Claims
- 1. A method of treating carcinoma susceptible to treatment in a warm blooded mammal comprising administering to said mammal a safe and effective amount of a 1H-1,2,4-triazole derivative of the formula:
- 2. A method according to claim 1 wherein said 1H-1,2,4-triazole derivative is selected from the group consisting of:
1-[2-(2,4-dichlorophenyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole; 1-[2-(2,4-dichlorophenyl)-4-methyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole, 1-[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole, 1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole, 1-[2-(2,4-dichlorophenyl)-4-pentyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole.
- 3. A method according to claim 1 wherein said 1H-1,2,4-triazole derivative is 1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole.
- 4. A method according to claim 1 wherein the carcinoma is breast cancer.
- 5. A method according to claim 1 wherein the carcinoma is head or neck cancer.
- 6. A method according to claim 1 wherein the carcinoma is melanoma.
- 7. A method according to claim 1 wherein the carcinoma is ovarian cancer.
- 8. A method according to claim 1 wherein the carcinoma is colon cancer.
- 9. A method according to claim 1 wherein the carcinoma is lung cancer.
- 10. A method according to claim 1 wherein the carcinoma is stomach cancer.
- 11. A method according to claim 1 wherein the carcinoma is uterine cancer.
- 12. A method of treating a viral infection susceptible to treatment in a warm blooded mammal comprising administering to said mammal a safe and effective amount of 1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole.
- 13. A method according to claim 12 wherein the viral infection is an influenza infection.
- 14. A method according to claim 12 wherein the viral infection is a rhinoviral infection.
- 15. A pharmaceutical kit comprising
- 16. A pharmaceutical kit of claim 15 wherein the 1H-1,2,4-triazole derivative is 1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole.
- 17. A pharmaceutical kit comprising
- 18. A pharmaceutical kit of claim 17 wherein the 1H-1,2,4-triazole derivative is 1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole.
- 19. A pharmaceutical kit of claim 18 wherein the instructions are for use in treating influenza.
- 20. A pharmaceutical kit of claim 18 wherein the instructions are for use in treating a rhinoviral infection.
Parent Case Info
[0001] The present application is a continuation-in-part application of U.S. Ser. No. 09/469,389 filed Dec. 22, 1999, which is a continuation application of U.S. Ser. No. 09/138,058 filed Aug. 21, 1998, now U.S. Pat. No. 6,025,377; which is a divisional application of U.S. Ser. No. 08/792,741 filed Feb. 3, 1997, now U.S. Pat. No. 5,872,142; which is a divisional application of U.S. Ser. No. 08/473,819 filed Jun. 7, 1995, now U.S. Pat. No. 5,770,616. The patents and patent application are incorporated by reference herein.
Divisions (2)
|
Number |
Date |
Country |
Parent |
08792741 |
Feb 1997 |
US |
Child |
09138058 |
Aug 1998 |
US |
Parent |
08473819 |
Jun 1995 |
US |
Child |
08792741 |
Feb 1997 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09138058 |
Aug 1998 |
US |
Child |
09469389 |
Dec 1999 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09469389 |
Dec 1999 |
US |
Child |
09851513 |
May 2001 |
US |