Claims
- 1. A method for delivering a biologically active material to the respiratory tract of a patient in need of treatment comprising the steps of:a) producing an aerosol of a liquid composition using an electrohydrodynamic spraying/aerosolization means; and b) administering said aerosol to the pulmonary tract of said patient via inhalation of said aerosol; wherein said liquid composition comprises a pharmaceutically effective amount of a biologically active material and a carrier liquid in which said active material is dissolved, emulsified, or suspended; and wherein said liquid composition has the following properties: (i) a surface tension of from about 10 to about 72 milliNewtons/meter; (ii) an electrical resistivity of from about 10 to about 100,000 ohm-meters; and (iii) an electrical permittivity of from about 5 to about 500; and wherein said aerosol has a particle size of from about 0.1 to from about 10 μm in diameter.
- 2. The method according to claim 1, wherein said surface tension is from about 15 to from about 45 milliNewtons/meter, wherein said electrical resistivity is from about 50 to from about 10,000 ohm-meters, and wherein said electrical permittivity is from about 10 to 500.
- 3. The method according to claim 2 wherein said surface tension is from about 20 to from about 35 milliNewtons/meter, wherein said electrical resistivity is from about 200 to from about 2000 ohm-meters, and wherein said electrical permittivity is from about 15 to from about 50.
- 4. The method according to claim 1 wherein said carrier material is selected from the group consisting of water, an alcohol, and a perfluorocarbon or mixtures thereof.
- 5. The method according to claim 4 wherein said carrier material is a mixture of ethanol and water.
- 6. The method according to claim 4 wherein said alcohol is selected from the group consisting of ethanol or isopropanol.
- 7. The method according to claim 6 wherein said alcohol is ethanol.
- 8. The method according to claim 1 wherein said carrier liquid consists essentially of a carrier material, an aerosol properties adjusting material and a pharmaceutically acceptable excipient, wherein said aerosol properties adjusting material is selected from the group consisting of propylene glycol, polyethylene glycol, glycerol, oleic acid, medium chain triglycerides, fatty acids, soybean oil, and olive oil.
- 9. The method according to claim 8, wherein said surface tension is from about 15 to from about 45 milliNewtons/meter, wherein said electrical resistivity is from about 50 to from about 10,000 ohm-meters, and wherein said electrical permittivity is from about 10 to 500.
- 10. The method according to claim 9 wherein said surface tension is from about 20 to from about 35 milliNewtons/meter, wherein said electrical resistivity is from about 200 to from about 2000 ohm-meters, and wherein said electrical permittivity is from about 15 to from about 50.
- 11. The method according to claim 8 wherein said pharmaceutically acceptable excipient is selected from the group consisting of antioxidants, ionic agents, surfactants, preservatives, suspending agents, sweeteners, and flavoring agents.
- 12. The method according to claim 8 wherein said active material is selected from the group consisting of a drug, a vaccine, a nucleic acid, an aptamer, a gene therapy agent, an enzyme, a hormone, an antibody, a vitamin, a protein, a peptide, a polypeptide, an oligonucleotide, a cell, an antigen, an allergen, a natural surfactant, and a synthetic surfactant.
- 13. The method according to claim 12 wherein said active material is selected from the group consisting of sodium cromoglycate, albuterol sulfate, triamcinalone, doxorubicin, and paclitaxel.
- 14. The method according to claim 12 wherein said active ingredient is selected from the group consisting of a protein, a peptide and a polypeptide.
- 15. The method according to claim 8 wherein said carrier material is selected from the group consisting of water, an alcohol, and a perfluorocarbon or mixtures thereof.
- 16. The method according to claim 15 wherein said aerosol properties adjusting material is selected from the group consisting of propylene glycol, polyethylene glycol, glycerol, oleic acid, medium chain triglycerides, fatty acids, soybean oil, and olive oil.
- 17. The method according to claim 16 wherein said aerosol properties adjusting material is selected from the group consisting of propylene glycol, polyethylene glycol and glycerol.
- 18. The method according to claim 17 wherein said carrier material is ethanol.
Parent Case Info
This patent application claims the benefit of U.S. Provisional Patent Application No. 60/132,215, filed May 3, 1999, entitled “Therapeutic Formulations for Aerosolization and Inhalation,” the disclosure of which is incorporated as if fully rewritten herein.
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60/132215 |
May 1999 |
US |