Claims
- 1. A composition having synergistic antioxidant activity comprising an effective amount of a first component of a carotenoid species, and, as a second component, a tocotrienol species or derivatives thereof.
- 2. The composition of claim 1 wherein at least one of said first or second components are derived from microorganisms, plants, extracts of microorganisms or plants, or are synthetic compounds.
- 3. The composition of claim 1 wherein at least one of said first or second components is conjugated with a compound selected from the group consisting of mono- or di-saccharides, amino acids, fatty acids, sulfates, succinate, acetate and glutathione.
- 4. The composition of claim 1 additionally containing one or more members selected from the group consisting of antioxidants, vitamins, minerals proteins, fats, carbohydrates, glucosamine, chondrotin sulfate and aminosugars.
- 5. A composition having synergistic antioxidant activity comprising an effective amount of a first component of a carotenoid species selected from the group consisting of astaxanthin, alpha-carotene, beta-carotene, lutein, lycopene, zeaxanthin, phytoene, fucoxanthin, peridin and cantaxanthin; and as a second component, a tocotrienol species selected from the group consisting of tocotrienol, alpha-, beta-, gamma-, delta-tocotrienol, desmethyl-tocotrienol, didesmethyl-tocotrienol and mixtures thereof
- 6. The composition of claim 5 wherein at least one of said first or second components are derived from microorganisms, plants, extracts of microorganisms or plants, or are synthetic compounds.
- 7. The composition of claim 5 wherein at least one of said first or second components is conjugated with a compound selected from the group consisting of mono- or di-saccharides, amino acids, fatty acids, sulfates, succinate, acetate and glutathione.
- 8. The composition of claim 5 additionally containing one or more members selected from the group consisting of antioxidants, vitamins, minerals proteins, fats, carbohydrates, glucosamine, chondrotin sulfate and aminosugars.
- 9. A composition having synergistic antioxidant activity comprising an effective amount of a first component of a carotenoid species selected from the group consisting of astaxanthin, beta-carotene, lutein and lycopene; and as a second component, a tocotrienol species selected from the group of tocotrienol, alpha-, beta-, gamma-, delta-tocotrienol and mixtures thereof.
- 10. The composition of claim 9 wherein at least one of said first or second components are derived from microorganisms, plants, extracts of microorganisms or plants, or are synthetic compounds.
- 11. The composition of claim 9 wherein at least one of said first or second components is conjugated with a compound selected from the group consisting of mono- or di-saccharides, amino acids, fatty acids, sulfates, succinate, acetate and glutathione.
- 12. The composition of claim 9 additionally containing one or more members selected from the group consisting of antioxidants, vitamins, minerals proteins, fats, carbohydrates, glucosamine, chondrotin sulfate and aminosugars.
- 13. A composition having synergistic antioxidant activity comprising an effective amount of a first component of a pharmaceutical grade carotenoid species selected from the group consisting of astaxanthin, beta-carotene, lutein and lycopene; and as a second component, a pharmaceutical grade tocotrienol species selected from the group of tocotrienol, alpha-, beta-, gamma-, delta-tocotrienol and mixtures thereof.
- 14. The composition of claim 13 wherein at least one of said first or second components are derived from microorganisms, plants, extracts of microorganisms or plants, or are synthetic compounds.
- 15. The composition of claim 13 wherein at least one of said first or second components is conjugated with a compound selected from the group consisting of mono- or di-saccharides, amino acids, fatty acids, sulfates, succinate, acetate and glutathione.
- 16. The composition of claim 13 additionally containing one or more members selected from the group consisting of antioxidants, vitamins, minerals proteins, fats, carbohydrates, glucosamine, chondrotin sulfate and aminosugars.
- 17. A composition having synergistic antioxidant activity comprising an effective amount of a first component of a pharmaceutical grade carotenoid species selected from the group consisting of astaxanthin, beta-carotene, lutein and lycopene; and as a second component, a mixture of alpha- and beta-tocotrienol or a mixture of alpha-, beta-, gamma- and delta-tocotrienol.
- 18. The composition of claim 17 wherein at least one of said first or second components are derived from microorganisms, plants, extracts of microorganisms or plants, or are synthetic compounds.
- 19. The composition of claim 17 wherein at least one of said first or second components is conjugated with a compound selected from the group consisting of mono- or di-saccharides, amino acids, fatty acids, sulfates, succinate, acetate and glutathione.
- 20. The composition of claim 17 additionally containing one or more members selected from the group consisting of antioxidants, vitamins, minerals proteins, fats, carbohydrates, glucosamine, chondrotin sulfate and aminosugars.
- 21. A composition having synergistic antioxidant activity comprising an effective amount of a first component of a pharmaceutical grade carotenoid species selected from the group consisting of astaxanthin, beta-carotene, lutein and lycopene; and as a second component, a mixture of alpha-, beta-, gamma- and delta-tocotrienol.
- 22. The composition of claim 21 wherein at least one of said first or second components are derived from microorganisms, plants, extracts of microorganisms or plants, or are synthetic compounds.
- 23. The composition of claim 21 wherein at least one of said first or second components is conjugated with a compound selected from the group consisting of mono- or di-saccharides, amino acids, fatty acids, sulfates, succinate, acetate and glutathione.
- 24. The composition of claim 21 additionally containing one or more members selected from the group consisting of antioxidants, vitamins, minerals proteins, fats, carbohydrates, glucosamine, chondrotin sulfate and aminosugars.
- 25. A method for normalization and therapeutic treatment of symptoms of oxidative stress in warm blooded animals comprising administering to an animal a composition comprising an effective amount of a first component of a carotenoid species, and as a second component, a tocotrienol species and derivatives thereof; and continuing said administration until said symptoms of oxidative stress are reduced.
- 26. The method of claim 25 wherein the composition is formulated in a dosage form such that said administration provides 0.1 to 50 mg/day of a cartenoid species, and 0.1 to 1200 mg/day of a tocotrienol species.
- 27. The method of claim 25, wherein the composition is administered in an amount sufficient to maintain a serum or tissue concentration of 0.001 to 500 μM of a cartenoid species, and 0.008 to 500 μM of a tocotrienol species.
- 29. The method of claim 25 wherein the first component and the second component are administered in a sequential manner or in a substantially simultaneous manner.
- 30. A method for normalization and therapeutic treatment of symptoms of oxidative stress in warm blooded animals comprising administering to an animal a composition comprising an effective amount of a first component of a carotenoid species selected from the group consisting of astaxanthin, alpha-carotene, beta-carotene, lutein, lycopene, zeaxanthin, phytoene, fucoxanthin, peridin and cantaxanthin; and as a second component, a tocotrienol species selected from the group consisting of tocotrienol, alpha-, beta-, gamma-, delta-tocotrienol, desmethyl-tocotrienol, didesmethyl-tocotrienol and mixtures thereof; and continuing said administration until said symptoms of oxidative stress are reduced.
- 31. The method of claim 30 wherein the composition is formulated in a dosage form such that said administration provides 0.1 to 50 mg/day of a cartenoid species, and 0.1 to 1200 mg/day of a tocotrienol species.
- 32. The method of claim 30 wherein the composition is administered in an amount sufficient to maintain a serum or tissue concentration of 0.001 to 500 μM of a cartenoid species, and 0.008 to 500 μM of a tocotrienol species.
- 33. The method of claim 30 wherein the first component and the second component are administered in a sequential manner or in a substantially simultaneous manner.
- 34. A method for normalization and therapeutic treatment of symptoms of oxidative stress in warm blooded animals comprising administering to an animal a composition comprising an effective amount of a first component of a carotenoid species selected from the group consisting of astaxanthin, beta-carotene, lutein and lycopene; and as a second component, a tocotrienol species selected from the group of tocotrienol, alpha-, beta-, gamma-, delta-tocotrienol and mixtures thereof; and continuing said administration until said symptoms of oxidative stress are reduced.
- 35. The method of claim 34 wherein the composition is formulated in a dosage form such that said administration provides 0.1 to 50 mg/day of a cartenoid species, and 0.1 to 1200 mg/day of a tocotrienol species.
- 36. The method of claim 34, wherein the composition is administered in an amount sufficient to maintain a serum or tissue concentration of 0.001 to 500 μM of a cartenoid species, and 0.008 to 500 μM of a tocotrienol species.
- 37. The method of claim 34 wherein the first component and the second component are administered in a sequential manner or in a substantially simultaneous manner.
- 38. A method for normalization and therapeutic treatment of symptoms of oxidative stress in warm blooded animals comprising administering to an animal a composition comprising an effective amount of a first component of a pharmaceutical grade carotenoid species selected from the group consisting of astaxanthin, beta-carotene, lutein and lycopene; and as a second component, a pharmaceutical grade tocotrienol species selected from the group of tocotrienol, alpha-, beta-, gamma-, delta-tocotrienol and mixtures thereof; and continuing said administration until said symptoms of oxidative stress are reduced.
- 39. The method of claim 38 wherein the composition is formulated in a dosage form such that said administration provides 0.1 to 50 mg/day of a cartenoid species, and 0.1 to 1200 mg/day of a tocotrienol species.
- 40. The method of claim 38, wherein the composition is administered in an amount sufficient to maintain a serum or tissue concentration of 0.001 to 500 μM of a cartenoid species, and 0.008 to 500 μM of a tocotrienol species.
- 41. The method of claim 38 wherein the first component and the second component are administered in a sequential manner or in a substantially simultaneous manner.
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims benefit of U.S. Provisional Application Serial No. 60/240,208 filed Oct. 13, 2000.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60240208 |
Oct 2000 |
US |