Claims
- 1. A compound having the formula: ##STR13## wherein R.sup.1 and R.sup.2 each independently represent a C.sub.8 -C.sub.24 saturated or unsaturated hydrocarbon chain, uninterrupted or interrupted by from 1 to 3 heteroatom moieties selected from the group consisting of --O--, --S--, --NH-- and --NR--;
- X represents a member selected from the group consisting of --CH.sub.2 --, --O--, --S--, --NH-- and --NR--;
- wherein R is a lower alkyl group having from 1 to 4 carbon atoms;
- n is an integer of from 1 to 2; and
- A.sup.- is an anion.
- 2. A compound of claim 1, wherein R.sup.1 and R.sup.2 each independently represent a C.sub.8 -C.sub.24 saturated or unsaturated hydrocarbon chain.
- 3. A compound of claim 1, wherein R.sup.1 and R.sup.2 each independently represent a C.sub.12 -C.sub.20 saturated hydrocarbon chain.
- 4. A compound of claim 1, wherein R.sup.1 and R.sup.2 each independently represent a C.sub.12 -C.sub.20 unsaturated hydrocarbon chain.
- 5. A compound of claim 1, wherein n is 1.
- 6. A compound of claim 1, wherein R.sup.1 and R.sup.2 each independently represent a C.sub.12 -C.sub.16 unsaturated hydrocarbon chain, X is --O--, and n is 1.
- 7. A compound of claim 1, wherein R.sup.1 represents a C.sub.18 -unsaturated hydrocarbon chain, R.sup.2 represents a C.sub.17 unsaturated hydrocarbon chain, X is --O--, and n is 1.
- 8. A compound of claim 7, wherein R.sup.1 and R.sup.2 each contain a single double bond in the cis orientation.
- 9. A compound according to claim 1 having the formula: ##STR14##10.
- 10. A compound according to claim 1 having the formula:
- 11. A lipid vesicle composition containing a lipid of the formula: wherein
- R.sup.1 and R.sup.2 each independently represent a C.sub.8 -C.sub.24 saturated or unsaturated hydrocarbon chain, uninterrupted or interrupted by from 1 to 3 heteroatom moieties selected from the group consisting of --O--, --S--, --NH-- and --NR--;
- X represents a member selected from the group consisting of --CH.sub.2 --, --O--, --S--, --NH-- and --NR--;
- wherein R is a lower alkyl group having from 1 to 4 carbon atoms;
- n is an integer of from 1 to 2; and
- A.sup.- is an anion.
- 12. A composition of claim 11, wherein R.sup.1 and R.sup.2 each independently represent a C.sub.8 -C.sub.24 saturated or unsaturated hydrocarbon chain.
- 13. A composition of claim 11, wherein R.sup.1 and R.sup.2 each independently represent a C.sub.12 -C.sub.20 saturated hydrocarbon chain.
- 14. A composition of claim 11, wherein R.sup.1 and R.sup.2 each independently represent a C.sub.12 -C.sub.20 unsaturated hydrocarbon chain.
- 15. A composition of claim 11, wherein n is 1.
- 16. A composition of claim 11, wherein R.sup.1 and R.sup.2 each independently represent a C.sub.12 -C.sub.16 unsaturated hydrocarbon chain, X is --O--, and n is 1.
- 17. A composition of claim 11, wherein R.sup.1 represents a C.sub.18 -unsaturated hydrocarbon chain, R.sup.2 represents a C.sub.17 unsaturated hydrocarbon chain, X is --O--, and n is 1.
- 18. A composition of claim 17, wherein R.sup.1 and R.sup.2 each contain a single double bond in the cis orientation.
- 19. A composition of claim 11, further comprising cholesterol.
- 20. A composition of claim 11, further comprising dilauroylphosphatidylethanolamine.
- 21. A composition of claim 11 which is in the form of unilamellar vesicles.
- 22. A lipid-nucleic acid composition comprising a nucleic acid and a compound of formula: ##STR15## wherein R.sup.1 and R.sup.2 each independently represent a C.sub.8 -C.sub.24 saturated or unsaturated hydrocarbon chain, uninterrupted or interrupted by from 1 to 3 heteroatom moieties selected from the group consisting of --O--, --S--, --NH-- and --NR--;
- X represents a member selected from the group consisting of --CH.sub.2 --, --O--, --S--, --NH-- and --NR--;
- wherein R is a lower alkyl group having from 1 to 4 carbon atoms;
- n is an integer of from 1 to 2; and
- A.sup.- is an anion.
Parent Case Info
This application claims the benefit of U.S. Provisional Application No. 60/065,859, filed Nov. 14, 1997.
US Referenced Citations (6)
Foreign Referenced Citations (1)
Number |
Date |
Country |
95-14380 |
Jun 1995 |
WOX |