Claims
- 1. A composition comprising a water-soluble aluminum compound, a chelating agent, tannic acid and sodium hydrogen sulfite, said water-soluble aluminum being contained in a concentration ranging from 0.01 mole to 0.5 mole, said tannic acid being contained at a rate of 0.01% to 25.0% with respect to said water-soluble aluminum compound, said chelating agent being contained at a rate of from 10% to 80% with respect to said water-soluble aluminum compound, and said sodium hydrogen sulfite being contained at a rate of from 50% to 200% with respect to the amount of said tannic acid, wherein a pH of said composition ranges from pH 1.0 to pH 3.5.
- 2. A composition as claimed in claim 1, further comprising a polyvalent alcohol or a saccharide.
- 3. A composition as claimed in claim 2, wherein said polyvalent alcohol or said saccharide is mannitol, fructose, xylitol, glucose, galactose, mannose, lactose or glycerin.
- 4. A composition as claimed in 2, wherein said polyvalent alcohol or said saccharide is contained at a rate of from 3% to 20%.
- 5. A composition as claimed in claim 1, wherein said water-soluble aluminum compound is aluminum chloride, aluminum sulfate, aluminum carbonate aluminum acetate, aluminum nitrate, aluminum lactate, aluminum tartrate, aluminum salicylate, aluminum sodium sulfate, aluminum potassium sulfate, aluminum cesium sulfate or aluminum ammonium sulfate.
- 6. A composition as claimed in claim 1, wherein said water-soluble aluminum compound is contained at a rate of from 0.03 mole to 0.3 mole.
- 7. A composition as claimed in claim 1, wherein said water-soluble aluminum compound is contained at a rate of from 1% to 10% as an effective concentration in said composition.
- 8. A composition as claimed in claim 1, wherein said tannic acid is contained at a rate of from 0.01% to 10.0% as an effective concentration in said composition.
- 9. A composition as claimed in claim 8, wherein said tannic acid is contained at a rate of from 0.01% to 2.0% as an effective concentration in said composition.
- 10. A composition as claimed in claim 8, wherein said tannic acid is contained at a rate of from 0.05% to 10.0% as an effective concentration in said composition.
- 11. A composition as claimed in claim 1, wherein said tannic acid is contained at a rate of from 1% to 20% with respect to said water-soluble aluminum compound.
- 12. A composition as claimed in claim 1, wherein said chelating agent is citric acid or a salt thereof.
- 13. A composition as claimed in claim 1, wherein said chelating agent is contained at a rate of from 10% to 80% with respect to the amount of said water-soluble aluminum compound.
- 14. A composition as claimed in claim 1, wherein said chelating agent is contained at a rate of from 0.1% to 5%.
- 15. A composition as claimed in claim 1, wherein said sodium hydrogen sulfite is contained at a rate of 0.05% to 0.5%.
- 16. A composition as claimed in claim 15, wherein said sodium hydrogen sulfite is contained at a rate of 0.1% to 0.3%.
- 17. A composition as claimed in claim 1, wherein said sodium hydrogen sulfite is contained at a rate of from 70% to 150% with respect to the amount of said tannic acid.
- 18. A composition as claimed in claim 1, wherein said pH range is set to be from pH 2.0 to pH 3.0.
- 19. A method for the preparation of a composition comprising a water-soluble aluminum compound, a chelating agent, tannic acid, and sodium hydrogen sulfite as well as having a pH range of from pH 1 to pH 3.5, wherein tannic acid is mixed with a mixture prepared by formulating said water-soluble aluminum compound, said chelating agent, and said sodium hydrogen sulfite in any desired order.
- 20. A method for the preparation of the composition as claimed in claim 19, wherein a polyvalent alcohol or a saccharide is further contained in the composition.
- 21. A method for the preparation of the composition as claimed in claim 19, wherein each of the components constituting said composition is formulated under an inert atmosphere.
- 22. A method for the preparation of the composition as claimed in claim 19, wherein said composition is filled under an inert atmosphere in a container for injection or a container for storing said composition.
- 23. A method for the preparation of the composition as claimed in claim 19, wherein a pH range of said composition is from pH 2.0 to pH 3.0.
- 24. A method for the preparation of the composition as claimed in claim 19, wherein said composition is adjusted as needed to said pH range after all of said components constituting said composition have been formulated.
- 25. A method for the preparation of the composition as claimed in claim 19, wherein oxygen exists in atmosphere or in water to be used in no substantial amount or at such a restricted amount as failing to adversely affect said composition.
- 26. A method for the preparation of a composition as claimed in claim 19, wherein said composition comprises a water-soluble aluminum compound, a chelating agent, tannic acid and sodium hydrogen sulfite, said water-soluble aluminum being contained in a concentration ranging from 0.01 mole to 0.5 mole, said tannic acid being contained at a rate of 0.01% to 25.0% with respect to said water-soluble aluminum compound, said chelating agent being contained at a rate of from 10% to 80% with respect to said water-soluble aluminum compound, and sodium hydrogen sulfite being contained at a rate of from 50% to 200% with respect to the amount of said tannic acid, wherein a pH of said composition ranges from pH 1.0 to pH 3.5.
- 27. A method for the preparation of a composition comprising a water-soluble aluminum compound, a chelating agent, tannic acid and sodium hydrogen sulfite as well as having a pH range of from pH 1 to pH 3.5, wherein tannic acid and sodium hydrogen sulfite or a mixture of said tannic acid with said sodium hydrogen sulfite are or is mixed with a mixture prepared by formulating said water-soluble aluminum compound with said chelating agent.
- 28. A method for the preparation of a composition comprising a water-soluble aluminum compound, a chelating agent, tannic acid and sodium hydrogen sulfite, as well as having a pH range of from pH 1 to pH 3.5;
- wherein a first formulation is yielded by mixing said water-soluble aluminum compound with said chelating agent;
- wherein separately from said first formulation, a second formulation is yielded by mixing tannic acid with sodium hydrogen sulfite; and
- wherein said first formulations is mixed with said second formulation.
- 29. A method for the preparation of the composition as claimed in claim 28, wherein each of said first and second formulations or either one of said first and second formulation or a mixture of the first and second formulations is adjusted, as needed, to said pH range.
- 30. A method for treating a disease caused by affected tissues of the digestive system comprising orally applying a composition to kill cells of the affected tissues, said composition comprising a water-soluble aluminum compound, a chelating agent, tannic acid, and sodium hydrogen sulfite and having a polyvalent alcohol and/or a saccharide added as needed thereto as well as having a pH range of from pH 1.0 to pH 3.5.
- 31. A method as claimed in claim 30, wherein said affected tissues comprise piles, hemorrhoids, a brain aneurysm or a hepatic tumor.
- 32. A method for treating a disease as claimed in claim 30, wherein said composition comprises a water-soluble aluminum compound, a chelating agent, tannic acid and sodium hydrogen sulfite, said water-soluble aluminum being contained in a concentration ranging from 0.01 mole to 0.5 mole, said tannic acid being contained at a rate of 0.01% to 25.0% with respect to said water-soluble aluminum compound, said chelating agent being contained at a rate of from 10% to 80% with respect to said water-soluble aluminum compound, and sodium hydrogen sulfite being contained at a rate of from 50% to 200% with respect to the amount of said tannic acid, wherein a pH of said composition ranges from pH 1.0 to pH 3.5.
- 33. A method for treating a disease caused by affected tissues of the digestive system comprising injecting a composition to kill cells of the affected tissues, said composition comprising a water-soluble aluminum compound, a chelating agent, tannic acid and sodium hydrogen sulfite and having a polyvalent alcohol and/or a saccharide added as needed thereto, as well as having a pH range of from pH 1.0 to pH 3.5.
- 34. A composition consisting essentially of a water-soluble aluminum compound, a chelating agent, tannic acid and sodium hydrogen sulfite, said water-soluble aluminum being contained in a concentration ranging from 0.01 mole to 0.5 mole, said tannic acid being contained at a rate of 0.01% to 25.0% with respect to said water-soluble aluminum compound, said chelating agent being contained at a rate of from 10% to 80% with respect to said water-soluble aluminum compound, and sodium hydrogen sulfite being contained at a rate of from 50% to 200% with respect to the amount of said tannic acid, wherein a pH of said comparison ranges from pH 1.0 to pH 3.5.
Priority Claims (3)
Number |
Date |
Country |
Kind |
4-275132 |
Sep 1992 |
JPX |
|
5-288323 |
Nov 1993 |
JPX |
|
6-192219 |
Jul 1994 |
JPX |
|
Parent Case Info
This is a continuation in part of U.S. Ser. No. 08/411,704 filed May 15, 1995, abandoned, which is the national stage application of PCT/JP93/01347 filed Sep. 20, 1993, and U.S. Ser. No. 08/424,523 filed May 26, 1995, abandoned, which is the national stage application of PCT/JP94/01942 filed Nov. 17, 1994.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5252344 |
Shi |
Oct 1993 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
4-225920 |
Aug 1992 |
JPX |
94-06443 |
Mar 1994 |
WOX |
Non-Patent Literature Citations (2)
Entry |
"Aluminum Potassium Sulfate", Commentary on Pharmacopedia Japonica, 12th Revision, 1991, pp. D-1019-1021, with translation. |
Yuan, et al., "Experimental Study of Xiaozhiling injection", Journal of Traditional Chinese Medicine, vol. 1, No. 2, 1981, pp. 87 and 116. |
Related Publications (1)
|
Number |
Date |
Country |
|
424523 |
May 1995 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
411704 |
May 1995 |
|