1
2673


P60866_C36
RPS20 40S ribosomal protein
2674



S20


Q969E8_C17
TSR2 Pre-rRNA-processing
2675



protein TSR2 homolog


Q93052_C262
LPP Lipoma-preferred partner
2676


P08758_C316
ANXA5 Annexin A5
2677


O75616_C150
ERAL1 GTPase Era,
2678



mitochondrial


Q9UHB9_C525
SRP68 Signal recognition
2679



particle 68 kDa protein


Q9H223_C175
EHD4 EH domain-containing
2680



protein 4


P08107_C603
HSPA1B Heat shock 70 kDa
2681



protein 1A/1B


P27708_C183
CAD CAD protein
2682


Q9Y4L1_C805
HYOU1 Hypoxia up-regulated
2683



protein 1


P26358_C1125
DNMT1 DNA (cytosine-5)-
2684



methyltransferase 1


P36954_C52
POLR2I DNA-directed RNA
2685



polymerase II subunit RPB9


P49748_C156
ACADVL Very long-chain
2686



specific acyl-CoA



dehydrogenase, mitochondrial


Q9H2G2_C1212
SLK STE20-like
2687



serine/threonine-protein kinase


P35268_C25
RPL22 60S ribosomal protein
2688



L22


P46939_C539
UTRN Utrophin
2689


P49368_C173
CCT3 T-complex protein 1
2690



subunit gamma


P50135_C82
HNMT Histamine N-
2691



methyltransferase


Q6Y7W6_C938
GIGYF2 PERQ amino acid-
2692



rich with GYF domain-



containing protein 2


O95861_C59
BPNT1 3(2),5-bisphosphate
2693



nucleotidase 1


P49023_C290
PXN Paxillin
2694


Q99873_C216
PRMT1 Protein arginine N-
2695



methyltransferase 1


P02765_C132
AHSG Alpha-2-HS-
2696



glycoprotein


Q9H3M7_C120
TXNIP Thioredoxin-
2697



interacting protein


Q9UPN3_C4825
MACF1 Microtubule-actin
2698



cross-linking factor 1, isoforms


Q9UPN9_C150
TRIM33 E3 ubiquitin-protein
2699



ligase TRIM33


O75369_C1158
FLNB Filamin-B
2700


P56545_C140
CTBP2 C-terminal-binding
2701



protein 2


Q00341_C948
HDLBP Vigilin
2702


P35250_C171
RFC2 Replication factor C
2703



subunit 2


P46013_C1285
MKI67 Antigen KI-67
2704


O75083_C225
WDR1 WD repeat-containing
2705



protein 1


O43252_C165
PAPSS1 Bifunctional 3-
2706



phosphoadenosine 5-



phosphosulfate


Q16512_C317
PKN1 Serine/threonine-protein
2707



kinase N1


Q16881_C339
TXNRD1 Thioredoxin
2708



reductase 1, cytoplasmic


P21333_C478
FLNA Filamin-A
2709


P21333_C2378
FLNA Filamin-A
2710


O00268_C867
TAF4 Transcription initiation
2711



factor TFIID subunit 4


O95340_C117
PAPSS2 Bifunctional 3-
2712



phosphoadenosine 5-



phosphosulfate


P42765_C382
ACAA2 3-ketoacyl-CoA
2713



thiolase, mitochondrial


Q9UI12_C85
ATP6V1H V-type proton
2714



ATPase subunit H


Q05655_C127
PRKCD Protein kinase C delta
2715



type


P42166_C629
TMPO Lamina-associated
2716



polypeptide 2, isoform alpha


O14929_C27
HAT1 Histone
2717



acetyltransferase type B



catalytic subunit L


Q9NYK5_C133
MRPL39 39S ribosomal
2718



protein L39, mitochondrial


O60234_C96
GMFG Glia maturation factor
2719



gamma


F8VZW7_C74
Uncharacterized protein
2720


Q12888_C1040
TP53BP1 Tumor suppressor
2721



p53-binding protein 1


Q5JTZ9_C609
AARS2 Alanine--tRNA ligase,
2722



mitochondrial


Q9Y383_C44
LUC7L2 Putative RNA-
2723



binding protein Luc7-like 2


Q6P1R3_C99
MSANTD2 Myb/SANT-like
2724



DNA-binding domain-



containing protei


Q99832_C364
CCT7 T-complex protein 1
2725



subunit eta


Q9NRW4_C124
DUSP22 Dual specificity
2726



protein phosphatase 22


Q8N163_C238
KIAA1967 DBIRD complex
2727



subunit KIAA1967


Q8N163_C443
KIAA1967 DBIRD complex
2728



subunit KIAA1967


Q15149_C1136
PLEC Plectin
2729


Q15149_C4454
PLEC Plectin
2730


P31146_C285
CORO1A Coronin-1A
2731


Q16555_C248
DPYSL2
2732



Dihydropyrimidinase-related



protein 2


Q99567_C713
NUP88 Nuclear pore complex
2733



protein Nup88


P21964_C119
COMT Catechol O-
2734



methyltransferase


P62857_C27
RPS28 40S ribosomal protein
2735



S28


Q9P287_C275
BCCIP BRCA2 and
2736



CDKN1A-interacting protein


Q7LBC6_C1470
KDM3B Lysine-specific
2737



demethylase 3B


P62140_C171
PPP1CB Serine/threonine-
2738



protein phosphatase PP1-beta



catalytic subunit


P33764_C68
S100A3 Protein S100-A3
2739


Q9UBQ7_C123
GRHPR Glyoxylate
2740



reductase/hydroxypyruvate



reductase


Q9UJY4_C343
GGA2 ADP-ribosylation
2741



factor-binding protein GGA2


O60841_C1092
EIF5B Eukaryotic translation
2742



initiation factor 5B


Q92945_C296
KHSRP Far upstream element-
2743



binding protein 2


Q9HAV4_C941
XPO5 Exportin-5
2744


O14964_C185
HGS Hepatocyte growth
2745



factor-regulated tyrosine



kinase


P23526_C195
AHCY
2746



Adenosylhomocysteinase


P52209_C289
PGD 6-phosphogluconate
2747



dehydrogenase,



decarboxylating


Q9Y697_C381
NFS1 Cysteine desulfurase,
2748



mitochondrial


Q9Y520_C177
PRRC2C Protein PRRC2C
2749


Q9H910_C118
HN1L Hematological and
2750



neurological expressed 1-like



protein


Q6FI81_C92
CIAPIN1 Anamorsin
2751


Q8WZA9_C340
IRGQ Immunity-related
2752



GTPase family Q protein


Q8NDH3_C81
NPEPL1 Probable
2753



aminopeptidase NPEPL1


O00571_C317
DDX3X ATP-dependent RNA
2754



helicase DDX3X


P05091_C179
ALDH2 Aldehyde
2755



dehydrogenase, mitochondrial


P05091_C472
ALDH2 Aldehyde
2756



dehydrogenase, mitochondrial


O15235_C132
MRPS12 28S ribosomal
2757



protein S12, mitochondrial


P42704_C130
LRPPRC Leucine-rich PPR
2758



motif-containing protein,



mitochondrial


Q99590_C566
SCAF11 Protein SCAF11
2759


Q9NR56_C19
MBNL1 Muscleblind-like
2760



protein 1


Q9P2E9_C1038
RRBP1 Ribosome-binding
2761



protein 1


P52888_C682
THOP1 Thimet oligopeptidase
2762


P55212_C264
CASP6 Caspase-6
2763


Q6IBW4_C342
NCAPH2 Condensin-2
2764



complex subunit H2


P18754_C352
RCC1 Regulator of
2765



chromosome condensation


Q8TB52_C433
FBXO30 F-box only protein
2766



30


Q32MZ4_C644
LRRFIP1 Leucine-rich repeat
2767



flightless-interacting protein


Q9NYL2_C150
MLTK Mitogen-activated
2768



protein kinase kinase kinase



MLT


Q15393_C1156
SF3B3 Splicing factor 3B
2769



subunit 3


P63244_C168
GNB2L1 Guanine nucleotide-
2770



binding protein subunit beta-2-



like 1


Q53EL6_C275
PDCD4 Programmed cell
2771



death protein 4


P56537_C152
EIF6 Eukaryotic translation
2772



initiation factor 6


P09622_C484
DLD Dihydrolipoyl
2773



dehydrogenase, mitochondrial


Q9Y314_C185
NOSIP Nitric oxide synthase-
2774



interacting protein


Q96P16_C151
RPRD1A Regulation of
2775



nuclear pre-mRNA domain-



containing p


P46821_C2041
MAP1B Microtubule-
2776



associated protein 1B


O60343_C266
TBC1D4 TBC1 domain family
2777



member 4


Q96EB1_C361
ELP4 Elongator complex
2778



protein 4


Q86WB0_C102
ZC3HC1 Nuclear-interacting
2779



partner of ALK


P49915_C104
GMPS GMP synthase
2780


O75608_C144
LYPLA1 Acyl-protein
2781



thioesterase 1


P11498_C131
PC Pyruvate carboxylase,
2782



mitochondrial


P11498_C752
PC Pyruvate carboxylase,
2783



mitochondrial


Q53H96_C266
PYCRL Pyrroline-5-
2784



carboxylate reductase 3


Q96DE5_C55
ANAPC16 Anaphase-
2785



promoting complex subunit 16


Q96KB5_C112
PBK Lymphokine-activated
2786



killer T-cell-originated prot


P55084_C458
HADHB Trifunctional enzyme
2787



subunit beta, mitochondrial


P55735_C234
SEC13 Protein SEC13
2788



homolog


P56192_C287
MARS Methionine--tRNA
2789



ligase, cytoplasmic


P07384_C115
CAPN1 Calpain-1 catalytic
2790



subunit


P08559_C222
PDHA1 Pyruvate
2791



dehydrogenase E1 component



subunit alpha,


Q99714_C91
HSD17B10 3-hydroxyacyl-
2792



CoA dehydrogenase type-2


P33992_C197
MCM5 DNA replication
2793



licensing factor MCM5


P49757_C611
NUMB Protein numb homolog
2794


O15269_C438
SPTLC1 Serine
2795



palmitoyltransferase 1


O75935_C173
DCTN3 Dynactin subunit 3
2796


Q8IU85_C182
CAMK1D
2797



Calcium/calmodulin-dependent



protein kinase type 1


Q05519_C455
SRSF11 Serine/arginine-rich
2798



splicing factor 11


P36578_C125
RPL4 60S ribosomal protein
2799



L4


Q96E14_C95
RMI2 RecQ-mediated genome
2800



instability protein 2


Q96N67_C457
DOCK7 Dedicator of
2801



cytokinesis protein 7


Q7Z5K2_C160
WAPAL Wings apart-like
2802



protein homolog


P41214_C489
EIF2D Eukaryotic translation
2803



initiation factor 2D


O43242_C483
PSMD3 26S proteasome non-
2804



ATPase regulatory subunit 3


O75369_C1280
FLNB Filamin-B
2805


Q8IWI9_C2974
MGA MAX gene-associated
2806



protein


O15067_C785
PFAS
2807



Phosphoribosylformylglycinamidine



synthase


Q96GX9_C16
APIP Probable
2808



methylthioribulose-1-



phosphate dehydratase


Q9BXP5_C412
SRRT Serrate RNA effector
2809



molecule homolog


O75083_C382
WDR1 WD repeat-containing
2810



protein 1


Q8WVV9_C535
HNRPLL Heterogeneous
2811



nuclear ribonucleoprotein L-



like


Q7Z6Z7_C1891
HUWE1 E3 ubiquitin-protein
2812



ligase HUWE1


Q7Z6Z7_C3296
HUWE1 E3 ubiquitin-protein
2813



ligase HUWE1


Q14008_C1500
CKAP5 Cytoskeleton-
2814



associated protein 5


Q9H3P2_C44
WHSC2 Negative elongation
2815



factor A


Q8NB37_C154
PDDC1 Parkinson disease 7
2816



domain-containing protein 1


P48047_C141
ATP5O ATP synthase subunit
2817



O, mitochondrial


Q8IUI8_C95
CRLF3 Cytokine receptor-like
2818



factor 3


Q9H6S3_C261
EPS8L2 Epidermal growth
2819



factor receptor kinase substrate


P21333_C53
FLNA Filamin-A
2820


Q5T4S7_C3864
UBR4 E3 ubiquitin-protein
2821



ligase UBR4


P46060_C82
RANGAP1 Ran GTPase-
2822



activating protein 1


O14929_C299
HAT1 Histone
2823



acetyltransferase type B



catalytic subunit


P48059_C272
LIMS1 LIM and senescent cell
2824



antigen-like-containing



domains 1


O15042_C65
U2SURP U2 snRNP-
2825



associated SURP motif-



containing protein


Q7L2J0_C244
MEPCE 7SK snRNA
2826



methylphosphate capping



enzyme


Q4G176_C399
ACSF3 Acyl-CoA synthetase
2827



family member 3,



mitochondrial


Q9H1B7_C504
IRF2BPL Interferon regulatory
2828



factor 2-binding protein-lik


O95425_C26
SVIL Supervillin
2829


O75351_C240
VPS4B Vacuolar protein
2830



sorting-associated protein 4B


Q96DC7_C57
TMCO6 Transmembrane and
2831



coiled-coil domain-containing



pr


Q9ULW0_C594
TPX2 Targeting protein for
2832



Xklp2


P50502_C209
ST13 Hsc70-interacting
2833



protein


P31146_C51
CORO1A Coronin-1A
2834


P31146_C345
CORO1A Coronin-1A
2835


Q9H2M9_C67
RAB3GAP2 Rab3 GTPase-
2836



activating protein non-catalytic



subunit


Q9UKV3_C546
ACIN1 Apoptotic chromatin
2837



condensation inducer in the



nucleus


P78527_C1229
PRKDC DNA-dependent
2838



protein kinase catalytic subunit


P78527_C1364
PRKDC DNA-dependent
2839



protein kinase catalytic subunit


P42566_C657
EPS15 Epidermal growth
2840



factor receptor substrate 15


P61981_C112
YWHAG 14-3-3 protein
2841



gamma


P20810_C381
CAST Calpastatin
2842


P55036_C58
PSMD4 26S proteasome non-
2843



ATPase regulatory subunit 4


P50991_C295
CCT4 T-complex protein 1
2844



subunit delta


Q96TA1_C230
FAM129B Niban-like protein
2845



1


P49848_C141
TAF6 Transcription initiation
2846



factor TFIID subunit 6


Q14315_C1066
FLNC Filamin-C
2847


O94925_C525
GLS Glutaminase kidney
2848



isoform, mitochondrial


Q92796_C519
DLG3 Disks large homolog 3
2849


O95571_C219
ETHE1 Protein ETHE1,
2850



mitochondrial


Q9ULU8_C800
CADPS Calcium-dependent
2851



secretion activator 1


P50453_C335
SERPINB9 Serpin B9
2852


O95999_C215
BCL10 B-cell
2853



lymphoma/leukemia 10


Q9H4Z3_C29
PCIF1 Phosphorylated CTD-
2854



interacting factor 1


P22692_C204
IGFBP4 Insulin-like growth
2855



factor-binding protein 4


O00148_C223
DDX39A ATP-dependent
2856



RNA helicase DDX39A


Q5VYK3_C814
ECM29 Proteasome-associated
2857



protein ECM29 homolog


Q9NVE7_C537
PANK4 Pantothenate kinase 4
2858


O95801_C63
TTC4 Tetratricopeptide repeat
2859



protein 4


Q14204_C2142
DYNC1H1 Cytoplasmic
2860



dynein 1 heavy chain 1


P48735_C418
IDH2 Isocitrate dehydrogenase
2861


O15371_C258
EIF3D Eukaryotic translation
2862



initiation factor 3 subunit


O00571_C128
DDX3X ATP-dependent RNA
2863



helicase DDX3X


Q8WVC0_C530
LEO1 RNA polymerase-
2864



associated protein LEO1


O15235_C64
MRPS12 28S ribosomal
2865



protein S12, mitochondrial


Q9P2I0_C621
CPSF2 Cleavage and
2866



polyadenylation specificity



factor subunit


Q9H4X1_C33
RGCC Regulator of cell cycle
2867



RGCC


Q7L5N1_C299
COPS6 COP9 signalosome
2868



complex subunit 6


Q6NYC8_C611
PPP1R18 Phostensin
2869


P22626_C50
HNRNPA2B1 Heterogeneous
2870



nuclear ribonucleoproteins



A2/B1


P55072_C105
VCP Transitional endoplasmic
2871



reticulum ATPase


P11912_C196
CD79A B-cell antigen receptor
2872



complex-associated protein


Q9NSE4_C91
IARS2 Isoleucine--tRNA
2873



ligase, mitochondrial


Q9NSE4_C819
IARS2 Isoleucine--tRNA
2874



ligase, mitochondrial


Q9NYF8_C688
BCLAF1 Bcl-2-associated
2875



transcription factor 1


Q15393_C750
SF3B3 Splicing factor 3B
2876



subunit 3


Q16576_C166
RBBP7 Histone-binding
2877



protein RBBP7


Q9NZB2_C279
FAM120A Constitutive
2878



coactivator of PPAR-gamma-



like protein 1


Q15052_C25
ARHGEF6 Rho guanine
2879



nucleotide exchange factor 6


P09622_C80
DLD Dihydrolipoyl
2880



dehydrogenase, mitochondrial


Q96EP0_C551
RNF31 E3 ubiquitin-protein
2881



ligase RNF31


P50579_C121
METAP2 Methionine
2882



aminopeptidase 2


Q7Z434_C133
MAVS Mitochondrial
2883



antiviral-signaling protein


Q29RF7_C327
PDS5A Sister chromatid
2884



cohesion protein PDS5



homolog A


Q86WB0_C406
ZC3HC1 Nuclear-interacting
2885



partner of ALK


Q9Y490_C1953
TLN1 Talin-1
2886


P43243_C230
MATR3 Matrin-3
2887


P62913_C72
RPL11 60S ribosomal protein
2888



L11


O00422_C26
SAP18 Histone deacetylase
2889



complex subunit SAP18


O60921_C200
HUS1 Checkpoint protein
2890



HUS1


O96017_C385
CHEK2 Serine/threonine-
2891



protein kinase Chk2


P36969_C93
GPX4 Phospholipid
2892



hydroperoxide glutathione



peroxidase,


Q96IZ0_C173
PAWR PRKC apoptosis WT1
2893



regulator protein


P36871_C101
PGM1 Phosphoglucomutase-1
2894


Q9BXF6_C337
RAB11FIP5 Rab11 family-
2895



interacting protein 5


Q99873_C262
PRMT1 Protein arginine N-
2896



methyltransferase 1


P09382_C43
LGALS1 Galectin-1
2897


O75934_C132
BCAS2 Pre-mRNA-splicing
2898



factor SPF27


Q92538_C685
GBF1 Golgi-specific brefeldin
2899



A-resistance guanine



nucleotide exchange factor 1


P55039_C99
DRG2 Developmentally-
2900



regulated GTP-binding protein



2


O43414_C285
ERI3 ERI1 exoribonuclease 3
2901


Q14974_C228
KPNB1 Importin subunit beta-
2902



1


P30050_C17
RPL12 60S ribosomal protein
2903



L12


P78347_C475
GTF2I General transcription
2904



factor II-I


Q9H3M7_C247
TXNIP Thioredoxin-
2905



interacting protein


P08047_C68
SP1 Transcription factor Sp1
2906


O43242_C210
PSMD3 26S proteasome non-
2907



ATPase regulatory subunit 3


Q9UPN3_C4206
MACF1 Microtubule-actin
2908



cross-linking factor 1, isoforms


Q14103_C126
HNRNPD Heterogeneous
2909



nuclear ribonucleoprotein D0


Q9BY32_C33
ITPA Inosine triphosphate
2910



pyrophosphatase


Q9BQ52_C670
ELAC2 Zinc
2911



phosphodiesterase ELAC



protein 2


O15067_C318
PFAS
2912



Phosphoribosylformylglycinamidine



synthase


Q9H9J2_C53
MRPL44 39S ribosomal
2913



protein L44, mitochondrial


Q00610_C151
CLTC Clathrin heavy chain 1
2914


P09497_C199
CLTB Clathrin light chain B
2915


Q9Y617_C224
PSAT1 Phosphoserine
2916



aminotransferase


P46013_C1007
MKI67 Antigen KI-67
2917


Q9BSD7_C101
NTPCR Cancer-related
2918



nucleoside-triphosphatase


Q7Z6Z7_C349
HUWE1 E3 ubiquitin-protein
2919



ligase HUWE1


Q14919_C54
DRAP1 Dr1-associated
2920



corepressor


Q9UNE7_C199
STUB1 E3 ubiquitin-protein
2921



ligase CHIP


Q16881_C515
TXNRD1 Thioredoxin
2922



reductase 1, cytoplasmic


P09936_C220
UCHL1 Ubiquitin carboxyl-
2923



terminal hydrolase isozyme L1


Q9NZJ9_C147
NUDT4 Diphosphoinositol
2924



polyphosphate



phosphohydrolase 2


Q5T4S7_C2554
UBR4 E3 ubiquitin-protein
2925



ligase UBR4


Q96C19_C53
EFHD2 EF-hand domain-
2926



containing protein D2


Q8N6M0_C292
OTUD6B OTU domain-
2927



containing protein 6B


Q8N201_C1633
INTS1 Integrator complex
2928



subunit 1


O95294_C301
RASAL1 RasGAP-activating-
2929



like protein 1


Q9UKX7_C181
NUP50 Nuclear pore complex
2930



protein Nup50


Q92616_C1595
GCN1L1 Translational
2931



activator GCN1


P49327_C2024
FASN Fatty acid synthase
2932


Q16877_C106
PFKFB4 6-phosphofructo-2-
2933



kinase/fructose-2,6-



bisphosphatase


Q96JP5_C182
ZFP91 E3 ubiquitin-protein
2934



lgase ZFP91


Q99538_C50
LGMN Legumain
2935


Q96RS6_C32
NUDCD1 NudC domain-
2936



containing protein 1


Q96RS6_C513
NUDCD1 NudC domain-
2937



containing protein 1


Q8TBC4_C28
UBA3 NEDD8-activating
2938



enzyme E1 catalytic subunit


Q14839_C1827
CHD4 Chromodomain-
2939



helicase-DNA-binding protein



4


Q9Y2D5_C205
AKAP2 A-kinase anchor
2940



protein 2


Q9UQ35_C956
SRRM2 Serine/arginine
2941



repetitive matrix protein 2


O60711_C358
LPXN Leupaxin
2942


Q00013_C454
MPP1 55 kDa erythrocyte
2943



membrane protein


Q6P1L8_C57
MRPL14 39S ribosomal
2944



protein L14, mitochondrial


Q92973_C620
TNPO1 Transportin-1
2945


P42575_C320
CASP2 Caspase-2
2946


P35520_C431
CBS Cystathionine beta-
2947



synthase


O95425_C1237
SV1L Supervillin
2948


Q9Y305_C299
ACOT9 Acyl-coenzyme A
2949



thioesterase 9, mitochondrial


P32321_C83
DCTD Deoxycytidylate
2950



deaminase


P61158_C189
ACTR3 Actin-related protein 3
2951


P11413_C158
G6PD Glucose-6-phosphate 1-
2952



dehydrogenase


P04181_C93
OAT Ornithine
2953



aminotransferase,



mitochondrial


P15880_C182
RPS2 40S ribosomal protein
2954



S2


P01871_C88
IGHM Ig mu chain C region
2955


P50991_C120
CCT4 T-complex protein 1
2956



subunit delta


P57678_C210
GEMIN4 Gem-associated
2957



protein 4


O94925_C287
GLS Glutaminase kidney
2958



isoform, mitochondrial


Q8N3D4_C1364
EHBP1L1 EH domain-binding
2959



protein 1-like protein 1


Q8IUF8_C19
MINA MYC-induced nuclear
2960



antigen


Q9NXH9_C376
TRMT1 tRNA (guanine(26)-
2961



N(2))-dimethyltransferase


P00505_C382
GOT2 Aspartate
2962



aminotransferase,



mitochondrial


A0JLT2_C62
MED19 Mediator of RNA
2963



polymerase II transcription



subunit


O15382_C135
BCAT2 Branched-chain-
2964



amino-acid aminotransferase,



mitochondrial


P52789_C606
HK2 Hexokinase-2
2965


Q9Y3C8_C116
UFC1 Ubiquitin-fold modifier-
2966



conjugating enzyme 1


Q13439_C1269
GOLGA4 Golgin subfamily A
2967



member 4


P63279_C43
UBE2I SUMO-conjugating
2968



enzyme UBC9


P60900_C47
PSMA6 Proteasome subunit
2969



alpha type-6


Q9H0L4_C222
CSTF2T Cleavage stimulation
2970



factor subunit 2 tau variant


Q86UX7_C128
FERMT3 Fermitin family
2971



homolog 3


Q15003_C714
NCAPH Condensin complex
2972



subunit 2


O60684_C253
KPNA6 Importin subunit
2973



alpha-7


O75643_C1580
SNRNP200 U5 small nuclear
2974



ribonucleoprotein 200 kDa



helicas


O43765_C129
SGTA Small glutamine-rich
2975



tetratricopeptide repeat-



containing, alpha


Q9GZV5_C363
WWTR1 WW domain-
2976



containing transcription



regulator protein 1


P27816_C654
MAP4 Microtubule-associated
2977



protein 4


Q14847_C53
LASP1 LIM and SH3 domain
2978



protein 1


O15371_C195
EIF3D Eukaryotic translation
2979



initiation factor 3 subunit


P10768_C181
ESD S-formylglutathione
2980



hydrolase


P52895_C242
AKR1C2 Aldo-keto reductase
2981



family 1 member C2


Q9UBE0_C303
SAE1 SUMO-activating
2982



enzyme subunit 1


P29590_C204
PML Protein PML
2983


O15231_C262
ZNF185 Zinc finger protein
2984



185


O75251_C183
NDUFS7 NADH
2985



dehydrogenase


Q01082_C1900
SPTBN1 Spectrin beta chain,
2986



non-erythrocytic 1


Q9UHR5_C127
SAP30BP SAP30-binding
2987



protein


Q9NR56_C43
MBNL1 Muscleblind-like
2988



protein 1


Q9P2E9_C892
RRBP1 Ribosome-binding
2989



protein 1


Q9P2E9_C933
RRBP1 Ribosome-binding
2990



protein 1


Q9P2E9_C1057
RRBP1 Ribosome-binding
2991



protein 1


P13640_C38
MT1G Metallothionein-1G
2992


Q9NSE4_C311
IARS2 Isoleucine--tRNA
2993



ligase, mitochondrial


Q9Y2X7_C576
GIT1 ARF GTPase-activating
2994



protein GIT1


Q9H840_C44
GEMIN7 Gem-associated
2995



protein 7


P14678_C45
SNRPB Small nuclear
2996



ribonucleoprotein-associated



protein


P28340_C428
POLD1 DNA polymerase delta
2997



catalytic subunit


P28347_C53
TEAD1 Transcriptional
2998



enhancer factor TEF-1


P32780_C246
GTF2H1 General transcription
2999



factor IIH subunit 1


Q86VP6_C71
CAND1 Cullin-associated
3000



NEDD8-dissociated protein 1


Q92597_C394
NDRG1 Protein NDRG1
3001


Q8IW35_C484
CEP97 Centrosomal protein of
3002



97 kDa


Q96JB5_C216
CDK5RAP3 CDK5 regulatory
3003



subunit-associated protein 3


Q96T51_C320
RUFY1 RUN and FYVE
3004



domain-containing protein 1


Q13503_C29
MED21 Mediator of RNA
3005



polymerase II transcription



subunit


P49721_C46
PSMB2 Proteasome subunit
3006



beta type-2


O75376_C2056
NCOR1 Nuclear receptor
3007



corepressor 1


Q86UP2_C1105
KTN1 Kinectin
3008


Q8TB45_C247
DEPTOR DEP domain-
3009



containing mTOR-interacting



protein


P41252_C87
IARS Isoleucine--tRNA ligase,
3010



cytoplasmic


P41252_C120
IARS Isoleucine--tRNA ligase,
3011



cytoplasmic


P41252_C433
IARS Isoleucine--tRNA ligase,
3012



cytoplasmic


Q06203_C496
PPAT
3013



Amidophosphoribosyltransferase


Q15437_C767
SEC23B Protein transport
3014



protein Sec23B


Q9NQW6_C71
ANLN Actin-binding protein
3015



anillin


Q9UBF6_C61
RNF7 RING-box protein 2
3016


P51649_C110
ALDH5A1 Succinate-
3017



semialdehyde dehydrogenase,



mitochondrial


I3L420_C80
LSM14A Protein LSM14
3018



homolog A


Q13263_C88
TRIM28 Transcription
3019



intermediary factor 1-beta


Q5VTU8_C19
ATP5EP2 ATP synthase
3020



subunit epsilon-like protein,



mitochondrial


P06733_C337
ENO1 Alpha-enolase
3021


P08559_C94
PDHA1 Pyruvate
3022



dehydrogenase E1 component



subunit alpha,


Q14166_C642
TTLL12 Tubulin--tyrosine
3023



ligase-like protein 12


Q9BW92_C506
TARS2 Threonine--tRNA
3024



ligase, mitochondrial


Q12824_C223
SMARCB1 SWI/SNF-related
3025



matrix-associated actin-



dependent


O00410_C733
IPO5 Importin-5
3026


Q9BXV9_C21
C14orf142 Uncharacterized
3027



protein C14orf142


Q53GG5_C77
PDLIM3 PDZ and LIM
3028



domain protein 3


P36776_C858
LONP1 Lon protease homolog,
3029



mitochondrial


Q16531_C652
DDB1 DNA damage-binding
3030



protein 1


Q96PZ0_C38
PUS7 Pseudouridylate
3031



synthase 7 homolog


Q9HBM6_C121
TAF9B Transcription initiation
3032



factor TFIID subunit 9B


A0AVT1_C625
UBA6 Ubiquitin-like modifier-
3033



activating enzyme 6


P53384_C31
NUBP1 Cytosolic Fe—S cluster
3034



assembly factor NUBP1


Q8TBE9_C242
NANP N-acylneuraminate-9-
3035



phosphatase


P10644_C362
PRKAR1A cAMP-dependent
3036



protein kinase type I-alpha



regulatory subunit alpha


P49790_C1065
NUP153 Nuclear pore
3037



complex protein Nup153


Q00610_C617
CLTC Clathrin heavy chain 1
3038


Q00610_C753
CLTC Clathrin heavy chain 1
3039


O00506_C357
STK25 Serine/threonine-
3040



protein kinase 25


Q6SJ93_C523
FAM111B Protein FAM111B
3041


Q01581_C86
HMGCS1
3042



Hydroxymethylglutaryl-CoA



synthase, cytoplasmic


P35658_C917
NUP214 Nuclear pore
3043



complex protein Nup214


P46013_C958
MKI67 Antigen KI-67
3044


Q14005_C975
IL16 Pro-interleukin-16
3045


P40937_C73
RFC5 Replication factor C
3046



subunit 5


Q14653_C371
IRF3 Interferon regulatory
3047



factor 3


P07900_C420
HSP90AA1 Heat shock protein
3048



HSP 90-alpha


P21333_C649
FLNA Filamin-A
3049


P21333_C1260
FLNA Filamin-A
3050


P21333_C2160
FLNA Filamin-A
3051


Q7Z3D6_C265
C14orf159 UPF0317 protein
3052



C14orf159, mitochondrial


O00264_C129
PGRMC1 Membrane-
3053



associated progesterone



receptor component 1


Q15345_C123
LRRC41 Leucine-rich repeat-
3054



containing protein 41


P43490_C397
NAMPT Nicotinamide
3055



phosphoribosyltransferase


O43504_C66
HBXIP Hepatitis B virus X-
3056



interacting protein


P48307_C130
TFPI2 Tissue factor pathway
3057



inhibitor 2


P18074_C663
ERCC2 TFHH basal
3058



transcription factor complex



helicase


Q9NV35_C23
NUDT15 Probable 8-oxo-
3059



dGTP diphosphatase NUDT15


Q12888_C896
TP53BP1 Tumor suppressor
3060



p53-binding protein 1


Q8TAC2_C168
JOSD2 Josephin-2
3061


Q6P1L8_C90
MRPL14 39S ribosomal
3062



protein L14, mitochondrial


Q92576_C441
PHF3 PHD finger protein 3
3063


P63000_C105
RAC1 Ras-related C3
3064



botulinum toxin substrate 1


O94776_C261
MTA2 Metastasis-associated
3065



protein MTA2


Q9P0K7_C131
RAI14 Ankycorbin
3066


Q92747_C162
ARPC1A Actin-related protein
3067



2/3 complex subunit 1A


Q8NE71_C741
ABCF1 ATP-binding cassette
3068



sub-family F member 1


P58546_C45
MTPN Myotrophin
3069


Q10570_C1044
CPSF1 Cleavage and
3070



polyadenylation specificity



factor subunit 1


Q15021_C320
NCAPD2 Condensin complex
3071



subunit 1


Q6P1N0_C252
CC2D1A Coiled-coil and C2
3072



domain-containing protein 1A


O43818_C399
RRP9 U3 small nucleolar
3073



RNA-interacting protein 2


Q92556_C726
ELMO1 Engulfment and cell
3074



motility protein 1


Q9NSP4_C110
CENPM Centromere protein
3075



M


P22234_C151
PAICS Multifunctional protein
3076



ADE2


Q96RN5_C698
MED15 Mediator of RNA
3077



polymerase II transcription



subunit


Q8IWZ3_C181
ANKHD1 Ankyrin repeat and
3078



KH domain-containing protein



1


H3BN98_C109
Uncharacterized protein
3079


Q14683_C1115
SMC1A Structural
3080



maintenance of chromosomes



protein 1A


P33764_C99
S100A3 Protein S100-A3
3081


Q8NF50_C143
DOCK8 Dedicator of
3082



cytokinesis protein 8


Q9NZT2_C87
OGFR Opioid growth factor
3083



receptor


Q13620_C248
CUL4B Cullin-4B
3084


P00505_C187
GOT2 Aspartate
3085



aminotransferase,



mitochondrial


Q9Y262_C417
EIF3L Eukaryotic translation
3086



initiation factor 3 subunit


O75521_C282
ECI2 Enoyl-CoA delta
3087



isomerase 2, mitochondrial


Q01469_C120
FABP5 Fatty acid-binding
3088



protein, epidermal


O14965_C33
AURKA Aurora kinase A
3089


P24844_C109
MYL9 Myosin regulatory light
3090



polypeptide 9


Q9ULT8_C2415
HECTD1 E3 ubiquitin-protein
3091



ligase HECTD1


P81877_C82
SSBP2 Single-stranded DNA-
3092



binding protein 2


Q9UJX3_C329
ANAPC7 Anaphase-promoting
3093



complex subunit 7


Q9BW19_C663
KIFC1 Kinesin-like protein
3094



KIFC1


P51553_C333
IDH3G Isocitrate
3095



dehydrogenase


P32320_C53
CDA Cytidine deaminase
3096


Q02750_C376
MAP2K1 Dual specificity
3097



mitogen-activated protein



kinase


O94829_C163
IPO13 Importin-13
3098


Q9UNH7_C149
SNX6 Sorting nexin-6
3099


Q9UQ80_C149
PA2G4 Proliferation-
3100



associated protein 2G4


P13674_C503
P4HA1 Prolyl 4-hydroxylase
3101



subunit alpha-1


O95239_C153
KIF4A Chromosome-
3102



associated kinesin KIF4A


P08134_C20
RHOC Rho-related GTP-
3103



binding protein RhoC


P15121_C45
AKR1B1 Aldose reductase
3104


P42704_C208
LRPPRC Leucine-rich PPR
3105



motif-containing protein,



mitochondrial


Q9BYV9_C370
BACH2 Transcription
3106



regulator protein BACH2



SPACPFDK



R.SPAC*PFDK.G


Q9P0V9_C22
SEPT10 Septin-10
3107


P51570_C203
GALK1 Galactokinase
3108


Q7Z5L9_C37
IRF2BP2 Interferon regulatory
3109



factor 2-binding protein 2


Q86VP6_C1007
CAND1 Cullin-associated
3110



NEDD8-dissociated protein 1


Q6KB66_C244
KRT80 Keratin, type II
3111



cytoskeletal 80


P17980_C240
PSMC3 26S protease
3112



regulatory subunit 6A


P13797_C566
PLS3 Plastin-3
3113


Q15599_C271
SLC9A3R2 Na(+)/H(+)
3114



exchange regulatory cofactor



NHE-RF2


P41134_C45
ID1 DNA-binding protein
3115



inhibitor ID-1


Q06210_C264
GFPT1 Glucosamine--
3116



fructose-6-phosphate



aminotransferase


P12694_C178
BCKDHA 2-oxoisovalerate
3117



dehydrogenase subunit alpha,



mitochondrial


Q5XKP0_C60
QIL1 Protein QIL1
3118


Q9UMS4_C298
PRPF19 Pre-mRNA-
3119



processing factor 19


Q9H2U2_C44
PPA2 Inorganic
3120



pyrophosphatase 2,



mitochondrial


Q9H2U2_C283
PPA2 Inorganic
3121



pyrophosphatase 2,



mitochondrial


Q68CZ2_C615
TNS3 Tensin-3
3122


Q99933_C272
BAG1 BAG family molecular
3123



chaperone regulator 1


Q86U42_C205
PABPN1 Polyadenylate-
3124



binding protein 2


Q14141_C42
SEPT6 Septin-6
3125


Q9H4B0_C390
OSGEPL1 Probable tRNA
3126



threonylcarbamoyladenosine



biosynthesis protein OSGEPL1


P13796_C140
LCP1 Plastin-2
3127


Q06330_C397
RBPJ Recombining binding
3128



protein suppressor of hairless


Q6NVY1_C45
HIBCH 3-hydroxyisobutyryl-
3129



CoA hydrolase, mitochondrial


Q9BYB4_C175
GNB1L Guanine nucleotide-
3130



binding protein subunit beta-



like protein 1


P43681_C225
CHRNA4 Neuronal
3131



acetylcholine receptor subunit



alpha-4


Q9Y490_C2408
TLN1 Talin-1
3132


P39748_C163
FEN1 Flap endonuclease 1
3133


P49137_C224
MAPKAPK2 MAP kinase-
3134



activated protein kinase 2


O96013_C276
PAK4 Serine/threonine-protein
3135



kinase PAK 4


P49748_C477
ACADVL Very long-chain
3136



specific acyl-CoA



dehydrogenase, m


Q7Z4W1_C244
DCXR Lxylulose reductase
3137


P33992_C355
MCM5 DNA replication
3138



licensing factor MCM5


A6NHR9_C59
SMCHD1 Structural
3139



maintenance of chromosomes



flexible hinge domain



containing 1


O15460_C529
P4HA2 Prolyl 4-hydroxylase
3140



subunit alpha-2


Q12824_C350
SMARCB1 SWI/SNF-related
3141



matrix-associated actin-



dependent


O00410_C944
IPOS Importin-5
3142


Q96CP2_C64
FLYWCH2 FLYWCH family
3143



member 2


Q15080_C84
NCF4 Neutrophil cytosol
3144



factor 4


Q02241_C483
KIF23 Kinesin-like protein
3145



KIF23


Q9NSV4_C102
DIAPH3 Protein diaphanous
3146



homolog 3


Q96N67_C1944
DOCK7 Dedicator of
3147



cytokinesis protein 7


P16885_C1200
PLCG2 1-phosphatidylinositol
3148



4,5-bisphosphate



phosphodiesterase gamma-2


Q15366_C301
PCBP2 Poly(rC)-binding
3149



protein 2


Q92598_C290
HSPH1 Heat shock protein 105
3150



kDa


P53384_C277
NUBP1 Cytosolic Fe—S cluster
3151



assembly factor NUBP1


Q15181_C254
PPA1 Inorganic
3152



pyrophosphatase


Q7Z5K2_C344
WAPAL Wings apart-like
3153



protein homolog


Q7Z5K2_C906
WAPAL Wings apart-like
3154



protein homolog


Q8NFC6_C285
BOD1L1 Biorientation of
3155



chromosomes in cell division



protein


P53634_C258
CTSC Dipeptidyl peptidase 1
3156


Q96G25_C31
MED8 Mediator of RNA
3157



polymerase II transcription



subunit


P10644_C39
PRKAR1A cAMP-dependent
3158



protein kinase type I-alpha



regulat


O00273_C38
DFFA DNA fragmentation
3159



factor subunit alpha


P49792_C2577
RANBP2 E3 SUMO-protein
3160



ligase RanBP2


P49792_C2791
RANBP2 E3 SUMO-protein
3161



ligase RanBP2


Q93009_C961
USP7 Ubiquitin carboxyl-
3162



terminal hydrolase 7


Q00610_C491
CLTC Clathrin heavy chain 1
3163


O60547_C92
GMDS GDP-mannose 4,6
3164



dehydratase


Q9H0P0_C73
NT5C3 Cytosolic 5-
3165



nucleotidase 3


O75427_C105
LRCH4 Leucine-rich repeat
3166



and calponin homology



domain-containing 4


Q4G0N4_C58
NADKD1 NAD kinase
3167



domain-containing protein 1


Q9Y4P8_C393
WIPI2 WD repeat domain
3168



phosphoinositide-interacting



protein


P27695_C65
APEX1 DNA-(apurinic or
3169



apyrimidinic site) lyase


Q15004_C99
KIAA0101 PCNA-associated
3170



factor


P17858_C114
PFKL 6-phosphofructokinase,
3171



liver type


P17858_C334
PFKL 6-phosphofructokinase,
3172



liver type


Q96PK6_C90
RBM14 RNA-binding protein
3173



14


Q09028_C167
RBBP4 Histone-binding
3174



protein RBBP4


Q8TC07_C24
TBC1D15 TBC1 domain
3175



family member 15


Q7Z6Z7_C2721
HUWE1 E3 ubiquitin-protein
3176



ligase HUWE1


Q9H6S3_C369
EPS8L2 Epidermal growth
3177



factor receptor kinase substrate


Q9Y281_C80
CFL2 Cofilin-2
3178


Q96IZ6_C171
METTL2A Methyltransferase-
3179



like protein 2A


Q96EM0_C39
L3HYPDH Trans-L-3-
3180



hydroxyproline dehydratase


Q92616_C2255
GCN1L1 Translational
3181



activator GCN1


P43490_C401
NAMPT Nicotinamide
3182



phosphoribosyltransferase


P22087_C268
FBL rRNA 2-O-
3183



methyltransferase fibrillarin


Q92503_C644
SEC14L1 SEc14-like protein
3184



1


Q9UI10_C69
EIF2B4 Translation initiation
3185



factor eIF-2B subunit delta


P49327_C161
FASN Fatty acid synthase
3186


P49327_C1141
FASN Fatty acid synthase
3187


P49327_C1227
FASN Fatty acid synthase
3188


Q9ULZ3_C173
PYCARD Apoptosis-
3189



associated speck-like protein



containing


Q8WUI4_C904
HDAC7 Histone deacetylase 7
3190


Q7L2J0_C324
MEPCE 7SK snRNA
3191



methylphosphate capping



enzyme


Q9BUK6_C46
MSTO1 Protein misato
3192



homolog 1


P54577_C424
YARS Tyrosine--tRNA ligase,
3193



cytoplasmic


Q8WU90_C105
ZC3H15 Zinc finger CCCH
3194



domain-containing protein 15


Q9Y305_C194
ACOT9 Acyl-coenzyme A
3195



thioesterase 9, mitochondrial


Q15149_C1098
PLEC Plectin
3196


Q14669_C535
TRIP12 E3 ubiquitin-protein
3197



ligase TRIP12


Q9BTT0_C123
ANP32E Acidic leucine-rich
3198



nuclear phosphoprotein 32



family member E


Q92989_C338
CLP1 Polyribonucleotide 5-
3199



hydroxyl-kinase Clp1


P06132_C59
UROD Uroporphyrinogen
3200



decarboxylase


Q96EY7_C139
PTCD3 Pentatricopeptide
3201



repeat-containing protein 3,



mitochondrial


P78527_C90
PRKDC DNA-dependent
3202



protein kinase catalytic subunit


P78527_C1312
PRKDC DNA-dependent
3203



protein kinase catalytic subunit


P78527_C1767
PRKDC DNA-dependent
3204



protein kinase catalytic subunit


Q92747_C279
ARPC1A Actin-related protein
3205



2/3 complex subunit 1A


Q14671_C234
PUM1 Pumilio homolog 1
3206


O60216_C585
RAD21 Double-strand-break
3207



repair protein rad21 homolog


Q5VZF2_C19
MBNL2 Muscleblind-like
3208



protein 2


Q9UEW8_C525
STK39 STE20/SPS1-related
3209



proline-alanine-rich protein



kinase


O00232_C255
PSMD12 26S proteasome non-
3210



ATPase regulatory subunit 12


O00233_C81
PSMD9 26S proteasome non-
3211



ATPase regulatory subunit 9


Q5GLZ8_C392
HERC4 Probable E3 ubiquitin-
3212



protein ligase HERC4


O14579_C212
COPE Coatomer subunit
3213



epsilon


Q7Z4G1_C35
COMMD6 COMM domain-
3214



containing protein 6


P17812_C218
CTPS1 CTP synthase 1
3215


O95394_C200
PGM3
3216



Phosphoacetylglucosamine



mutase


Q7LBC6_C1357
KDM3B Lysine-specific
3217



demethylase 3B


Q99496_C72
RNF2 E3 ubiquitin-protein
3218



ligase RING2


Q9UNW1_C232
MINPP1 Multiple inositol
3219



polyphosphate phosphatase 1


P50453_C259
SERPINB9 Serpin B9
3220


Q9NZT2_C417
OGFR Opioid growth factor
3221



receptor


O95573_C450
ACSL3 Long-chain-fatty-acid--
3222



CoA ligase 3


O60841_C720
EIF5B Eukaryotic translation
3223



initiation factor 5B


P29317_C612
EPHA2 Ephrin type-A
3224



receptor 2


O14561_C140
NDUFAB1 Acyl carrier
3225



protein, mitochondrial


Q9NXH9_C639
TRMT1 tRNA (guanine(26)-
3226



N(2))-dimethyltransferase


Q9H6Y2_C306
WDR55 WD repeat-containing
3227



protein 55


A0JLT2_C163
MED19 Mediator of RNA
3228



polymerase II transcription



subunit


Q10567_C565
AP1B1 AP-1 complex subunit
3229



beta-1


P08243_C115
ASNS Asparagine synthetase
3230


P08243_C158
ASNS Asparagine synthetase
3231


P46736_C273
BRCC3 Lys-63-specific
3232



deubiquitinase BRCC36


Q01469_C67
FABP5 Fatty acid-binding
3233



protein, epidermal


O43175_C116
PHGDH D-3-
3234



phosphoglycerate



dehydrogenase


O14818_C91
PSMA7 Proteasome subunit
3235



alpha type-7


Q9BRA2_C110
TXNDC17 Thioredoxin
3236



domain-containing protein 17


P01892_C363
HLA-A HLA class I histocompatibility
3237



antigen, A-2 alpha


P84085_C159
ARF5 ADP-ribosylation factor
3238



5


P62879_C204
GNB2 Guanine nucleotide-
3239



binding protein G(I)/G(S)/G(T)


Q9C0C9_C244
UBE2O Ubiquitin-conjugating
3240



enzyme E2 O


Q9C0C9_C598
UBE2O Ubiquitin-conjugating
3241



enzyme E2 O


Q14204_C3573
DYNC1H1 Cytoplasmic
3242



dynein 1 heavy chain 1


O60684_C238
KPNA6 Importin subunit
3243



alpha-7


P20073_C413
ANXA7 Annexin A7
3244


O75643_C1127
SNRNP200 U5 small nuclear
3245



ribonucleoprotein 200 kDa



helicase


P32320_C31
CDA Cytidine deaminase
3246


P11586_C236
MTHFD1 C-1-tetrahydrofolate
3247



synthase, cytoplasmic


H3BN57_C113
BLOC1S5-TXNDC5 Protein
3248



BLOC1S5-TXNDC5


Q53HC9_C95
TSSC1 Protein TSSC1
3249


P27816_C67
MAP4 Microtubule-associated
3250



protein 4


P84090_C33
ERH Enhancer of rudimentary
3251



homolog


O00487_C299
PSMD14 26S proteasome non-
3252



ATPase regulatory subunit 14


Q8N8R5_C43
C2orf69 UPF0565 protein
3253



C2orf69


P52948_C1027
NUP98 Nuclear pore complex
3254



protein Nup98-Nup96


P52948_C1068
NUP98 Nuclear pore complex
3255



protein Nup98-Nup96


Q4G0P3_C1853
HYDIN Hydrocephalus-
3256



inducing protein homolog


Q08J23_C502
NSUN2 tRNA (cytosine(34)-
3257



C(5))-methyltransferase


O15231_C542
ZNF185 Zinc finger protein
3258



185


P21291_C122
CSRP1 Cysteine and glycine-
3259



rich protein 1


O43447_C122
PPIH Peptidyl-prolyl cis-trans
3260



isomerase H


P08237_C170
PFKM 6-phosphofructokinase,
3261



muscle type


Q1KMD3_C602
HNRNPUL2 Heterogeneous
3262



nuclear ribonucleoprotein U-



like protein 2


P51991_C94
HNRNPA3 Heterogeneous
3263



nuclear ribonucleoprotein A3


P35237_C36
SERPINB6 Serpin B6
3264


Q96FJ2_C24
DYNLL2 Dynein light chain 2,
3265



cytoplasmic


Q9BTZ2_C209
DHRS4
3266



Dehydrogenase/reductase SDR



family member 4


Q9UMS4_C230
PRPF19 Pre-mRNA-
3267



processing factor 19


Q9Y6A5_C459
TACC3 Transforming acidic
3268



coiled-coil-containing protein


Q86TI0_C604
TBC1D1 TBC1 domain family
3269



member 1


Q9H0W9_C226
C11orf54 Ester hydrolase
3270



C11orf54


P18031_C121
PTPN1 Tyrosine-protein
3271



phosphatase non-receptor type



1


O60343_C1286
TBC1D4 TBC1 domain family
3272



member 4


O60759_C210
CYTIP Cytohesin-interacting
3273



protein


P10398_C192
ARAF Serine/threonine-
3274



protein kinase A-Raf


Q71SY5_C111
MED25 Mediator of RNA
3275



polymerase II transcription



subunit


Q9Y490_C1392
TLN1 Talin-1
3276


P43246_C873
MSH2 DNA mismatch repair
3277



protein Msh2


P23381_C305
WARS Tryptophan--tRNA
3278



ligase, cytoplasmic


Q9NXV2_C28
KCTD5 BTB/POZ domain-
3279



containing protein KCTD5


P21399_C369
ACO1 Cytoplasmic aconitate
3280



hydratase


Q06830_C52
PRDX1 Peroxiredoxin-1
3281


Q96D46_C20
NMD3 60S ribosomal export
3282



protein NMD3


Q9Y6C9_C79
MTCH2 Mitochondrial carrier
3283



homolog 2


O00429_C446
DNM1L Dynamin-1-like
3284



protein


P50552_C64
VASP Vasodilator-stimulated
3285



phosphoprotein


Q00796_C120
SORD Sorbitol dehydrogenase
3286


P42126_C114
ECI1 Enoyl-CoA delta
3287



isomerase 1, mitochondrial


P49368_C213
CCT3 T-complex protein 1
3288



subunit gamma


Q9NY27_C105
PPP4R2 Serine/threonine-
3289



protein phosphatase 4



regulatory


P49756_C83
RBM25 RNA-binding protein
3290



25


F5H5P2_C231
Uncharacterized protein
3291


Q14C86_C741
GAPVD1 GTPase-activating
3292



protein and VPS9 domain-



containing protein 1


Q969V6_C326
MKL1 MKL/myocardin-like
3293



protein 1


Q9P2N5_C21
RBM27 RNA-binding protein
3294



27


P53396_C229
ACLY ATP-citrate synthase
3295


Q8WVT3_C160
TRAPPC12 Trafficking
3296



protein particle complex



subunit 12


O43678_C24
NDUFA2 NADH
3297



dehydrogenase


Q96IF1_C270
AJUBA LIM domain-
3298



containing protein ajuba


Q14974_C158
KPNB1 Importin subunit beta-
3299



1


P21266_C178
GSTM3 Glutathione S-
3300



transferase Mu 3


O00622_C322
CYR61 Protein CYR61
3301


Q96N67_C193
DOCK7 Dedicator of
3302



cytokinesis protein 7


Q15369_C74
TCEB1 Transcription
3303



elongation factor B



polypeptide 1


A6NDU8_C57
C5orf51 UPF0600 protein
3304



C5orf51


Q9P219_C1871
CCDC88C Protein Daple
3305


Q09161_C73
NCBP1 Nuclear cap-binding
3306



protein subunit 1


Q69YN2_C141
CWF19L1 CWF19-like protein
3307



1


Q70E73_C1045
RAPH1 Ras-associated and
3308



pleckstrin homology domains-



containing protein 1


Q93008_C1237
USP9X Probable ubiquitin
3309



carboxyl-terminal hydrolase



FAF


Q9UQ13_C144
SHOC2 Leucine-rich repeat
3310



protein SHOC-2


Q9BXP5_C715
SRRT Serrate RNA effector
3311



molecule homolog


Q96P65_C201
QRFPR Pyroglutamylated
3312



RFamide peptide receptor


P46013_C261
MKI67 Antigen KI-67
3313


P17858_C630
PFKL 6-phosphofructokinase,
3314



liver type


O75083_C285
WDR1 WD repeat-containing
3315



protein 1


O43252_C78
PAPSS1 Bifunctional 3-
3316



phosphoadenosine 5-



phosphosulfate


Q6WCQ1_C724
MPRIP Myosin phosphatase
3317



Rho-interacting protein


Q14008_C1360
CKAP5 Cytoskeleton-
3318



associated protein 5


P40939_C349
HADHA Trifunctional enzyme
3319



subunit alpha, mitochondrial


P21333_C2293
FLNA Filamin-A
3320


P30566_C483
ADSL Adenylosuccinate lyase
3321


Q9Y285_C493
FARSA Phenylalanine--tRNA
3322



ligase alpha subunit


Q06124_C318
PTPN11 Tyrosine-protein
3323



phosphatase non-receptor type



11


Q96SZ5_C18
ADO 2-aminoethanethiol
3324



dioxygenase


Q96CM8_C122
ACSF2 Acyl-CoA synthetase
3325



family member 2,



mitochondrial


P46063_C606
RECQL ATP-dependent DNA
3326



helicase Q1


P53618_C248
COPB1 Coatomer subunit beta
3327


P53618_C684
COPB1 Coatomer subunit beta
3328


Q9UI10_C465
EIF2B4 Translation initiation
3329



factor eIF-2B subunit delta


Q9UI10_C509
EIF2B4 Translation initiation
3330



factor eIF-2B subunit delta


Q8WV28_C271
BLNK B-cell linker protein
3331


P49327_C2273
FASN Fatty acid synthase
3332


Q9UGV2_C359
NDRG3 Protein NDRG3
3333


Q99436_C87
PSMB7 Proteasome subunit
3334



beta type-7


Q86YS7_C867
KIAA0528 Uncharacterized
3335



protein KIAA0528


P48444_C286
ARCN1 Coatomer subunit
3336



delta


Q86V48_C560
LUZP1 Leucine zipper protein
3337



1


Q9UQ35_C1029
SRRM2 Serine/arginine
3338



repetitive matrix protein 2


Q9BSH5_C109
HDHD3 Haloacid
3339



dehalogenase-like hydrolase



domain-containing 3


Q92973_C790
TNPO1 Transportin-1
3340


Q8N3F8_C597
MICALL1 MICAL-like
3341



protein 1


O95425_C1949
SVIL Supervillin
3342


Q8IVH2_C447
FOXP4 Forkhead box protein
3343



P4


Q15149_C965
PLEC Plectin
3344


P25788_C42
PSMA3 Proteasome subunit
3345



alpha type-3


Q9HB40_C152
SCPEP1 Retinoid-inducible
3346



serine carboxypeptidase


Q08945_C139
SSRP1 FACT complex subunit
3347



SSRP1


Q00577_C272
PURA Transcriptional
3348



activator protein Pur-alpha


Q96EY5_C33
FAM125A Multivesicular
3349



body subunit 12A


P13639_C536
EEF2 Elongation factor 2
3350


P28799_C178
GRN Granulins
3351


Q14258_C475
TRIM25 E3 ubiquitin/ISG15
3352



ligase TRIM25


O75694_C874
NUP155 Nuclear pore
3353



complex protein Nup155


P49189_C267
ALDH9A1 4-
3354



trimethylaminobutyraldehyde



dehydrogenase


O43592_C522
XPOT Exportin-T
3355


Q9NUQ3_C127
TXLNG Gamma-taxilin
3356


O94760_C178
DDAH1 N(G),N(G)-
3357



dimethylarginine



dimethylaminohydrolase


P61163_C222
ACTR1A Alpha-centractin
3358


Q12905_C311
ILF2 Interleukin enhancer-
3359



binding factor 2


Q14814_C217
MEF2D Myocyte-specific
3360



enhancer factor 2D


P50990_C430
CCT8 T-complex protein 1
3361



subunit theta


P49848_C644
TAF6 Transcription initiation
3362



factor TFIID subunit 6


O00541_C153
PES1 Pescadillo homolog
3363


P17812_C30
CTPS1 CTP synthase 1
3364


Q9P287_C213
BCCIP BRCA2 and
3365



CDKN1A-interacting protein


Q7LBC6_C1212
KDM3B Lysine-specific
3366



demethylase 3B


Q9Y3P9_C155
RABGAP1 Rab GTPase-
3367



activating protein 1


Q99497_C53
PARK7 Protein DJ-1
3368


O95571_C98
ETHE1 Protein ETHE1,
3369



mitochondrial


Q8WUM0_C530
NUP133 Nuclear pore
3370



complex protein Nup133


P11387_C630
TOP1 DNA topoisomerase 1
3371


P25098_C340
ADRBK1 Beta-adrenergic
3372



receptor kinase 1


Q15796_C70
SMAD2 Mothers against
3373



decapentaplegic homolog 2


Q8NF50_C170
DOCK8 Dedicator of
3374



cytokinesis protein 8


Q8NF50_C186
DOCK8 Dedicator of
3375



cytokinesis protein 8


Q8N5N7_C52
MRPL50 39S ribosomal
3376



protein L50, mitochondrial


Q86UW9_C351
DTX2 Probable E3 ubiquitin-
3377



protein ligase DTX2


I3L3Q1_C657
Uncharacterized protein
3378


Q96QA5_C174
GSDMA Gasdermin-A
3379


Q9Y263_C605
PLAA Phospholipase A-2-
3380



activating protein


O75521_C312
ECI2 Enoyl-CoA delta
3381



isomerase 2, mitochondrial


P08243_C44
ASNS Asparagine synthetase
3382


Q9BQS8_C293
FYCO1 FYVE and coiled-coil
3383



domain-containing protein 1


Q96QK1_C699
VPS35 Vacuolar protein
3384



sorting-associated protein 35


Q8NDI1_C849
EHBP1 EH domain-binding
3385



protein 1


P19367_C158
HK1 Hexokinase-1
3386


O14818_C63
PSMA7 Proteasome subunit
3387



alpha type-7


Q13439_C1085
GOLGA4 Golgin subfamily A
3388



member 4


P63279_C93
UBE2I SUMO-conjugating
3389



enzyme UBC9


Q15003_C114
NCAPH Condensin complex
3390



subunit 2


O75534_C730
CSDE1 Cold shock domain-
3391



containing protein E1


Q8WVB6_C373
CHTF18 Chromosome
3392



transmission fidelity protein 18



homolog


Q14204_C3033
DYNC1H1 Cytoplasmic
3393



dynein 1 heavy chain 1


Q9UN37_C233
VPS4A Vacuolar protein
3394



sorting-associated protein 4A


Q8WV99_C171
ZFAND2B AN1-type zinc
3395



finger protein 2B


P22102_C237
GART Trifunctional purine
3396



biosynthetic protein adenosine


O75643_C133
SNRNP200 U5 small nuclear
3397



ribonucleoprotein 200 kDa



helicase


P32322_C95
PYCR1 Pyrroline-5-
3398



carboxylate reductase 1,



mitochondrial


Q9H1K1_C138
ISCU Iron-sulfur cluster
3399



assembly enzyme ISCU,



mitochondrial


Q6IA69_C428
NADSYN1 Glutamine-
3400



dependent NAD(+) synthetase


Q9UQ80_C296
PA2G4 Proliferation-
3401



associated protein 2G4


Q9NP81_C64
SARS2 Serine--tRNA ligase,
3402



mitochondrial


Q6L8Q7_C180
PDE12 2,5-phosphodiesterase
3403



12


Q15102_C205
PAFAH1B3 Platelet-activating
3404



factor acetylhydrolase IB



subunit


Q9Y448_C296
SKAP Small kinetochore-
3405



associated protein


Q01082_C1389
SPTBN1 Spectrin beta chain,
3406



non-erythrocytic 1


P42704_C113
LRPPRC Leucine-rich PPR
3407



motif-containing protein,



mitochondrial


O60784_C415
TOM1 Target of Myb protein
3408



1


P42858_C1998
HTT Huntingtin
3409


A2A288_C517
ZC3H12D Probable
3410



ribonuclease ZC3H12D


P31930_C453
UQCRC1 Cytochrome b-c1
3411



complex subunit 1,



mitochondrial


P31939_C287
ATIC Bifunctional purine
3412



biosynthesis protein PURH


Q14980_C2009
NUMA1 Nuclear mitotic
3413



apparatus protein 1


Q9NSE4_C364
IARS2 Isoleucine--tRNA
3414



ligase, mitochondrial


Q9NSE4_C521
IARS2 Isoleucine--tRNA
3415



ligase, mitochondrial


Q96ER3_C248
SAAL1 Protein SAAL1
3416


Q5M775_C493
SPECC1 Cytospin-B
3417


Q9P2J5_C446
LARS Leucine--tRNA ligase,
3418



cytoplasmic


P35236_C204
PTPN7 Tyrosine-protein
3419



phosphatase non-receptor type



7


P14324_C204
FDPS Farnesyl pyrophosphate
3420



synthase


P53597_C142
SUCLG1 Succinyl-CoA ligase
3421


Q9GZT3_C48
SLIRP SRA stem-loop-
3422



interacting RNA-binding



protein, mitochondrial


P10619_C403
CTSA Lysosomal protective
3423



protein


Q9UDY2_C601
TJP2 Tight junction protein
3424



ZO-2


Q13501_C290
SQSTM1 Sequestosome-1
3425


Q53EL6_C150
PDCD4 Programmed cell
3426



death protein 4


Q13618_C636
CUL3 Cullin-3
3427


Q93052_C465
LPP Lipoma-preferred partner
3428


Q92900_C683
UPF1 Regulator of nonsense
3429



transcripts 1


Q9Y5P6_C230
GMPPB Mannose-1-phosphate
3430



guanyltransferase beta


O14981_C936
BTAF1 TATA-binding
3431



protein-associated factor 172


Q9NR31_C102
SAR1A GTP-binding protein
3432



SAR1a


Q92623_C30
TTC9 Tetratricopeptide repeat
3433



protein 9A


P41743_C595
PRKCI Protein kinase C iota
3434



type


Q6NVY1_C163
HIBCH 3-hydroxyisobutyryl-
3435



CoA hydrolase, mitochondrial


Q29RF7_C14
PDS5A Sister chromatid
3436



cohesion protein PDS5



homolog A


Q9NQW6_C819
ANLN Actin-binding protein
3437



anillin


Q9Y490_C1434
TLN1 Talin-1
3438


Q86W50_C432
METTL16 Methyltransferase-
3439



like protein 16


Q8IV48_C75
ERI1 3-5 exoribonuclease 1
3440


Q9Y3Z3_C341
SAMHD1 SAM domain and
3441



HD domain-containing protein



1


P38646_C366
HSPA9 Stress-70 protein,
3442



mitochondrial


P47755_C111
CAPZA2 F-actin-capping
3443



protein subunit alpha-2


P06730_C170
EIF4E Eukaryotic translation
3444



initiation factor 4E


Q9NR09_C1517
BIRC6 Baculoviral IAP
3445



repeat-containing protein 6


P00491_C78
PNP Purine nucleoside
3446



phosphorylase


P08397_C261
HMBS Porphobilinogen
3447



deaminase


Q7KZF4_C736
SND1 Staphylococcal nuclease
3448



domain-containing protein


O60292_C235
SIPA1L3 Signal-induced
3449



proliferation-associated 1-like



protein 3


Q14166_C528
TTLL12 Tubulin--tyrosine
3450



ligase-like protein 12


Q14166_C572
TTLL12 Tubulin--tyrosine
3451



ligase-like protein 12


Q13257_C106
MAD2L1 Mitotic spindle
3452



assembly checkpoint protein



MAD2A


Q9NY27_C134
PPP4R2 Serine/threonine-
3453



protein phosphatase 4



regulatory


P30405_C104
PPIF Peptidyl-prolyl cis-trans
3454



isomerase F, mitochondrial


Q9H0D6_C296
XRN2 5-3 exoribonuclease 2
3455


Q8TDG2_C182
ACTRT1 Actin-related protein
3456



T1


O00410_C473
IPO5 Importin-5
3457


Q5VUA4_C2168
ZNF318 Zinc finger protein
3458



318


Q8IXB1_C700
DNAJC10 DnaJ homolog
3459



subfamily C member 10


P53621_C975
COPA Coatomer subunit alpha
3460


P00441_C147
SOD1 Superoxide dismutase
3461


Q00534_C306
CDK6 Cyclin-dependent
3462



kinase 6


P02545_C570
LMNA Prelamin-A/C
3463


P16885_C791
PLCG2 1-phosphatidylinositol
3464



4,5-bisphosphate



phosphodiesterase gamma-2


A0AVT1_C546
UBA6 Ubiquitin-like modifier-
3465



activating enzyme 6


Q15369_C11
TCEB1 Transcription
3466



elongation factor B



polypeptide 1


Q9BVL2_C252
NUPL1 Nucleoporin p58/p45
3467


O15091_C367
KIAA0391 Mitochondrial
3468



ribonuclease P protein 3


Q92835_C902
INPP5D Phosphatidylinositol
3469



3,4,5-trisphosphate 5-



phosphatase 1


Q92835_C1088
INPP5D Phosphatidylinositol
3470



3,4,5-trisphosphate 5-



phosphatase 1


Q9H3M7_C36
TXNIP Thioredoxin-
3471



interacting protein


Q9H3M7_C333
TXNIP Thioredoxin-
3472



interacting protein


Q92598_C845
HSPH1 Heat shock protein 105
3473



kDa


Q8NEM2_C612
SHCBP1 SHC SH2 domain-
3474



binding protein 1


Q92619_C324
HMHA1 Minor
3475



histocompatibility protein HA-



1


O94906_C913
PRPF6 Pre-mRNA-processing
3476



factor 6


Q5TA50_C163
GLTPD1 Glycolipid transfer
3477



protein domain-containing



protein 1


Q9UPN7_C172
PPP6R1 Serine/threonine-
3478



protein phosphatase 6



regulatory


Q9P289_C392
MST4 Serine/threonine-protein
3479



kinase MST4


Q16270_C87
IGFBP7 Insulin-like growth
3480



factor-binding protein 7


P48556_C112
PSMD8 26S proteasome non-
3481



ATPase regulatory subunit 8


P49792_C1196
RANBP2 E3 SUMO-protein
3482



ligase RanBP2


P49792_C2407
RANBP2 E3 SUMO-protein
3483



ligase RanBP2


Q93008_C1212
USP9X Probable ubiquitin
3484



carboxyl-terminal hydrolase



FAF


Q9Y617_C98
PSAT1 Phosphoserine
3485



aminotransferase


Q9Y617_C152
PSAT1 Phosphoserine
3486



aminotransferase


Q96AB3_C84
ISOC2 Isochorismatase
3487



domain-containing protein 2,



mitochondrial


Q9H7Z6_C416
KAT8 Histone
3488



acetyltransferase KAT8


Q01581_C224
HMGCS1
3489



Hydroxymethylglutaryl-CoA



synthase, cytoplasmic


P62633_C57
CNBP Cellular nucleic acid-
3490



binding protein


P39023_C114
RPL3 60S ribosomal protein
3491



L3


P21333_C210
FLNA Filamin-A
3492


P21333_C1353
FLNA Filamin-A
3493


O95347_C585
SMC2 Structural maintenance
3494



of chromosomes protein 2


O00469_C562
PLOD2 Procollagen-lysine,2-
3495



oxoglutarate 5-dioxygenase 2


P45880_C13
VDAC2 Voltage-dependent
3496



anion-selective channel protein


Q96CM8_C462
ACSF2 Acyl-CoA synthetase
3497



family member 2,



mitochondrial


P18583_C92
SON Protein SON
3498


Q9UKX7_C165
NUP50 Nuclear pore complex
3499



protein Nup50


Q9UKX7_C416
NUP50 Nuclear pore complex
3500



protein Nup50


Q99661_C287
KIF2C Kinesin-like protein
3501



KIF2C


P42765_C179
ACAA2 3-ketoacyl-CoA
3502



thiolase, mitochondrial


P49327_C779
FASN Fatty acid synthase
3503


P49327_C1828
FASN Fatty acid synthase
3504


O75347_C67
TBCA Tubulin-specific
3505



chaperone A


P63010_C95
AP2B1 AP-2 complex subunit
3506



beta


Q9UDR5_C87
AASS Alpha-aminoadipic
3507



semialdehyde synthase,



mitochondrial


P40925_C154
MDH1 Malate dehydrogenase,
3508



cytoplasmic


Q13363_C38
CTBP1 C-terminal-binding
3509



protein 1


P41091_C311
EIF2S3 Eukaryotic translation
3510



initiation factor 2 subunit


Q9UKI8_C81
TLK1 Serine/threonine-protein
3511



kinase tousled-like 1


Q13523_C962
PRPF4B Serine/threonine-
3512



protein kinase PRP4 homolog


Q12768_C385
KIAA0196 WASH complex
3513



subunit strumpellin


Q14203_C636
DCTN1 Dynactin subunit 1
3514


Q96RS6_C111
NUDCD1 NudC domain-
3515



containing protein 1


Q7L2J0_C153
MEPCE 7SK snRNA
3516



methylphosphate capping



enzyme


Q8N0Z6_C439
TTC5 Tetratricopeptide repeat
3517



protein 5


P13716_C223
ALAD Delta-aminolevulinic
3518



acid dehydratase


P12270_C1127
TPR Nucleoprotein TPR
3519


Q92973_C205
TNPO1 Transportin-1
3520


P24928_C981
POLR2A DNA-directed RNA
3521



polymerase II subunit RPB1


P52597_C22
HNRNPF Heterogeneous
3522



nuclear ribonucleoprotein F


Q8TD30_C376
GPT2 Alanine
3523



aminotransferase 2


Q9Y305_C128
ACOT9 Acyl-coenzyme A
3524



thioesterase 9, mitochondrial


Q8N163_C754
KIAA1967 DBIRD complex
3525



subunit KIAA1967


Q15149_C530
PLEC Plectin
3526


Q15149_C545
PLEC Plectin
3527


Q9BX68_C75
HINT2 Histidine triad
3528



nucleotide-binding protein 2,



mitochondrial


Q9ULW0_C145
TPX2 Targeting protein for
3529



Xklp2


O14744_C22
PRMT5 Protein arginine N-
3530



methyltransferase 5


Q5JRX3_C692
PITRM1 Presequence
3531



protease, mitochondrial


P07195_C132
LDHB L-lactate
3532



dehydrogenase B chain


Q96F07_C98
CYFIP2 Cytoplasmic FMR1-
3533



interacting protein 2


Q9P0K7_C584
RAI14 Ankycorbin
3534


P22314_C494
UBA1 Ubiquitin-like modifier-
3535



activating enzyme 1


P78527_C478
PRKDC DNA-dependent
3536



protein kinase catalytic subunit


P78527_C3187
PRKDC DNA-dependent
3537



protein kinase catalytic subunit


P78527_C3781
PRKDC DNA-dependent
3538



protein kinase catalytic subunit


P42566_C586
EPS15 Epidermal growth
3539



factor receptor substrate 15


Q86U28_C146
ISCA2 Iron-sulfur cluster
3540



assembly 2 homolog,



mitochondrial


Q96HE7_C131
ERO1L ERO1-like protein
3541



alpha


Q04724_C526
TLE1 Transducin-like
3542



enhancer protein 1


Q14789_C2664
GOLGB1 Golgin subfamily B
3543



member 1


Q9NUQ3_C101
TXLNG Gamma-taxilin
3544


Q9ULX6_C128
AKAP8L A-kinase anchor
3545



protein 8-like


Q12905_C271
ILF2 Interleukin enhancer-
3546



binding factor 2


P23588_C457
EIF4B Eukaryotic translation
3547



initiation factor 4B


P50991_C379
CCT4 T-complex protein 1
3548



subunit delta


P50991_C450
CCT4 T-complex protein 1
3549



subunit delta


B0V043_C682
VARS Valyl-tRNA synthetase
3550


P22307_C495
SCP2 Non-specific lipid-
3551



transfer protein


Q13472_C244
TOP3A DNA topoisomerase
3552



3-alpha


Q14315_C1103
FLNC Filamin-C
3553


O43747_C539
AP1G1 AP-1 complex subunit
3554



gamma-1


P23434_C85
GCSH Glycine cleavage
3555



system H protein,



mitochondrial


Q9H9A6_C23
LRRC40 Leucine-rich repeat-
3556



containing protein 40


Q8IXH7_C195
TH1L Negative elongation
3557



factor C/D


P22681_C840
CBL E3 ubiquitin-protein
3558



ligase CBL


Q9NVS2_C186
MRPS18A 28S ribosomal
3559



protein S18a, mitochondrial


Q8NF50_C2091
DOCK8 Dedicator of
3560



cytokinesis protein 8


P09110_C123
ACAA1 3-ketoacyl-CoA
3561



thiolase, peroxisomal


Q8TAF3_C342
WDR48 WD repeat-containing
3562



protein 48


Q96S55_C347
WRNIP1 ATPase WRNIP1
3563


P45973_C133
CBX5 Chromobox protein
3564



homolog 5


Q92785_C53
DPF2 Zinc finger protein ubi-
3565



d4


O43175_C254
PHGDH D-3-
3566



phosphoglycerate



dehydrogenase


P11388_C405
TOP2A DNA topoisomerase
3567



2-alpha


Q14699_C211
RFTN1 Raftlin
3568


P19367_C823
HK1 Hexokinase-1
3569


Q9BV38_C384
WDR18 WD repeat-containing
3570



protein 18


Q27J81_C38
INF2 Inverted formin-2
3571


Q27J81_C1093
INF2 Inverted formin-2
3572


Q16740_C86
CLPP Putative ATP-dependent
3573



Clp protease proteolytic



subunit


P55010_C59
EIF5 Eukaryotic translation
3574



initiation factor 5


P50213_C331
IDH3A Isocitrate
3575



dehydrogenase


Q9Y692_C113
GMEB1 Glucocorticoid
3576



modulatory element-binding



protein


Q9C0C9_C341
UBE2O Ubiquitin-conjugating
3577



enzyme E2 O


O15392_C84
BIRC5 Baculoviral IAP
3578



repeat-containing protein 5


O75533_C1035
SF3B1 Splicing factor 3B
3579



subunit 1


Q14192_C132
FHL2 Four and a half LIM
3580



domains protein 2


P33991_C162
MCM4 DNA replication
3581



licensing factor MCM4


O60684_C208
KPNA6 Importin subunit
3582



alpha-7


Q92841_C277
DDX17 Probable ATP-
3583



dependent RNA helicase



DDX17


P07814_C692
EPRS Bifunctional
3584



glutamate/proline--tRNA



ligase


P07814_C1076
EPRS Bifunctional
3585



glutamate/proline--tRNA



ligase


P22102_C733
GART Trifunctional purine
3586



biosynthetic protein adenosine-



3


P32322_C159
PYCR1 Pyrroline-5-
3587



carboxylate reductase 1,



mitochondrial


O75794_C212
CDC123 Cell division cycle
3588



protein 123 homolog


Q02750_C341
MAP2K1 Dual specificity
3589



mitogen-activated protein



kinase


Q96RL1_C257
UIMC1 BRCA1-A complex
3590



subunit RAP80


O15371_C196
EIF3D Eukaryotic translation
3591



initiation factor 3 subunit


Q7L2E3_C346
DHX30 Putative ATP-
3592



dependent RNA helicase



DHX30


O00159_C763
MYO1C Unconventional
3593



myosin-Ic


Q8WTW3_C72
COG1 Conserved oligomeric
3594



Golgi complex subunit 1


Q96KP1_C627
EXOC2 Exocyst complex
3595



component 2


P62136_C155
PPP1CA Serine/threonine-
3596



protein phosphatase PP1-alpha



catalytic


Q9UNH7_C348
SNX6 Sorting nexin-6
3597


Q86UY8_C276
NT5DC3 5-nucleotidase
3598



domain-containing protein 3


P14866_C151
HNRNPL Heterogeneous
3599



nuclear ribonucleoprotein L


P40123_C32
CAP2 Adenylyl cyclase-
3600



associated protein 2


Q86VQ1_C461
GLCCII Glucocorticoid-
3601



induced transcript 1 protein


Q13451_C394
FKBP5 Peptidyl-prolyl cis-
3602



trans isomerase FKBP5


Q9P2E9_C1216
RRBP1 Ribosome-binding
3603



protein 1


P51570_C351
GALK1 Galactokinase
3604


Q9NSE4_C155
IARS2 Isoleucine--tRNA
3605



ligase, mitochondrial


Q9BTC0_C976
DIDO1 Death-inducer
3606



obliterator 1


P07355_C335
ANXA2 Annexin A2
3607


Q5M775_C578
SPECC1 Cytospin-B
3608


P17987_C218
TCP1 T-complex protein 1
3609



subunit alpha


Q99614_C149
TTC1 Tetratricopeptide repeat
3610



protein 1


O75663_C75
TIPRL TIP41-like protein
3611


Q52LW3_C1066
ARHGAP29 Rho GTPase-
3612



activating protein 29


H3BQZ7_C405
Uncharacterized protein
3613


Q9BUL9_C16
RPP25 Ribonuclease P protein
3614



subunit p25


Q15286_C163
RAB35 Ras-related protein
3615



Rab-35


P16278_C393
GLB1 Beta-galactosidase
3616


Q9HC38_C197
GLOD4 Glyoxalase domain-
3617



containing protein 4


Q9UM22_C88
EPDR1 Mammalian
3618



ependymin-related protein 1


Q15056_C85
EIF4H Eukaryotic translation
3619



initiation factor 4H


P23284_C202
PPIB Peptidyl-prolyl cis-trans
3620



isomerase B


P46777_C100
RPL5 60S ribosomal protein
3621



L5


Q68CZ2_C928
TNS3 Tensin-3
3622


Q68CZ2_C1251
TNS3 Tensin-3
3623


P18031_C215
PTPN1 Tyrosine-protein
3624



phosphatase non-receptor type



1


O95456_C106
PSMG1 Proteasome assembly
3625



chaperone 1


O95453_C543
PARN Poly(A)-specific
3626



ribonuclease PARN


Q5VTL8_C113
PRPF38B Pre-mRNA-splicing
3627



factor 38B


P31948_C370
STIP1 Stress-induced-
3628



phosphoprotein 1


O95071_C1476
UBR5 E3 ubiquitin-protein
3629



ligase UBR5


Q9NQW6_C260
ANLN Actin-binding protein
3630



anillin


Q9NQW6_C437
ANLN Actin-binding protein
3631



anillin


Q9NQW6_C512
ANLN Actin-binding protein
3632



anillin


P51649_C502
ALDH5A1 Succinate-
3633



semialdehyde dehydrogenase,



mitochondria


P11802_C78
CDK4 Cyclin-dependent
3634



kinase 4


P49915_C631
GMPS GMP synthase
3635


Q9UKN8_C116
GTF3C4 General transcription
3636



factor 3C polypeptide 4


O60504_C482
SORBS3 Vinexin
3637


Q9Y490_C956
TLN1 Talin-1
3638


P23381_C309
WARS Tryptophan--tRNA
3639



ligase, cytoplasmic


P27708_C1696
CAD CAD protein
3640


O75607_C79
NPM3 Nucleoplasmin-3
3641


O75131_C506
CPNE3 Copine-3
3642


P38646_C66
HSPA9 Stress-70 protein,
3643



mitochondrial


P49588_C671
AARS Alanine--tRNA ligase,
3644



cytoplasmic


P07602_C33
PSAP Proactivator polypeptide
3645


P28065_C63
PSMB9 Proteasome subunit
3646



beta type-9


P15498_C794
VAV1 Proto-oncogene vav
3647


P08559_C273
PDHA1 Pyruvate
3648



dehydrogenase E1 component



subunit alpha,


Q8WZ82_C129
OVCA2 Ovarian cancer-
3649



associated gene 2 protein


P46939_C1627
UTRN Utrophin
3650


Q14166_C361
TTLL12 Tubulin--tyrosine
3651



ligase-like protein 12


O43314_C488
PPIP5K2 Inositol
3652



hexakisphosphate and



diphosphoinositol-



pentakisphosphate kinase 2


P60981_C147
DSTN Destrin
3653


A6NHR9_C444
SMCHD1 Structural
3654



maintenance of chromosomes



flexible hinge domain



containing 1


Q9Y2X0_C539
MED16 Mediator of RNA
3655



polymerase II transcription



subunit


Q5VYS8_C70
ZCCHC6 Terminal
3656



uridylyltransferase 7


P24298_C450
GPT Alanine aminotransferase
3657



1


P42331_C448
ARHGAP25 Rho GTPase-
3658



activating protein 25


Q14573_C1638
ITPR3 Inositol 1,4,5-
3659



trisphosphate receptor type 3


O75717_C716
WDHD1 WD repeat and
3660



HMG-box DNA-binding



protein 1


Q9NYV4_C723
CDK12 Cyclin-dependent
3661



kinase 12


P62487_C38
POLR2G DNA-directed RNA
3662



polymerase II subunit RPB7


Q96I99_C369
SUCLG2 Succinyl-CoA ligase
3663


O00629_C57
KPNA4 Importin subunit
3664



alpha-4


Q9BW85_C275
CCDC94 Coiled-coil domain-
3665



containing protein 94


Q9NUQ6_C367
SPATS2L SPATS2-like
3666



protein


Q5VWQ0_C282
RSBN1 Round spermatid basic
3667



protein 1


Q92835_C1050
INPP5D Phosphatidylinositol
3668



3,4,5-trisphosphate 5-



phosphatase 1


Q9Y6E0_C415
STK24 Serine/threonine-
3669



protein kinase 24


P49458_C39
SRP9 Signal recognition
3670



particle 9 kDa protein


O43795_C613
MYO1B Unconventional
3671



myosin-Ib


Q9UPN3_C4429
MACF1 Microtubule-actin
3672



cross-linking factor 1, isoforms


P16152_C122
CBR1 Carbonyl reductase
3673


Q9BWU0_C224
SLC4A1AP Kanadaptin
3674


O75369_C2115
FLNB Filamin-B
3675


P48147_C255
PREP Prolyl endopeptidase
3676


Q6PL24_C161
TMED8 Protein TMED8
3677


P21980_C10
TGM2 Protein-glutamine
3678



gamma-glutamyltransferase 2


Q16270_C59
IGFBP7 Insulin-like growth
3679



factor-binding protein 7


P25205_C446
MCM3 DNA replication
3680



licensing factor MCM3


Q16181_C280
SEPT7 Septin-7
3681


P83369_C52
LSM11 U7 snRNA-associated
3682



Sm-like protein LSm11


Q01813_C123
PFKP 6-phosphofructokinase
3683



type C


P49792_C3071
RANBP2 E3 SUMO-protein
3684



ligase RanBP2


O76031_C586
CLPX ATP-dependent Clp
3685



protease ATP-binding subunit



clp


Q5T2R2_C315
PDSS1 Decaprenyl-
3686



diphosphate synthase subunit 1


Q96T76_C356
MMS19 MMS19 nucleotide
3687



excision repair protein



homolog


Q12996_C646
CSTF3 Cleavage stimulation
3688



factor subunit 3


P35250_C255
RFC2 Replication factor C
3689



subunit 2


Q5VVQ6_C97
YOD1 Ubiquitin thioesterase
3690



OTU1


Q9BXP5_C640
SRRT Serrate RNA effector
3691



molecule homolog


P62701_C181
RPS4X 40S ribosomal protein
3692



S4, X isoform


Q09028_C138
RBBP4 Histone-binding
3693



protein RBBP4


Q8WXH0_C39
SYNE2 Nesprin-2
3694


P62633_C111
CNBP Cellular nucleic acid-
3695



binding protein


Q8N4X5_C292
AFAP1L2 Actin filament-
3696



associated protein 1-like 2


Q9HAS0_C182
C17orf75 Protein Njmu-R1
3697


O94806_C29
PRKD3 Serine/threonine-
3698



protein kinase D3


Q7Z6Z7_C2181
HUWE1 E3 ubiquitin-protein
3699



ligase HUWE1


P14598_C111
NCF1 Neutrophil cytosol
3700



factor 1


P23193_C212
TCEA1 Transcription
3701



elongation factor A protein 1


P60953_C105
CDC42 Cell division control
3702



protein 42 homolog


Q03426_C339
MVK Mevalonate kinase
3703


Q9H6S3_C358
EPS8L2 Epidermal growth
3704



factor receptor kinase substrate


P30566_C113
ADSL Adenylosuccinate lyase
3705


P51610_C352
HCFC1 Host cell factor 1
3706


Q92616_C1275
GCN1L1 Translational
3707



activator GCN1


Q92616_C2469
GCN1L1 Translational
3708



activator GCN1


Q92614_C1080
MYO18A Unconventional
3709



myosin-XVIIIa


Q9BZK7_C434
TBL1XR1 F-box-like/WD
3710



repeat-containing protein



TBL1XR1


P53618_C623
COPB1 Coatomer subunit beta
3711


Q8TEX9_C42
IPO4 Importin-4
3712


P49327_C1548
FASN Fatty acid synthase
3713


Q16875_C155
PFKFB3 6-phosphofructo-2-
3714



kinase/fructose-2,6-



bisphosphatase


P20839_C331
IMPDH1 Inosine-5-
3715



monophosphate dehydrogenase



1


P40926_C138
MDH2 Malate dehydrogenase,
3716



mitochondrial


P80297_C50
MT1X Metallothionein-1X
3717


Q12769_C1166
NUP160 Nuclear pore
3718



complex protein Nup160


P48059_C100
LIMS1 LIM and senescent cell
3719



antigen-like-containing domain


Q8TBC4_C82
UBA3 NEDD8-activating
3720



enzyme E1 catalytic subunit


P26639_C107
TARS Threonine--tRNA
3721



ligase, cytoplasmic


P13804_C53
ETFA Electron transfer
3722



flavoprotein subunit alpha,



mitochondrial


A6NE09_C148
RPSAP58 Protein RPSAP58
3723


Q12888_C513
TP53BP1 Tumor suppressor
3724



p53-binding protein 1


Q02252_C368
ALDH6A1 Methylmalonate-
3725



semialdehyde dehydrogenase


P29144_C967
TPP2 Tripeptidyl-peptidase 2
3726


Q9H1B7_C63
IRF2BPL Interferon regulatory
3727



factor 2-binding protein-like


Q99836_C280
MYD88 Myeloid
3728



differentiation primary



response protein M


P43487_C158
RANBP1 Ran-specific
3729



GTPase-activating protein


Q6KC79_C304
NIPBL Nipped-B-like protein
3730


Q9BTE3_C200
MCMBP Mini-chromosome
3731



maintenance complex-binding



protein


P42574_C170
CASP3 Caspase-3
3732


Q9NPI6_C39
DCP1A mRNA-decapping
3733



enzyme 1A


O95425_C1101
SVIL Supervillin
3734


Q9NS86_C169
LANCL2 LanC-like protein 2
3735


Q8NC60_C393
NOA1 Nitric oxide-associated
3736



protein 1


O14773_C537
TPP1 Tripeptidyl-peptidase 1
3737


P61088_C87
UBE2N Ubiquitin-conjugating
3738



enzyme E2 N


Q5JRX3_C241
PITRM1 Presequence
3739



protease, mitochondrial


Q5JRX3_C869
PITRM1 Presequence
3740



protease, mitochondrial


Q9BRP1_C100
PDCD2L Programmed cell
3741



death protein 2-like


P61981_C194
YWHAG 14-3-3 protein gamma
3742


P01871_C134
IGHM Ig mu chain C region
3743


P01871_C451
IGHM Ig mu chain C region
3744


Q5T6F2_C104
UBAP2 Ubiquitin-associated protein 2
3745


Q96TA1_C154
FAM129B Niban-like protein 1
3746


P31040_C305
SDHA Succinate dehydrogenase
3747


Q96CD2_C7
PPCDC
3748



Phosphopantothenoylcysteine



decarboxylase


Q9NVU0_C553
POLR3E DNA-directed RNA
3749



polymerase III subunit RPC5


Q92888_C911
ARHGEF1 Rho guanine nucleotide
3750



exchange factor 1


Q15020_C537
SART3 Squamous cell carcinoma
3751



antigen recognized by T-cells 3


Q15022_C46
SUZ12 Polycomb protein SUZ12
3752


Q9UQR0_C559
SCML2 Sex comb on midleg-like
3753



protein 2


Q14315_C1653
FLNC Filamin-C
3754


O94925_C266
GLS Glutaminase kidney isoform,
3755



mitochondrial


Q8NFF5_C561
FLAD1 FAD synthase
3756


Q99967_C261
CITED2 Cbp/p300-interacting
3757



transactivator 2


Q9P287_C141
BCCIP BRCA2 and CDKN1A-
3758



interacting protein


Q7LBC6_C529
KDM3B Lysine-specific demethylase
3759



3B


Q7LBC6_C569
KDM3B Lysine-specific demethylase
3760



3B


Q9UGU0_C868
TCF20 Transcription factor 20
3761


Q14683_C1073
SMC1A Structural maintenance of
3762



chromosomes protein 1A


P61513_C39
RPL37A 60S ribosomal protein L37a
3763


Q15796_C380
SMAD2 Mothers against
3764



decapentaplegic homolog 2


Q13547_C100
HDAC1 Histone deacetylase 1
3765


Q9NZT2_C330
OGFR Opioid growth factor receptor
3766


P55795_C22
HNRNPH2 Heterogeneous nuclear
3767



ribonucleoprotein H2


P51812_C229
RPS6KA3 Ribosomal protein S6 kinase
3768



alpha-3


O15294_C158
OGT UDP-N-acetylglucosamine--
3769



peptide N-acetylglucosamine (GlcNAc)



transferase


Q08211_C242
DHX9 ATP-dependent RNA helicase A
3770


O43823_C631
AKAP8 A-kinase anchor protein 8
3771


O95819_C883
MAP4K4 Mitogen-activated protein
3772



kinase kinase kinase kinase 4


Q96AE4_C332
FUBP1 Far upstream element-binding
3773



protein 1


Q99798_C592
ACO2 Aconitate hydratase,
3774



mitochondrial


Q99797_C518
M1PEP Mitochondrial intermediate
3775



peptidase


O43776_C511
NARS Asparagine--tRNA ligase,
3776



cytoplasmic


P35579_C931
MYH9 Myosin-9
3777


Q9H078_C572
CLPB Caseinolytic peptidase B protein
3778



homolog


Q02962_C52
PAX2 Paired box protein Pax-2
3779


Q9NUG6_C60
PDRG1 p53 and DNA damage-
3780



regulated protein 1


P22692_C174
IGFBP4 Insulin-like growth factor-
3781



binding protein 4


Q9BW19_C95
KIFC1 Kinesin-like protein KIFC1
3782


P62879_C294
GNB2 Guanine nucleotide-binding
3783



protein G(I)/G(S)/G(T)


Q9C0C2_C631
TNKS1BP1 182 kDa tankyrase-1-
3784



binding protein


Q9UKG1_C462
APPL1 DCC-interacting protein 13-
3785



alpha


Q12841_C113
FSTL1 Follistatin-related protein 1
3786


O43837_C232
IDH3B Isocitrate dehydrogenase
3787


P22102_C291
GART Trifunctional purine
3788



biosynthetic protein adenosine


P22102_C322
GART Trifunctional purine
3789



biosynthetic protein adenosine


P46940_C1534
IQGAP1 Ras GTPase-activating-like
3790



protein IQGAP1


P11586_C326
MTHFD1 C-1-tetrahydrofolate
3791



synthase, cytoplasmic


P27816_C181
MAP4 Microtubule-associated protein 4
3792


Q9NR46_C252
SH3GLB2 Endophilin-B2
3793


P55060_C387
CSE1L Exportin-2
3794


Q9UQ80_C179
PA2G4 Proliferation-associated protein
3795



2G4


Q9NQR4_C170
NIT2 Omega-amidase NIT2
3796


P52306_C85
RAP1GDS1 Rap1 GTPase-GDP
3797



dissociation stimulator 1


O00571_C298
DDX3X ATP-dependent RNA helicase
3798



DDX3X


Q7L5N1_C283
COPS6 COP9 signalosome complex
3799



subunit 6


Q01082_C604
SPTBN1 Spectrin beta chain, non-
3800



erythrocytic 1


O43719_C480
HTATSF1 HIV Tat-specific factor 1
3801


Q9NPB8_C640
GPCPD1 Glycerophosphocholine
3802



phosphodiesterase GPCPD1


P34932_C417
HSPA4 Heat shock 70 kDa protein 4
3803


P34932_C779
HSPA4 Heat shock 70 kDa protein 4
3804


P21291_C58
CSRP1 Cysteine and glycine-rich
3805



protein 1


Q9UHR5_C172
SAP30BP SAP30-binding protein
3806


P31937_C211
HIBADH 3-hydroxyisobutyrate
3807



dehydrogenase, mitochondrial


P04843_C477
RPN1 Dolichyl-
3808



diphosphooligosaccharide--protein



glycosyltransferase subunit 1


Q14980_C658
NUMA1 Nuclear mitotic apparatus
3809



protein 1


Q9BYV8_C171
CEP41 Centrosomal protein of 41 kDa
3810


Q8IUC6_C485
TICAM1 TIR domain-containing
3811



adapter molecule 1


Q08378_C769
GOLGA3 Golgin subfamily A member
3812



3


Q12912_C72
LRMP Lymphoid-restricted membrane
3813



protein


Q9UBD5_C711
ORC3 Origin recognition complex
3814



subunit 3


O00743_C262
PPP6C Serine/threonine-protein
3815



phosphatase 6 catalytic subunit


Q6P1J9_C145
CDC73 Parafibromin
3816


Q1KMD3_C518
HNRNPUL2 Heterogeneous nuclear
3817



ribonucleoprotein U-like protein


Q9P2J5_C70
LARS Leucine--tRNA ligase,
3818



cytoplasmic


Q9P2J5_C83
LARS Leucine--tRNA ligase,
3819



cytoplasmic


P14678_C19
SNRPB Small nuclear
3820



ribonucleoprotein-associated protein


Q9H845_C613
ACAD9 Acyl-CoA dehydrogenase
3821



family member 9, mitochondrial


Q6KB66_C49
KRT80 Keratin, type II cytoskeletal 80
3822


O43143_C190
DHX15 Putative pre-mRNA-splicing
3823



factor ATP-dependent RN


P67775_C20
PPP2CA Serine/threonine-protein
3824



phosphatase 2A catalytic


P04062_C287
GBA Glucosylceramidase
3825


Q05086_C108
UBE3A Ubiquitin-protein ligase E3A
3826


Q9NPA8_C40
ENY2 Enhancer of yellow 2
3827



transcription factor homolog


Q9NWZ3_C13
IRAK4 Interleukin-1 receptor-
3828



associated kinase 4


Q03001_C2128
DST Dystonin
3829


P48634_C437
PRRC2A Protein PRRC2A
3830


P55196_C1206
MLLT4 Afadin
3831


P55196_C1684
MLLT4 Afadin
3832


Q9P0W2_C177
HMG20B SWI/SNF-related matrix-
3833



associated actin-dependent


Q8WWI1_C261
LMO7 LIM domain only protein 7
3834


P49903_C71
SEPHS1 Selenide, water dikinase 1
3835


P52435_C31
POLR2J DNA-directed RNA
3836



polymerase II subunit RPB11-a


O43865_C292
AHCYL1 Putative
3837



adenosylhomocysteinase 2


Q92900_C188
UPF1 Regulator of nonsense transcripts
3838



1


Q92871_C57
PMM1 Phosphomannomutase 1
3839


Q15942_C433
ZYX Zyxin
3840


Q6UB35_C61
MTHFD1L Monofunctional C1-
3841



tetrahydrofolate synthase,



mitochondrial


Q9BZF9_C980
UACA Uveal autoantigen with coiled-
3842



coil domains and ankyrin repeats


Q9NYQ6_C1840
CELSR1 Cadherin EGF LAG seven-
3843



pass G-type receptor 1


O14936_C633
CASK Peripheral plasma membrane
3844



protein CASK


Q96C36_C95
PYCR2 Pyrroline-5-carboxylate
3845



reductase 2


Q2T9J0_C240
TYSND1 Peroxisomal leader peptide-
3846



processing protease


O14980_C119
XPO1 Exportin-1
3847


P31948_C471
STIP1 Stress-induced-phosphoprotein 1
3848


Q9Y2L1_C194
DIS3 Exosome complex exonuclease
3849



RRP44


Q96EB1_C412
ELP4 Elongator complex protein 4
3850


P23921_C254
RRM1 Ribonucleoside-diphosphate
3851



reductase large subunit


Q12802_C1232
AKAP13 A-kinase anchor protein 13
3852


Q13404_C144
UBE2V1 Ubiquitin-conjugating
3853



enzyme E2 variant 1


Q8TDX7_C224
NEK7 Serine/threonine-protein kinase
3854



Nek7


P27708_C2092
CAD CAD protein
3855


Q9Y4B6_C1227
VPRBP Protein VPRBP
3856


P23497_C96
SP100 Nuclear autoantigen Sp-100
3857


O75592_C2163
MYCBP2 Probable E3 ubiquitin-
3858



protein ligase MYCBP2


Q12962_C174
TAF10 Transcription initiation factor
3859



TFIID subunit 10


Q99700_C556
ATXN2 Ataxin-2
3860


Q9Y5L0_C912
TNPO3 Transportin-3
3861


A1KXE4_C63
FAM168B Myelin-associated neurite-
3862



outgrowth inhibitor


Q13671_C284
RIN1 Ras and Rab interactor 1
3863


P62913_C150
RPL11 60S ribosomal protein L11
3864


Q9H832_C100
UBE2Z Ubiquitin-conjugating enzyme
3865



E2 Z


Q00796_C301
SORD Sorbitol dehydrogenase
3866


P00491_C206
PNP Purine nucleoside phosphorylase
3867


Q9Y5U2_C99
TSSC4 Protein TSSC4
3868


O96017_C539
CHEK2 Serine/threonine-protein kinase
3869



Chk2


O96019_C152
ACTL6A Actin-like protein 6A
3870


P52701_C694
MSH6 DNA mismatch repair protein
3871



Msh6


P26440_C378
IVD Isovaleryl-CoA dehydrogenase,
3872



mitochondrial


Q16543_C308
CDC37 Hsp90 co-chaperone Cdc37
3873


Q9NUW8_C135
TDP1 Tyrosyl-DNA phosphodiesterase
3874



1


Q14139_C79
UBE4A Ubiquitin conjugation factor
3875



E4 A


Q96FV9_C49
THOC1 THO complex subunit 1
3876


P33992_C397
MCM5 DNA replication licensing
3877



factor MCM5


Q15417_C273
CNN3 Calponin-3
3878


P41567_C69
EIF1 Eukaryotic translation initiation
3879



factor 1


P30626_C162
SRI Sorcin
3880


A6NHR9_C1433
SMCHD1 Structural maintenance of
3881



chromosomes flexible hinge domain



containing 1


O00410_C348
IPO5 Importin-5
3882


O00410_C560
IPO5 Importin-5
3883


O60563_C630
CCNT1 Cyclin-T1
3884


P35580_C678
MYH10 Myosin-10
3885


P60228_C345
EIF3E Eukaryotic translation initiation
3886



factor 3 subunit


P49116_C387
NR2C2 Nuclear receptor subfamily 2
3887



group C member 2


P42330_C242
AKR1C3 Aldo-keto reductase family 1
3888



member C3


O60271_C1155
SPAG9 C-Jun-amino-terminal kinase-
3889



interacting protein 4


Q96FA3_C61
PELI1 E3 ubiquitin-protein ligase
3890



pellino homolog 1


Q96IF1_C224
AJUBA LIM domain-containing
3891



protein ajuba


Q9ULK4_C297
MED23 Mediator of RNA polymerase
3892



II transcription subunit


Q9ULK4_C1319
MED23 Mediator of RNA polymerase
3893



II transcription subunit


O00622_C359
CYR61 Protein CYR61
3894


O95985_C217
TOP3B DNA topoisomerase 3-beta-1
3895


P33240_C62
CSTF2 Cleavage stimulation factor
3896



subunit 2


P52272_C694
HNRNPM Heterogeneous nuclear
3897



ribonucleoprotein M


A0AVT1_C721
UBA6 Ubiquitin-like modifier-
3898



activating enzyme 6


Q9BZG1_C116
RAB34 Ras-related protein Rab-34
3899


P53384_C25
NUBP1 Cytosolic Fe—S cluster
3900



assembly factor NUBP1


Q15181_C114
PPA1 Inorganic pyrophosphatase
3901


Q9NPF4_C73
OSGEP Probable tRNA
3902



threonylcarbamoyladenosine



biosynthesis


Q96FF9_C195
CDCA5 Sororin
3903


Q8NFC6_C74
BOD1L1 Biorientation of chromosomes
3904



in cell division protein


Q9UPN7_C37
PPP6R1 Serine/threonine-protein
3905



phosphatase 6 regulatory


Q9UPN9_C447
TRIM33 E3 ubiquitin-protein ligase
3906



TRIM33


J3QR44_C422
CDK11B Cyclin-dependent kinase 11B
3907


Q641Q2_C594
FAM21A WASH complex subunit
3908



FAM21A


O75362_C641
ZNF217 Zinc finger protein 217
3909


P78406_C106
RAE1 mRNA export factor
3910


Q6P2I3_C215
FAHD2B Fumarylacetoacetate
3911



hydrolase domain-containing protein


P49770_C310
EIF2B2 Translation initiation factor
3912



eIF-2B subunit beta


Q9Y5A9_C482
YTHDF2 YTH domain family protein 2
3913


P25205_C319
MCM3 DNA replication licensing
3914



factor MCM3


P36959_C186
GMPR GMP reductase 1
3915


O00273_C165
DFFA DNA fragmentation factor
3916



subunit alpha


P49790_C593
NUP153 Nuclear pore complex protein
3917



Nup153


Q00610_C1528
CLTC Clathrin heavy chain 1
3918


Q9BZ67_C206
FRMD8 FERM domain-containing
3919



protein 8


Q5VZ89_C850
DENND4C DENN domain-containing
3920



protein 4C


Q8IY18_C881
SMC5 Structural maintenance of
3921



chromosomes protein 5


Q9BXP5_C490
SRRT Serrate RNA effector molecule
3922



homolog


P29692_C217
EEF1D Elongation factor 1-delta
3923


P29692_C247
EEF1D Elongation factor 1-delta
3924


P62979_C121
RPS27A Ubiquitin-40S ribosomal
3925



protein S27a


O75083_C507
WDR1 WD repeat-containing protein 1
3926


Q13131_C185
PRKAA1 5-AMP-activated protein
3927



kinase catalytic subunit


P23368_C441
ME2 NAD-dependent malic enzyme,
3928



mitochondrial


P04637_C141
TP53 Cellular tumor antigen p53
3929


Q7Z6Z7_C1074
HUWE1 E3 ubiquitin-protein ligase
3930



HUWE1


Q16643_C632
DBN1 Drebrin
3931


Q9UPQ0_C55
LIMCH1 LIM and calponin homology
3932



domains-containing protein


Q9NS91_C64
RAD18 E3 ubiquitin-protein ligase
3933



RAD18


Q7Z3D6_C124
C14orf159 UPF0317 protein
3934



C14orf159, mitochondrial


Q53EZ4_C236
CEP55 Centrosomal protein of 55 kDa
3935


P62826_C85
RAN GTP-binding nuclear protein Ran
3936


P18583_C2070
SON Protein SON
3937


Q92616_C932
GCN1L1 Translational activator GCN1
3938


P22087_C99
FBL rRNA 2-O-methyltransferase
3939



fibrillarin


Q96I24_C460
FUBP3 Far upstream element-binding
3940



protein 3


Q14657_C113
LAGE3 L antigen family member 3
3941


P49327_C2091
FASN Fatty acid synthase
3942


P49327_C2468
FASN Fatty acid synthase
3943


Q9UDR5_C534
AASS Alpha-aminoadipic
3944



semialdehyde synthase, mitochondial


Q15746_C83
MYLK Myosin light chain kinase,
3945



smooth muscle


O14929_C120
HAT1 Histone acetyltransferase type B
3946



catalytic subunit


Q9NS87_C862
KIF15 Kinesin-like protein KIF15
3947


Q8TBC4_C139
UBA3 NEDD8-activating enzyme E1
3948



catalytic subunit


Q13596_C318
SNX1 Sorting nexin-1
3949


P55160_C780
NCKAP1L Nck-associated protein 1-
3950



like


P31150_C202
GDI1 Rab GDP dissociation inhibitor
3951



alpha


Q96BN8_C47
FAM105B Protein FAM105B
3952


Q12888_C1703
TP53BP1 Tumor suppressor p53-
3953



binding protein 1


Q9NRY4_C814
ARHGAP35 Rho GTPase-activating
3954



protein 35


Q9BV68_C15
RNF126 RING finger protein 126
3955


Q92974_C715
ARHGEF2 Rho guanine nucleotide
3956



exchange factor 2


Q9HAU4_C716
SMURF2 E3 ubiquitin-protein ligase
3957



SMURF2


P24928_C1470
POLR2A DNA-directed RNA
3958



polymerase II subunit RPB1


P07858_C108
CTSB Cathepsin B
3959


O75190_C275
DNAJB6 DnaJ homolog subfamily B
3960



member 6


Q9Y6X8_C11
ZHX2 Zinc fingers and homeoboxes
3961



protein 2


P62263_C85
RPS14 40S ribosomal protein S14
3962


P31146_C195
CORO1A Coronin-1A
3963


Q9H2M9_C1336
RAB3GAP2 Rab3 GTPase-activating
3964



protein non-catalytic subunit


O60825_C105
PFKFB2 6-phosphofructo-2-
3965



kinase/fructose-2,6-bisphosphatase 2


Q9NTJ3_C271
SMC4 Structural maintenance of
3966



chromosomes protein 4


Q00577_C292
PURA Transcriptional activator protein
3967



Pur-alpha


Q5VT52_C903
RPRD2 Regulation of nuclear pre-
3968



mRNA domain-containing protein


Q9UKV3_C733
ACIN1 Apoptotic chromatin
3969



condensation inducer in the nucleus


Q92552_C49
MRPS27 28S ribosomal protein S27,
3970



mitochondrial


Q96MG7_C283
NDNL2 Melanoma-associated antigen
3971



G1


Q7L5D6_C205
GET4 Golgi to ER traffic protein 4
3972



homolog


Q8N556_C471
AFAP1 Actin filament-associated
3973



protein 1


Q8N556_C506
AFAP1 Actin filament-associated
3974



protein 1


P62987_C115
UBA52 Ubiquitin-60S ribosomal
3975



protein L40


Q96HE7_C35
ERO1L ERO1-like protein alpha
3976


Q6IBS0_C275
TWF2 Twinfilin-2
3977


Q04724_C89
TLE1 Transducin-like enhancer protein
3978



1


Q9H3U1_C650
UNC45A Protein unc-45 homolog A
3979


O43374_C797
RASA4 Ras GTPase-activating protein
3980



4


Q9NUQ8_C628
ABCF3 ATP-binding cassette sub-
3981



family F member 3


Q9UJF2_C443
RASAL2 Ras GTPase-activating
3982



protein nGAP


P61160_C11
ACTR2 Actin-related protein 2
3983


Q7Z6M1_C115
RABEPK Rab9 effector protein with
3984



kelch motifs


Q13418_C422
ILK Integrin-linked protein kinase
3985


P30153_C317
PPP2R1A Serine/threonine-protein
3986



phosphatase 2A 65 kDa regulatory



subunit A alpha isoform


P62273_C39
RPS29 40S ribosomal protein S29
3987


P61218_C76
POLR2F DNA-directed RNA
3988



polymerases I, II, and III subunit


P58546_C83
MTPN Myotrophin
3989


Q92888_C815
ARHGEF1 Rho guanine nucleotide
3990



exchange factor 1


Q9BZX2_C241
UCK2 Uridine-cytidine kinase 2
3991


O43815_C316
STRN Striatin
3992


O94925_C463
GLS Glutaminase kidney isoform,
3993



mitochondrial


P42224_C155
STAT1 Signal transducer and activator
3994



of transcription 1


P30837_C169
ALDH1B1 Aldehyde dehydrogenase X,
3995



mitochondrial


P62140_C139
PPP1CB Serine/threonine-protein
3996



phosphatase PP1-beta catalytic


Q6XQN6_C533
NAPRT1 Nicotinate
3997



phosphoribosyltransferase


Q96DM3_C333
C18orf8 Uncharacterized protein
3998



C18orf8


P33764_C53
S100A3 Protein S100-A3
3999


Q96F86_C91
EDC3 Enhancer of mRNA-decapping
4000



protein 3


O00221_C187
NFKBIE NF-kappa-B inhibitor epsilon
4001


Q9ULC4_C144
MCTS1 Malignant T-cell-amplified
4002



sequence 1


O60841_C635
EIF5B Eukaryotic translation initiation
4003



factor 5B


Q5TFE4_C179
NT5DC1 5-nucleotidase domain-
4004



containing protein 1


Q9UNM6_C114
PSMD13 26S proteasome non-ATPase
4005



regulatory subunit 13


O43847_C1109
NRD1 Nardilysin
4006


Q9HAV4_C1157
XPO5 Exportin-5
4007


O43172_C441
PRPF4 U4/U6 small nuclear
4008



ribonucleoprotein Prp4


Q8IXW5_C105
RPAP2 Putative RNA polymerase II
4009



subunit B1 CTD phosphatase


Q6QNY0_C180
BLOC1S3 Biogenesis of lysosome-
4010



related organelles complex


Q14697_C423
GANAB Neutral alpha-glucosidase AB
4011


Q27J81_C394
INF2 Inverted formin-2
4012


P60900_C137
PSMA6 Proteasome subunit alpha type-
4013



6


P55786_C66
NPEPPS Puromycin-sensitive
4014



aminopeptidase


P62879_C317
GNB2 Guanine nucleotide-binding
4015



protein G(I)/G(S)/G(T)


Q9Y692_C274
GMEB1 Glucocorticoid modulatory
4016



element-binding protein


O00567_C52
NOP56 Nucleolar protein 56
4017


Q9C0C2_C1296
TNKS1BP1 182 kDa tankyrase-1-
4018



binding protein


Q15008_C58
PSMD6 26S proteasome non-ATPase
4019



regulatory subunit 6


O75533_C677
SF3B1 Splicing factor 3B subunit 1
4020


E7EVK2_C23
MTG1 Mitochondrial GTPase 1
4021


O95336_C78
PGLS 6-phosphogluconolactonase
4022


Q9C0B1_C326
FTO Alpha-ketoglutarate-dependent
4023



dioxygenase FTO


Q8TEU7_C1368
RAPGEF6 Rap guanine nucleotide
4024



exchange factor 6


P35568_C923
IRS1 Insulin receptor substrate 1
4025


P04049_C637
RAF1 RAF proto-oncogene
4026



serine/threonine-protein kinase


P60660_C138
MYL6 Myosin light polypeptide 6
4027


Q8NDH3_C189
NPEPL1 Probable aminopeptidase
4028



NPEPL1


P25786_C182
PSMA1 Proteasome subunit alpha type-
4029



1


Q7L591_C385
DOK3 Docking protein 3
4030


Q9UJM3_C146
ERRFI1 ERBB receptor feedback
4031



inhibitor 1


O00159_C679
MYO1C Unconventional myosin-Ic
4032


P55060_C61
CSE1L Exportin-2
4033


P14868_C130
DARS Aspartate--tRNA ligase,
4034



cytoplasmic


P14868_C259
DARS Aspartate--tRNA ligase,
4035



cytoplasmic


P45954_C261
ACADSB Short/branched chain
4036



specific acyl-CoA dehydrogenase


Q01664_C29
TFAP4 Transcription factor AP-4
4037


P08138_C381
NGFR Tumor necrosis factor receptor
4038



superfamily member


O60671_C239
RAD1 Cell cycle checkpoint protein
4039



RAD1


P46379_C856
BAG6 Large proline-rich protein BAG6
4040


P26022_C103
PTX3 Pentraxin-related protein PTX3
4041


Q9BYX2_C651
TBC1D2 TBC1 domain family member
4042



2A


P23610_C76
F8A3 Factor VIII intron 22 protein
4043


Q9NZE8_C119
MRPL35 39S ribosomal protein L35,
4044



mitochondrial


Q9UJZ1_C167
STOML2 Stomatin-like protein 2
4045


P31937_C251
HIBADH 3-hydroxyisobutyrate
4046



dehydrogenase, mitochondrial


Q9NR56_C34
MBNL1 Muscleblind-like protein 1
4047


Q9P0V9_C100
SEPT10 Septin-10
4048


Q96AT9_C23
RPE Ribulose-phosphate 3-epimerase
4049


Q08378_C1431
GOLGA3 Golgin subfamily A member
4050



3


Q9Y4X5_C161
ARIH1 E3 ubiquitin-protein ligase
4051



ARIH1


P09417_C161
QDPR Dihydropteridine reductase
4052


Q7L014_C377
DDX46 Probable ATP-dependent RNA
4053



helicase DDX46


Q7L014_C501
DDX46 Probable ATP-dependent RNA
4054



helicase DDX46


Q92917_C137
GPKOW G patch domain and KOW
4055



motifs-containing protein


P28340_C1058
POLD1 DNA polymerase delta
4056



catalytic subunit


P53350_C212
PLK1 Serine/threonine-protein kinase
4057



PLK1


Q86VP6_C942
CAND1 Cullin-associated NEDD8-
4058



dissociated protein 1


P35237_C350
SERPINB6 Serpin B6
4059


P67775_C266
PPP2CA Serine/threonine-protein
4060



phosphatase 2A catalytic


Q14152_C478
EIF3A Eukaryotic translation initiation
4061



factor 3 subunit


P19338_C543
NCL Nucleolin
4062


Q16576_C277
RBBP7 Histone-binding protein
4063



RBBP7


Q5UIP0VC2274
RIF1 Telomere-associated protein RIF1
4064


O60566_C578
BUB1B Mitotic checkpoint
4065



serine/threonine-protein kinase


O60566_C723
BUB1B Mitotic checkpoint
4066



serine/threonine-protein kinase


Q9UBU9_C252
NXF1 Nuclear RNA export factor 1
4067


P41134_C34
ID1 DNA-binding protein inhibitor ID-
4068



1


Q03001_C5610
DST Dystonin
4069


P49720_C19
PSMB3 Proteasome subunit beta type-3
4070


Q15054_C129
POLD3 DNA polymerase delta subunit
4071



3


Q9Y223_C183
GNE Bifunctional UDP-N-
4072



acetylglucosamine 2-epimerase/N


P31323_C373
PRKAR2B cAMP-dependent protein
4073



kinase type II-beta regulatory subunit



beta


Q08257_C145
CRYZ Quinone oxidoreductase
4074


P18031_C344
PTPN1 Tyrosine-protein phosphatase
4075



non-receptor type 1


P04075_C240
ALDOA Fructose-bisphosphate
4076



aldolase A


Q8WYP5_C1261
AHCTF1 Protein ELYS
4077


Q14145_C3I9
KEAP1 Kelch-like ECH-associated
4078



protein 1


Q14141_C432
SEPT6 Septin-6
4079


P46821_C261
MAP1B Microtubule-associated protein
4080



1B


O00291_C249
HIP1 Huntingtin-interacting protein 1
4081


Q96A65_C106
EXOC4 Exocyst complex component 4
4082


P34896_C389
SHMT1 Serine
4083



hydroxymethyltransferase, cytosolic


Q6XZF7_C327
DNMBP Dynamin-binding protein
4084


O95671_C274
ASMTL N-acetylserotonin O-
4085



methyltransferase-like protein


P09960_C147
LTA4H Leukotriene A-4 hydrolase
4086


P09960_C200
LTA4H Leukotriene A-4 hydrolase
4087


Q86WB0_C125
ZC3HC1 Nuclear-interacting partner of
4088



ALK


Q96EP5_C63
DAZAP1 DAZ-associated protein 1
4089


Q9Y490_C732
TLN1 Talin-1
4090


Q9Y490_C1506
TLN1 Talin-1
4091


P27708_C2161
CAD CAD protein
4092


O95628_C175
CNOT4 CCR4-NOT transcription
4093



complex subunit 4


Q02535_C16
ID3 DNA-binding protein inhibitor ID-
4094



3


P23497_C238
SP100 Nuclear autoantigen Sp-100
4095


P23497_C468
SP100 Nuclear autoantigen Sp-100
4096


Q8IV63_C191
VRK3 Inactive serine/threonine-protein
4097



kinase VRK3


Q7L5Y1_C307
ENOSF1 Mitochondrial enolase
4098



superfamily member 1


Q9UBW7_C1331
ZMYM2 Zinc finger MYM-type
4099



protein 2


O15446_C86
CD3EAP DNA-directed RNA
4100



polymerase I subunit RPA34


P54136_C312
RARS Arginine-tRNA ligase,
4101



cytoplasmic


P49748_C215
ACADVL Very long-chain specific
4102



acyl-CoA dehydrogenase,



mitochondrial


Q9BRX2VC175
PELO Protein pelota homolog
4103


O95544_C69
NADK NAD kinase
4104


Q969W3_C159
FAM104A Protein FAM104A
4105


P62917_C195
RPL8 60S ribosomal protein L8
4106


Q00839_C335
HNRNPU Heterogeneous nuclear
4107



ribonucleoprotein U


P00568_C25
AK1 Adenylate kinase isoenzyme 1
4108


D6RAD4_C275
CDK7 Cyclin-dependent kinase 7
4109


P49368_C475
CCT3 T-complex protein 1 subunit
4110



gamma


Q53S33_C59
BOLA3 BolA-like protein 3
4111


Q96A49_C283
SYAP1 Synapse-associated protein 1
4112


Q6ZS81_C1665
WDFY4 WD repeat- and FYVE
4113



domain-containing protein 4


P60981_C39
DSTN Destrin
4114


P51531_C1296
SMARCA2 Probable global
4115



transcription activator SNF2L2


Q7Z417_C234
NUFIP2 Nuclear fragile X mental
4116



retardation-interacting protein


O00410_C180
IPO5 Importin-5
4117


O00410_C972
IPO5 Importin-5
4118


Q9NTK5_C187
OLA1 Obg-like ATPase 1
4119


P60228_C350
EIF3E Eukaryotic translation initiation
4120



factor 3 subunit


Q96CP2_C132
FLYWCH2 FLYWCH family member
4121



2


H0YGG7_C34
Uncharacterized protein
4122


Q92538_C1766
GBF1 Golgi-specific brefeldin A-
4123



resistance guanine nucleus


O95081_C39
AGFG2 Arf-GAP domain and FG
4124



repeat-containing protein 2


Q16531_C977
DDB1 DNA damage-binding protein 1
4125


P28482_C254
MAPK1 Mitogen-activated protein
4126



kinase 1


P36578_C208
RPL4 60S ribosomal protein L4
4127


Q8NC26_C75
ZNF114 Zinc finger protein 114
4128


Q9BQ69_C199
MACROD1 O-acetyl-ADP-ribose
4129



deacetylase MACROD1


B2RTY4_C2032
MYO9A Unconventional myosin-IXa
4130


Q9NZL9_C17
MAT2B Methionine
4131



adenosyltransferase 2 subunit beta


P30291_C19
WEE1 Wee1-like protein kinase
4132


Q53ET0_C675
CRTC2 CREB-regulated transcription
4133



coactivator 2


P02765_C219
AHSG Alpha-2-HS-glycoprotein
4134


Q96T60_C353
PNKP Bifunctional polynucleotide
4135



phosphatase/kinase


P43034_C252
PAFAH1B1 Platelet-activating factor
4136



acetylhydrolase 1B subunit


Q9P215_C39
POGK Pogo transposable element with
4137



KRAB domain


P09001_C338
MRPL3 39S ribosomal protein L3,
4138



mitochondrial


Q8NFC6_C2164
BOD1L1 Biorientation of chromosomes
4139



in cell division protein


Q13126_C136
MTAP S-methyl-5-thioadenosine
4140



phosphorylase


Q9Y6I3_C205
EPN1 Epsin-1
4141


Q9HA47_C236
UCK1 Uridine-cytidine kinase 1
4142


Q96KG9_C88
SCYL1 N-terminal kinase-like protein
4143


P49419_C70
ALDH7A1 Alpha-aminoadipic
4144



semialdehyde dehydrogenase


Q96RU3_C511
FNBP1 Formin-binding protein 1
4145


Q96RU2_C733
USP28 Ubiquitin carboxyl-terminal
4146



hydrolase 28


Q16270_C71
IGFBP7 Insulin-like growth factor-
4147



binding protein 7


P50395_C302
GDI2 Rab GDP dissociation inhibitor
4148



beta


P50395_C414
GDI2 Rab GDP dissociation inhibitor
4149



beta


P40306_C17
PSMB10 Proteasome subunit beta type-
4150



10


Q16181_C204
SEPT7 Septin-7
4151


P60891_C41
PRPS1 Ribose-phosphate
4152



pyrophosphokinase 1


Q00403_C223
GTF2B Transcription initiation factor
4153



IIB


O95816_C142
BAG2 BAG family molecular
4154



chaperone regulator 2


Q00610_C926
CLTC Clathrin heavy chain 1
4155


Q00610_C1102
CLTC Clathrin heavy chain 1
4156


Q12996_C176
CSTF3 Cleavage stimulation factor
4157



subunit 3


Q9BXB5_C33
OSBPL10 Oxysterol-binding protein-
4158



related protein 10


P46013_C475
MKI67 Antigen KI-67
4159


P46013_C1251
MKI67 Antigen KI-67
4160


O94979_C704
SEC31A Protein transport protein
4161



Sec31A


O75083_C170
WDR1 WD repeat-containing protein 1
4162


O43252_C53
PAPSS1 Bifunctional 3-
4163



phosphoadenosine 5-phosphosulfate


Q13131_C117
PRKAA1 5-AMP-activated protein
4164



kinase catalytic subunit


P62633_C158
CNBP Cellular nucleic acid-binding
4165



protein


P52732_C695
KIF11 Kinesin-like protein KIF11
4166


Q8TD16_C437
BICD2 Protein bicaudal D homolog 2
4167


Q14008_C1768
CKAP5 Cytoskeleton-associated
4168



protein 5


P60604_C89
UBE2G2 Ubiquitin-conjugating
4169



enzyme E2 G2


Q9UHY1_C478
NRBP1 Nuclear receptor-binding
4170



protein


Q9BPX3_C317
NCAPG Condensin complex subunit 3
4171


Q9NZJ9_C131
NUDT4 Diphosphoinositol
4172



polyphosphate phosphohydrolase 2


P21333_C1165
FLNA Filamin-A
4173


P13010_C296
XRCC5 X-ray repair cross-
4174



complementing protein 5


Q9NRX1_C64
PNO1 RNA-binding protein PNO1
4175


Q9NRX2_C129
MRPL17 39S ribosomal protein L17,
4176



mitochondrial


O75414_C163
NME6 Nucleoside diphosphate kinase 6
4177


Q96CU9_C116
FOXRED1 FAD-dependent
4178



oxidoreductase domain-containing



protein


Q6DN90_C485
IQSEC1 IQ motif and SEC7 domain-
4179



containing protein 1


P01033_C168
TIMP1 Metalloproteinase inhibitor 1
4180


Q92616_C1161
GCN1L1 Translational activator GCN1
4181


Q53GL7_C50
PARP10 Poly
4182


Q9UH65_C260
SWAP70 Switch-associated protein 70
4183


Q9UH65_C261
SWAP70 Switch-associated protein 70
4184


P46060_C338
RANGAP1 Ran GTPase-activating
4185



protein 1


P68402_C35
PAFAH1B2 Platelet-activating factor
4186



acetylhydrolase IB subunit


P61964_C205
WDR5 WD repeat-containing protein 5
4187


P49327_C223
FASN Fatty acid synthase
4188


Q99536_C86
VAT1 Synaptic vesicle membrane
4189



protein VAT-1 homolog


Q8N1G4_C249
LRRC47 Leucine-rich repeat-
4190



containing protein 47


O14972_C221
DSCR3 Down syndrome critical region
4191



protein 3


O60232_C125
SSSCA1 Sjoegren
4192



syndrome/scleroderma autoantigen 1


O95619_C210
YEATS4 YEATS domain-containing
4193



protein 4


P57772_C93
EEFSEC Selenocysteine-specific
4194



elongation factor


P13489_C248
RNH1 Ribonuclease inhibitor
4195


P13489_C362
RNH1 Ribonuclease inhibitor
4196


Q8ND83_C449
SLAIN1 SLAIN motif-containing
4197



protein 1


Q9BUK6_C411
MSTO1 Protein misato homolog 1
4198


Q12888_C329
TP53BP1 Tumor suppressor p53-
4199



binding protein 1


Q15910_C14
EZH2 Histone-lysine N-
4200



methyltransferase EZH2


Q99832_C370
CCT7 T-complex protein 1 subunit eta
4201


Q9BZH6_C363
WDR11 WD repeat-containing protein
4202



11


Q07864_C1935
POLE DNA polymerase epsilon
4203



catalytic subunit A


Q92974_C383
ARHGEF2 Rho guanine nucleotide
4204



exchange factor 2


Q9BTE3_C636
MCMBP Mini-chromosome
4205



maintenance complex-binding protein


P54578_C203
USP14 Ubiquitin carboxyl-terminal
4206



hydrolase 14


P54578_C415
USP14 Ubiquitin carboxyl-terminal
4207



hydrolase 14


O75995_C152
SASH3 SAM and SH3 domain-
4208



containing protein 3


O95425_C671
SVIL Supervillin
4209


Q9UHI6_C577
DDX20 Probable ATP-dependent RNA
4210



helicase DDX20


Q9H9Q2_C240
COPS7B COP9 signalosome complex
4211



subunit 7b


P62191_C58
PSMC1 26S protease regulatory subunit
4212



4


P62195_C363
PSMC5 26S protease regulatory subunit
4213



8


P11413_C294
G6PD Glucose-6-phosphate 1-
4214



dehydrogenase


P11142_C267
HSPA8 Heat shock cognate 71 kDa
4215



protein


Q9NQX3_C419
GPHN Gephyrin
4216


P61081_C47
UBE2M NEDD8-conjugating enzyme
4217



Ubc12


Q9Y6W3_C767
CAPN7 Calpain-7
4218


Q01844_C524
EWSR1 RNA-binding protein EWS
4219


Q9Y2Q3_C27
GSTK1 Glutathione S-transferase
4220



kappa 1


O60825_C28
PFKFB2 6-phosphofructo-2-
4221



kinase/fructose-2,6-bisphosphatase


Q9GZV4_C73
EIF5A2 Eukaryotic translation
4222



initiation factor 5A-2


Q9NXV6_C24
CDKN2AIP CDKN2A-interacting
4223



protein


Q9UID3_C316
VPS51 Vacuolar protein sorting-
4224



associated protein 51 homolog


Q99829_C30
CPNE1 Copine-1
4225


Q5VT52_C416
RPRD2 Regulation of nuclear pre-
4226



mRNA domain-containing protein 2


P22314_C906
UBA1 Ubiquitin-like modifier-
4227



activating enzyme 1


Q9UKV3_C691
ACIN1 Apoptotic chromatin
4228



condensation inducer in the nucleus


Q86U28_C144
ISCA2 Iron-sulfur cluster assembly 2
4229



homolog, mitochondrial


Q15814_C184
TBCC Tubulin-specific chaperone C
4230


P42695_C1484
NCAPD3 Condensin-2 complex subunit
4231



D3


Q14493_C72
SLBP Histone RNA hairpin-binding
4232



protein


Q14258_C498
TRIM25 E3 ubiquitin/ISG15 ligase
4233



TRIM25


Q9H3U1_C384
UNC45A Protein unc-45 homolog A
4234


O43374_C396
RASA4 Ras GTPase-activating protein
4235



4


P82921_C49
MRPS21 28S ribosomal protein S21,
4236



mitochondrial


P20810_C241
CAST Calpastatin
4237


P20810_C413
CAST Calpastatin
4238


Q9Y5S9_C149
RBM8A RNA-binding protein 8A
4239


P31997_C299
CEACAM8 Carcinoembryonic antigen-
4240



related cell adhesion molecule 8


Q9ULV4_C39
CORO1C Coronin-1C
4241


PI1172_C174
UMPS Uridine 5-monophosphate
4242



synthase


Q6NXE6_C297
ARMC6 Armadillo repeat-containing
4243



protein 6


Q92797_C578
SYMPK Symplekin
4244


P45984_C116
MAPK9 Mitogen-activated protein
4245



kinase 9


P50995_C294
ANXA11 Annexin A11
4246


O95376_C161
ARIH2 E3 ubiquitin-protein ligase
4247



ARIH2


B0V043_C381
VARS Valyl-tRNA synthetase
4248


B0V043_C444
VARS Valyl-tRNA synthetase
4249


P49848_C130
TAF6 Transcription initiation factor
4250



TFIID subunit 6


Q86UV5_C850
USP48 Ubiquitin carboxyl-terminal
4251



hydrolase 48


Q9Y2H0_C726
DLGAP4 Disks large-associated protein
4252



4


Q92947_C176
GCDH Glutaryl-CoA dehydrogenase,
4253



mitochondrial


Q9UKW4_C800
VAV3 Guanine nucleotide exchange
4254



factor VAV3


P35610_C92
SOAT1 Sterol O-acyltransferase 1
4255


Q14318_C274
FKBP8 Peptidyl-prolyl cis-trans
4256



isomerase FKBP8


Q14315_C2154
FLNC Filamin-C
4257


P22234_C281
PAICS Multifunctional protein ADE2
4258


P22234_C423
PAICS Multifunctional protein ADE2
4259


Q969Z0_C370
TBRG4 Protein TBRG4
4260


Q8WUM4_C40
PDCD6IP Programmed cell death 6-
4261



interacting protein


Q9H9A6_C264
LRRC40 Leucine-rich repeat-
4262



containing protein 40


P33764_C30
S100A3 Protein S100-A3
4263


P38936_C117
CDKN1A Cyclin-dependent kinase
4264



inhibitor 1


Q9UPU5_C1362
USP24 Ubiquitin carboxyl-terminal
4265



hydrolase 24


Q8IWD4_C81
CCDC117 Coiled-coil domain-
4266



containing protein 117


Q96GM8_C80
TOE1 Target of EGR1 protein 1
4267


Q9UJY4_C347
GGA2 ADP-ribosylation factor-binding
4268



protein GGA2


P12236_C129
SLC25A6 ADP/ATP translocase 3
4269


Q9NXH9_C620
TRMT1 tRNA (guanine(26)-N(2))-
4270



dimethyltransferase


Q7L0Y3_C123
TRMT10C Mitochondrial ribonuclease
4271



P protein 1


Q08211_C12
DHX9 ATP-dependent RNA helicase A
4272


Q9Y4I1_C535
MYO5A Unconventional myosin-Va
4273


P08240_C253
SRPR Signal recognition particle
4274



receptor subunit alpha


Q5TFE4_C399
NT5DC1 5-nucleotidase domain-
4275



containing protein 1


Q8NFW8_C364
CMAS N-acylneuraminate
4276



cytidylyltransferase


O95817_C373
BAG3 BAG family molecular
4277



chaperone regulator 3


Q92541_C599
RTF1 RNA polymerase-associated
4278



protein RTF1 homolog


P52789_C375
HK2 Hexokinase-2
4279


P52789_C813
HK2 Hexokinase-2
4280


Q01469_C87
FABP5 Fatty acid-binding protein,
4281



epidermal


O43172_C342
PRPF4 U4/U6 small nuclear
4282



ribonucleoprotein Prp4


O43175_C48
PHGDH D-3-phosphoglycerate
4283



dehydrogenase


O43175_C234
PHGDH D-3-phosphoglycerate
4284



dehydrogenase


P22059_C344
OSBP Oxysterol-binding protein 1
4285


Q14699_C551
RFTN1 Raftlin
4286


Q14697_C822
GANAB Neutral alpha-glucosidase AB
4287


Q15654_C310
TRIP6 Thyroid receptor-interacting
4288



protein 6


Q15654_C328
TRIP6 Thyroid receptor-interacting
4289



protein 6


Q15652_C684
JMJD1C Probable JmjC domain-
4290



containing histone demethylation



protein 2C


Q9NU22_C1867
MDN1 Midasin
4291


Q13439_C1862
GOLGA4 Golgin subfamily A member
4292



4


Q9UPT8_C1302
ZC3H4 Zinc finger CCCH domain-
4293



containing protein 4


Q9NXG2_C169
THUMPD1 THUMP domain-
4294



containing protein 1


Q27J81_C1029
INF2 Inverted formin-2
4295


P01892_C188
HLA-A HLA class I histocompatibility
4296



antigen, A-2 alpha


P60903_C62
S100A10 Protein S100-A10
4297


P51553_C236
IDH3G Isocitrate dehydrogenase
4298


P51003_C36
PAPOLA Poly(A) polymerase alpha
4299


P50213_C351
IDH3A Isocitrate dehydrogenase
4300


P62873_C204
GNB1 Guanine nucleotide-binding
4301



protein G(I)/G(S)/G(T)


Q15003_C255
NCAPH Condensin complex subunit 2
4302


O00764_C273
PDXK Pyridoxal kinase
4303


Q9BZL6_C217
PRKD2 Serine/threonine-protein kinase
4304



D2


O75534_C506
CSDE1 Cold shock domain-containing
4305



protein E1


Q9C0B1_C397
FTO Alpha-ketoglutarate-dependent
4306



dioxygenase FTO


O75223_C42
GGCT Gamma-
4307



glutamylcyclotransferase


Q13155_C168
AIMP2 Aminoacyl tRNA synthase
4308



complex-interacting multifunctional



protein 2


Q14204_C3389
DYNC1H1 Cytoplasmic dynein 1
4309



heavy chain 1


Q8WXI9_C409
GATAD2B Transcriptional repressor
4310



p66-beta


P07814_C1301
EPRS Bifunctional glutamate/proline--
4311



tRNA ligase


P22102_C62
GART Trifunctional purine
4312



biosynthetic protein adenosine


O75643_C428
SNRNP200 U5 small nuclear
4313



ribonucleoprotein 200 kDa helicase


Q9ULL5_C173
PRR12 Proline-rich protein 12
4314


Q14738_C484
PPP2R5D Serine/threonine-protein
4315



phosphatase 2A 56 kDa regulatory


P50851_C1843
LRBA Lipopolysaccharide-responsive
4316



and beige-like anchor protein


Q9H668_C8
OBFC1 CST complex subunit STN1
4317


Q15643_C1329
TRIP11 Thyroid receptor-interacting
4318



protein 11


Q13422_C394
IKZF1 DNA-binding protein Ikaros
4319


P48739_C94
PITPNB Phosphatidylinositol transfer
4320



protein beta isoform


Q9UJM3_C378
ERRFI1 ERBB receptor feedback
4321



inhibitor 1


P62136_C140
PPP1CA Serine/threonine-protein
4322



phosphatase PP1-alpha catalytic


P13674_C528
P4HA1 Prolyl 4-hydroxylase subunit
4323



alpha-1


Q9NVX2_C280
NLE1 Notchless protein homolog 1
4324


Q6IA86_C68
ELP2 Elongator complex protein 2
4325


P45954_C308
ACADSB Short/branched chain
4326



specific acyl-CoA dehydrogenase


O94921_C100
CDK14 Cyclin-dependent kinase 14
4327


Q3KQU3_C361
MAP7D1 MAP7 domain-containing
4328



protein 1


Q8IVM0_C85
CCDC50 Coiled-coil domain-
4329



containing protein 50


P52630_C74
STAT2 Signal transducer and activator
4330



of transcription 2


P52630_C529
STAT2 Signal transducer and activator
4331



of transcription 2


P42704_C571
LRPPRC Leucine-rich PPR motif-
4332



containing protein, mitochondrial


P42704_C1043
LRPPRC Leucine-rich PPR motif-
4333



containing protein, mitocho


Q99598_C202
TSNAX Translin-associated protein X
4334


P34932_C376
HSPA4 Heat shock 70 kDa protein 4
4335


Q14980_C65
NUMA1 Nuclear mitotic apparatus
4336



protein 1


Q14980_C1367
NUMA1 Nuclear mitotic apparatus
4337



protein 1


Q9BYV8_C274
CEP41 Centrosomal protein of 41 kDa
4338


P51970_C66
NDUFA8 NADH dehydrogenase
4339


Q01433_C230
AMPD2 AMP deaminase 2
4340


P55212_C68
CASP6 Caspase-6
4341


Q5SW79_C235
CEP170 Centrosomal protein of 170
4342



kDa


Q9NQG5_C234
RPRD1B Regulation of nuclear pre-
4343



mRNA domain-containing protein


O00743_C265
PPP6C Serine/threonine-protein
4344



phosphatase 6 catalytic subunit


PI0515_C586
DLAT Dihydrolipoyllysine-residue
4345



acetyltransferase component of



pyruvate dehydrogenase complex,



mitochondiral


P28340_C360
POLD1 DNA polymerase delta
4346



catalytic subunit


P28340_C1029
POLD1 DNA polymerase delta
4347



catalytic subunit


Q86VP6_C179
CAND1 Cullin-associated NEDD8-
4348



dissociated protein 1


Q86VP6_C954
CAND1 Cullin-associated NEDD8-
4349



dissociated protein 1


P54886_C486
ALDH18A1 Delta-1-pyrroline-5-
4350



carboxylate synthase


P54886_C546
ALDH18A1 Delta-l-pyrroline-5-
4351



carboxylate synthase


Q8N0X7_C288
SPG20 Spartin
4352


Q8TB52_C723
FBXO30 F-box only protein 30
4353


Q14152_C404
EIF3A Eukaryotic translation initiation
4354



factor 3 subunit


P21281_C112
ATP6V1B2 V-type proton ATPase
4355



subunit B, brain isoform


P21281_C207
ATP6V1B2 V-type proton ATPase
4356



subunit B, brain isoform


O75116_C804
ROCK2 Rho-associated protein kinase
4357



2


Q5UIP0_C2169
RIF1 Telomere-associated protein RIF1
4358


Q9BW27_C515
NUP85 Nuclear pore complex protein
4359



Nup85


P55199_C70
ELL RNA polymerase II elongation
4360



factor ELL


Q8WXE1_C74
ATRIP ATR-interacting protein
4361


O14526_C571
FCHO1 FCH domain only protein 1
4362


Q9NSD9_C362
FARSB Phenylalanine--tRNA ligase
4363



beta subunit


Q8WUW1_C43
BRK1 Protein BRICK1
4364


Q12874_C145
SF3A3 Splicing factor 3A subunit 3
4365


Q9Y6A5_C20
TACC3 Transforming acidic coiled-
4366



coil-containing protein


Q9Y6A5_C426
TACC3 Transforming acidic coiled-
4367



coil-containing protein


Q92878_C133
RAD50 DNA repair protein RAD50
4368


Q9BXK1_C233
KLF16 Krueppel-like factor 16
4369


Q68CZ2_C842
TNS3 Tensin-3
4370


O75616_C86
ERAL1 GTPase Era, mitochondrial
4371


P18031_C32
PTPN1 Tyrosine-protein phosphatase
4372



non-receptor type 1


Q9UHB6_C316
LIMA1 LIM domain and actin-binding
4373



protein 1


Q9UHB6_C414
LIMA1 LIM domain and actin-binding
4374



protein 1


Q9NZ52_C396
GGA3 ADP-ribosylation factor-binding
4375



protein GGA3


Q9UBT2_C185
UBA2 SUMO-activating enzyme
4376



subunit 2


Q15723_C470
ELF2 ETS-related transcription factor
4377



Elf-2


Q9H5V9_C11
CXorf56 UPF0428 protein CXorf56
4378


O14980_C199
XPO1 Exportin-1
4379


P15104_C53
GLUL Glutamine synthetase
4380


P13796_C206
LCP1 Plastin-2
4381


O95071_C2084
UBR5 E3 ubiquitin-protein ligase
4382



UBR5


Q6XZF7_C909
DNMBP Dynamin-binding protein
4383


Q9NXR7_C34
BRE BRCA1-A complex subunit BRE
4384


Q9NQW6_C61
ANLN Actin-binding protein anillin
4385


Q9NQW6_C234
ANLN Actin-binding protein anillin
4386


Q6P587_C129
FAHD1 Acylpyruvase FAHD1,
4387



mitochondrial


Q8NC96_C162
NECAP1 Adaptin ear-binding coat-
4388



associated protein 1


Q00653_C738
NFKB2 Nuclear factor NF-kappa-B
4389



p100 subunit


Q86W56_C603
PARG Poly(ADP-ribose)
4390



glycohydrolase


P39748_C182
FEN1 Flap endonuclease 1
4391


Q9Y3Z3_C320
SAMHD1 SAM domain and HD
4392



domain-containing protein 1


Q13045_C1265
FLH Protein flightless-1 homolog
4393


Q14558_C19
PRPSAP1 Phosphoribosyl
4394



pyrophosphate synthase-associated



protein 1


O75592_C3152
MYCBP2 Probable E3 ubiquitin-
4395



protein ligase MYCBP2


Q8IUR0_C40
TRAPPC5 Trafficking protein particle
4396



complex subunit 5


Q16822_C92
PCK2 Phosphoenolpyruvate
4397



carboxykinase


Q53H96_C129
PYCRL Pyrroline-5-carboxylate
4398



reductase 3


Q96F24_C126
NRBF2 Nuclear receptor-binding factor
4399



2


H3BQ06_C89
Uncharacterized protein
4400


Q06546_C421
GABPA GA-binding protein alpha
4401



chain


P56192_C309
MARS Methionine--tRNA ligase,
4402



cytoplasmic


Q9Y485_C1419
DMXL1 DmX-like protein 1
4403


Q00839_C408
HNRNPU Heterogeneous nuclear
4404



ribonucleoprotein U


Q92499_C631
DDX1 ATP-dependent RNA helicase
4405



DDX1


O43663_C531
PRC1 Protein regulator of cytokinesis 1
4406


O14879_C239
IFIT3 Interferon-induced protein with
4407



tetratricopeptide


P36969_C134
GPX4 Phospholipid hydroperoxide
4408



glutathione peroxidase,


P12081_C235
HARS Histidine--tRNA ligase,
4409



cytoplasmic


P50914_C54
RPL14 60S ribosomal protein L14
4410


Q9H0D6_C547
XRN2 5-3 exoribonuclease 2
4411


Q14C86_C1129
GAPVD1 GTPase-activating protein
4412



and VPS9 domain-containi


Q9BXF6_C106
RAB11FIP5 Rab11 family-interacting
4413



protein 5


A6NHR9_C1856
SMCHD1 Structural maintenance of
4414



chromosomes flexible hin


Q9BW92_C322
TARS2 Threonine--tRNA ligase,
4415



mitochondrial


P83916_C156
CBX1 Chromobox protein homolog 1
4416


O00410_C229
IPO5 Importin-5
4417


Q5VUA4_C1681
ZNF318 Zinc finger protein 318
4418


Q96SY0_C193
C15orf44 UPF0464 protein C15orf44
4419


Q9NS18_C77
GLRX2 Glutaredoxin-2, mitochondrial
4420


P46109_C44
CRKL Crk-like protein
4421


Q14289_C677
PTK2B Protein-tyrosine kinase 2-beta
4422


Q14289_C972
PTK2B Protein-tyrosine kinase 2-beta
4423


O75718_C317
CRTAP Cartilage-associated protein
4424


Q86Y37_C94
CACUL1 CDK2-associated and cullin
4425



domain-containing protein


P16144_C1553
ITGB4 Integrin beta-4
4426


Q9BY42_C51
C20orf43 UPF0549 protein C20orf43
4427


Q8ND56_C375
LSM14A Protein LSM14 homolog A
4428


P40121_C165
CAPG Macrophage-capping protein
4429


P78347_C745
GTF2I General transcription factor II-I
4430


P78347_C903
GTF2I General transcription factor II-I
4431


P16885_C496
PLCG2 1-phosphatidylinositol 4,5-
4432



bisphosphate phosphodiese


Q9H814_C87
PHAX Phosphorylated adapter RNA
4433



export protein


P29401_C41
TKT Transketolase
4434


P35249_C141
RFC4 Replication factor C subunit 4
4435


Q92835_C956
INPP5D Phosphatidylinositol 3,4,5-
4436



trisphosphate 5-phosphatase


Q9Y6E0_C375
STK24 Serine/threonine-protein kinase
4437



24


O75380_C87
NDUFS6 NADH dehydrogenase
4438


Q9Y4G6_C1954
TLN2 Talin-2
4439


Q9NYG5_C7
ANAPC11 Anaphase-promoting
4440



complex subunit 11


Q9UPN3_C5131
MACF1 Microtubule-actin cross-
4441



linking factor 1, isoforms


P53634_C448
CTSC Dipeptidyl peptidase 1
4442


Q96HA7_C830
TONSL Tonsoku-like protein
4443


A5YKK6_C677
CNOT1 CCR4-NOT transcription
4444



complex subunit 1


Q9BWU0_C125
SLC4A1AP Kanadaptin
4445


Q9BWU0_C730
SLC4A1AP Kanadaptin
4446


P40763_C718
STAT3 Signal transducer and activator
4447



of transcription 3


Q96RU3_C555
FNBP1 Formin-binding protein 1
4448


Q96HS1_C168
PGAM5 Serine/threonine-protein
4449



phosphatase PGAM5, mitochondrial


Q6YN16_C136
HSDL2 Hydroxysteroid
4450



dehydrogenase-like protein 2


P05067_C98
APP Amyloid beta A4 protein
4451


Q96RE7_C85
NACC1 Nucleus accumbens-associated
4452



protein 1


P49959_C336
MRE11A Double-strand break repair
4453



protein MRE11A


Q01813_C232
PFKP 6-phosphofructokinase type C
4454


P49792_C348
RANBP2 E3 SUMO-protein ligase
4455



RanBP2


P49792_C1296
RANBP2 E3 SUMO-protein ligase
4456



RanBP2


Q93008_C1566
USP9X Probable ubiquitin carboxyl-
4457



terminal hydrolase FAF


Q9BY89_C817
KIAA1671 Uncharacterized protein
4458



KIAA1671


Q5SRE5_C1445
NUP188 Nucleoporin NUP188
4459



homolog


Q92665_C356
MRPS31 28S ribosomal protein S31,
4460



mitochondrial


P18669_C55
PGAM1 Phosphoglycerate mutase 1
4461


Q9Y4P8_C70
WIPI2 WD repeat domain
4462



phosphoinositide-interacting protein


Q9Y4P1_C189
ATG4B Cysteine protease ATG4B
4463


Q9BZD4_C285
NUF2 Kinetochore protein Nuf2
4464


Q01581_C406
HMGCS1 Hydroxymethylglutaryl-CoA
4465



synthase, cytoplasmic


P78344_C677
EIF4G2 Eukaryotic translation
4466



initiation factor 4 gamma 2


Q92609_C753
TBC1D5 TBC1 domain family member
4467



5


Q9BSJ8_C890
ESYT1 Extended synaptotagmin-1
4468


P46013_C226
MKI67 Antigen KI-67
4469


P46013_C1373
MKI67 Antigen KI-67
4470


P46013_C1479
MKI67 Antigen KI-67
4471


P17858_C708
PFKL 6-phosphofructokinase, liver
4472



type


Q96PK6_C31
RBM14 RNA-binding protein 14
4473


P53602_C133
MVD Diphosphomevalonate
4474



decarboxylase


Q8WXH0_C1032
SYNE2 Nesprin-2
4475


Q14137_C108
BOP1 Ribosome biogenesis protein
4476



BOP1


P23368_C481
ME2 NAD-dependent malic enzyme,
4477



mitochondrial


P51692_C688
STAT5B Signal transducer and
4478



activator of transcription 5


Q8TD19_C890
NEK9 Serine/threonine-protein kinase
4479



Nek9


Q14008_C1113
CKAP5 Cytoskeleton-associated
4480



protein 5


Q14008_C1946
CKAP5 Cytoskeleton-associated
4481



protein 5


Q9UJU6_C67
DBNL Drebrin-like protein
4482


Q9UPQ0_C182
LIMCH1 LIM and calponin homology
4483



domains-containing protein


Q15424_C362
SAFB Scaffold attachment factor B1
4484


O95757_C290
HSPA4L Heat shock 70 kDa protein 4L
4485


P21333_C623
FLNA Filamin-A
4486


P51610_C326
HCFC1 Host cell factor 1
4487


Q9H6E5_C501
TUT1 Speckle targeted PIP5K1A-
4488



regulated poly(A) polymer


O00154_C100
ACOT7 Cytosolic acyl coenzyme A
4489



thioester hydrolase


O95347_C800
SMC2 Structural maintenance of
4490



chromosomes protein 2


Q96SZ5_C239
ADO 2-aminoethanethiol dioxygenase
4491


P18615_C297
RDBP Negative elongation factor E
4492


Q93034_C112
CUL5 Cullin-5
4493


O43913_C171
ORC5 Origin recognition complex
4494



subunit 5


P01033_C189
TIMP1 Metalloproteinase inhibitor 1
4495


Q92616_C1362
GCN1L1 Translational activator GCN1
4496


Q92616_C1781
GCN1L1 Translational activator GCN1
4497


Q99661_C154
KIF2C Kinesin-like protein KIF2C
4498


O60701_C196
UGDH UDP-glucose 6-dehydrogenase
4499


Q9UH65_C279
SWAP70 Switch-associated protein 70
4500


Q96FS4_C446
SIPA1 Signal-induced proliferation-
4501



associated protein 1


P49327_C1186
FASN Fatty acid synthase
4502


P49327_C1759
FASN Fatty acid synthase
4503


P49327_C2292
FASN Fatty acid synthase
4504


Q05655_C280
PRKCD Protein kinase C delta type
4505


Q05655_C344
PRKCD Protein kinase C delta type
4506


Q9BQE9_C189
BCL7B B-cell CLL/lymphoma 7
4507



protein family member B


Q8N1G0_C91
ZNF687 Zinc finger protein 687
4508


P13489_C45
RNH1 Ribonuclease inhibitor
4509


P48444_C479
ARCN1 Coatomer subunit delta
4510


Q96BN8_C129
FAM105B Protein FAM105B
4511


Q9UKU7_C159
ACAD8 Isobutyryl-CoA
4512



dehydrogenase, mitochondrial


Q9H2L5_C249
RASSF4 Ras association domain-
4513



containing protein 4


Q12888_0178
TP53BP1 Tumor suppressor p53-
4514



binding protein 1


P29034_C94
S100A2 Protein S100-A2
4515


Q9UQ35_C785
SRRM2 Serine/arginine repetitive
4516



matrix protein 2


O00329_C474
PIK3CD Phosphatidylinositol 4,5-
4517



bisphosphate 3-kinase catalytic


Q9Y2Y0_C149
ARL2BP ADP-ribosylation factor-like
4518



protein 2-binding protein


O15357_C1121
INPPL1 Phosphatidylinositol 3,4,5-
4519



trisphosphate 5-phosphatase 2


Q99832_C345
CCT7 T-complex protein 1 subunit eta
4520


Q9Y4D8_C1370
HECTD4 Probable E3 ubiquitin-protein
4521



ligase HECTD4


Q6KC79_C419
NIPBL Nipped-B-like protein
4522


P04179_C164
SOD2 Superoxide dismutase
4523


Q96RG2_C15
PASK PAS domain-containing
4524



serine/threonine-protein kinase


Q14061_C24
COX17 Cytochrome c oxidase copper
4525



chaperone


Q96DC7_C14
TMCO6 Transmembrane and coiled-
4526



coil domain-containing protein


P20248_C327
CCNA2 Cyclin-A2
4527


Q02878_C44
RPL6 60S ribosomal protein L6
4528


O14773_C365
TPP1 Tripeptidyl-peptidase 1
4529


P61086_C92
UBE2K Ubiquitin-conjugating enzyme
4530



E2 K


P31146_C332
CORO1A Coronin-1A
4531


Q9BR76_C153
CORO1B Coronin-1B
4532


Q96QC0_C463
PPP1R10 Serine/threonine-protein
4533



phosphatase 1 regulatory


Q5VT52_C1071
RPRD2 Regulation of nuclear pre-
4534



mRNA domain-containing p


P78527_C373
PRKDC DNA-dependent protein kinase
4535



catalytic subunit


Q96A35_C58
MRPL24 39S ribosomal protein L24,
4536



mitochondrial


Q14498_C303
RBM39 RNA-binding protein 39
4537


Q8N556_C157
AFAP1 Actin filament-associated
4538



protein 1


Q68CP9_C711
ARID2 AT-rich interactive domain-
4539



containing protein 2


Q9H3U1_C663
UNC45A Protein unc-45 homolog A
4540


Q99567_C595
NUP88 Nuclear pore complex protein
4541



Nup88


Q14789_C1713
GOLGB1 Golgin subfamily B member
4542



1


P20810_C661
CAST Calpastatin
4543


P07203_C115
GPX1 Glutathione peroxidase 1
4544


O60216_C35
RAD21 Double-strand-break repair
4545



protein rad21 homolog


O60216_C513
RAD21 Double-strand-break repair
4546



protein rad21 homolog


Q9ULV4_C190
CORO1C Coronin-1C
4547


P30153_C174
PPP2R1A Serine/threonine-protein
4548



phosphatase 2A 65 kDa regulatory



subunit A


P30153_C329
PPP2R1A Serine/threonine-protein
4549



phosphatase 2A 65 kDa regulatory



subunit A


Q9UEW8_C99
STK39 STE20/SPS1-related proline-
4550



alanine-rich protein kinase


Q13574_C265
DGKZ Diacylglycerol kinase zeta
4551


O00233_C216
PSMD9 26S proteasome non-ATPase
4552



regulatory subunit 9


P05023_C705
ATP1A1 Sodium/potassium-
4553



transporting ATPase subunit alpha


P45985_C266
MAP2K4 Dual specificity mitogen-
4554



activated protein kinase


P45983_C245
MAPK8 Mitogen-activated protein
4555



kinase 8


Q9P2R7_C320
SUCLA2 Succinyl-CoA ligase
4556


P31040_C89
SDHA Succinate dehydrogenase
4557


O76071_C234
CIAO1 Probable cytosolic iron-sulfur
4558



protein assembly protein CIAO1


O95372_C56
LYPLA2 Acyl-protein thioesterase 2
4559


Q04864_C524
REL Proto-oncogene c-Rel
4560


Q96CD2_C173
PPCDC Phosphopantothenoylcysteine
4561



decarboxylase


A6NC98_C1222
CCDC88B Coiled-coil domain-
4562



containing protein 88B


Q10570_C1020
CPSF1 Cleavage and polyadenylation
4563



specificity factor subunit 1


P43378_C506
PTPN9 Tyrosine-protein phosphatase
4564



non-receptor type 9


Q15021_C816
NCAPD2 Condensin complex subunit 1
4565


Q8TEW0_C6
PARD3 Partitioning defective 3
4566



homolog


O94925_C500
GLS Glutaminase kidney isoform,
4567



mitochondrial


Q9Y3B8_C137
REXO2 Oligoribonuclease,
4568



mitochondrial


Q96LD4_C347
TRIM47 Tripartite motif-containing
4569



protein 47


Q9H081_C104
MIS12 Protein MIS12 homolog
4570


P54687_C293
BCAT1 Branched-chain-amino-acid
4571



aminotransferase, cytosol


Q8WUM4_C524
PDCD6IP Programmed cell death 6-
4572



interacting protein


Q8WUM4_C691
PDCD6IP Programmed cell death 6-
4573



interacting protein


Q9H9A7_C366
RMI1 RecQ-mediated genome
4574



instability protein 1


Q13315_C2021
ATM Serine-protein kinase ATM
4575


P11766_C174
ADH5 Alcohol dehydrogenase class-3
4576


Q96EI5_C34
TCEAL4 Transcription elongation
4577



factor A protein-like 4


Q9NR45_C184
NANS Sialic acid synthase
4578


Q13542_C35
EIF4EBP2 Eukaryotic translation
4579



initiation factor 4E-binding


Q13547_C151
HDAC1 Histone deacetylase 1
4580


Q8NF50_C939
DOCK8 Dedicator of cytokinesis
4581



protein 8


P09110_C218
ACAA1 3-ketoacyl-CoA thiolase,
4582



peroxisomal


O60841_C749
EIF5B Eukaryotic translation initiation
4583



factor 5B


Q15306_C223
IRF4 Interferon regulatory factor 4
4584


Q96S59_C513
RANBP9 Ran-binding protein 9
4585


O60443_C180
DFNA5 Non-syndromic hearing
4586



impairment protein 5


P08240_C621
SRPR Signal recognition particle
4587



receptor subunit alpha


Q9NRR5_C29
UBQLN4 Ubiquilin-4
4588


Q92769_C274
HDAC2 Histone deacetylase 2
4589


O43823_C85
AKAP8 A-kinase anchor protein 8
4590


Q9Y3C7_C93
MED31 Mediator of RNA polymerase
4591



II transcription subunit


Q7Z7A3_C210
CTU1 Cytoplasmic tRNA 2-thiolation
4592



protein 1


Q14696_C180
MESDC2 LDLR chaperone MESD
4593


P19367_C628
HK1 Hexokinase-1
4594


Q13557_C373
CAMK2D Calcium/calmodulin-
4595



dependent protein kinase type I


Q9HB71_C154
CACYBP Calcyclin-binding protein
4596


O00148_C299
DDX39A ATP-dependent RNA
4597



helicase DDX39A


Q9BW19_C509
KIFC1 Kinesin-like protein KIFC1
4598


P48643_C440
CCT5 T-complex protein 1 subunit
4599



epsilon


Q03164_C2841
MLL Histone-lysine N-
4600



methyltransferase MLL


Q9H0L4_C441
CSTF2T Cleavage stimulation factor
4601



subunit 2 tau variant


P51553_C148
IDH3G Isocitrate dehydrogenase
4602


Q9Y678_C813
COPG1 Coatomer subunit gamma-1
4603


Q9UBB4_C405
ATXN10 Ataxin-10
4604


Q9C0C2_C1114
TNKS1BP1 182 kDa tankyrase-1-
4605



binding protein


Q9C0C2_C1175
TNKS1BP1 182 kDa tankyrase-1-
4606



binding protein


P09651_C43
HNRNPA1 Heterogeneous nuclear
4607



ribonucleoprotein A1


Q96R06_C307
SPAG5 Sperm-associated antigen 5
4608


Q8NFH8_C380
REPS2 RalBP1-associated Eps domain-
4609



containing protein 2


Q14204_C3325
DYNC1H1 Cytoplasmic dynein 1
4610



heavy chain 1


Q14204_C4121
DYNC1H1 Cytoplasmic dynein 1
4611



heavy chain 1


O75643_C502
SNRNP200 U5 small nuclear
4612



ribonucleoprotein 200 kDa helicas


O75643_C516
SNRNP200 U5 small nuclear
4613



ribonucleoprotein 200 kDa helicas


Q13085_C1297
ACACA Acetyl-CoA carboxylase 1
4614


P04049_C27
RAF1 RAF proto-oncogene
4615



serine/threonine-protein kinase


Q53T59_C287
HS1BP3 HCLS 1-binding protein 3
4616


P60468_C39
SEC61B Protein transport protein
4617



Sec61 subunit beta


Q15019_C114
SEPT2 Septin-2
4618


Q15643_C1299
TRIP11 Thyroid receptor-interacting
4619



protein 11


Q13541_C62
EIF4EBP1 Eukaryotic translation
4620



initiation factor 4E-binding


Q9HD42_C44
CHMP1A Charged multivesicular body
4621



protein 1a


O15371_C327
EIF3D Eukaryotic translation initiation
4622



factor 3 subunit


Q06187_C337
BTK Tyrosine-protein kinase BTK
4623


P55060_C344
CSE1L Exportin-2
4624


Q8IUD2_C1101
ERC1 ELKS/Rab6-interacting/CAST
4625



family member 1


Q9UBE0_C342
SAE1 SUMO-activating enzyme
4626



subunit 1


Q13459_C2028
MYO9B Unconventional myosin-IXb
4627


P41236_C86
PPP1R2 Protein phosphatase inhibitor 2
4628


Q6IA86_C746
ELP2 Elongator complex protein 2
4629


O75815_C449
BCAR3 Breast cancer anti-estrogen
4630



resistance protein 3


Q08J23_C599
NSUN2 tRNA (cytosine(34)-C(5))-
4631



methyltransferase


O15231_C466
ZNF185 Zinc finger protein 185
4632


Q8TF05_C566
PPP4R1 Serine/threonine-protein
4633



phosphatase 4 regulatory


Q86VQ1_C151
GLCCI1 Glucocorticoid-induced
4634



transcript 1 protein


Q66K14_C839
TBC1D9B TBC1 domain family
4635



member 9B


O75676_C257
RPS6KA4 Ribosomal protein S6 kinase
4636



alpha-4


Q01082_C2227
SPTBN1 Spectrin beta chain, non-
4637



erythrocytic 1


P61812_C89
TGFB2 Transforming growth factor
4638



beta-2


P42704_C927
LRPPRC Leucine-rich PPR motif-
4639



containing protein, mitochondrial


Q02218_C604
OGDH 2-oxoglutarate dehydrogenase,
4640



mitochondrial


Q99594_C368
TEAD3 Transcriptional enhancer factor
4641



TEF-5


P42858_C1961
HTT Huntingtin
4642


P42858_C2971
HTT Huntingtin
4643


P82675_C211
MRPS5 28S ribosomal protein S5,
4644



mitochondrial


P21291_C25
CSRP1 Cysteine and glycine-rich
4645



protein 1


O43447_C131
PPIH Peptidyl-prolyl cis-trans
4646



isomerase H


Q9UBR2_C132
CTSZ Cathepsin Z
4647


P31939_C101
ATIC Bifunctional purine biosynthesis
4648



protein PURH


Q9P2E9_C1128
RRBP1 Ribosome-binding protein 1
4649


Q9NWU1_C209
OXSM 3-oxoacyl-ACP synthase,
4650



mitochondrial


O95059_C78
RPP14 Ribonuclease P protein subunit
4651



p14


P51570_C322
GALK1 Galactokinase
4652


P28340_C1076
POLD1 DNA polymerase delta
4653



catalytic subunit


Q7Z5L9_C555
IRF2BP2 Interferon regulatory factor 2-
4654



binding protein 2


P54886_C161
ALDH18A1 Delta-1-pyrroline-5-
4655



carboxylate synthase


P17987_C236
TCP1 T-complex protein 1 subunit
4656



alpha


O43143_C774
DHX15 Putative pre-mRNA-splicing
4657



factor ATP-dependent RN


P67775_C251
PPP2CA Serine/threonine-protein
4658



phosphatase 2A catalytic


Q92667_C102
AKAP1 A-kinase anchor protein 1,
4659



mitochondrial


Q99615_C116
DNAJC7 DnaJ homolog subfamily C
4660



member 7


P04062_C165
GBA Glucosylceramidase
4661


Q96P11_C308
NSUN5 Putative methyltransferase
4662



NSUN5


Q86X02_C160
CDR2L Cerebellar degeneration-related
4663



protein 2-like


P16035_C159
TIMP2 Metalloproteinase inhibitor 2
4664


Q52LW3_C793
ARHGAP29 Rho GTPase-activating
4665



protein 29


H3BQZ7_C538
Uncharacterized protein
4666


Q9BQ90_C213
KLHDC3 Kelch domain-containing
4667



protein 3


P13797_C167
PLS3 Plastin-3
4668


Q06210_C620
GFPT1 Glucosamine--fructose-6-
4669



phosphate aminotransferase


Q7L576_C98
CYFIP1 Cytoplasmic FMR1-interacting
4670



protein 1


Q7L576_C1241
CYFIP1 Cytoplasmic FMRI-interacting
4671



protein 1


Q03001_C5056
DST Dystonin
4672


Q03001_C5394
DST Dystonin
4673


Q9UFW8_C92
CGGBP1 CGG triplet repeat-binding
4674



protein 1


P49721_C163
PSMB2 Proteasome subunit beta type-2
4675


Q96I51_C329
WBSCR16 Williams-Beuren syndrome
4676



chromosomal region 16 protein


O60884_C280
DNAJA2 DnaJ homolog subfamily A
4677



member 2


O60884_C308
DNAJA2 DnaJ homolog subfamily A
4678



member 2


Q9BV19_C189
C1orf50 Uncharacterized protein
4679



C1orf50


P29353_C248
SHC1 SHC-transforming protein 1
4680


Q7Z4Q2_C57
HEATR3 HEAT repeat-containing
4681



protein 3


O75376_C2403
NCOR1 Nuclear receptor corepressor 1
4682


Q9Y6A5_C293
TACC3 Transforming acidic coiled-
4683



coil-containing protein


P31323_C149
PRKAR2B cAMP-dependent protein
4684



kinase type II-beta regulatory subunit



beta


Q15120_C41
PDK3
4685


P05455_C18
SSB Lupus La protein
4686


Q08257_C166
CRYZ Quinone oxidoreductase
4687


P54278_C216
PMS2 Mismatch repair endonuclease
4688



PMS2


P05534_C363
HLA-A HLA class I histocompatibility
4689



antigen, A-24 alpha


Q96P16_C100
RPRD1A Regulation of nuclear pre-
4690



mRNA domain-containing protein


Q9NWK9_C211
ZNHIT6 Box C/D snoRNA protein 1
4691


Q9BZF9_C408
UACA Uveal autoantigen with coiled-
4692



coil domains and ankyrin repeats


P57081_C412
WDR4 tRNA (guanine-N(7)-)-
4693



methyltransferase subunit WDR


Q9H4L7_C861
SMARCAD1 SWI/SNF-related matrix-
4694



associated actin-dependent


Q14149_C671
MORC3 MORC family CW-type zinc
4695



finger protein 3


Q8WUA7_C151
TBC1D22A TBC1 domain family
4696



member 22A


Q2T9J0_C284
TYSND1 Peroxisomal leader peptide-
4697



processing protease


Q96C86_C37
DCPS m7GpppX diphosphatase
4698


P30084_C143
ECHS1 Enoyl-CoA hydratase,
4699



mitochondrial


Q29RF7_C1093
PDS5A Sister chromatid cohesion
4700



protein PDS5 homolog A


O15111_C30
CHUK Inhibitor of nuclear factor
4701



kappa-B kinase subunit


Q9H7B4_C238
SMYD3 SET and MYND domain-
4702



containing protein 3


Q8TDX7_C53
NEK7 Serine/threonine-protein kinase
4703



Nek7


Q8TDX7_C298
NEK7 Serine/threonine-protein kinase
4704



Nek7


Q86W56_C155
PARG Poly(ADP-ribose)
4705



glycohydrolase


P43246_C199
MSH2 DNA mismatch repair protein
4706



Msh2


P28702_C340
RXRB Retinoic acid receptor RXR-beta
4707


Q13283_C73
G3BP1 Ras GTPase-activating protein-
4708



binding protein 1


O75608_C173
LYPLA1 Acyl-protein thioesterase 1
4709


P23497_C248
SP100 Nuclear autoantigen Sp-100
4710


Q8WX92_C115
COBRA1 Negative elongation factor B
4711


O75044_C820
SRGAP2 SLIT-ROBO Rho GTPase-
4712



activating protein 2


Q13464_C1206
ROCK1 Rho-associated protein kinase
4713



1


O96013_C58
PAK4 Serine/threonine-protein kinase
4714



PAK 4


P15056_C748
BRAF Serine/threonine-protein kinase
4715



B-raf


Q16762_C248
TST Thiosulfate sulfurtransferase
4716


P05198_C218
EIF2S1 Eukaryotic translation initiation
4717



factor 2 subunit


P15374_C209
UCHL3 Ubiquitin carboxyl-terminal
4718



hydrolase isozyme L3


Q9NZN4_C356
EHD2 EH domain-containing protein 2
4719


Q9NZN8_C175
CNOT2 CCR4-NOT transcription
4720



complex subunit 2


P52294_C529
KPNA1 Importin subunit alpha-1
4721


O76003_C46
GLRX3 Glutaredoxin-3
4722


P35914_C307
HMGCL Hydroxymethylglutaryl-CoA
4723



lyase, mitochondrial


Q00796_C179
SORD Sorbitol dehydrogenase
4724


P27797_C105
CALR Calreticulin
4725


Q969E4_C44
TCEAL3 Transcription elongation
4726



factor A protein-like 3


Q7KZF4_C152
SND1 Staphylococcal nuclease domain-
4727



containing protein


Q9P1U0_C78
ZNRD1 DNA-directed RNA
4728



polymerase I subunit RPA12


Q8WZ82_C152
OVCA2 Ovarian cancer-associated
4729



gene 2 protein


Q9NPD3——C97
EXOSC4 Exosome complex component
4730



RRP41


P52701_C1294
MSH6 DNA mismatch repair protein
4731



Msh6


P52701_C1337
MSH6 DNA mismatch repair protein
4732



Msh6


Q15637_C279
SF1 Splicing factor 1
4733


P49366_C177
DHPS Deoxyhypusine synthase
4734


Q96PQ7_C677
KLHL5 Kelch-like protein 5
4735


O95785_C1429
WIZ Protein Wiz
4736


P49756_C795
RBM25 RNA-binding protein 25
4737


P49591_C398
SARS Serine--tRNA ligase,
4738



cytoplasmic


P31751_C77
AKT2 RAC-beta serine/threonine-
4739



protein kinase


Q9Y2X3_C205
NOP58 Nucleolar protein 58
4740


Q8IZ21_C568
PHACTR4 Phosphatase and actin
4741



regulator 4


O00410_C266
IPO5 Importin-5
4742


O95861_C249
BPNT1 3(2),5-bisphosphate
4743



nucleotidase 1


Q9NTK5_C7S
OLA1 Obg-like ATPase 1
4744


P60228_C141
EIF3E Eukaryotic translation initiation
4745



factor 3 subunit


Q05048_C44
CSTF1 Cleavage stimulation factor
4746



subunit 1


P41229_C1551
KDM5C Lysine-specific demethylase
4747



5C


Q9NZ09_C161
UBAP1 Ubiquitin-associated protein 1
4748


Q9H4A4_C151
RNPEP Aminopeptidase B
4749


Q99704_C308
DOK1 Docking protein 1
4750


Q16531_C128
DDB1 DNA damage-binding protein 1
4751


O43294_C91
TGFB1I1 Transforming growth factor
4752



beta-1-induced transcript 1


P28482_C65
MAPK1 Mitogen-activated protein
4753



kinase 1


P36578_C250
RPL4 60S ribosomal protein L4
4754


Q9Y5N6_C88
ORC6 Origin recognition complex
4755



subunit 6


P62487_C106
POLR2G DNA-directed RNA
4756



polymerase II subunit RPB7


O00139_C406
KIF2A Kinesin-like protein KIF2A
4757


P21266_C119
GSTM3 Glutathione S-transferase Mu 3
4758


O00622_C78
CYR61 Protein CYR61
4759


O00622_C117
CYR61 Protein CYR61
4760


O00622_C353
CYR61 Protein CYR61
4761


Q86WA6_C234
BPHL Valacyclovir hydrolase
4762


Q9BUF5_C354
TUBB6 Tubulin beta-6 chain
4763


Q07960_C91
ARHGAP1 Rho GTPase-activating
4764



protein 1


P78346_C257
RPP30 Ribonuclease P protein subunit
4765



p30


P16885_C849
PLCG2 1-phosphatidylinositol 4,5-
4766



bisphosphate phosphodiese


Q969U7_C168
PSMG2 Proteasome assembly
4767



chaperone 2


Q9BZG1_C38
RAB34 Ras-related protein Rab-34
4768


Q96KQ7_C596
EHMT2 Histone-lysine N-
4769



methyltransferase EHMT2


Q8IWB7_C401
WDFY1 WD repeat and FYVE
4770



domain-containing protein 1


Q14566_C721
MCM6 DNA replication licensing
4771



factor MCM6


P17844_C170
DDX5 Probable ATP-dependent RNA
4772



helicase DDX5


O94903_C261
PROSC Proline synthase co-transcribed
4773



bacterial homolog


Q9UPN3_C5346
MACF1 Microtubule-actin cross-
4774



linking factor 1, isoforms


P53634_C355
CTSC Dipeptidyl peptidase 1
4775


Q5VZL5_C948
ZMYM4 Zinc finger MYM-type
4776



protein 4


A5YKK6_C2359
CNOT1 CCR4-NOT transcription
4777



complex subunit 1


Q9BWU0_C336
SLC4A1AP Kanadaptin
4778


O75369_C1868
FLNB Filamin-B
4779


O75369_C1876
FLNB Filamin-B
4780


P21980_C620
TGM2 Protein-glutamine gamma-
4781



glutamyltransferase 2


Q14966_C1279
ZNF638 Zinc finger protein 638
4782


P50395_C335
GDI2 Rab GDP dissociation inhibitor
4783



beta


Q13643_C150
FHL3 Four and a half LIM domains
4784



protein 3


Q16181_C161
SEPT7 Septin-7
4785


Q9UPR0_C90
PLCL2 Inactive phospholipase C-like
4786



protein 2


Q9UPR0_C1095
PLCL2 Inactive phospholipase C-like
4787



protein 2


O14787_C132
TNPO2 Transportin-2
4788


O15067_C1338
PFAS
4789



Phosphoribosylformylglycinamidine



synthase


Q9NW64_C58
RBM22 Pre-mRNA-splicing factor
4790



RBM22


O00273_C21
DFFA DNA fragmentation factor
4791



subunit alpha


Q86V21_C493
AACS Acetoacetyl-CoA synthetase
4792


Q96GX5_C251
MASTL Serine/threonine-protein
4793



kinase greatwall


Q96GX5_C614
MASTL Serine/threonine-protein
4794



kinase greatwall


O60493_C140
SNX3 Sorting nexin-3
4795


P29279_C120
CTGF Connective tissue growth factor
4796


P49790_C585
NUP153 Nuclear pore complex protein
4797



Nup153


P49790_C753
NUP153 Nuclear pore complex protein
4798



Nup153


P51114_C99
FXR1 Fragile X mental retardation
4799



syndrome-related protein


Q15170_C88
TCEAL1 Transcription elongation
4800



factor A protein-like 1


Q8IY18_C229
SMC5 Structural maintenance of
4801



chromosomes protein 5


P62979_C126
RPS27A Ubiquitin-40S ribosomal
4802



protein S27a


Q9BSJ8_C635
ESYT1 Extended synaptotagmin-1
4803


P35658_C399
NUP214 Nuclear pore complex protein
4804



Nup214


P27694_C200
RPA1 Replication protein A 70 kDa
4805



DNA-binding subunit


P27694_C503
RPA1 Replication protein A 70 kDa
4806



DNA-binding subunit


P46013_C1843
MKI67 Antigen KI-67
4807


P17858_C212
PFKL 6-phosphofructokinase, liver
4808



type


Q14353_C220
GAMT Guanidinoacetate N-
4809



methyltransferase


Q7Z5J4_C239
RAI1 Retinoic acid-induced protein 1
4810


O75083_C438
WDR1 WD repeat-containing protein 1
4811


Q8WXH0_C553
SYNE2 Nesprin-2
4812


Q14137_C469
BOP1 Ribosome biogenesis protein
4813



BOP1


Q8N4X5_C781
AFAP1L2 Actin filament-associated
4814



protein 1-like 2


P52732_C773
KIF11 Kinesin-like protein KIF11
4815


Q7Z6Z7_C1879
HUWE1 E3 ubiquitin-protein ligase
4816



HUWE1


Q7Z6Z7_C4099
HUWE1 E3 ubiquitin-protein ligase
4817



HUWE1


P11216_C496
PYGB Glycogen phosphorylase, brain
4818



form


Q16514_C143
TAF12 Transcription initiation factor
4819



TFIID subunit 12


Q9H3P2_C471
WHSC2 Negative elongation factor A
4820


Q9UFC0_C88
LRWD1 Leucine-rich repeat and WD
4821



repeat-containing protein


Q9UFC0_C249
LRWD1 Leucine-rich repeat and WD
4822



repeat-containing prote


Q96RR4_C223
CAMKK2 Calcium/calmodulin-
4823



dependent protein kinase kinase


Q9UJU6_C97
DBNL Drebrin-like protein
4824


Q9NYZ3_C45
GTSE1 G2 and S phase-expressed
4825



protein 1


Q9ULI3_C1360
HEG1 Protein HEG homolog 1
4826


P38606_C277
ATP6V1A V-type proton ATPase
4827



catalytic subunit A


Q9UPQ0_C333
LIMCH1 LIM and calponin homology
4828



domains-containing protein


Q7L2H7_C125
EIF3M Eukaryotic translation initiation
4829



factor 3 subunit


Q9BPX3_C177
NCAPG Condensin complex subunit 3
4830


O95757_C540
HSPA4L Heat shock 70 kDa protein 4L
4831


O95757_C589
HSPA4L Heat shock 70 kDa protein 4L
4832


Q9BWH6_C195
RPAP1 RNA polymerase Il-associated
4833



protein 1


Q8NHV4_C314
NEDD1 Protein NEDD1
4834


Q9UJV9_C568
DDX41 Probable ATP-dependent RNA
4835



helicase DDX41


P13010_C157
XRCC5 X-ray repair cross-
4836



complementing protein 5


O95340_C202
PAPSS2 Bifunctional 3-
4837



phosphoadenosine 5-phosphosulfate


Q5JZ73_C9
LINC00207 Protein LINC00207
4838


Q6DN90_C214
IQSEC1 IQ motif and SEC7 domain-
4839



containing protein 1


Q9BZE9_C127
ASPSCR1 Tether containing UBX
4840



domain for GLUT4


O95294_C386
RASAL1 RasGAP-activating-like
4841



protein 1


O95294_C534
RASAL1 RasGAP-activating-like
4842



protein 1


P06737_C496
PYGL Glycogen phosphorylase, liver
4843



form


Q92616_C1482
GCN1L1 Translational activator GCN1
4844


Q9Y6I9_C165
TEX264 Testis-expressed sequence 264
4845



protein


Q99996_C1966
AKAP9 A-kinase anchor protein 9
4846


Q6UB99_C2640
ANKRD11 Ankyrin repeat domain-
4847



containing protein 11


Q9NRV9_C168
HEBP1 Heme-binding protein 1
4848


Q6ZUT6_C437
C15orf52 Uncharacterized protein
4849



C15orf52


P15407_C172
FOSL1 Fos-related antigen 1
4850


Q9BYG3_C237
MKI67IP MKI67 FHA domain-
4851



interacting nucleolar phosphoprotein


P49327_C496
FASN Fatty acid synthase
4852


Q99436_C74
PSMB7 Proteasome subunit beta type-7
4853


Q96BR1_C308
SGK3 Serine/threonine-protein kinase
4854



Sgk3


Q9GZS1_C200
POLR1E DNA-directed RNA
4855



polymerase I subunit RPA49


P41091_C269
EIF2S3 Eukaryotic translation initiation
4856



factor 2 subunit


Q12769_C659
NUP160 Nuclear pore complex protein
4857



Nup160


P13489_C313
RNH1 Ribonuclease inhibitor
4858


Q9H5N1_C482
RABEP2 Rab GTPase-binding effector
4859



protein 2


Q9Y2Z0_C49
SUGT1 Suppressor of G2 allele of
4860



SKP1 homolog


P48444_C441
ARCN1 Coatomer subunit delta
4861


Q12888_C1375
TP53BP1 Tumor suppressor p53-
4862



binding protein 1


P14921_C112
ETS1 Protein C-ets-1
4863


Q5JTZ9_C443
AARS2 Alanine--tRNA ligase,
4864



mitochondrial


Q92990_C406
GLMN Glomulin
4865


Q9P0J1_C132
PDP1
4866


Q8NBJ5_C369
GLT25D1 Procollagen
4867



galactosyltransferase 1


P01591_C94
IGJ Immunoglobulin J chain
4868


Q96QR8_C238
PURB Transcriptional activator protein
4869



Pur-beta


Q99832_C326
CCT7 T-complex protein 1 subunit eta
4870


O95218_C71
ZRANB2 Zinc finger Ran-binding
4871



domain-containing protein


O43237_C191
DYNC1LI2 Cytoplasmic dynein 1 light
4872



intermediate chain 2


Q92576_C276
PHF3 PHD finger protein 3
4873


Q9HAU0_C473
PLEKHA5 Pleckstrin homology
4874



domain-containing family A member


O95425_C76
SVIL Supervillin
4875


Q8TD30_C158
GPT2 Alanine aminotransferase 2
4876


Q8TD30_C347
GPT2 Alanine aminotransferase 2
4877


Q14790_C409
CASP8 Caspase-8
4878


P09211_C170
GSTP1 Glutathione S-transferase P
4879


Q03519_C641
TAP2 Antigen peptide transporter 2
4880


Q9ULW0_C462
TPX2 Targeting protein for Xklp2
4881


Q16222_C251
UAP1 UDP-N-acetylhexosamine
4882



pyrophosphorylase


P61158_C408
ACTR3 Actin-related protein 3
4883


Q6WKZ4_C318
RAB11FIP1 Rab11 family-interacting
4884



protein 1


Q9HCE7_C725
SMURF1 E3 ubiquitin-protein ligase
4885



SMURF1


Q13564_C153
NAE1 NEDD8-activating enzyme E1
4886



regulatory subunit


Q13564_C384
NAE1 NEDD8-activating enzyme E1
4887



regulatory subunit


P31146_C24
CORO1A Coronin-1A
4888


Q96JM7_C169
L3MBTL3 Lethal(3)malignant brain
4889



tumor-like protein 3


P07199_C135
CENPB Major centromere autoantigen
4890



B


O00442_C28
RTCA RNA 3-terminal phosphate
4891



cyclase


P13639_C388
EEF2 Elongation factor 2
4892


Q9P0K7_C468
RAI14 Ankycorbin
4893


P35606_C276
COPB2 Coatomer subunit beta
4894


P46199_C290
MTIF2 Translation initiation factor IF-
4895



2, mitochondrial


P78527_C232
PRKDC DNA-dependent protein kinase
4896



catalytic subunit


P78527_C1455
PRKDC DNA-dependent protein kinase
4897



catalytic subunit


P78527_C4045
PRKDC DNA-dependent protein kinase
4898



catalytic subunit


P11908_C60
PRPS2 Ribose-phosphate
4899



pyrophosphokinase 2


Q9H410_C65
DSN1 Kinetochore-associated protein
4900



DSN1 homolog


Q14498_C478
RBM39 RNA-binding protein 39
4901


O75694_C1344
NUP155 Nuclear pore complex protein
4902



Nup155


Q8WU76_C79
SCFD2 Sec1 family domain-containing
4903



protein 2


Q8IU81_C207
IRF2BP1 Interferon regulatory factor 2-
4904



binding protein 1


P49189_C443
ALDH9A1 4-
4905



trimethylaminobutyraldehyde



dehydrogenase


Q14789_C1257
GOLGB1 Golgin subfamily B member
4906



1


Q8N5K1_C92
CISD2 CDGSH iron-sulfur domain-
4907



containing protein 2


O43592_C693
XPOT Exportin-T
4908


O43374_C302
RASA4 Ras GTPase-activating protein
4909



4


O43374_C657
RASA4 Ras GTPase-activating protein
4910



4


Q9NUQ3_C480
TXLNG Gamma-taxilin
4911


P63104_C189
YWHAZ 14-3-3 protein zeta/delta
4912


O60216_C392
RAD21 Double-strand-break repair
4913



protein rad21 homolog


Q8N3U4_C869
STAG2 Cohesin subunit SA-2
4914


Q9ULV4_C283
CORO1C Coronin-1C
4915


P61160_C221
ACTR2 Actin-related protein 2
4916


Q12904_C161
AIMP1 Aminoacyl tRNA synthase
4917



complex-interacting multifunctional



protein 1


Q9H9P8_C187
L2HGDH L-2-hydroxyglutarate
4918



dehydrogenase, mitochondrial


Q7Z2W4_C272
ZC3HAV1 Zinc finger CCCH-type
4919



antiviral protein 1


P30153_C148
PPP2R1A Serine/threonine-protein
4920



phosphatase 2A 65 kDa regulatory



subunit A alpha isoform


Q92797_C969
SYMPK Symplekin
4921


Q9Y3B7_C50
MRPL11 39S ribosomal protein L11,
4922



mitochondrial


Q9BV44_C391
THUMPD3 THUMP domain-
4923



containing protein 3


O14578_C402
CIT Citron Rho-interacting kinase
4924


Q9NVU0_C70
POLR3E DNA-directed RNA
4925



polymerase III subunit RPC5


Q92947_C115
GCDH Glutaryl-CoA dehydrogenase,
4926



mitochondrial


Q6PJ69_C320
TRIM65 Tripartite motif-containing
4927



protein 65


Q15027_C501
ACAP1 Arf-GAP with coiled-coil,
4928



ANK repeat and PH domain


Q15020_C341
SART3 Squamous cell carcinoma
4929



antigen recognized by T-cells 3


Q9Y6J9_C41
TAF6L TAF6-like RNA polymerase II
4930



p300/CBP-associated factor 6 like


P17812_C216
CTPS1 CTP synthase 1
4931


Q96GG9_C29
DCUN1D1 DCN1-like protein 1
4932


Q14315_C1448
FLNC Filamin-C
4933


Q9NSP4_C40
CENPM Centromere protein M
4934


Q9Y3B2_C40
EXOSC1 Exosome complex component
4935



CSL4


Q9H4K7_C206
GTPBP5 GTP-binding protein 5
4936


P62140_C201
PPP1CB Serine/threonine-protein
4937



phosphatase PP1-beta catalytic subunit


Q9H063_C133
MAF1 Repressor of RNA polymerase
4938



III transcription MAF1


P23434_C138
GCSH Glycine cleavage system H
4939



protein, mitochondrial


Q5JPH6_C386
EARS2 Probable glutamate--tRNA
4940



ligase, mitochondrial


O14976_C1142
GAK Cyclin-G-associated kinase
4941


O14974_C553
PPP1R12A Protein phosphatase 1
4942



regulatory subunit 12A


Q9H9A6_C438
LRRC40 Leucine-rich repeat-
4943



containing protein 40


Q13315_C2607
ATM Serine-protein kinase ATM
4944


P51116_C270
FXR2 Fragile X mental retardation
4945



syndrome-related protein


Q8N3X1_C877
FNBP4 Formin-binding protein 4
4946


P36404_C153
ARL2 ADP-ribosylation factor-like
4947



protein 2


Q9HD64_C43
XAGE1E G antigen family D member
4948



2


Q8NF50_C1230
DOCK8 Dedicator of cytokinesis
4949



protein 8


Q8WWM7_C628
ATXN2L Ataxin-2-like protein
4950


P55795_C290
HNRNPH2 Heterogeneous nuclear
4951



ribonucleoprotein H2


Q9BYW2_C1471
SETD2 Histone-lysine N-
4952



methyltransferase SETD2


O15143_C202
ARPC1B Actin-related protein 2/3
4953



complex subunit 1B


O15294_C323
OGT UDP-N-acetylglucosamine--
4954



peptide N-acetylglucosamine (GlcNAc)



transferase


Q92945_C176
KHSRP Far upstream element-binding
4955



protein 2


O43847_C60
NRD1 Nardilysin
4956


Q9H9A5_C504
CNOT10 CCR4-NOT transcription
4957



complex subunit 10


Q9H9A5_C633
CNOT10 CCR4-NOT transcription
4958



complex subunit 10


P10155_C71
TROVE2 60 kDa SS-A/Ro
4959



ribonucleoprotein


P52789_C386
HK2 Hexokinase-2
4960


Q01469_C43
FABP5 Fatty acid-binding protein,
4961



epidermal


P46734_C305
MAP2K3 Dual specificity mitogen-
4962



activated protein kinase


P35579_C511
MYH9 Myosin-9
4963


P35579_C789
MYH9 Myosin-9
4964


Q9Y3C1_C36
NOP16 Nucleolar protein 16
4965


P62888_C52
RPL30 60S ribosomal protein L30
4966


Q8TAQ2_C495
SMARCC2 SWI/SNF complex subunit
4967



SMARCC2


O94854_C242
KIAA0754 Uncharacterized protein
4968



KIAA0754


P23526_C113
AHCY Adenosylhomocysteinase
4969


Q6QNY1_C41
BLOC1S2 Biogenesis of lysosome-
4970



related organelles complex


Q7Z7A4_C196
PXK PX domain-containing protein
4971



kinase-like protein


Q14699_C128
RFTN1 Raftlin
4972


Q14694_C254
USP10 Ubiquitin carboxyl-terminal
4973



hydrolase 10


Q13435_C661
SF3B2 Splicing factor 3B subunit 2
4974


P22692_C38
IGFBP4 Insulin-like growth factor-
4975



binding protein 4


P22692_C215
IGFBP4 Insulin-like growth factor-
4976



binding protein 4


P60900_C161
PSMA6 Proteasome subunit alpha type-
4977



6


Q9NWY4_C17
C4orf27 UPF0609 protein C4orf27
4978


P12004_C62
PCNA Proliferating cell nuclear antigen
4979


O00148_C238
DDX39A ATP-dependent RNA
4980



helicase DDX39A


Q9BW19_C144
KIFC1 Kinesin-like protein KIFC1
4981


Q9BW19_C557
KIFC1 Kinesin-like protein KIFC1
4982


Q15477_C247
SKIV2L Helicase SKI2W
4983


Q9NQ89_C9
C12orf4 Uncharacterized protein
4984



C12orf4


Q9Y2R9_C152
MRPS7 28S ribosomal protein S7,
4985



mitochondrial


Q12933_C287
TRAF2 TNF receptor-associated factor
4986



2


Q12931_C501
TRAP1 Heat shock protein 75 kDa,
4987



mitochondrial


Q9NQS1_C251
AVEN Cell death regulator Aven
4988


Q9UBB4_C134
ATXN10 Ataxin-10
4989


Q9UBB4_C382
ATXN10 Ataxin-10
4990


Q9C0C9_C910
UBE2O Ubiquitin-conjugating enzyme
4991



E2 O


Q9BTW9_C234
TBCD Tubulin-specific chaperone D
4992


Q9Y520_C2340
PRRC2C Protein PRRC2C
4993


O75533_C933
SF3B1 Splicing factor 3B subunit 1
4994


O75533_C1059
SF3B1 Splicing factor 3B subunit 1
4995


Q96BD8_C29
SKA1 Spindle and kinetochore-
4996



associated protein 1


Q14192_C28
FHL2 Four and a half LIM domains
4997



protein 2


Q14192_C129
FHL2 Four and a half LIM domains
4998



protein 2


Q92844_C328
TANK TRAF family member-
4999



associated NF-kappa-B activator


Q9Y4H4_C116
GPSM3 G-protein-signaling modulator
5000



3


P30154_C389
PPP2R1B Serine/threonine-protein
5001



phosphatase 2A 65 kDa regulatory



subunit A beta


Q9UN37_C403
VPS4A Vacuolar protein sorting-
5002



associated protein 4A


Q96RL1_C121
UIMC1 BRCA1-A complex subunit
5003



RAP80


Q8WZA9_C443
IRGQ Immunity-related GTPase family
5004



Q protein


Q8IZT6_C51
ASPM Abnormal spindle-like
5005



microcephaly-associated protein


P11586_C408
MTHFD1 C-1-tetrahydrofolate
5006



synthase, cytoplasmic


P11586_C691
MTHFD1 C-1-tetrahydrofolate
5007



synthase, cytoplasmic


P11586_C785
MTHFD1 C-1-tetrahydrofolate
5008



synthase, cytoplasmic


P21912_C243
SDHB Succinate dehydrogenase
5009


Q99471_C49
PFDN5 Prefoldin subunit 5
5010


P48735_C336
IDH2 Isocitrate dehydrogenase
5011


Q9UJM3_C430
ERRFI1 ERBB receptor feedback
5012



inhibitor 1


Q6IA69_C627
NADSYN1 Glutamine-dependent
5013



NAD(+) synthetase


P61221_C201
ABCE1 ATP-binding cassette sub-
5014



family E member 1


Q7L1V2_C326
MON1B Vacuolar fusion protein
5015



MON1 homolog B


Q7L1V2_C349
MON1B Vacuolar fusion protein
5016



MON1 homolog B


P62136_C202
PPP1CA Serine/threonine-protein
5017



phosphatase PP1-alpha catalytic subunit


Q8IWS0_C87
PHF6 PHD finger protein 6
5018


O95239_C1159
KIF4A Chromosome-associated kinesin
5019



KIF4A


P05091_C66
ALDH2 Aldehyde dehydrogenase,
5020



mitochondrial


O75817_C66
POP7 Ribonuclease P protein subunit
5021



p20


O15231_C650
ZNF185 Zinc finger protein 185
5022


Q92922_C520
SMARCC1 SWI/SNF complex subunit
5023



SMARCC1


Q9NSY1_C32
BMP2K BMP-2-inducible protein
5024



kinase


O60671_C148
RAD1 Cell cycle checkpoint protein
5025



RAD1


O75676_C425
RPS6KA4 Ribosomal protein S6 kinase
5026



alpha-4


Q01082_C964
SPTBN1 Spectrin beta chain, non-
5027



erythrocytic 1


P61812_C380
TGFB2 Transforming growth factor
5028



beta-2


P42704_C361
LRPPRC Leucine-rich PPR motif-
5029



containing protein, mitochondrial


P42858_C777
HTT Huntingtin
5030


P42858_C1808
HTT Huntingtin
5031


P34932_C146
HSPA4 Heat shock 70 kDa protein 4
5032


P34932_C167
HSPA4 Heat shock 70 kDa protein 4
5033


O43447_C174
PPIH Peptidyl-prolyl cis-trans
5034



isomerase H


P31937_C75
HIBADH 3-hydroxyisobutyrate
5035



dehydrogenase, mitochondrial


P31937_C199
HIBADH 3-hydroxyisobutyrate
5036



dehydrogenase, mitochondrial


Q8IXK0_C740
PHC2 Polyhomeotic-like protein 2
5037


Q9NUI1_C120
DECR2 Peroxisomal 2,4-dienoyl-CoA
5038



reductase


Q9NR50_C334
EEF2B3 Translation initiation factor
5039



eIF-2B subunit gamma


Q9NV56_C59
MRGBP MRG-binding protein
5040


Q9BYV9_C340
BACH2 Transcription regulator protein
5041



BACH2


P08237_C351
PFKM 6-phosphofructokinase, muscle
5042



type


Q15118_C240
PDK1
5043


Q5M775_C805
SPECC1 Cytospin-B
5044


Q9H845_C507
ACAD9 Acyl-CoA dehydrogenase
5045



family member 9, mitochondrial


Q8TF72_C1983
SHROOM3 Protein Shroom3
5046


Q7Z5L9_C521
IRF2BP2 Interferon regulatory factor 2-
5047



binding protein 2


Q86VP6_C237
CAND1 Cullin-associated NEDD8-
5048



dissociated protein 1


O43148_C95
RNMT mRNA cap guanine-N7
5049



methyltransferase


P27144_C104
AK4 Adenylate kinase isoenzyme 4,
5050



mitochondrial


P67775_C269
PPP2CA Serine/threonine-protein
5051



phosphatase 2A catalytic


Q92667_C438
AKAP1 A-kinase anchor protein 1,
5052



mitochondrial


Q9NYL2_C285
MLTK Mitogen-activated protein
5053



kinase kinase kinase MLT


Q9Y5X2_C455
SNX8 Sorting nexin-8
5054


Q14152_C185
EIF3A Eukaryotic translation initiation
5055



factor 3 subunit


Q15669_C108
RHOH Rho-related GTP-binding
5056



protein RhoH


P19623_C89
SRM Spermidine synthase
5057


P63244_C153
GNB2L1 Guanine nucleotide-binding
5058



protein subunit beta-2-like 1


Q9NZB2_C892
FAM120A Constitutive coactivator of
5059



PPAR-gamma-like protein


Q15398_C696
DLGAP5 Disks large-associated protein
5060



5


O60566_C51
BUB1B Mitotic checkpoint
5061



serine/threonine-protein kinase


Q9UDY4_C175
DNAJB4 DnaJ homolog subfamily B
5062



member 4


Q03001_C6799
DST Dystonin
5063


P11182_C279
DBT Lipoamide acyltransferase
5064



component of branched-chain



transacylase E2


P56537_C110
EIF6 Eukaryotic translation initiation
5065



factor 6


O15037_C157
KHNYN Protein KHNYN
5066


Q15052_C57
ARHGEF6 Rho guanine nucleotide
5067



exchange factor 6


Q15052_C553
ARHGEF6 Rho guanine nucleotide
5068



exchange factor 6


O00592_C381
PODXL Podocalyxin
5069


E7EVH7_C408
KLC1 Kinesin light chain 1
5070


E7EVH7_C628
KLC1 Kinesin light chain 1
5071


Q9H2U2_C161
PPA2 Inorganic pyrophosphatase 2,
5072



mitochondrial


P24390_C29
KDELR1 ER lumen protein retaining
5073



receptor 1


Q9H0W9_C149
C11orf54 Ester hydrolase C11orf54
5074


Q9H0W9_C154
C11orf54 Ester hydrolase C11orf54
5075


Q9UK59_C339
DBR1 Lariat debranching enzyme
5076


Q6P2Q9_C435
PRPF8 Pre-mRNA-processing-splicing
5077



factor 8


O75586_C137
MED6 Mediator of RNA polymerase II
5078



transcription subunit


Q99933_C213
BAG1 BAG family molecular
5079



chaperone regulator 1


Q9H4L5_C515
OSBPL3 Oxysterol-binding protein-
5080



related protein 3


Q14149_C694
MORC3 MORC family CW-type zinc
5081



finger protein 3


Q92546_C314
RGP1 Retrograde Golgi transport
5082



protein RGP1 homolog


P46821_C1228
MAP1B Microtubule-associated protein
5083



1B


O60343_C753
TBC1D4 TBC1 domain family member
5084



4


Q9UBT2_C432
UBA2 SUMO-activating enzyme
5085



subunit 2


Q86SQ0_C935
PHLDB2 Pleckstrin homology-like
5086



domain family B member 2


Q96A65_C957
EXOC4 Exocyst complex component 4
5087


O14980_C498
XPO1 Exportin-1
5088


Q9ULP9_C29
TBC1D24 TBC1 domain family
5089



member 24


P28290_C448
SSFA2 Sperm-specific antigen 2
5090


P31948_C62
STIP1 Stress-induced-phosphoprotein 1
5091


O95071_C739
UBR5 E3 ubiquitin-protein ligase
5092



UBR5


Q96L91_C694
EP400 E1A-binding protein p400
5093


Q9Y2L1_C357
DIS3 Exosome complex exonuclease
5094



RRP44


Q96L94_C184
SNX22 Sorting nexin-22
5095


Q15437_C40
SEC23B Protein transport protein
5096



Sec23B


Q9H0F6_C140
SHARPIN Sharpin
5097


Q6NZY4_C633
ZCCHC8 Zinc finger CCHC domain-
5098



containing protein 8


Q6NVY1_C271
HIBCH 3-hydroxyisobutyryl-CoA
5099



hydrolase, mitochondrial


P38432_C425
COIL Coilin
5100


Q29RF7_C508
PDS5A Sister chromatid cohesion
5101



protein PDS5 homolog A


Q29RF7_C925
PDS5A Sister chromatid cohesion
5102



protein PDS5 homolog A


Q8N5C7_C40
DTWD1 DTW domain-containing
5103



protein 1


O60437_C660
PPL Periplakin
5104


Q15042_C678
RAB3GAP1 Rab3 GTPase-activating
5105



protein catalytic subunit


O15111_C406
CHUK Inhibitor of nuclear factor
5106



kappa-B kinase subunit


P49915_C554
GMPS GMP synthase
5107


Q9Y490_C709
TLN1 Talin-1
5108


Q9Y490_C1661
TLN1 Talin-1
5109


Q9UGI8_C238
TES Testin
5110


Q9Y3D3_C26
MRPS16 28S ribosomal protein S16,
5111



mitochondrial


Q8WUY1_C104
THEM6 UPF0670 protein THEM6
5112


Q969Y2_C489
GTPBP3 tRNA modification GTPase
5113



GTPBP3, mitochondrial


Q13042_C194
CDC16 Cell division cycle protein 16
5114



homolog


Q8IWP9_C108
CCDC28A Coiled-coil domain-
5115



containing protein 28A


Q13469_C386
NFATC2 Nuclear factor of activated T-
5116



cells, cytoplasmic 2


Q13263_C232
TRIM28 Transcription intermediary
5117



factor 1-beta


Q16822_C210
PCK2 Phosphoenolpyruvate
5118



carboxykinase


Q96BY7_C891
ATG2B Autophagy-related protein 2
5119



homolog B


Q9H8M7_C27
FAM188A Protein FAM188A
5120


Q8N7H5_C36
PAF1 RNA polymerase II-associated
5121



factor 1 homolog


O00116_C226
AGPS
5122



Alkyldihydroxyacetonephosphate



synthase, peroxisom


O14641_C354
DVL2 Segment polarity protein
5123



dishevelled homolog DVL-2


P49588_C723
AARS Alanine--tRNA ligase,
5124



cytoplasmic


Q9H0G5_C171
NSRP1 Nuclear speckle splicing
5125



regulatory protein 1


Q9NZN5_C784
ARIIGEF12 Rho guanine nucleotide
5126



exchange factor 12


Q5JVF3_C362
PCID2 PCI domain-containing protein
5127



2


P56192_C566
MARS Methionine--tRNA ligase,
5128



cytoplasmic


P07954_C434
FH Fumarate hydratase, mitochondrial
5129


P09429_C106
HMGB1 High mobility group protein
5130



B1


Q9BVP2_C158
GNL3 Guanine nucleotide-binding
5131



protein-like 3


Q13813_C315
SPTAN1 Spectrin alpha chain, non-
5132



erythrocytic 1


Q66PJ3_C159
ARL6IP4 ADP-ribosylation factor-like
5133



protein 6-interacting


P55957_C15
BID BH3-interacting domain death
5134



agonist


Q9H4A3_C547
WNK1 Serine/threonine-protein kinase
5135



WNK1


P27797_C137
CALR Calreticulin
5136


P15498_C83
VAV1 Proto-oncogene vav
5137


Q9Y572_C365
RIPK3 Receptor-interacting
5138



serine/threonine-protein kina


Q8IX90_C290
SKA3 Spindle and kinetochore-
5139



associated protein 3


O96019_C32
ACTL6A Actin-like protein 6A
5140


P46939_C447
UTRN Utrophin
5141


P46939_C1759
UTRN Utrophin
5142


P52701_C1275
MSH6 DNA mismatch repair protein
5143



Msh6


Q14160_C1612
SCRIB Protein scribble homolog
5144


O14879_C39
IFIT3 Interferon-induced protein with
5145



tetratricopeptide


Q16543_C64
CDC37 Hsp90 co-chaperone Cdc37
5146


O75962_C868
TRIO Triple functional domain protein
5147


Q9H3S7_C1466
PTPN23 Tyrosine-protein phosphatase
5148



non-receptor type 23


P26196_C102
DDX6 Probable ATP-dependent RNA
5149



helicase DDX6


P33992_C207
MCM5 DNA replication licensing
5150



factor MCM5


O14893_C34
GEMIN2 Gem-associated protein 2
5151


Q86SE5_C51
RALYL RNA-binding Raly-like protein
5152


Q9BUN5_C13
CCDC28B Coiled-coil domain-
5153



containing protein 28B


Q9NR12_C388
PDLIM7 PDZ and LIM domain protein
5154



7


Q9NR19_C75
ACSS2 Acetyl-coenzyme A synthetase,
5155



cytoplasmic


Q9Y2X0_C790
MED16 Mediator of RNA polymerase
5156



II transcription subunit


Q9Y2X0_C801
MED16 Mediator of RNA polymerase
5157



II transcription subunit


Q00325_C237
SLC25A3 Phosphate carrier protein,
5158



mitochondrial


O95861_C243
BPNT1 3(2),5-bisphosphate
5159



nucleotidase 1


Q5VUA4_C475
ZNF318 Zinc finger protein 318
5160


Q8TDZ2_C837
MICAL1 Protein-methionine sulfoxide
5161



oxidase MICAL1


Q7RTV0_C61
PHF5A PHD finger-like domain-
5162



containing protein 5A


Q9Y4R8_C644
TELO2 Telomere length regulation
5163



protein TEL2 homolog


Q2PPJ7_C838
RALGAPA2 Ral GTPase-activating
5164



protein subunit alpha-2


P09382_C131
LGALS1 Galectin-1
5165


O95081_C30
AGFG2 Arf-GAP domain and FG
5166



repeat-containing protein 2


Q8WV74_C224
NUDT8 Nucleoside diphosphate-linked
5167



moiety X motif 8, mitochondrial


Q86Y37_C166
CACUL1 CDK2-associated and cullin
5168



domain-containing prote


O43414_C258
ERI3 ERI1 exoribonuclease 3
5169


Q6P0N0_C890
MIS18BP1 Mis18-binding protein 1
5170


Q5SW96_C286
LDLRAP1 Low density lipoprotein
5171



receptor adapter protein 1


Q96FW1_C212
OTUB1 Ubiquitin thioesterase OTUB1
5172


Q7Z7H8_C180
MRPL10 39S ribosomal protein L10,
5173



mitochondrial


P21266_C208
GSTM3 Glutathione S-transferase Mu 3
5174


Q8N5F7_C47
NKAP NF-kappa-B-activating protein
5175


Q00534_C83
CDK6 Cyclin-dependent kinase 6
5176


Q00537_C233
CDK17 Cyclin-dependent kinase 17
5177


Q13838_C300
DDX39B Spliceosome RNA helicase
5178



DDX39B


Q9HB09_C266
BCL2L12 Bcl-2-like protein 12
5179


P13693_C172
TPT1 Translationally-controlled tumor
5180



protein


Q9H6Q4_C300
NARFL Cytosolic Fe—S cluster
5181



assembly factor NARFL


P05388_C226
RPLP0 60S acidic ribosomal protein P0
5182


P16885_C937
PLCG2 1-phosphatidylinositol 4,5-
5183



bisphosphate phosphodiesterase


P16885_C1082
PLCG2 1-phosphatidylinositol 4,5-
5184



bisphosphate phosphodiesterase


Q13905_C474
RAPGEF1 Rap guanine nucleotide
5185



exchange factor 1


O75439_C485
PMPCB Mitochondrial-processing
5186



peptidase subunit beta


P43034_C168
PAFAH1B1 Platelet-activating factor
5187



acetylhydrolase IB subunit


A6NDG6_C35
PGP Phosphoglycolate phosphatase
5188


A6NDG6_C217
PGP Phosphoglycolate phosphatase
5189


O60610_C314
DIAPH1 Protein diaphanous homolog 1
5190


Q92598_C167
HSPH1 Heat shock protein 105 kDa
5191


Q13011_C92
ECH1 Delta(3,5)-Delta(2,4)-dienoyl-
5192



CoA isomerase, mitochondrial


Q8NEM2_C591
SHCBP1 SHC SH2 domain-binding
5193



protein 1


Q9NRH3_C13
TUBG2 Tubulin gamma-2 chain
5194


Q8NFC6_C1849
BOD1L1 Biorientation of chromosomes
5195



in cell division protein 1-like 1


Q7L8L6_C670
FASTKD5 FAST kinase domain-
5196



containing protein 5


Q13123_C263
IK Protein Red
5197


Q9UPN3_C666
MACF1 Microtubule-actin cross-
5198



linking factor 1, isoforms


Q9UPN3_C7245
MACF1 Microtubule-actin cross-
5199



linking factor 1, isoforms


Q9UPN7_C689
PPP6R1 Serine/threonine-protein
5200



phosphatase 6 regulatory


Q9UGP4_C374
LIMD1 LIM domain-containing protein
5201



1


Q9UGP4_C401
LIMD1 LIM domain-containing protein
5202



1


O75369_C183
FLNB Filamin-B
5203


O75369_C604
FLNB Filamin-B
5204


P40763_C687
STAT3 Signal transducer and activator
5205



of transcription 3


Q13347_C160
EIF3I Eukaryotic translation initiation
5206



factor 3 subunit


Q96KG9_C210
SCYL1 N-terminal kinase-like protein
5207


Q96KG9_C241
SCYL1 N-terminal kinase-like protein
5208


P21980_C27
TGM2 Protein-glutamine gamma-
5209



glutamyltransferase 2


P21980_C524
TGM2 Protein-glutamine gamma-
5210



glutamyltransferase 2


Q9ULJ6_C81
ZMIZ1 Zinc finger MIZ domain-
5211



containing protein 1


P30519_C265
HMOX2 Heme oxygenase 2
5212


Q96RE7_C178
NACC1 Nucleus accumbens-associated
5213



protein 1


Q96RE7_C301
NACC1 Nucleus accumbens-associated
5214



protein 1


Q96GX9_C32
APIP Probable methylthioribulose-1-
5215



phosphate dehydratase


P49792_C1335
RANBP2 E3 SUMO-protein ligase
5216



RanBP2


P49792_C2696
RANBP2 E3 SUMO-protein ligase
5217



RanBP2


P56545_C60
CTBP2 C-terminal-binding protein 2
5218


Q5SRE5_C1433
NUP188 Nucleoporin NUP188
5219



homolog


Q9P0L0_C128
VAPA Vesicle-associated membrane
5220



protein-associated protein A, 33 kDa


Q9Y618_C2447
NCOR2 Nuclear receptor corepressor 2
5221


Q9Y617_C175
PSAT1 Phosphoserine aminotransferase
5222


Q9Y617_C245
PSAT1 Phosphoserine aminotransferase
5223


Q9UIA9_C244
XPO7 Exportin-7
5224


Q9H8U3_C118
ZFAND3 AN1-type zinc finger protein
5225



3


O00506_C73
STK25 Serine/threonine-protein kinase
5226



25


Q4G0N4_C311
NADKD1 NAD kinase domain-
5227



containing protein 1


Q4V328_C744
GRIPAP1 GRIP1-associated protein 1
5228


Q9BXP5_C479
SRRT Serrate RNA effector molecule
5229



homolog


Q01581_C268
HMGCS1 Hydroxymethylglutaryl-CoA
5230



synthase, cytoplasmic


P46013_C643
MKI67 Antigen KI-67
5231


P17858_C351
PFKL 6-phosphofructokinase, liver
5232



type


Q9H7Z7_C110
PTGES2 Prostaglandin E synthase 2
5233


O75083_C194
WDR1 WD repeat-containing protein 1
5234


O43252_C127
PAPSS1 Bifunctional 3-
5235



phosphoadenosine 5-phosphosulfate



synthase 1


Q09028_C278
RBBP4 Histone-binding protein
5236



RBBP4


Q8WXH0_C1235
SYNE2 Nesprin-2
5237


Q9UPM8_C1119
AP4E1 AP-4 complex subunit epsilon-1
5238


P23368_C428
ME2 NAD-dependent malic enzyme,
5239



mitochondrial


O95402_C598
MED26 Mediator of RNA polymerase
5240



II transcription subunit


Q8TD19_C808
NEK9 Serine/threonine-protein kinase
5241



Nek9


P11216_C109
PYGB Glycogen phosphorylase, brain
5242



form


P40938_C11
RFC3 Replication factor C subunit 3
5243


P40939_C110
HADHA Trifunctional enzyme subunit
5244



alpha, mitochondrial


P40939_C550
HADHA Trifunctional enzyme subunit
5245



alpha, mitochondrial


Q8NCW5_C127
APOA1BP NAD(P)H-hydrate
5246



epimerase


Q13356_C15
PPIL2 Peptidyl-prolyl cis-trans
5247



isomerase-like 2


Q5F1R6_C3
DNAJC21 DnaJ homolog subfamily C
5248



member 21


P40337_C77
VHL Von Hippel-Lindau disease tumor
5249



suppressor


Q8N6R0_C226
METTL13 Methyltransferase-like
5250



protein 13


P39023_C336
RPL3 60S ribosomal protein L3
5251


P51610_C135
HCFC1 Host cell factor 1
5252


Q12800_C453
TFCP2 Alpha-globin transcription
5253



factor CP2


Q9Y281_C39
CFL2 Cofilin-2
5254


Q5T4S7_C1274
UBR4 E3 ubiquitin-protein ligase
5255



UBR4


Q5T4S7_C2222
UBR4 E3 ubiquitin-protein ligase
5256



UBR4


Q5T4S7_C4049
UBR4 E3 ubiquitin-protein ligase
5257



UBR4


O00154_C117
ACOT7 Cytosolic acyl coenzyme A
5258



thioester hydrolase


Q53EZ4_C159
CEP55 Centrosomal protein of 55 kDa
5259


Q5VV42_C138
CDKAL1 Threonylcarbamoyladenosine
5260



tRNA methylthiotransferase


Q9P2A4_C145
ABI3 ABI gene family member 3
5261


Q9BRR8_C839
GPATCH1 G patch domain-containing
5262



protein 1


Q9Y3I0_C122
C22orf28 tRNA-splicing ligase RtcB
5263



homolog


P28331_C92
NDUFS1 NADH-ubiquinone
5264



oxidoreductase 75 kDa subunit,



mitochondrial


P62826_C122
RAN GTP-binding nuclear protein Ran
5265


Q9BZE1_C153
MRPL37 39S ribosomal protein L37,
5266



mitochondrial


P01033_C197
TIMP1 Metalloproteinase inhibitor 1
5267


Q99661_C610
KIF2C Kinesin-like protein KIF2C
5268


Q99666_C1601
RGPD6 RANBP2-like and GRIP
5269



domain-containing protein 5/6


P24468_C343
NR2F2 COUP transcription factor 2
5270


O60701_C288
UGDH UDP-glucose 6-dehydrogenase
5271


O43488_C214
AKR7A2 Aflatoxin B1 aldehyde
5272



reductase member 2


P53618_C102
COPB1 Coatomer subunit beta
5273


Q8WV24_C148
PHLDA1 Pleckstrin homology-like
5274



domain family A member 1


Q8WV24_C266
PHLDA1 Pleckstrin homology-like
5275



domain family A member 1


Q8TEX9_C483
IPO4 Importin-4
5276


O95433_C301
AHSA1 Activator of 90 kDa heat shock
5277



protein ATPase homolog


P49327_C1992
FASN Fatty acid synthase
5278


Q99447_C30
PCYT2 Ethanolamine-phosphate
5279



cytidylyltransferase


P49321_C254
NASP Nuclear autoantigenic sperm
5280



protein


P14618_C165
PKM Pyruvate kinase isozymes M1/M2
5281


Q05655_C393
PRKCD Protein kinase C delta type
5282


Q14012_C179
CAMK1 Calcium/calmodulin-
5283



dependent protein kinase type 1


Q15746_C1077
MYLK Myosin light chain kinase,
5284



smooth muscle


O43353_C414
RIPK2 Receptor-interacting
5285



serine/threonine-protein kinase 2


P41091_C434
EIF2S3 Eukaryotic translation initiation
5286



factor 2 subunit


Q9BQ39_C603
DDX50 ATP-dependent RNA helicase
5287



DDX50


P13489_C38
RNH1 Ribonuclease inhibitor
5288


Q8TBC4_C70
UBA3 NEDD8-activating enzyme E1
5289



catalytic subunit


P25325_C65
MPST 3-mercaptopyruvate
5290



sulfurtransferase


O15287_C392
FANCG Fanconi anemia group G
5291



protein


P13804_C109
ETFA Electron transfer flavoprotein
5292



subunit alpha, mitochondrial


P31153_C149
MAT2A S-adenosylmethionine
5293



synthase isoform type-2


Q86V48_C594
LUZP1 Leucine zipper protein 1
5294


Q9UKU7_C351
ACAD8 Isobutyryl-CoA
5295



dehydrogenase, mitochondrial


Q12888_C772
TP53BP1 Tumor suppressor p53-
5296



binding protein 1


Q12888_C1796
TP53BP1 Tumor suppressor p53-
5297



binding protein 1


P14923_C511
JUP Junction plakoglobin
5298


Q8NBJ5_C203
GLT25D1 Procollagen
5299



galactosyltransferase 1


Q7LDG7_C398
RASGRP2 RAS guanyl-releasing
5300



protein 2


Q56VL3_C27
OCIAD2 OCIA domain-containing
5301



protein 2


P01591_C123
IGJ Immunoglobulin J chain
5302


Q9H1B7_C298
IRF2BPL Interferon regulatory factor
5303



2-binding protein-lik


O00522_C134
KRIT1 Krev interaction trapped protein
5304



1


Q9BZZ5_C234
API5 Apoptosis inhibitor 5
5305


Q9H8G2_C226
CAAP1 Caspase activity and apoptosis
5306



inhibitor 1


O60711_C379
LPXN Leupaxin
5307


Q6KC79_C279
NIPBL Nipped-B-like protein
5308


Q92974_C335
ARHGEF2 Rho guanine nucleotide
5309



exchange factor 2


P43007_C109
SLC1A4 Neutral amino acid transporter
5310



A


Q92973_C164
TNPO1 Transportin-1
5311


Q92973_C862
TNPO1 Transportin-1
5312


P54578_C359
USP14 Ubiquitin carboxyl-terminal
5313



hydrolase 14


Q92576_C561
PHF3 PHD finger protein 3
5314


Q13200_C285
PSMD2 26S proteasome non-ATPase
5315



regulatory subunit 2


P49336_C349
CDK8 Cyclin-dependent kinase 8
5316


Q8IVH4_C184
MMAA Methylmalonic aciduria type A
5317



protein, mitochondrial


Q9GZR7_C832
DDX24 ATP-dependent RNA helicase
5318



DDX24


Q15149_C888
PLEC Plectin
5319


Q15149_C1405
PLEC Plectin
5320


Q15149_C3493
PLEC Plectin
5321


Q15149_C3667
PLEC Plectin
5322


P25787_C213
PSMA2 Proteasome subunit alpha type-
5323



2


Q9ULW0_C198
TPX2 Targeting protein for Xklp2
5324


Q9UN19_C54
DAPP1 Dual adapter for
5325



phosphotyrosine and 3-phosphotyrosine



and 3-phosphoinositide


P40261_C115
NNMT Nicotinamide N-
5326



methyltransferase


Q9BWJ5_C41
SF3B5 Splicing factor 3B subunit 5
5327


Q9BR76_C345
CORO1B Coronin-1B
5328


Q9HB40_C191
SCPEP1 Retinoid-inducible serine
5329



carboxypeptidase


Q9BPZ3_C60
PAIP2 Polyadenylate-binding protein-
5330



interacting protein


Q96F07_C1265
CYFIP2 Cytoplasmic FMR1-interacting
5331



protein 2


Q8TCG1_C583
KIAA1524 Protein CIP2A
5332


O00442_C100
RTCA RNA 3-terminal phosphate
5333



cyclase


P06132_C308
UROD Uroporphyrinogen
5334



decarboxylase


Q9NTJ3_C260
SMC4 Structural maintenance of
5335



chromosomes protein 4


Q86UU0_C68
BCL9L B-cell CLL/lymphoma 9-like
5336



protein


Q15031_C167
LARS2 Probable leucine--tRNA ligase,
5337



mitochondrial


O15164_C394
TRIM24 Transcription intermediary
5338



factor 1-alpha


Q5VT52_C222
RPRD2 Regulation of nuclear pre-
5339



mRNA domain-containing protein 2


P22314_C179
UBA1 Ubiquitin-like modifier-
5340



activating enzyme 1


Q53GQ0_C215
HSD17B12 Estradiol 17-beta-
5341



dehydrogenase 12


P78527_C223
PRKDC DNA-dependent protein kinase
5342



catalytic subunit


P78527_C1629
PRKDC DNA-dependent protein kinase
5343



catalytic subunit


P42566_C824
EPS15 Epidermal growth factor
5344



receptor substrate 15


Q5VUJ6_C256
LRCH2 Leucine-rich repeat and
5345



calponin homology domain-containing



2


Q9H4I2_C11
ZHX3 Zinc fingers and homeoboxes
5346



protein 3


Q9H4I2_C335
ZHX3 Zinc fingers and homeoboxes
5347



protein 3


P42695_C631
NCAPD3 Condensin-2 complex subunit
5348



D3


Q96HE7_C104
ERO1L ERO1-like protein alpha
5349


Q53HL2_C273
CDCA8 Borealin
5350


Q9Y2L5_C265
TRAPPC8 Trafficking protein particle
5351



complex subunit 8


Q04721_C2085
NOTCH2 Neurogenic locus notch
5352



homolog protein 2


Q04726_C26
TLE3 Transducin-like enhancer protein
5353



3


Q6P2E9_C838
EDC4 Enhancer of mRNA-decapping
5354



protein 4


Q99567_C454
NUP88 Nuclear pore complex protein
5355



Nup88


P49189_C45
ALDH9A1 4-
5356



trimethylaminobutyraldehyde



dehydrogenase


Q14789_C3070
GOLGB1 Golgin subfamily B member
5357



1


Q14789_C3144
GOLGB1 Golgin subfamily B member
5358



1


O43592_C38
XPOT Exportin-T
5359


O43592_C938
XPOT Exportin-T
5360


Q9NUQ8_C102
ABCF3 ATP-binding cassette sub-
5361



family F member 3


P20810_C328
CAST Calpastatin
5362


P33176_C174
KIF5B Kinesin-1 heavy chain
5363


Q9GZQ3_C117
COMMD5 COMM domain-containing
5364



protein 5


P49454_C2415
CENPF Centromere protein F
5365


Q76N89_C1574
HECW1 E3 ubiquitin-protein ligase
5366



HECW1


Q9NQZ5_C362
STARD7 StAR-related lipid transfer
5367



protein 7, mitochondrial


Q9BQ15_C99
NABP2 SOSS complex subunit B1
5368


Q12905_C37
ILF2 Interleukin enhancer-binding
5369



factor 2


P04406_C158
GAPDH Glyceraldehyde-3-phosphate
5370



dehydrogenase


P11177_C306
PDHB Pyruvate dehydrogenase E1
5371



component subunit beta,


E7EQZ4_C60
SMN1 Survival motor neuron protein
5372


Q6UN15_C216
FIP1L1 Pre-mRNA 3-end-processing
5373



factor FIP1


Q96GJ1_C289
TRMT2B tRNA (uracil(54)-C(5))-
5374



methyltransferase homolog


Q9UEW8_C450
STK39 STE20/SPS1-related proline-
5375



alanine-rich protein kinase


Q15785_C236
TOMM34 Mitochondrial import
5376



receptor subunit TOM34


Q5T160_C11
RARS2 Probable arginine--tRNA
5377



ligase, mitochondrial


P40692_C142
MLH1 DNA mismatch repair protein
5378



Mlh1


Q15283_C314
RASA2 Ras GTPase-activating protein
5379



2


Q96I25_C302
RBM17 Splicing factor 45
5380


Q96I25_C385
RBM17 Splicing factor 45
5381


Q15334_C505
LLGL1 Lethal(2) giant larvae protein
5382



homolog 1


Q712K3_C191
UBE2R2 Ubiquitin-conjugating
5383



enzyme E2 R2


O95373_C90
IPO7 Importin-7
5384


Q9BV44_C426
THUMPD3 THUMP domain-
5385



containing protein 3


O14578_C105
CIT Citron Rho-interacting kinase
5386


O14579_C34
COPE Coatomer subunit epsilon
5387


Q9NXW9_C204
ALKBH4 Probable alpha-ketoglutarate-
5388



dependent dioxygenase


Q9Y2H0_C736
DLGAP4 Disks large-associated protein
5389



4


Q96CV9_C239
OPTN Optineurin
5390


Q9Y3L3_C102
SH3BP1 SH3 domain-binding protein 1
5391


Q96EV2_C1093
RBM33 RNA-binding protein 33
5392


Q9UM54_C1102
MYO6 Unconventional myosin-VI
5393


Q15027_C64
ACAP1 Arf-GAP with coiled-coil,
5394



ANK repeat and PH domain


O00541_C391
PES1 Pescadillo homolog
5395


Q9Y277_C36
VDAC3 Voltage-dependent anion-
5396



selective channel protein


Q9Y277_C229
VDAC3 Voltage-dependent anion-
5397



selective channel protein


Q8NI27_C743
THOC2 THO complex subunit 2
5398


O76094_C349
SRP72 Signal recognition particle 72
5399



kDa protein


Q14315_C1348
FLNC Filamin-C
5400


Q14315_C1735
FLNC Filamin-C
5401


Q09666_C1967
AHNAK Neuroblast differentiation-
5402



associated protein AHNA


P14621_C22
ACYP2 Acylphosphatase-2
5403


Q12974_C101
PTP4A2 Protein tyrosine phosphatase
5404



type IVA 2


O75334_C143
PPFIA2 Liprin-alpha-2
5405


O14979_C277
HNRPDL Heterogeneous nuclear
5406



ribonucleoprotein D-like


Q8WUM0_C1037
NUP133 Nuclear pore complex protein
5407



Nup133


Q96PN7_C876
TRERF1 Transcriptional-regulating
5408



factor 1


Q9H9A6_C54
LRRC40 Leucine-rich repeat-
5409



containing protein 40


Q01167_C357
FOXK2 Forkhead box protein K2
5410


Q13310_C128
PABPC4 Polyadenylate-binding protein
5411



4


P06493_C119
CDK1 Cyclin-dependent kinase 1
5412


P62937_C52
PPIA Peptidyl-prolyl cis-trans
5413



isomerase A


Q9UBQ5_C190
EIF3K Eukaryotic translation initiation
5414



factor 3 subunit


Q9NY93_C298
DDX56 Probable ATP-dependent RNA
5415



helicase DDX56


P50453_C370
SERPINB9 Serpin B9
5416


P12236_C160
SLC25A6 ADP/ATP translocase 3
5417


Q6ZRQ5_C1068
MMS22L Protein MMS22-like
5418


Q9BYI3_C371
FAM126A Hyccin
5419


P51148_C64
RAB5C Ras-related protein Rab-5C
5420


P09110_C87
ACAA1 3-ketoacyl-CoA thiolase,
5421



peroxisomal


Q9UL15_C118
BAG5 BAG family molecular
5422



chaperone regulator 5


Q9UL12_C497
SARDH Sarcosine dehydrogenase,
5423



mitochondrial


Q96CG3_C169
TIFA TRAF-interacting protein with
5424



FHA domain-containing


O60841_C853
EIF5B Eukaryotic translation initiation
5425



factor 5B


Q15306_C19
IRF4 Interferon regulatory factor 4
5426


Q9Y265_C94
RUVBL1 RuvB-like 1
5427


Q9Y263_C193
PLAA Phospholipase A-2-activating
5428



protein


Q9UBZ4_C27
APEX2 DNA-(apurinic or apyrimidinic
5429



site) lyase 2


O75528_C255
TADA3 Transcriptional adapter 3
5430


Q14997_C710
PSME4 Proteasome activator complex
5431



subunit 4


Q9P107_C895
GMIP GEM-interacting protein
5432


P35579_C740
MYH9 Myosin-9
5433


Q8TAQ2_C91
SMARCC2 SWI/SNF complex subunit
5434



SMARCC2


O14966_C120
RAB7L1 Ras-related protein Rab-7L1
5435


Q13325_C137
IFIT5 Interferon-induced protein with
5436



tetratricopeptide


Q7Z7A3_C290
CTU1 Cytoplasmic tRNA 2-thiolation
5437



protein 1


Q9ULT8_C2579
HECTD1 E3 ubiquitin-protein ligase
5438



HECTD1


Q0VG06_C15
FAAP100 Fanconi anemia-associated
5439



protein of 100 kDa


Q13439_C1253
GOLGA4 Golgin subfamily A member
5440



4


Q9UPT9_C494
USP22 Ubiquitin carboxyl-terminal
5441



hydrolase 22


Q9HCJ3_C362
RAVER2 Ribonucleoprotein PTB-
5442



binding 2


O60306_C28
AQR Intron-binding protein aquarius
5443


Q92879_C61
CELF1 CUGBP Elav-like family
5444



member 1


P10620_C50
MGST1 Microsomal glutathione S-
5445



transferase 1


P01892_C125
HLA-A HLA class I histocompatibility
5446



antigen, A-2 alpha


Q9Y312_C370
AAR2 Protein AAR2 homolog
5447


P55265_C392
ADAR Double-stranded RNA-specific
5448



adenosine deaminase


P60900_C78
PSMA6 Proteasome subunit alpha type-
5449



6


Q63ZY3_C249
KANK2 KN motif and ankyrin repeat
5450



domain-containing protein 2


Q63ZY3_C412
KANK2 KN motif and ankyrin repeat
5451



domain-containing protein


O95159_C230
ZFPL1 Zinc finger protein-like 1
5452


P62873_C294
GNB1 Guanine nucleotide-binding
5453



protein G(I)/G(S)/G(T)


O00567_C211
NOP56 Nucleolar protein 56
5454


Q15003_C397
NCAPH Condensin complex subunit 2
5455


Q9C0C2_C136
TNKS1BP1 182 kDa tankyrase-1-
5456



binding protein


Q9C0C9_C1099
UBE2O Ubiquitin-conjugating enzyme
5457



E2 O


Q12841_C233
FSTL1 Follistatin-related protein 1
5458


O75533_C1244
SF3B1 Splicing factor 3B subunit 1
5459


O75534_C106
CSDE1 Cold shock domain-containing
5460



protein E1


E7EVK2_C211
MTG1 Mitochondrial GTPase 1
5461


Q13158_C168
FADD Protein FADD
5462


Q9NRA8_C125
EIF4ENIF1 Eukaryotic translation
5463



initiation factor 4E transporter


Q13155_C205
AIMP2 Aminoacyl tRNA synthase
5464



complex-interacting multifunctional



protein 2


Q14192_C10
FHL2 Four and a half LIM domains
5465



protein 2


Q8TEU7_C93
RAPGEF6 Rap guanine nucleotide
5466



exchange factor 6


Q14204_C978
DYNC1H1 Cytoplasmic dynein 1
5467



heavy chain 1


Q14204_C4644
DYNC1H1 Cytoplasmic dynein 1
5468



heavy chain 1


O60684_C296
KPNA6 Importin subunit alpha-7
5469


Q92844_C318
TANK TRAF family member-
5470



associated NF-kappa-B activator


Q9Y4H4_C160
GPSM3 G-protein-signaling modulator
5471



3


Q8WXI9_C423
GATAD2B Transcriptional repressor
5472



p66-beta


P22102_C93
GART Trifunctional purine
5473



biosynthetic protein adenosine


P32320_C102
CDA Cytidine deaminase
5474


Q13085_C1116
ACACA Acetyl-CoA carboxylase 1
5475


Q14511_C18
NEDD9 Enhancer of filamentation 1
5476


O95551_C273
TDP2 Tyrosyl-DNA phosphodiesterase
5477



2


Q13330_C68
MTA1 Metastasis-associated protein
5478



MTA1


A6NJ78_C172
METTL15 Probable methyltransferase-
5479



like protein 15


O43491_C424
EPB41L2 Band 4.1-like protein 2
5480


P82663_C141
MRPS25 28S ribosomal protein S25,
5481



mitochondrial


Q13428_C1012
TCOF1 Treacle protein
5482


Q5JSP0_C43
FGD3 FYVE, RhoGEF and PH
5483



domain-containing protein 3


Q14847_C32
LASP1 LIM and SH3 domain protein 1
5484


Q9UHB7_C315
AFF4 AF4/FMR2 family member 4
5485


P48735_C402
IDH2 Isocitrate dehydrogenase
5486


Q2TAL8_C529
QRICH1 Glutamine-rich protein 1
5487


Q9UJM3_C124
ERRFI1 ERBB receptor feedback
5488



inhibitor 1


Q7L1V2_C87
MON1B Vacuolar fusion protein
5489



MON1 homolog B


Q96KP4_C205
CNDP2 Cytosolic non-specific
5490



dipeptidase


P62136_C62
PPP1CA Serine/threonine-protein
5491



phosphatase PP1-alpha catalytic subunit



alpha


P13984_C116
GTF2F2 General transcription factor
5492



IIF subunit 2


Q7L775_C337
EPM2AIP1 EPM2A-interacting protein
5493



1


P55209_C258
NAP1L1 Nucleosome assembly protein
5494



1-like 1


Q9NQR4_C146
NIT2 Omega-amidase NIT2
5495


Q13459_C1279
MYO9B Unconventional myosin-IXb
5496


Q9NVX0_C118
HAUS2 HAUS augmin-like complex
5497



subunit 2


Q969S9_C248
GFM2 Ribosome-releasing factor 2,
5498



mitochondrial


P14866_C260
HNRNPL Heterogeneous nuclear
5499



ribonucleoprotein L


Q13569_C233
TDG G/T mismatch-specific thymine
5500



DNA glycosylase


O95239_C28
KIF4A Chromosome-associated kinesin
5501



KIF4A


Q71RC2_C599
LARP4 La-related protein 4
5502


Q71RC2_C623
LARP4 La-related protein 4
5503


P29590_C80
PML Protein PML
5504


P29590_C151
PML Protein PML
5505


P29590_C189
PML Protein PML
5506


P29590_C227
PML Protein PML
5507


P29590_C479
PML Protein PML
5508


Q09472_C1621
EP300 Histone acetyltransferase p300
5509


O15235_C93
MRPS12 28S ribosomal protein S12,
5510



mitochondrial


P24534_C161
EEF1B2 Elongation factor 1-beta
5511


P54819_C92
AK2 Adenylate kinase 2, mitochondrial
5512


Q9Y333_C26
LSM2 U6 snRNA-associated Sm-like
5513



protein LSm2


Q9UER7_C427
DAXX Death domain-associated
5514



protein 6


Q3KQU3_C373
MAP7D1 MAP7 domain-containing
5515



protein 1


Q8N0W3_C129
FUK L-fucose kinase
5516


Q16401_C361
PSMD5 26S proteasome non-ATPase
5517



regulatory subunit 5


Q99590_C478
SCAF11 Protein SCAF11
5518


Q9BYX2_C686
TBC1D2 TBC1 domain family member
5519



2A


A2A288_C64
ZC3H12D Probable ribonuclease
5520



ZC3H12D


Q9UBR2_C214
CTSZ Cathepsin Z
5521


Q5U5Q3_C319
MEX3C RNA-binding E3 ubiquitin-
5522



protein ligase MEX3C


O95059_C31
RPP14 Ribonuclease P protein subunit
5523



p14


Q9NV56_C170
MRGBP MRG-binding protein
5524


O14617_C574
AP3D1 AP-3 complex subunit delta-1
5525


Q14980_C1937
NUMA1 Nuclear mitotic apparatus
5526



protein 1


Q9BYV9_C698
BACH2 Transcription regulator protein
5527



BACH2


P55072_C184
VCP Transitional endoplasmic
5528



reticulum ATPase


P55072_C209
VCP Transitional endoplasmic
5529



reticulum ATPase


Q01433_C848
AMPD2 AMP deaminase 2
5530


P55211_C172
CASP9 Caspase-9
5531


Q08378_C455
GOLGA3 Golgin subfamily A member
5532



3


Q12912_C264
LRMP Lymphoid-restricted membrane
5533



protein


Q07021_C186
C1QBP Complement component 1 Q
5534



subcomponent-binding protein


Q9NSE4_C414
IARS2 Isoleucine--tRNA ligase,
5535



mitochondrial


Q9NSE4_C883
IARS2 Isoleucine--tRNA ligase,
5536



mitochondrial


P14854_C30
COX6B1 Cytochrome c oxidase
5537



subunit 6B1


Q96ER3_C430
SAAL1 Protein SAAL1
5538


P08238_C592
HSP90AB1 Heat shock protein HSP
5539



90-beta


Q8IZ69_C551
TRMT2A tRNA (uracil-5-)-
5540



methyltransferase homolog A


Q8NFX7_C120
STXBP6 Syntaxin-binding protein 6
5541


Q15118_C223
PDK1
5542


Q9P2J5_C1052
LARS Leucine--tRNA ligase,
5543



cytoplasmic


Q9P2J5_C1053
LARS Leucine--tRNA ligase,
5544



cytoplasmic


Q8TF72_C1331
SHROOM3 Protein Shroom3
5545


Q01415_C407
GALK2 N-acetylgalactosamine kinase
5546


Q8IYL3_C124
C1orf174 UPF0688 protein C1orf174
5547


O43143_C644
DHX15 Putative pre-mRNA-splicing
5548



factor ATP-dependent RN


Q99615_C247
DNAJC7 DnaJ homolog subfamily C
5549



member 7


Q05086_C843
UBE3A Ubiquitin-protein ligase E3A
5550


P53667_C349
LIMK1 LIM domain kinase 1
5551


Q8IWV8_C1619
UBR2 E3 ubiquitin-protein ligase
5552



UBR2


Q96T51_C81
RUFY1 RUN and FYVE domain-
5553



containing protein 1


P13797_C209
PLS3 Plastin-3
5554


P39880_C802
CUX1 Homeobox protein cut-like 1
5555


Q53EL6_C288
PDCD4 Programmed cell death protein
5556



4


P12277_C283
CKB Creatine kinase B-type
5557


Q13617_C385
CUL2 Cullin-2
5558


Q8WXE1_C238
ATRIP ATR-interacting protein
5559


Q8WXE1_C263
ATRIP ATR-interacting protein
5560


Q7Z4Q2_C20
HEATR3 HEAT repeat-containing
5561



protein 3


Q15052_C564
ARHGEF6 Rho guanine nucleotide
5562



exchange factor 6


P49902_C181
NT5C2 Cytosolic purine 5-nucleotidase
5563


P49903_C119
SEPHS1 Selenide, water dikinase 1
5564


Q53EP0_C442
FNDC3B Fibronectin type III domain-
5565



containing protein 3B


Q92905_C218
COPS5 COP9 signalosome complex
5566



subunit 5


Q15121_C27
PEA15 Astrocytic phosphoprotein
5567



PEA-15


Q9Y315_C118
DERA Putative deoxyribose-phosphate
5568



aldolase


O75909_C23
CCNK Cyclin-K
5569


Q14232_C218
EIF2B1 Translation initiation factor
5570



eIF-2B subunit alpha


P53582_C22
METAP1 Methionine aminopeptidase 1
5571


Q8WZ42_C5248
TTN Titin
5572


Q6UB35_C828
MTHFD1L Monofunctional C1-
5573



tetrahydrofolate synthase,



mitochondrial


O43516_C446
WIPF1 WAS/WASL-interacting
5574



protein family member 1


Q9UHB4_C486
NDOR1 NADPH-dependent diflavin
5575



oxidoreductase 1


P41252_C400
IARS Isoleucine-tRNA ligase,
5576



cytoplasmic


Q9UHB6_C164
LIMA1 LIM domain and actin-binding
5577



protein 1


Q14141_C14
SEPT6 Septin-6
5578


Q14149_C307
MORC3 MORC family CW-type zinc
5579



finger protein 3


O75122_C528
CLASP2 CLIP-associating protein 2
5580


P46821_C905
MAP1B Microtubule-associated protein
5581



1B


P46821_C963
MAP1B Microtubule-associated protein
5582



1B


O60343_C295
TBC1D4 TBC1 domain family member
5583



4


Q96C36_C232
PYCR2 Pyrroline-5-carboxylate
5584



reductase 2


P61011_C229
SRP54 Signal recognition particle 54
5585



kDa protein


Q9H223_C141
EHD4 EH domain-containing protein 4
5586


O14981_C1542
BTAF1 TATA-binding protein-
5587



associated factor 172


P13796_C283
LCP1 Plastin-2
5588


O95071_C691
UBR5 E3 ubiquitin-protein ligase
5589



UBR5


O95071_C2768
UBR5 E3 ubiquitin-protein ligase
5590



UBR5


Q9Y2L1_C476
DIS3 Exosome complex exonuclease
5591



RRP44


A0FGR8_C181
ESYT2 Extended synaptotagmin-2
5592


P09960_C275
LTA4H Leukotriene A-4 hydrolase
5593


Q06330_C454
RBPJ Recombining binding protein
5594



suppressor of hairless


O14519_C105
CDK2AP1 Cyclin-dependent kinase 2-
5595



associated protein 1


Q15545_C72
TAF7 Transcription initiation factor
5596



TFIID subunit 7


Q15545_C92
TAF7 Transcription initiation factor
5597



TFIID subunit 7


Q15543_C38
TAF13 Transcription initiation factor
5598



TFIID subunit 13


Q6P587_C22
FAHD1 Acylpyruvase FAHD1,
5599



mitochondrial


P51649_C93
ALDH5A1 Succinate-semialdehyde
5600



dehydrogenase, mitochondrial


Q15048_C15
LRRC14 Leucine-rich repeat-
5601



containing protein 14


Q15042_C117
RAB3GAP1 Rab3 GTPase-activating
5602



protein catalytic subunit


Q15042_C873
RAB3GAP1 Rab3 GTPase-activating
5603



protein catalytic subunit


Q6R327_C1631
RICTOR Rapamycin-insensitive
5604



companion of mTOR


P49915_C530
GMPS GMP synthase
5605


Q9Y2K7_C840
KDM2A Lysine-specific demethylase
5606



2A


P00973_C25
OAS1 2-5-oligoadenylate synthase 1
5607


Q01780_C651
EXOSC10 Exosome component 10
5608


P12268_C468
IMPDH2 Inosine-5-monophosphate
5609



dehydrogenase 2


P07437_C129
TUBB Tubulin beta chain
5610


Q01658_C94
DR1 Protein Dr1
5611


Q9Y490_C29
TLN1 Talin-1
5612


Q9Y490_C1478
TLN1 Talin-1
5613


P43243_C821
MATR3 Matrin-3
5614


Q86W50_C253
METTL16 Methyltransferase-like
5615



protein 16


P49005_C447
POLD2 DNA polymerase delta subunit
5616



2


Q9H3H3_C199
C11orf68 UPF0696 protein C11orf68
5617


P27708_C484
CAD CAD protein
5618


Q709C8_C1481
VPS13C Vacuolar protein sorting-
5619



associated protein 13C


P23497_C373
SP100 Nuclear autoantigen Sp-100
5620


Q9NXV2_C25
KCTD5 BTB/POZ domain-containing
5621



protein KCTD5


Q05209_C470
PTPN12 Tyrosine-protein phosphatase
5622



non-receptor type 12


Q9P258_C305
RCC2 Protein RCC2
5623


Q8N3R9_C490
MPP5 MAGUK p55 subfamily member
5624



5


Q13464_C29
ROCK1 Rho-associated protein kinase
5625



1


Q7L5Y9_C195
MAEA Macrophage erythroblast
5626



attacher


O15446_C150
CD3EAP DNA-directed RNA
5627



polymerase I subunit RPA34


P54136_C36
RARS Arginine--tRNA ligase,
5628



cytoplasmic


P54136_C638
RARS Arginine--tRNA ligase,
5629



cytoplasmic


Q96F24_C155
NRBF2 Nuclear receptor-binding factor
5630



2


Q9Y5L0_C527
TNPO3 Transportin-3
5631


Q86YV5_C444
SGK223 Tyrosine-protein kinase
5632



SgK223


O60502_C663
MGEA5 Bifunctional protein NCOAT
5633


O60502_C896
MGEA5 Bifunctional protein NCOAT
5634


Q13671_C223
RIN1 Ras and Rab interactor 1
5635


O95067_C131
CCNB2 G2/mitotic-specific cyclin-B2
5636


P38646_C608
HSPA9 Stress-70 protein,
5637



mitochondrial


Q96MX6_C70
WDR92 WD repeat-containing protein
5638



92


P49588_C901
AARS Alanine--tRNA ligase,
5639



cytoplasmic


Q9HCC0_C391
MCCC2 Methylcrotonoyl-CoA
5640



carboxylase beta chain, mitochondrial


P47755_C157
CAPZA2 F-actin-capping protein
5641



subunit alpha-2


Q8TDD1_C73
DDX54 ATP-dependent RNA helicase
5642



DDX54


P47897_C111
QARS Glutamine--tRNA ligase
5643


P06730_C89
EIF4E Eukaryotic translation initiation
5644



factor 4E


P06730_C136
EIF4E Eukaryotic translation initiation
5645



factor 4E


Q7Z4W1_C150
DCXR L-xylulose reductase
5646


Q96QB1_C532
DLC1 Rho GTPase-activating protein 7
5647


P30740_C344
SERPINB1 Leukocyte elastase inhibitor
5648


O95758_C68
PTBP3 Polypyrimidine tract-binding
5649



protein 3


P00966_C132
ASS1 Argininosuccinate synthase
5650


P62917_C115
RPL8 60S ribosomal protein L8
5651


Q00796_C106
SORD Sorbitol dehydrogenase
5652


O75928_C346
PIAS2 E3 SUMO-protein ligase PIAS2
5653


Q8TF42_C367
UBASH3B Ubiquitin-associated and
5654



SH3 domain-containing protein


Q9NVR7_C298
TBCCD1 TBCC domain-containing
5655



protein 1


Q9UK39_C302
CCRN4L Nocturnin
5656


Q99627_C20
COPS8 COP9 signalosome complex
5657



subunit 8


Q9C0J8_C120
WDR33 pre-mRNA 3 end processing
5658



protein WDR33


Q6ZUJ8_C358
PIK3AP1 Phosphoinositide 3-kinase
5659



adapter protein 1


P23246_C431
SFPQ Splicing factor, proline- and
5660



glutamine-rich


P48506_C501
GCLC Glutamate--cysteine ligase
5661



catalytic subunit


Q04637_C821
EIF4G1 Eukaryotic translation
5662



initiation factor 4 gamma 1


P52701_C108
MSH6 DNA mismatch repair protein
5663



Msh6


P11310_C156
ACADM Medium-chain specific acyl-
5664



CoA dehydrogenase, mitochondrial


Q96G03_C86
PGM2 Phosphoglucomutase-2
5665


Q9NZ32_C352
ACTR10 Actin-related protein 10
5666


P32119_C70
PRDX2 Peroxiredoxin-2
5667


Q5R3I4_C128
TTC38 Tetratricopeptide repeat protein
5668



38


O43318_C513
MAP3K7 Mitogen-activated protein
5669



kinase kinase kinase 7


Q53H82_C21
LACTB2 Beta-lactamase-like protein 2
5670


P63165_C52
SUMO1 Small ubiquitin-related
5671



modifier 1


P33993_C566
MCM7 DNA replication licensing
5672



factor MCM7


P41567_C94
EIF1 Eukaryotic translation initiation
5673



factor 1


P22830_C395
FECH Ferrochelatase, mitochondrial
5674


P36871_C160
PGM1 Phosphoglucomutase-1
5675


Q9H0D6_C29
XRN2 5-3 exoribonuclease 2
5676


P31751_C124
AKT2 RAC-beta serine/threonine-
5677



protein kinase


P30622_C150
CLIP1 CAP-Gly domain-containing
5678



linker protein 1


Q06481_C133
APLP2 Amyloid-like protein 2
5679


Q9NR12_C311
PDLIM7 PDZ and LIM domain protein
5680



7


A6NHR9_C505
SMCHD1 Structural maintenance of
5681



chromosomes flexible hinge domain



containing 1


A6NHR9_C1656
SMCHD1 Structural maintenance of
5682



chromosomes flexible hinge domain



containing 1


O75600_C134
GCAT 2-amino-3-ketobutyrate
5683



coenzyme A ligase, mitochondrial


Q96IU2_C26
ZBED3 Zinc finger BED domain-
5684



containing protein 3


Q6PKG0_C1054
LARP1 La-related protein 1
5685


Q5VYS8_C343
ZCCHC6 Terminal uridylyltransferase
5686



7


P35580_C382
MYH10 Myosin-10
5687


P49023_C546
PXN Paxillin
5688


Q9NVS9_C72
PNPO Pyridoxine-5-phosphate oxidase
5689


Q9NQG7_C547
HPS4 Hermansky-Pudlak syndrome 4
5690



protein


Q14289_C562
PTK2B Protein-tyrosine kinase 2-beta
5691


Q96P47_C611
AGAP3 Arf-GAP with GTPase, ANK
5692



repeat and PH domain-containing



protein 3


Q92621_C921
NUP205 Nuclear pore complex protein
5693



Nup205


Q9BTA9_C615
WAC WW domain-containing adapter
5694



protein with coiled-coil


Q02241_C165
KIF23 Kinesin-like protein KIF23
5695


Q02241_C412
KIF23 Kinesin-like protein KIF23
5696


P41229_C1047
KDM5C Lysine-specific demethylase
5697



5C


Q92538_C158
GBF1 Golgi-specific brefeldin A-
5698



resistance guanine nucleotide exchange



factor 1


Q9UEY8_C73
ADD3 Gamma-adducin
5699


Q70J99_C448
UNC13D Protein unc-13 homolog D
5700


P20339_C63
RAB5A Ras-related protein Rab-5A
5701


Q9NZ08_C498
ERAP1 Endoplasmic reticulum
5702



aminopeptidase 1


Q9NZ09_C45
UBAP1 Ubiquitin-associated protein 1
5703


Q96IQ9_C75
ZNF414 Zinc finger protein 414
5704


Q96IQ9_C134
ZNF414 Zinc finger protein 414
5705


P55039_C270
DRG2 Developmentally-regulated
5706



GTP-binding protein 2


Q9H4A4_C254
RNPEP Aminopeptidase B
5707


P15170_C453
GSPT1 Eukaryotic peptide chain
5708



release factor GTP-binding subunit



ERF3A


O75152_C588
ZC3H11A Zinc finger CCCH domain-
5709



containing protein 11A


Q9BWD1_C158
ACAT2 Acetyl-CoA acetyltransferase,
5710



cytosolic


Q9UJX4_C203
ANAPC5 Anaphase-promoting
5711



complex subunit 5


Q96E11_C154
MRRF Ribosome-recycling factor,
5712



mitochondrial


Q16666_C679
IFI16 Gamma-interferon-inducible
5713



protein 16


O00622_C100
CYR61 Protein CYR61
5714


O00629_C417
KPNA4 Importin subunit alpha-4
5715


P40227_C282
CCT6A T-complex protein 1 subunit
5716



zeta


Q12830_C2697
BPTF Nucleosome-remodeling factor
5717



subunit BPTF


P48960_C513
CD97 CD97 antigen
5718


Q9NRZ9_C836
HELLS Lymphoid-specific helicase
5719


P02765_C230
AHSG Alpha-2-HS-glycoprotein
5720


Q9NTZ6_C545
RBM12 RNA-binding protein 12
5721


P20618_C89
PSMB1 Proteasome subunit beta type-1
5722


Q15365_C118
PCBP1 Poly(rC)-binding protein 1
5723


Q9BVL4_C629
SELO Selenoprotein O
5724


B5ME19_C79
EIF3CL Eukaryotic translation
5725



initiation factor 3 subunit


Q13905_C817
RAPGEF1 Rap guanine nucleotide
5726



exchange factor 1


P29401_C151
TKT Transketolase
5727


P29401_C206
TKT Transketolase
5728


P35244_C81
RPA3 Replication protein A 14 kDa
5729



subunit


Q8WUB8_C57
PHF10 PHD finger protein 10
5730


P49711_C155
CTCF Transcriptional repressor CTCF
5731


Q9UKL0_C35
RCOR1 REST corepressor 1
5732


Q92835_C506
INPP5D Phosphatidylinositol 3,4,5-
5733



trisphosphate 5-phosphase 1


Q9H3M7_C384
TXNIP Thioredoxin-interacting protein
5734


Q92598_C650
HSPH1 Heat shock protein 105 kDa
5735


Q09161_C36
NCBP1 Nuclear cap-binding protein
5736



subunit 1


Q99081_C129
TCF12 Transcription factor 12
5737


Q9Y4G6_C810
TLN2 Talin-2
5738


Q14566_C637
MCM6 DNA replication licensing
5739



factor MCM6


Q8NFQ8_C468
TOR1AIP2 Torsin-1A-interacting
5740



protein 2


Q15185_C20
PTGES3 Prostaglandin E synthase 3
5741


Q92619_C599
HMHA1 Minor histocompatibility
5742



protein HA-1


O94903_C15
PROSC Proline synthase co-transcribed
5743



bacterial homolog


Q8N999_C294
C12orf29 Uncharacterized protein
5744



C12orf29


Q8NFC6_C2384
BOD1L1 Biorientation of chromosomes
5745



in cell division protein


Q7L8L6_C689
FASTKD5 FAST kinase domain-
5746



containing protein 5


O43795_C779
MYO1B Unconventional myosin-Ib
5747


Q9UPN3_C4388
MACF1 Microtubule-actin cross-
5748



linking factor 1, isoforms


Q9UPN7_C455
PPP6R1 Serine/threonine-protein
5749



phosphatase 6 regulatory


O75569_C106
PRKRA Interferon-inducible double
5750



stranded RNA-dependent


Q9UPN9_C153
TRIM33 E3 ubiquitin-protein ligase
5751



TRIM33


Q9UPN9_C754
TRIM33 E3 ubiquitin-protein ligase
5752



TRIM33


Q9UPN9——C786
TRIM33 E3 ubiquitin-protein ligase
5753



TRIM33


Q96HA1_C307
POM121 Nuclear envelope pore
5754



membrane protein POM 121


Q99460_C633
PSMD1 26S proteasome non-ATPase
5755



regulatory subunit 1


Q8WY36_C150
BBX HMG box transcription factor
5756



BBX


Q8WY36_C712
BBX HMG box transcription factor
5757



BBX


P40763_C468
STAT3 Signal transducer and activator
5758



of transcription 3


Q70E73_C847
RAPH1 Ras-associated and pleckstrin
5759



homology domains-containing protein 1


Q9BZQ8_C891
FAM129A Protein Niban
5760


Q9NUU7_C224
DDX19A ATP-dependent RNA
5761



helicase DDX19A


Q96KG9_C503
SCYL1 N-terminal kinase-like protein
5762


Q96RU3_C248
FNBP1 Formin-binding protein 1
5763


Q14966_C1023
ZNF638 Zinc finger protein 638
5764


Q96FZ5_C12
CMTM7 CKLF-like MARVEL
5765



transmembrane domain-containing



protein 7


Q96FZ2_C97
C3orf37 UPF0361 protein C3orf37
5766


P49770_C194
EIF2B2 Translation initiation factor
5767



eIF-2B subunit beta


P40306_C215
PSMB10 Proteasome subunit beta type-
5768



10


O95639_C41
CPSF4 Cleavage and polyadenylation
5769



specificity factor subunit


P25208_C89
NFYB Nuclear transcription factor Y
5770



subunit beta


Q9BZ29_C628
DOCK9 Dedicator of cytokinesis
5771



protein 9


Q92688_C114
ANP32B Acidic leucine-rich nuclear
5772



phosphoprotein 32 family member B


Q9H6R7_C507
C2orf44 WD repeat-containing protein
5773



C2orf44


O15067_C1044
PFAS
5774



Phosphoribosylformylglycinamidine



synthase


P60891_C60
PRPS1 Ribose-phosphate
5775



pyrophosphokinase 1


Q86WN1_C449
FCHSD1 FCH and double SH3
5776



domains protein 1


Q8TAA5_C97
GRPEL2 GrpE protein homolog 2,
5777



mitochondrial


Q9NW64_C48
RBM22 Pre-mRNA-splicing factor
5778



RBM22


Q7Z4H7_C743
HAUS6 HAUS augmin-like complex
5779



subunit 6


Q13823_C336
GNL2 Nucleolar GTP-binding protein 2
5780


P49790_C148
NUP153 Nuclear pore complex protein
5781



Nup153


Q01813_C664
PFKP 6-phosphofructokinase type C
5782


P49792_C503
RANBP2 E3 SUMO-protein ligase
5783



RanBP2


P49792_C3040
RANBP2 E3 SUMO-protein ligase
5784



RanBP2


Q00341_C104
HDLBP Vigilin
5785


Q00610_C39
CLTC Clathrin heavy chain 1
5786


Q00610_C459
CLTC Clathrin heavy chain 1
5787


Q00610_C562
CLTC Clathrin heavy chain 1
5788


Q5SRE5_C585
NUP188 Nucleoporin NUP188
5789



homolog


Q9NVC6_C15
MED17 Mediator of RNA polymerase
5790



II transcription subunit


Q9NVC6_C110
MED17 Mediator of RNA polymerase
5791



II transcription subunit


Q96T76_C599
MMS19 MMS19 nucleotide excision
5792



repair protein homolog


Q9Y618_C1297
NCOR2 Nuclear receptor corepressor 2
5793


Q9Y618_C2179
NCOR2 Nuclear receptor corepressor 2
5794


Q969T4_C145
UBE2E3 Ubiquitin-conjugating enzyme
5795



E2 E3


Q9Y613_C936
FHOD1 FH1/FH2 domain-containing
5796



protein 1


P09543_C111
CNP 2,3-cyclic-nucleotide 3-
5797



phosphodiesterase


P32929_C252
CTH Cystathionine gamma-lyase
5798


O75427_C283
LRCH4 Leucine-rich repeat and
5799



calponin homology domain-containing



4


P07339_C110
CTSD Cathepsin D
5800


Q92734_C80
TFG Protein TFG
5801


Q00765_C118
REEP5 Receptor expression-enhancing
5802



protein 5


Q9Y4P8_C328
WIPI2 WD repeat domain
5803



phosphoinositide-interacting protein 2


Q4V328_C243
GRIPAP1 GRIP1-associated protein 1
5804


Q86UX6_C425
STK32C Serine/threonine-protein
5805



kinase 32C


P43155_C169
CRAT Carnitine O-acetyltransferase
5806


Q9BSJ8_C522
ESYT1 Extended synaptotagmin-1
5807


P35659_C161
DEK Protein DEK
5808


P27695_C208
APEX1 DNA-(apurinic or apyrimidinic
5809



site) lyase


P46013_C715
MKI67 Antigen KI-67
5810


P46013_C773
MKI67 Antigen KI-67
5811


Q9UJ70_C217
NAGK N-acetyl-D-glucosamine kinase
5812


Q7Z5J4_C322
RAI1 Retinoic acid-induced protein 1
5813


Q9NRG7_C78
SDR39U1 Epimerase family protein
5814



SDR39U1


Q8WXH0_C6161
SYNE2 Nesprin-2
5815


Q8TC07_C686
TBC1D15 TBC1 domain family
5816



member 15


Q8N4N3_C254
KLHL36 Kelch-like protein 36
5817


Q99459_C769
CDC5L Cell division cycle 5-like
5818



protein


P11216_C143
PYGB Glycogen phosphorylase, brain
5819



form


Q6WCQ1_C831
MPRIP Myosin phosphatase Rho-
5820



interacting protein


Q2TAZ0_C1458
ATG2A Autophagy-related protein 2
5821



homolog A


O43324_C147
EEF1E1 Eukaryotic translation
5822



elongation factor 1 epsilon


Q96MF7_C140
NSMCE2 E3 SUMO-protein ligase
5823



NSE2


Q14653_C222
IRF3 Interferon regulatory factor 3
5824


Q15428_C56
SF3A2 Splicing factor 3A subunit 2
5825


Q9UJU2_C321
LEF1 Lymphoid enhancer-binding
5826



factor 1


P60953_C18
CDC42 Cell division control protein 42
5827



homolog


P60953_C81
CDC42 Cell division control protein 42
5828



homolog


Q9NYZ3_C539
GTSE1 G2 and S phase-expressed
5829



protein 1


Q9UHY7_C202
ENOPH1 Enolase-phosphatase E1
5830


O94768_C190
STK17B Serine/threonine-protein
5831



kinase 17B


O15530_C21
PDPK1 3-phosphoinositide-dependent
5832



protein kinase 1


P21333_C810
FLNA Filamin-A
5833


P21333_C1723
FLNA Filamin-A
5834


P21333_C1865
FLNA Filamin-A
5835


P21333_C2107
FLNA Filamin-A
5836


Q9BWH6_C84
RPAP1 RNA polymerase II-associated
5837



protein 1


P51610_C292
HCFC1 Host cell factor 1
5838


P51610_C298
HCFC1 Host cell factor 1
5839


P51610_C1187
HCFC1 Host cell factor 1
5840


Q99683_C928
MAP3K5 Mitogen-activated protein
5841



kinase kinase kinase 5


Q9BWM7_C193
SFXN3 Sideroflexin-3
5842


Q96EM0_C205
L3HYPDH Trans-L-3-hydroxyproline
5843



dehydratase


Q96SZ5_C258
ADO 2-aminoethanethiol dioxygenase
5844


Q93100_C348
PHKB Phosphorylase b kinase
5845



regulatory subunit beta


O75410_C715
TACC1 Transforming acidic coiled-
5846



coil-containing protein


P35711_C492
SOX5 Transcription factor SOX-5
5847


Q9BXW9_C607
FANCD2 Fanconi anemia group D2
5848



protein


Q9Y4W2_C456
LAS1L Ribosomal biogenesis protein
5849



LAS1L


P27635_C80
RPL10 60S ribosomal protein L10
5850


O95294_C611
RASAL1 RasGAP-activating-like
5851



protein 1


Q9Y4E6_C1103
WDR7 WD repeat-containing protein 7
5852


Q92616_C939
GCN1L1 Translational activator GCN1
5853


Q92615_C633
LARP4B La-related protein 4B
5854


Q99661_C455
KIF2C Kinesin-like protein KIF2C
5855


Q9Y4E8_C264
USP15 Ubiquitin carboxyl-terminal
5856



hydrolase 15


P24468_C213
NR2F2 COUP transcription factor 2
5857


P43490_C39
NAMPT Nicotinamide
5858



phosphoribosyltransferase


Q8TE73_C4621
DNAH5 Dynein heavy chain 5,
5859



axonemal


Q99996_C3868
AKAP9 A-kinase anchor protein 9
5860


P46060_C141
RANGAP1 Ran GTPase-activating
5861



protein 1


Q8WV28_C343
BLNK B-cell linker protein
5862


Q8WV24_C242
PHLDA1 Pleckstrin homology-like
5863



domain family A member 1


P49327_C313
FASN Fatty acid synthase
5864


P49327_C1881
FASN Fatty acid synthase
5865


O75348_C104
ATP6V1G1 V-type proton ATPase
5866



subunit G 1


Q9UDR5_C342
AASS Alpha-aminoadipic
5867



semialdehyde synthase, mitochondrial


Q13363_C312
CTBP1 C-terminal-binding protein 1
5868


O14929_C376
HAT1 Histone acetyltransferase type B
5869



catalytic subunit


O14920_C464
IKBKB Inhibitor of nuclear factor
5870



kappa-B kinase subunit


Q9NYK6_C73
EURL Protein EURL homolog
5871


Q99536_C50
VAT1 Synaptic vesicle membrane
5872



protein VAT-1 homolog


Q8N1G2_C9
FTSJD2 Cap-specific mRNA
5873



(nucleoside-2-O-)-methyltransfe


Q96ME1_C459
FBXL18 F-box/LRR-repeat protein 18
5874


Q9BSQ5_C170
CCM2 Malcavernin
5875


Q00688_C133
FKBP3 Peptidyl-prolyl cis-trans
5876



isomerase FKBP3


Q96FX7_C217
TRMT61A tRNA (adenine(58)-N(1))-
5877



methyltransferase catalytic subunit


Q15691_C45
MAPRE1 Microtubule-associated
5878



protein RP/EB family member


Q9NS87_C576
KIF15 Kinesin-like protein KIF15
5879


P13489_C220
RNH1 Ribonuclease inhibitor
5880


Q9BPY3_C319
FAM118B Protein FAM118B
5881


Q63HN8_C4348
RNF213 E3 ubiquitin-protein ligase
5882



RNF213


Q14839_C1018
CHD4 Chromodomain-helicase-DNA-
5883



binding protein 4


Q14839_C1019
CHD4 Chromodomain-helicase-DNA-
5884



binding protein 4


Q14839_C1121
CHD4 Chromodomain-helicase-DNA-
5885



binding protein 4


Q9HD33_C87
MRPL47 39S ribosomal protein L47,
5886



mitochondrial


O14745_C206
SLC9A3R1 Na(+)/H(+) exchange
5887



regulatory cofactor NHE-RF1


O15287_C314
FANCG Fanconi anemia group G
5888



protein


Q7L2J0_C429
MEPCE 7SK snRNA methylphosphate
5889



capping enzyme


Q9BUK6_C561
MSTO1 Protein misato homolog 1
5890


Q9H5N1_C422
RABEP2 Rab GTPase-binding effector
5891



protein 2


Q7Z3K3_C1267
POGZ Pogo transposable element with
5892



ZNF domain


Q96EN8_C558
MOCOS Molybdenum cofactor
5893



sulfurase


P18074_C491
ERCC2 TFIIH basal transcription factor
5894



complex helicase


Q9UKU7_C251
ACAD8 Isobutyryl-CoA
5895



dehydrogenase, mitochondrial


Q96IY1_C175
NSL1 Kinetochore-associated protein
5896



NSL1 homolog


Q06136_C121
KDSR 3-ketodihydrosphingosine
5897



reductase


O75947_C101
ATP5H ATP synthase subunit d,
5898



mitochondrial


P14921_C99
ETS1 Protein C-ets-1
5899


Q9NRY4_C924
ARHGAP35 Rho GTPase-activating
5900



protein 35


O60832_C74
DKC1 H/ACA ribonucleoprotein
5901



complex subunit 4


O95352_C524
ATG7 Ubiquitin-like modifier-
5902



activating enzyme ATG7


O95359_C2573
TACC2 Transforming acidic coiled-
5903



coil-containing protein


Q6ZT12_C1858
UBR3 E3 ubiquitin-protein ligase
5904



UBR3


Q92990_C537
GLMN Glomulin
5905


Q9Y383_C193
LUC7L2 Putative RNA-binding protein
5906



Luc7-like 2


O75400_C39
PRPF40A Pre-mRNA-processing factor
5907



40 homolog A


P00519_C1100
ABL1 Tyrosine-protein kinase ABL1
5908


P17676_C11
CEBPB CCAAT/enhancer-binding
5909



protein beta


P53990_C125
IST1 IST1 homolog
5910


P08729_C274
KRT7 Keratin, type II cytoskeletal 7
5911


O15357_C1187
INPPL1 Phosphatidylinositol 3,4,5-
5912



trisphosphate 5-phosphatase 2


Q8IX01_C970
SUGP2 SURP and G-patch domain-
5913



containing protein 2


Q9Y4D8_C1488
HECTD4 Probable E3 ubiquitin-protein
5914



ligase HECTD4


O60711_C376
LPXN Leupaxin
5915


Q96IV0_C197
NGLY1 Peptide-N(4)-(N-acetyl-beta-
5916



glucosaminyl)asparagin


P35637_C428
FUS RNA-binding protein FUS
5917


Q6KC79_C1066
NIPBL Nipped-B-like protein
5918


Q92973_C467
TNPO1 Transportin-1
5919


Q92973_C683
TNPO1 Transportin-1
5920


Q9BTE1_C160
DCTN5 Dynactin subunit 5
5921


P54577_C501
YARS Tyrosine--tRNA ligase,
5922



cytoplasmic


O95218_C74
ZRANB2 Zinc finger Ran-binding
5923



domain-containing protein


Q9NPI1_C367
BRD7 Bromodomain-containing
5924



protein 7


Q92576_C1771
PHF3 PHD finger protein 3
5925


Q92575_C186
UBXN4 UBX domain-containing
5926



protein 4


P24928_C13
POLR2A DNA-directed RNA
5927



polymerase II subunit RPB1


P24928_C451
POLR2A DNA-directed RNA
5928



polymerase II subunit RPB1


P24928_C1287
POLR2A DNA-directed RNA
5929



polymerase II subunit RPB1


Q8IVH4_C100
MMAA Methylmalonic aciduria type A
5930



protein, mitochondrial


Q68E01_C596
INTS3 Integrator complex subunit 3
5931


Q15751_C2525
HERC1 Probable E3 ubiquitin-protein
5932



ligase HERC1


Q15751_C4811
HERC1 Probable E3 ubiquitin-protein
5933



ligase HERC1


Q8N680_C296
ZBTB2 Zinc finger and BTB domain-
5934



containing protein 2


Q13371_C35
PDCL Phosducin-like protein
5935


Q9ULW3_C37
ABT1 Activator of basal transcription 1
5936


O95602_C613
POLR1A DNA-directed RNA
5937



polymerase I subunit RPA1


O95602_C1332
POLR1A DNA-directed RNA
5938



polymerase I subunit RPA1


O94776_C44
MTA2 Metastasis-associated protein
5939



MTA2


P61081_C111
UBE2M NEDD8-conjugating enzyme
5940



Ubc12


P85037_C665
FOXK1 Forkhead box protein K1
5941


P62263_C31
RPS14 40S ribosomal protein S14
5942


Q08945_C200
SSRP1 FACT complex subunit SSRP1
5943


Q9ULE6_C750
PALD1 Paladin
5944


Q96F07_C223
CYFIP2 Cytoplasmic FMR1-interacting
5945



protein 2


Q15329_C121
E2F5 Transcription factor E2F5
5946


O95163_C213
IKBKAP Elongator complex protein 1
5947


Q6NXT1_C265
ANKRD54 Ankyrin repeat domain-
5948



containing protein 54


Q96EY5_C90
FAM125A Multivesicular body subunit
5949



12A


Q96CW6_C62
SLC7A6OS Probable RNA polymerase
5950



II nuclear localization protein


Q7L1Q6_C349
BZW1 Basic leucine zipper and W2
5951



domain-containing protein


P15880_C188
RPS2 40S ribosomal protein S2
5952


Q5VT52_C88
RPRD2 Regulation of nuclear pre-
5953



mRNA domain-containing protein 2


Q9BZI7_C319
UPF3B Regulator of nonsense
5954



transcripts 3B


Q9Y6K9_C131
IKBKG NF-kappa-B essential
5955



modulator


P78527_C1507
PRKDC DNA-dependent protein kinase
5956



catalytic subunit


P78527_C1791
PRKDC DNA-dependent protein kinase
5957



catalytic subunit


P78537_C61
BLOC1S1 Biogenesis of lysosome-
5958



related organelles complex


Q9Y6J0_C717
CABIN1 Calcineurin-binding protein
5959



cabin-1


Q15819_C69
UBE2V2 Ubiquitin-conjugating
5960



enzyme E2 variant 2


P52564_C38
MAP2K6 Dual specificity mitogen-
5961



activated protein kinase


Q8N556_C684
AFAP1 Actin filament-associated
5962



protein 1


Q6P4F2_C151
FDX1L Adrenodoxin-like protein,
5963



mitochondrial


O43598_C117
RCL Deoxyribonucleoside 5-
5964



monophosphate N-glycosidase


P07996_C813
THBS1 Thrombospondin-1
5965


P07996_C946
THBS1 Thrombospondin-1
5966


P07996_C1167
THBS1 Thrombospondin-1
5967


P41182_C175
BCL6 B-cell lymphoma 6 protein
5968


Q9BQC3_C251
DPH2 Diphthamide biosynthesis
5969



protein 2


O43572_C242
AKAP10 A-kinase anchor protein 10,
5970



mitochondrial


Q96RQ3_C129
MCCC1 Methylcrotonoyl-CoA
5971



carboxylase subunit alpha,



mitochondrial


Q96RQ3_C509
MCCC1 Methylcrotonoyl-CoA
5972



carboxylase subunit alpha,



mitochondrial


Q9ULV4_C23
CORO1C Coronin-1C
5973


Q7Z6M1_C29
RABEPK Rab9 effector protein with
5974



kelch motifs


Q9NX38_C74
FAM206A Protein FAM206A
5975


Q96HW7_C926
INTS4 Integrator complex subunit 4
5976


Q9HCD6_C431
TANC2 Protein TANC2
5977


Q13418_C239
ILK Integrin-linked protein kinase
5978


P55036_C87
PSMD4 26S proteasome non-ATPase
5979



regulatory subunit 4


P62072_C29
TIMM10 Mitochondrial import inner
5980



membrane translocase subunit


Q7Z2Z2_C474
EFTUD1 Elongation factor Tu GTP-
5981



binding domain-containing


O00231_C257
PSMD11 26S proteasome non-ATPase
5982



regulatory subunit 11


P05023_C374
ATP1A1 Sodium/potassium-
5983



transporting ATPase subunit alpha


P45985_C379
MAP2K4 Dual specificity mitogen-
5984



activated protein kinase


P17029_C63
ZKSCAN1 Zinc finger protein with
5985



KRAB and SCAN domains 1


Q9BSW2_C341
EFCAB4B EF-hand calcium-binding
5986



domain-containing protein


Q9P2R3_C34
ANKFY1 Ankyrin repeat and FYVE
5987



domain-containing protein


Q9P2R3_C716
ANKFY1 Ankyrin repeat and FYVE
5988



domain-containing protein


P31040_C536
SDHA Succinate dehydrogenase
5989


P09104_C357
ENO2 Gamma-enolase
5990


O76075_C108
DFFB DNA fragmentation factor
5991



subunit beta


Q9P2D3_C1546
HEATR5B HEAT repeat-containing
5992



protein 5B


Q9P2D6_C575
FAM135A Protein FAM135A
5993


Q15334_C697
LLGL1 Lethal(2) giant larvae protein
5994



homolog 1


P17735_C332
TAT Tyrosine aminotransferase
5995


Q9NXW9_C159
ALKBH4 Probable alpha-ketoglutarate-
5996



dependent dioxygenase


Q5BKX5_C271
C19orf54 UPF0692 protein C19orf54
5997


Q92888_C752
ARHGEF1 Rho guanine nucleotide
5998



exchange factor 1


Q96EV8_C302
DTNBP1 Dysbindin
5999


A6NC98_C1382
CCDC88B Coiled-coil domain-
6000



containing protein 88B


Q9UQR0_C324
SCML2 Sex comb on midleg-like
6001



protein 2


P04083_C263
ANXA1 Annexin A1
6002


Q3V6T2_C1729
CCDC88A Girdin
6003


Q12906_C278
ILF3 Interleukin enhancer-binding
6004



factor 3


Q14315_C2555
FLNC Filamin-C
6005


Q14315_C2660
FLNC Filamin-C
6006


O43813_C108
LANCL1 LanC-like protein 1
6007


Q8IY67_C297
RAVER1 Ribonucleoprotein PTB-
6008



binding 1


O43818_C416
RRP9 U3 small nucleolar RNA-
6009



interacting protein 2


Q9UI43_C126
FTSJ2 Putative ribosomal RNA
6010



methyltransferase 2


P04150_C287
NR3C1 Glucocorticoid receptor
6011


Q96JH7_C897
VCPIP1 Deubiquitinating protein
6012



VCIP135


Q9UJA5_C243
TRMT6 tRNA (adenine(58)-N(1))-
6013



methyltransferase non-catalytic subunit



TRM6


Q9UJA5_C492
TRMT6 tRNA (adenine(58)-N(1))-
6014



methyltransferase non-catalytic subunit



TRM6


Q6PJG6_C820
BRAT1 BRCA1-associated ATM
6015



activator 1


Q7LBC6_C509
KDM3B Lysine-specific demethylase
6016



3B


P62140_C104
PPP1CB Serine/threonine-protein
6017



phosphatase PP1-beta catalytic subunit



beta


P62140_C244
PPP1CB Serine/threonine-protein
6018



phosphatase PP1-beta catalytic subunit



beta


Q5JPH6_C314
EARS2 Probable glutamate--tRNA
6019



ligase, mitochondrial


P12429_C246
ANXA3 Annexin A3
6020


Q5D0E6_C468
DALRD3 DALR anticodon-binding
6021



domain-containing protein 3


Q13315_C2991
ATM Serine-protein kinase ATM
6022


P51116_C109
FXR2 Fragile X mental retardation
6023



syndrome-related protein


Q14683_C1210
SMC1A Structural maintenance of
6024



chromosomes protein 1A


P11766_C268
ADH5 Alcohol dehydrogenase class-3
6025


P11766_C282
ADH5 Alcohol dehydrogenase class-3
6026


Q8NI08_C302
NCOA7 Nuclear receptor coactivator 7
6027


Q9HD64_C33
XAGE1E G antigen family D member
6028



2


Q15796_C312
SMAD2 Mothers against
6029



decapentaplegic homolog 2


Q9UBC1_C304
NFKBIL1 NF-kappa-B inhibitor-like
6030



protein 1


Q9HB65_C15
ELL3 RNA polymerase II elongation
6031



factor ELL3


Q9HB65_C102
ELL3 RNA polymerase II elongation
6032



factor ELL3


Q9NUL3_C491
STAU2 Double-stranded RNA-binding
6033



protein Staufen homolo


Q9BYI3_C300
FAM126A Hyccin
6034


P51149_C143
RAB7A Ras-related protein Rab-7a
6035


P09110_C26
ACAA1 3-ketoacyl-CoA thiolase,
6036



peroxisomal


Q9UL15_C360
BAG5 BAG family molecular
6037



chaperone regulator 5


P55263_C160
ADK Adenosine kinase
6038


Q9UL12_C799
SARDH Sarcosine dehydrogenase,
6039



mitochondrial


O15061_C1225
SYNM Synemin
6040


Q9NP64_C52
ZCCHC17 Nucleolar protein of 40 kDa
6041


Q96S59_C527
RANBP9 Ran-binding protein 9
6042


O15382_C195
BCAT2 Branched-chain-amino-acid
6043



aminotransferase, mitochondrial


O15382_C345
BCAT2 Branched-chain-amino-acid
6044



aminotransferase, mitoch


P45974_C838
USP5 Ubiquitin carboxyl-terminal
6045



hydrolase 5


O14497_C1874
ARID1A AT-rich interactive domain-
6046



containing protein 1A


O75521_C368
ECI2 Enoyl-CoA delta isomerase 2,
6047



mitochondrial


Q92769_C111
HDAC2 Histone deacetylase 2
6048


Q96AE4_C148
FUBP1 Far upstream element-binding
6049



protein 1


Q8NFI3_C454
ENGASE Cytosolic endo-beta-N-
6050



acetylglucosaminidase


Q9P107_C336
GMIP GEM-interacting protein
6051


Q01469_C47
FABP5 Fatty acid-binding protein,
6052



epidermal


Q6PCE3_C303
PGM2L1 Glucose 1,6-bisphosphate
6053



synthase


Q9HAV0_C204
GNB4 Guanine nucleotide-binding
6054



protein subunit beta-4


Q9Y3C8_C69
UFC1 Ubiquitin-fold modifier-
6055



conjugating enzyme 1


Q8N806_C374
UBR7 Putative E3 ubiquitin-protein
6056



ligase UBR7


O43172_C299
PRPF4 U4/U6 small nuclear
6057



ribonucleoprotein Prp4


O94851_C552
MICAL2 Protein-methionine sulfoxide
6058



oxidase MICAL2


O60716_C692
CTNND1 Catenin delta-1
6059


O94855_C1022
SEC24D Protein transport protein
6060



Sec24D


Q9BQS8_C1062
FYCO1 FYVE and coiled-coil domain-
6061



containing protein 1


Q9BSC4_C16
NOL10 Nucleolar protein 10
6062


Q9H5X1_C90
FAM96A MIP18 family protein
6063



FAM96A


Q13325_C429
IFIT5 Interferon-induced protein with
6064



tetratricopeptide


Q13325_C476
IFIT5 Interferon-induced protein with
6065



tetratricopeptide


P23526_C228
AHCY Adenosylhomocysteinase
6066


Q9UG63_C586
ABCF2 ATP-binding cassette sub-
6067



family F member 2


Q9BQA1_C26
WDR77 Methylosome protein 50
6068


Q9BQA1_C172
WDR77 Methylosome protein 50
6069


Q9BQA1_C208
WDR77 Methylosome protein 50
6070


Q9UKJ3_C569
GPATCH8 G patch domain-containing
6071



protein 8


Q15654_C47
TRIP6 Thyroid receptor-interacting
6072



protein 6


P36873_C202
PPP1CC Serine/threonine-protein
6073



phosphatase PP1-gamma cat


Q8WXF1_C216
PSPC1 Paraspeckle component 1
6074


Q13555_C273
CAMK2G Calcium/calmodulin-
6075



dependent protein kinase type I


P55265_C622
ADAR Double-stranded RNA-specific
6076



adenosine deaminase


P60900_C115
PSMA6 Proteasome subunit alpha type-
6077



6


P50336_C183
PPOX Protoporphyrinogen oxidase
6078


Q63ZY3_C88
KANK2 KN motif and ankyrin repeat
6079



domain-containing prot


Q9HB71_C173
CACYBP Calcyclin-binding protein
6080


Q9P2T1_C224
GMPR2 GMP reductase 2
6081


Q5VIR6_C365
VPS53 Vacuolar protein sorting-
6082



associated protein 53 homolog


P51003_C677
PAPOLA Poly(A) polymerase alpha
6083


Q9NVE5_C50
USP40 Ubiquitin carboxyl-terminal
6084



hydrolase 40



R.NQGGTC*YLNSLLQTLHFTPEFR.E


Q9Y2Z2_C315
MTO1 Protein MTO1 homolog,
6085



mitochondrial


P30042_C52
C21orf33 ES1 protein homolog,
6086



mitochondrial


Q96CX6_C170
LRRC58 Leucine-rich repeat-
6087



containing protein 58


Q96CX2_C50
KCTD12 BTB/POZ domain-containing
6088



protein KCTD12


P18887_C20
XRCC1 DNA repair protein XRCC1
6089


Q9C0C9_C1288
UBE2O Ubiquitin-conjugating enzyme
6090



E2 O


O00762_C114
UBE2C Ubiquitin-conjugating enzyme
6091



E2 C


Q9Y520_C481
PRRC2C Protein PRRC2C
6092


Q9Y520_C953
PRRC2C Protein PRRC2C
6093


O75828_C227
CBR3 Carbonyl reductase
6094


O75534_C42
CSDE1 Cold shock domain-containing
6095



protein E1


P09651_C175
HNRNPA1 Heterogeneous nuclear
6096



ribonucleoprotein A1


Q9H7T3_C143
C10orf95 Uncharacterized protein
6097



C10orf95


Q96R06_C382
SPAG5 Sperm-associated antigen 5
6098


O43837_C185
IDH3B Isocitrate dehydrogenase
6099


Q96AD5_C312
PNPLA2 Patatin-like phospholipase
6100



domain-containing prote


Q96BD8_C142
SKA1 Spindle and kinetochore-
6101



associated protein 1


Q8NFH4_C311
NUP37 Nucleoporin Nup37
6102


Q9NRA8_C767
EIF4ENIF1 Eukaryotic translation
6103



initiation factor 4E transp


Q9NTM9_C248
CUTC Copper homeostasis protein
6104



cutC homolog


Q8TEU7_C1491
RAPGEF6 Rap guanine nucleotide
6105



exchange factor 6


Q14207_C842
NPAT Protein NPAT
6106


Q14204_C1932
DYNC1H1 Cytoplasmic dynein 1
6107



heavy chain 1


Q14204_C4510
DYNC1H1 Cytoplasmic dynein 1
6108



heavy chain 1


O60684_C273
KPNA6 Importin subunit alpha-7
6109


Q92841_C447
DDX17 Probable ATP-dependent RNA
6110



helicase DDX17


P07814_C1497
EPRS Bifunctional glutamate/proline--
6111



tRNA ligase


P19174_C247
PLCG1 1-phosphatidylinositol 4,5-
6112



bisphosphate phosphodie


P19174_C646
PLCG1 1-phosphatidylinositol 4,5-
6113



bisphosphate phosphodie


P22102_C466
GART Trifunctional purine
6114



biosynthetic protein adenosin


O75643_C238
SNRNP200 U5 small nuclear
6115



ribonucleoprotein 200 kDa helicas


O75643_C576
SNRNP200 U5 small nuclear
6116



ribonucleoprotein 200 kDa helicas


Q04759_C17
PRKCQ Protein kinase C theta type
6117


O94992_C122
HEXIM1 Protein HEXIM1
6118


P61106_C26
RAB14 Ras-related protein Rab-14
6119


P50851_C982
LRBA Lipopolysaccharide-responsive
6120



and beige-like ancho


P50851_C1228
LRBA Lipopolysaccharide-responsive
6121



and beige-like ancho


Q6FI81_C237
CIAPIN1 Anamorsin
6122


Q6FI81_C274
CIAPIN1 Anamorsin
6123


Q6FI81_C285
CIAPIN1 Anamorsin
6124


Q96RL1_C283
UIMC1 BRCA1-A complex subunit
6125



RAP80


O60264_C165
SMARCA5 SWI/SNF-related matrix-
6126



associated actin-dependent


P11586_C152
MTHFD1 C-1-tetrahydrofolate
6127



synthase, cytoplasmic


Q86Y56_C138
HEATR2 HEAT repeat-containing
6128



protein 2


Q15648_C681
MED1 Mediator of RNA polymerase II
6129



transcription subunit


Q6P4I2_C106
WDR73 WD repeat-containing protein
6130



73


P62318_C20
SNRPD3 Small nuclear
6131



ribonucleoprotein Sm D3


Q53HC9_C198
TSSC1 Protein TSSC1
6132


Q9BRF8_C143
CPPED1 Calcineurin-like
6133



phosphoesterase domain-containing


O95630_C221
STAMBP STAM-binding protein
6134


P30101_C92
PDIA3 Protein disulfide-isomerase A3
6135


P48200_C201
IREB2 Iron-responsive element-binding
6136



protein 2


O14730_C22
RIOK3 Serine/threonine-protein kinase
6137



RIO3


P09884_C306
POLA1 DNA polymerase alpha
6138



catalytic subunit


P09884_C1224
POLA1 DNA polymerase alpha
6139



catalytic subunit


P12034_C202
FGF5 Fibroblast growth factor 5
6140


P10768_C243
ESD S-formylglutathione hydrolase
6141


Q7L2E3_C1183
DHX30 Putative ATP-dependent RNA
6142



helicase DHX30


Q9UJM3_C113
ERRFI1 ERBB receptor feedback
6143



inhibitor 1


Q9UJM3_C204
ERRFI1 ERBB receptor feedback
6144



inhibitor 1


Q8WTW3_C318
COG1 Conserved oligomeric Golgi
6145



complex subunit 1


Q96KP1_C638
EXOC2 Exocyst complex component 2
6146


P62136_C245
PPP1CA Serine/threonine-protein
6147



phosphatase PP1-alpha cat


Q9NQR4_C44
NIT2 Omega-amidase NIT2
6148


P52948_C1711
NUP98 Nuclear pore complex protein
6149



Nup98-Nup96


O15014_C178
ZNF609 Zinc finger protein 609
6150


P13674_C167
P4HA1 Prolyl 4-hydroxylase subunit
6151



alpha-1


O95232_C43
LUC7L3 Luc7-like protein 3
6152


Q96JM3_C119
CHAMP1 Chromosome alignment-
6153



maintaining phosphoprotein 1


Q12857_C404
NFIA Nuclear factor 1 A-type
6154


O75818_C49
RPP40 Ribonuclease P protein subunit
6155



p40


Q8WYJ6_C102
SEPT1 Septin-1
6156


O75815_C360
BCAR3 Breast cancer anti-estrogen
6157



resistance protein 3


Q08J23_C235
NSUN2 tRNA (cytosine(34)-C(5))-
6158



methyltransferase


Q08J23_C758
NSUN2 tRNA (cytosine(34)-C(5))-
6159



methyltransferase


Q9H2U1_C135
DHX36 Probable ATP-dependent RNA
6160



helicase DHX36


Q86VQ1_C51
GLCCI1 Glucocorticoid-induced
6161



transcript 1 protein


Q04695_C336
KRT17 Keratin, type I cytoskeletal 17
6162


Q9Y530_C33
C6orf130 O-acetyl-ADP-ribose
6163



deacetylase C6orf130


Q9Y530_C122
C6orf130 O-acetyl-ADP-ribose
6164



deacetylase C6orf130


O43929_C16
ORC4 Origin recognition complex
6165



subunit 4


Q66K14_C289
TBC1D9B TBC1 domain family
6166



member 9B


Q8N0W3_C484
FUK L-fucose kinase
6167


Q8N0W3_C582
FUK L-fucose kinase
6168


P61812_C309
TGFB2 Transforming growth factor
6169



beta-2


Q86X10_C923
RALGAPB Ral GTPase-activating
6170



protein subunit beta


O95833_C219
CLIC3 Chloride intracellular channel
6171



protein 3


J3KR12_C95
Uncharacterized protein
6172


P12931_C280
SRC Proto-oncogene tyrosine-protein
6173



kinase Src


Q13535_C2336
ATR Serine/threonine-protein kinase
6174



ATR


Q6PIW4_C200
FIGNL1 Fidgetin-like protein 1
6175


Q6PIW4_C672
FIGNL1 Fidgetin-like protein 1
6176


P31939_C575
ATIC Bifunctional purine biosynthesis
6177



protein PURH


Q15291_C212
RBBP5 Retinoblastoma-binding protein
6178



5


O14618_C227
CCS Copper chaperone for superoxide
6179



dismutase


Q9BPW8_C106
NIPSNAP1 Protein NipSnap homolog 1
6180


Q9BPW8_C138
NIPSNAP1 Protein NipSnap homolog 1
6181


Q8IUC6_C192
TICAM1 TIR domain-containing
6182



adapter molecule 1


Q9P0V3_C787
SH3BP4 SH3 domain-binding protein 4
6183


P52888_C18
THOP1 Thimet oligopeptidase
6184


Q9H6T3_C519
RPAP3 RNA polymerase II-associated
6185



protein 3


Q07157_C1727
TJP1 Tight junction protein ZO-1
6186


Q15061_C380
WDR43 WD repeat-containing protein
6187



43


Q15067_C449
ACOX1 Peroxisomal acyl-coenzyme A
6188



oxidase 1


Q6P1X5_C1093
TAF2 Transcription initiation factor
6189



TFIID subunit 2


P67936_C154
TPM4 Tropomyosin alpha-4 chain
6190


Q92918_C484
MAP4K1 Mitogen-activated protein
6191



kinase kinase kinase kin


O15226_C37
NKRF NF-kappa-B-repressing factor
6192


Q9P2J5_C527
LARS Leucine--tRNA ligase,
6193



cytoplasmic


Q96GY3_C28
LIN37 Protein lin-37 homolog
6194


Q96GY3_C176
LIN37 Protein lin-37 homolog
6195


Q8TF72_C1104
SHROOM3 Protein Shroom3
6196


Q8TF72_C1367
SHROOM3 Protein Shroom3
6197


P62906_C164
RPL10A 60S ribosomal protein L10a
6198


Q86VP6_C356
CAND1 Cullin-associated NEDD8-
6199



dissociated protein 1


Q92597_C49
NDRG1 Protein NDRG1
6200


P35237_C370
SERPINB6 Serpin B6
6201


P30876_C177
POLR2B DNA-directed RNA
6202



polymerase II subunit RPB2


P30876_C622
POLR2B DNA-directed RNA
6203



polymerase II subunit RPB2


P14324_C62
FDPS Farnesyl pyrophosphate synthase
6204


Q9Y3F4_C152
STRAP Serine-threonine kinase
6205



receptor-associated protei


P27144_C22
AK4 Adenylate kinase isoenzyme 4,
6206



mitochondrial


Q14135_C167
VGLL4 Transcription cofactor
6207



vestigial-like protein 4


Q14135_C205
VGLL4 Transcription cofactor
6208



vestigial-like protein 4


O43143_C750
DHX15 Putative pre-mRNA-splicing
6209



factor ATP-dependent RN


Q8IW35_C599
CEP97 Centrosomal protein of 97 kDa
6210


P67775_C165
PPP2CA Serine/threonine-protein
6211



phosphatase 2A catalytic


P67775_C196
PPP2CA Serine/threonine-protein
6212



phosphatase 2A catalytic


Q92667_C64
AKAP1 A-kinase anchor protein 1,
6213



mitochondrial


Q32MZ4_C726
LKRFIP1 Leucine-rich repeat
6214



flightless-interacting protein


Q32MZ4_C750
LRRFIP1 Leucine-rich repeat
6215



flightless-interacting protein


Q99615_C58
DNAJC7 DnaJ homolog subfamily C
6216



member 7


Q99615_C175
DNAJC7 DnaJ homolog subfamily C
6217



member 7


Q99615_C225
DNAJC7 DnaJ homolog subfamily C
6218



member 7


Q05086_C198
UBE3A Ubiquitin-protein ligase E3A
6219


Q52LW3_C1215
ARHGAP29 Rho GTPase-activating
6220



protein 29


Q52LW3_C1239
ARHGAP29 Rho GTPase-activating
6221



protein 29


Q9UNS1_C700
TIMELESS Protein timeless homolog
6222


O94885_C1120
SASH1 SAM and SH3 domain-
6223



containing protein 1


P10619_C281
CTSA Lysosomal protective protein
6224


Q9UHQ1_C192
NARF Nuclear prelamin A recognition
6225



fector


Q9P2N6_C459
KANSL3 KAT8 regulatory NSL
6226



complex subunit 3


Q9ULC5_C322
ACSL5 Long-chain-fatty-acid--CoA
6227



ligase 5


O75116_C428
ROCK2 Rho-associated protein kinase
6228



2


P62330_C90
ARF6 ADP-ribosylation factor 6
6229


Q96G74_C434
OTUD5 OTU domain-containing
6230



protein 5


Q13444_C667
ADAM15 Disintegrin and
6231



metalloproteinase domain-containin


Q5UIP0_C1904
RIF1 Telomere-associated protein RIF1
6232


Q9NZB2_C919
FAM120A Constitutive coactivator of
6233



PPAR-gamma-like protei


O94805_C32
ACTL6B Actin-like protein 6B
6234


Q9UDY8_C71
MALT1 Mucosa-associated lymphoid
6235



tissue lymphoma translo


P06400_C590
RB1 Retinoblastoma-associated protein
6236


P55199_C433
ELL RNA polymerase II elongation
6237



factor ELL


P55199_C494
ELL RNA polymerase II elongation
6238



factor ELL


Q96KR1_C525
ZFR Zinc finger RNA-binding protein
6239


Q9H0K6_C640
PUS7L Pseudouridylate synthase 7
6240



homolog-like protein


Q96K76_C856
USP47 Ubiquitin carboxyl-terminal
6241



hydrolase 47


O14727_C115
APAF1 Apoptotic protease-activating
6242



factor 1


Q96N21_C52
ENTHD2 AP-4 complex accessory
6243



subunit tepsin


Q9HC38_C171
GLOD4 Glyoxalase domain-containing
6244



protein 4


Q9HC38_C221
GLOD4 Glyoxalase domain-containing
6245



protein 4


Q9NSD9_C76
FARSB Phenylalanine--tRNA ligase
6246



beta subunit


O75376_C1274
NCOR1 Nuclear receptor corepressor 1
6247


O75376_C2322
NCOR1 Nuclear receptor corepressor 1
6248


Q15058_C291
KIF14 Kinesin-like protein KIF14
6249


Q15050_C52
RRS1 Ribosome biogenesis regulatory
6250



protein homolog


Q15052_C667
ARHGEF6 Rho guanine nucleotide
6251



exchange factor 6


O00592_C344
PODXL Podocalyxin
6252


P49903_C317
SEPHS1 Selenide, water dikinase 1
6253


E7EVH7_C562
KLC1 Kinesin light chain 1
6254


Q9Y6A5_C242
TACC3 Transforming acidic coiled-
6255



coil-containing protein


Q6P1K8_C299
GTF2H2D General transcription factor
6256



IIH subunit 2-like pr


Q3B7T1_C589
EDRF1 Erythroid differentiation-
6257



related factor 1


Q9H0W8_C411
SMG9 Protein SMG9
6258


Q86XP3_C281
DDX42 ATP-dependent RNA helicase
6259



DDX42


Q08257_C45
CRYZ Quinone oxidoreductase
6260


O75879_C170
PET112 Glutamyl-tRNA(Gln)
6261



amidotransferase subunit B,



mitochondrial


Q92696_C354
RABGGTA Geranylgeranyl transferase
6262



type-2 subunit alpha


Q15772_C1052
SPEG Striated muscle preferentially
6263



expressed protein k


O75616_C348
ERAL1 GTPase Era, mitochondrial
6264


Q6UB35_C291
MTHFD1L Monofunctional C1-
6265



tetrahydrofolate synthase,



mitochondrial


Q8N392_C323
ARHGAP18 Rho GTPase-activating
6266



protein 18


Q9UHR6_C188
ZNHIT2 Zinc finger HIT domain-
6267



containing protein 2


P57081_C95
WDR4 tRNA (guanine-N(7)-)-
6268



methyltransferase subunit WDR


Q9H4L4_C274
SENP3 Sentrin-specific protease 3
6269


Q14149_C632
MORC3 MORC family CW-type zinc
6270



finger protein 3


O95455_C175
TGDS dTDP-D-glucose 4,6-
6271



dehydratase


O95453_C169
PARN Poly(A)-specific ribonuclease
6272



PARN


Q99426_C216
TBCB Tubulin-folding cofactor B
6273


Q16566_C202
CAMK4 Calcium/calmodulin-
6274



dependent protein kinase type I


Q9Y5P6_C113
GMPPB Mannose-1-phosphate
6275



guanyltransferase beta


Q9UBT2_C158
UBA2 SUMO-activating enzyme
6276



subunit 2


Q96C36_C225
PYCR2 Pyrroline-5-carboxylate
6277



reductase 2


Q6NS38_C192
ALKBH2 Alpha-ketoglutarate-
6278



dependent dioxygenase alkB homolog 2


Q86SQ0_C385
PHLDB2 Pleckstrin homology-like
6279



domain family B member 2


Q6DKI1_C184
RPL7L1 60S ribosomal protein L7-like
6280



1


Q06203_C503
PPAT Amidophosphoribosyltransferase
6281


Q7Z6I6_C965
ARHGAP30 Rho GTPase-activating
6282



protein 30


Q9ULP9_C223
TBC1D24 TBC1 domain family
6283



member 24


P34897_C343
SHMT2 Serine
6284



hydroxymethyltransferase,



mitochondrial


P49736_C315
MCM2 DNA replication licensing
6285



factor MCM2


O95071_C2094
UBR5 E3 ubiquitin-protein ligase
6286



UBR5


O95071_C2173
UBR5 E3 ubiquitin-protein ligase
6287



UBR5


Q96L91_C162
EP400 E1A-binding protein p400
6288


Q6XZF7_C1434
DNMBP Dynamin-binding protein
6289


P34949_C11
MPI Mannose-6-phosphate isomerase
6290


Q15437_C180
SEC23B Protein transport protein
6291



Sec23B


P09960_C543
LTA4H Leukotriene A-4 hydrolase
6292


P30460_C349
HLA-B HLA class I histocompatibility
6293



antigen, B-8 alpha


Q9BVS4_C449
RIOK2 Serine/threonine-protein kinase
6294



RIO2


O15027_C1273
SEC16A Protein transport protein
6295



Sec16A


O15027_C1619
SEC16A Protein transport protein
6296



Sec16A


Q9NQW7_C279
XPNPEP1 Xaa-Pro aminopeptidase 1
6297


Q96EB6_C380
SIRT1 NAD-dependent protein
6298



deacetylase sirtuin-1


P10398_C514
ARAF Serine/threonine-protein kinase
6299



A-Raf


Q15046_C456
KARS Lysine--tRNA ligase
6300


Q15046_C534
KARS Lysine--tRNA ligase
6301


Q12802_C1548
AKAP13 A-kinase anchor protein 13
6302


Q12802_C2101
AKAP13 A-kinase anchor protein 13
6303


Q9H7B4_C421
SMYD3 SET and MYND domain-
6304



containing protein 3


Q13867_C40
BLMH Bleomycin hydrolase
6305


Q13867_C189
BLMH Bleomycin hydrolase
6306


Q13404_C71
UBE2V1 Ubiquitin-conjugating
6307



enzyme E2 variant 1


Q9BVA0_C344
KATNB1 Katanin p80 WD40-
6308



containing subunit B1


O60504_C521
SORBS3 Vinexin
6309


P07437_C127
TUBB Tubulin beta chain
6310


Q96SW2_C287
CRBN Protein cereblon
6311


Q9Y490_C1023
TLN1 Talin-1
6312


Q9Y490_C2161
TLN1 Talin-1
6313


Q86W56_C963
PARG Poly(ADP-ribose)
6314



glycohydrolase


P49005_C83
POLD2 DNA polymerase delta subunit
6315



2


P49005_C404
POLD2 DNA polymerase delta subunit
6316



2


P49006_C134
MARCKSL1 MARCKS-related protein
6317


Q05932_C209
FPGS Folylpolyglutamate synthase,
6318



mitochondrial


Q9Y3D6_C41
FIS1 Mitochondrial fission 1 protein
6319


O94916_C270
NFAT5 Nuclear factor of activated T-
6320



cells 5


P27708_C1374
CAD CAD protein
6321


Q96LB3_C53
IFT74 Intraflagellar transport protein 74
6322



homolog


Q96EY9_C13
ADAT3 tRNA-specific adenosine
6323



deaminase-like protein 3


O75608_C211
LYPLA1 Acyl-protein thioesterase 1
6324


P22033_C433
MUT Methylmalonyl-CoA mutase,
6325



mitochondrial


O43290_C560
SART1 U4/U6.U5 tri-snRNP-
6326



associated protein 1


O43617_C31
TRAPPC3 Trafficking protein particle
6327



complex subunit 3


Q9P258_C337
RCC2 Protein RCC2
6328


P61313_C110
RPL15 60S ribosomal protein L15
6329


O95684_C244
FGFR1OP FGFR1 oncogene partner
6330


Q17RN3_C36
FAM98C Protein FAM98C
6331


P11498_C372
PC Pyruvate carboxylase,
6332



mitochondrial


Q13263_C152
TRIM28 Transcription intermediary
6333



factor 1-beta


Q13263_C717
TRIM28 Transcription intermediary
6334



factor 1-beta


O75131_C385
CPNE3 Copine-3
6335


Q16762_C64
TST Thiosulfate sulfurtransferase
6336


Q02790_C103
FKBP4 Peptidyl-prolyl cis-trans
6337



isomerase FKBP4


Q02790_C342
FKBP4 Peptidyl-prolyl cis-trans
6338



isomerase FKBP4


P26358_C41
DNMT1 DNA (cytosine-5)-
6339



methyltransferase 1


P26358_C580
DNMT1 DNA (cytosine-5)-
6340



methyltransferase 1


Q8TEM1_C767
NUP210 Nuclear pore membrane
6341



glycoprotein 210


P61006_C23
RAB8A Ras-related protein Rab-8A
6342


O15446_C55
CD3EAP DNA-directed RNA
6343



polymerase I subunit RPA34


P54136_C115
RARS Arginine--tRNA ligase,
6344



cytoplasmic


P36551_C319
CPOX Coproporphyrinogen-III
6345



oxidase, mitochondrial


Q86YV5_C155
SGK223 Tyrosine-protein kinase
6346



SgK223


Q86YV5_C221
SGK223 Tyrosine-protein kinase
6347



SgK223


Q96PV6_C529
LENG8 Leukocyte receptor cluster
6348



member 8


P30520_C182
ADSS Adenylosuccinate synthetase
6349



isozyme 2


Q9NV88_C578
INTS9 Integrator complex subunit 9
6350


P49589_C182
CARS Cysteine--tRNA ligase,
6351



cytoplasmic


P15374_C50
UCHL3 Ubiquitin carboxyl-terminal
6352



hydrolase isozyme L3


P55735_C299
SEC13 Protein SEC13 homolog
6353


Q9NR09_C1547
BIRC6 Baculoviral IAP repeat-
6354



containing protein 6


A8MVX7_C100
Uncharacterized protein
6355


P56192_C333
MARS Methionine--tRNA ligase,
6356



cytoplasmic


Q8NAG6_C517
ANKLE1 Ankyrin repeat and LEM
6357



domain-containing protein 1


P55884_C302
EIF3B Eukaryotic translation initiation
6358



factor 3 subunit


Q86V15_C35
CASZ1 Zinc finger protein castor
6359



homolog 1


Q9H2G2_C1153
SLK STE20-like serine/threonine-
6360



protein kinase


Q99570_C899
PIK3R4 Phosphoinositide 3-kinase
6361



regulatory subunit 4


Q9BVP2_C251
GNL3 Guanine nucleotide-binding
6362



protein-like 3


Q13813_C1454
SPTAN1 Spectrin alpha chain, non-
6363



erythrocytic 1


Q6P3S1_C21
DENND1B DENN domain-containing
6364



protein 1B


P07737_C71
PFN1 Profilin-1
6365


O00425_C546
IGF2BP3 Insulin-like growth factor 2
6366



mRNA-binding protein


Q9H832_C154
UBE2Z Ubiquitin-conjugating enzyme
6367



E2 Z


Q9H832_C261
UBE2Z Ubiquitin-conjugating enzyme
6368



E2 Z


Q9UKV8_C188
EIF2C2 Protein argonaute-2
6369


Q00796_C350
SORD Sorbitol dehydrogenase
6370


Q9Y376_C121
CAB39 Calcium-binding protein 39
6371


P00492_C66
HPRT1 Hypoxanthine-guanine
6372



phosphoribosyltransferase


Q9NVR5_C727
DNAAF2 Protein kintoun
6373


P15498_C652
VAV1 Proto-oncogene vav
6374


Q92499_C668
DDX1 ATP-dependent RNA helicase
6375



DDX1


P08559_C261
PDHA1 Pyruvate dehydrogenase E1
6376



component subunit alpha,


Q8IUY3_C274
GRAMD2 GRAM domain-containing
6377



protein 2


Q96PE3_C854
INPP4A Type I inositol 3,4-
6378



bisphosphate 4-phosphatase


Q9NPD8_C86
UBE2T Ubiquitin-conjugating enzyme
6379



E2 T


Q9H307_C439
PNN Pinin
6380


P46939_C2003
UTRN Utrophin
6381


P46939_C2098
UTRN Utrophin
6382


P46939_C3076
UTRN Utrophin
6383


Q04637_C934
EIF4G1 Eukaryotic translation
6384



initiation factor 4 gamma 1


D6RAD4_C204
CDK7 Cyclin-dependent kinase 7
6385


P52701_C579
MSH6 DNA mismatch repair protein
6386



Msh6


O60292_C1322
SIPA1L3 Signal-induced proliferation-
6387



associated 1-like protein


Q16831_C17
UPP1 Uridine phosphorylase 1
6388


P49368_C372
CCT3 T-complex protein 1 subunit
6389



gamma


O75962_C1717
TRIO Triple functional domain protein
6390


O75962_C2327
TRIO Triple functional domain protein
6391


Q53H82_C100
LACTB2 Beta-lactamase-like protein 2
6392


Q5TC12_C321
ATPAF1 ATP synthase mitochondrial
6393



F1 complex assembly factor 1


P33992_C221
MCM5 DNA replication licensing
6394



factor MCM5


P12081_C455
HARS Histidine--tRNA ligase,
6395



cytoplasmic


Q15418_C432
RPS6KA1 Ribosomal protein S6 kinase
6396



alpha-1


P49590_C236
HARS2 Probable histidine--tRNA
6397



ligase, mitochondrial


O14893_C63
GEMIN2 Gem-associated protein 2
6398


Q9H0D6_C557
XRN2 5-3 exoribonuclease 2
6399


Q4G0F5_C334
VPS26B Vacuolar protein sorting-
6400



associated protein 26B


P08567_C59
PLEK Pleckstrin
6401


P50135_C196
HNMT Histamine N-methyltransferase
6402


Q9BXF6_C66
RAB11FIP5 Rab11 family-interacting
6403



protein 5


P51668_C111
UBE2D1 Ubiquitin-conjugating
6404



enzyme E2 D1


Q5T0L3_C212
C1orf111 Uncharacterized protein
6405



C1orf111


A6NHR9_C897
SMCHD1 Structural maintenance of
6406



chromosomes flexible hinge domain



containing 1


A6NHR9_C1899
SMCHD1 Structural maintenance of
6407



chromosomes flexible hinge domain



containing 1


Q12824_C167
SMARCB1 SWI/SNF-related matrix-
6408



associated actin-dependent


Q969R8_C438
ITFG2 Integrin-alpha FG-GAP repeat-
6409



containing protein 2


P17544_C61
ATF7 Cyclic AMP-dependent
6410



transcription factor ATF-7


O00410_C1057
IPO5 Importin-5
6411


Q9BT25_C354
HAUS8 HAUS augmin-like complex
6412



subunit 8


O95861_C206
BPNT1 3(2),5-bisphosphate
6413



nucleotidase 1


O15260_C32
SURF4 Surfeit locus protein 4
6414


P35580_C1238
MYH10 Myosin-10
6415


P35270_C171
SPR Sepiapterin reductase
6416


P42330_C193
AKR1C3 Aldo-keto reductase family 1
6417



member C3


P42331_C302
ARHGAP25 Rho GTPase-activating
6418



protein 25


Q9Y230_C227
RUVBL2 RuvB-like 2
6419


Q92621_C877
NUP205 Nuclear pore complex protein
6420



Nup205


Q92621_C1297
NUP205 Nuclear pore complex protein
6421



Nup205


P42025_C222
ACTR1B Beta-centractin
6422


Q5H9R7_C844
PPP6R3 Serine/threonine-protein
6423



phosphatase 6 regulatory


Q02241_C447
KIF23 Kinesin-like protein KIF23
6424


O94915_C888
FRYL Protein furry homolog-like
6425


P53621_C245
COPA Coatomer subunit alpha
6426


P53621_C522
COPA Coatomer subunit alpha
6427


O43678_C58
NDUFA2 NADH dehydrogenase
6428


Q14116_C74
IL18 Interleukin-18
6429


Q86Y37_C362
CACUL1 CDK2-associated and cullin
6430



domain-containing protein


Q99704_C115
DOK1 Docking protein 1
6431


O75153_C214
KIAA0664 Clustered mitochondria
6432



protein homolog


Q99961_C147
SH3GL1 Endophilin-A2
6433


O43294_C416
TGFB1I1 Transforming growth factor
6434



beta-1-induced transcript 1


Q7Z7H8_C213
MRPL10 39S ribosomal protein L10,
6435



mitochondrial


Q96IF1_C182
AJUBA LIM domain-containing
6436



protein ajuba


Q8NC26_C51
ZNF114 Zinc finger protein 114
6437


Q8NC26_C136
ZNF114 Zinc finger protein 114
6438


P21266_C39
GSTM3 Glutathione S-transferase Mu 3
6439


Q8WXA9_C494
SREK1 Splicing regulatory
6440



glutamine/lysine-rich protein









Table 4 illustrates an exemplary list of cysteine-containing proteins identified in a human T cell. Table 4 further shows the accession number (or the protein identifier) of the protein, cysteine residue number, and an illustrative peptide fragment containing the cysteine of interest (denoted by C*).











TABLE 4







SEQ




ID


Identifier
Protein Name
NO:

















Q13418_C239
ILK Integrin-linked protein kinase
6441


P07203_C156
GPX1 Glutathione peroxidase 1
6442


P00390_C102
GSR Glutathione reductase,
6443



mitochondrial


P07203_C78
GPX1 Glutathione peroxidase 1
6444


Q9BRA2_C43
TXNDC17 Thioredoxin domain-
6445



containing protein 17


Q01844_C524
EWSR1 RNA-binding protein EWS
6446


Q99798_C385
ACO2 Aconitate hydratase,
6447



mitochondrial


P18031_C215
PTPN1 Tyrosine-protein phosphatase
6448



non-receptor type 1


Q9Y2R4_C536
DDX52 Probable ATP-dependent RNA
6449



helicase DDX52


P53621_C921
COPA Coatomer subunit alpha
6450


P31930_C380
UQCRC1 Cytochrome b-c1 complex
6451



subunit 1, mitochondrial


P09211_C48
GSTP1 Glutathione S-transferase P
6452


P46459_C264
NSF Vesicle-fusing ATPase
6453


Q9NR56_C43
MBNL1 Muscleblind-like protein 1
6454


Q5VZF2_C43
MBNL2 Muscleblind-like protein 2
6455


P49368_C455
CCT3 T-complex protein 1 subunit
6456



gamma


P47756_C62
CAPZB F-actin-capping protein
6457



subunit beta


P57737_C42
CORO7 Coronin-7
6458


Q9BV79_C263
MECR Trans-2-enoyl-CoA reductase,
6459



mitochondrial


P13010_C339
XRCC5 X-ray repair cross-
6460



complementing protein 5


Q9H2U2_C302
PPA2 Inorganic pyrophosphatase 2,
6461



mitochondrial


P13010_C346
XRCC5 X-ray repair cross-
6462



complementing protein 5


Q16875_C102
PFKFB3 6-phosphofructo-2-
6463



kinase/fructose-2,6-bisphosphata


P14866_C452
HNRNPL Heterogeneous nuclear
6464



ribonucleoprotein L


Q99798_C448
ACO2 Aconitate hydratase,
6465



mitochondrial


Q99798_C451
ACO2 Aconitate hydratase,
6466



mitochondrial


Q9C0B1_C326
FTO Alpha-ketoglutarate-dependent
6467



dioxygenase FTO


Q92947_C115
GCDH Glutaryl-CoA dehydrogenase,
6468



mitochondrial


Q92597_C168
NDRG1 Protein NDRG1
6469


P09874_C298
PARP1 Polymerase 2
6470


P55036_C58
PSMD4 26S proteasome non-ATPase
6471



regulatory subunit 4


A6NHR9_C1433
SMCHD1 Structural maintenance of
6472



chromosomes flexible hinge domain-



containing protein 1


Q2M2I8_C270
AAK1 AP2-associated protein kinase 1
6473


O14880_C56
MGST3 Microsomal glutathione S-
6474



transferase 3


Q9C0J8_C120
WDR33 pre-mRNA 3 end processing
6475



protein WDR33


Q96ME7_C430
ZNF512 Zinc finger protein 512
6476


Q01813_C641
PFKP 6-phosphofructokinase type C
6477


P21333_C810
FLNA Filamin-A
6478


P07858_C108
CTSB Cathepsin B
6479


Q9UGI8_C22
TES Testin
6480


P48047_C141
ATP5O ATP synthase subunit O,
6481



mitochondrial


P27707_C59
DCK Deoxycytidine kinase
6482


Q9C0J8_C249
WDR33 pre-mRNA 3 end processing
6483



protein WDR33


Q9UMS4_C298
PRPF19 Pre-mRNA-processing factor
6484



19


P25705_C294
ATP5A1 ATP synthase subunit alpha,
6485



mitochondrial


H3BQZ7_C518
Uncharacterized protein
6486


Q1KMD3_C518
HNRNPUL2 Heterogeneous nuclear
6487



ribonucleoprotein U-like protein 2


Q8IW45_C82
CARKD ATP-dependent (S)-
6488



NAD(P)H-hydrate dehydratase


P09110_C177
ACAA1 3-ketoacyl-CoA thiolase,
6489



peroxisomal


P34949_C11
MPI Mannose-6-phosphate isomerase
6490


Q7RTV0_C49
PHF5A PHD finger-like domain-
6491



containing protein 5A


Q9BWD1_C65
ACAT2 Acetyl-CoA acetyltransferase,
6492



cytosolic


P48735_C154
IDH2 Isocitrate dehydrogenase
6493


P51665_C116
PSMD7 26S proteasome non-ATPase
6494



regulatory subunit 7


Q6YN16_C218
HSDL2 Hydroxysteroid
6495



dehydrogenase-like protein 2


P14866_C581
HNRNPL Heterogeneous nuclear
6496



ribonucleoprotein L


P78417_C32
GSTO1 Glutathione S-transferase
6497



omega-1


P51610_C1872
HCFC1 Host cell factor 1
6498


Q86WV6_C206
TMEM173 Transmembrane protein
6499



173


P08559_C181
PDHA1 Pyruvate dehydrogenase E1
6500



component subunit alpha, somatic



form, mitochondrial


O60318_C1285
MCM3AP 80 kDa MCM3-associated
6501



protein


P78527_C4106
PRKDC DNA-dependent protein
6502



kinase catalytic subunit


P31943_C34
HNRNPH1 Heterogeneous nuclear
6503



ribonucleoprotein H


P62333_C170
PSMC6 26S protease regulatory
6504



subunit 10B


O14776_C1062
TCERG1 Transcription elongation
6505



regulator 1


Q9Y3Z3_C341
SAMHD1 SAM domain and HD
6506



domain-containing protein 1


Q96GM5_C460
SMARCD1 SWI/SNF-related matrix-
6507



associated actin-dependent


P29350_C361
PTPN6 Tyrosine-protein phosphatase
6508



non-receptor type 6


P14625_C645
HSP90B1 Endoplasmin
6509


P10515_C586
DLAT Dihydrolipoyllysine-residue
6510



acetyltransferase component of



pyruvate dehydrogenase complex,



mitochondrial


P02042_C94
HBD Hemoglobin subunit delta
6511


P14174_C81
MIF Macrophage migration inhibitory
6512



factor


P04083_C343
ANXA1 Annexin A1
6513


P04406_C247
GAPDH Glyceraldehyde-3-phosphate
6514



dehydrogenase


O94901_C657
SUN1 SUN domain-containing protein
6515



1


Q9UH99_C563
SUN2 SUN domain-containing protein
6516



2


P13796_C42
LCP1 Plastin-2
6517


O95985_C217
TOP3B DNA topoisomerase 3-beta-1
6518


P00367_C376
GLUD1 Glutamate dehydrogenase 1,
6519



mitochondrial


P49840_C380
GSK3A Glycogen synthase kinase-3
6520



alpha


P12814_C154
ACTN1 Alpha-actinin-1
6521


P55084_C458
HADHB Trifunctional enzyme subunit
6522



beta, mitochondrial


P63220_C56
RPS21 40S ribosomal protein S21
6523


O43707_C173
ACTN4 Alpha-actinin-4
6524


Q49A26_C356
GLYR1 Putative oxidoreductase
6525



GLYR1


Q9NYL9_C231
TMOD3 Tropomodulin-3
6526


Q63HN8_C2943
RNF213 E3 ubiquitin-protein ligase
6527



RNF213


P27987_C740
ITPKB Inositol-trisphosphate 3-kinase
6528



B


Q96F15_C185
GIMAP5 GTPase IMAP family
6529



member 5


Q13501_C131
SQSTM1 Sequestosome-1
6530


P00441_C147
SOD1 Superoxide dismutase
6531


Q92616_C1362
GCN1L1 Translational activator GCN1
6532


Q08J23_C321
NSUN2 tRNA (cytosine(34)-C(5))-
6533



methyltransferase


Q01518_C416
CAP1 Adenylyl cyclase-associated
6534



protein 1


P55735_C245
SEC13 Protein SEC13 homolog
6535


P08133_C59
ANXA6 Annexin A6
6536


P62910_C96
RPL32 60S ribosomal protein L32
6537


P62306_C66
SNRPF Small nuclear
6538



ribonucleoprotein F


I3L420_C311
LSM14A Protein LSM14 homolog A
6539


Q8ND56_C375
LSM14A Protein LSM14 homolog A
6540


P57737_C187
CORO7 Coronin-7
6541


Q96FS4_C609
SIPA1 Signal-induced proliferation-
6542



associated protein 1


Q8TD19_C487
NEK9 Serine/threonine-protein kinase
6543



Nek9


Q99567_C561
NUP88 Nuclear pore complex protein
6544



Nup88


P21333_C631
FLNA Filamin-A
6545


P26583_C23
HMGB2 High mobility group protein
6546



B2


P09429_C23
HMGB1 High mobility group protein
6547



B1


Q99460_C898
PSMD1 26S proteasome non-ATPase
6548



regulatory subunit 1


Q92785_C53
DPF2 Zinc finger protein ubi-d4
6549


Q16822_C431
PCK2 Phosphoenolpyruvate
6550



carboxykinase


O95671_C441
ASMTL N-acetylserotonin O-
6551



methyltransferase-like protein


Q9UGI8_C412
TES Testin
6552


Q13574_C905
DGKZ Diacylglycerol kinase zeta
6553


Q9UGI8_C416
TES Testin
6554


Q9NZA1_C191
CLIC5 Chloride intracellular channel
6555



protein 5


P43354_C566
NR4A2 Nuclear receptor subfamily 4
6556



group A member 2


P22736_C566
NR4A1 Nuclear receptor subfamily 4
6557



group A member 1


Q96EP0_C504
RNF31 E3 ubiquitin-protein ligase
6558



RNF31


P30048_C229
PRDX3 Thioredoxin-dependent
6559



peroxide reductase, mitochondrial


P21333_C210
FLNA Filamin-A
6560


Q08AF3_C627
SLFN5 Schlafen family member 5
6561


Q92608_C465
DOCK2 Dedicator of cytokinesis
6562



protein 2


O75592_C1868
MYCBP2 Probable E3 ubiquitin-
6563



protein ligase MYCBP2


P21333_C205
FLNA Filamin-A
6564


P21333_C2160
FLNA Filamin-A
6565


P30626_C57
SRI Sorcin
6566


Q9P2T1_C348
GMPR2 GMP reductase 2
6567


Q52LJ0_C295
FAM98B Protein FAM98B
6568


Q13813_C956
SPTAN1 Spectrin alpha chain, non-
6569



erythrocytic 1


Q8NCA5_C293
FAM98A Protein FAM98A
6570


Q96G03_C573
PGM2 Phosphoglucomutase-2
6571


O75832_C107
PSMD10 26S proteasome non-ATPase
6572



regulatory subunit 10


O95372_C213
LYPLA2 Acyl-protein thioesterase 2
6573


Q5JVS0_C22
HABP4 Intracellular hyaluronan-
6574



binding protein 4


Q9BPZ7_C149
MAPKAP1 Target of rapamycin
6575



complex 2 subunit MAPKAP1


Q8NE71_C655
ABCF1 ATP-binding cassette sub-
6576



family F member 1


P48059_C100
LIMS1 LIM and senescent cell antigen-
6577



like-containing domain 1


Q13263_C83
TRIM28 Transcription intermediary
6578



factor 1-beta


Q13263_C88
TRIM28 Transcription intermediary
6579



factor 1-beta


Q13263_C91
TRIM28 Transcription intermediary
6580



factor 1-beta


Q9Y4H4_C116
GPSM3 G-protein-signaling modulator
6581



3


O00139_C537
KIF2A Kinesin-like protein KIF2A
6582


A6NHR9_C897
SMCHD1 Structural maintenance of
6583



chromosomes flexible hinge domain



containing 1


Q12824_C350
SMARCB1 SWI/SNF-related matrix-
6584



associated actin-dependent


Q96EP5_C85
DAZAP1 DAZ-associated protein 1
6585


Q96ME7_C413
ZNF512 Zinc finger protein 512
6586


Q13813_C1622
SPTAN1 Spectrin alpha chain, non-
6587



erythrocytic 1


Q8WWQ0_C28
PHIP PH-interacting protein
6588


P22736_C303
NR4A1 Nuclear receptor subfamily 4
6589



group A member 1


Q9P2N6_C459
KANSL3 KAT8 regulatory NSL
6590



complex subunit 3


Q93084_C447
ATP2A3 Sarcoplasmic/endoplasmic
6591



reticulum calcium ATPase


Q92945_C436
KHSRP Far upstream element-binding
6592



protein 2


O75643_C1278
SNRNP200 U5 small nuclear
6593



ribonucleoprotein 200 kDa helicase


P14866_C260
HNRNPL Heterogeneous nuclear
6594



ribonucleoprotein L


H7BZ11_C83
Uncharacterized protein
6595


H7BZ11_C88
Uncharacterized protein
6596


Q969Q0_C72
RPL36AL 60S ribosomal protein L36a-
6597



like


Q969Q0_C77
RPL36AL 60S ribosomal protein L36a-
6598



like


P14866_C261
HNRNPL Heterogeneous nuclear
6599



ribonucleoprotein L


P15927_C219
RPA2 Replication protein A 32 kDa
6600



subunit


Q92598_C290
HSPH1 Heat shock protein 105 kDa
6601


P22307_C71
SCP2 Non-specific lipid-transfer
6602



protein


P26358_C896
DNMT1 DNA (cytosine-5)-
6603



methyltransferase 1


Q06830_C173
PRDX1 Pcroxiredoxin-1
6604


P42765_C287
ACAA2 3-ketoacyl-CoA thiolase,
6605



mitochondrial


O75592_C2163
MYCBP2 Probable E3 ubiquitin-
6606



protein ligase MYCBP2


Q9Y4W2_C504
LAS1L Ribosomal biogenesis protein
6607



LAS1L


A6NHR9_C1856
SMCHD1 Structural maintenance of
6608



chromosomes flexible hinge domain



containing 1


O75351_C240
VPS4B Vacuolar protein sorting-
6609



associated protein 4B


P52333_C811
JAK3 Tyrosine-protein kinase JAK3
6610


P52564_C216
MAP2K6 Dual specificity mitogen-
6611



activated protein kinase


P31146_C40
CORO1A Coronin-1A
6612


P55072_C522
VCP Transitional endoplasmic
6613



reticulum ATPase


P21333_C2293
FLNA Filamin-A
6614


Q15233_C208
NONO Non-POU domain-containing
6615



octamer-binding protein


P00492_C23
HPRT1 Hypoxanthine-guanine
6616



phosphoribosyltransferase


O94804_C873
STK10 Serine/threonine-protein kinase
6617



10


P36578_C96
RPL4 60S ribosomal protein L4
6618


P28838_C462
LAP3 Cytosol aminopeptidase
6619


P52272_C676
HNRNPM Heterogeneous nuclear
6620



ribonucleoprotein M


Q08AF3_C489
SLFN5 Schlafen family member 5
6621


Q9Y383_C59
LUC7L2 Putative RNA-binding protein
6622



Luc7-like 2


Q9NZ09_C45
UBAP1 Ubiquitin-associated protein 1
6623


Q14152_C404
EIF3A Eukaryotic translation initiation
6624



factor 3 subunit


Q99496_C72
RNF2 E3 ubiquitin-protein ligase
6625



RING2


P30086_C133
PEBP1 Phosphatidylethanolamine-
6626



binding protein 1


Q93009_C90
USP7 Ubiquitin carboxyl-terminal
6627



hydrolase 7


P83731_C36
RPL24 60S ribosomal protein L24
6628


P83731_C6
RPL24 60S ribosomal protein L24
6629


Q92499_C110
DDX1 ATP-dependent RNA helicase
6630



DDX1


A6NHR9_C492
SMCHD1 Structural maintenance of
6631



chromosomes flexible hinge domain



containing 1


P34932_C290
HSPA4 Heat shock 70 kDa protein 4
6632


Q9H4B7_C12
TUBB1 Tubulin beta-1 chain
6633


Q6PJG6_C326
BRAT1 BRCA1-associated ATM
6634



activator 1


Q9NZ08_C486
ERAP1 Endoplasmic reticulum
6635



aminopeptidase 1


Q5VZF2_C19
MBNL2 Muscleblind-like protein 2
6636


Q9NR56_C19
MBNL1 Muscleblind-like protein 1
6637


P55263_C353
ADK Adenosine kinase
6638


Q8WUM4_C40
PDCD61P Programmed cell death 6-
6639



interacting protein


P50579_C121
METAP2 Methionine aminopeptidase 2
6640


P21333_C1165
FLNA Filamin-A
6641


Q2M2I8_C288
AAK1 AP2-associated protein kinase 1
6642


Q8N0W3_C484
FUK L-fucose kinase
6643


P18621_C144
RPL17 60S ribosomal protein L17
6644


J3QL51_C144
RPL17-C18ORF32 Protein RPL17-
6645



C18ORF32


Q12906_C203
ILF3 Interleukin enhancer-binding
6646



factor 3


Q8N163_C754
KIAA1967 DBIRD complex subunit
6647



KIAA1967


Q6P1R4_C213
DUS1L tRNA-dihydrouridine(16/17)
6648



synthase


Q9Y490_C2196
TLN1 Talin-1
6649


Q92947_C176
GCDH Glutaryl-CoA dehydrogenase,
6650



mitochondrial


P21333_C1453
FLNA Filamin-A
6651


P49411_C147
TUFM Elongation factor Tu,
6652



mitochondrial


Q9BV38_C384
WDR18 WD repeat-containing protein
6653



18


Q93008_C1566
USP9X Probable ubiquitin carboxyl-
6654



terminal hydrolase FAF


O00507_C1568
USP9Y Probable ubiquitin carboxyl-
6655



terminal hydrolase FAF


Q9BXL7_C1115
CARD11 Caspase recruitment domain-
6656



containing protein 11


Q9P2J5_C573
LARS Leucine--tRNA ligase,
6657



cytoplasmic


O00541_C391
PES1 Pescadillo homolog
6658


Q9Y228_C388
TRAF3IP3 TRAF3-interacting JNK-
6659



activating modulator


O95747_C191
OXSR1 Serine/threonine-protein kinase
6660



OSR1


Q9UEW8_C237
STK39 STE20/SPS1-related proline-
6661



alanine-rich protein kinase


Q8IVH4_C184
MMAA Methylmalonic aciduria type A
6662



protein, mitochondrial


P49189_C484
ALDH9A1 4-
6663



trimethylaminobutyraldehyde



dehydrogenase


P08238_C521
HSP90AB1 Heat shock protein HSP
6664



90-beta


Q8TDP1_C34
RNASEH2C Ribonuclease H2 subunit
6665



C


P08575_C760
PTPRC Receptor-type tyrosine-protein
6666



phosphatase C


I3L3Q1_C558
Uncharacterized protein
6667


Q6ZSZ5_C600
ARHGEF18 Rho guanine nucleotide
6668



exchange factor 18


Q9Y490_C1661
TLN1 Talin-1
6669


Q9Y490_C1671
TLN1 Talin-1
6670


P53384_C235
NUBP1 Cytosolic Fe—S cluster
6671



assembly factor NUBP1


P49589_C204
CARS Cysteine--tRNA ligase,
6672



cytoplasmic


P78527_C2469
PRKDC DNA-dependent protein
6673



kinase catalytic subunit


Q9P2R3_C460
ANKFY1 Ankyrin repeat and FYVE
6674



domain-containing protein


P33316_C222
DUT Deoxyuridine 5-triphosphate
6675



nucleotidohydrolase, mitochondrial


E9PMF8_C694
PTPRC Receptor-type tyrosine-protein
6676



phosphatase C


P49773_C84
HINT1 Histidine triad nucleotide-
6677



binding protein 1


Q9BRZ2_C514
TRIM56 E3 ubiquitin-protein ligase
6678



TRIM56


P35754_C83
GLRX Glutaredoxin-1
6679


Q9Y490_C1353
TLN1 Talin-1
6680


P61981_C97
YWHAG 14-3-3 protein gamma
6681


Q15020_C341
SART3 Squamous cell carcinoma
6682



antigen recognized by T-cells 3


O60711_C199
LPXN Leupaxin
6683


Q9ULT8_C2415
HECTD1 E3 ubiquitin-protein ligase
6684



HECTD1


Q99757_C90
TXN2 Thioredoxin, mitochondrial
6685


Q99757_C93
TXN2 Thioredoxin, mitochondrial
6686


Q13363_C134
CTBP1 C-terminal-binding protein 1
6687


O95571_C34
ETHE1 Protein ETHE1, mitochondrial
6688


P31040_C311
SDHA Succinate dehydrogenase
6689


P29466_C285
CASP1 Caspase-1
6690


Q9Y4F9_C35
FAM65B Protein FAM65B
6691


P35754_C79
GLRX Glutaredoxin-1
6692


Q15149_C950
PLEC Plectin
6693


Q13642_C71
FHL1 Four and a half LIM domains
6694



protein 1


Q00610_C753
CLTC Clathrin heavy chain 1
6695


Q15365_C293
PCBP1 Poly(rC)-binding protein 1
6696


P39023_C253
RPL3 60S ribosomal protein L3
6697


Q96QR8_C238
PURB Transcriptional activator protein
6698



Pur-beta


P29590_C60
PML Protein PML
6699


P07814_C1497
EPRS Bifunctional glutamate/proline--
6700



tRNA ligase


Q9BYW2_C667
SETD2 Histone-lysine N-
6701



methyltransferase SETD2


Q13469_C569
NFATC2 Nuclear factor of activated T-
6702



cells, cytoplasmic 2


P31040_C305
SDHA Succinate dehydrogenase
6703


P40939_C550
HADHA Trifunctional enzyme subunit
6704



alpha, mitochondrial


P68104_C411
EEF1A1 Elongation factor 1-alpha 1
6705


Q15365_C158
PCBP1 Poly(rC)-binding protein 1
6706


P26599_C250
PTBP1 Polypyrimidine tract-binding
6707



protein 1


P26599_C251
PTBP1 Polypyrimidine tract-binding
6708



protein 1


P10768_C176
ESD S-formylglutathione hydrolase
6709


P10768_C181
ESD S-formylglutathione hydrolase
6710


P30084_C62
ECHS1 Enoyl-CoA hydratase,
6711



mitochondrial


Q15149_C3336
PLEC Plectin
6712


P51610_C149
HCFC1 Host cell factor 1
6713


Q9BUJ2_C291
HNRNPUL1 Heterogeneous nuclear
6714



ribonucleoprotein U-like protein


P11413_C385
G6PD Glucose-6-phosphate 1-
6715



dehydrogenase


P00488_C410
F13A1 Coagulation factor XIIIA chain
6716


Q9H8H3_C79
METTL7A Methyltransferase-like
6717



protein 7A


Q9NZ08_C498
ERAP1 Endoplasmic reticulum
6718



aminopeptidase 1


O00303_C256
EIF3F Eukaryotic translation initiation
6719



factor 3 subunit


O75643_C1127
SNRNP200 U5 small nuclear
6720



ribonucleoprotein 200 kDa helicas


Q5T4S7_C1274
UBR4 E3 ubiquitin-protein ligase
6721



UBR4


Q14676_C2049
MDC1 Mediator of DNA damage
6722



checkpoint protein 1


Q9Y2X3_C205
NOP58 Nucleolar protein 58
6723


P31930_C453
UQCRC1 Cytochrome b-c1 complex
6724



subunit 1, mitochondrial


Q15019_C111
SEPT2 Septin-2
6725


Q15149_C992
PLEC Plectin
6726


Q29RF7_C1079
PDS5A Sister chromatid cohesion
6727



protein PDS5 homolog A


Q6P2E9_C976
EDC4 Enhancer of mRNA-decapping
6728



protein 4


O00329_C474
PIK3CD Phosphatidylinositol 4,5-
6729



bisphosphate 3-kinase catalytic subunit



delta isoform


P56192_C12
MARS Methionine--tRNA ligase,
6730



cytoplasmic


P28838_C335
LAP3 Cytosol aminopeptidase
6731


P30876_C1093
POLR2B DNA-directed RNA
6732



polymerase II subunit RPB2


P27635_C195
RPL10 60S ribosomal protein L10
6733


Q9Y490_C1392
TLN1 Talin-1
6734


P55884_C384
EIF3B Eukaryotic translation initiation
6735



factor 3 subunit


Q9UGI8_C46
TES Testin
6736


P61978_C184
HNRNPK Heterogeneous nuclear
6737



ribonucleoprotein K


P31943_C122
HNRNPH1 Heterogeneous nuclear
6738



ribonucleoprotein H


Q63HN8_C4348
RNF213 E3 ubiquitin-protein ligase
6739



RNF213


Q9Y490_C956
TLN1 Talin-1
6740


P08133_C96
ANXA6 Annexin A6
6741


P13667_C206
PDLA4 Protein disulfide-isomerase A4
6742


Q7Z434_C33
MAVS Mitochondrial antiviral-
6743



signaling protein


Q9UKX7_C416
NUP50 Nuclear pore complex protein
6744



Nup50


Q2M2I8_C319
AAK1 AP2-associated protein kinase 1
6745


Q13547_C100
HDAC1 Histone deacetylase 1
6746


Q13547_C110
HDAC1 Histone deacetylase 1
6747


P13667_C209
PDIA4 Protein disulfide-isomerase A4
6748


P55795_C122
HNRNPH2 Heterogeneous nuclear
6749



ribonucleoprotein H2


O95544_C79
NADK NAD kinase
6750


P62140_C154
PPP1CB Serine/threonine-protein
6751



phosphatase PP1-beta catalytic subunit


P62136_C155
PPP1CA Serine/threonine-protein
6752



phosphatase PP1-alpha catalytic



subunit


P36873_C155
PPP1CC Serine/threonine-protein
6753



phosphatase PP1-gamma catalytic



subunit


P53597_C172
SUCLG1 Succinyl-CoA ligase
6754


O95071_C730
UBR5 E3 ubiquitin-protein ligase
6755



UBR5


P22314_C632
UBA1 Ubiquitin-like modifier-
6756



activating enzyme 1


Q9UBT2_C173
UBA2 SUMO-activating enzyme
6757



subunit 2


P55072_C572
VCP Transitional endoplasmic
6758



reticulum ATPase


O00329_C90
PIK3CD Phosphatidylinositol 4,5-
6759



bisphosphate 3-kinase catalytic subunit



delta isoform


Q9UGI8_C238
TES Testin
6760


Q14204_C2142
DYNC1H1 Cytoplasmic dynein 1
6761



heavy chain 1


Q9Y692_C113
GMEB1 Glucocorticoid modulatory
6762



element-binding protein


Q9UKD1_C110
GMEB2 Glucocorticoid modulatory
6763



element-binding protein


P43686_C210
PSMC4 26S protease regulatory
6764



subunit 6B


O95232_C58
LUC7L3 Luc7-like protein 3
6765


P27695_C99
APEX1 DNA-(apurinic or apyrimidinic
6766



site) lyase


P23743_C432
DGKA Diacylglycerol kinase alpha
6767


Q08J23_C93
NSUN2 tRNA (cytosine(34)-C(5))-
6768



methyltransferase


Q92616_C1482
GCN1L1 Translational activator GCN1
6769


Q9Y4B6_C1227
VPRBP Protein VPRBP
6770


Q9Y6D5_C1450
ARFGEF2 Brefeldin A-inhibited
6771



guanine nucleotide-exchange


Q6F5E8_C698
RLTPR Leucine-rich repeat-containing
6772



protein 16C


P21964_C119
COMT Catechol O-methyltransferase
6773


Q15365_C163
PCBP1 Poly(rC)-binding protein 1
6774


O14617_C208
AP3D1 AP-3 complex subunit delta-1
6775


P53597_C181
SUCLG1 Succinyl-CoA ligase
6776


P53582_C14
METAP1 Methionine aminopeptidase 1
6777


Q00839_C497
HNRNPU Heterogeneous nuclear
6778



ribonucleoprotein U


Q9Y6W5_C27
WASF2 Wiskott-Aldrich syndrome
6779



protein family member 2


Q99439_C164
CNN2 Calponin-2
6780


Q9NVG8_C145
TBC1D13 TBC1 domain family
6781



member 13


P10768_C56
ESD S-formylglutathione hydrolase
6782


P31146_C345
CORO1A Coronin-1A
6783


O75521_C380
ECI2 Enoyl-CoA delta isomerase 2,
6784



mitochondrial


P13796_C336
LCP1 Plastin-2
6785


Q15149_C4574
PLEC Plectin
6786


P98171_C569
ARHGAP4 Rho GTPase-activating
6787



protein 4


P48059_C272
LIMS1 LIM and senescent cell antigen-
6788



like-containing domain 1


Q86WV6_C257
TMEM173 Transmembrane protein
6789



173


P23743_C707
DGKA Diacylglycerol kinase alpha
6790


Q14204_C3573
DYNC1H1 Cytoplasmic dynein 1
6791



heavy chain 1


P22061_C95
PCMT1 Protein-L-isoaspartate(D-
6792



aspartate) O-methyltransferase


Q86W42_C35
THOC6 THO complex subunit 6
6793



homolog


P55072_C535
VCP Transitional endoplasmic
6794



reticulum ATPase


Q07666_C264
KHDRBS1 KH domain-containing,
6795



RNA-binding, signal transduction



associated 1


O00139_C334
KIF2A Kinesin-like protein KIF2A
6796


P30481_C188
HLA-B HLA class I histocompatibility
6797



antigen, B-44 alpha


P30483_C188
HLA-B HLA class I histocompatibility
6798



antigen, B-45 alpha


Q8WV92_C233
MITD1 MIT domain-containing protein
6799



1


P49207_C83
RPL34 60S ribosomal protein L34
6800


P24752_C119
ACAT1 Acetyl-CoA acetyltransferase,
6801



mitochondrial


P24752_C413
ACAT1 Acetyl-CoA acetyltransferase,
6802



mitochondrial


Q14141_C42
SEPT6 Septin-6
6803


O95319_C174
CELF2 CUGBP Elav-like family
6804



member 2


O15144_C120
ARPC2 Actin-related protein 2/3
6805



complex subunit 2


Q9NTK5_C55
OLA1 Obg-like ATPase 1
6806


Q9Y490_C1953
TLN1 Talin-1
6807


P42331_C258
ARHGAP25 Rho GTPase-activating
6808



protein 25


O75643_C1580
SNRNP200 U5 small nuclear
6809



ribonucleoprotein 200 kDa helicas


P27635_C49
RPL10 60S ribosomal protein L10
6810


P04075_C202
ALDOA Fructose-bisphosphate
6811



aldolase A


Q92616_C2255
GCN1L1 Translational activator GCN1
6812


Q15149_C3299
PLEC Plectin
6813


O94776_C209
MTA2 Metastasis-associated protein
6814



MTA2


O95466_C69
FMNL1 Formin-like protein 1
6815


P09972_C202
ALDOC Fructose-bisphosphate
6816



aldolase C


Q16186_C80
ADRM1 Proteasomal ubiquitin
6817



receptor ADRM1


Q9Y224_C19
C14orf166 UPF0568 protein
6818



C14orf166


P23743_C253
DGKA Diacylglycerol kinase alpha
6819


Q13464_C29
ROCK1 Rho-associated protein kinase
6820



1


O14617_C1133
AP3D1 AP-3 complex subunit delta-1
6821


P05062_C202
ALDOB Fructose-bisphosphate
6822



aldolase B


O95154_C186
AKR7A3 Aflatoxin B1 aldehyde
6823



reductase member 3


Q8NHP1_C186
AKR7L Aflatoxin B1 aldehyde
6824



reductase member 4


O43488_C214
AKR7A2 Aflatoxin B1 aldehyde
6825



reductase member 2


P23246_C431
SFPQ Splicing factor, proline- and
6826



glutamine-rich


O00268_C867
TAF4 Transcription initiation factor
6827



TFTTD subunit 4


P61158_C12
ACTR3 Actin-related protein 3
6828


P21333_C2601
FLNA Filamin-A
6829


O00567_C384
NOP56 Nucleolar protein 56
6830


P46776_C70
RPL27A 60S ribosomal protein L27a
6831


P68366_C54
TUBA4A Tubulin alpha-4A chain
6832


P68366_C295
TUBA4A Tubulin alpha-4A chain
6833


Q71U36_C295
TUBA1A Tubulin alpha-1A chain
6834


P62829_C125
RPL23 60S ribosomal protein L23
6835


O95881_C66
TXNDC12 Thioredoxin domain-
6836



containing protein 12


P50552_C64
VASP Vasodilator-stimulated
6837



phosphoprotein


Q9UJU6_C127
DBNL Drebrin-like protein
6838


Q9UNH7_C264
SNX6 Sorting nexin-6
6839


Q8WVJ2_C99
NUDCD2 NudC domain-containing
6840



protein 2


Q9Y490_C1486
TLN1 Talin-1
6841


Q8WYJ6_C231
SEPT1 Septin-1
6842


Q15149_C317
PLEC Plectin
6843


Q15027_C79
ACAP1 Arf-GAP with coiled-coil,
6844



ANK repeat and PH domain 1


Q9BXJ9_C322
NAA15 N-alpha-acetyltransferase 15,
6845



NatA auxiliary subunit


Q86YV0_C447
RASAL3 RAS protein activator like-3
6846


Q63HN8_C2918
RNF213 E3 ubiquitin-protein ligase
6847



RNF213


P61158_C8
ACTR3 Actin-related protein 3
6848


Q8WWQ0_C1144
PHIP PH-interacting protein
6849


Q9Y490_C1478
TLN1 Talin-1
6850


Q10567_C95
AP1B1 AP-1 complex subunit beta-1
6851


Q13748_C295
TUBA3D Tubulin alpha-3C/D chain
6852


Q8N1G4_C224
LRRC47 Leucine-rich repeat-
6853



containing protein 47


E9PPU0_C611
EPPK1 Epiplakin
6854


Q92878_C102
RAD50 DNA repair protein RAD50
6855


Q9UKE5_C202
TNIK TRAF2 and NCK-interacting
6856



protein kinase


Q96FV9_C445
THOC1 THO complex subunit 1
6857


Q92747_C162
ARPC1A Actin-related protein 2/3
6858



complex subunit 1A


O15143_C162
ARPC1B Actin-related protein 2/3
6859



complex subunit 1B


P12236_C160
SLC25A6 ADP/ATP translocase 3
6860


P05141_C160
SLC25A5 ADP/ATP translocase 2
6861


Q13315_C2021
ATM Serine-protein kinase ATM
6862


P50990_C244
CCT8 T-complex protein 1 subunit
6863



theta


Q00839_C607
HNRNPU Heterogeneous nuclear
6864



ribonucleoprotein U


P10809_C442
HSPD1 60 kDa heat shock protein,
6865



mitochondrial


Q676U5_C145
ATG16L1 Autophagy-related protein
6866



16-1


Q86UX7_C235
FERMT3 Fermitin family homolog 3
6867


P21333_C1353
FLNA Filamin-A
6868


Q56VL3_C27
OCIAD2 OCIA domain-containing
6869



protein 2


Q14204_C1977
DYNC1H1 Cytoplasmic dynein 1
6870



heavy chain 1


Q9NUV9_C187
GIMAP4 GTPase IMAP family
6871



member 4


P52272_C114
HNRNPM Heterogeneous nuclear
6872



ribonucleoprotein M


P78527_C3781
PRKDC DNA-dependent protein
6873



kinase catalytic subunit


P39023_C114
RPL3 60S ribosomal protein L3
6874


Q14202_C1326
ZMYM3 Zinc finger MYM-type
6875



protein 3


O43684_C129
BUB3 Mitotic checkpoint protein
6876



BUB3


Q8N2I2_C302
ZNF619 Zinc finger protein 619
6877


Q92900_C657
UPF1 Regulator of nonsense transcripts
6878



1


Q00839_C389
HNRNPU Heterogeneous nuclear
6879



ribonucleoprotein U


Q00839_C391
HNRNPU Heterogeneous nuclear
6880



ribonucleoprotein U


Q9Y3U8_C48
RPL36 60S ribosomal protein L36
6881


Q7L2J0_C177
MEPCE 7SK snRNA methylphosphate
6882



capping enzyme


Q01518_C93
CAP1 Adenylyl cyclase-associated
6883



protein 1


P55769_C30
NHP2L1 NHP2-like protein 1
6884


P46776_C144
RPL27A 60S ribosomal protein L27a
6885


Q9H3P7_C129
ACBD3 Golgi resident protein GCP60
6886


Q9NQR4_C153
NIT2 Omega-amidase NIT2
6887


O60216_C392
RAD21 Double-strand-break repair
6888



protein rad21 homolog


P13639_C67
EEF2 Elongation factor 2
6889


Q8WWP7_C76
GIMAP1 GTPase IMAP family
6890



member 1


Q9NTI5_C1069
PDS5B Sister chromatid cohesion
6891



protein PDS5 homolog B


P41091_C105
EIF2S3 Eukaryotic translation initiation
6892



factor 2 subunit


Q9Y2I8_C417
WDR37 WD repeat-containing protein
6893



37


P52566_C76
ARHGDIB Rho GDP-dissociation
6894



inhibitor 2


Q9BSJ8_C522
ESYT1 Extended synaptotagmin-1
6895


Q8N163_C238
KIAA1967 DBIRD complex subunit
6896



KIAA1967


Q92835_C672
INPP5D Phosphatidylinositol 3,4,5-
6897



trisphosphate 5-phosphatase


Q8NB90_C672
SPATA5 Spermatogenesis-associated
6898



protein 5


Q92878_C157
RAD50 DNA repair protein RAD50
6899


Q15370_C89
TCEB2 Transcription elongation factor
6900



B polypeptide 2


Q9UNF1_C516
MAGED2 Melanoma-associated
6901



antigen D2


Q08AF3_C48
SLFN5 Schlafen family member 5
6902


Q01082_C1900
SPTBN1 Spectrin beta chain, non-
6903



erythrocytic 1


Q8IUI8_C154
CRLF3 Cytokine receptor-like factor 3
6904


P57737_C505
CORO7 Coronin-7
6905


O95336_C237
PGLS 6-phosphogluconolactonase
6906


O15372_C327
EIF3H Eukaryotic translation initiation
6907



factor 3 subunit


Q63HN8_C3609
RNF213 E3 ubiquitin-protein ligase
6908



RNF213


P00367_C327
GLUD1 Glutamate dehydrogenase 1,
6909



mitochondrial


Q15185_C76
PTGES3 Prostaglandin E synthase 3
6910


Q86UX7_C439
FERMT3 Fermitin family homolog 3
6911


A6NHR9_C458
SMCHD1 Structural maintenance of
6912



chromosomes flexible hinge domain-



containing protein 1


P49448_C327
GLUD2 Glutamate dehydrogenase 2,
6913



mitochondrial


Q15052_C530
ARHGEF6 Rho guanine nucleotide
6914



exchange factor 6


H3BQZ7_C538
Uncharacterized protein
6915


Q1KMD3_C538
HNRNPUL2 Heterogeneous nuclear
6916



ribonucleoprotein U-like protein 2


P11413_C13
G6PD Glucose-6-phosphate 1-
6917



dehydrogenase


P57737_C34
CORO7 Coronin-7
6918


P55735_C187
SEC13 Protein SEC13 homolog
6919


P68366_C315
TUBA4A Tubulin alpha-4A chain
6920


P68366_C316
TUBA4A Tubulin alpha-4A chain
6921


Q71U36_C315
TUBA1A Tubulin alpha-1A chain
6922


Q71U36_C316
TUBA1A Tubulin alpha-1A chain
6923


P31146_C195
CORO1A Coronin-1A
6924


P68371_C354
TUBB4B Tubulin beta-4B chain
6925


P07437_C354
TUBB Tubulin beta chain
6926


P29350_C102
PTPN6 Tyrosine-protein phosphatase
6927



non-receptor type 6


P21333_C1260
FLNA Filamin-A
6928


P08670_C328
VIM Vimentin
6929


P42167_C363
TMPO Lamina-associated polypeptide
6930



2, isoforms beta/gamma


Q9H0C8_C325
ILKAP Integrin-linked kinase-
6931



associated serine/threonine


Q66K74_C342
MAP1S Microtubule-associated protein
6932



1S


Q7KZF4_C560
SND1 Staphylococcal nuclease
6933



domain-containing protein


Q9P1F3_C39
ABRACL Costars family protein
6934



ABRACL


P36507_C211
MAP2K2 Dual specificity mitogen-
6935



activated protein kinase


Q02750_C207
MAP2K1 Dual specificity mitogen-
6936



activated protein kinase


Q8NF50_C685
DOCK8 Dedicator of cytokinesis
6937



protein 8


Q9BVA1_C354
TUBB2B Tubulin beta-2B chain
6938


P36578_C125
RPL4 60S ribosomal protein L4
6939


Q8TD19_C890
NEK9 Serine/threonine-protein kinase
6940



Nek9


A6NHR9_C1286
SMCHD1 Structural maintenance of
6941



chromosomes flexible hinge domain-



containing protein 1


Q9BSD7_C110
NTPCR Cancer-related nucleoside-
6942



triphosphatase


Q14573_C1638
ITPR3 Inositol 1,4,5-trisphosphate
6943



receptor type 3


Q12874_C274
SF3A3 Splicing factor 3A subunit 3
6944


Q13045_C337
FLII Protein flightless-1 homolog
6945


Q8IY67_C255
RAVER1 Ribonucleoprotein PTB-
6946



binding 1


P13639_C728
EEF2 Elongation factor 2
6947


P53990_C125
IST1 IST1 homolog
6948


P13796_C618
LCP1 Plastin-2
6949


Q9BWM7_C193
SFXN3 Sideroflexin-3
6950


Q9H9B4_C190
SFXN1 Sideroflexin-1
6951


P31146_C192
CORO1A Coronin-1A
6952


Q15024_C85
EXOSC7 Exosome complex
6953



component RRP42


Q8N4C8_C202
MINK1 Misshapen-like kinase 1
6954


O95819_C202
MAP4K4 Mitogen-activated protein
6955



kinase kinase kinase kinase


P13798_C30
APEH Acylamino-acid-releasing
6956



enzyme


P35579_C172
MYH9 Myosin-9
6957


P30626_C194
SRI Sorcin
6958


O15371_C19
EIF3D Eukaryotic translation initiation
6959



factor 3 subunit


O00567_C211
NOP56 Nucleolar protein 56
6960


Q9UGI8_C196
TES Testin
6961


P67936_C247
TPM4 Tropomyosin alpha-4 chain
6962


P45954_C175
ACADSB Short/branched chain
6963



specific acyl-CoA dehydrogenase


Q14566_C301
MCM6 DNA replication licensing
6964



factor MCM6


P50990_C149
CCT8 T-complex protein 1 subunit
6965



theta


Q08945_C200
SSRP1 FACT complex subunit SSRP1
6966


P45985_C246
MAP2K4 Dual specificity mitogen-
6967



activated protein kinase


P21333_C2582
FLNA Filamin-A
6968


P29590_C213
PML Protein PML
6969


P13489_C30
RNH1 Ribonuclease inhibitor
6970


Q13315_C2770
ATM Serine-protein kinase ATM
6971


Q9NR56_C34
MBNL1 Muscleblind-like protein 1
6972


Q08AF3_C114
SLFN5 Schlafen family member 5
6973


Q53EL6_C150
PDCD4 Programmed cell death protein
6974



4


Q9NPJ6_C162
MED4 Mediator of RNA polymerase II
6975



transcription subunit


P25398_C92
RPS12 40S ribosomal protein S12
6976


P57737_C303
CORO7 Coronin-7
6977


Q96RL1_C283
UIMC1 BRCA1-A complex subunit
6978



RAP80


P24928_C1245
POLR2A DNA-directed RNA
6979



polymerase II subunit RPB1


P17858_C89
PFKL 6-phosphofructokinase, liver
6980



type


P50995_C226
ANXA11 Annexin A11
6981


Q7Z460_C1428
CLASP1 CLIP-associating protein 1
6982


O75122_C1184
CLASP2 CLIP-associating protein 2
6983


Q14008_C1344
CKAP5 Cytoskeleton-associated
6984



protein 5


Q14008_C1360
CKAP5 Cytoskeleton-associated
6985



protein 5


P16455_C145
MGMT Methylated-DNA--protein-
6986



cysteine methyltransferase


O14976_C190
GAK Cyclin-G-associated kinase
6987


Q14103_C226
HNRNPD Heterogeneous nuclear
6988



ribonucleoprotein D0


P11586_C918
MTHFD1 C-1-tetrahydrofolate
6989



synthase, cytoplasmic


Q14008_C1350
CKAP5 Cytoskeleton-associated
6990



protein 5


P42704_C484
LRPPRC Leucine-rich PPR motif-
6991



containing protein, mitochondrial


P50990_C148
CCT8 T-complex protein 1 subunit
6992



theta


P33992_C197
MCM5 DNA replication licensing
6993



factor MCM5


O43143_C190
DHX15 Putative pre-mRNA-splicing
6994



factor ATP-dependent RN


P07814_C381
EPRS Bifunctional glutamate/proline--
6995



tRNA ligase


P24928_C13
POLR2A DNA-directed RNA
6996



polymerase II subunit RPB1


P24928_C1287
POLR2A DNA-directed RNA
6997



polymerase II subunit RPB1


P42858_C664
HTT Huntingtin
6998


Q13155_C23
AIMP2 Aminoacyl tRNA synthase
6999



complex-interacting multif


Q14203_C1252
DCTN1 Dynactin subunit 1
7000


P68366_C347
TUBA4A Tubulin alpha-4A chain
7001


Q00839_C648
HNRNPU Heterogeneous nuclear
7002



ribonucleoprotein U


Q92616_C2558
GCN1L1 Translational activator GCN1
7003


Q86SX6_C67
GLRX5 Glutaredoxin-related protein 5,
7004



mitochondrial


P24752_C196
ACAT1 Acetyl-CoA acetyltransferase,
7005



mitochondrial


O75150_C950
RNF40 E3 ubiquitin-protein ligase
7006



BRE1B


P62979_C149
RPS27A Ubiquitin-40S ribosomal
7007



protein S27a


Q9Y3A3_C134
MOB4 MOB-like protein phocein
7008


Q8IUI8_C95
CRLF3 Cytokine receptor-like factor 3
7009


Q96SK2_C295
TMEM209 Transmembrane protein
7010



209


P21964_C238
COMT Catechol O-methyltransferase
7011


P62753_C100
RPS6 40S ribosomal protein S6
7012


Q9Y3Z3_C522
SAMHD1 SAM domain and HD
7013



domain-containing protein 1


Q12802_C2142
AKAP13 A-kinase anchor protein 13
7014


Q14697_C502
GANAB Neutral alpha-glucosidase AB
7015


P62826_C112
RAN GTP-binding nuclear protein Ran
7016


O15379_C94
HDAC3 Histone deacetylase 3
7017


P13010_C296
XRCC5 X-ray repair cross-
7018



complementing protein 5


Q9Y5Y2_C54
NUBP2 Cytosolic Fe—S cluster
7019



assembly factor NUBP2


Q9BRJ7_C171
NUDT16L1 Protein syndesmos
7020


P35579_C91
MYH9 Myosin-9
7021


P46940_C494
IQGAP1 Ras GTPase-activating-like
7022



protein IQGAP1


Q6F5E8_C823
RLTPR Leucine-rich repeat-containing
7023



protein 16C


Q8IX12_C465
CCAR1 Cell division cycle and
7024



apoptosis regulator protein 1


Q6F5E8_C582
RLTPR Leucine-rich repeat-containing
7025



protein 16C


Q13148_C198
TARDBP TAR DNA-binding protein
7026



43


Q9Y6N5_C337
SQRDL Sulfide:quinone
7027



oxidoreductase, mitochondrial


Q02880_C204
TOP2B DNA topoisomerase 2-beta
7028


P62826_C120
RAN GTP-binding nuclear protein Ran
7029


Q8NBN7_C30
RDH13 Retinol dehydrogenase 13
7030


P62979_C145
RPS27A Ubiquitin-40S ribosomal
7031



protein S27a


P41250_C471
GARS Glycine--tRNA ligase
7032


P46940_C781
IQGAP1 Ras GTPase-activating-like
7033



protein IQGAP1


P42765_C92
ACAA2 3-ketoacyl-CoA thiolase,
7034



mitochondrial


Q8WWP7_C186
GIMAP1 GTPase IMAP family
7035



member 1


P49207_C49
RPL34 60S ribosomal protein L34
7036


Q8IUI8_C313
CRLF3 Cytokine receptor-like factor 3
7037


P17655_C301
CAPN2 Calpain-2 catalytic subunit
7038


Q13526_C113
PIN1 Peptidyl-prolyl cis-trans
7039



isomerase NIMA-interacti


O60313_C375
OPA1 Dynamin-like 120 kDa protein,
7040



mitochondrial


P68371_C303
TUBB4B Tubulin beta-4B chain
7041


P07437_C303
TUBB Tubulin beta chain
7042


Q9UPN7_C37
PPP6R1 Serine/threonine-protein
7043



phosphatase 6 regulatory


Q96SW2_C188
CRBN Protein cereblon
7044


O14980_C1070
XPO1 Exportin-1
7045


Q15366_C109
PCBP2 Poly(rC)-binding protein 2
7046


P30154_C402
PPP2R1B Serine/threonine-protein
7047



phosphatase 2A 65 kDa regulatory



subunit A beta isoform


P30153_C390
PPP2R1A Serine/threonine-protein
7048



phosphatase 2A 65 kDa regulatory



subunit A alpha isoform


P07195_C294
LDHB L-lactate dehydrogenase B
7049



chain


P31943_C22
HNRNPH1 Heterogeneous nuclear
7050



ribonucleoprotein H


P53582_C40
METAP1 Methionine aminopeptidase 1
7051


P61221_C88
ABCE1 ATP-binding cassette sub-
7052



family E member 1


P49207_C46
RPL34 60S ribosomal protein L34
7053


P13639_C651
EEF2 Elongation factor 2
7054


Q9BVA1_C303
TUBB2B Tubulin beta-2B chain
7055


Q01082_C604
SPTBN1 Spectrin beta chain, non-
7056



erythrocytic 1


Q9Y490_C1045
TLN1 Talin-1
7057


Q15366_C158
PCBP2 Poly(rC)-binding protein 2
7058


O95573_C450
ACSL3 Long-chain-fatty-acid--CoA
7059



ligase 3


Q9BT78_C378
COPS4 COP9 signalosome complex
7060



subunit 4


Q53EL6_C288
PDCD4 Programmed cell death protein
7061



4


Q92841_C319
DDX17 Probable ATP-dependent RNA
7062



helicase DDX17


P49411_C127
TUFM Elongation factor Tu,
7063



mitochondrial


Q96P65_C201
QRFPR Pyroglutamylated RFamide
7064



peptide receptor


P46734_C227
MAP2K3 Dual specificity mitogen-
7065



activated protein kinase


P48643_C253
CCT5 T-complex protein 1 subunit
7066



epsilon


Q96GX9_C147
APIP Probable methylthioribulose-1-
7067



phosphate dehydratase


O00567_C112
NOP56 Nucleolar protein 56
7068


Q92835_C819
INPP5D Phosphatidylinositol 3,4,5-
7069



trisphosphate 5-phospha


P21333_C623
FLNA Filamin-A
7070


Q13509_C303
TUBB3 Tubulin beta-3 chain
7071


O60759_C210
CYTIP Cytohesin-interacting protein
7072


Q96P65_C200
QRFPR Pyroglutamylated RFamide
7073



peptide receptor


Q9BUF5_C303
TUBB6 Tubulin beta-6 chain
7074


O75369_C455
FLNB Filamin-B
7075


Q9UEY8_C245
ADD3 Gamma-adducin
7076


P06239_C465
LCK Tyrosine-protein kinase Lck
7077


P60953_C157
CDC42 Cell division control protein 42
7078



homolog


P11586_C863
MTHFD1 C-1-tetrahydrofolate
7079



synthase, cytoplasmic


Q71U36_C347
TUBA1A Tubulin alpha-1A chain
7080


P20073_C363
ANXA7 Annexin A7
7081


Q8WYJ6_C293
SEPT1 Septin-1
7082


P04406_C152
GAPDH Glyceraldehyde-3-phosphate
7083



dehydrogenase


P49748_C237
ACADVL Very long-chain specific
7084



acyl-CoA dehydrogenase,



mitochondrial


P53618_C635
COPB1 Coatomer subunit beta
7085


Q14669_C1538
TRIP12 E3 ubiquitin-protein ligase
7086



TRIP12


Q8WWP7_C98
GIMAP1 GTPase IMAP family
7087



member 1


P49840_C262
GSK3A Glycogen synthase kinase-3
7088



alpha


Q9UKV3_C1223
ACIN1 Apoptotic chromatin
7089



condensation inducer in the nucleus


Q8N5W9_C86
FAM101B Protein FAM101B
7090


P68371_C201
TUBB4B Tubulin beta-4B chain
7091


P68371_C211
TUBB4B Tubulin beta-4B chain
7092


Q9BVA1_C201
TUBB2B Tubulin beta-2B chain
7093


Q9BVA1_C211
TUBB2B Tubulin beta-2B chain
7094


P07437_C201
TUBB Tubulin beta chain
7095


P07437_C211
TUBB Tubulin beta chain
7096


Q8IV04_C305
TBC1D10C Carabin
7097


O60664_C341
PLIN3 Perilipin-3
7098


P53384_C277
NUBP1 Cytosolic Fe—S cluster
7099



assembly factor NUBP1


Q99439_C240
CNN2 Calponin-2
7100


P49841_C199
GSK3B Glycogen synthase kinase-3
7101



beta


P04406_C156
GAPDH Glyceraldehyde-3-phosphate
7102



dehydrogenase


O95758_C55
PTBP3 Polypyrimidine tract-binding
7103



protein 3


Q9NY65_C347
TUBA8 Tubulin alpha-8 chain
7104


Q13748_C347
TUBA3D Tubulin alpha-3C/D chain
7105


Q86WN1_C449
FCHSD1 FCH and double SH3
7106



domains protein 1


Q92619_C413
HMHA1 Minor histocompatibility
7107



protein HA-1


Q93009_C223
USP7 Ubiquitin carboxyl-terminal
7108



hydrolase 7


Q9BUF5_C201
TUBB6 Tubulin beta-6 chain
7109


Q9BUF5_C211
TUBB6 Tubulin beta-6 chain
7110


Q70J99_C136
UNC13D Protein unc-13 homolog D
7111


O95486_C704
SEC24A Protein transport protein
7112



Sec24A


P27987_C693
ITPKB Inositol-trisphosphate 3-kinase
7113



B


P84103_C6
SRSF3 Serine/arginine-rich splicing
7114



factor 3


P24752_C126
ACAT1 Acetyl-CoA acetyltransferase,
7115



mitochondrial


O00299_C223
CLIC1 Chloride intracellular channel
7116



protein 1


P68366_C376
TUBA4A Tubulin alpha-4A chain
7117


Q71U36_C376
TUBA1A Tubulin alpha-1A chain
7118


Q15365_C109
PCBP1 Poly(rC)-binding protein 1
7119


P62280_C60
RPS11 40S ribosomal protein S11
7120


P62829_C28
RPL23 60S ribosomal protein L23
7121


P05388_C119
RPLP0 60S acidic ribosomal protein P0
7122


P62937_C161
PPIA Peptidyl-prolyl cis-trans
7123



isomerase A


P28062_C120
PSMB8 Proteasome subunit beta type-8
7124


P28062_C124
PSMB8 Proteasome subunit beta type-8
7125


Q9Y228_C256
TRAF3IP3 TRAF3-interacting JNK-
7126



activating modulator


Q9BY49_C191
PECR Peroxisomal trans-2-enoyl-CoA
7127



reductase


P30154_C306
PPP2R1B Serine/threonine-protein
7128



phosphatase 2A 65 kDa regulatory



subunit A beta isoform


P30153_C294
PPP2R1A Serine/threonine-protein
7129



phosphatase 2A 65 kDa regulatory



subunit A alpha isoform


P52564_C196
MAP2K6 Dual specificity mitogen-
7130



activated protein kinase


P46734_C207
MAP2K3 Dual specificity mitogen-
7131



activated protein kinase


Q9NYL9_C150
TMOD3 Tropomodulin-3
7132


O75175_C600
CNOT3 CCR4-NOT transcription
7133



complex subunit 3


Q9H0D6_C736
XRN2 5-3 exoribonuclease 2
7134


Q8IV53_C52
DENND1C DENN domain-containing
7135



protein 1C


P26358_C1478
DNMT1 DNA (cytosine-5)-
7136



methyltransferase 1


Q7RTV0_C40
PHF5A PHD finger-like domain-
7137



containing protein 5A


P51570_C182
GALK1 Galactokinase
7138


Q9Y490_C1939
TLN1 Talin-1
7139


P49848_C460
TAF6 Transcription initiation factor
7140



TFIID subunit 6


Q9NY65_C376
TUBA8 Tubulin alpha-8 chain
7141


Q13748_C376
TUBA3D Tubulin alpha-3C/D chain
7142


Q9Y512_C457
SAMM50 Sorting and assembly
7143



machinery component 50 homolog


P40939_C470
HADHA Trifunctional enzyme subunit
7144



alpha, mitochondrial


Q6VY07_C732
PACS1 Phosphofurin acidic cluster
7145



sorting protein 1


Q9NWV8_C222
BABAM1 BRISC and BRCA1-A
7146



complex member 1


Q7KZF4_C152
SND1 Staphylococcal nuclease
7147



domain-containing protein


P12814_C480
ACTN1 Alpha-actinin-1
7148


P07900_C597
HSP90AA1 Heat shock protein HSP
7149



90-alpha


P07900_C598
HSP90AA1 Heat shock protein HSP
7150



90-alpha


H0Y2S0_C31
Uncharacterized protein
7151


Q6UB35_C906
MTHFD1L Monofunctional C1-
7152



tetrahydrofolate synthase,



mitochondrial


Q71UM5_C77
RPS27L 40S ribosomal protein S27-
7153



like


P42677_C77
RPS27 40S ribosomal protein S27
7154


Q08211_C1029
DHX9 ATP-dependent RNA helicase A
7155


O15533_C115
TAPBP Tapasin
7156


P29590_C389
PML Protein PML
7157


P62937_C62
PPIA Peptidyl-prolyl cis-trans
7158



isomerase A


Q14204_C1999
DYNC1H1 Cytoplasmic dynein 1
7159



heavy chain 1


Q13561_C240
DCTN2 Dynactin subunit 2
7160


Q13561_C256
DCTN2 Dynactin subunit 2
7161


H3BQZ7_C602
Uncharacterized protein
7162


Q1KMD3_C602
HNRNPUL2 Heterogeneous nuclear
7163



ribonucleoprotein U-like protein 2


P61247_C96
RPS3A 40S ribosomal protein S3a
7164


P68871_C94
HBB Hemoglobin subunit beta
7165


Q9UHD8_C375
SEPT9 Septin-9
7166


Q8NFW8_C394
CMAS N-acylneuraminate
7167



cytidylyltransferase


P51878_C315
CASP5 Caspase-5
7168


P49662_C258
CASP4 Caspase-4
7169


O75083_C170
WDR1 WD repeat-containing protein 1
7170


P55884_C515
EIF3B Eukaryotic translation initiation
7171



factor 3 subunit


Q9UKX7_C181
NUP50 Nuclear pore complex protein
7172



Nup50


Q13185_C69
CBX3 Chromobox protein homolog 3
7173


O00299_C59
CLIC1 Chloride intracellular channel
7174



protein 1


Q06587_C69
RING1 E3 ubiquitin-protein ligase
7175



RING1


Q14204_C3033
DYNC1H1 Cytoplasmic dynein 1
7176



heavy chain 1


Q13045_C241
FLII Protein flightless-1 homolog
7177


P48643_C181
CCT5 T-complex protein 1 subunit
7178



epsilon


Q04726_C528
TLE3 Transducin-like enhancer protein
7179



3


Q15149_C3493
PLEC Plectin
7180


O00299_C24
CLIC1 Chloride intracellular channel
7181



protein 1


P35579_C694
MYH9 Myosin-9
7182


Q9Y490_C732
TLN1 Talin-1
7183


Q8WWP7_C66
GIMAP1 GTPase IMAP family
7184



member 1


P49721_C91
PSMB2 Proteasome subunit beta type-2
7185


P52272_C653
HNRNPM Heterogeneous nuclear
7186



ribonucleoprotein M


Q9UK45_C85
LSM7 U6 snRNA-associated Sm-like
7187



protein LSm7


P21333_C2199
FLNA Filamin-A
7188


P22087_C268
FBL rRNA 2-O-methyltransferase
7189



fibrillarin


Q99714_C214
HSD17B10 3-hydroxyacyl-CoA
7190



dehydrogenase type-2


Q96F86_C413
EDC3 Enhancer of mRNA-decapping
7191



protein 3


P53621_C975
COPA Coatomer subunit alpha
7192


Q96S55_C272
WRNIP1 ATPase WRNIP1
7193


P15498_C652
VAV1 Proto-oncogene vav
7194


P53621_C453
COPA Coatomer subunit alpha
7195


Q96RU3_C248
FNBP1 Formin-binding protein 1
7196


Q13148_C39
TARDBP TAR DNA-binding protein
7197



43


Q9NYL9_C132
TMOD3 Tropomodulin-3
7198


Q5VWZ2_C12
LYPLAL1 Lysophospholipase-like
7199



protein 1


Q7Z5K2_C1170
WAPAL Wings apart-like protein
7200



homolog


Q13148_C244
TARDBP TAR DNA-binding protein
7201



43


Q13200_C779
PSMD2 26S proteasome non-ATPase
7202



regulatory subunit 2


Q99460_C806
PSMD1 26S proteasome non-ATPase
7203



regulatory subunit 1


P29466_C397
CASP1 Caspase-1
7204


P63279_C138
UBE2I SUMO-conjugating enzyme
7205



UBC9


Q92608_C1408
DOCK2 Dedicator of cytokinesis
7206



protein 2


Q9H6A0_C104
DENND2D DENN domain-containing
7207



protein 2D


Q96F86_C410
EDC3 Enhancer of mRNA-decapping
7208



protein 3


Q12824_C147
SMARCB1 SWI/SNF-related matrix-
7209



associated actin-dependent


O75427_C134
LRCH4 Leucine-rich repeat and
7210



calponin homology domain-containing



protein 4


Q08211_C438
DHX9 ATP-dependent RNA helicase A
7211


P11387_C630
TOP1 DNA topoisomerase 1
7212


A6NHR9_C985
SMCHD1 Structural maintenance of
7213



chromosomes flexible hinge domain



containing 1


P62195_C112
PSMC5 26S protease regulatory
7214



subunit 8


O43772_C58
SLC25A20 Mitochondrial
7215



carnitine/acylcarnitine carrier protein


Q71U36_C20
TUBA1A Tubulin alpha-1A chain
7216


Q15149_C3008
PLEC Plectin
7217


O75427_C224
LRCH4 Leucine-rich repeat and
7218



calponin homology domain-containing



protein 4


Q8N201_C1633
INTS1 Integrator complex subunit 1
7219


Q71U36_C25
TUBA1A Tubulin alpha-1A chain
7220


P07195_C164
LDHB L-lactate dehydrogenase B
7221



chain


P00338_C163
LDHA L-lactate dehydrogenase A
7222



chain


P21333_C1912
FLNA Filamin-A
7223


P21333_C1920
FLNA Filamin-A
7224


P00558_C379
PGK1 Phosphoglycerate kinase 1
7225


P19447_C342
ERCC3 TFIIH basal transcription
7226



factor complex helicase


P10809_C447
HSPD1 60 kDa heat shock protein,
7227



mitochondrial


P54198_C882
HIRA Protein HIRA
7228


P15153_C157
RAC2 Ras-related C3 botulinum toxin
7229



substrate 2


P53618_C623
COPB1 Coatomer subunit beta
7230


P07864_C163
LDHC L-lactate dehydrogenase C
7231



chain


Q6ZMR3_C163
LDHAL6A L-lactate dehydrogenase A-
7232



like 6A


P12268_C140
IMPDH2 Inosine-5-monophosphate
7233



dehydrogenase 2


Q69YN4_C353
KIAA1429 Protein virilizer homolog
7234


P00558_C380
PGK1 Phosphoglycerate kinase 1
7235


P15121_C299
AKR1B1 Aldose reductase
7236


Q92888_C892
ARHGEF1 Rho guanine nucleotide
7237



exchange factor 1


Q9BVQ7_C309
SPATA5L1 Spermatogenesis-
7238



associated protein 5-like protein


Q15149_C3110
PLEC Plectin
7239


P17655_C82
CAPN2 Calpain-2 catalytic subunit
7240


P50416_C304
CPT1A Carnitine O-
7241



palmitoyltransferase 1, liver isoform


Q92947_C289
GCDH Glutaryl-CoA dehydrogenase,
7242



mitochondrial


P60763_C157
RAC3 Ras-related C3 botulinum toxin
7243



substrate 3


P63000_C157
RAC1 Ras-related C3 botulinum toxin
7244



substrate 1


Q14141_C269
SEPT6 Septin-6
7245


Q6IBS0_C141
TWF2 Twinfilin-2
7246


P46736_C273
BRCC3 Lys-63-specific deubiquitinase
7247



BRCC36


O14641_C354
DVL2 Segment polarity protein
7248



dishevelled homolog DVL-2


Q13423_C936
NNT NAD(P) transhydrogenase,
7249



mitochondrial


Q15027_C320
ACAP1 Arf-GAP with coiled-coil,
7250



ANK repeat and PH domain 1


P22059_C224
OSBP Oxysterol-binding protein 1
7251


Q08945_C139
SSRP1 FACT complex subunit SSRP1
7252


P00558_C367
PGK1 Phosphoglycerate kinase 1
7253


P68366_C305
TUBA4A Tubulin alpha-4A chain
7254


Q71U36_C305
TUBA1A Tubulin alpha-1A chain
7255


P21333_C574
FLNA Filamin-A
7256


Q86XP3_C281
DDX42 ATP-dependent RNA helicase
7257



DDX42


Q9UL46_C91
PSME2 Proteasome activator complex
7258



subunit 2


Q92598_C34
HSPH1 Heat shock protein 105 kDa
7259


Q16186_C88
ADRM1 Proteasomal ubiquitin
7260



receptor ADRM1


P21333_C478
FLNA Filamin-A
7261


P21333_C483
FLNA Filamin-A
7262


P40926_C212
MDH2 Malate dehydrogenase,
7263



mitochondrial


P47756_C36
CAPZB F-actin-capping protein
7264



subunit beta


P12270_C1068
TPR Nucleoprotein TPR
7265


O43707_C499
ACTN4 Alpha-actinin-4
7266


Q5VSL9_C798
FAM40A Protein FAM40A
7267


P19367_C834
HK1 Hexokinase-1
7268


Q8N9T8_C673
KRI1 Protein KRI1 homolog
7269


P68371_C239
TUBB4B Tubulin beta-4B chain
7270


Q9BVA1_C239
TUBB2B Tubulin beta-2B chain
7271


P07437_C239
TUBB Tubulin beta chain
7272


P35579_C896
MYH9 Myosin-9
7273


Q9Y2H1_C235
STK38L Serine/threonine-protein
7274



kinase 38-like


Q15208_C234
STK38 Serine/threonine-protein kinase
7275



38


Q9UNM6_C357
PSMD13 26S proteasome non-ATPase
7276



regulatory subunit 13


Q8N8A2_C921
ANKRD44 Serine/threonine-protein
7277



phosphatase 6 regulatory


Q14669_C1959
TRIP12 E3 ubiquitin-protein ligase
7278



TRIP12


Q8IV53_C21
DENND1C DENN domain-containing
7279



protein 1C


Q86X10_C327
RALGAPB Ral GTPase-activating
7280



protein subunit beta


P0CB43_C368
FAM203B Protein FAM203B
7281


Q9Y490_C1434
TLN1 Talin-1
7282


O00499_C47
BIN1 Myc box-dependent-interacting
7283



protein 1


O15067_C66
PFAS
7284



Phosphoribosylfonnylglycinamidine



synthase


Q01082_C112
SPTBN1 Spectrin beta chain, non-
7285



erythrocytic 1


Q92793_C1219
CREBBP CREB-binding protein
7286


Q09472_C1183
EP300 Histone acetyltransferase p300
7287


Q16181_C126
SEPT7 Septin-7
7288


Q14289_C972
PTK2B Protein-tyrosine kinase 2-beta
7289


Q9H3P2_C131
WHSC2 Negative elongation factor A
7290


Q9H3P2_C141
WHSC2 Negative elongation factor A
7291


Q92570_C397
NR4A3 Nuclear receptor subfamily 4
7292



group A member 3


Q14204_C633
DYNC1H1 Cytoplasmic dynein 1
7293



heavy chain 1


P15880_C229
RPS2 40S ribosomal protein S2
7294


Q12906_C278
ILF3 Interleukin enhancer-binding
7295



factor 3


Q12906_C295
ILF3 Interleukin enhancer-binding
7296



factor 3


P27348_C237
YWHAQ 14-3-3 protein theta
7297


Q9UHD8_C531
SEPT9 Septin-9
7298


P16152_C227
CBR1 Carbonyl reductase
7299


P05455_C245
SSB Lupus La protein
7300


P50995_C294
ANXA11 Annexin A11
7301


P42765_C382
ACAA2 3-ketoacyl-CoA thiolase,
7302



mitochondrial


Q06323_C101
PSME1 Proteasome activator complex
7303



subunit 1


Q06323_C106
PSME1 Proteasome activator complex
7304



subunit 1


P68036_C86
UBE2L3 Ubiquitin-conjugating
7305



enzyme E2 L3


Q9P0J1_C151
PDP1
7306


Q92973_C285
TNPO1 Transportin-1
7307


Q86UX7_C128
FERMT3 Fermitin family homolog 3
7308


Q9Y5T5_C205
USP16 Ubiquitin carboxyl-terminal
7309



hydrolase 16


Q15149_C4071
PLEC Plectin
7310


Q9NP80_C714
PNPLA8 Calcium-independent
7311



phospholipase A2-gamma


P13796_C140
LCP1 Plastin-2
7312


O14647_C365
CHD2 Chromodomain-helicase-DNA-
7313



binding protein 2


Q92973_C297
TNPO1 Transportin-1
7314


P13489_C95
RNH1 Ribonuclease inhibitor
7315


P13489_C96
RNH1 Ribonuclease inhibitor
7316


Q9HC35_C820
EML4 Echinoderm microtubule-
7317



associated protein-like 4


P08107_C603
HSPA1B Heat shock 70 kDa protein
7318



1A/1B


P30510_C345
HLA-C HLA class I histocompatibility
7319



antigen, Cw-14 alph


Q29865_C345
HLA-C HLA class I histocompatibility
7320



antigen, Cw-18 alph


P30504_C345
HLA-C HLA class I histocompatibility
7321



antigen, Cw-4 alpha


Q00653_C432
NFKB2 Nuclear factor NF-kappa-B
7322



p100 subunit


Q96GX9_C16
APIP Probable methylthioribulose-1-
7323



phosphate dehydratase


P16152_C226
CBR1 Carbonyl reductase
7324


P13797_C143
PLS3 Plastin-3
7325


Q9TNN7_C345
HLA-C HLA class I histocompatibility
7326



antigen, Cw-5 alpha


Q29963_C345
HLA-C HLA class I histocompatibility
7327



antigen, Cw-6 alpha


Q29960_C345
HLA-C HLA class I histocompatibility
7328



antigen, Cw-16 alpha


Q07000_C345
HLA-C HLA class I histocompatibility
7329



antigen, Cw-15 alpha


P14678_C19
SNRPB Small nuclear
7330



ribonucleoprotein-associated protein


P63162_C19
SNRPN Small nuclear
7331



ribonucleoprotein-associated protein


O14950_C109
MYL12B Myosin regulatory light chain
7332



12B


P14618_C358
PKM Pyruvate kinase isozymes M1/M2
7333


O14733_C131
MAP2K7 Dual specificity mitogen-
7334



activated protein kinase


P62701_C41
RPS4X 40S ribosomal protein S4, X
7335



isoform


P60709_C257
ACTB Actin, cytoplasmic 1
7336


P60709_C272
ACTB Actin, cytoplasmic 1
7337


Q8N7H5_C36
PAF1 RNA polymerase II-associated
7338



factor 1 homolog


Q9UBB5_C359
MBD2 Methyl-CpG-binding domain
7339



protein 2


P21964_C223
COMT Catechol O-methyltransferase
7340


Q9BVQ7_C509
SPATA5L1 Spermatogenesis-
7341



associated protein 5-like protein


P61247_C201
RPS3A 40S ribosomal protein S3a
7342


Q9Y3D5_C90
MRPS18C 28S ribosomal protein S18c,
7343



mitochondrial


P48735_C308
IDH2 Isocitrate dehydrogenase
7344


P84243_C111
H3F3B Histone H3.3
7345


P37198_C475
NUP62 Nuclear pore glycoprotein p62
7346


P61158_C307
ACTR3 Actin-related protein 3
7347


P35754_C23
GLRX Glutaredoxin-1
7348


Q9Y5B9_C574
SUPT16H FACT complex subunit
7349



SPT16


P22102_C237
GART Trifunctional purine
7350



biosynthetic protein adenosine


Q01780_C612
EXOSC10 Exosome component 10
7351


Q7Z5K2_C293
WAPAL Wings apart-like protein
7352



homolog


P39687_C87
ANP32A Acidic leucine-rich nuclear
7353



phosphoprotein 32 family member A


P49588_C947
AARS Alanine--tRNA ligase,
7354



cytoplasmic


Q9GZR2_C382
REXO4 RNA exonuclease 4
7355


H3BQZ7_C408
Uncharacterized protein
7356


Q1KMD3_C408
HNRNPUL2 Heterogeneous nuclear
7357



ribonucleoprotein U-like protein 2


Q00325_C237
SLC25A3 Phosphate carrier protein,
7358



mitochondrial


Q8TEM1_C767
NUP210 Nuclear pore membrane
7359



glycoprotein 210


P62753_C12
RPS6 40S ribosomal protein S6
7360


O95487_C562
SEC24B Protein transport protein
7361



Sec24B


P17844_C200
DDX5 Probable ATP-dependent RNA
7362



helicase DDX5


Q92841_C277
DDX17 Probable ATP-dependent RNA
7363



helicase DDX17


O75533_C1035
SF3B1 Splicing factor 3B subunit 1
7364


P62280_C131
RPS11 40S ribosomal protein S11
7365


Q9Y3L3_C102
SH3BP1 SH3 domain-binding protein 1
7366


Q13148_C50
TARDBP TAR DNA-binding protein
7367



43


P14649_C89
MYL6B Myosin light chain 6B
7368


P60660_C32
MYL6 Myosin light polypeptide 6
7369


P62910_C91
RPL32 60S ribosomal protein L32
7370


P21333_C1157
FLNA Filamin-A
7371


Q9BWD1_C88
ACAT2 Acetyl-CoA acetyltransferase,
7372



cytosolic


Q9BWD1_C92
ACAT2 Acetyl-CoA acetyltransferase,
7373



cytosolic


Q8WWP7_C181
GIMAP1 GTPase IMAP family
7374



member 1


P05386_C61
RPLP1 60S acidic ribosomal protein P1
7375


P07900_C374
HSP90AA1 Heat shock protein HSP
7376



90-alpha


O75694_C974
NUP155 Nuclear pore complex protein
7377



Nup155


Q9NZ32_C388
ACTR10 Actin-related protein 10
7378


P14618_C326
PKM Pyruvate kinase isozymes M1/M2
7379


Q9BZL6_C217
PRKD2 Serine/threonine-protein kinase
7380



D2


Q9Y490_C709
TLN1 Talin-1
7381


Q9Y490_C719
TLN1 Talin-1
7382


A6NHR9_C505
SMCHD1 Structural maintenance of
7383



chromosomes flexible hinge domain-



containing protein 1


P18669_C153
PGAM1 Phosphoglycerate mutase 1
7384


Q99973_C149
TEP1 Telomerase protein component 1
7385


P31150_C202
GDI1 Rab GDP dissociation inhibitor
7386



alpha


Q96S15_C474
WDR24 WD repeat-containing protein
7387



24


A0FGR8_C611
ESYT2 Extended synaptotagmin-2
7388


P49792_C348
RANBP2 E3 SUMO-protein ligase
7389



RanBP2


Q9Y6C9_C79
MTCH2 Mitochondrial carrier homolog
7390



2


Q9Y3L3_C388
SH3BP1 SH3 domain-binding protein 1
7391


P47755_C111
CAPZA2 F-actin-capping protein
7392



subunit alpha-2


Q86W42_C314
THOC6 THO complex subunit 6
7393



homolog


P38646_C317
HSPA9 Stress-70 protein,
7394



mitochondrial


Q9U1D3_C190
VPS51 Vacuolar protein sorting-
7395



associated protein 51 homolog


Q9Y2Q3_C176
GSTK1 Glutathione S-transferase
7396



kappa 1


Q86XR8_C285
CEP57 Centrosomal protein of 57 kDa
7397


P21281_C162
ATP6V1B2 V-type proton ATPase
7398



subunit B, brain isoform


Q86UV5_C39
USP48 Ubiquitin carboxyl-terminal
7399



hydrolase 48


P35579_C671
MYH9 Myosin-9
7400


P10809_C237
HSPD1 60 kDa heat shock protein,
7401



mitochondrial


P35611_C68
ADD1 Alpha-adducin
7402


Q9H4M9_C138
EHD1 EH domain-containing protein 1
7403


O60828_C60
PQBP1 Polyglutamine-binding protein
7404



1


Q9P289_C392
MST4 Serine/threonine-protein kinase
7405



MST4


P28838_C376
LAP3 Cytosol aminopeptidase
7406


P55265_C851
ADAR Double-stranded RNA-specific
7407



adenosine deaminase


Q8WXH0_C39
SYNE2 Nesprin-2
7408


P50991_C252
CCT4 T-complex protein 1 subunit
7409



delta


Q8NDH3_C189
NPEPL1 Probable aminopeptidase
7410



NPEPL1


P49023_C290
PXN Paxillin
7411


Q9Y508_C8
RNF114 RING finger protein 114
7412


P13667_C555
PDIA4 Protein disulfide-isomerase A4
7413


P30101_C406
PDIA3 Protein disulfide-isomerase A3
7414


P15153_C6
RAC2 Ras-related C3 botulinum toxin
7415



substrate 2


Q29RF7_C583
PDS5A Sister chromatid cohesion
7416



protein PDS5 homolog A


Q00839_C408
HNRNPU Heterogeneous nuclear
7417



ribonucleoprotein U


P13667_C558
PDIA4 Protein disulfide-isomerase A4
7418


P30101_C409
PDIA3 Protein disulfide-isomerase A3
7419


Q9Y4H4_C160
GPSM3 G-protein-signaling modulator
7420



3


P60763_C6
RAC3 Ras-related C3 botulinum toxin
7421



substrate 3


P63000_C6
RAC1 Ras-related C3 botulinum toxin
7422



substrate 1


O95232_C40
LUC7L3 Luc7-like protein 3
7423


P60953_C6
CDC42 Cell division control protein 42
7424



homolog


P61158_C34
ACTR3 Actin-related protein 3
7425


Q9P2A4_C137
ABI3 ABI gene family member 3
7426


P16333_C266
NCK1 Cytoplasmic protein NCK1
7427


P49591_C438
SARS Serine--tRNA ligase,
7428



cytoplasmic


Q9BQC3_C251
DPH2 Diphthamide biosynthesis
7429



protein 2


Q99439_C61
CNN2 Calponin-2
7430


Q07020_C134
RPL18 60S ribosomal protein L18
7431


P57772_C442
EEFSEC Selenocysteine-specific
7432



elongation factor


Q92797_C848
SYMPK Symplekin
7433


Q8WUM4_C250
PDCD6IP Programmed cell death 6-
7434



interacting protein


P04075_C73
ALDOA Fructose-bisphosphate
7435



aldolase A


P31146_C51
CORO1A Coronin-1A
7436


P31146_C24
CORO1A Coronin-1A
7437


Q9NXE8_C107
CWC25 Pre-mRNA-splicing factor
7438



CWC25 homolog


Q01813_C360
PFKP 6-phosphofructokinase type C
7439


Q92878_C1302
RAD50 DNA repair protein RAD50
7440


P62241_C174
RPS8 40S ribosomal protein S8
7441


Q9BQC3_C250
DPH2 Diphthamide biosynthesis
7442



protein 2


Q14166_C612
TTLL12 Tubulin--tyrosine ligase-like
7443



protein 12


P62241_C72
RPS8 40S ribosomal protein S8
7444


P28062_C160
PSMB8 Proteasome subunit beta type-8
7445


P51649_C340
ALDH5A1 Succinate-semialdehyde
7446



dehydrogenase, mitochondrial


Q8WYJ6_C99
SEPT1 Septin-1
7447


Q8WYJ6_C102
SEPT1 Septin-1
7448


Q15027_C64
ACAP1 Arf-GAP with coiled-coil,
7449



ANK repeat and PH domain 1


Q15366_C54
PCBP2 Poly(rC)-binding protein 2
7450


Q15365_C54
PCBP1 Poly(rC)-binding protein 1
7451


P35236_C204
PTPN7 Tyrosine-protein phosphatase
7452



non-receptor type 7


P47756_C147
CAPZB F-actin-capping protein
7453



subunit beta


A6NHR9_C444
SMCHD1 Structural maintenance of
7454



chromosomes flexible hinge domain-



containing protein 1


Q5TDH0_C361
DDI2 Protein DDI1 homolog 2
7455


P62266_C90
RPS23 40S ribosomal protein S23
7456


P29590_C204
PML Protein PML
7457


P42226_C228
STAT6 Signal transducer and activator
7458



of transcription 6


Q9H1E5_C326
TMX4 Thioredoxin-related
7459



transmembrane protein 4


P62241_C71
RPS8 40S ribosomal protein S8
7460


Q9UBW5_C205
BIN2 Bridging integrator 2
7461


P41214_C489
EIF2D Eukaryotic translation initiation
7462



factor 2D


Q96I99_C255
SUCLG2 Succinyl-CoA ligase
7463


P63208_C160
SKP1 S-phase kinase-associated
7464



protein 1


P61163_C34
ACTR1A Alpha-centractin
7465


P42025_C34
ACTR1B Beta-centractin
7466


O15381_C626
NVL Nuclear valosin-containing
7467



protein-like


Q9NTX5_C133
ECHDC1 Ethylmalonyl-CoA
7468



decarboxylase


O43390_C292
HNRNPR Heterogeneous nuclear
7469



ribonucleoprotein R


O60506_C289
SYNCRIP Heterogeneous nuclear
7470



ribonucleoprotein Q


Q2M2I8_C156
AAK1 AP2-associated protein kinase 1
7471


P62917_C115
RPL8 60S ribosomal protein L8
7472


O60610_C314
DIAPH1 Protein diaphanous homolog 1
7473


P12081_C455
HARS Histidine--tRNA ligase,
7474



cytoplasmic


P62917_C114
RPL8 60S ribosomal protein L8
7475


P23528_C147
CFL1 Cofilin-1
7476


P49189_C288
ALDH9A1 4-
7477



trimethylaminobutyraldehyde



dehydrogenase


P49189_C289
ALDH9A1 4-
7478



trimethylaminobutyraldehyde



dehydrogenase


Q8N0W3_C582
FUK L-fucose kinase
7479


Q14137_C404
BOP1 Ribosome biogenesis protein
7480



BOP1


Q9Y4K1_C1404
AIM1 Absent in melanoma 1 protein
7481


P19367_C813
HK1 Hexokinase-1
7482


P60174_C79
TPI1 Triosephosphate isomerase
7483


Q9H307_C249
PNN Pinin
7484


Q9UKA8_C239
RCAN3 Calcipressin-3
7485


O00160_C101
MYO1F Unconventional myosin-If
7486


P07355_C133
ANXA2 Annexin A2
7487


P07814_C1148
EPRS Bifunctional glutamate/proline--
7488



tRNA ligase


P52907_C157
CAPZA1 F-actin-capping protein
7489



subunit alpha-1


P62837_C111
UBE2D2 Ubiquitin-conjugating
7490



enzyme E2 D2


P61077_C111
UBE2D3 Ubiquitin-conjugating
7491



enzyme E2 D3


Q8NE71_C365
ABCF1 ATP-binding cassette sub-
7492



family F member 1


Q8NBU5_C359
ATAD1 ATPase family AAA domain-
7493



containing protein 1


P55265_C630
ADAR Double-stranded RNA-specific
7494



adenosine deaminase


Q9Y3Z3_C51
SAMHD1 SAM domain and HD
7495



domain-containing protein 1


P29728_C668
OAS2 2-5-oligoadenylate synthase 2
7496


O43823_C85
AKAP8 A-kinase anchor protein 8
7497


P51610_C135
HCFC1 Host cell factor 1
7498


P20592_C100
MX2 Interferon-induced GTP-binding
7499



protein Mx2


Q96N96_C124
SPATA13 Spermatogenesis-associated
7500



protein 13


Q01826_C209
SATB1 DNA-binding protein SATB1
7501


I3L1I5_C86
Uncharacterized protein
7502


P62837_C107
UBE2D2 Ubiquitin-conjugating
7503



enzyme E2 D2


P61077_C107
UBE2D3 Ubiquitin-conjugating
7504



enzyme E2 D3


P20591_C52
MX1 Interferon-induced GTP-binding
7505



protein Mx1


Q9Y490_C1023
TLN1 Talin-1
7506


Q99973_C1468
TEP1 Telomerase protein component 1
7507


Q8IY67_C297
RAVER1 Ribonucleoprotein PTB-
7508



binding 1


Q8WUM4_C512
PDCD6IP Programmed cell death 6-
7509



interacting protein


Q14141_C14
SEPT6 Septin-6
7510


O15213_C172
WDR46 WD repeat-containing protein
7511



46


B0I1T2_C143
MYO1G Unconventional myosin-Ig
7512


P14868_C349
DARS Aspartate--tRNA ligase,
7513



cytoplasmic


P40227_C406
CCT6A T-complex protein 1 subunit
7514



zeta


Q29RF7_C327
PDS5A Sister chromatid cohesion
7515



protein PDS5 homolog A


Q8NF50_C170
DOCK8 Dedicator of cytokinesis
7516



protein 8


Q14683_C1115
SMC1A Structural maintenance of
7517



chromosomes protein 1A


O14773_C522
TPP1 Tripeptidyl-peptidase 1
7518


O14773_C526
TPP1 Tripeptidyl-peptidase 1
7519


O14773_C537
TPP1 Tripeptidyl-peptidase 1
7520


Q9NTI5_C317
PDS5B Sister chromatid cohesion
7521



protein PDS5 homolog B


Q9NVP1_C183
DDX18 ATP-dependent RNA helicase
7522



DDX18


Q9Y490_C1506
TLN1 Talin-1
7523


P13796_C164
LCP1 Plastin-2
7524


Q5EBM0_C287
CMPK2 UMP-CMP kinase 2,
7525



mitochondrial


Q08AF3_C875
SLFN5 Schlafen family member 5
7526


Q9NUV9_C220
GIMAP4 GTPase IMAP family
7527



member 4


P08238_C589
HSP90AB1 Heat shock protein HSP
7528



90-beta


P08238_C590
HSP90AB1 Heat shock protein HSP
7529



90-beta


P60866_C70
RPS20 40S ribosomal protein S20
7530


Q08J23_C673
NSUN2 tRNA (cytosine(34)-C(5))-
7531



methyltransferase


Q9H4E7_C253
DEF6 Differentially expressed in FDCP
7532



6 homolog


Q15365_C194
PCBP 1 Poly(rC)-binding protein 1
7533


P30041_C47
PRDX6 Peroxiredoxin-6
7534


P78371_C395
CCT2 T-complex protein 1 subunit beta
7535


P46782_C155
RPS5 40S ribosomal protein S5
7536


Q96GM5_C492
SMARCD1 SWI/SNF-related matrix-
7537



associated actin-dependent


P10599_C73
TXN Thioredoxin
7538


Q14258_C70
TRIM25 E3 ubiquitin/ISG15 ligase
7539



TRIM25


Q96RN5_C618
MED15 Mediator of RNA polymerase
7540



II transcription subuni


P45973_C133
CBX5 Chromobox protein homolog 5
7541


Q9UHD8_C248
SEPT9 Septin-9
7542


P39023_C336
RPL3 60S ribosomal protein L3
7543


O14980_C164
XPO1 Exportin-1
7544


Q08J23_C678
NSUN2 tRNA (cytosine(34)-C(5))-
7545



methyltransferase


Q00839_C562
HNRNPU Heterogeneous nuclear
7546



ribonucleoprotein U


Q9BVA1_C127
TUBB2B Tubulin beta-2B chain
7547


Q9BVA1_C129
TUBB2B Tubulin beta-2B chain
7548


P10599_C32
TXN Thioredoxin
7549


Q14289_C677
PTK2B Protein-tyrosine kinase 2-beta
7550


Q9H4E7_C244
DEF6 Differentially expressed in FDCP
7551



6 homolog


P15311_C117
EZR Ezrin
7552


P55060_C387
CSE1L Exportin-2
7553


Q13838_C165
DDX39B Spliceosome RNA helicase
7554



DDX39B


A6NE09_C163
RPSAP58 Protein RPSAP58
7555


Q9BTZ2_C209
DHRS4 Dehydrogenase/reductase SDR
7556



family member 4


Q8IY21_C517
DDX60 Probable ATP-dependent RNA
7557



helicase DDX60


P04075_C339
ALDOA Fructose-bisphosphate
7558



aldolase A


P13639_C466
EEF2 Elongation factor 2
7559


Q99832_C29
CCT7 T-complex protein 1 subunit eta
7560


P12814_C332
ACTN1 Alpha-actinin-1
7561


Q92619_C278
HMHA1 Minor histocompatibility
7562



protein HA-1


Q13131_C185
PRKAA1 5-AMP-activated protein
7563



kinase catalytic subunit


P54646_C174
PRKAA2 5-AMP-activated protein
7564



kinase catalytic subunit


Q00610_C926
CLTC Clathrin heavy chain 1
7565


Q00610_C934
CLTC Clathrin heavy chain 1
7566


Q99439_C175
CNN2 Calponin-2
7567


B0I1T2_C965
MYO1G Unconventional myosin-Ig
7568


Q02252_C317
ALDH6A1 Methylmalonate-
7569



semialdehyde dehydrogenase


P12955_C467
PEPD Xaa-Pro dipeptidase
7570


P08238_C366
HSP90AB1 Heat shock protein HSP
7571



90-beta


P13639_C369
EEF2 Elongation factor 2
7572


P41240_C31
CSK Tyrosine-protein kinase CSK
7573


P13639_C812
EEF2 Elongation factor 2
7574


P22736_C551
NR4A1 Nuclear receptor subfamily 4
7575



group A member 1


Q8WVV9_C84
HNRPLL Heterogeneous nuclear
7576



ribonucleoprotein L-like


O43707_C351
ACTN4 Alpha-actinin-4
7577


Q9H4B7_C340
TUBB1 Tubulin beta-1 chain
7578


O15067_C270
PFAS
7579



Phosphoribosylformylglycinamidine



synthase


Q13045_C232
FLII Protein flightless-1 homolog
7580


Q13057_C144
COASY Bifunctional coenzyme A
7581



synthase


P43243_C230
MATR3 Matrin-3
7582


A5YKK6_C624
CNOT1 CCR4-NOT transcription
7583



complex subunit 1


Q9Y6D5_C76
ARFGEF2 Brefeldin A-inhibited
7584



guanine nucleotide-exchange


P49915_C489
GMPS GMP synthase
7585


Q96BN8_C347
FAM105B Protein FAM105B
7586


P43403_C78
ZAP70 Tyrosine-protein kinase ZAP-
7587



70


Q9Y3D0_C158
FAM96B Mitotic spindle-associated
7588



MMXD complex subunit MI


Q03518_C795
TAP1 Antigen peptide transporter 1
7589


Q86WS5_C64
TMPRSS12 Transmembrane protease
7590



serine 12


P50579_C298
METAP2 Methionine aminopeptidase 2
7591


Q14019_C52
COTL1 Coactosin-like protein
7592


P34897_C119
SHMT2 Serine
7593



hydroxymethyltransferase,



mitochondrial


Q86YV9_C695
HPS6 Hermansky-Pudlak syndrome 6
7594



protein


Q96FX7_C209
TRMT61A tRNA (adenine(58)-N(1))-
7595



methyltransferase catalytic


P23528_C139
CFL1 Cofilin-1
7596


Q96F15_C238
GIMAP5 GTPase IMAP family
7597



member 5


P62888_C92
RPL30 60S ribosomal protein L30
7598


Q8N163_C644
KIAA1967 DBIRD complex subunit
7599



KIAA1967


Q9C0K0_C642
BCL11B B-cell lymphoma/leukemia
7600



11B


P53618_C888
COPB1 Coatomer subunit beta
7601


P13639_C751
EEF2 Elongation factor 2
7602


P60763_C178
RAC3 Ras-related C3 botulinum toxin
7603



substrate 3


P63000_C178
RAC1 Ras-related C3 botulinum toxin
7604



substrate 1


P38606_C254
ATP6V1A V-type proton ATPase
7605



catalytic subunit A


Q14683_C987
SMC1A Structural maintenance of
7606



chromosomes protein 1A


P23528_C39
CFL1 Cofilin-1
7607


P17987_C147
TCP1 T-complex protein 1 subunit
7608



alpha


P31946_C96
YWHAB 14-3-3 protein beta/alpha
7609


Q63HN8_C1748
RNF213 E3 ubiquitin-protein ligase
7610



RNF213


P46782_C172
RPS5 40S ribosomal protein S5
7611


O00483_C44
NDUFA4 NADH dehydrogenase
7612


P50570_C27
DNM2 Dynamin-2
7613


O75427_C179
LRCH4 Leucine-rich repeat and
7614



calponin homology domain-containing



protein 4


P22234_C81
PAICS Multifunctional protein ADE2
7615


P34932_C34
HSPA4 Heat shock 70 kDa protein 4
7616


H3BQZ7_C452
Uncharacterized protein
7617


Q1KMD3_C452
HNKNPUL2 Heterogeneous nuclear
7618



ribonucleoprotein U-like protein 2


P62837_C85
UBE2D2 Ubiquitin-conjugating
7619



enzyme E2 D2


P61077_C85
UBE2D3 Ubiquitin-conjugating
7620



enzyme E2 D3


P52565_C79
ARHGDIA Rho GDP-dissociation
7621



inhibitor 1


Q9HCD5_C137
NCOA5 Nuclear receptor coactivator 5
7622


O14733_C260
MAP2K7 Dual specificity mitogen-
7623



activated protein kinase


Q14203_C791
DCTN1 Dynactin subunit 1
7624


Q96JM7_C682
L3MBTL3 Lethal(3)malignant brain
7625



tumor-like protein 3


O14773_C365
TPP1 Tripeptidyl-peptidase 1
7626


P61158_C408
ACTR3 Actin-related protein 3
7627


P45974_C532
USP5 Ubiquitin carboxyl-terminal
7628



hydrolase 5


P23368_C120
ME2 NAD-dependent malic enzyme,
7629



mitochondrial


P60903_C62
S100A10 Protein S100-A10
7630


Q07955_C148
SRSF1 Serine/arginine-rich splicing
7631



factor 1


P10644_C18
PRKAR1A cAMP-dependent protein
7632



kinase type I-alpha regulatory subunit


P07814_C692
EPRS Bifunctional glutamate/proline--
7633



tRNA ligase


O15355_C13
PPM1G Protein phosphatase 1G
7634


P08133_C669
ANXA6 Annexin A6
7635


P22314_C1039
UBA1 Ubiquitin-like modifier-
7636



activating enzyme 1


Q00839_C594
HNRNPU Heterogeneous nuclear
7637



ribonucleoprotein U


O14980_C34
XPO1 Exportin-1
7638


O43290_C645
SART1 U4/U6.U5 tri-snRNP-
7639



associated protein 1


Q9Y5Y2_C72
NUBP2 Cytosolic Fe—S cluster
7640



assembly factor NUBP2


Q15365_C201
PCBP1 Poly(rC)-binding protein 1
7641


P30086_C168
PEBP1 Phosphatidylethanolamine-
7642



binding protein 1


P11142_C17
HSPA8 Heat shock cognate 71 kDa
7643



protein


O60496_C110
DOK2 Docking protein 2
7644


P85037_C254
FOXK1 Forkhead box protein K1
7645


P54577_C250
YARS Tyrosine--tRNA ligase,
7646



cytoplasmic


Q8IX01_C656
SUGP2 SURP and G-patch domain-
7647



containing protein 2


P22314_C1040
UBA1 Ubiquitin-like modifier-
7648



activating enzyme 1


Q709C8_C2177
VPS13C Vacuolar protein sorting-
7649



associated protein 13C


Q709C8_C2440
VPS13C Vacuolar protein sorting-
7650



associated protein 13C


P61158_C189
ACTR3 Actin-related protein 3
7651


P0CW22_C35
RPS17L 40S ribosomal protein S17-
7652



like


Q6KC79_C1795
NIPBL Nipped-B-like protein
7653


Q15042_C322
RAB3GAP1 Rab3 GTPase-activating
7654



protein catalytic subunit


P60709_C285
ACTB Actin, cytoplasmic 1
7655


P04899_C112
GNAI2 Guanine nucleotide-binding
7656



protein G(i) subunit al


P23396_C97
RPS3 40S ribosomal protein S3
7657


P00558_C316
PGK1 Phosphoglycerate kinase 1
7658


P39687_C123
ANP32A Acidic leucine-rich nuclear
7659



phosphoprotein 32 family member A


P27708_C1889
CAD CAD protein
7660


Q15646_C188
OASL 2-5-oligoadenylate synthase-like
7661



protein


Q9ULA0_C413
DNPEP Aspartyl aminopeptidase
7662


Q9HAU5_C578
UPF2 Regulator of nonsense transcripts
7663



2


P50995_C384
ANXA11 Annexin A11
7664


P63220_C17
RPS21 40S ribosomal protein S21
7665


Q16822_C306
PCK2 Phosphoenolpyruvate
7666



carboxykinase


P14921_C31
ETS1 Protein C-ets-1
7667


Q9BWU1_C349
CDK19 Cyclin-dependent kinase 19
7668


P60174_C164
TPI1 Triosephosphate isomerase
7669


P55809_C67
OXCT1 Succinyl-CoA:3-ketoacid
7670



coenzyme A transferase 1,


P54136_C369
RARS Arginine--tRNA ligase,
7671



cytoplasmic


O60784_C415
TOM1 Target of Myb protein 1
7672


Q16630_C159
CPSF6 Cleavage and polyadenylation
7673



specificity factor subunit 6


Q13370_C410
PDE3B cGMP-inhibited 3,5-cyclic
7674



phosphodiesterase B


P68104_C234
EEF1A1 Elongation factor 1-alpha 1
7675


P62937_C115
PPIA Peptidyl-prolyl cis-trans
7676



isomerase A


O75390_C211
CS Citrate synthase, mitochondrial
7677


Q92688_C123
ANP32B Acidic leucine-rich nuclear
7678



phosphoprotein 32 family member A


A6NHR9_C1656
SMCHD1 Structural maintenance of
7679



chromosomes flexible hinge domain-



containing protein 1


Q3B7J2_C377
GFOD2 Glucose-fructose
7680



oxidoreductase domain-containing


O15523_C296
DDX3Y ATP-dependent RNA helicase
7681



DDX3Y


O00571_C298
DDX3X ATP-dependent RNA helicase
7682



DDX3X


P61158_C235
ACTR3 Actin-related protein 3
7683


Q53EL6_C275
PDCD4 Programmed cell death protein
7684



4


P05388_C27
RPLP0 60S acidic ribosomal protein P0
7685


Q96I99_C162
SUCLG2 Succinyl-CoA ligase
7686


P08133_C114
ANXA6 Annexin A6
7687


P09104_C389
ENO2 Gamma-enolase
7688


P06733_C389
ENO1 Alpha-enolase
7689


P13929_C389
ENO3 Beta-enolase
7690


P19838_C261
NFKB1 Nuclear factor NF-kappa-B
7691



p105 subunit


Q96IJ6_C389
GMPPA Mannose-1-phosphate
7692



guanyltransferase alpha


P78527_C3187
PRKDC DNA-dependent protein
7693



kinase catalytic subunit


P04083_C270
ANXA1 Annexin A1
7694


Q86WV6_C309
TMEM173 Transmembrane protein
7695



173


P31949_C13
S100A11 Protein S100-A11
7696


Q16181_C280
SEPT7 Septin-7
7697


P53621_C1185
COPA Coatomer subunit alpha
7698


O75179_C210
ANKRD17 Ankyrin repeat domain-
7699



containing protein 17


P62333_C193
PSMC6 26S protease regulatory
7700



subunit 10B


Q9Y5P6_C245
GMPPB Mannose-1-phosphate
7701



guanyltransferase beta


P31948_C461
STIP1 Stress-induced-phosphoprotein 1
7702


Q96P48_C900
ARAP1 Arf-GAP with Rho-GAP
7703



domain, ANK repeat and PH domain 1


Q52LJ0_C216
FAM98B Protein FAM98B
7704


P46779_C13
RPL28 60S ribosomal protein L28
7705


Q8N5W9_C81
FAM101B Protein FAM101B
7706


P50914_C54
RPL14 60S ribosomal protein L14
7707


P00338_C293
LDHA L-lactate dehydrogenase A
7708



chain


P62993_C32
GRB2 Growth factor receptor-bound
7709



protein 2


P85037_C439
FOXK1 Forkhead box protein K1
7710


Q14103_C126
HNRNPD Heterogeneous nuclear
7711



ribonucleoprotein D0


Q9NVA2_C41
SEPT11 Septin-11
7712


P43403_C346
ZAP70 Tyrosine-protein kinase ZAP-
7713



70


Q562E7_C130
WDR81 WD repeat-containing protein
7714



81


O60610_C796
DIAPH1 Protein diaphanous homolog 1
7715


P08133_C552
ANXA6 Annexin A6
7716


Q13418_C346
ILK Integrin-linked protein kinase
7717


P49915_C523
GMPS GMP synthase
7718


Q15459_C244
SF3A1 Splicing factor 3A subunit 1
7719


Q06124_C259
PTPN11 Tyrosine-protein phosphatase
7720



non-receptor type 11


Q02338_C288
BDH1 D-beta-hydroxybutyrate
7721



dehydrogenase, mitochondrial


P46060_C338
RANGAP1 Ran GTPase-activating
7722



protein 1


Q14204_C4216
DYNC1H1 Cytoplasmic dynein 1
7723



heavy chain 1


P40926_C285
MDH2 Malate dehydrogenase,
7724



mitochondrial


Q9NX63_C112
CHCHD3 Coiled-coil-helix-coiled-coil-
7725



helix domain-containing protein 3


P62280_C116
RPS11 40S ribosomal protein S11
7726


Q9BZV1_C125
UBXN6 UBX domain-containing
7727



protein 6


O00299_C178
CLIC1 Chloride intracellular channel
7728



protein 1


O75592_C1131
MYCBP2 Probable E3 ubiquitin-
7729



protein ligase MYCBP2


P61601_C185
NCALD Neurocalcin-delta
7730


P15498_C794
VAV1 Proto-oncogene vav
7731


P12004_C81
PCNA Proliferating cell nuclear antigen
7732


P60981_C23
DSTN Destrin
7733


P14618_C474
PKM Pyruvate kinase isozymes M1/M2
7734


Q9Y3F4_C340
STRAP Serine-threonine kinase
7735



receptor-associated protein


O75694_C704
NUP155 Nuclear pore complex protein
7736



Nup155


Q92888_C594
ARHGEF1 Rho guanine nucleotide
7737



exchange factor 1


O00264_C129
PGRMC1 Membrane-associated
7738



progesterone receptor component


O15173_C159
PGRMC2 Membrane-associated
7739



progesterone receptor component


Q15691_C228
MAPRE1 Microtubule-associated
7740



protein RP/EB family member


Q13325_C137
IFIT5 Interferon-induced protein with
7741



tetratricopeptide


Q9Y678_C296
COPG1 Coatomer subunit gamma-1
7742


Q5XKP0_C60
QIL1 Protein QIL1
7743


O43776_C438
NARS Asparagine--tRNA ligase,
7744



cytoplasmic


O75531_C85
BANF1 Barrier-to-autointegration
7745



factor


Q00577_C272
PURA Transcriptional activator protein
7746



Pur-alpha


P61758_C113
VBP1 Prefoldin subunit 3
7747


P62330_C155
ARF6 ADP-ribosylation factor 6
7748


P09110_C381
ACAA1 3-ketoacyl-CoA thiolase,
7749



peroxisomal


P60842_C134
EIF4A1 Eukaryotic initiation factor
7750



4A-I


Q8N1G4_C249
LRRC47 Leucine-rich repeat-
7751



containing protein 47


Q9Y5Z7_C673
HCFC2 Host cell factor 2
7752


P30485_C125
HLA-B HLA class I histocompatibility
7753



antigen, B-47 alpha


P51812_C579
RPS6KA3 Ribosomal protein S6 kinase
7754



alpha-3


Q15418_C575
RPS6KA1 Ribosomal protein S6 kinase
7755



alpha-1


Q9P2J5_C554
LARS Leucine--tRNA ligase,
7756



cytoplasmic


P00558_C108
PGK1 Phosphoglycerate kinase 1
7757


O14966_C120
RAB7L1 Ras-related protein Rab-7L1
7758


P13639_C591
EEF2 Elongation factor 2
7759


P07195_C36
LDHB L-lactate dehydrogenase B
7760



chain


Q96EY7_C642
PTCD3 Pentatricopeptide repeat-
7761



containing protein 3, mitochondrial


Q13469_C355
NFATC2 Nuclear factor of activated T-
7762



cells, cytoplasmic 2


Q96JH7_C219
VCPIP1 Deubiquitinating protein
7763



VCIP135


Q92619_C324
HMHA1 Minor histocompatibility
7764



protein HA-1


O00148_C164
DDX39A ATP-dependent RNA
7765



helicase DDX39A


P16455_C150
MGMT Methylated-DNA--protein-
7766



cysteine methyltransferase


P40763_C259
STAT3 Signal transducer and activator
7767



of transcription 3


P07203_C202
GPX1 Glutathione peroxidase 1
7768


P08575_C787
PTPRC Receptor-type tyrosine-protein
7769



phosphatase C


Q9Y6E0_C394
STK24 Serine/threonine-protein kinase
7770



24


B5ME19_C444
EIF3CL Eukaryotic translation
7771



initiation factor 3 subunit


P33240_C150
CSTF2 Cleavage stimulation factor
7772



subunit 2


P52597_C267
HNRNPF Heterogeneous nuclear
7773



ribonucleoprotein F


Q9H019_C52
FAM54B Protein FAM54B
7774


Q9H479_C24
FN3K Fructosamine-3-kinase
7775


O75369_C660
FLNB Filamin-B
7776


P62241_C100
RPS8 40S ribosomal protein S8
7777


P30453_C188
HLA-A HLA class I histocompatibility
7778



antigen, A-34 alpha


P01892_C188
HLA-A HLA class I histocompatibility
7779



antigen, A-2 alpha


P01891_C188
HLA-A HLA class I histocompatibility
7780



antigen, A-68 alpha


P30479_C188
HLA-B HLA class I histocompatibility
7781



antigen, B-41 alpha


P30460_C188
HLA-B HLA class I histocompatibility
7782



antigen, B-8 alpha


P43250_C474
GRK6 G protein-coupled receptor
7783



kinase 6


Q96JB2_C65
COG3 Conserved oligomeric Golgi
7784



complex subunit 3


P22102_C646
GART Trifunctional purine
7785



biosynthetic protein adenosine


Q9BTC0_C1079
DIDO1 Death-inducer obliterator 1
7786


Q5SY16_C648
NOL9 Polynucleotide 5-hydroxyl-
7787



kinase NOL9


O75367_C297
H2AFY Core histone macro-H2A.1
7788


P10314_C188
HLA-A HLA class I histocompatibility
7789



antigen, A-32 alpha


P30512_C188
HLA-A HLA class I histocompatibility
7790



antigen, A-29 alpha


P30510_C188
HLA-C HLA class I histocompatibility
7791



antigen, Cw-14 alpha


Q9TNN7_C188
HLA-C HLA class I histocompatibility
7792



antigen, Cw-5 alpha


P30459_C188
HLA-A HLA class I histocompatibility
7793



antigen, A-74 alpha


Q29963_C188
HLA-C HLA class I histocompatibility
7794



antigen, Cw-6 alpha


Q29960_C188
HLA-C HLA class I histocompatibility
7795



antigen, Cw-16 alpha


Q07000_C188
HLA-C HLA class I histocompatibility
7796



antigen, Cw-15 alpha


P16189_C188
HLA-A HLA class I histocompatibility
7797



antigen, A-31 alpha


Q29865_C188
HLA-C HLA class I histocompatibility
7798



antigen, Cw-18 alpha


P30504_C188
HLA-C HLA class I histocompatibility
7799



antigen, Cw-4 alpha


O60343_C1277
TBC1D4 TBC1 domain family member
7800



4


Q14152_C478
EIF3A Eukaryotic translation initiation
7801



factor 3 subunit


E9PMF8_C721
PTPRC Receptor-type tyrosine-protein
7802



phosphatase C


Q01831_C60
XPC DNA repair protein
7803



complementing XP-C cells


P55265_C773
ADAR Double-stranded RNA-specific
7804



adenosine deaminase


P30153_C377
PPP2R1A Serine/threonine-protein
7805



phosphatase 2A 65 kDa regulatory



subunit A alpha isoform


A6NE09_C148
RPSAP58 Protein RPSAP58
7806


Q9TNN7_C125
HLA-C HLA class I histocompatibility
7807



antigen, Cw-5 alpha


Q95604_C125
HLA-C HLA class I histocompatibility
7808



antigen, Cw-17 alpha


Q29963_C125
HLA-C HLA class I histocompatibility
7809



antigen, Cw-6 alpha


Q29960_C125
HLA-C HLA class I histocompatibility
7810



antigen, Cw-16 alpha


Q07000_C125
HLA-C HLA class I histocompatibility
7811



antigen, Cw-15 alpha


Q9ULA0_C144
DNPEP Aspartyl aminopeptidase
7812


P53396_C20
ACLY ATP-citrate synthase
7813


P35251_C607
RFC1 Replication factor C subunit 1
7814


Q8IZ69_C463
TRMT2A tRNA (uracil-5-)-
7815



methyltransferase homolog A


O00567_C52
NOP56 Nucleolar protein 56
7816


Q5JSL3_C160
DOCK11 Dedicator of cytokinesis
7817



protein 11


P21333_C649
FLNA Filamin-A
7818


P21291_C122
CSRP1 Cysteine and glycine-rich
7819



protein 1


P22314_C278
UBA1 Ubiquitin-like modifier-
7820



activating enzyme 1


Q9P289_C410
MST4 Serine/threonine-protein kinase
7821



MST4


P46782_C66
RPS5 40S ribosomal protein S5
7822


Q92616_C1235
GCN1L1 Translational activator GCN1
7823


P27707_C45
DCK Deoxycytidine kinase
7824


Q8NF91_C6415
SYNE1 Nesprin-1
7825


Q92538_C685
GBF1 Golgi-specific brefeldin A-
7826



resistance guanine nucleotide exchange



factor 1


P13639_C290
EEF2 Elongation factor 2
7827


Q15120_C41
PDK3
7828


O43765_C153
SGTA Small glutamine-rich
7829



tetratricopeptide repeat-containing



alpha


P63244_C182
GNB2L1 Guanine nucleotide-binding
7830



protein subunit beta-2-like 1, N-



terminally processed


P61978_C145
HNRNPK Heterogeneous nuclear
7831



ribonucleoprotein K


Q9Y3D0_C93
FAM96B Mitotic spindle-associated
7832



MMXD complex subunit MI


H3BQZ7_C405
Uncharacterized protein
7833


Q1KMD3_C405
HNRNPUL2 Heterogeneous nuclear
7834



ribonucleoprotein U-like protein 2


Q92888_C815
ARHGEF1 Rho guanine nucleotide
7835



exchange factor 1


P30050_C17
RPL12 60S ribosomal protein L12
7836


P27348_C134
YWHAQ 14-3-3 protein theta
7837


Q9UPW5_C1164
AGTPBP1 Cytosolic carboxypeptidase
7838



1


Q13185_C177
CBX3 Chromobox protein homolog 3
7839


P50914_C42
RPL14 60S ribosomal protein L14
7840


P60709_C217
ACTB Actin, cytoplasmic 1
7841


Q6S8J3_C917
POTEE POTE ankyrin domain family
7842



member E


Q52LJ0_C63
FAM98B Protein FAM98B
7843


Q8TAQ2_C495
SMARCC2 SWI/SNF complex subunit
7844



SMARCC2


P04083_C324
ANXA1 Annexin A1
7845


Q86VP6_C413
CAND1 Cullin-associated NEDD8-
7846



dissociated protein 1


P40925_C137
MDH1 Malate dehydrogenase,
7847



cytoplasmic


P23528_C80
CFL1 Cofilin-1
7848


Q14C86_C568
GAPVD1 GTPase-activating protein
7849



and VPS9 domain-containing protein 1


P62241_C182
RPS8 40S ribosomal protein S8
7850


Q86WR0_C83
CCDC25 Coiled-coil domain-
7851



containing protein 25


P00558_C50
PGK1 Phosphoglycerate kinase 1
7852


O00743_C192
PPP6C Serine/threonine-protein
7853



phosphatase 6 catalytic subunit


O75934_C106
BCAS2 Pre-mRNA-splicing factor
7854



SPF27


Q92616_C1692
GCN1L1 Translational activator GCN1
7855


Q63HN8_C1614
RNF213 E3 ubiquitin-protein ligase
7856



RNF213


P17655_C405
CAPN2 Calpain-2 catalytic subunit
7857


P43487_C132
RANBP1 Ran-specific GTPase-
7858



activating protein


Q9BVP2_C251
GNL3 Guanine nucleotide-binding
7859



protein-like 3


O75995_C152
SASH3 SAM and SH3 domain-
7860



containing protein 3


Q7Z6Z7_C4341
HUWE1 E3 ubiquitin-protein ligase
7861



HUWE1


P21333_C2107
FLNA Filamin-A
7862


Q9UQ90_C353
SPG7 Paraplegin
7863


H3BN98_C196
Uncharacterized protein
7864


P62244_C30
RPS15A 40S ribosomal protein S15a
7865


Q9UPN7_C455
PPP6R1 Serine/threonine-protein
7866



phosphatase 6 regulatory


P26641_C266
EEF1G Elongation factor 1-gamma
7867


Q96F07_C346
CYFIP2 Cytoplasmic FMR1-
7868



interacting protein 2


Q16555_C504
DPYSL2 Dihydropyrimidinase-related
7869



protein 2


Q9H3U1_C426
UNC45A Protein unc-45 homolog A
7870


Q9UBT2_C30
UBA2 SUMO-activating enzyme
7871



subunit 2


O60333_C1661
KIF1B Kinesin-like protein KIF1B
7872


P35579_C1379
MYH9 Myosin-9
7873


P17844_C170
DDX5 Probable ATP-dependent RNA
7874



helicase DDX5


Q92841_C247
DDX17 Probable ATP-dependent RNA
7875



helicase DDX17


I3L3Q1_C657
Uncharacterized protein
7876


Q6ZSZ5_C699
ARHGEF18 Rho guanine nucleotide
7877



exchange factor 18


Q15233_C145
NONO Non-POU domain-containing
7878



octamer-binding protein


Q9Y490_C1202
TLN1 Talin-1
7879


Q9H0C8_C301
ILKAP Integrin-linked kinase-
7880



associated serine/threonine


Q63HN8_C4111
RNF213 E3 ubiquitin-protein ligase
7881



RNF213


P54886_C612
ALDH18A1 Delta-1-pyrroline-5-
7882



carboxylate synthase


Q9Y613_C502
FHOD1 FH1/FH2 domain-containing
7883



protein 1


Q86TI0_C604
TBC1D1 TBC1 domain family member
7884



1


O60234_C96
GMFG Glia maturation factor gamma
7885


P60983_C96
GMFB Glia maturation factor beta
7886


Q9UIS9_C486
MBD1 Methyl-CpG-binding domain
7887



protein 1


Q9HB19_C332
PLEKHA2 Pleckstrin homology
7888



domain-containing family A member 2


O60234_C87
GMFG Glia maturation factor gamma
7889


P60983_C87
GMFB Glia maturation factor beta
7890


Q6FI81_C288
CIAPIN1 Anamorsin
7891


Q5T4S7_C1230
UBR4 E3 ubiquitin-protein ligase
7892



UBR4


Q01826_C173
SATB1 DNA-binding protein SATB1
7893


Q9Y490_C1199
TLN1 Talin-1
7894


Q16656_C229
NRF1 Nuclear respiratory factor 1
7895


P60866_C36
RPS20 40S ribosomal protein S20
7896


Q9H361_C132
PABPC3 Polyadenylate-binding protein
7897



3


Q13310_C132
PABPC4 Polyadenylate-binding protein
7898



4


P11940_C132
PABPC1 Polyadenylate-binding protein
7899



1


P31943_C267
HNRNPH1 Heterogeneous nuclear
7900



ribonucleoprotein H


O43390_C99
HNRNPR Heterogeneous nuclear
7901



ribonucleoprotein R


O60506_C96
SYNCRIP Heterogeneous nuclear
7902



ribonucleoprotein Q


P36578_C208
RPL4 60S ribosomal protein L4
7903


O75170_C247
PPP6R2 Serine/threonine-protein
7904



phosphatase 6 regulatory


Q14644_C58
RASA3 Ras GTPase-activating protein
7905



3


Q01433_C230
AMPD2 AMP deaminase 2
7906


P55795_C267
HNRNPH2 Heterogeneous nuclear
7907



ribonucleoprotein H2


P63104_C94
YWHAZ 14-3-3 protein zeta/delta
7908


Q9BXK1_C233
KLF16 Krueppel-like factor 16
7909


Q9UKV8_C188
EIF2C2 Protein argonaute-2
7910


Q9NVM9_C349
Asun Protein asunder homolog
7911


P24928_C981
POLR2A DNA-directed RNA
7912



polymerase II subunit RPB1


Q15283_C314
RASA2 Ras GTPase-activating protein
7913



2


P61224_C141
RAP1B Ras-related protein Rap-1b
7914


P13804_C155
ETFA Electron transfer flavoprotein
7915



subunit alpha, mitochondrial


Q14353_C91
GAMT Guanidinoacetate N-
7916



methyltransferase


Q92616_C1595
GCN1L1 Translational activator GCN1
7917


O75995_C351
SASH3 SAM and SH3 domain-
7918



containing protein 3


Q9H270_C890
VPS11 Vacuolar protein sorting-
7919



associated protein 11 homolog


P31948_C26
STIP1 Stress-induced-phosphoprotein 1
7920


Q13303_C248
KCNAB2 Voltage-gated potassium
7921



channel subunit beta-2


Q86X76_C165
NIT1 Nitrilase homolog 1
7922


P31146_C285
CORO1A Coronin-1A
7923


Q02750_C277
MAP2K1 Dual specificity mitogen-
7924



activated protein kinase


O95758_C68
PTBP3 Polypyrimidine tract-binding
7925



protein 3


P53621_C380
COPA Coatomer subunit alpha
7926


Q9BUJ2_C487
HNRNPUL1 Heterogeneous nuclear
7927



ribonucleoprotein U-like protein


Q92619_C469
HMHA1 Minor histocompatibility
7928



protein HA-1


Q9Y228_C380
TRAF3IP3 TRAF3-interacting JNK-
7929



activating modulator


Q9BW61_C25
DDA1 DET1- and DDB1-associated
7930



protein 1


P21333_C1018
FLNA Filamin-A
7931


O75427_C105
LRCH4 Leucine-rich repeat and
7932



calponin homology domain-containing



protein 4


P22314_C481
UBA1 Ubiquitin-like modifier-
7933



activating enzyme 1


Q8N7H5_C218
PAF1 RNA polymerase II-associated
7934



factor 1 homolog


Q16644_C203
MAPKAPK3 MAP kinase-activated
7935



protein kinase 3


Q6PD62_C196
CTR9 RNA polymerase-associated
7936



protein CTR9 homolog


P23919_C163
DTYMK Thymidylate kinase
7937


Q9UKG1_C462
APPL1 DCC-interacting protein 13-
7938



alpha


Q13155_C306
AIMP2 Aminoacyl tRNA synthase
7939



complex-interacting multif


Q99439_C215
CNN2 Calponin-2
7940


Q99832_C450
CCT7 T-complex protein 1 subunit eta
7941


Q8IXI2_C175
RHOT1 Mitochondrial Rho GTPase 1
7942


Q9Y4W2_C474
LAS1L Ribosomal biogenesis protein
7943



LAS1L


P13716_C223
ALAD Delta-aminolevulinic acid
7944



dehydratase


Q8IWX8_C168
CHERP Calcium homeostasis
7945



endoplasmic reticulum protein


P08575_C1167
PTPRC Receptor-type tyrosine-protein
7946



phosphatase C


E9PPU0_C406
EPPK1 Epiplakin
7947


P15170_C327
GSPT1 Eukaryotic peptide chain
7948



release factor GTP-binding subunit



ERF3A


Q9NZN3_C138
EHD3 EH domain-containing protein 3
7949


Q8WUH2_C826
TGFBRAP1 Transforming growth
7950



factor-beta receptor-associate protein 1


Q9BZZ5_C234
API5 Apoptosis inhibitor 5
7951


P53992_C910
SEC24C Protein transport protein
7952



Sec24C


O15027_C1619
SEC16A Protein transport protein
7953



Sec16A


O43791_C361
SPOP Speckle-type POZ protein
7954


O95202_C552
LETM1 LETM1 and EF-hand domain-
7955



containing protein 1, mitochondrial


Q9NZ09_C161
UBAP1 Ubiquitin-associated protein 1
7956


P45880_C103
VDAC2 Voltage-dependent anion-
7957



selective channel protein


Q8IWB7_C401
WDFY1 WD repeat and FYVE
7958



domain-containing protein 1


O60216_C585
RAD21 Double-strand-break repair
7959



protein rad21 homolog


O00567_C142
NOP56 Nucleolar protein 56
7960


P55265_C649
ADAR Double-stranded RNA-specific
7961



adenosine deaminase


Q8WYP5_C521
AHCTF1 Protein ELYS
7962


Q6PKG0_C502
LARP1 La-related protein 1
7963


Q6PJW8_C192
CNST Consortin
7964


Q5VSL9_C418
FAM40A Protein FAM40A
7965


Q92835_C385
INPP5D Phosphatidylinositol 3,4,5-
7966



trisphosphate 5-phosphatase 1


Q00610_C736
CLTC Clathrin heavy chain 1
7967


Q14019_C10
COTL1 Coactosin-like protein
7968


Q9UEW8_C450
STK39 STE20/SPS1-related proline-
7969



alanine-rich protein kinase


P22626_C50
HNRNPA2B1 Heterogeneous nuclear
7970



ribonucleoproteins A2/B1


P55795_C22
HNRNPH2 Heterogeneous nuclear
7971



ribonucleoprotein H2


Q8IXW5_C105
RPAP2 Putative RNA polymerase II
7972



subunit B1 CTD phosphatase RPAP2


Q92841_C584
DDX17 Probable ATP-dependent RNA
7973



helicase DDX17


P50552_C334
VASP Vasodilator-stimulated
7974



phosphoprotein


P29728_C523
OAS2 2-5-oligoadenylate synthase 2
7975


Q9BUJ2_C391
HNRNPUL1 Heterogeneous nuclear
7976



ribonucleoprotein U-like protein


Q5VWQ0_C282
RSBN1 Round spermatid basic protein
7977



1


O75369_C2556
FLNB Filamin-B
7978


P04075_C178
ALDOA Fructose-bisphosphate
7979



aldolase A


Q9UID3_C81
VPS51 Vacuolar protein sorting-
7980



associated protein 51 homolog


Q9ULL5_C173
PRR12 Proline-rich protein 12
7981


P14618_C423
PKM Pyruvate kinase isozymes M1/M2
7982


O15117_C778
FYB FYN-binding protein
7983


Q02880_C426
TOP2B DNA topoisomerase 2-beta
7984


P14618_C424
PKM Pyruvate kinase isozymes M1/M2
7985


O14976_C913
GAK Cyclin-G-associated kinase
7986


Q14980_C1907
NUMA1 Nuclear mitotic apparatus
7987



protein 1


Q86WI3_C1190
NLRC5 Protein NLRC5
7988


Q6IS14_C129
EIF5AL1 Eukaryotic translation
7989



initiation factor 5A-1-like


Q9Y2X3_C106
NOP58 Nucleolar protein 58
7990


Q9NRG7_C78
SDR39U1 Epimerase family protein
7991



SDR39U1


Q14761_C134
PTPRCAP Protein tyrosine
7992



phosphatase receptor type C-associated



protein


P30479_C349
HLA-B HLA class I histocompatibility
7993



antigen, B-41 alpha


P30460_C349
HLA-B HLA class I histocompatibility
7994



antigen, B-8 alpha


Q6KC79_C2151
NIPBL Nipped-B-like protein
7995


P26038_C284
MSN Moesin
7996


Q9UL15_C118
BAG5 BAG family molecular
7997



chaperone regulator 5


Q15022_C325
SUZ12 Polycomb protein SUZ12
7998


Q8NBZ0_C179
INO80E INO80 complex subunit E
7999


P42226_C355
STAT6 Signal transducer and activator
8000



of transcription 6


P37802_C63
TAGLN2 Transgelin-2
8001


O60313_C786
OPA1 Dynamin-like 120 kDa protein,
8002



mitochondrial


Q8TB24_C881
RIN3 Ras and Rab interactor 3
8003


P42226_C356
STAT6 Signal transducer and activator
8004



of transcription 6


P13639_C693
EEF2 Elongation factor 2
8005


P13010_C493
XRCC5 X-ray repair cross-
8006



complementing protein 5


Q9NX46_C132
ADPRHL2 Poly(ADP-ribose)
8007



glycohydrolase ARH3


Q5RL73_C199
RBM48 RNA-binding protein 48
8008


P09001_C338
MRPL3 39S ribosomal protein L3,
8009



mitochondrial


Q14204_C3089
DYNC1H1 Cytoplasmic dynein 1
8010



heavy chain 1


Q15437_C767
SEC23B Protein transport protein
8011



Sec23B


P30040_C157
ERP29 Endoplasmic reticulum resident
8012



protein 29


Q9UQ35_C956
SRRM2 Serine/arginine repetitive
8013



matrix protein 2


Q5RL73_C204
RBM48 RNA-binding protein 48
8014


Q12996_C646
CSTF3 Cleavage stimulation factor
8015



subunit 3


P15170_C276
GSPT1 Eukaryotic peptide chain
8016



release factor GTP-binding subunit



ERF3A


Q9BY32_C146
ITPA Inosine triphosphate
8017



pyrophosphatase


Q9Y3Z3_C80
SAMHD1 SAM domain and HD
8018



domain-containing protein 1


Q99590_C566
SCAF11 Protein SCAF11
8019


Q9BSQ5_C170
CCM2 Malcavernin
8020


P07737_C128
PFN1 Profilin-1
8021


P45974_C195
USP5 Ubiquitin carboxyl-terminal
8022



hydrolase 5


Q9H2U2_C44
PPA2 Inorganic pyrophosphatase 2,
8023



mitochondrial


Q92530_C185
PSMF1 Proteasome inhibitor PI31
8024



subunit


P26599_C23
PTBP1 Polypyrimidine tract-binding
8025



protein 1


P57075_C435
UBASH3A Ubiquitin-associated and
8026



SH3 domain-containing protein A


P25208_C89
NFYB Nuclear transcription factor Y
8027



subunit beta


Q8N6S5_C48
ARL6IP6 ADP-ribosylation factor-like
8028



protein 6-interacting protein 6


Q96AP0_C406
ACD Adrenocortical dysplasia protein
8029



homolog


P25208_C85
NFYB Nuclear transcription factor Y
8030



subunit beta


O14745_C206
SLC9A3R1 Na(+)/H(+) exchange
8031



regulatory cofactor NHE-RF1


Q9H6S0_C363
YTHDC2 Probable ATP-dependent
8032



RNA helicase YTHDC2


Q9BY32_C154
ITPA Inosine triphosphate
8033



pyrophosphatase


Q9UQ13_C306
SHOC2 Leucine-rich repeat protein
8034



SHOC-2


P30876_C177
POLR2B DNA-directed RNA
8035



polymerase II subunit RPB2


Q8TB24_C484
RIN3 Ras and Rab interactor 3
8036


P37802_C38
TAGLN2 Transgelin-2
8037


P60174_C255
TPI1 Triosephosphate isomerase
8038


Q99832_C511
CCT7 T-complex protein 1 subunit eta
8039


O75592_C3152
MYCBP2 Probable E3 ubiquitin-
8040



protein ligase MYCBP2


Q9BSH5_C243
HDHD3 Haloacid dehalogenase-like
8041



hydrolase domain-containing 3


Q13573_C250
SNW1 SNW domain-containing
8042



protein 1


P46777_C100
RPL5 60S ribosomal protein L5
8043


O95571_C170
ETHE1 Protein ETHE1, mitochondrial
8044


Q92556_C726
ELMO1 Engulfment and cell motility
8045



protein 1


P84074_C185
HPCA Neuron-specific calcium-
8046



binding protein hippocalcin


P37235_C185
HPCAL1 Hippocalcin-like
8047



protein 1


Q9BSJ8_C370
ESYT1 Extended
8048



synaptotagmin-1


P51610_C227
HCFC1 Host cell factor 1
8049


P49753_C401
ACOT2 Acyl-coenzyme A
8050



thioesterase 2, mitochondrial


J3QR44_C430
CDK11B Cyclin-dependent
8051



kinase 11B


P21127_C440
CDK11B Cyclin-dependent
8052



kinase 11B


O43149_C69
ZZEF1 Zinc finger ZZ-type
8053



and EF-hand domain-



containing


Q9NZB2_C531
FAM120A Constitutive
8054



coactivator of PPAR-gamma-



like protein 1


Q6PJT7_C261
ZC3H14 Zinc finger CCCH
8055



domain-containing protein 14


Q9Y613_C31
FHOD1 FH1/FH2 domain-
8056



containing protein 1


Q9Y4F9_C596
FAM65B Protein FAM65B
8057


Q93084_C614
ATP2A3
8058



Sarcoplasmic/endoplasmic



reticulum calcium ATPase


P78527_C25
PRKDC DNA-dependent
8059



protein kinase catalytic subunit


Q15027_C501
ACAP1 Arf-GAP with coiled-
8060



coil, ANK repeat and PH



domain 1


Q9H2M9_C1336
RAB3GAP2 Rab3 GTPase-
8061



activating protein non-catalytic



subunit


P62857_C27
RPS28 40S ribosomal protein
8062



S28


P60981_C163
DSTN Destrin
8063


Q96SK2_C158
TMEM209 Transmembrane
8064



protein 209


P15153_C178
RAC2 Ras-related C3
8065



botulinum toxin substrate 2


P37802_C124
TAGLN2 Transgelin-2
8066


Q63HN8_C3554
RNF213 E3 ubiquitin-protein
8067



ligase RNF213


O94915_C888
FRYL Protein furry homolog-
8068



like


Q9UPR0_C90
PLCL2 Inactive phospholipase
8069



C-like protein 2


Q96ME7_C324
ZNF512 Zinc finger protein
8070



512


Q8IZ73_C431
RPUSD2 RNA
8071



pseudouridylate synthase



domain-containing protein


Q5SNT2_C498
TMEM201 Transmembrane
8072



protein 201


Q14980_C1937
NUMA1 Nuclear mitotic
8073



apparatus protein 1


Q9BSD7_C184
NTPCR Cancer-related
8074



nucleoside-triphosphatase


P56192_C441
MARS Methionine--tRNA
8075



ligase, cytoplasmic


Q9BWW4_C80
SSBP3 Single-stranded DNA-
8076



binding protein 3


P62834_C139
RAP1A Ras-related protein
8077



Rap-1A


P49448_C172
GLUD2 Glutamate
8078



dehydrogenase 2,



mitochondrial


P00367_C172
GLUD1 Glutamate
8079



dehydrogenase 1,



mitochondrial


P23396_C134
RPS3 40S ribosomal protein
8080



S3


O75947_C101
ATP5H ATP synthase subunit
8081



d, mitochondrial


Q9HC38_C171
GLOD4 Glyoxalase domain-
8082



containing protein 4


O00233_C59
PSMD9 26S proteasome non-
8083



ATPase regulatory subunit 9


P14866_C472
HNRNPL Heterogeneous
8084



nuclear ribonucleoprotein L


Q04206_C105
RELA Transcription factor
8085



p65


Q96FW1_C23
OTUB1 Ubiquitin thioesterase
8086



OTUB1


Q9UI30_C33
TRMT112 tRNA
8087



methyltransferase 112



homolog


O43815_C316
STRN Striatin
8088


P08047_C755
SP1 Transcription factor Sp1
8089


P60174_C104
TPI1 Triosephosphate
8090



isomerase


O75362_C286
ZNF217 Zinc finger protein
8091



217


O60496_C36
DOK2 Docking protein 2
8092


P49792_C2791
RANBP2 E3 SUMO-protein
8093



ligase RanBP2


Q13428_C38
TCOF1 Treacle protein
8094


Q8TD47_C41
RPS4Y2 40S ribosomal
8095



protein S4, Y isoform 2


P22090_C41
RPS4Y1 40S ribosomal
8096



protein S4, Y isoform 1


Q8NDH3_C504
NPEPL1 Probable
8097



aminopeptidase NPEPL1


Q96P11_C362
NSUN5 Putative
8098



methyltransferase NSUN5


Q8N3X1_C877
FNBP4 Formin-binding
8099



protein 4


Q92685_C21
ALG3 Dol-P-
8100



Man:Man(5)GlcNAc(2)-PP-



Dol alpha-1,3-



mannosyltransferase


Q00013_C242
MPP1 55 kDa erythrocyte
8101



membrane protein


Q9BTX1_C468
TMEM48 Nucleoporin NDC1
8102


Q96RU3_C609
FNBP1 Formin-binding
8103



protein 1


P31749_C310
AKT1 RAC-alpha
8104



serine/threonine-protein kinase


Q9Y243_C307
AKT3 RAC-gamma
8105



serine/threonine-protein kinase


P31751_C311
AKT2 RAC-beta
8106



serine/threonine-protein kinase


O95248_C1374
SBF1 Myotubularin-related
8107



protein 5


O94953_C694
KDM4B Lysine-specific
8108



demethylase 4B


O95295_C66
SNAPIN SNARE-associated
8109



protein Snapin


Q9Y4W2_C690
LAS1L Ribosomal biogenesis
8110



protein LAS1L


P29375_C838
KDM5A Lysine-specific
8111



demethylase 5A


P52948_C1068
NUP98 Nuclear pore complex
8112



protein Nup98-Nup96


Q9Y5Y2_C269
NUBP2 Cytosolic Fe—S cluster
8113



assembly factor NUBP2


P12814_C370
ACTN1 Alpha-actinin-1
8114


O75131_C506
CPNE3 Copine-3
8115


Q7Z2W4_C38
ZC3HAV1 Zinc finger CCCH-
8116



type antiviral protein 1


P51610_C1886
HCFC1 Host cell factor 1
8117


P51610_C1895
HCFC1 Host cell factor 1
8118


P40939_C322
HADHA Trifunctional enzyme
8119



subunit alpha, mitochondrial


Q63HN8_C3261
RNF213 E3 ubiquitin-protein
8120



ligase RNF213


I3L3Q1_C264
Uncharacterized protein
8121


Q6ZSZ5_C306
ARHGEF18 Rho guanine
8122



nucleotide exchange factor 18


Q9BRJ7_C88
NUDT16L1 Protein
8123



syndesmos


P52701_C615
MSH6 DNA mismatch repair
8124



protein Msh6


Q9Y4K1_C976
AIM1 Absent in melanoma 1
8125



protein


Q15631_C225
TSN Translin
8126


Q9H9L4_C117
KANSL2 KAT8 regulatory
8127



NSL complex subunit 2


Q66K74_C435
MAP1S Microtubule-
8128



associated protein 1S


Q66K74_C440
MAP1S Microtubule-
8129



associated protein 1S


O75319_C325
DUSP11 RNA/RNP complex-
8130



1-interacting phosphatase


Q02543_C16
RPL18A 60S ribosomal
8131



protein L18a


Q96HA1_C307
POM121 Nuclear envelope
8132



pore membrane protein POM



121


Q6PJE2_C42
POMZP3 POM121 and ZP3
8133



fusion protein


A8CG34_C284
POM121C Nuclear envelope
8134



pore membrane protein POM



121C


O14523_C359
C2CD2L C2 domain-
8135



containing protein 2-like


Q99986_C50
VRK1 Serine/threonine-
8136



protein kinase VRK1


P62995_C118
TRA2B Transformer-2 protein
8137



homolog beta


P62995_C119
TRA2B Transformer-2 protein
8138



homolog beta


Q15050_C52
RRS1 Ribosome biogenesis
8139



regulatory protein homolog


P08575_C608
PTPRC Receptor-type
8140



tyrosine-protein phosphatase C


O43704_C22
SULT1B1 Sulfotransferase
8141



family cytosolic 1B member 1


P46060_C573
RANGAP1 Ran GTPase-
8142



activating protein 1


E9PMF8_C542
PTPRC Receptor-type
8143



tyrosine-protein phosphatase C


Q13469_C386
NFATC2 Nuclear factor of
8144



activated T-cells, cytoplasmic



2


A6NHR9_C1710
SMCHD1 Structural
8145



maintenance of chromosomes



flexible hinge domain



containing 1


O43159_C451
RRP8 Ribosomal RNA-
8146



processing protein 8


Q99439_C274
CNN2 Calponin-2
8147


Q99439_C290
CNN2 Calponin-2
8148


Q06330_C397
RBPJ Recombining binding
8149



protein suppressor of hairless


O43264_C568
ZW10
8150



Centromere/kinetochore



protein zw10 homolog


Q8N806_C35
UBR7 Putative E3 ubiquitin-
8151



protein ligase UBR7


Q9UGV2_C359
NDRG3 Protein NDRG3
8152


P08758_C316
ANXA5 Annexin A5
8153


Q92878_C1296
RAD50 DNA repair protein
8154



RAD50


B0V043_C112
VARS Valyl-tRNA synthetase
8155


O94903_C261
PROSC Proline synthase co-
8156



transcribed bacterial homolog


P53041_C11
PPP5C Serine/threonine-
8157



protein phosphatase 5


Q92608_C1655
DOCK2 Dedicator of
8158



cytokinesis protein 2


P35236_C62
PTPN7 Tyrosine-protein
8159



phosphatase non-receptor type



7


Q86YV0_C896
RASAL3 RAS protein
8160



activator like-3


Q6P1X6_C98
C8orf82 UPF0598 protein
8161



C8orf82


Q8TDN6_C52
BRIX1 Ribosome biogenesis
8162



protein BRX1 homolog


Q15424_C225
SAFB Scaffold attachment
8163



factor B1


Q14151_C224
SAFB2 Scaffold attachment
8164



factor B2


Q8WXH0_C6161
SYNE2 Nesprin-2
8165


P45880_C13
VDAC2 Voltage-dependent
8166



anion-selective channel protein


Q92575_C144
UBXN4 UBX domain-
8167



containing protein 4


P07741_C83
APRT Adenine
8168



phosphoribosyltransferase


Q9BWH6_C1039
RPAP1 RNA polymerase II-
8169



associated protein 1


Q96EP0_C551
RNF31 E3 ubiquitin-protein
8170



ligase RNF31


Q9BYG3_C237
MKI67IP MKI67 FHA
8171



domain-interacting nucleolar



phosphoprotein


P17655_C39
CAPN2 Calpain-2 catalytic
8172



subunit


Q12789_C42
GTF3C1 General transcription
8173



factor 3C polypeptide 1


O00410_C1078
IPO5 Importin-5
8174


Q15796_C70
SMAD2 Mothers against
8175



decapentaplegic homolog 2


Q9H7D7_C656
WDR26 WD repeat-containing
8176



protein 26


O94804_C947
STK10 Serine/threonine-
8177



protein kinase 10


A6NHR9_C59
SMCHD1 Structural
8178



maintenance of chromosomes



flexible hinge domain



containing 1


Q13501_C26
SQSTM1 Sequestosome-1
8179


Q13501_C27
SQSTM1 Sequestosome-1
8180


P04899_C352
GNAI2 Guanine nucleotide-
8181



binding protein G(i) subunit



alpha-2


P40222_C523
TXLNA Alpha-taxilin
8182


Q6UUV9_C131
CRTC1 CREB-regulated
8183



transcription coactivator 1


O75643_C428
SNRNP200 U5 small nuclear
8184



ribonucleoprotein 200 kDa



helicas


P29590_C338
PML Protein PML
8185


Q32MZ4_C14
LRRMP1 Leucine-rich repeat
8186



flightless-interacting protein


P07814_C1487
EPRS Bifunctional
8187



glutamate/proline--tRNA



ligase


Q08999_C368
RBL2 Retinoblastoma-like
8188



protein 2


Q6IA86_C475
ELP2 Elongator complex
8189



protein 2


A6NHR9_C61
SMCHD1 Structural
8190



maintenance of chromosomes



flexible hinge domain



containing 1


P35611_C525
ADD1 Alpha-adducin
8191


P52701_C88
MSH6 DNA mismatch repair
8192



protein Msh6


Q14137_C108
BOP1 Ribosome biogenesis
8193



protein BOP1


Q12802_C1232
AKAP13 A-kinase anchor
8194



protein 13


Q92800_C423
EZH1 Histone-lysine N-
8195



methyltransferase EZH1


Q8N9N8_C89
EIF1AD Probable RNA-
8196



binding protein EIF1AD


Q13813_C2233
SPTAN1 Spectrin alpha chain,
8197



non-erythrocytic 1


Q96EK4_C48
THAP11 THAP domain-
8198



containing protein 11


O95267_C713
RASGRP1 RAS guanyl-
8199



releasing protein 1


P62851_C59
RPS25 40S ribosomal protein
8200



S25


O60551_C104
NMT2 Glycylpeptide N-
8201



tetradecanoyltransferase 2


Q9Y228_C135
TRAF3IP3 TRAF3-interacting
8202



JNK-activating modulator


I3L1I5_C189
Uncharacterized protein
8203


P08047_C68
SP1 Transcription factor Sp1
8204


E7ETI0_C21
ARPC4-TTLL3 Protein
8205



ARPC4-TTLL3


P59998_C21
ARPC4 Actin-related protein
8206



2/3 complex subunit 4


Q7KZ85_C336
SUPT6H Transcription
8207



elongation factor SPT6


Q9HB58_C461
SP110 Sp110 nuclear body
8208



protein


B0I1T2_C793
MYO1G Unconventional
8209



myosin-Ig


Q99497_C106
PARK7 Protein DJ-1
8210


Q9HB19_C191
PLEKHA2 Pleckstrin
8211



homology domain-containing



family A member 2


B0I1T2_C788
MYO1G Unconventional
8212



myosin-Ig


Q9NWY4_C17
C4orf27 UPF0609 protein
8213



C4orf27


Q9H4L4_C243
SENP3 Sentrin-specific
8214



protease 3


A0AVT1_C347
UBA6 Ubiquitin-like
8215



modifier-activating enzyme 6


P23497_C238
SP100 Nuclear autoantigen
8216



Sp-100


Q9NU22_C4041
MDN1 Midasin
8217


Q92835_C506
INPP5D Phosphatidylinositol
8218



3,4,5-trisphosphate 5-



phosphatase D


Q66GS9_C316
CEP135 Centrosomal protein
8219



of 135 kDa


P48739_C13
PITPNB Phosphatidylinositol
8220



transfer protein beta isoform


P35914_C323
HMGCL
8221



Hydroxymethylglutaryl-CoA



lyase, mitochondrial


Q5JSL3_C1190
DOCK11 Dedicator of
8222



cytokinesis protein 11


Q96JY6_C160
PDLIM2 PDZ and LIM
8223



domain protein 2


Q7Z5K2_C94
WAPAL Wings apart-like
8224



protein homolog


Q00653_C57
NFKB2 Nuclear factor NF-
8225



kappa-B p100 subunit


Q8TC07_C686
TBC1D15 TBC1 domain
8226



family member 15


Q8N1F7_C422
NUP93 Nuclear pore complex
8227



protein Nup93


P57678_C210
GEMIN4 Gem-associated
8228



protein 4


Q7Z5R6_C401
APBB1IP Amyloid beta A4
8229



precursor protein-binding



family B


Q9NX24_C18
NHP2 H/ACA
8230



ribonucleoprotein complex



subunit 2


P55265_C622
ADAR Double-stranded RNA-
8231



specific adenosine deaminase


Q8WVV9_C464
HNRPLL Heterogeneous
8232



nuclear ribonucleoprotein L-



like


Q99832_C364
CCT7 T-complex protein 1
8233



subunit eta


P63244_C286
GNB2L1 Guanine nucleotide-
8234



binding protein subunit beta-2-



like 1


Q13427_C310
PPIG Peptidyl-prolyl cis-trans
8235



isomerase G


P48147_C25
PREP Prolyl endopeptidase
8236


Q9UJZ1_C167
STOML2 Stomatin-like
8237



protein 2


O75369_C26
FLNB Filamin-B
8238


P21333_C53
FLNA Filamin-A
8239


Q92974_C335
ARHGEF2 Rho guanine
8240



nucleotide exchange factor 2


Q92835_C1050
INPP5D Phosphatidylinositol
8241



3,4,5-trisphosphate 5-



phosphatase 1


Q4G0F5_C334
VPS26B Vacuolar protein
8242



sorting-associated protein 26B


P17844_C234
DDX5 Probable ATP-
8243



dependent RNA helicase



DDX5


Q9BSD7_C101
NTPCR Cancer-related
8244



nucleoside-triphosphatase


Q92619_C1020
HMHA1 Minor
8245



histocompatibility protein HA-



1


Q14790_C360
CASP8 Caspase-8
8246


O15067_C1285
PFAS
8247



Phosphoribosylformylglycina



midine synthase


O15067_C1287
PFAS
8248



Phosphoribosylformylglycina



midine synthase


O60880_C124
SH2D1A SH2 domain-
8249



containing protein 1A


Q92888_C537
ARHGEF1 Rho guanine
8250



nucleotide exchange factor 1


O14879_C343
IFIT3 Interferon-induced
8251



protein with tetratricopeptide


Q93052_C364
LPP Lipoma-preferred partner
8252


P22695_C192
UQCRC2 Cytochrome b-c1
8253



complex subunit 2,



mitochondrial


P10398_C597
ARAF Serine/threonine-
8254



protein kinase A-Raf


P78347_C215
GTF2I General transcription
8255



factor II-I


P08575_C1259
PTPRC Receptor-type
8256



tyrosine-protein phosphatase C


Q9UHB9_C562
SRP68 Signal recognition
8257



particle 68 kDa protein


P40121_C290
CAPG Macrophage-capping
8258



protein


P36578_C250
RPL4 60S ribosomal protein
8259



L4


A9UHW6_C49
MIF4GD MIF4G domain-
8260



containing protein


Q9Y3B4_C83
SF3B14 Pre-mRNA branch
8261



site protein p14


Q93008_C1212
USP9X Probable ubiquitin
8262



carboxyl-terminal hydrolase



FAF


P11171_C179
EPB41 Protein 4.1
8263


Q9BZS1_C169
FOXP3 Forkhead box protein
8264



P3


Q13469_C256
NFATC2 Nuclear factor of
8265



activated T-cells, cytoplasmic



2


Q9BWW8_C25
APOL6 Apolipoprotein L6
8266


Q15366_C217
PCBP2 Poly(rC)-binding
8267



protein 2


P13796_C101
LCP1 Plastin-2
8268


Q16851_C123
UGP2 UTP--glucose-1-
8269



phosphate uridylyltransferase


P53602_C108
MVD Diphosphomevalonate
8270



decarboxylase


Q9NR30_C378
DDX21 Nucleolar RNA
8271



helicase 2


P13727_C201
PRG2 Bone marrow
8272



proteoglycan


O14867_C646
BACH1 Transcription
8273



regulator protein BACH1


O43772_C283
SLC25A20 Mitochondrial
8274



camitine/acylcamitine carrier



protein


Q9Y3F4_C305
STRAP Serine-threonine
8275



kinase receptor-associated



protein


Q12802_C1677
AKAP13 A-kinase anchor
8276



protein 13


Q9BSU1_C222
C16orf70 UPF0183 protein
8277



C16orf70


P78362_C320
SRPK2 SRSF protein kinase 2
8278


Q9NZJ7_C385
MTCH1 Mitochondrial carrier
8279



homolog 1


P51692_C688
STAT5B Signal transducer
8280



and activator of transcription 5


Q04637_C662
EIF4G1 Eukaryotic translation
8281



initiation factor 4 gamma 1


Q08AF3_C369
SLFN5 Schlafen family
8282



member 5


Q9NZB2_C919
FAM120A Constitutive
8283



coactivator of PPAR-gamma-



like protein 1


O60684_C238
KPNA6 Importin subunit
8284



alpha-7


O15131_C238
KPNA5 Importin subunit
8285



alpha-6


P52294_C240
KPNA1 Importin subunit
8286



alpha-1


Q8ND71_C214
GIMAP8 GTPase IMAP
8287



family member 8


P35658_C728
NUP214 Nuclear pore
8288



complex protein Nup214


Q32MZ4_C644
LRRFIP1 Leucine-rich repeat
8289



flightless-interacting protein


Q8TCU6_C1116
PREX1 Phosphatidylinositol
8290



3,4,5-trisphosphate-dependent


Q96I24_C460
FUBP3 Far upstream element-
8291



binding protein 3


Q6KC79_C1066
NIPBL Nipped-B-like protein
8292


Q03519_C353
TAP2 Antigen peptide
8293



transporter 2


Q7Z3K3_C547
POGZ Pogo transposable
8294



element with ZNF domain


Q7L8W6_C88
ATPBD4 ATP-binding
8295



domain-containing protein 4


Q9Y2Z0_C62
SUGT1 Suppressor of G2
8296



allele of SKP1 homolog


P34932_C376
HSPA4 Heat shock 70 kDa
8297



protein 4


Q92598_C376
HSPH1 Heat shock protein
8298



105 kDa


P17844_C221
DDX5 Probable ATP-
8299



dependent RNA helicase



DDX5


Q92841_C298
DDX17 Probable ATP-
8300



dependent RNA helicase



DDX17


Q5JSL3_C1204
DOCK11 Dedicator of
8301



cytokinesis protein 11


P09564_C230
CD7 T-cell antigen CD7
8302


P27635_C105
RPL10 60S ribosomal protein
8303



L10


Q9UKA8_C173
RCAN3 Calcipressin-3
8304


P00492_C106
HPRT1 Hypoxanthine-guanine
8305



phosphoribosyltransferase


P26038_C117
MSN Moesin
8306


P12955_C482
PEPD Xaa-Pro dipeptidase
8307


Q9NR33_C84
POLE4 DNA polymerase
8308



epsilon subunit 4


Q9H8W4_C219
PLEKHF2 Pleckstrin
8309



homology domain-containing



family F member


Q8WYP5_C1131
AHCTF1 Protein ELYS
8310


Q9Y6K5_C350
OAS3 2-5-oligoadenylate
8311



synthase 3


P41250_C616
GARS Glycine--tRNA ligase
8312


Q8NF50_C143
DOCK8 Dedicator of
8313



cytokinesis protein 8


H3BQZ7_C57
Uncharacterized protein
8314


Q1KMD3_C57
HNRNPUL2 Heterogeneous
8315



nuclear ribonucleoprotein U-



like protein


Q5JTH9_C102
RRP12 RRP12-like protein
8316


Q9C0C9_C910
UBE2O Ubiquitin-conjugating
8317



enzyme E2 O


Q9C0C9_C913
UBE2O Ubiquitin-conjugating
8318



enzyme E2 O


Q8NF50_C197
DOCK8 Dedicator of
8319



cytokinesis protein 8


O95466_C45
FMNL1 Formin-like protein 1
8320


Q53GL7_C50
PARP10 Polymerase
8321


Q9P2R3_C675
ANKFY1 Ankyrin repeat and
8322



FYVE domain-containing



protein


O75607_C105
NPM3 Nucleoplasmin-3
8323


Q9NXA8_C303
SIRT5 NAD-dependent
8324



protein deacylase sirtuin-5,



mitochondrial


Q00013_C454
MPP1 55 kDa erythrocyte
8325



membrane protein


O60701_C276
UGDH UDP-glucose 6-
8326



dehydrogenase


Q15149_C730
PLEC Plectin
8327


Q9Y4P8_C393
WIPI2 WD repeat domain
8328



phosphoinositide-interacting



protein


P27816_C126
MAP4 Microtubule-associated
8329



protein 4


O95487_C87
SEC24B Protein transport
8330



protein Sec24B


Q3SXM5_C265
HSDL1 Inactive
8331



hydroxysteroid



dehydrogenase-like protein


H3BQZ7_C293
Uncharacterized protein
8332


Q1KMD3_C293
HNRNPUL2 Heterogeneous
8333



nuclear ribonucleoprotein U-



like protein 2


P16871_C349
IL7R Interleukin-7 receptor
8334



subunit alpha


Q9HB90_C377
RRAGC Ras-related GTP-
8335



binding protein C


Q14919_C54
DRAP1 Dr1-associated
8336



corepressor


Q86YS7_C867
KIAA0528 Uncharacterized
8337



protein KIAA0528


P49915_C456
GMPS GMP synthase
8338


Q13428_C1298
TCOF1 Treacle protein
8339


Q9H9A6_C264
LRRC40 Leucine-rich repeat-
8340



containing protein 40


Q12802_C1548
AKAP13 A-kinase anchor
8341



protein 13


Q06330_C313
RBPJ Recombining binding
8342



protein suppressor of hairless


Q969E8_C17
TSR2 Pre-rRNA-processing
8343



protein TSR2 homolog


Q9ULT8_C254
HECTD1 E3 ubiquitin-protein
8344



ligase HECTD1


P51858_C12
HDGF Hepatoma-derived
8345



growth factor


Q99543_C394
DNAJC2 DnaJ homolog
8346



subfamily C member 2


P12268_C331
IMPDH2 Inosine-5-
8347



monophosphate



dehydrogenase 2


P42166_C341
TMPO Lamina-associated
8348



polypeptide 2, isoform alpha


Q92888_C911
ARHGEF1 Rho guanine
8349



nucleotide exchange factor 1


Q9BZ29_C628
DOCK9 Dedicator of
8350



cytokinesis protein 9


O95336_C78
PGLS 6-
8351



phosphogluconolactonase


Q9UEW8_C525
STK39 STE20/SPS1-related
8352



proline-alanine-rich protein



kinase


Q63HN8_C614
RNF213 E3 ubiquitin-protein
8353



ligase RNF213


P49023_C108
PXN Paxillin
8354


Q16666_C679
IFI16 Gamma-interferon-
8355



inducible protein 16


Q9Y5Y2_C196
NUBP2 Cytosolic Fe—S cluster
8356



assembly factor NUBP2


Q9Y5Y2_C202
NUBP2 Cytosolic Fe—S cluster
8357



assembly factor NUBP2


Q9GZR7_C49
DDX24 ATP-dependent RNA
8358



helicase DDX24


Q96F63_C78
CCDC97 Coiled-coil domain-
8359



containing protein 97


Q9Y5Y2_C199
NUBP2 Cytosolic Fe—S cluster
8360



assembly factor NUBP2


Q96F07_C1112
CYFIP2 Cytoplasmic FMR1-
8361



interacting protein 2


Q9UPU5_C153
USP24 Ubiquitin carboxyl-
8362



terminal hydrolase 24


P02545_C570
LMNA Prelamin-A/C
8363


Q7L576_C1088
CYF1P1 Cytoplasmic FMR1-
8364



interacting protein 1


O95671_C333
ASMTL N-acetylserotonin O-
8365



methyltransferase-like protein


Q7Z6B0_C424
CCDC91 Coiled-coil domain-
8366



containing protein 91


P49321_C708
NASP Nuclear autoantigenic
8367



sperm protein


P61978_C132
HNRNPK Heterogeneous
8368



nuclear ribonucleoprotein K


P42224_C255
STAT1 Signal transducer and
8369



activator of transcription 1


Q01518_C427
CAP1 Adenylyl cyclase-
8370



associated protein 1


O94874_C32
UFL1 E3 UFM1-protein ligase
8371



1


P42224_C247
STAT1 Signal transducer and
8372



activator of transcription 1


Q96BY6_C2164
DOCK10 Dedicator of
8373



cytokinesis protein 10


O43586_C305
PSTPIP1 Proline-serine-
8374



threonine phosphatase-



interacting protein 1


P50851_C1704
LRBA Lipopolysaccharide-
8375



responsive and beige-like



anchor protein


Q96QR8_C17
PURB Transcriptional
8376



activator protein Pur-beta


Q9H3H3_C222
C11orf68 UPF0696 protein
8377



C11orf68


Q14997_C1840
PSME4 Proteasome activator
8378



complex subunit 4


Q9BUP3_C172
HTATIP2 Oxidoreductase
8379



HTATIP2


Q5VSL9_C769
FAM40A Protein FAM40A
8380


Q9NW68_C49
BSDC1 BSD domain-
8381



containing protein 1


Q96F07_C1265
CYFIP2 Cytoplasmic FMR1-
8382



interacting protein 2


P60468_C39
SEC61B Protein transport
8383



protein Sec61 subunit beta


Q15061_C380
WDR43 WD repeat-containing
8384



protein 43


Q04759_C322
PRKCQ Protein kinase C theta
8385



type


Q13615_C826
MTMR3 Myotubularin-related
8386



protein 3


Q13630_C116
TSTA3 GDP-L-fucose
8387



synthase


Q9Y6R4_C1604
MAP3K4 Mitogen-activated
8388



protein kinase kinase kinase 4


P49711_C155
CTCF Transcriptional
8389



repressor CTCF


Q9UPS6_C1405
SETD1B Histone-lysine N-
8390



methyltransferase SETD1B


Q8WVT3_C160
TRAPPC12 Trafficking
8391



protein particle complex



subunit 12


P55060_C842
CSE1L Exportin-2
8392


Q9BSJ8_C611
ESYT1 Extended
8393



synaptotagmin-1


P52948_C1027
NUP98 Nuclear pore complex
8394



protein Nup98-Nup96


P50991_C120
CCT4 T-complex protein 1
8395



subunit delta


Q13107_C702
USP4 Ubiquitin carboxyl-
8396



terminal hydrolase 4


P22681_C508
CBL E3 ubiquitin-protein
8397



ligase CBL


Q08117_C26
AES Amino-terminal enhancer
8398



of split


P19784_C336
CSNK2A2 Casein kinase II
8399



subunit alpha


Q16576_C97
RBBP7 Histone-binding
8400



protein RBBP7


Q8NBF2_C716
NHLRC2 NHL repeat-
8401



containing protein 2


Q00403_C223
GTF2B Transcription
8402



initiation factor IIB


P46527_C148
CDKN1B Cyclin-dependent
8403



kinase inhibitor 1B


P17844_C191
DDX5 Probable ATP-
8404



dependent RNA helicase



DDX5


P22061_C102
PCMT1 Protein-L-
8405



isoaspartate(D-aspartate) O-



methyltransferase


P35611_C430
ADD1 Alpha-adducin
8406


P52888_C682
THOP1 Thimet oligopeptidase
8407


Q01081_C67
U2AF1 Splicing factor U2AF
8408



35 kDa subunit


Q96BY9_C320
TMEM66 Store-operated
8409



calcium entry-associated



regulatory


Q14152_C78
EIF3A Eukaryotic translation
8410



initiation factor 3 subunit


P13489_C409
RNH1 Ribonuclease inhibitor
8411


Q07960_C91
ARHGAP1 Rho GTPase-
8412



activating protein 1


Q9UGP4_C305
LIMD1 LIM domain-
8413



containing protein 1


P27816_C535
MAP4 Microtubule-associated
8414



protein 4


Q8NCE2_C182
MTMR14 Myotubularin-
8415



related protein 14


O00273_C154
DFFA DNA fragmentation
8416



factor subunit alpha


Q92973_C153
TNPO1 Transportin-1
8417


P51608_C413
MECP2 Methyl-CpG-binding
8418



protein 2


Q63HN8_C3008
RNF213 E3 ubiquitin-protein
8419



ligase RNF213


O15294_C620
OGT UDP-N-
8420



acetylglucosamine--peptide N-



acetylglucosaminyl transferase


P42166_C561
TMPO Lamina-associated
8421



polypeptide 2, isoform alpha


Q6F5E8_C746
RLTPR Leucine-rich repeat-
8422



containing protein 16C


P55265_C392
ADAR Double-stranded RNA-
8423



specific adenosine deaminase


Q8NB37_C154
PDDC1 Parkinson disease 7
8424



domain-containing protein 1


Q6JBY9_C155
RCSD1 CapZ-interacting
8425



protein


Q9UJU2_C321
LEF1 Lymphoid enhancer-
8426



binding factor 1


O00186_C501
STXBP3 Syntaxin-binding
8427



protein 3


Q96BY6_C1310
DOCK10 Dedicator of
8428



cytokinesis protein 10


O00186_C498
STXBP3 Syntaxin-binding
8429



protein 3


P63104_C25
YWHAZ 14-3-3 protein
8430



zeta/delta


Q8WU79_C196
SMAP2 Stromal membrane-
8431



associated protein 2


Q00765_C18
REEP5 Receptor expression-
8432



enhancing protein 5


P51608_C429
MECP2 Methyl-CpG-binding
8433



protein 2


O60841_C749
EIF5B Eukaryotic translation
8434



initiation factor 5B


P42331_C524
ARHGAP25 Rho GTPase-
8435



activating protein 25


P35579_C988
MYH9 Myosin-9
8436


Q14151_C672
SAFB2 Scaffold attachment
8437



factor B2


Q99490_C811
AGAP2 Arf-GAP with
8438



GTPase, ANK repeat and PH



domain-containing protein 2


O60307_C762
MAST3 Microtubule-
8439



associated serine/threonine-



protein ki


P27707_C9
DCK Deoxycytidine kinase
8440


Q99704_C308
DOK1 Docking protein 1
8441


O75940_C214
SMNDC1 Survival of motor
8442



neuron-related-splicing factor



3


O15269_C438
SPTLC1 Serine
8443



palmitoyltransferase 1


Q5EBM0_C119
CMPK2 UMP-CMP kinase 2,
8444



mitochondrial


Q96F86_C137
EDC3 Enhancer of mRNA-
8445



decapping protein 3


Q86YV0_C1005
RASAL3 RAS protein
8446



activator like-3


P30044_C204
PRDX5 Peroxiredoxin-5,
8447



mitochondrial


P78527_C1904
PRKDC DNA-dependent
8448



protein kinase catalytic subunit


Q9BXP2_C911
SLC12A9 Solute carrier
8449



family 12 member 9


Q9Y6G9_C51
DYNC1LI1 Cytoplasmic
8450



dynein 1 light intermediate



chain 1


Q12962_C174
TAF10 Transcription initiation
8451



factor TFIID subunit 10


Q8IV53_C412
DENND1C DENN domain-
8452



containing protein 1C


Q8NFW8_C364
CMAS N-acylneuraminate
8453



cytidylyltransferase


Q7Z4S6_C299
KIF21A Kinesin-like protein
8454



KIF21A


Q9Y383_C348
LUC7L2 Putative RNA-
8455



binding protein Luc7-like 2


Q12768_C21
KLAA0196 WASH complex
8456



subunit strumpellin


Q9ULX6_C211
AKAP8L A-kinase anchor
8457



protein 8-like


Q2NKJ3_C584
CTC1 CST complex subunit
8458



CTC1


Q7Z4W1_C138
DCXR L-xylulose reductase
8459


P78527_C1507
PRKDC DNA-dependent
8460



protein kinase catalytic subunit


Q9NQC3_C1101
RTN4 Reticulon-4
8461


Q8NCE2_C429
MTMR14 Myotubularin-
8462



related protein 14


P41227_C194
NAA10 N-alpha-
8463



acetyltransferase 10


Q08AF3_C846
SLFN5 Schlafen family
8464



member 5


Q9NXG2_C31
THUMPD1 THUMP domain-
8465



containing protein 1


Q00722_C945
PLCB2 1-phosphatidylinositol
8466



4,5-bisphosphate



phosphodiesterase beta-2


Q14694_C94
USP10 Ubiquitin carboxyl-
8467



terminal hydrolase 10


Q12933_C287
TRAF2 TNF receptor-
8468



associated factor 2


P14735_C974
IDE Insulin-degrading enzyme
8469


P32456_C405
GBP2 Interferon-induced
8470



guanylate-binding protein 2


P32456_C404
GBP2 Interferon-induced
8471



guanylate-binding protein 2


Q6PJG6_C539
BRAT1 BRCA1-associated
8472



ATM activator 1


Q9NPG8_C337
ZDHHC4 Probable
8473



palmitoyltransferase ZDHHC4


Q9Y2K7_C840
KDM2A Lysine-specific
8474



demethylase 2A


P12081_C507
HARS Histidine--tRNA ligase,
8475



cytoplasmic


Q13469_C231
NFATC2 Nuclear factor of
8476



activated T-cells, cytoplasmic



2


Q16611_C14
BAK1 Bcl-2 homologous
8477



antagonist/killer


P35579_C931
MYH9 Myosin-9
8478


Q9UFW8_C92
CGGBP1 CGG triplet repeat-
8479



binding protein 1


P11171_C49
EPB41 Protein 4.1
8480


Q9UQ35_C2116
SRRM2 Serine/arginine
8481



repetitive matrix protein 2


Q8WXI9_C308
GATAD2B Transcriptional
8482



repressor p66-beta


Q96EY8_C132
MMAB Cob(I)yrinic acid a,c-
8483



diamide adenosyltransferase,



mitochondrial


Q01433_C107
AMPD2 AMP deaminase 2
8484


Q9H0L4_C150
CSTF2T Cleavage stimulation
8485



factor subunit 2 tau variant


P16188_C363
HLA-A HLA class I histocompatibility
8486



antigen, A-30 alpha


P04439_C363
HLA-A HLA class I histocompatibility
8487



antigen, A-3 alpha


P30443_C363
HLA-A HLA class I histocompatibility
8488



antigen, A-1 alpha


O75663_C87
TIPRL TIP41-like protein
8489


P19838_C61
NFKB1 Nuclear factor NF-
8490



kappa-B p105 subunit


P07858_C319
CTSB Cathepsin B
8491


O60502_C596
MGEA5 Bifunctional protein
8492



NCOAT


Q9HB58_C283
SP110 Sp110 nuclear body
8493



protein


P21333_C2543
FLNA Filamin-A
8494


Q9BTE6_C209
AARSD1 Alanyl-tRNA
8495



editing protein Aarsd1


Q04864_C524
REL Proto-oncogene c-Rel
8496


O75400_C39
PRPF40A Pre-mRNA-
8497



processing factor 40 homolog



A


P04150_C367
NR3C1 Glucocorticoid
8498



receptor


P33241_C283
LSP1 Lymphocyte-specific
8499



protein 1


O60934_C487
NBN Nibrin
8500


Q86W50_C448
METTL16 Methyltransferase-
8501



like protein 16


Q9UQ35_C872
SRRM2 Serine/arginine
8502



repetitive matrix protein 2


Q8NDH3_C81
NPEPL1 Probable
8503



aminopeptidase NPEPL1


O43815_C765
STRN Striatin
8504


O15145_C162
ARPC3 Actin-related protein
8505



2/3 complex subunit 3


O15355_C164
PPM1G Protein phosphatase
8506



1G


H3BQZ7_C308
Uncharacterized protein
8507


Q1KMD3_C308
HNRNPUL2 Heterogeneous
8508



nuclear ribonucleoprotein U-



like protein


Q9NQ88_C114
TIGAR Fructose-2,6-
8509



bisphosphatase TIGAR


P23497_C309
SP100 Nuclear autoantigen
8510



Sp-100


A2A288_C367
ZC3H12D Probable
8511



ribonuclease ZC3H12D


Q9C0B6_C491
FAM5B Protein FAM5B
8512


Q9UJW0_C258
DCTN4 Dynactin subunit 4
8513


P05771_C217
PRKCB Protein kinase C beta
8514



type


Q96RS6_C376
NUDCD1 NudC domain-
8515



containing protein 1


Q8TD19_C878
NEK9 Serine/threonine-
8516



protein kinase Nek9


O95786_C680
DDX58 Probable ATP-
8517



dependent RNA helicase



DDX58


O94763_C44
URI1 Unconventional
8518



prefoldin RPB5 interactor 1


Q6PCB5_C280
RSBN1L Round spermatid
8519



basic protein 1-like protein


Q09666_C1833
AHNAK Neuroblast
8520



differentiation-associated



protein AHNA


O95861_C42
BPNT1 3(2),5-bisphosphate
8521



nucleotidase 1


Q96B23_C57
C18orf25 Uncharacterized
8522



protein C18orf25


Q9UER7_C699
DAXX Death domain-
8523



associated protein 6


Q7Z6I6_C954
ARHGAP30 Rho GTPase-
8524



activating protein 30


Q9P107_C335
GMIP GEM-interacting
8525



protein


Q06323_C22
PSME1 Proteasome activator
8526



complex subunit 1


Q9P107_C336
GMIP GEM-interacting
8527



protein


P35579_C569
MYH9 Myosin-9
8528


P13489_C75
RNH1 Ribonuclease inhibitor
8529


Q9NY27_C22
PPP4R2 Serine/threonine-
8530



protein phosphatase 4



regulatory


Q8NFH5_C255
NUP35 Nucleoporin NUP53
8531


P13489_C85
RNH1 Ribonuclease inhibitor
8532


Q00610_C870
CLTC Clathrin heavy chain 1
8533


O95071_C2267
UBR5 E3 ubiquitin-protein
8534



ligase UBR5


Q6NZY4_C393
ZCCHC8 Zinc finger CCHC
8535



domain-containing protein 8


A6QL63_C783
BTBD11 Ankyrin repeat and
8536



BTB/POZ domain-containing



protein


Q09666_C1900
AHNAK Neuroblast
8537



differentiation-associated



protein AHNA


Q09161_C44
NCBP1 Nuclear cap-binding
8538



protein subunit 1


Q5JSP0_C43
FGD3 FYVE, RhoGEF and
8539



PH domain-containing protein



3


Q14839_C1594
CHD4 Chromodomain-
8540



helicase-DNA-binding protein



4


Q16566_C202
CAMK4 Calcium/calmodulin-
8541



dependent protein kinase type



1


Q8WTW3_C513
COG1 Conserved oligomeric
8542



Golgi complex subunit 1


Q09666_C2162
AHNAK Neuroblast
8543



differentiation-associated



protein AHNA


Q9HA64_C24
FN3KRP Ketosamine-3-kinase
8544


Q96E39_C338
RBMXL1 RNA binding motif
8545



protein, X-linked-like-1


P35610_C92
SOAT1 Sterol O-
8546



acyltransferase 1


Q96T76_C549
MMS19 MMS19 nucleotide
8547



excision repair protein



homolog


Q9H4A3_C547
WNK1 Serine/threonine-
8548



protein kinase WNK1


Q7Z2T5_C320
TRMT1L TRMT1-like protein
8549


Q99996_C3868
AKAP9 A-kinase anchor
8550



protein 9


Q96RU3_C70
FNBP1 Formin-binding
8551



protein 1


Q9H9A6_C54
LRRC40 Leucine-rich repeat-
8552



containing protein 40


O75569_C106
PRKRA Interferon-inducible
8553



double stranded RNA-



dependent


P04150_C302
NR3C1 Glucocorticoid
8554



receptor


Q9NUQ9_C10
FAM49B Protein FAM49B
8555


P20592_C707
MX2 Interferon-induced GTP-
8556



binding protein Mx2


Q8N5K1_C92
CISD2 CDGSH iron-sulfur
8557



domain-containing protein 2


O14497_C336
ARID1A AT-rich interactive
8558



domain-containing protein 1A


O75694_C874
NUP155 Nuclear pore
8559



complex protein Nup155


Q5W0V3_C298
FAM160B1 Protein
8560



FAM160B1


Q9NSD9_C195
FARSB Phenylalanine--tRNA
8561



ligase beta subunit


P45984_C177
MAPK9 Mitogen-activated
8562



protein kinase 9


Q92835_C956
INPP5D Phosphatidylinositol
8563



3,4,5-trisphosphate 5-



phosphatase


Q96EV2_C726
RBM33 RNA-binding protein
8564



33


P55198_C571
MLLT6 Protein AF-17
8565


O75475_C204
PSIP1 PC4 and SFRS1-
8566



interacting protein


P51812_C229
RPS6KA3 Ribosomal protein
8567



S6 kinase alpha-3


Q15418_C223
RPS6KA1 Ribosomal protein
8568



S6 kinase alpha-1


O94886_C791
TMEM63A Transmembrane
8569



protein 63A


Q14005_C975
IL16 Pro-interleukin-16
8570


P13639_C41
EEF2 Elongation factor 2
8571


Q63HN8_C310
RNF213 E3 ubiquitin-protein
8572



ligase RNF213


Q96QD9_C242
FYTTD1 UAP56-interacting
8573



factor


P07814_C744
EPRS Bifunctional
8574



glutamate/proline--tRNA



ligase


Q9UKT9_C434
IKZF3 Zinc finger protein
8575



Aiolos


Q8TC07_C197
TBC1D15 TBC1 domain
8576



family member 15


Q96RU3_C511
FNBP1 Formin-binding
8577



protein 1


Q9NUP9_C47
LIN7C Protein lin-7 homolog
8578



C


Q9ULP9_C89
TBC1D24 TBC1 domain
8579



family member 24


H3BQ06_C89
Uncharacterized protein
8580


P28702_C340
RXRB Retinoic acid receptor
8581



RXR-beta


Q9UL15_C327
BAG5 BAG family molecular
8582



chaperone regulator 5


O95817_C179
BAG3 BAG family molecular
8583



chaperone regulator 3


Q86UT6_C331
NLRX1 NLR family member
8584



X1


Q96PE3_C854
INPP4A Type I inositol 3,4-
8585



bisphosphate 4-phosphatase


P57764_C268
GSDMD Gasdermin-D
8586


Q99873_C109
PRMT1 Protein arginine N-
8587



methyltransferase 1


P49589_C27
CARS Cysteine--tRNA ligase,
8588



cytoplasmic


P53384_C31
NUBP1 Cytosolic Fe—S cluster
8589



assembly factor NUBP1


O95644_C228
NFATC1 Nuclear factor of
8590



activated T-cells, cytoplasmic



1


Q9UPN7_C795
PPP6R1 Serine/threonine-
8591



protein phosphatase 6



regulatory


Q93008_C673
USP9X Probable ubiquitin
8592



carboxyl-terminal hydrolase



FAF


O00507_C674
USP9Y Probable ubiquitin
8593



carboxyl-terminal hydrolase



FAF


Q9UHI6_C577
DDX20 Probable ATP-
8594



dependent RNA helicase



DDX20


Q09666_C108
AHNAK Neuroblast
8595



differentiation-associated



protein AHNA


O43290_C674
SART1 U4/U6.U5 tri-snRNP-
8596



associated protein 1


Q2NL82_C126
TSR1 Pre-rRNA-processing
8597



protein TSR1 homolog


Q9UPN3_C4825
MACF1 Microtubule-actin
8598



cross-linking factor 1,



isoforms


Q13588_C161
GRAP GRB2-related adapter
8599



protein


Q9UG22_C227
GIMAP2 GTPase IMAP
8600



family member 2


I3L420_C73
LSM14A Protein LSM14
8601



homolog A


Q8ND56_C78
LSM14A Protein LSM14
8602



homolog A


Q96CM8_C64
ACSF2 Acyl-CoA synthetase
8603



family member 2,



mitochondrial


Q6Y7W6_C938
GIGYF2 PERQ amino acid-
8604



rich with GYF domain-



containing protein


Q9HB58_C327
SP110 Sp110 nuclear body
8605



protein


Q9UGP4_C374
LIMD1 LIM domain-
8606



containing protein 1


P49458_C48
SRP9 Signal recognition
8607



particle 9 kDa protein


O43566_C496
RGS14 Regulator of G-protein
8608



signaling 14


P21333_C717
FLNA Filamin-A
8609


Q9NZB2_C279
FAM120A Constitutive
8610



coactivator of PPAR-gamma-



like protein 1


Q96EB1_C218
ELP4 Elongator complex
8611



protein 4


O43149_C2312
ZZEF1 Zinc finger ZZ-type
8612



and EF-hand domain-



containing


Q0VD83_C844
APOBR Apolipoprotein B
8613



receptor


Q00537_C127
CDK17 Cyclin-dependent
8614



kinase 17


Q9UJY4_C429
GGA2 ADP-ribosylation
8615



factor-binding protein GGA2


Q03519_C641
TAP2 Antigen peptide
8616



transporter 2


Q9P2X3_C195
IMPACT Protein IMPACT
8617


P42166_C684
TMPO Lamina-associated
8618



polypeptide 2, isoform alpha


Q5GLZ8_C392
HERC4 Probable E3
8619



ubiquitin-protein ligase



HERC4


Q9H832_C100
UBE2Z Ubiquitin-conjugating
8620



enzyme E2 Z


P36969_C93
GPX4 Phospholipid
8621



hydroperoxide glutathione



peroxidase, mitochondrial


Q9NVG8_C36
TBC1D13 TBC1 domain
8622



family member 13


O75348_C69
ATP6V1G1 V-type proton
8623



ATPase subunit G 1


Q99575_C705
POP1 Ribonucleases P/MRP
8624



protein subunit POP1


O75369_C2501
FLNB Filamin-B
8625


P50851_C2675
LRBA Lipopolysaccharide-
8626



responsive and beige-like



anchor protein


Q99575_C706
POP1 Ribonucleases P/MRP
8627



protein subunit POP1


Q99704_C115
DOK1 Docking protein 1
8628


Q05086_C108
UBE3A Ubiquitin-protein
8629



ligase E3A


Q15052_C553
ARHGEF6 Rho guanine
8630



nucleotide exchange factor 6


Q9C0B7_C286
TMCO7 Transmembrane and
8631



coiled-coil domain-containing



protein


Q9Y2X7_C576
GIT1 ARF GTPase-activating
8632



protein GIT1


Q66PJ3_C349
ARL6IP4 ADP-ribosylation
8633



factor-like protein 6-



interacting protein 4


Q99497_C46
PARK7 Protein DJ-1
8634


Q9UIS9_C525
MBD1 Methyl-CpG-binding
8635



domain protein 1


Q8IWX8_C69
CHERP Calcium homeostasis
8636



endoplasmic reticulum protein


Q00577_C292
PURA Transcriptional
8637



activator protein Pur-alpha


P62249_C25
RPS16 40S ribosomal protein
8638



S16


Q9UJX3_C131
ANAPC7 Anaphase-
8639



promoting complex subunit 7


Q5VTL8_C113
PRPF38B Pre-mRNA-splicing
8640



factor 38B


P47756_C206
CAPZB F-actin-capping
8641



protein subunit beta


Q562E7_C198
WDR81 WD repeat-containing
8642



protein 81


Q8IV50_C106
LYSMD2 LysM and putative
8643



peptidoglycan-binding



domain-containing 2


Q96F15_C171
GIMAP5 GTPase IMAP
8644



family member 5


Q9P253_C22
VPS18 Vacuolar protein
8645



sorting-associated protein 18



homolog


Q562E7_C187
WDR81 WD repeat-containing
8646



protein 81


Q6KC79_C419
NIPBL Nipped-B-like protein
8647


Q9BSJ8_C635
ESYT1 Extended
8648



synaptotagmin-1


Q14980_C160
NUMA1 Nuclear mitotic
8649



apparatus protein 1


O00571_C128
DDX3X ATP-dependent RNA
8650



helicase DDX3X


Q96FZ5_C12
CMTM7 CKLF-like
8651



MARVEL transmembrane



domain-containing protein


Q8TCU6_C52
PREX1 Phosphatidylinositol
8652



3,4,5-trisphosphate-dependent


Q9Y6K9_C131
IKBKG NF-kappa-B essential
8653



modulator


O14497_C1968
ARID1A AT-rich interactive
8654



domain-containing protein 1A


Q9NYF8_C688
BCLAF1 Bcl-2-associated
8655



transcription factor 1


Q96SK2_C301
TMEM209 Transmembrane
8656



protein 209


Q15424_C519
SAFB Scaffold attachment
8657



factor B1


P52564_C38
MAP2K6 Dual specificity
8658



mitogen-activated protein



kinase


P08575_C398
PTPRC Receptor-type
8659



tyrosine-protein phosphatase C


Q9NUW8_C135
TDP1 Tyrosyl-DNA
8660



phosphodiesterase 1


E9PMF8_C332
PTPRC Receptor-type
8661



tyrosine-protein phosphatase C


Q9Y4W2_C140
LAS1L Ribosomal biogenesis
8662



protein LAS1L


P04843_C477
RPN1 Dolichyl-
8663



diphosphooligosaccharide--



protein glycosyltransferase



subunit 1


Q9UFC0_C249
LRWD1 Leucine-rich repeat
8664



and WD repeat-containing



protein


Q9NUW8_C48
TDP1 Tyrosyl-DNA
8665



phosphodiesterase 1


Q15052_C564
ARHGEF6 Rho guanine
8666



nucleotide exchange factor 6


Q02543_C22
RPL18A 60S ribosomal
8667



protein L18a


A0FGR8_C181
ESYT2 Extended
8668



synaptotagmin-2


Q9BTA9_C553
WAC WW domain-containing
8669



adapter protein with coiled-



coil


Q14980_C961
NUMA1 Nuclear mitotic
8670



apparatus protein 1


Q9BUH6_C180
C9orf142 Uncharacterized
8671



protein C9orf142


P43250_C138
GRK6 G protein-coupled
8672



receptor kinase 6


Q15185_C58
PTGES3 Prostaglandin E
8673



synthase 3


Q8N4N3_C523
KLHL36 Kelch-like protein 36
8674


Q15669_C165
RHOH Rho-related GTP-
8675



binding protein RhoH


Q9NZT2_C443
OGFR Opioid growth factor
8676



receptor


Q13542_C35
EIF4EBP2 Eukaryotic
8677



translation initiation factor 4E-



binding protein 2


Q15669_C108
RHOH Rho-related GTP-
8678



binding protein RhoH


Q92835_C138
INPP5D Phosphatidylinositol
8679



3,4,5-trisphosphate 5-



phosphatase


Q6PKG0_C864
LARP1 La-related protein 1
8680


Q9Y679_C391
AUP1 Ancient ubiquitous
8681



protein 1


P36542_C103
ATP5C1 ATP synthase
8682



subunit gamma, mitochondrial


Q01664_C29
TFAP4 Transcription factor
8683



AP-4


P38606_C138
ATP6V1A V-type proton
8684



ATPase catalytic subunit A


Q9Y520_C223
PRRC2C Protein PRRC2C
8685


Q7Z2Z2_C474
EFTUD1 Elongation factor Tu
8686



GTP-binding domain-



containing


O15294_C758
OGT UDP-N-
8687



acetylglucosamine--peptide N-



acetylglucosaminyl transferase


Q96S59_C638
RANBP9 Ran-binding protein
8688



9


O00541_C272
PES1 Pescadillo homolog
8689


Q15020_C670
SART3 Squamous cell
8690



carcinoma antigen recognized



by T-cells 3


Q8NF91_C8703
SYNE1 Nesprin-1
8691


Q14966_C1279
ZNF638 Zinc finger protein
8692



638


Q96C19_C172
EFHD2 EF-hand domain-
8693



containing protein D2


O75688_C172
PPM1B Protein phosphatase
8694



1B


Q05519_C455
SRSF11 Serine/arginine-rich
8695



splicing factor 11


P42331_C448
ARHGAP25 Rho GTPase-
8696



activating protein 25


P57075_C371
UBASH3A Ubiquitin-
8697



associated and SH3 domain-



containing protein


Q96GX2_C75
ATXN7L3B Putative ataxin-7-
8698



like protein 3B


Q14690_C361
PDCD11 Protein RRP5
8699



homolog


Q15149_C4494
PLEC Plectin
8700


Q9NP31_C34
SH2D2A SH2 domain-
8701



containing protein 2A


P30519_C282
HMOX2 Heme oxygenase 2
8702


P98171_C855
ARHGAP4 Rho GTPase-
8703



activating protein 4


I3L420_C80
LSM14A Protein LSM14
8704



homolog A


Q8ND56_C85
LSM14A Protein LSM14
8705



homolog A


P21580_C590
TNFAIP3 Tumor necrosis
8706



factor alpha-induced protein 3


O14618_C244
CCS Copper chaperone for
8707



superoxide dismutase


Q06124_C573
PTPN11 Tyrosine-protein
8708



phosphatase non-receptor type



11


P08240_C253
SRPR Signal recognition
8709



particle receptor subunit alpha


O14618_C246
CCS Copper chaperone for
8710



superoxide dismutase


Q9H2M9_C67
RAB3GAP2 Rab3 GTPase-
8711



activating protein non-catalytic



subunit


Q06124_C567
PTPN11 Tyrosine-protein
8712



phosphatase non-receptor type



11


O43865_C272
AHCYL1 Putative
8713



adenosylhomocysteinase 2


Q96HN2_C353
AHCYL2 Putative
8714



adenosylhomocysteinase 3


P41226_C599
UBA7 Ubiquitin-like
8715



modifier-activating enzyme 7


Q06203_C100
PPAT
8716



Amidophosphoribosyltransferase


Q96F07_C98
CYFIP2 Cytoplasmic FMR1-
8717



interacting protein 2


O60610_C1227
DIAPH1 Protein diaphanous
8718



homolog 1


Q9Y266_C188
NUDC Nuclear migration
8719



protein nudC


Q7L576_C98
CYFIP1 Cytoplasmic FMR1-
8720



interacting protein 1


Q9H5N1_C422
RABEP2 Rab GTPase-binding
8721



effector protein 2


Q9H5N1_C423
RABEP2 Rab GTPase-binding
8722



effector protein 2


Q13501_C289
SQSTM1 Sequestosome-1
8723


Q02446_C55
SP4 Transcription factor Sp4
8724


O43175_C369
PHGDH D-3-
8725



phosphoglycerate



dehydrogenase


Q93008_C1237
USP9X Probable ubiquitin
8726



carboxyl-terminal hydrolase



FAF


O00507_C1238
USP9Y Probable ubiquitin
8727



carboxyl-terminal hydrolase



FAF


Q8TD19_C11
NEK9 Serine/threonine-
8728



protein kinase Nek9


Q6ZRI6_C367
C15orf39 Uncharacterized
8729



protein C15orf39


P40763_C718
STAT3 Signal transducer and
8730



activator of transcription 3


Q15723_C470
ELF2 ETS-related
8731



transcription factor Elf-2


Q8IWZ3_C615
ANKHD1 Ankyrin repeat and
8732



KH domain-containing protein



1


O60664_C60
PLIN3 Perilipin-3
8733


Q09666_C5502
AHNAK Neuroblast
8734



differentiation-associated



protein AHNA


Q8IV63_C191
VRK3 Inactive
8735



serine/threonine-protein kinase



VRK3


E7EQZ4_C146
SMN1 Survival motor neuron
8736



protein


Q16637_C146
SMN2 Survival motor neuron
8737



protein


Q8IWV7_C1603
UBR1 E3 ubiquitin-protein
8738



ligase UBR1


O14981_C936
BTAF1 TATA-binding
8739



protein-associated factor 172


Q07352_C34
ZEP36L1 Zinc finger protein
8740



36, C3H1 type-like 1


P25205_C119
MCM3 DNA replication
8741



licensing factor MCM3


P35579_C1437
MYH9 Myosin-9
8742


Q8NF50_C2091
DOCK8 Dedicator of
8743



cytokinesis protein 8


P42224_C492
STAT1 Signal transducer and
8744



activator of transcription 1


O96008_C74
TOMM40 Mitochondrial
8745



import receptor subunit



TOM40 homolog


O96008_C76
TOMM40 Mitochondrial
8746



import receptor subunit



TOM40 homolog


P46063_C606
RECQL ATP-dependent DNA
8747



helicase Q1


Q9NVE7_C537
PANK4 Pantothenate kinase 4
8748


O15371_C195
E1F3D Eukaryotic translation
8749



initiation factor 3 subunit


P45880_C47
VDAC2 Voltage-dependent
8750



anion-selective channel protein


Q8IZ07_C540
ANKRD13A Ankyrin repeat
8751



domain-containing protein



13A


P49795_C73
RGS19 Regulator of G-protein
8752



signaling 19


P49795_C76
RGS19 Regulator of G-protein
8753



signaling 19


Q69YN2_C288
CWF19L1 CWF19-like
8754



protein 1


Q53ET0_C515
CRTC2 CREB-regulated
8755



transcription coactivator 2


P78371_C412
CCT2 T-complex protein 1
8756



subunit beta


Q99961_C277
SH3GL1 Endophilin-A2
8757


P33241_C36
LSP1 Lymphocyte-specific
8758



protein 1


Q8NFI3_C113
ENGASE Cytosolic endo-
8759



beta-N-acetylglucosaminidase


Q9BXJ9_C238
NAA15 N-alpha-
8760



acetyltransferase 15, NatA



auxiliary subunit


Q92570_C301
NR4A3 Nuclear receptor
8761



subfamily 4 group A member



3


I3L097_C251
Uncharacterized protein
8762


Q9H6R4_C1034
NOL6 Nucleolar protein 6
8763


O94992_C79
HEXIM1 Protein HEXIM1
8764


Q8N0X7_C504
SPG20 Spartin
8765


O94992_C84
HEXIM1 Protein HEXIM1
8766


Q96HE7_C166
ERO1L ERO1-like protein
8767



alpha


Q9GZU8_C187
FAM192A Protein FAM192A
8768


Q9UKA4_C1232
AKAP11 A-kinase anchor
8769



protein 11


P42224_C155
STAT1 Signal transducer and
8770



activator of transcription 1


P42166_C280
TMPO Lamina-associated
8771



polypeptide 2, isoform alpha


I3L1I5_C129
Uncharacterized protein
8772


Q15052_C25
ARHGEF6 Rho guanine
8773



nucleotide exchange factor 6


O95267_C615
RASGRP1 RAS guanyl-
8774



releasing protein 1


Q9P258_C428
RCC2 Protein RCC2
8775


Q7L1Q6_C35
BZW1 Basic leucine zipper
8776



and W2 domain-containing



protein


Q63HN8_C1510
RNF213 E3 ubiquitin-protein
8777



ligase RNF213


Q9Y2X3_C439
NOP58 Nucleolar protein 58
8778


P53384_C25
NUBP1 Cytosolic Fe—S cluster
8779



assembly factor NUBP1


O15054_C1205
KDM6B Lysine-specific
8780



demethylase 6B


Q96BY6_C321
DOCK10 Dedicator of
8781



cytokinesis protein 10


Q96BY6_C319
DOCK10 Dedicator of
8782



cytokinesis protein 10


P01892_C363
HLA-A HLA class I histocompatibility
8783



antigen, A-2 alpha


P01891_C363
HLA-A HLA class I histocompatibility
8784



antigen, A-68 alpha


P49327_C1448
FASN Fatty acid synthase
8785


Q8ND24_C655
RNF214 RING finger protein
8786



214


Q9P2E3_C1822
ZNFX1 NFX1-type zinc
8787



finger-containing protein 1


Q9Y5K6_C540
CD2AP CD2-associated
8788



protein


Q13459_C1279
MYO9B Unconventional
8789



myosin-IXb


O15355_C241
PPM1G Protein phosphatase
8790



1G


Q8IV53_C174
DENND1C DENN domain-
8791



containing protein 1C


Q6JBY9_C181
RCSD1 CapZ-interacting
8792



protein


Q8IU85_C354
CAMK1D
8793



Calcium/calmodulin-



dependent protein kinase type



1


O95644_C209
NFATC1 Nuclear factor of
8794



activated T-cells, cytoplasmic



1


Q92576_C885
PHF3 PHD finger protein 3
8795


Q5T440_C170
IBA57 Putative transferase
8796



CAF17, mitochondrial


P30519_C265
HMOX2 Heme oxygenase 2
8797


Q86UP2_C1105
KTN1 Kinectin
8798


O15042_C624
U2SURP U2 snRNP-
8799



associated SURP motif-



containing protein


Q9NVZ3_C133
NECAP2 Adaptin ear-binding
8800



coat-associated protein 2


P26651_C253
ZFP36 Tristetraprolin
8801


Q5TFE4_C119
NT5DC1 5-nucleotidase
8802



domain-containing protein 1


Q9BRP1_C278
PDCD2L Programmed cell
8803



death protein 2-like


Q9H410_C287
DSN1 Kinetochore-associated
8804



protein DSN1 homolog


P27986_C146
PIK3R1 Phosphatidylinositol
8805



3-kinase regulatory subunit



alpha


P10144_C142
GZMB Granzyme B
8806


Q9UKF6_C498
CPSF3 Cleavage and
8807



polyadenylation specificity



factor subunit


P55265_C1224
ADAR Double-stranded RNA-
8808



specific adenosine deaminase


Q9NXV6_C516
CDKN2AIP CDKN2A-
8809



interacting protein


Q7Z401_C1289
DENND4A C-myc promoter-
8810



binding protein


Q9NVT9_C69
ARMC1 Armadillo repeat-
8811



containing protein 1


Q9GZR7_C832
DDX24 ATP-dependent RNA
8812



helicase DDX24


Q2TAA2_C137
IAH1 Isoamyl acetate-
8813



hydrolyzing esterase 1



homolog


Q2TAA2_C150
IAH1 Isoamyl acetate-
8814



hydrolyzing esterase 1



homolog


Q2TAA2_C145
IAH1 Isoamyl acetate-
8815



hydrolyzing esterase 1



homolog


Q13315_C384
ATM Serine-protein kinase
8816



ATM


Q9BXJ9_C721
NAA15 N-alpha-
8817



acetyltransferase 15, NatA



auxiliary subunit


Q8TD19_C623
NEK9 Serine/threonine-
8818



protein kinase Nek9


P50749_C251
RASSF2 Ras association
8819



domain-containing protein 2


Q92831_C690
KAT2B Histone
8820



acetyltransferase KAT2B


Q92830_C695
KAT2A Histone
8821



acetyltransferase KAT2A


P11216_C437
PYGB Glycogen
8822



phosphorylase, brain form


P30044_C100
PRDX5 Peroxiredoxin-5,
8823



mitochondrial


Q9Y3T9_C585
NOC2L Nucleolar complex
8824



protein 2 homolog


Q9NVG8_C387
TBC1D13 TBC1 domain
8825



family member 13


O14933_C102
UBE2L6 Ubiquitin/ISG15-
8826



conjugating enzyme E2 L6


Q9UNE7_C199
STUB1 E3 ubiquitin-protein
8827



ligase CHIP


Q9UKA4_C1257
AKAP11 A-kinase anchor
8828



protein 11


Q8TCU6_C37
PREX1 Phosphatidylinositol
8829



3,4,5-trisphosphate-dependent


P54274_C118
TERF1 Telomeric repeat-
8830



binding factor 1


P11161_C469
EGR2 E3 SUMO-protein
8831



ligase EGR2


P11161_C454
EGR2 E3 SUMO-protein
8832



ligase EGR2


Q8TAQ2_C145
SMARCC2 SWI/SNF
8833



complex subunit SMARCC2


Q13232_C158
NME3 Nucleoside
8834



diphosphate kinase 3


Q9NXV6_C178
CDKN2AIP CDKN2A-
8835



interacting protein


P01106_C25
MYC Myc proto-oncogene
8836



protein


Q6L8Q7_C108
PDE12 2,5-phosphodiesterase
8837



12


Q6L8Q7_C119
PDE12 2,5-phosphodiesterase
8838



12


P45880_C210
VDAC2 Voltage-dependent
8839



anion-selective channel protein


B0V043_C41
VARS Valyl-tRNA synthetase
8840


P45880_C227
VDAC2 Voltage-dependent
8841



anion-selective channel protein


Q9BU23_C696
LMF2 Lipase maturation
8842



factor 2


Q8NDX1_C435
PSD4 PH and SEC7 domain-
8843



containing protein 4


Q9Y4B6_C784
VPRBP Protein VPRBP
8844


Q8IY21_C1051
DDX60 Probable ATP-
8845



dependent RNA helicase



DDX60


O94829_C217
IPO13 Importin-13
8846


Q92835_C1088
INPP5D Phosphatidylinositol
8847



3,4,5-trisphosphate 5-



phosphatase


P01106_C70
MYC Myc proto-oncogene
8848



protein


Q99829_C53
CPNE1 Copine-1
8849


Q9Y2S2_C125
CRYL1 Lambda-crystallin
8850



homolog


Q14289_C562
PTK2B Protein-tyrosine
8851



kinase 2-beta


P41240_C290
CSK Tyrosine-protein kinase
8852



CSK


Q01826_C529
SATB1 DNA-binding protein
8853



SATB1


Q9UPW6_C518
SATB2 DNA-binding protein
8854



SATB2


Q9GZT9_C127
EGLN1 Egl nine homolog 1
8855


Q99590_C553
SCAF11 Protein SCAF11
8856


Q13077_C37
TRAF1 TNF receptor-
8857



associated factor 1


Q13077_C38
TRAF1 TNF receptor-
8858



associated factor 1


O95352_C524
ATG7 Ubiquitin-like modifier-
8859



activating enzyme ATG7


Q63HN8_C62
RNF213 E3 ubiquitin-protein
8860



ligase RNF213


Q63HN8_C78
RNF213 E3 ubiquitin-protein
8861



ligase RNF213


E9PPU0_C1888
EPPK1 Epiplakin
8862


Q63HN8_C4258
RNF213 E3 ubiquitin-protein
8863



ligase RNF213


Q9UKX7_C151
NUP50 Nuclear pore complex
8864



protein Nup50


P45880_C76
VDAC2 Voltage-dependent
8865



anion-selective channel protein


Q6NYC8_C397
PPP1R18 Phostensin
8866


Q6NYC8_C396
PPP1R18 Phostensin
8867


Q9ULV4_C420
CORO1C Coronin-1C
8868


Q96I15_C22
SCLY Selenocysteine lyase
8869


Q8WXH0_C553
SYNE2 Nesprin-2
8870


Q9Y277_C36
VDAC3 Voltage-dependent
8871



anion-selective channel protein


P31153_C104
MAT2A S-
8872



adenosylmethionine synthase



isoform type-2


Q14005_C1004
IL16 Pro-interleukin-16
8873


Q16548_C19
BCL2A1 Bcl-2-related protein
8874



A1


P18583_C92
SON Protein SON
8875


P31153_C56
MAT2A S-
8876



adenosylmethionine synthase



isoform type-2


Q04759_C14
PRKCQ Protein kinase C theta
8877



type


Q7Z4W1_C244
DCXR L-xylulose reductase
8878


Q9Y6C9_C296
MTCH2 Mitochondrial carrier
8879



homolog 2


Q86YS7_C993
KIAA0528 Uncharacterized
8880



protein KIAA0528


Q13045_C46
FLII Protein flightless-1
8881



homolog


Q9UL40_C68
ZNF346 Zinc finger protein
8882



346


Q5T4S7_C2554
UBR4 E3 ubiquitin-protein
8883



ligase UBR4


Q8N0Z8_C292
PUSL1 tRNA pseudouridine
8884



synthase-like 1


P46109_C249
CRKL Crk-like protein
8885


Q96CW5_C194
TUBGCP3 Gamma-tubulin
8886



complex component 3


P54136_C32
RARS Arginine--tRNA ligase,
8887



cytoplasmic


Q15005_C17
SPCS2 Signal peptidase
8888



complex subunit 2


Q15306_C194
IRF4 Interferon regulatory
8889



factor 4


Q96GW9_C425
MARS2 Methionine--tRNA
8890



ligase, mitochondrial


Q02556_C306
IRF8 Interferon regulatory
8891



factor 8


Q9Y4W2_C456
LAS1L Ribosomal biogenesis
8892



protein LAS1L


Q8TB24_C942
RIN3 Ras and Rab interactor 3
8893


Q96Q11_C373
TRNT1 CCA tRNA
8894



nucleotidyltransferase 1,



mitochondrial


O00170_C122
AIP AH receptor-interacting
8895



protein


Q7Z2W4_C645
ZC3HAV1 Zinc finger CCCH-
8896



type antiviral protein 1


O95081_C39
AGFG2 Arf-GAP domain and
8897



FG repeat-containing protein 2


P11216_C326
PYGB Glycogen
8898



phosphorylase, brain form


Q16548_C55
BCL2A1 Bcl-2-related protein
8899



A1


Q7Z6Z7_C3372
HUWE1 E3 ubiquitin-protein
8900



ligase HUWE1


A6NDG6_C297
PGP Phosphoglycolate
8901



phosphatase


O95336_C32
PGLS 6-
8902



phosphogluconolactonase


O14933_C98
UBE2L6 Ubiquitin/ISG15-
8903



conjugating enzyme E2 L6


P49588_C773
AARS Alanine--tRNA ligase,
8904



cytoplasmic


Q9Y277_C65
VDAC3 Voltage-dependent
8905



anion-selective channel protein


Q6IA69_C428
NADSYN1 Glutamine-
8906



dependent NAD(+) synthetase


Q9Y2W6_C109
TDRKH Tudor and KH
8907



domain-containing protein


Q9NRW3_C130
APOBEC3C Probable DNA
8908



dC- dU-editing enzyme



APOBEC-3C


P00813_C75
ADA Adenosine deaminase
8909


O14920_C464
IKBKB Inhibitor of nuclear
8910



factor kappa-B kinase subunit


Q9NWZ3_C13
IRAK4 Interleukin-1 receptor-
8911



associated kinase 4


Q13422_C394
IKZF1 DNA-binding protein
8912



Ikaros


Q04759_C17
PRKCQ Protein kinase C theta
8913



type


Q14005_C1011
IL16 Pro-interleukin-16
8914


O75694_C1344
NUP155 Nuclear pore
8915



complex protein Nup155


Q9BU76_C58
MMTAG2 Multiple myeloma
8916



tumor-associated protein 2


Q6FI81_C251
CIAPIN1 Anamorsin
8917


P54136_C34
RARS Arginine--tRNA ligase,
8918



cytoplasmic


Q3ZCM7_C303
TUBB8 Tubulin beta-8 chain
8919


Q3ZCM7_C354
TUBB8 Tubulin beta-8 chain
8920


Q13163_C300
MAP2K5 Dual specificity
8921



mitogen-activated protein



kinase


Q8IZL8_C237
PELP1 Proline-, glutamic
8922



acid- and leucine-rich protein


A0AVT1_C546
UBA6 Ubiquitin-like
8923



modifier-activating enzyme 6


Q7L2J0_C522
MEPCE 7SK snRNA
8924



methylphosphate capping



enzyme


Q14657_C23
LAGE3 L antigen family
8925



member 3


B0I1T2_C979
MYO1G Unconventional
8926



myosin-Ig


P36969_C134
GPX4 Phospholipid
8927



hydroperoxide glutathione



peroxidase, mitochondrial


Q14149_C15
MORC3 MORC family CW-
8928



type zinc finger protein 3


P82932_C105
MRPS6 28S ribosomal protein
8929



S6, mitochondrial


Q16666_C637
IFI16 Gamma-interferon-
8930



inducible protein 16


Q10567_C866
AP1B1 AP-1 complex subunit
8931



beta-1


Q709C8_C2159
VPS13C Vacuolar protein
8932



sorting-associated protein 13C


Q7Z6Z7_C3375
HUWE1 E3 ubiquitin-protein
8933



ligase HUWE1


Q7Z6Z7_C3385
HUWE1 E3 ubiquitin-protein
8934



ligase HUWE1


Q9ULA0_C327
DNPEP Aspartyl
8935



aminopeptidase


P29590_C479
PML Protein PML
8936


Q9NRG0_C55
CHRAC1 Chromatin
8937



accessibility complex protein 1


Q14005_C1016
IL16 Pro-interleukin-16
8938


Q8NCF5_C232
NFATC2IP NFATC2-
8939



interacting protein


Q96QT6_C233
PHF12 PHD finger protein 12
8940


Q29RF7_C532
PDS5A Sister chromatid
8941



cohesion protein PDS5



homolog A


Q16254_C88
E2F4 Transcription factor
8942



E2F4


Q53GL7_C434
PARP10 Poly
8943


Q93009_C315
USP7 Ubiquitin carboxyl-
8944



terminal hydrolase 7


O95931_C102
CBX7 Chromobox protein
8945



homolog 7


O95931_C107
CBX7 Chromobox protein
8946



homolog 7


Q5VZ89_C850
DENND4C DENN domain-
8947



containing protein 4C


Q8NF50_C939
DOCK8 Dedicator of
8948



cytokinesis protein 8


Q7Z3B4_C171
NUP54 Nucleoporin p54
8949


Q6FI81_C249
CIAPIN1 Anamorsin
8950


Q92888_C595
ARHGEF1 Rho guanine
8951



nucleotide exchange factor 1


Q8TDG2_C182
ACTRT1 Actin-related protein
8952



T1


O60216_C78
RAD21 Double-strand-break
8953



repair protein rad21 homolog


Q9UPN6_C102
SCAF8 Protein SCAF8
8954


Q9NVC6_C649
MED17 Mediator of RNA
8955



polymerase II transcription



subunit 17


P35579_C816
MYH9 Myosin-9
8956


Q9P0J1_C149
PDP1
8957


O95602_C613
POLR1A DNA-directed RNA
8958



polymerase I subunit RPA1


Q8IZL8_C536
PELP1 Proline-, glutamic
8959



acid- and leucine-rich protein


P42331_C154
ARHGAP25 Rho GTPase-
8960



activating protein 25


P78527_C3837
PRKDC DNA-dependent
8961



protein kinase catalytic subunit


P61978_C185
HNRNPK Heterogeneous
8962



nuclear ribonucleoprotein K


P51610_C352
HCFC1 Host cell factor 1
8963


J3QR44_C422
CDK11B Cyclin-dependent
8964



kinase 11B


P21127_C432
CDK11B Cyclin-dependent
8965



kinase 11B


Q01082_C183
SPTBN1 Spectrin beta chain,
8966



non-erythrocytic 1


P05771_C502
PRKCB Protein kinase C beta
8967



type


Q9NYQ6_C1840
CELSR1 Cadherin EGF LAG
8968



seven-pass G-type receptor 1


Q8NBU5_C137
ATAD1 ATPase family AAA
8969



domain-containing protein 1


Q9BXL7_C539
CARD11 Caspase recruitment
8970



domain-containing protein 11


Q6PCE3_C303
PGM2L1 Glucose 1,6-
8971



bisphosphate synthase


Q9BTE3_C287
MCMBP Mini-chromosome
8972



maintenance complex-binding



protein


Q9NTM9_C248
CUTC Copper homeostasis
8973



protein cutC homolog


Q9Y4P1_C74
ATG4B Cysteine protease
8974



ATG4B


P21580_C657
TNFAIP3 Tumor necrosis
8975



factor alpha-induced protein 3


O43149_C2546
ZZEF1 Zinc finger ZZ-type
8976



and EF-hand domain-



containing 1


Q8NHV1_C195
GIMAP7 GTPase IMAP
8977



family member 7


Q14644_C206
RASA3 Ras GTPase-
8978



activating protein 3


Q99567_C608
NUP88 Nuclear pore complex
8979



protein Nup88


P08311_C142
CTSG Cathepsin G
8980


O60256_C31
PRPSAP2 Phosphoribosyl
8981



pyrophosphate synthase-



associated protein 2


O95785_C1429
WIZ Protein Wiz
8982


O00148_C74
DDX39A ATP-dependent
8983



RNA helicase DDX39A


O00148_C86
DDX39A ATP-dependent
8984



RNA helicase DDX39A


Q9H4E7_C266
DEF6 Differentially expressed
8985



in FDCP 6 homolog


P31949_C91
S100A11 Protein S100-A11
8986


P18206_C85
VCL Vinculin
8987


P12931_C280
SRC Proto-oncogene tyrosine-
8988



protein kinase Src


Q9UK61_C830
FAM208A Protein FAM208A
8989


P19838_C925
NFKB1 Nuclear factor NF-
8990



kappa-B p105 subunit


Q15418_C432
RPS6KA1 Ribosomal protein
8991



S6 kinase alpha-1


P17987_C397
TCP1 T-complex protein 1
8992



subunit alpha


P30566_C483
ADSL Adenylosuccinate lyase
8993


Q96FV9_C49
THOC1 THO complex subunit
8994



1


Q9H9Y6_C1061
POLR1B DNA-directed RNA
8995



polymerase I subunit RPA2


Q9UN37_C403
VPS4A Vacuolar protein
8996



sorting-associated protein 4A


Q49A26_C303
GLYR1 Putative
8997



oxidoreductase GLYR1


P49591_C300
SARS Serine--tRNA ligase,
8998



cytoplasmic


P78371_C289
CCT2 T-complex protein 1
8999



subunit beta


P55786_C265
NPEPPS Puromycin-sensitive
9000



aminopeptidase


Q9Y314_C185
NOSIP Nitric oxide synthase-
9001



interacting protein


P30466_C188
HLA-B HLA class I histocompatibility
9002



antigen, B-18 alpha


P30462_C188
HLA-B HLA class I histocompatibility
9003



antigen, B-14 alpha


Q14980_C80
NUMA1 Nuclear mitotic
9004



apparatus protein 1


P36954_C52
POLR2I DNA-directed RNA
9005



polymerase II subunit RPB9


O95639_C41
CPSF4 Cleavage and
9006



polyadenylation specificity



factor subunit


P14618_C49
PKM Pyruvate kinase
9007



isozymes M1/M2


Q7L4I2_C382
RSRC2 Arginine/serine-rich
9008



coiled-coil protein 2


A6NHR9_C1899
SMCHD1 Structural
9009



maintenance of chromosomes



flexible hinge domain



containing 1


Q86U90_C99
YRDC YrdC domain-
9010



containing protein,



mitochondrial


Q86U90_C95
YRDC YrdC domain-
9011



containing protein,



mitochondrial


Q14839_C1827
CHD4 Chromodomain-
9012



helicase-DNA-binding protein



4


Q92499_C111
DDX1 ATP-dependent RNA
9013



helicase DDX1


P49411_C222
TUFM Elongation factor Tu,
9014



mitochondrial


P49411_C290
TUFM Elongation factor Tu,
9015



mitochondrial


Q9Y5U2_C99
TSSC4 Protein TSSC4
9016


P49189_C267
ALDH9A1 4-
9017



trimethylaminobutyraldehyde



dehydrogenase


O75376_C1274
NCOR1 Nuclear receptor
9018



corepressor 1


P23743_C645
DGKA Diacylglycerol kinase
9019



alpha


P26368_C429
U2AF2 Splicing factor U2AF
9020



65 kDa subunit


Q01432_C47
AMPD3 AMP deaminase 3
9021


Q9HBH5_C97
RDH14 Retinol
9022



dehydrogenase 14


Q13576_C276
IQGAP2 Ras GTPase-
9023



activating-like protein



IQGAP2


Q9H5V9_C11
CXorf56 UPF0428 protein
9024



CXorf56


Q9NYK5_C335
MRPL39 39S ribosomal
9025



protein L39, mitochondrial


Q96JM7_C233
L3MBTL3 Lethal(3)malignant
9026



brain tumor-like protein 3


P20591_C42
MX1 Interferon-induced GTP-
9027



binding protein Mx1


Q9NVS2_C186
MRPS18A 28S ribosomal
9028



protein S18a, mitochondrial


O15042_C65
U2SURP U2 snRNP-
9029



associated SURP motif-



containing protein


Q5H9U9_C1031
DDX60L Probable ATP-
9030



dependent RNA helicase



DDX60-like


Q9Y4A5_C3535
TRRAP
9031



Transformation/transcription



domain-associated protein


O60313_C801
OPA1 Dynamin-like 120 kDa
9032



protein, mitochondrial


O60759_C246
CYTIP Cytohesin-interacting
9033



protein


P51531_C1296
SMARCA2 Probable global
9034



transcription activator SNF2L2


P51532_C1359
SMARCA4 Transcription
9035



activator BRG1


Q6QNY0_C168
BLOC1S3 Biogenesis of
9036



lysosome-related organelles



complex


P16615_C447
ATP2A2
9037



Sarcoplasmic/endoplasmic



reticulum calcium ATPase


Q6PJI9_C654
WDR59 WD repeat-containing
9038



protein 59


Q99683_C928
MAP3K5 Mitogen-activated
9039



protein kinase kinase kinase 5


Q99714_C58
HSD17B10 3-hydroxyacyl-
9040



CoA dehydrogenase type-2


A6NC98_C1222
CCDC88B Coiled-coil
9041



domain-containing protein



88B


P78527_C4045
PRKDC DNA-dependent
9042



protein kinase catalytic subunit


Q9C0B1_C171
FTO Alpha-ketoglutarate-
9043



dependent dioxygenase FTO


Q9Y490_C2161
TLN1 Talin-1
9044


P78527_C3403
PRKDC DNA-dependent
9045



protein kinase catalytic subunit


Q9H668_C8
OBFC1 CST complex subunit
9046



STN1


Q96FS4_C811
SIPA1 Signal-induced
9047



proliferation-associated



protein 1


Q8NI27_C1064
THOC2 THO complex subunit
9048



2


O15213_C515
WDR46 WD repeat-containing
9049



protein 46


P48147_C255
PREP Prolyl endopeptidase
9050


B5ME19_C753
EIF3CL Eukaryotic translation
9051



initiation factor 3 subunit


Q15118_C71
PDK1
9052


P12081_C509
HARS Histidine--tRNA ligase,
9053



cytoplasmic


O60684_C253
KPNA6 Importin subunit
9054



alpha-7


Q9BVP2_C234
GNL3 Guanine nucleotide-
9055



binding protein-like 3


P09326_C148
CD48 CD48 antigen
9056


O75663_C14
TIPRL TIP41-like protein
9057


Q9Y4W2_C306
LAS1L Ribosomal biogenesis
9058



protein LAS1L


Q92889_C560
ERCC4 DNA repair
9059



endonuclease XPF


Q9Y4F9_C519
FAM65B Protein FAM65B
9060


Q8N8A6_C402
DDX51 ATP-dependent RNA
9061



helicase DDX51


Q92900_C188
UPF1 Regulator of nonsense
9062



transcripts 1


Q27J81_C971
INF2 Inverted formin-2
9063


O00422_C26
SAP18 Histone deacetylase
9064



complex subunit SAP18


Q9BRU9_C207
UTP23 rRNA-processing
9065



protein UTP23 homolog


Q9NV88_C578
INTS9 Integrator complex
9066



subunit 9


P57740_C78
NUP107 Nuclear pore
9067



complex protein Nup107


Q15005_C26
SPCS2 Signal peptidase
9068



complex subunit 2


O75643_C238
SNRNP200 U5 small nuclear
9069



ribonucleoprotein 200 kDa



helicase


Q92608_C41
DOCK2 Dedicator of
9070



cytokinesis protein 2


P62913_C72
RPL11 60S ribosomal protein
9071



L11


Q96FS4_C755
SIPA1 Signal-induced
9072



proliferation-associated



protein 1


Q92974_C306
ARHGEF2 Rho guanine
9073



nucleotide exchange factor 2


Q8TDB6_C175
DTX3L E3 ubiquitin-protein
9074



ligase DTX3L


Q68EM7_C305
ARHGAP17 Rho GTPase-
9075



activating protein 17


O75131_C54
CPNE3 Copine-3
9076


Q9P107_C895
GMIP GEM-interacting
9077



protein


Q8IYQ7_C324
THNSL1 Threonine synthase-
9078



like 1


Q05086_C83
UBE3A Ubiquitin-protein
9079



ligase E3A


Q8IWZ3_C181
ANKHD1 Ankyrin repeat and
9080



KH domain-containing protein



1


Q14671_C1179
PUM1 Pumilio homolog 1
9081


Q9BVL2_C252
NUPL1 Nucleoporin p58/p45
9082


Q8NF50_C186
DOCK8 Dedicator of
9083



cytokinesis protein 8


Q9HB21_C389
PLEKHA1 Pleckstrin
9084



homology domain-containing



family A member 1


Q96HC4_C213
PDLIM5 PDZ and LIM
9085



domain protein 5


Q9UPU5_C1362
USP24 Ubiquitin carboxyl-
9086



terminal hydrolase 24


Q9Y5T5_C618
USP16 Ubiquitin carboxyl-
9087



terminal hydrolase 16


Q9Y570_C381
PPME1 Protein phosphatase
9088



methylesterase 1


Q9NYK5_C133
MRPL39 39S ribosomal
9089



protein L39, mitochondrial


Q96T51_C703
RUFY1 RUN and FYVE
9090



domain-containing protein 1


Q16643_C613
DBN1 Drebrin
9091


Q9Y5B0_C429
CTDP1 RNA polymerase II
9092



subunit A C-terminal domain



phosphatase


Q8N806_C260
UBR7 Putative E3 ubiquitin-
9093



protein ligase UBR7


Q96K76_C856
USP47 Ubiquitin carboxyl-
9094



terminal hydrolase 47


Q9UDY8_C71
MALT1 Mucosa-associated
9095



lymphoid tissue lymphoma



translocation protein 1


Q8IY81_C577
FTSJ3 pre-rRNA processing
9096



protein FTSJ3


P21333_C796
FLNA Filamin-A
9097


P11413_C446
G6PD Glucose-6-phosphate 1-
9098



dehydrogenase


P42575_C320
CASP2 Caspase-2
9099


Q04760_C61
GLO1 Lactoylglutathione
9100



lyase


O00562_C259
PITPNM1 Membrane-
9101



associated



phosphatidylinositol transfer


P49848_C141
TAF6 Transcription initiation
9102



factor TFIID subunit 6


P08567_C160
PLEK Pleckstrin
9103


Q7Z7H8_C180
MRPL10 39S ribosomal
9104



protein L10, mitochondrial


O95786_C268
DDX58 Probable ATP-
9105



dependent RNA helicase



DDX58


P17655_C105
CAPN2 Calpain-2 catalytic
9106



subunit


O00541_C361
PES1 Pescadillo homolog
9107


Q8WVV9_C405
HNRPLL Heterogeneous
9108



nuclear ribonucleoprotein L-



like


P45974_C335
USP5 Ubiquitin carboxyl-
9109



terminal hydrolase 5


P14868_C203
DARS Aspartate--tRNA
9110



ligase, cytoplasmic


Q8WWY3_C247
PRPF31 U4/U6 small nuclear
9111



ribonucleoprotein Prp31


Q9P258_C280
RCC2 Protein RCC2
9112


P22087_C99
FBL rRNA 2-O-
9113



methyltransferase fibrillarin


Q8N8A2_C408
ANKRD44 Serine/threonine-
9114



protein phosphatase 6



regulatory


Q96EB1_C361
ELP4 Elongator complex
9115



protein 4


P20073_C413
ANXA7 Annexin A7
9116


Q6PGP7_C1162
TTC37 Tetratricopeptide
9117



repeat protein 37


Q9Y490_C1978
TLN1 Talin-1
9118


Q14204_C1888
DYNC1H1 Cytoplasmic
9119



dynein 1 heavy chain 1


Q8N8A2_C334
ANKRD44 Serine/threonine-
9120



protein phosphatase 6



regulatory


Q96EY4_C162
TMA16 Translation
9121



machinery-associated protein



16


Q9UJX4_C203
ANAPC5 Anaphase-
9122



promoting complex subunit 5


Q9Y490_C1509
TLN1 Talin-1
9123


P07814_C1480
EPRS Bifunctional
9124



glutamate/proline--tRNA



ligase


Q14152_C198
EIF3A Eukaryotic translation
9125



initiation factor 3 subunit


P52306_C29
RAP1GDS1 Rap1 GTPase-
9126



GDP dissociation stimulator 1


Q96RL1_C257
UIMC1 BRCA1-A complex
9127



subunit RAP80


Q8N4N3_C254
KLHL36 Kelch-like protein 36
9128


Q92616_C55
GCN1L1 Translational
9129



activator GCN1


Q14966_C652
ZNF638 Zinc finger protein
9130



638


P40763_C687
STAT3 Signal transducer and
9131



activator of transcription 3


P22307_C94
SCP2 Non-specific lipid-
9132



transfer protein


P41250_C466
GARS Glycine--tRNA ligase
9133


Q8WXH0_C5315
SYNE2 Nesprin-2
9134


P13639_C567
EEF2 Elongation factor 2
9135


Q99973_C171
TEP1 Telomerase protein
9136



component 1


Q8N4C6_C1986
NIN Ninein
9137


Q8TBC4_C237
UBA3 NEDD8-activating
9138



enzyme E1 catalytic subunit


Q5VWQ0_C318
RSBN1 Round spermatid
9139



basic protein 1


Q96FS4_C732
SIPA1 Signal-induced
9140



proliferation-associated



protein 1


P20700_C198
LMNB1 Lamin-B1
9141


P34949_C289
MPI Mannose-6-phosphate
9142



isomerase


Q5T1M5_C828
FKBP15 FK506-binding
9143



protein 15


Q13315_C2991
ATM Serine-protein kinase
9144



ATM


Q9UIG0_C953
BAZ1B Tyrosine-protein
9145



kinase BAZ1B


Q9ULX6_C128
AKAP8L A-kinase anchor
9146



protein 8-like


Q92620_C865
DHX38 Pre-mRNA-splicing
9147



factor ATP-dependent RNA



helicas


Q7L5D6_C160
GET4 Golgi to ER traffic
9148



protein 4 homolog


P34932_C417
HSPA4 Heat shock 70 kDa
9149



protein 4


Q7KZ85_C1435
SUPT6H Transcription
9150



elongation factor SPT6


Q9Y2Z2_C315
MTO1 Protein MTO1
9151



homolog, mitochondrial


P08514_C87
ITGA2B Integrin alpha-IIb
9152


O75821_C139
EIF3G Eukaryotic translation
9153



initiation factor 3 subunit


Q9Y265_C141
RUVBL1 RuvB-like 1
9154


Q969M7_C50
UBE2F NEDD8-conjugating
9155



enzyme UBE2F


H3BSR4_C50
UBE2F Ubiquitin-conjugating
9156



enzyme E2F (Putative)


P25098_C120
ADRBK1 Beta-adrenergic
9157



receptor kinase 1


O60831_C28
PRAF2 PRA1 family protein 2
9158


O00429_C367
DNM1L Dynamin-1-like
9159



protein


Q7Z5K2_C160
WAPAL Wings apart-like
9160



protein homolog


P13807_C699
GYS1 Glycogen
9161


Q96CP2_C132
FLYWCH2 FLYWCH family
9162



member 2


P26651_C250
ZFP36 Tristetraprolin
9163


Q92974_C478
ARHGEF2 Rho guanine
9164



nucleotide exchange factor 2


Q9H4B7_C303
TUBB1 Tubulin beta-1 chain
9165


Q9Y5A7_C52
NUB1 NEDD8 ultimate buster
9166



1


Q8IZD4_C369
DCP1B mRNA-decapping
9167



enzyme 1B


Q13422_C223
IKZF1 DNA-binding protein
9168



Ikaros


Q15181_C270
PPA1 Inorganic
9169



pyrophosphatase


P49916_C929
LIG3 DNA ligase 3
9170


Q9Y6C9_C49
MTCH2 Mitochondrial carrier
9171



homolog 2


O15265_C639
ATXN7 Ataxin-7
9172


Q9BQ67_C11
GRWD1 Glutamate-rich WD
9173



repeat-containing protein 1


Q7Z6Z7_C3658
HUWE1 E3 ubiquitin-protein
9174



ligase HUWE1


Q9BTE3_C325
MCMBP Mini-chromosome
9175



maintenance complex-binding



protein


Q92917_C137
GPKOW G patch domain and
9176



KOW motifs-containing



protein


Q9BSA9_C32
TMEM175 Transmembrane
9177



protein 175


Q9H9A5_C504
CNOT10 CCR4-NOT
9178



transcription complex subunit



10


P0CB43_C51
FAM203B Protein FAM203B
9179


Q9BWU0_C125
SLC4A1AP Kanadaptin
9180


Q96FW1_C91
OTUB1 Ubiquitin thioesterase
9181



OTUB1


Q9UEY8_C73
ADD3 Gamma-adducin
9182


Q8N4N3_C308
KLHL36 Kelch-like protein 36
9183


Q9H3M7_C170
TXNIP Thioredoxin-
9184



interacting protein


Q8N9N7_C128
LRRC57 Leucine-rich repeat-
9185



containing protein 57


I3L1I5_C144
Uncharacterized protein
9186


Q7L2J0_C54
MEPCE 7SK snRNA
9187



methylphosphate capping



enzyme


Q9Y2H0_C800
DLGAP4 Disks large-
9188



associated protein 4


Q9Y314_C8
NOSIP Nitric oxide synthase-
9189



interacting protein


Q9Y490_C1927
TLN1 Talin-1
9190


Q8N2G8_C502
GHDC GH3 domain-
9191



containing protein


P53992_C78
SEC24C Protein transport
9192



protein Sec24C


P60891_C91
PRPS1 Ribose-phosphate
9193



pyrophosphokinase 1


P11908_C91
PRPS2 Ribose-phosphate
9194



pyrophosphokinase 2


P21108_C91
PRPS1L1 Ribose-phosphate
9195



pyrophosphokinase 3


Q9UPN7_C216
PPP6R1 Serine/threonine-
9196



protein phosphatase 6



regulatory


Q63HN8_C3084
RNF213 E3 ubiquitin-protein
9197



ligase RNF213


P61247_C111
RPS3A 40S ribosomal protein
9198



S3a


P18583_C2070
SON Protein SON
9199


P28331_C727
NDUFS1 NADH-ubiquinone
9200



oxidoreductase 75 kDa



subunit, mitochondrial


P46063_C478
RECQL ATP-dependent DNA
9201



helicase Q1


Q7L2J0_C429
MEPCE 7SK snRNA
9202



methylphosphate capping



enzyme


Q9NR45_C287
NANS Sialic acid synthase
9203


Q92945_C379
KHSRP Far upstream element-
9204



binding protein 2


O75934_C132
BCAS2 Pre-mRNA-splicing
9205



factor SPF27


P42229_C101
STAT5A Signal transducer
9206



and activator of transcription 5


Q96SI9_C195
STRBP Spermatid perinuclear
9207



RNA-binding protein


P78527_C1629
PRKDC DNA-dependent
9208



protein kinase catalytic subunit


P28715_C12
ERCC5 DNA repair protein
9209



complementing XP-G cells


O60318_C1839
MCM3AP 80 kDa MCM3-
9210



associated protein


P43354_C190
NR4A2 Nuclear receptor
9211



subfamily 4 group A member



2


Q562E7_C215
WDR81 WD repeat-containing
9212



protein 81


P61247_C139
RPS3A 40S ribosomal protein
9213



S3a


P19174_C646
PLCG1 1-phosphatidylinositol
9214



4,5-bisphosphate



phosphodiesterase


Q8IUR7_C283
ARMC8 Armadillo repeat-
9215



containing protein 8


O75828_C227
CBR3 Carbonyl reductase
9216


Q9NR30_C291
DDX21 Nucleolar RNA
9217



helicase 2


Q9HCK8_C1655
CHD8 Chromodomain-
9218



helicase-DNA-binding protein



8


Q5T4S7_C3864
UBR4 E3 ubiquitin-protein
9219



ligase UBR4


Q9H869_C290
YY1AP1 YY1-associated
9220



protein 1


Q3T8J9_C813
GON4L GON-4-like protein
9221


P11161_C234
EGR2 E3 SUMO-protein
9222



ligase EGR2


P50579_C436
METAP2 Methionine
9223



aminopeptidase 2


P42229_C126
STAT5A Signal transducer
9224



and activator of transcription 5


Q15545_C72
TAF7 Transcription initiation
9225



factor TFIID subunit 7


Q9UM19_C187
HPCAL4 Hippocalcin-like
9226



protein 4


Q92989_C338
CLP1 Polyribonucleotide 5-
9227



hydroxyl-kinase Clp1


Q5VV42_C138
CDKAL1
9228



Threonylcarbamoyladenosine



tRNA methylthiotransferase


Q9BVQ7_C580
SPATA5L1 Spermatogenesis-
9229



associated protein 5-like



protein


P24928_C451
POLR2A DNA-directed RNA
9230



polymerase II subunit RPB1


Q14573_C2668
ITPR3 Inositol 1,4,5-
9231



trisphosphate receptor type 3


Q9NUU7_C392
DDX19A ATP-dependent
9232



RNA helicase DDX19A


Q9UMR2_C393
DDX19B ATP-dependent
9233



RNA helicase DDX19B


P49368_C398
CCT3 T-complex protein 1
9234



subunit gamma


P0DJD1_C348
RGPD2 RANBP2-like and
9235



GRIP domain-containing



protein 2


Q8TF42_C367
UBASH3B Ubiquitin-
9236



associated and SH3 domain-



containing protein


Q9BWG4_C81
SSBP4 Single-stranded DNA-
9237



binding protein 4


P50995_C501
ANXA11 Annexin A11
9238


Q9UPP1_C684
PHF8 Histone lysine
9239



demethylase PHF8


Q9UQ35_C1036
SRRM2 Serine/arginine
9240



repetitive matrix protein 2


Q9Y6A5_C749
TACC3 Transforming acidic
9241



coiled-coil-containing protein


P13489_C248
RNH1 Ribonuclease inhibitor
9242


Q66K74_C588
MAP1S Microtubule-
9243



associated protein 1S


Q16881_C209
TXNRD1 Thioredoxin
9244



reductase 1, cytoplasmic


H0YBQ0_C258
TXNRD3 Thioredoxin
9245



reductase 3


Q9NNW7_C86
TXNRD2 Thioredoxin
9246



reductase 2, mitochondrial


P78527_C1499
PRKDC DNA-dependent
9247



protein kinase catalytic subunit


Q9UGR2_C956
ZC3H7B Zinc finger CCCH
9248



domain-containing protein 7B


P49903_C71
SEPHS1 Selenide, water
9249



dikinase 1


O14976_C87
GAK Cyclin-G-associated
9250



kinase


Q86WB0_C406
ZC3HC1 Nuclear-interacting
9251



partner of ALK


Q9H9A6_C23
LRRC40 Leucine-rich repeat-
9252



containing protein 40


Q3KQU3_C373
MAP7D1 MAP7 domain-
9253



containing protein 1


Q9H4L5_C24
OSBPL3 Oxysterol-binding
9254



protein-related protein 3


P27987_C561
ITPKB Inositol-trisphosphate
9255



3-kinase B


Q9Y520_C177
PRRC2C Protein PRRC2C
9256


P53041_C77
PPP5C Serine/threonine-
9257



protein phosphatase 5


Q9Y2H0_C726
DLGAP4 Disks large-
9258



associated protein 4


P21580_C54
TNFAIP3 Tumor necrosis
9259



factor alpha-induced protein 3


Q15334_C505
LLGL1 Lethal(2) giant larvae
9260



protein homolog 1


O15111_C406
CHUK Inhibitor of nuclear
9261



factor kappa-B kinase subunit


Q14149_C797
MORC3 MORC family CW-
9262



type zinc finger protein 3


O00329_C219
PIK3CD Phosphatidylinositol
9263



4,5-bisphosphate 3-kinase



catalytic subunit delta isoform


Q9NPD3_C97
EXOSC4 Exosome complex
9264



component RRP41


P98171_C527
ARHGAP4 Rho GTPase-
9265



activating protein 4


Q8NFI3_C454
ENGASE Cytosolic endo-
9266



beta-N-acetylglucosaminidase


Q13342_C686
SP140 Nuclear body protein
9267



SP140


Q9H930_C399
SP140L Nuclear body protein
9268



SP140-like protein


Q9C0B0_C696
UNK RING finger protein
9269



unkempt homolog


Q8TB03_C12
CXorf38 Uncharacterized
9270



protein CXorf38


P21580_C767
TNFAIP3 Tumor necrosis
9271



factor alpha-induced protein 3


O94906_C698
PRPF6 Pre-mRNA-processing
9272



factor 6


P43304_C385
GPD2 Glycerol-3-phosphate
9273



dehydrogenase, mitochondrial


Q9H4E7_C267
DEF6 Differentially expressed
9274



in FDCP 6 homolog


Q8NEM7_C298
FAM48A Protein FAM48A
9275


O75367_C286
H2AFY Core histone macro-
9276



H2A.1


O00148_C197
DDX39A ATP-dependent
9277



RNA helicase DDX39A


P40926_C275
MDH2 Malate dehydrogenase,
9278



mitochondrial


Q6P2E9_C249
EDC4 Enhancer of mRNA-
9279



decapping protein 4


Q9Y6K9_C54
IKBKG NF-kappa-B essential
9280



modulator


Q8TDB6_C159
DTX3L E3 ubiquitin-protein
9281



ligase DTX3L


Q5SSJ5_C359
HP1BP3 Heterochromatin
9282



protein 1-binding protein 3


P41252_C87
IARS Isoleucine--tRNA
9283



ligase, cytoplasmic


P28838_C445
LAP3 Cytosol aminopeptidase
9284


P62979_C144
RPS27A Ubiquitin-40S
9285



ribosomal protein S27a


Q29RF7_C1084
PDS5A Sister chromatid
9286



cohesion protein PDS5



homolog A


Q9UPN7_C437
PPP6R1 Serine/threonine-
9287



protein phosphatase 6



regulatory


Q04206_C38
RELA Transcription factor
9288



p65


Q9BTT0_C87
ANP32E Acidic leucine-rich
9289



nuclear phosphoprotein 32



family


Q6ZMZ3_C251
SYNE3 Nesprin-3
9290


Q8N201_C969
INTS1 Integrator complex
9291



subunit 1


Q7Z591_C1078
AKNA AT-hook-containing
9292



transcription factor


Q9ULT8_C1995
HECTD1 E3 ubiquitin-protein
9293



ligase HECTD1


Q8IZL8_C239
PELP1 Proline-, glutamic
9294



acid- and leucine-rich protein


Q7Z6I6_C1021
ARHGAP30 Rho GTPase-
9295



activating protein 30


Q8NDX1_C988
PSD4 PH and SEC7 domain-
9296



containing protein 4


Q92598_C658
HSPH1 Heat shock protein
9297



105 kDa


Q15020_C537
SART3 Squamous cell
9298



carcinoma antigen recognized



by T-cells 3


Q9UJC3_C432
HOOK1 Protein Hook
9299



homolog 1


Q9BQG0_C1031
MYBBP1A Myb-binding
9300



protein 1A


O00170_C208
AIP AH receptor-interacting
9301



protein


O60244_C729
MED14 Mediator of RNA
9302



polymerase II transcription



subunit


Q9NUB1_C422
ACSS1 Acetyl-coenzyme A
9303



synthetase 2-like,



mitochondrial


O76074_C447
PDE5A cGMP-specific 3,5-
9304



cyclic phosphodiesterase


Q96EY5_C231
FAM125A Multivesicular
9305



body subunit 12A


Q9P2I0_C621
CPSF2 Cleavage and
9306



polyadenylation specificity



factor subunit


Q9NQC7_C129
CYLD Ubiquitin carboxyl-
9307



terminal hydrolase CYLD


P49903_C31
SEPHS1 Selenide, water
9308



dikinase 1


P22102_C41
GART Trifunctional purine
9309



biosynthetic protein adenosin


Q13464_C1206
ROCK1 Rho-associated
9310



protein kinase 1


Q01813_C112
PFKP 6-phosphofructokinase
9311



type C


P16188_C188
HLA-A HLA class I histocompatibility
9312



antigen, A-30 alpha


P18463_C188
HLA-B HLA class I histocompatibility
9313



antigen, B-37 alpha


P30499_C188
HLA-C HLA class I histocompatibility
9314



antigen, Cw-1 alpha


P30492_C188
HLA-B HLA class I histocompatibility
9315



antigen, B-54 alpha


Q29940_C188
HLA-B HLA class I histocompatibility
9316



antigen, B-59 alpha


F8VZB9_C225
HLA-C HLA class I histocompatibility
9317



antigen, Cw-14 alpha


P10321_C188
HLA-C HLA class I histocompatibility
9318



antigen, Cw-7 alpha


Q96Q15_C3401
SMG1 Serine/threonine-
9319



protein kinase SMG1


P27635_C71
RPL10 60S ribosomal protein
9320



L10


P49756_C83
RBM25 RNA-binding protein
9321



25


Q8NE71_C758
ABCF1 ATP-binding cassette
9322



sub-family F member 1


O95696_C441
BRD1 Bromodomain-
9323



containing protein 1


Q9NXR7_C34
BRE BRCA1-A complex
9324



subunit BRE


O00478_C512
BTN3A3 Butyrophilin
9325



subfamily 3 member A3


O60942_C419
RNGTT mRNA-capping
9326



enzyme


Q16831_C17
UPP1 Uridine phosphorylase 1
9327


Q14142_C20
TRIM14 Tripartite motif-
9328



containing protein 14


O75367_C276
H2AFY Core histone macro-
9329



H2A.1


Q15052_C57
ARHGEF6 Rho guanine
9330



nucleotide exchange factor 6


P35626_C340
ADRBK2 Beta-adrenergic
9331



receptor kinase 2


P25098_C340
ADRBK1 Beta-adrenergic
9332



receptor kinase 1


P15428_C182
HPGD 15-
9333



hydroxyprostaglandin



dehydrogenase


Q96FZ2_C131
C3orf37 UPF0361 protein
9334



C3orf37


Q9Y2H0_C736
DLGAP4 Disks large-
9335



associated protein 4


Q8TCU4_C2878
ALMS1 Alstrom syndrome
9336



protein 1


O95801_C238
TTC4 Tetratricopeptide repeat
9337



protein 4


O95571_C219
ETHE1 Protein ETHE1,
9338



mitochondrial


Q9H4Z3_C29
PCIF1 Phosphorylated CTD-
9339



interacting factor 1


P55957_C15
BID BH3-interacting domain
9340



death agonist


P49458_C39
SRP9 Signal recognition
9341



particle 9 kDa protein


Q9NQ88_C161
TIGAR Fructose-2,6-
9342



bisphosphatase TIGAR


P22234_C63
PAICS Multifunctional protein
9343



ADE2


P35611_C253
ADD1 Alpha-adducin
9344


P19474_C463
TRIM21 E3 ubiquitin-protein
9345



ligase TRIM21


Q12874_C103
SF3A3 Splicing factor 3A
9346



subunit 3


Q03188_C612
CENPC1 Centromere protein
9347



C 1


P42166_C518
TMPO Lamina-associated
9348



polypeptide 2, isoform alpha


Q9NY12_C80
GAR1 H/ACA
9349



ribonucleoprotein complex



subunit 1


Q10567_C241
AP1B1 AP-1 complex subunit
9350



beta-1


Q96F86_C499
EDC3 Enhancer of mRNA-
9351



decapping protein 3


Q86UV5_C986
USP48 Ubiquitin carboxyl-
9352



terminal hydrolase 48


P49368_C213
CCT3 T-complex protein 1
9353



subunit gamma


P08559_C91
PDHA1 Pyruvate
9354



dehydrogenase E1 component



subunit alpha, mitochondrial


Q96SZ5_C18
ADO 2-aminoethanethiol
9355



dioxygenase


Q92974_C715
ARHGEF2 Rho guanine
9356



nucleotide exchange factor 2


Q92597_C289
NDRG1 Protein NDRG1
9357


Q9BZF2_C466
OSBPL7 Oxysterol-binding
9358



protein-related protein 7


Q9BQ69_C186
MACROD1 O-acetyl-ADP-
9359



ribose deacetylase MACROD1


Q14738_C17
PPP2R5D Serine/threonine-
9360



protein phosphatase 2A 56



kDa regulatory subunit, delta



isoform


P55210_C186
CASP7 Caspase-7
9361


P31939_C241
ATIC Bifunctional purine
9362



biosynthesis protein PURH


O00329_C366
PIK3CD Phosphatidylinositol
9363



4,5-bisphosphate 3-kinase



catalytic subunit delta isoform


Q9NZT2_C417
OGFR Opioid growth factor
9364



receptor


Q96I25_C302
RBM17 Splicing factor 45
9365



CPTK


Q13158_C98
FADD Protein FADD
9366


P52948_C1312
NUP98 Nuclear pore complex
9367



protein Nup98-Nup96


Q7Z5K2_C964
WAPAL Wings apart-like
9368



protein homolog


Q8NI37_C57
PPTC7 Protein phosphatase
9369



PTC7 homolog


Q9Y6Y8_C604
SEC23IP SEC23-interacting
9370



protein


Q969E8_C114
TSR2 Pre-rRNA-processing
9371



protein TSR2 homolog


Q9UEW8_C82
STK39 STE20/SPS1-related
9372



proline-alanine-rich protein



kinase


Q9P032_C87
NDUFAF4 NADH
9373



dehydrogenase


Q7L2J0_C244
MEPCE 7SK snRNA
9374



methylphosphate capping



enzyme


Q70CQ2_C741
USP34 Ubiquitin carboxyl-
9375



terminal hydrolase 34


Q08378_C1403
GOLGA3 Golgin subfamily A
9376



member 3


Q14C86_C741
GAPVD1 GTPase-activating
9377



protein and VPS9 domain-



containing protein 1


O00267_C626
SUPT5H Transcription
9378



elongation factor SPT5


P51159_C188
RAB27A Ras-related protein
9379



Rab-27A


Q9NZ63_C145
C9orf78 Uncharacterized
9380



protein C9orf78


P15374_C95
UCHL3 Ubiquitin carboxyl-
9381



terminal hydrolase isozyme L3


Q9H9A5_C633
CNOT10 CCR4-NOT
9382



transcription complex subunit



10


Q99614_C28
TTC1 Tetratricopeptide repeat
9383



protein 1


Q8ND71_C75
GIMAP8 GTPase IMAP
9384



family member 8


P11171_C224
EPB41 Protein 4.1
9385


Q9H400_C138
LIME1 Lck-interacting
9386



transmembrane adapter 1


Q9BVC5_C10
C2orf49 Ashwin
9387


Q15007_C270
WTAP Pre-mRNA-splicing
9388



regulator WTAP


P17987_C76
TCP1 T-complex protein 1
9389



subunit alpha


H7BZ11_C99
Uncharacterized protein
9390


Q969Q0_C88
RPL36AL 60S ribosomal
9391



protein L36a-like


Q9NS86_C187
LANCL2 LanC-like protein 2
9392


Q9H7N4_C675
SCAF1 Splicing factor,
9393



arginine/serine-rich 19


Q9Y3S1_C326
WNK2 Serine/threonine-
9394



protein kinase WNK2


Q9BYP7_C278
WNK3 Serine/threonine-
9395



protein kinase WNK3


Q9H4A3_C352
WNK1 Serine/threonine-
9396



protein kinase WNK1


Q8IYL3_C124
C1orf174 UPF0688 protein
9397



C1orf174


Q86YS7_C449
KIAA0528 Uncharacterized
9398



protein KIAA0528


Q86UW7_C1052
CADPS2 Calcium-dependent
9399



secretion activator 2


Q9UBS0_C348
RPS6KB2 Ribosomal protein
9400



S6 kinase beta-2


O60232_C152
SSSCA1 Sjoegren
9401



syndrome/scleroderma



autoantigen 1


Q9NZT2_C87
OGFR Opioid growth factor
9402



receptor


Q8N3D4_C1364
EHBP1L1 EH domain-binding
9403



protein 1-like protein 1


Q14980_C1729
NUMA1 Nuclear mitotic
9404



apparatus protein 1


Q15365_C118
PCBP1 Poly(rC)-binding
9405



protein 1


Q9UP83_C64
COG5 Conserved oligomeric
9406



Golgi complex subunit 5


Q5RKV6_C117
EXOSC6 Exosome complex
9407



component MTR3


Q96T23_C1436
RSF1 Remodeling and spacing
9408



factor 1


P13727_C147
PRG2 Bone marrow
9409



proteoglycan


Q6NYC8_C276
PPP1R18 Phostensin
9410


O60282_C393
KIF5C Kinesin heavy chain
9411



isoform 5C


Q92616_C2015
GCN1L1 Translational
9412



activator GCN1


O75808_C101
SOLH Calpain-15
9413


Q9UQ35_C1029
SRRM2 Serine/arginine
9414



repetitive matrix protein 2


Q8IZ73_C246
RPUSD2 RNA
9415



pseudouridylate synthase



domain-containing protein


Q92985_C394
IRF7 Interferon regulatory
9416



factor 7


P10914_C274
IRF1 Interferon regulatory
9417



factor 1


P50395_C202
GDI2 Rab GDP dissociation
9418



inhibitor beta


Q9UK61_C690
FAM208A Protein FAM208A
9419


Q9UPN7_C612
PPP6R1 Serine/threonine-
9420



protein phosphatase 6



regulatory


P07996_C813
THBS1 Thrombospondin-1
9421


Q96GW9_C428
MARS2 Methionine--tRNA
9422



ligase, mitochondrial


O14920_C716
IKBKB Inhibitor of nuclear
9423



factor kappa-B kinase subunit


Q7Z6I6_C20
ARHGAP30 Rho GTPase-
9424



activating protein 30


Q9NYV4_C1009
CDK12 Cyclin-dependent
9425



kinase 12


Q9UG63_C388
ABCF2 ATP-binding cassette
9426



sub-family F member 2


Q96AE4_C332
FUBP1 Far upstream element-
9427



binding protein 1


Q8N3P4_C1371
VPS8 Vacuolar protein
9428



sorting-associated protein 8



homolog


O15541_C15
RNF113A RING finger
9429



protein 113A


Q9UBN7_C426
HDAC6 Histone deacetylase 6
9430


P41252_C526
IARS Isoleucine--tRNA
9431



ligase, cytoplasmic


O60306_C28
AQR Intron-binding protein
9432



aquarius


Q8NFW8_C432
CMAS N-acylneuraminate
9433



cytidylyltransferase


Q9UHB4_C486
NDOR1 NADPH-dependent
9434



diflavin oxidoreductase 1


Q5TGY3_C1540
AHDC1 AT-hook DNA-
9435



binding motif-containing



protein 1


Q8IW35_C484
CEP97 Centrosomal protein of
9436



97 kDa


Q8WUA4_C212
GTF3C2 General transcription
9437



factor 3C polypeptide 2


Q6UUV7_C541
CRTC3 CREB-regulated
9438



transcription coactivator 3


Q5T4S7_C2449
UBR4 E3 ubiquitin-protein
9439



ligase UBR4


Q13155_C291
AIMP2 Aminoacyl tRNA
9440



synthase complex-interacting



multif


Q8TEU7_C1561
RAPGEF6 Rap guanine
9441



nucleotide exchange factor 6


P49792_C1196
RANBP2 E3 SUMO-protein
9442



ligase RanBP2


O14617_C574
AP3D1 AP-3 complex subunit
9443



delta-1


Q6P2E9_C54
EDC4 Enhancer of mRNA-
9444



decapping protein 4


Q5VZ89_C975
DENND4C DENN domain-
9445



containing protein 4C


P57772_C406
EEFSEC Selenocysteine-
9446



specific elongation factor


P30041_C91
PRDX6 Peroxiredoxin-6
9447


Q9H2G2_C1212
SLK STE20-like
9448



serine/threonine-protein kinase


Q16891_C603
IMMT Mitochondrial inner
9449



membrane protein


P55201_C570
BRPF1 Peregrin
9450


P09543_C49
CNP 2,3-cyclic-nucleotide 3-
9451



phosphodiesterase


P53701_C178
HCCS Cytochrome c-type
9452



heme lyase


O75376_C2056
NCOR1 Nuclear receptor
9453



corepressor 1


O60610_C164
DIAPH1 Protein diaphanous
9454



homolog 1


Q9ULL5_C112
PRR12 Proline-rich protein 12
9455


Q9UMS4_C230
PRPF19 Pre-mRNA-
9456



processing factor 19


Q99576_C112
TSC22D3 TSC22 domain
9457



family protein 3


Q9UFW8_C167
CGGBP1 CGG triplet repeat-
9458



binding protein 1


P62873_C25
GNB1 Guanine nucleotide-
9459



binding protein



G(I)/G(S)/G(T)


P04049_C27
RAF1 RAF proto-oncogene
9460



serine/threonine-protein kinase


Q9Y6A5_C426
TACC3 Transforming acidic
9461



coiled-coil-containing protein


Q9Y6A5_C502
TACC3 Transforming acidic
9462



coiled-coil-containing protein


Q9H6K4_C164
OPA3 Optic atrophy 3 protein
9463


P25205_C360
MCM3 DNA replication
9464



licensing factor MCM3


Q9UMS0_C213
NFU1 NFU1 iron-sulfur
9465



cluster scaffold homolog,



mitochondrial


Q08881_C143
ITK Tyrosine-protein kinase
9466



ITK/TSK


Q14974_C455
KPNB1 Importin subunit beta-
9467



1


Q8WVJ2_C14
NUDCD2 NudC domain-
9468



containing protein 2


O00139_C525
KIF2A Kinesin-like protein
9469



KIF2A


Q96T51_C184
RUFY1 RUN and FYVE
9470



domain-containing protein 1


P08575_C1178
PTPRC Receptor-type
9471



tyrosine-protein phosphatase C


P30626_C75
SRI Sorcin
9472


P63010_C95
AP2B1 AP-2 complex subunit
9473



beta


F5H5P2_C231
Uncharacterized protein
9474


P12694_C197
BCKDHA 2-oxoisovalerate
9475



dehydrogenase subunit alpha,



mitochondrial


Q14C86_C1129
GAPVD1 GTPase-activating
9476



protein and VPS9 domain-



containing protein 1


A6NKT7_C349
RGPD3 RanBP2-like and
9477



GRIP domain-containing



protein 3


Q9Y3L3_C56
SH3BP1 SH3 domain-binding
9478



protein 1


Q8IXH7_C293
TH1L Negative elongation
9479



factor C/D


Q53ET0_C675
CRTC2 CREB-regulated
9480



transcription coactivator 2


Q9BZH6_C363
WDR11 WD repeat-containing
9481



protein 11


Q9BZH6_C364
WDR11 WD repeat-containing
9482



protein 11


O95466_C733
FMNL1 Formin-like protein 1
9483


P30876_C1155
POLR2B DNA-directed RNA
9484



polymerase II subunit RPB2


P57764_C457
GSDMD Gasdermin-D
9485


P40925_C251
MDH1 Malate dehydrogenase,
9486



cytoplasmic


Q29RF7_C1116
PDS5A Sister chromatid
9487



cohesion protein PDS5



homolog A


P15498_C845
VAV1 Proto-oncogene vav
9488


Q8N163_C443
KIAA1967 DBIRD complex
9489



subunit KIAA1967


Q32P44_C307
EML3 Echinoderm
9490



microtubule-associated



protein-like 3


Q8WZ74_C759
CTTNBP2 Cortactin-binding
9491



protein 2


O60264_C165
SMARCA5 SWI/SNF-related
9492



matrix-associated actin-



dependent


Q9BY77_C338
POLDIP3 Polymerase delta-
9493



interacting protein 3


P81877_C82
SSBP2 Single-stranded DNA-
9494



binding protein 2


O43396_C34
TXNL1 Thioredoxin-like
9495



protein 1


Q7Z6Z7_C1879
HUWE1 E3 ubiquitin-protein
9496



ligase HUWE1


Q5VT06_C2716
CEP350 Centrosome-
9497



associated protein 350


O95466_C939
FMNL1 Formin-like protein 1
9498


Q13045_C576
FLII Protein flightless-1
9499



homolog


Q8WUW1_C43
BRK1 Protein BRICK1
9500


Q86UP2_C303
KTN1 Kinectin
9501


Q9BSQ5_C437
CCM2 Malcavernin
9502


O43149_C212
ZZEF1 Zinc finger ZZ-type
9503



and EF-hand domain-



containing


P19338_C543
NCL Nucleolin
9504


P10599_C35
TXN Thioredoxin
9505


Q9UNI6_C265
DUSP12 Dual specificity
9506



protein phosphatase 12


O43143_C774
DHX15 Putative pre-mRNA-
9507



splicing factor ATP-dependent



RN


P25205_C148
MCM3 DNA replication
9508



licensing factor MCM3


P48553_C1130
TRAPPC10 Trafficking
9509



protein particle complex



subunit 10


Q86XR8_C497
CEP57 Centrosomal protein of
9510



57 kDa


P27987_C178
ITPKB Inositol-trisphosphate
9511



3-kinase B


Q86W50_C432
METTL16 Methyltransferase-
9512



like protein 16


O15042_C320
U2SURP U2 snRNP-
9513



associated SURP motif-



containing protein


Q8IY17_C409
PNPLA6 Neuropathy target
9514



esterase


Q8TDD1_C586
DDX54 ATP-dependent RNA
9515



helicase DDX54


Q13905_C474
RAPGEF1 Rap guanine
9516



nucleotide exchange factor 1


A4D1P6_C246
WDR91 WD repeat-containing
9517



protein 91


P78371_C535
CCT2 T-complex protein 1
9518



subunit beta


Q08J23_C502
NSUN2 tRNA (cytosine(34)-
9519



C(5))-methyltransferase


Q8IV53_C781
DENND1C DENN domain-
9520



containing protein 1C


O94776_C261
MTA2 Metastasis-associated
9521



protein MTA2


E7ENX8_C353
Uncharacterized protein
9522


Q09666_C2806
AHNAK Neuroblast
9523



differentiation-associated



protein AHNA


Q63HN8_C2536
RNF213 E3 ubiquitin-protein
9524



ligase RNF213


Q96EP0_C59
RNF31 E3 ubiquitin-protein
9525



ligase RNF31


Q86VP6_C1007
CAND1 Cullin-associated
9526



NEDD8-dissociated protein 1


Q9H0J9_C474
PARP12 Polymerase
9527


Q14966_C259
ZNF638 Zinc finger protein
9528



638


Q8WWW0_C225
RASSF5 Ras association
9529



domain-containing protein 5


Q96K58_C126
ZNF668 Zinc finger protein
9530



668


Q12768_C385
KIAA0196 WASH complex
9531



subunit strumpellin


Q96CW5_C168
TUBGCP3 Gamma-tubulin
9532



complex component 3


Q9BYW2_C1471
SETD2 Histone-lysine N-
9533



methyltransferase SETD2


Q7Z2W4_C518
ZC3HAV1 Zinc finger CCCH-
9534



type antiviral protein 1


Q6XQN6_C533
NAPRT1 Nicotinate
9535



phosphoribosyltransferase


Q9Y6K9_C347
IKBKG NF-kappa-B essential
9536



modulator K.ASC*QESAR.I


P11142_C603
HSPA8 Heat shock cognate 71
9537



kDa protein K.VC*NPIITK.L


I3L2F9_C269
Uncharacterized protein
9538



K.NMMAAC*DPR.H


I3L2F9_C320
Uncharacterized protein
9539



K.TAVC*DIPPR.G


Q96JB2_C349
COG3 Conserved oligomeric
9540



Golgi complex subunit 3


A2A288_C517
ZC3H12D Probable
9541



ribonuclease ZC3H12D


Q9NR33_C85
POLE4 DNA polymerase
9542



epsilon subunit 4


Q8IXQ6_C728
PARP9 Polymerase
9543


Q13422_C254
IKZF1 DNA-binding protein
9544



Ikaros


Q14151_C361
SAFB2 Scaffold attachment
9545



factor B2


Q8TDX7_C298
NEK7 Serine/threonine-
9546



protein kinase Nek7


P61962_C256
DCAF7 DDB1- and CUL4-
9547



associated factor 7


Q00653_C738
NFKB2 Nuclear factor NF-
9548



kappa-B p100 subunit


O95671_C274
ASMTL N-acetylserotonin O-
9549



methyltransferase-like protein


Q92619_C599
HMHA1 Minor
9550



histocompatibility protein HA-



1


Q9UJV9_C568
DDX41 Probable ATP-
9551



dependent RNA helicase



DDX41


C9J4G0_C66
C17orf49 HCG32827, isoform
9552



CRA_d


I3L1I5_C221
Uncharacterized protein
9553


Q9Y6I9_C165
TEX264 Testis-expressed
9554



sequence 264 protein


Q66K14_C289
TBC1D9B TBC1 domain
9555



family member 9B


Q16875_C155
PFKFB3 6-phosphofructo-2-
9556



kinase/fructose-2,6-



bisphosphata


Q9UJX3_C329
ANAPC7 Anaphase-
9557



promoting complex subunit 7


Q9NR56_C27
MBNL1 Muscleblind-like
9558



protein 1


Q96L21_C105
RPL10L 60S ribosomal
9559



protein L10-like


P03989_C349
HLA-B HLA class I histocompatibility
9560



antigen, B-27 alpha


Q9Y4W2_C469
LAS1L Ribosomal biogenesis
9561



protein LAS1L


Q9P258_C144
RCC2 Protein RCC2
9562


Q96BX8_C88
MOB3A MOB kinase
9563



activator 3A


Q9BW27_C51
NUP85 Nuclear pore complex
9564



protein Nup85


Q9H582_C507
ZNF644 Zinc finger protein
9565



644


Q9H4A6_C84
GOLPH3 Golgi
9566



phosphoprotein 3


Q9H4A5_C70
GOLPH3L Golgi
9567



phosphoprotein 3-like


Q96DM3_C333
C18orf8 Uncharacterized
9568



protein C18orf8


P06239_C378
LCK Tyrosine-protein kinase
9569



Lck


Q95365_C125
HLA-B HLA class I histocompatibility
9570



antigen, B-38 alpha


P30453_C125
HLA-A HLA class I histocompatibility
9571



antigen, A-34 alpha


P30479_C125
HLA-B HLA class I histocompatibility
9572



antigen, B-41 alpha


Q29836_C125
HLA-B HLA class I histocompatibility
9573



antigen, B-67 alpha


P30466_C125
HLA-B HLA class I histocompatibility
9574



antigen, B-18 alpha


P30462_C125
HLA-B HLA class I histocompatibility
9575



antigen, B-14 alpha


P30460_C125
HLA-B HLA class I histocompatibility
9576



antigen, B-8 alpha


P01892_C125
HLA-A HLA class I histocompatibility
9577



antigen, A-2 alpha


Q9H7Z7_C110
PTGES2 Prostaglandin E
9578



synthase 2


Q8TEU7_C1368
RAPGEF6 Rap guanine
9579



nucleotide exchange factor 6


Q14CN2_C308
CLCA4 Calcium-activated
9580



chloride channel regulator 4


Q96FK6_C82
WDR89 WD repeat-containing
9581



protein 89


Q95365_C188
HLA-B HLA class I histocompatibility
9582



antigen, B-38 alpha


Q29836_C188
HLA-B HLA class I histocompatibility
9583



antigen, B-67 alpha


O14981_C939
BTAF1 TATA-binding
9584



protein-associated factor 172


Q9NXC5_C799
MIOS WD repeat-containing
9585



protein mio


Q13613_C117
MTMR1 Myotubularin-related
9586



protein 1


Q8IYL3_C215
C1orf174 UPF0688 protein
9587



C1orf174


Q14289_C899
PTK2B Protein-tyrosine
9588



kinase 2-beta


P26358_C62
DNMT1 DNA (cytosine-5)-
9589



methyltransferase 1


Q7RTR2_C561
NLRC3 Protein NLRC3
9590


Q9UKA4_C1488
AKAP11 A-kinase anchor
9591



protein 11


O76075_C194
DFFB DNA fragmentation
9592



factor subunit beta


O00221_C187
NFKBIE NF-kappa-B
9593



inhibitor epsilon


Q96F46_C703
IL17RA Interleukin-17
9594



receptor A


P36776_C682
LONP1 Lon protease
9595



homolog, mitochondrial


Q9UGK8_C189
SERGEF Secretion-regulating
9596



guanine nucleotide exchange



factor


Q9HAV4_C1131
XPO5 Exportin-5
9597


P38646_C366
HSPA9 Stress-70 protein,
9598



mitochondrial


P30084_C213
ECHS1 Enoyl-CoA hydratase,
9599



mitochondrial


Q9Y3P8_C126
SIT1 Signaling threshold-
9600



regulating transmembrane



adaptor 1


Q92844_C328
TANK TRAF family member-
9601



associated NF-kappa-B



activator


Q9NR50_C281
EIF2B3 Translation initiation
9602



factor eIF-2B subunit gamma


P36969_C102
GPX4 Phospholipid
9603



hydroperoxide glutathione



peroxidase, mitochondrial


P29144_C787
TPP2 Tripeptidyl-peptidase 2
9604


P40121_C282
CAPG Macrophage-capping
9605



protein


Q5JSL3_C592
DOCK11 Dedicator of
9606



cytokinesis protein 11


P52306_C85
RAP1GDS1 Rap1 GTPase-
9607



GDP dissociation stimulator 1


P61978_C205
HNRNPK Heterogeneous
9608



nuclear ribonucleoprotein K


P35250_C88
RFC2 Replication factor C
9609



subunit 2


Q96PY6_C276
NEK1 Serine/threonine-
9610



protein kinase Nek1


Q9Y5J1_C90
UTP18 U3 small nucleolar
9611



RNA-associated protein 18



homolog


O95365_C123
ZBTB7A Zinc finger and BTB
9612



domain-containing protein 7A


Q9ULG1_C1001
INO80 DNA helicase INO80
9613


O95801_C63
TTC4 Tetratricopeptide repeat
9614



protein 4


P57772_C55
EEFSEC Selenocysteine-
9615



specific elongation factor


Q96FE7_C228
PIK3IP1 Phosphoinositide-3-
9616



kinase-interacting protein 1


Q92945_C176
KHSRP Far upstream element-
9617



binding protein 2


P15121_C304
AKR1B1 Aldose reductase
9618


Q15149_C3017
PLEC Plectin
9619


Q12849_C476
GRSF1 G-rich sequence factor
9620



1


P55160_C338
NCKAP1L Nck-associated
9621



protein 1-like


P50990_C430
CCT8 T-complex protein 1
9622



subunit theta


P53597_C60
SUCLG1 Succinyl-CoA ligase
9623


Q9Y277_C229
VDAC3 Voltage-dependent
9624



anion-selective channel protein


P30481_C125
HLA-B HLA class I histocompatibility
9625



antigen, B-44 alpha


P04222_C125
HLA-C HLA class I histocompatibility
9626



antigen, Cw-3 alpha


Q96L91_C162
EP400 E1A-binding protein
9627



p400


Q9Y4E8_C264
USP15 Ubiquitin carboxyl-
9628



terminal hydrolase 15


Q8IZH2_C1450
XRN1 5-3 exoribonuclease 1
9629


Q29RF7_C581
PDS5A Sister chromatid
9630



cohesion protein PDS5



homolog A


Q3KQU3_C251
MAP7D1 MAP7 domain-
9631



containing protein 1


O60318_C1864
MCM3AP 80 kDa MCM3-
9632



associated protein


Q9NT62_C182
ATG3 Ubiquitin-like-
9633



conjugating enzyme ATG3


Q14511_C18
NEDD9 Enhancer of
9634



filamentation 1


O00139_C406
KIF2A Kinesin-like protein
9635



KIF2A


P09914_C138
IFIT1 Interferon-induced
9636



protein with tetratricopeptide


O60216_C35
RAD21 Double-strand-break
9637



repair protein rad21 homolog


P04222_C345
HLA-C HLA class I histocompatibility
9638



antigen, Cw-3 alpha


P57764_C38
GSDMD Gasdermin-D
9639


Q9Y520_C2340
PRRC2C Protein PRRC2C
9640


P62913_C150
RPL11 60S ribosomal protein
9641



L11


Q9Y2Y0_C149
ARL2BP ADP-ribosylation
9642



factor-like protein 2-binding



protein


Q16514_C143
TAF12 Transcription initiation
9643



factor TFIID subunit 12


O14526_C571
FCHO1 FCH domain only
9644



protein 1


Q6F5E8_C1339
RLTPR Leucine-rich repeat-
9645



containing protein 16C


Q9H7N4_C362
SCAF1 Splicing factor,
9646



arginine/serine-rich 19


Q8WW01_C13
TSEN15 tRNA-splicing
9647



endonuclease subunit Sen15


O15226_C424
NKRF NF-kappa-B-repressing
9648



factor


P40763_C712
STAT3 Signal transducer and
9649



activator of transcription 3


Q92608_C1083
DOCK2 Dedicator of
9650



cytokinesis protein 2


Q8TDZ2_C837
MICAL1 Protein-methionine
9651



sulfoxide oxidase MICAL1


Q9NRA8_C318
EIF4ENIF1 Eukaryotic
9652



translation initiation factor 4E



transporter


P29590_C227
PML Protein PML
9653


Q9UBU9_C252
NXF1 Nuclear RNA export
9654



factor 1


P61586_C159
RHOA Transforming protein
9655



RhoA









Table 5 illustrates an exemplary listing of cysteine-containing polypeptides. The cysteine residue of interest is denoted with (*).













TABLE 5





Protein

Cysteine

SEQ


Identifier

Residue

ID


(Accession No.)
Protein Name
Number
Sequence
NO:







O75874
Isocitrate
C269
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYV
9656



dehydrogenase

ELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV




1 (IDH1)

GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNIL






GGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQY






RATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFE






EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWP






LYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEA






QKIWYEHRLIDDMVAQAMKSEGGFIWAC*KNYD






GDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE






AAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGL






AHRAKLDNNKELAFFANALEEVSIETIEAGFMTK






DLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIK






LAQAKL






P48735
Isocitrate
C308
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQE
9657



dehdrogenase 

QPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIK




2 (IDH2)

EKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL






ATQKYSVAVKCATITPDEARVEEFKLKKMWKSP






NGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGR






HAHGDQYKATDEVADRAGTFKMVFTPKDGSGV






KEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQ






YAIQKKWPLYMSTKNTILICAYDGRFKDIFQEIFDK






HYKTDFDKNKCIWYEHRLIDDMVAQVLKSSGGFV






WAC*KNYDGDVQSDILAQGFGSLGLMTSVLVCP






DGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIA






SIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVE






TVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL






DTIKSNLDRALGRQ






Q14790
CASP8
C360
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQ
9658





EPIKDALMLFQRLQEKRMLEESNLSFLKELLFRIN






RLDLLITYLNTRKEEMERELQTPGRAQISAYRVM






LYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLL






DIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIIN






DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISD






SPREQDSESQTLDKVYQMKSICPRGYCLIINNHNF






AKAREKVPKLHSIRDRNGTHLDAGALTTTFEELH






FEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCI






LSHGDKGITYGTDGQEAPIYELTSQFTGLKCPSLA






GKPKVFFIQAC*QGDNYQKGIPVETDSEEQPYLE






MDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPA






EGTWYIQSLCQSLRERCPRGDDILTILTEVNYEV






SNKDDKKNMGKQMPQPTFTLRKKLVFPSD






Q92851
CASP10
C401
MKSQGQHWYS SSDKNCKVSF REKLLIIDSN
9659





LGVQDVENLK FLCIGLVPNKKLEKSSSASD






VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK






LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY






ELSEGIDSENLKDMIFLLKD SLPKTEMTSL






SFLAFLEKQGKIDEDNLTCL EDLCKTVVPK






LLRNIEKYKREKAIQIVTPP VDKEAESYQG






EEELVSQTDVKTFLEALPQE SWQNKHAGSN






GNRATNGAPSLVSRGMQGASANTLNSETSTKRA






AVYRMNRNHRGLCVIVNNHSFTSLKDR






QGTHICDAEILSHVFQWLGET VHIHNNVTKV






EMEMVLQKQKCNPAHADGDCFVFCILTHGRFGA






VYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ






AC*QGEEIQPSVSIEADALNPEQAPTSLQDSIPAEA






DFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK






LVPRMLKFLEKTMEIRGRKRTVWGAICQISATSLP






TAISAQTPRPPMRRWSSVS






Q99873
PRMT1
C109
MENFVATLANGMSLQPPLEEVSCGQAESSEICPNA
9660





EDMTSKDYYFDSYAHEGIHEEMLKDEVRTLTYRN






SMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGA






RKVIGIEC*SSISDYAVKIVKANKLDHVVTIIKGKV






EEVELPVEKVDIIISEWMGYCLFYESMLNTVLYAR






DKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHW






WENVYGFDMSCIICDVAIKEPLVDVVDPKQLVTN






ACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVH






ALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVF






YMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTI






DLDFKGQLCELSCSTDYRMR






Q9NYL2
MAP3 kinase
C22
MSSLGASFVQIKFDDLQFFENC*GGGSFGSVYRA
9661



MLTK (or

KWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFY




ZAK)

GVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDM






DHIMTWATDVAKGMHYLHMEAPVKVIHRDLKS






RNVVIAADGVLKCDFGASRFHNHTTHMSLVGTT






PWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREV






PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELL






HQCWEADAKICRPSFKQIISILESMSNDTSLPDKCN






SFLHNKAEWRCEIEATLERLKKLERDISFKEQELK






ERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDD






VYCWVQQLVRKGDSSAEMSVYASLFICENNITGK






RLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYI






NLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKP






GTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTN






LPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVT






YESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLA






IQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIAS






NTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQ






VPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSR






DSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNS






SPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNP






HQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEE






DSKVSEGGWTKVEYRKKPHRPSPAKTNKERARG






DHRGWRNF






P12268
IMPDH2
C140,
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYN
9662




C331
DFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSP






MDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANE






VRKVICKYEQGFITDPVVLSPKDRVRDVFEAKARH






GFC*GIPITDTGRMGSRLVGIISSRDIDFLKEEEHDC






FLEEIMTKREDLVVAPAGITLKEANEILQRSICKGK






LPIVNEDDELVAHARTDLKICNRDYPLASKDAKICQ






LLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSS






QGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQA






KNLIDAGVDALRVGMGSGSIC*ITQEVLACGRPQ






ATAVYKVSEYARRFGVPVIADGGIQNVGHIAKAL






ALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKY






RGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVS






GAVQDKGSIHKIVPYLIAGIQHSCQDIGAKSLTQV






RAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKR






LF






Q9NQ88
TIGAR
C114,
MARFALTVVRHGETRFNKEICHQGQGVDEPLSET
9663




C161
GFKQAAAAGIFLNNVKFTHAFSSDLMRTKQTMH






GILERSICFCICDMTVKYDSRLRERKYGVVEGICALS






ELRAMAKAAREEC*PVFTPPGGETLDQVKMRGID






FFEFLCQLILKEADQKEQFSQGSPSNC*LETSLAEI






FPLGKNHSSKVNSDSGIPGLAASVLVVSHGAYMR






SLFDYFLTDLKCSLPATLSRSELMSVTPNTGMSLFI






INFEEGREVICPTVQCICMNLQDHLNGLTETR






Q04759
PKCO
C14, C17
MSPFLRIGLSNFDC*GSC*QSCQGEAVNPYCAVLV
9664





KEYVESENGQMYIQKKPTMYPPWDSTFDAHINK






GRVMQIIVKGKNVDLISETTVELYSLAERCRKNN






GKTEIWLELKPQGRMLMNARYFLEMSDTKDMNE






FETEGFFALHQRRGAIKQAKVHHVKCHEFTATFF






PQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHICK






CIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFK






VYNYKSPTFCEHCGTLLWGLARQGLKCDACGMN






VHHRCQTKVANLCGINQKLMAEALAMIESTQQ






ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTP






GKREPQGISWESPLDEVDKMCHLPEPELNKERPSL






QIKLKTEDFILHKMLGKGSFGKVFLAEFKKTNQFF






AIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP






FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSC






HKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLD






NILLDKDGHIKIADFGMCKENNILGDAKTNTFCGT






PDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQ






SPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLL






VKLFVREPEKRLGVRGDIRQHPLFREINWEELERK






EIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRA






LINSMDQNMFRNFSFMNPGMERLIS






Q96SW2
Cereblon
C188,
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEV
9665




C287
EDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFH






GRTLHDDDSCQVIPVLPQVMMILTPGQTLPLQLFH






PQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGT






TAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRT






QSDGIQQAKVQILPEC*VLPSTMSAVQLESLNKCQ






IFPSKPVSREDQCSYKWWQKYQICRKFHCANLTS






WPRWLYSLYDAETLMDRIKKQLREWDENLKDDS






LPSNPIDFSYRVAAC*LPIDDVLRIQLLKIGSAIQRL






RCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCG






PMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEH






SWFPGYAWTVAQCKKASHIGWKFTATICKDMSP






QKFWGLTRSALLPTIPDTEDEISPDKVILCL









Table 6A-Table 6E illustrate a list of cysteine containing proteins and potential cysteine site of conjugation separated by protein class. Table 6A illustrates cysteine containing enzymes and potential cysteine conjugation site. Table 6B shows a list of cysteine containing transcription factors and regulators. Table 6C shows an exemplary list of cysteine containing channels, transporters and receptors. Table 6D illustrates an exemplary cysteine containing adapter, scaffolding, and modulator protein. Table 6E provides an exemplary list of uncategorized cysteine containing proteins.












TABLE 6A







Cysteine



Identifier
Protein Name
Location
Protein Class







O14920
IKBKB Inhibitor of nuclear factor kappa-B kinase subunit
C464
Enzyme


O14933
UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 PCTK
C98
Enzyme


O94953
KDM4B Lysine-specific demethylase 4B
C694
Enzyme


P00813
ADA Adenosine deaminase
C75
Enzyme


P09211
GSTP1 Glutathione S-transferase P
C48
Enzyme


P15374
UCHL3 Ubiquitin carboxyl-terminal hydrolase isozyme L3
C95
Enzyme


P16455
MGMT Methylated-DNA--protein-cysteine methyltransferase
C145; C150
Enzyme


P17812
CTP synthase 1
C491
Enzyme


P19447
ERCC3 TFIIH basal transcription factor complex helicase
C342
Enzyme


P21580
TNFAIP3 Tumor necrosis factor alpha-induced protein 3
C54
Enzyme


P24752
ACAT1 Acetyl-CoA acetyltransferase, mitochondrial
C119; C126;
Enzyme




C196; C413


P40261
Nicotinamide N-methyltransferase
C165
Enzyme


P41226
UBA7 Ubiquitin-like modifier-activating enzyme 7
C599
Enzyme


P42575
CASP2 Caspase-2
C370
Enzyme


P43403
ZAP70 Tyrosine-protein kinase ZAP-70
C117
Enzyme


P48735
IDH2 Isocitrate dehydrogenase
C308
Enzyme


P51617
IRAK1 Interleukin-1 receptor-associated kinase 1
C608
Enzyme


P61081
NEDD8-conjugating enzyme Ubc12
C47
Enzyme


P61088
Ubiquitin-conjugating enzyme E2 N
C87
Enzyme


P68036
UBE2L3 Ubiquitin-conjugating enzyme E2 L3
C86
Enzyme


Q00535
CDK5 Cyclin-dependent kinase 5
C157
Enzyme


Q04759
PRKCQ Protein kinase C theta type
C14; C17
Enzyme


Q06124
Tyrosine-protein phosphatase non-receptor type 11
C573
Enzyme


Q09472
EP300 Histone acetyltransferase p300
C1738
Enzyme


Q14790
CASP8 Caspase-8
C360
Enzyme


Q15084
PDIA6 Protein disulfide-isomerase A6
C55; C58;
Enzyme




C190; C193


Q15910
EZH2 Histone-lysine N-methyltransferase EZH2
C503
Enzyme


Q16763
UBE2S Ubiquitin-conjugating enzyme E2 S
C118
Enzyme


Q16822
PCK2 Phosphoenolpyruvate carboxykinase
C306
Enzyme


Q16875
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
C155
Enzyme


Q16877
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphata
C159
Enzyme


Q6L8Q7
PDE12 2,5-phosphodiesterase 12
C108
Enzyme


Q70CQ2
USP34 Ubiquitin carboxyl-terminal hydrolase 34
C741; C1090
Enzyme


Q86UV5
USP48 Ubiquitin carboxyl-terminal hydrolase 48
C39
Enzyme


Q92851
Caspase-10
C401
Enzyme


Q93009
USP7 Ubiquitin carboxyl-terminal hydrolase 7
C223; C315
Enzyme


Q96FA3
PELI1 E3 ubiquitin-protein ligase pellino homolog 1
C282
Enzyme


Q96JH7
VCPIP1 Deubiquitinating protein VCIP135
C219
Enzyme


Q96RU2
USP28 Ubiquitin carboxyl-terminal hydrolase 28
C171; C733
Enzyme


Q99873
PRMT1 Protein arginine N-methyltransferase 1
C109
Enzyme


Q9C0C9
UBE2O Ubiquitin-conjugating enzyme E2 O
C375
Enzyme


Q9NRW4
Dual specificity protein phosphatase 22
C124
Enzyme


Q9NWZ3
IRAK4 Interleukin-1 receptor-associated kinase 4
C13
Enzyme


Q9NYL2
MLTK Mitogen-activated protein kinase kinase kinase MLT
C22
Enzyme


Q9UPT9
USP22 Ubiquitin carboxyl-terminal hydrolase 22
C44; C71
Enzyme


Q9Y3Z3
SAMHD1 SAM domain and HD domain-containing protein 1
C522
Enzyme


Q9Y4C1
KDM3A Lysine-specific demethylase 3A
C251
Enzyme


Q9Y5T5
USP16 Ubiquitin carboxyl-terminal hydrolase 16
C205
Enzyme



















TABLE 6B







Cysteine



Identifier
Protein Name
Location
Protein Class







O75362
ZNF217 Zinc finger protein 217
C286
Transcription





factors and





regulators


P04150
NR3C1 Glucocorticoid receptor
C302; C622
Transcription





factors and





regulators


P09086
POU2F2 POU domain, class 2, transcription factor 2
C346
Transcription





factors and





regulators


P40763
STAT3 Signal transducer and activator of transcription 3
C259
Transcription





factors and





regulators


P48200
IREB2 Iron-responsive element-binding protein 2
C137
Transcription





factors and





regulators


Q01201
RELB Transcription factor RelB
C109
Transcription





factors and





regulators


Q02556
IRF8 Interferon regulatory factor 8
C306
Transcription





factors and





regulators


Q15306
IRF4 Interferon regulatory factor 4
C194
Transcription





factors and





regulators


Q7Z2W4
ZC3HAV1 Zinc finger CCCH-type antiviral protein 1
C645
Transcription





factors and





regulators


Q8TAQ2
SMARCC2 SWI/SNF complex subunit SMARCC2
C145
Transcription





factors and





regulators



















TABLE 6C







Cysteine



Identifier
Protein Name
Location
Protein Class







P63244
GNB2L1 Guanine nucleotide-binding protein subunit
C182
Channels,



beta-2-like 1

Transporters,





Receptors


Q16186
Proteasomal ubiquitin receptor ADRM1
C88
Channels,





Transporters,





Receptors


Q9HB90
RRAGC Ras-related GTP-binding protein C
C358; C377
Channels,





transporters,





and receptors



















TABLE 6D







Cysteine



Identifier
Protein Name
Location
Protein Class







P14598
NCF1 Neutrophil cytosol factor 1
C378
Adapter,





scaffolding,





modulator proteins



















TABLE 6E







Cysteine



Identifier
Protein Name
Location
Protein Class







O00170
AIP AH receptor-interacting protein
C122
Uncategorized


O00541
PES1 Pescadillo homolog
C272; C361
Uncategorized


O00622
CYR61 Protein CYR61
C39; C70;
Uncategorized




C134


O14980
XPO1 Exportin-1
C34; C528;
Uncategorized




C1070


P50851
LRBA Lipopolysaccharide-responsive and beige-like
C1704; C2675
Uncategorized



anchor protein


Q96GG9
DCUN1D1 DCN1-like protein 1
C115
Uncategorized









While preferred embodiments of the present disclosure have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the disclosure. It should be understood that various alternatives to the embodiments of the disclosure described herein may be employed in practicing the disclosure. It is intended that the following claims define the scope of the disclosure and that methods within the scope of these claims and their equivalents be covered thereby.

Claims
  • 1. A method of modulating an immune response in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a small molecule fragment of Formula (I):
  • 2. The method of claim 1, wherein the small molecule fragment interacts with an endogenous cysteine-containing polypeptide expressed in the subject to form a cysteine-containing polypeptide-small molecule fragment adduct.
  • 3. The method of claim 1 or 2, wherein the small molecule fragment is covalently bond to a cysteine residue of the cysteine-containing polypeptide.
  • 4. The method of claim 2, wherein the cysteine-containing polypeptide-small molecule fragment adduct induces an immune response.
  • 5. The method of claim 2 or 4, wherein the cysteine-containing polypeptide-small molecule fragment adduct induces a humoral immune response or a cell-mediated immune response.
  • 6. The method of claim 2, wherein the cysteine-containing polypeptide-small molecule fragment adduct increases an immune response relative to a control.
  • 7. The method of claim 6, wherein the control is the level of an immune response in the subject prior to administration of the small molecule fragment or the level of an immune response in a subject who has not been exposed to the small molecule fragment.
  • 8. The method of claim 2, wherein the cysteine-containing polypeptide is overexpressed in a disease or condition.
  • 9. The method of claim 2, wherein the cysteine-containing polypeptide comprises one or more mutations, optionally overexpressed in a disease or condition.
  • 10. The method of claim 8 or 9, wherein the disease or condition is cancer.
  • 11. The method of claim 2, wherein the cysteine-containing polypeptide comprises a biologically active cysteine site, optionally located about 10 Å or less to an active-site ligand or residue.
  • 12. The method of claim 2, wherein the cysteine-containing polypeptide comprises a protein illustrated in Tables 1-6.
  • 13. The method of claim 2, wherein the cysteine-containing polypeptide comprises cereblon.
  • 14. The method of claim 2, wherein the cysteine-containing polypeptide is at most 50 amino acid residues in length.
  • 15. The method of claim 14, wherein the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 80%, 85%, 90%, 95%, 96%, 9%, 98%, or 99% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655.
  • 16. The method of claim 1, wherein F is a small molecule fragment moiety illustrated in FIG. 1.
  • 17. An isolated and purified antibody or its binding fragment thereof comprising a heavy chain CDR1, CDR2 and CDR3 sequence and a light chain CDR1, CDR2 and CDR3 sequence, wherein the heavy chain and light chain CDRs interact with a cysteine-containing polypeptide that is covalently bond to a small molecule fragment, wherein the small molecule fragment is a small molecule fragment of Formula (I):
  • 18. The isolated and purified antibody or its binding fragment thereof of claim 17, wherein the antibody or its binding fragment thereof comprises a humanized antibody or binding fragment thereof, chimeric antibody or binding fragment thereof, monoclonal antibody or binding fragment thereof, monovalent Fab′, divalent Fab2, single-chain variable fragment (scFv), diabody, minibody, nanobody, single-domain antibody (sdAb), or camelid antibody or binding fragment thereof.
  • 19. The isolated and purified antibody or its binding fragment thereof of claim 17, wherein F is a small molecule fragment moiety illustrated in FIG. 1.
  • 20. The isolated and purified antibody or its binding fragment thereof of claim 17, wherein the cysteine-containing polypeptide comprises a protein illustrated in Tables 1-6.
  • 21. The isolated and purified antibody or its binding fragment thereof of claim 17, wherein the cysteine-containing polypeptide comprises cereblon.
  • 22. The isolated and purified antibody or its binding fragment thereof of claim 17, wherein the cysteine-containing polypeptide is at most 50 amino acid residues in length.
  • 23. The isolated and purified antibody or its binding fragment thereof of claim 22, wherein the cysteine-containing polypeptide comprises an isolated and purified polypeptide comprising at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity to at least seven contiguous amino acids of an amino acid sequence selected from SEQ ID NOs: 1-9655.
  • 24. A vaccine comprising a small molecule fragment of Formula (I):
  • 25. The vaccine of claim 24, wherein F is a small molecule fragment moiety illustrated in FIG. 1.
  • 26. A kit comprising an isolated and purified antibody or its binding fragment thereof of claims 17-23, or a vaccine of claims 24-25.
  • 27. A method of modulating cereblon activity, comprising: contacting a cell expressing cereblon with a small molecule fragment of Formula (I):
  • 28. The method of claim 27, wherein F is a small molecule fragment moiety illustrated in FIG. 1.
  • 29. The method of claim 27, wherein F optionally comprises a second reactive moiety.
  • 30. The method of claim 27, wherein the cell is a mammalian cell.
  • 31. The method of claim 27, wherein the method is an in vivo method.
CROSS-REFERENCE

This application claims the benefit of U.S. Provisional Application No. 62/345,715, filed on Jun. 3, 2016, which is incorporated herein by reference in its entirety.

PCT Information
Filing Document Filing Date Country Kind
PCT/US17/35748 6/2/2017 WO 00
Provisional Applications (1)
Number Date Country
62345715 Jun 2016 US