Claims
- 1. A method of generating a submucosal fluid cushion in a subject, said method comprising injecting an amount of a methylcellulose solution into the submucosa of said subject, wherein said amount is effective to generate said submucosal fluid cushion.
- 2. The method of claim 1, wherein said methylcellulose is hydroxypropyl methylcellulose.
- 3. The method of claim 1, wherein said methylcellulose is carboxymethylcellulose.
- 4. The method of claim 1, wherein said submucosa is in the gastrointestinal tract.
- 5. The method of claim 1, wherein said subject is a mammal.
- 6. The method of claim 1, wherein said subject is a human.
- 7. The method of claim 1, wherein the concentration of said methylcellulose is from about 0.1% to 1.5%.
- 8. The method of claim 1, wherein the concentration of said methylcellulose is from about 0.3% to 1.0%.
- 9. The method of claim 1, wherein the concentration of said methylcellulose is 0.83%.
- 10. The method of claim 1, wherein said amount is from about 1 to 15 ml.
- 11. The method of claim 1, wherein said amount is from about 3 to 12 ml.
- 12. The method of claim 1, wherein said amount is from about 4 to 6 ml.
- 13. The method of claim 1, wherein said method further comprises performing endoscopic mucosal resection or gastrointestinal polypectomy.
- 14. The method of claim 1, further comprising injecting a dye or a local vasoconstrictor into the submucosa of said subject.
- 15. The method of claim 14, wherein said dye is methylene blue or indigo carmine.
- 16. The method of claim 14, wherein said local vasoconstrictor is epinephrine.
- 17. The method of claim 14, wherein said methylcellulose and said dye or said local vasoconstrictor are injected simultaneously into the submucosa of said subject.
- 18. The method of claim 1, further comprising injecting a dye and a local vasoconstrictor into the submucosa of said subject.
- 19. The method of claim 18, wherein said dye and said local vasoconstrictor are injected together with said methylcellulose.
- 20. A composition comprising a methylcellulose and a local vasoconstrictor.
- 21. The composition of claim 20, wherein said methylcellulose is hydroxypropyl methylcellulose.
- 22. A composition comprising a methylcellulose and a dye.
- 23. The composition of claim 22, wherein said methylcellulose is hydroxypropyl methylcellulose.
- 24. A composition comprising a methylcellulose, a local vasoconstrictor, and a dye.
- 25. The composition of claim 24, wherein said methylcellulose is hydroxypropyl methylcellulose.
- 26. An article of manufacture comprising:
(a) a syringe containing a methylcellulose solution; and (b) instructions for using said methylcellulose solution to generate a submucosal fluid cushion in a subject.
- 27. The article of manufacture of claim 26, wherein said methylcellulose is hydroxypropyl methylcellulose.
- 28. The article of manufacture of claim 26, wherein said syringe further contains a dye.
- 29. The article of manufacture of claim 26, wherein said syringe further contains a local vasoconstrictor.
- 30. The article of manufacture of claim 26, wherein said syringe further contains a dye and a local vasoconstrictor.
- 31. The article of manufacture of claim 26, wherein said syringe contains between about 2 and about 20 ml of said methylcellulose solution.
- 32. The article of manufacture of claim 26, further comprising a plurality of syringes, wherein each said syringe in said plurality contains said methylcellulose solution.
- 33. A method of performing endoscopic mucosal resection or colonic polypectomy on a subject having a mucosal abnormality, said method comprising:
(a) generating a submucosal fluid cushion in said subject by injecting a methylcellulose solution into the submucosa of said subject; and (b) resecting said mucosal abnormality.
- 34. The method of claim 33, wherein said methylcellulose is hydroxypropyl methylcellulose.
- 35. Use of methylcellulose in the manufacture of a medicament for creating a submucosal fluid cushion in a subject.
- 36. The use of claim 35, wherein said methylcellulose is hydroxypropyl methylcellulose.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority from U.S. Provisional Application Serial No. 60/360,700, filed Feb. 28, 2002.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60360700 |
Feb 2002 |
US |