| Ruschig et al., “Preparation of 17α-hydroxy-20-keto Steroids from 17(20)-en-20-acetamino Steroids”, Chem. Ber. (1955) 88(6):883-894, including an English language abstract (Exhibit 2). |
| Armstrong et al., “Acylation Effects on Chiral Recognition of Racemic Amines and Alcohols by New Polar and Non-Polar Cyclodextrin Derivative Gas Chromatographic Phases”, J. Chromatography (1990) 502: 154-159 (Exhibit 61). |
| Askin et al., “Highly Diastereoselective Alkylations of Chiral Amide Enolates: New Routes to Hydroxyethylene Dipeptide Isostere Inhibitors of HIV-1 Protease”, J. Org. Chem. (1992) 57(10): 2771-2773 (Exhibit 62). |
| Baker et al., “Synthesis of Decahydrocyclopentacylco-octene Derivatives via Intramolecular—Photocycloaddition of Δα,β Butenolides and Reductive Cleavage”, J. Chem. Soc. Chem. Comm. (1980) 23: 1011-1012 (Exhibit 63). |
| Barton et al., “Reductive Formylation of Oximes; An Approach to the Synthesis of Vinyl Isonitriles”, Tetrahedron Letters (1988) 29(27): 3343-3346 (Exhibit 64). |
| Boar et al., “A Simple Synthesis of Enamides from Ketoximes”, J. Chem. Soc. Perkins I (1975) 1237-1241 (Exhibit 65). |
| Brettle et al., “Synthesis of Enamides”, J. Chem. Soc. Perkin Trans. I, (1988) 2185-2193 (Exhibit 66). |
| Burk et al., “A Three-Step Procedure for Asymmetric Catalytic Reductive Amidation of Ketones”, J. Org. Chem. (1998), 63, 6084-6085 (Exhibit 67 ). |
| Drefahl et al., “Amino Alcohols. I. Cis- and Trans-DL-1-amino-2-hydroxytetrahydronaphthalene and Cis- and Trans-DL-1-amino-2-hydroxyindan”, Chem. Abstracts (1958) 52: 16417f (Exhibit 68). |
| Drefahl et al., “Amino Alcohols. X. Addition of Iodine Isocyanate to Unsymmetrical Olefins”, Chem. Abstracts (1960) 54: 13078f (Exhibit 69). |
| Finberg and Youdim, “Modification of Blood Pressure and Nictitating Membrane Response to Sympathetic Amines by Selective Monoamine Oxidase Inhibitors, Types A and B, in the Cat”, Brit. J. Pharmacol. (1985) 85(2): 541-546 (Exhibit 70). |
| Fuller et al., “Inhibition in vitro of Norepinephrine N-methyltransferase by 2-Aminotetralins, Analogs of Phenylethylamines with Rigid Conformation”, Biochem. Pharmacol., (1976) 26: 446-447 (Exhibit 71). |
| Ghislandi et al., “Scissione Ottica E Configurazione Dell' 1-Aminobenzociclobutene E Dell' 1-Aminoindano”, Boll. Chim. Farm. (1976) 115: 489-500 (Exhibit 72). |
| Heikkila et al., “Prevention of MPTP-Induced Neurotoxicity by AGN-1133 and AGN-1135, Selective Inhibitors of Monoamine Oxidase-B”, Eur. J. Pharmacol. (1985) 116: 313-317 (Exhibit 73). |
| Horn et al., “Steric Requirements for Catecholamine Uptake by Rat Brain Synaptosomes: Studies with Rigid Analogs of Amphetamine”, J. Pharmacol. Exp. Ther. (1972) 180: 523-530 (Exhibit 74). |
| Huebner, “1-(N-Methyl-N-propargylamino)indans and Related Compounds”, Chem. Abstracts. (1964); 61:3046a (Exhibit 75. |
| Kabins et al., “Potential Applications for Monoamine Oxidase B Inhibitors”, Dementia (1990) 1: 323-348 (Exhibit 76). |
| Kametani et al., “Studies on the Syntheses of Heterocyclic Compounds. CLIX. The Reaction of 2-Nitro-1-indanone Oxime with Formalin and Hydrochloric Acid”, Chem. Pharm. Bull. (1966) 14(12): 1408-1413 (Exhibit 77). |
| Laso et al., “A New Selective Reduction of Nitroalkenes into Enamides”, Tetrahedron Letters (1996) 37(10): 1605-1608 (Exhibit 78). |
| Martin et al., “Potential Anti-Parkinson Drugs Designed by Receptor Mapping”, J. Med. Chem. (1973) 16(2): 147-150 (Exhibit 79). |
| Martin et al., “Discriminant Analysis of the Relationship Between Physical Properties and the Inhibition of Monoamine Oxidase by Aminotetralins and Aminoindans”, J. Med. Chem. (1974) 17(4): 409-413 (Exhibit 80). |
| Mouna et al., “Enantioselective Acetylation of Primary Amines by Cylindrocarpon Radicicola”, Bioorg. & Med. Chem. Letters, (1993) 3(4): 681-684 (Exhibit 81). |
| Nakanishi et al., “Preparation of Enamides via Reductive Acylation of N-Acetoxyimino Compounds by Use of Fe3 (CO)12” Chemistry Letters (1987) 2167-2168 (Exhibit 82). |
| Oshiro et al., “Novel Cerebroprotective Agents with Central Nervous System Stimulating Activity. 1. Synthesis and Pharmacology of 1-Amino-7-hydroxyindan Derivatives”, J. Med. Che. (1991) 34(7): 2004-2013 (Exhibit 83). |
| Riederer and Youdim, “Monoamine Oxidase Activity and Monoamine Metabolism in Brains of Parkinson's Patients Treated with l-Deprenyl”, J. Neurochem. (1986) 46(5): 1359-1365 (Exhibit 84). |
| Singh et al., “Antimalarials. 7-Chloro-4-(substituted amino)quinolines”, J. Med. Chem. (1971) 14(4): 283-286 (Exhibit 85). |
| Tekes et al., “Effect of MAO Inhibitors on the Uptake and Metabolism of Dopamine in Rat and Human Brain”, Pol. J. Pharmacol. Pharm. (1988) 40: 653-658 (Exhibit 86). |
| Top et al., “N-Alkylation of Nitriles with Tricarbonylchromium Complexes of Benzyl and Related Alcohols as Synthetic Intermediates. Futher Development of the Ritter Reactions”, J.C.S. Chem. Comm. (1979) 224-225 (Exhibit 87). |
| Youdim et al., “Monamine Oxidase” in Handbook of Experimental Pharmacology, v. 90/I. |
| (Trendelenburg and Weiner, eds., Springer-Verlag, London: 1988) Chpt. 3, 119-192 (Exhibit 88). |
| Zheng et al., “Asymmetric Synthesis of α-Amino Acid Derivatives via an Electrophilic Amination of Chiral Amide Cuprates with Li t-Butyl-N-Tosyloxycarbamate”, Tetrahedron Letters (1997) 38(16): 2817-2820 (Exhibit 89). |
| Zhu et al., “Asymmetric Rh-Catalyzed Hydrogenation of Enamides with a Chiral 1,4-Bisphosphine Bearing Diphenylphosphino Groups”, J. Org. Chem. (1998) 63: 9590-9593 (Exhibit 90). |
| The Merck Index (Windholz et al., eds., Merck & Co., Inc., Rahway, NJ, 10th ed., 1983) 149, 248-249 (Exhibit 91). |
| The Merck Manual of Diagnosis and Therapy, (Berkow et al., eds., Merck Sharp & Dohme Research Laboratories, 15th ed., 1987) 1030-1033 (Exhibit 92) 1054-1055 (Exhibit 93). |
| The Parkinson Study Group, “Effect of Deprenyl on the Progression of Disability in Early Parkinson's Disease” New Eng. J. Med. (1989) 321(20): 1364-1371 (Exhibit 94) and. |
| The Parkinson Study Group, “Effects of Tocopherol and Deprenyl on the Progression of Disability in Early Parkinson's Disease” New Eng. J. Med. (1993) 328(3): 176-183 (Exhibit 95). |
Patent Grant
6737547
