Claims
- 1. A composition for the controlled release of GnRH or analogs thereof in mares to induce ovulation, comprising:
- (a) a non-polymeric, non-water soluble liquid carrier material having a viscosity of at least 5,000 cP at 37.degree. C. that does not crystallize neat under ambient or physiological conditions;
- (b) GnRH or analogs, or combination thereof.
- 2. The composition of claim 1, wherein the non-water soluble liquid carrier material is sucrose acetate isobutyrate.
- 3. The composition of claim 2, wherein the non-water soluble liquid carrier material is present in an amount from about 99.5 percent to about 10 percent by weight, relative to the total weight of the composition.
- 4. The composition of claim 3, wherein the non-water soluble liquid carrier material is present in an amount from about 95 percent to about 25 percent by weight, relative to the total weight of the composition.
- 5. The composition of claim 2, wherein the composition further comprises a solvent in which the non-water soluble liquid carrier is soluble.
- 6. The composition of claim 5, wherein the solvent is selected from the group consisting of ethanol, dimethylsulfoxide, ethyl lactate, ethyl acetate, benzyl alcohol, triacetin, N-methylpyrrolidone, propylene carbonate, and glycofurol.
- 7. The composition of claim 6, wherein the solvent is ethanol.
- 8. The composition of claim 5, wherein the solvent is present in an amount from about 10 to about 50 percent by weight, relative to the weight of the composition.
- 9. The composition of claim 1, wherein the analog is deslorelin.
- 10. The composition of claim 1, wherein the analog is selected from deslorelin, avorelin, leuprolide, and natural LHRH.
- 11. A liquid composition for the controlled release of GnRH or analogs thereof in mares to induce ovulation, comprising sucrose acetate isobutyrate and ethanol in a weight ratio of between about 75:25 and about 60:40, and GnRH or analog thereof or combination thereof in a concentration of between about 0.1 to about 5.0 mg/ml of liquid composition, to provide a dose of between about 0.3 mg and about 10 mg of GnRH or analog thereof or combination thereof.
- 12. A liquid composition for the controlled release of GnRH or analogs thereof in mares to induce ovulation, comprising sucrose acetate isobutyrate and ethanol in a weight ratio of between about 75:25 and about 60:40, and GnRH or analog thereof or combination thereof in a concentration of between about 1.0 to about 2.5 mg/ml of liquid composition, to deliver a dose of between about 0.3 mg and about 10 mg of GnRH or analog thereof or combination thereof.
- 13. The liquid composition of claim 11, wherein the analog of GnRH is Deslorelin.
- 14. The liquid composition of claim 12, wherein the analog of GnRH is Deslorelin.
- 15. The liquid composition of claim 11, said composition sterilized before administration to mares.
- 16. The liquid composition of claim 12, said composition sterilized before administration to mares.
- 17. The liquid composition of any of claim 11, said composition filter sterilized before administration to mares.
- 18. The liquid composition of any of claim 12, said composition filter sterilized before administration to mares.
- 19. A filter sterilized liquid composition for the controlled release of Deslorelin in mares to induce ovulation, comprising sucrose acetate isobutyrate and ethanol in a weight to weight ratio of about 75:25, and Deslorelin at a concentration of between about 0.1 and about 5.0 mg/ml of liquid composition, to deliver a dose between about 1 mg and about 2 mg of deslorelin, said composition administrable by injection.
- 20. A filter sterilized liquid composition for the controlled release of Deslorelin in mares to induce ovulation, comprising sucrose acetate isobutyrate and ethanol in a weight to weight ratio of about 75:25, and Deslorelin at a concentration of between about 1.0 and about 2.5 mg/ml of liquid composition, to deliver a dose between about 1 mg and about 2 mg of deslorelin, said composition administrable by injection.
Parent Case Info
This application claims priority to U.S. Provisional Application No. 60/047,789 filed on May 28, 1997 now abandoned.
US Referenced Citations (14)
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 9118016 |
Nov 1991 |
WOX |