Claims
- 1. A composition for inhibiting lipoxygenase activity which comprises a compound of the formula ##STR10## wherein: R' is hydrogen or lower-alkyl;
- R" is hydrogen, lower-alkyl or halo;
- R"' is hydrogen, lower-alkyl, or lower-alkoxy; and
- Alk is lower-alkyl together with one or more pharmaceutically acceptable excipients or diluents.
- 2. A composition according to claim 1, wherein R' is hydrogen.
- 3. A composition according to claim 1 wherein R"' is lower-alkoxy.
- 4. A method for inhibiting lipoxygenase activity in a mammal which comprises administering to said mammal a pharmacologically effective amount of a composition according to claim 3.
- 5. A composition in unit dosage form for inhibiting lipoxygenase activity which comprises a compound of the formula ##STR11## wherein: R' is hydrogen or lower-alkyl;
- R" is hydrogen, lower-alkyl or halo;
- R"' is hydrogen, lower-alkyl, lower-alkoxy or halo; and
- Alk is lower-alkyl together with one or more pharmaceutically acceptable excipients or diluents.
- 6. A method for inhibiting lipoxygenase activity in a mammal which comprises administering to said mammal a pharmacologically effective amount of a composition comprising a compound of the formula ##STR12## wherein: R' is hydrogen or lower-alkyl;
- R" is hydrogen, lower-alkyl or halo;
- R"' is hydrogen, lower-alkyl, lower-alkoxy or halo; and
- Alk is lower-alkyl together with one or more pharmaceutically acceptable excipients or diluents.
- 7. A method according to claim 6 wherein R' is hydrogen.
- 8. A method for treating or preventing allergic asthma in a mammal which comprises administering to said mammal an anti-asthmatically effective amount of a composition comprising a compound of the formula ##STR13## wherein: R' is hydrogen or lower-alkyl;
- R" is hydrogen, lower-alkyl or halo;
- R"' is hydrogen, lower-alkyl, lower-alkoxy or halo; and
- Alk is lower-alkyl together with one or more pharmaceutically acceptable excipients or diluents.
Parent Case Info
This application is a division of copending application Ser. No. 512,843, filed July 11, 1983, now U.S. Pat. No. 4,515,980, issued May 7, 1985.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3819637 |
Bell |
Jun 1974 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
13144 |
Jul 1980 |
EPX |
50-65528 |
Jun 1975 |
JPX |
Non-Patent Literature Citations (3)
Entry |
Kim, J. Heterocyclic Chem. 18, 287, (1981), pp. 287-291. |
Molnar et al., Helv. Chim. Acta 52, 401-408, (1969). |
Legrand et al., Bull. Soc. Chim. France 1969, 1173-82. |
Divisions (1)
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Number |
Date |
Country |
Parent |
512843 |
Jul 1983 |
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