Claims
- 1. A storage-stable toothpaste, which consists essentially of at least about 4% of a water soluble alkali metal tripolyphosphate salt, from 0.05 to 1.0% by weight of a substantially water insoluble non-cationic anti-bacterial agent, a phosphatase enzyme inhibitor consisting of a fluoride ion source in an amount sufficient to supply about 25 ppm to about 3500 ppm of fluoride, from about 5 to about 60% by weight of a dental abrasive, and an orally acceptable vehicle, the composition having a pH of from about 8 to about 10.
- 2. A toothpaste as claimed in claim 1 in which the noncationic anti-bacterial agent is present in from 0.01 to 2.0% by weight of the composition.
- 3. A toothpaste as claimed in claim 1 in which the noncationic anti-bacterial agent is selected from the group consisting of diphenyl ether of the formula (I): ##STR2## in which R.sup.1 is oxygen, sulphur, or an alkylene group of from one to six carbon atoms and each of R.sup.2 to R.sup.6 and R.sup.12 to R.sup.16 is hydrogen, hydroxyl or a halogen; a phenolic or bisphenolic compound; a benzoate ester and a halogenated carbanilide.
- 4. A toothpaste as claimed in claim 3 in which the compound of formula (I) is selected from the group consisting of 5,5'-dichloro-2,2'-dihydroxydiphenylmethane; 2,2'-dihydroxy-3,5,6,3',5',6'-hexachloridiphenylmethane, 3,3'-dibromo-5,5'-dichloro-2,2'-dihydroxydiphenylether, and 2,4,4'-trichloro-2'-hydroxydiphenylether.
- 5. A toothpaste as claimed in claim 1 in which the abrasive is selected from silica, plastics particles, alumina, calcium carbonate, zinc orthophosphate or calciium pyrophosphate.
- 6. A toothpaste as claimed in claim 1 in which the abrasive is silica and the orally acceptable vehicle comprises a thickening silica.
- 7. A toothpaste as claimed in claim 1 in which the alkali metal tripolyphosphate salt is sodium or potassium tripolyphosphate.
- 8. A toothpaste as claimed in claim 1 in which the alkali metal tripolyphosphate salt is present in from about 4 to about 6% by weight of the composition.
- 9. A toothpaste as claimed in claim 1 in which the pH of the composition is from about 8 to about 9.
- 10. A toothpaste as claimed in claim 1 in which the the fluoride ion source is an alkali metal fluoride.
- 11. A toothpaste as claimed in claim 10 in which the alkali metal fluoride is sodium fluoride.
- 12. A toothpaste as claimed in claim 1 in which the orally acceptable vehicle comprises a humectant system which consists of glycerin, sorbitol and polyethylene glycol.
- 13. A toothpaste as claimed in claim 1 in the form of a striped toothpaste.
- 14. A method of inhibiting of dental calculus which method comprises applying an anti-calculus effective amount of a toothpaste as defined in claim 1 to the oral cavity.
- 15. A method of inhibiting dental calculus and dental plaque which method comprises applying an anti-calculus and anti-plaque effective amount of a toothpaste as defined in claim 1 to the oral cavity.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9007074 |
Mar 1990 |
GBX |
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Parent Case Info
This application is a continuation-in-part of our co-pending application Ser. No. 407,336, filed Sep. 14, 1989, now U.S. Pat. No. 4,985,236 which is a continuation-in-part of our co-pending application Ser. No. 348,805, filed May 8, 1989, now U.S. Pat. No. 4,923,684, issued May 8, 1990, both of which applications are incorporated herein by reference thereto.
US Referenced Citations (32)
Foreign Referenced Citations (10)
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236290 |
Aug 1987 |
EPX |
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Jan 1988 |
EPX |
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Dec 1988 |
EPX |
61-36211 |
Mar 1986 |
JPX |
59-001409 |
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JPX |
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JPX |
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GBX |
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Non-Patent Literature Citations (1)
Entry |
Briner et al Calc. Tiss. Res. 11 pp. 10-22 (1973). |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
407336 |
Sep 1989 |
|
Parent |
348805 |
May 1989 |
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