COMPOUND BASED ON QUINAZOLINE-SUBSTITUTED GLUTARIMIDE SKELETON AND USE THEREOF

Abstract

The present disclosure provides a compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, or polymorphs thereof, and uses thereof. The present disclosure also provides pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, or polymorphs thereof, and uses thereof. The series of compounds designed and synthesized in the present disclosure can effectively prevent and/or treat diseases or disorders associated with the cereblon protein.

Description

TECHNICAL FIELD

The present disclosure relates to a compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof, and uses thereof, especially their use in the prevention and/or treatment of diseases or disorders associated with cereblon protein (CRBN).

BACKGROUND

Although Thalidomide, lenalidomide and other phthalimide immunomodulatory drugs (IMiDs) have shown significant efficacy in the treatment of multiple myeloma and autoimmune diseases, it was not until 2010 that the E3 ubiquitin ligase cereblon (CRBN) was identified as a direct target of IMiDs.

Subsequent research confirmed that these drugs function as molecular glue, inducing the interaction between transcription factors IKZF1/3 and CRBN protein, ultimately leading to their ubiquitination and degradation. Compared with traditional small molecule inhibitors, molecular glue protein degraders have natural mechanism advantages: the former works by occupying the functional domain of the target protein for a long time to inhibit its function, while the protein degraders directly degrade and eliminate the entire target protein, often having a much greater efficacy than traditional small molecule inhibitors. The protein degraders can target “non-drugable” targets, and have low requirements for binding force, catalytic capacity, and low concentration, which can overcome the clinical drug resistance problem of traditional small molecules. Moreover, molecular glue degraders usually have small molecular weights and desirable druggability, so the research and development of such drugs have received great attention. Based on the CRBN E3 ubiquitin ligase and molecular glue degradation mechanism, a series of compounds have been developed, such as pomalidomide, which has been launched, and CC-122 of Bristol-Myers Squibb (BMS), which is undergoing clinical trials, CC-220, CC-90009, CC-99282 and CC-92480, DKY709 from Novartis, and CFT7455 from C4 Therapeutics. The degradation substrates of these molecular glue have also expanded from the transcription factors IKZF1/3 initially discovered to include casein kinase 1α (CK1α), zinc finger protein 91 (ZFP91), and translation factor GSPT1. The degradation of these protein substrates will enable the molecular glues to exert immune regulatory, anti-inflammatory, and anti-tumor pharmaceutical activities. Currently, the number of discovered candidate compounds for molecular glue is very limited, and there are theoretically a wide variety of pathogenic proteins that can be used as degradation substrates for the development of molecular glue. Therefore, it is necessary to design and develop more molecular glue through rationalization and diversification to degrade and eliminate more pathogenic proteins and apply them to the treatment of diseases associated with these pathogenic proteins.

The compounds listed above all contain the phthalimidyl backbone shared by thalidomide-type IMiDs. Another novel molecular glue, Avadomide (CC-122), developed by Bristol Myers Squibb (BMS), exhibits significant structural differences and remarkable pharmacological effects. Avadomide can bind to CRBN, leading to more pronounced degradation of IKZF1 and IKZF3, thereby downregulating cytokines such as TNF-α and exhibiting antitumor and immunomodulatory activities. Currently, Avadomide has entered Phase II clinical trials to test its therapeutic effects on various related tumors (NCT02406742, NCT02859324, NCT03834623). Based on the quinazolinyl-substituted glutarimide backbone of Avadomide, the present invention aims to develop more novel, highly effective, low-toxicity, stable, and cost-effective molecular glue degraders through rational design to meet the demands of clinical applications.

SUMMARY OF INVENTION

In view of the above, the objectives of the present disclosure are to provide novel molecular glue protein degraders, their applications and usage methods.

To achieve the above objectives and other related goals, in one aspect, the present disclosure provides a compound of Formula (I):

or a salt, stereoisomer (including enantiomer, diastereoisomer), isotopically enriched analog, solvate, prodrug, or polymorph thereof,

• • wherein R_c1 represents H or C_1-3 alkyl, and R_c2, R_c3, R_c4, R_c5 and R_c6 are the same or different and each independently represent H, D or C_1-3 alkyl;
  • (R_1a)_n indicates that quinazoline ring of Formula (I) is optionally substituted with n R_1a, wherein R_1a represents halogen, and n represents an integer of 0, 1, 2, or 3; and
  • R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • • wherein X₁ represents optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, or optionally substituted heteroarylene;
    • L₁ represents optionally substituted linear or branched C_1-60 alkylene, or optionally substituted linear or branched C_2-60alkylene with one or more groups R_d1 and/or one or more groups R_d2 and/or any combination of one or more groups R_d1 and R_d2 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R_d1, R_d2, or a combination of R_d1 and R_d2; wherein each R_d1 is independently selected from the group consisting of O, S, N(R_d3), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, where R_d3 represents H or C_1-3 alkyl, and in case that two or more groups R_d1 are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R_d1 are not directly connected to each other; and wherein each R_d2 is independently selected from the group consisting of optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, optionally substituted heteroarylene, alkenylene, alkynylene, or any combination thereof;
    • X₂ represents a bond; and
    • R_a1 represents NR_d4R_d5, C(O)NR_d6R_d7, NHC(O)R_d8, NHC(O)NR_d9R_d10, C(O)OR_d11, OC(O)R_d12, OR_d13, SR_d14, C(O)R_d15, C(S)R_d16, S(O)R_d17, S(O)₂R_d18, S(O)₂NHR_d19, NHS(O)₂R_d20, S(O)₂OR_d21, OS(O)₂R_d22, optionally substituted linear or branched C_1-10 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl or optionally substituted heteroaryl, wherein R_d4, R_d5, R_d6, R_d7, R_d9, R_d10, R_d11, R_d13, R_d14, R_d19 and R_d21 each independently represent H, optionally substituted linear or branched C_1-10 alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted heteroaryl, and R_d8, R_d12, R_d15, R_d16, R_d17, R_d18, R_d20 and R_d22 represents optionally substituted linear or branched C_1-10 alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl or optionally substituted heteroaryl;
    • or
    • X₁ represents N(R_e1), O, S, alkynylene, alkenylene, optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, or optionally substituted heteroarylene, wherein R_e1 represents H or C_1-3 alkyl, or X₁ represents a bond;
    • L₁ represents optionally substituted linear or branched C_1-60 alkylene, or optionally substituted linear or branched C_2-60alkylene with one or more groups R_e2 and/or one or more groups R_e3 and/or any combination of one or more groups R_e2 and R_e3 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R_e2, R_e3, or a combination of R_e2 and R_e3; wherein each R_e2 is independently selected from the group consisting of O, S, N(R_e4), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH, or NHS(O)₂, wherein R_e4 represents H or C_1-3 alkyl, and in case that two or more groups R_e2 are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R_e2 are not directly connected to each other; and wherein each R_e3 is independently selected from the group consisting of optionally substituted cycloalkylene, optionally substituted heterocyclylene, optionally substituted arylene, optionally substituted heteroarylene, alkenylene, alkynylene, or any combination thereof;
    • X₂ represents C(O), S(O) or S(O)₂, or X₂ represents a bond;
    • R_a1 represents the following formula:

• • • • wherein R_f1 represents:

—NCH₂CH₂N—;

• • • •  wherein symbol * indicates the point of attachment to X₂, R_g1 represents H or C_1-3 alkyl, ring A represents cycloalkylene or heterocyclylene, and (R_g2)_n1 indicates that ring A is optionally substituted with n1 R_g2 groups, wherein n1 represents an integer of 0 to 8, and each R_g2, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;

• • • •  wherein symbol ** indicates the point of attachment to X₂, R_g3 represents H or C_1-3 alkyl, ring B represents cycloalkylene or heterocyclylene, (R_g4)_n2 indicates that ring B is optionally substituted with n2 R_g4, wherein n2 represents an integer of 0 to 8, and each R_g4, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof; or

• • • •  wherein ring C represents cycloalkylene or heterocyclylene, (R_g5)_n3 indicates that ring C is optionally substituted with n3 R_g5 groups, wherein n3 represents an integer of 0 to 8, and each R_g5, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;
      • R_f2 represents H, halogen, C_1-3 alkyl or halogenated C_1-3 alkyl
      • R_f3 represents H, halogen, C_1-3 alkyl, halogenated C_1-3 alkyl,

wherein ring D represents cycloalkylene, heterocyclylene, arylene or heteroarylene, (R_g6)_n4 indicates that ring D is optionally substituted with n4 R_g6 groups, wherein n4 represents an integer of 0 to 8, and each R_g6, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;

• • • • R_f4 represents

wherein symbol *** indicates the point of attachment to R_f5, ring E represents cycloalkylene, heterocyclylene, arylene or heteroarylene, (R_g7)_n5 indicates that ring E is optionally substituted with n5 R_g7, wherein n5 represents an integer of 0 to 8, and each R_g7, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6-cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof; and

• • • • R_f5 represents H, halogen, C_1-3 alkyl, halogenated C_1-3 alkyl,

wherein ring F represents cycloalkyl, heterocyclyl, aryl or heteroaryl, (R_g5)_n6 indicates that ring F is optionally substituted with n6 R_g5, wherein n6 represents an integer of 0 to 8, and each R_g5, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;

• • • or
    • X₁ represents N(R₁), O, S, alkynylene, or alkenylene, wherein R₁ represents H or C_1-3 alkyl, or X₁ represents a bond;
    • L₁ represents optionally substituted linear or branched C_1-60 alkylene;
    • X₂ represents N(R₂), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH—, —NH— triazolylene, or optionally substituted phenylene, wherein R₂ represents H or C_1-3 alkyl, or X₂ represents a bond; and
    • R_a1 represents hydroxy, optionally substituted adamantanyl, optionally substituted noradamantanyl, optionally substituted cubanyl, optionally substituted spirocycloalkyl, optionally substituted bicyclo[2.2.2]octan-1-yl, optionally substituted bicyclo[2.2.2]octan-2-yl, optionally substituted bornyl, optionally substituted bicyclo[2.2.1]heptanyl, optionally substituted bicyclo[2.2.1]heptenyl, optionally substituted p-menthanyl or optionally substituted m-menthanyl, wherein when R_a1 represents hydroxy, X₂ represents a bond;
    • or
    • X₁ represents N(R₃), O or S, wherein R₃ represents H or C_1-3 alkyl;
    • L₁ represents optionally substituted linear or branched C_4-60 alkylene;
    • X₂ represents N(R₄), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, or OS(O)₂, wherein R₄ represents H or C_1-3 alkyl, or X₂ represents a bond; and
    • R_a1 represents optionally substituted heterocyclyl;
    • or
    • X₁ represents alkynylene or alkenylene, or X₁ represents a bond;
    • L₁ represents optionally substituted linear or branched C_1-60 alkylene; and
    • X₂ represents N(R₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, or OS(O)₂, wherein R₅ represents H or C_1-3 alkyl, or X₂ represents a bond; and
    • R_a1 represents optionally substituted heterocyclyl;
    • or
    • X₁ represents N(R₆), O, S, alkynylene, or alkenylene, wherein R₆ represents H or C_1-3 alkyl, or X₁ represents a bond;
    • L₁ represents optionally substituted linear or branched C_2-60alkylene with one or more groups R₇ and/or one or more groups R₈ and/or any combination of one or more groups R₇ and R₈ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₇, R₈, or a combination of R₇ and R₈; wherein each R₇ is independently selected from the group consisting of O, S, N(R₉), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₉ represents H or C_1-3 alkyl, and in case that two or more groups R₇ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₇ are not directly connected to each other; and wherein each R₈ is independently selected from the group consisting of cycloalkylene, heterocyclylene, triazolylene, alkenylene, alkynylene or any combination thereof, wherein the cycloalkylene, heterocyclylene and triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
    • X₂ represents N(R₁₀), C(O)O, OC(O), C(O)NH, NHC(O), C(O), 0, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH—, —NH— triazolylene, or optionally substituted phenylene, wherein R₁₀ represents H or C_1-3 alkyl, or X₂ represents a bond; and
    • R_a1 represents hydroxy, optionally substituted heterocyclyl or optionally substituted cycloalkyl, wherein when R_a1 represents hydroxy, X₂ represents a bond;
  • or
  • R_a represents the following formula:

R_a2—X₃—,

• • • wherein X₃ represents N(R₁₁), C(O)O, OC(O), C(O)NH, NHC(O), O, S, optionally substituted cycloalkylene, optionally substituted arylene, optionally substituted heteroarylene or optionally substituted heterocyclylene, wherein R₁₁ represents H or C_1-3 alkyl, and
    • R_a2 represents optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl or optionally substituted aryl;and
  • R_b represents C_1-60 alkyl optionally substituted with D or halogen, or
  • R_b represents the following formula:

R_b1—X₄-L₂-,

• • • wherein L₂ represents optionally substituted linear or branched C_2-60 alkylene, or optionally substituted linear or branched C_2-60 alkylene with one or more groups R₁₂ and/or one or more groups R₁₃ and/or any combination of one or more groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of cycloalkylene, heterocyclylene, arylene, heteroarylene, alkenylene, alkynylene or any combination thereof, wherein the cycloalkylene, heterocyclylene, arylene and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
    • X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted cycloalkylene, optionally substituted arylene, optionally substituted heterocyclylene, optionally substituted heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, or X₄ represents a bond; and
    • R_b1 represents optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted heteroaryl;or
  • R_a represents halogen or cyano, and
  • R_b represents the following formula:

R_b2—X₅-L₃-,

• • • wherein L₃ represents optionally substituted linear or branched C_2-60 alkylene, or optionally substituted linear or branched C_2-60 alkylene with one or more groups R₁₆ and/or one or more groups R₁₇ and/or any combination of one or more groups R₁₆ and R₁₇ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₆, R₁₇, or a combination of R₁₆ and R₁₇; wherein each R₁₆ is independently selected from the group consisting of O, S, N(R₁₈), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₈ represents H or C_1-3 alkyl, and in case that two or more groups R₁₆ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₆ are not directly connected to each other; and wherein each R₁₇ is independently selected from the group consisting of cycloalkylene, heterocyclylene, arylene, heteroarylene, alkenylene, alkynylene or any combination thereof, wherein the cycloalkylene, heterocyclylene, arylene and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
    • X₅ represents N(R₁₉), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, or OS(O)₂, wherein R₁₉ represents H or C_1-3 alkyl, or X₅ represents a bond; and
    • R_b2 represents optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted heteroaryl, or represents the following formula:

• • • • wherein R_f1, R_f2, R_f3, R_f4 and R_f5 are defined as above.

In another aspect, the present disclosure provides a pharmaceutical composition comprising the compound of Formula (I) or pharmaceutically acceptable salts, stereoisomers (including enantiomers, diastereoisomer), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, and at least one pharmaceutically acceptable carrier.

In a further aspect, the present disclosure further provides a medicine kit or reagent kit comprising: the compound of Formula (I) or a pharmaceutically acceptable salt, or the pharmaceutical composition comprising the same.

In a further aspect, the present disclosure provides the compound of Formula (I) or pharmaceutically acceptable salts, enantiomers, diastereoisomer, solvates, prodrugs, or polymorphs thereof, for use as a medicament.

In a further aspect, the present disclosure provides the compound of Formula (I) or pharmaceutically acceptable salts, stereoisomers (including enantiomers, diastereoisomer), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition for use in the prevention or treatment of diseases or disorders associated with cereblon protein.

In a further aspect, the present disclosure provides use of the compound of Formula (I) or pharmaceutically acceptable salts, stereoisomers (including enantiomers, diastereoisomer), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition of the present disclosure for the manufacture of a medicament for the prevention or treatment of diseases or disorders associated with cereblon protein.

In a further aspect, the present disclosure provides a method for treating or preventing diseases or disorders associated with cereblon protein in a subject, comprising administering to the subject a therapeutically effective amount of the compound of Formula (I) or pharmaceutically acceptable salts, stereoisomers (including enantiomers, diastereoisomer), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition.

DETAILED DESCRIPTION OF THE INVENTION

The following detailed description is provided as exemplary specific embodiments to assist those skilled in the art in understanding and practicing the present disclosure. It should be appreciated, however, that such description is not intended to limit the scope of the present disclosure, and that various modifications and changes may be made to the specific embodiments described in the present disclosure without departing from the spirit and scope of the present disclosure. Such changes and modifications are to be understood as being included within the scope of the present invention as defined by the appended claims.

I. Compounds

Compounds of Formula (I)

The present disclosure provides a compound of Formula (I):

or salts (including pharmaceutically acceptable salts), stereoisomers (including enantiomers, diastereoisomer), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, wherein R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_b, (R_1a)_n, R_a, R_1a and n are as defined in the compound of Formula (I) and its various embodiments herein.

In some embodiments of the present disclosure, R_c1 represents H or C_1-3 alkyl (e.g., methyl, ethyl, or propyl).

In some embodiments of the present disclosure, R_c1 represents H.

In some embodiments of the present disclosure, R_c2, R_c3, R_c4, R_c5 and R_c6 are the same or different and each independently represent H, D or C_1-3 alkyl (e.g., methyl, ethyl, or propyl). In some sub-embodiments of the present disclosure, R_c2, R_c3, R_c4, R_c5 and R_c6 are the same or different and each independently represent H.

In some embodiments of the present disclosure, (R_1a)_n indicates that quinazoline ring of Formula (I) is optionally substituted with n R_1a, wherein R_1a represents halogen (e.g., fluorine, chlorine, bromine, or iodine), and n represents an integer of 0, 1, 2 or 3. In some sub-embodiments of the present disclosure, n represents an integer of 0.

In some embodiments of the present disclosure, the compound of Formula (I) is also of Formula (I-1):

• • wherein R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_e, (R_1a)_n, R_a, R_1a and n are as defined in the compound of Formula (I) above and its various embodiments herein;
  • wherein R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted arylene (e.g., optionally substituted C_6-10 arylene), or optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene);
  • L₁ represents:
    • optionally substituted linear or branched C_1-60 alkylene (e.g., C₁-C₄₀ alkylene, C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₈ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁ alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₅ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene), or
    • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_d1 and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_d2 and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_d1 and R_d2 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R_d1, R_d2, or a combination of R_d1 and R_d2; wherein each R_d1 is independently selected from the group consisting of O, S, N(R_d3), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, where R_d3 represents H or C_1-3 alkyl (e.g., methyl, ethyl, or propyl), and in case that two or more groups R_d1 are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R_d1 are not directly connected to each other; and wherein each R_d2 is independently selected from the group consisting of optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 5- to 15-membered heterocyclylene), optionally substituted arylene (e.g., optionally substituted C_6-10 arylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof;
  • X₂ represents a bond; and
  • R_a1 represents NR_d4R_d5, C(O)NR_d6R_d7, NHC(O)R_d8, NHC(O)NR_d9R_d10, C(O)OR_d11, OC(O)R_d12, OR_d13, SR_d14, C(O)R_d15, C(S)R_d16, S(O)R_d17, S(O)₂R_d15, S(O)₂NHR_d19, NHS(O)₂R_d20, S(O)₂OR_d21, OS(O)₂R_d22, optionally substituted linear or branched C_1-10 alkyl, optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 5- to 15-membered heterocyclyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl, or optionally substituted C_6-10 aryl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl), wherein R_d4, R_d5, R_d6, R_d7, R_d9, R_d10, R_d11, R_d13, R_d14, R_d19 and R_d21 each independently represent H, optionally substituted linear or branched C_1-10 alkyl, optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl, or optionally substituted C_6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 5- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl), and R_d8, R_d12, R_d15, R_d16, R_d17, R_d15, R_d20 and R_d22 represents optionally substituted linear or branched C_1-10 alkyl, optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 5- to 15-membered heterocyclyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl, or optionally substituted C_6-10 aryl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl);
  • and
  • R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkyl, C₁-C₂₉ alkyl, C₁-C₂₈ alkyl, C₁-C₂₇ alkyl, C₁-C₂₆ alkyl, C₁-C₂₅ alkyl, C₁-C₂₄ alkyl, C₁-C₂₃ alkyl, C₁-C₂₂ alkyl, C₁-C₂₁ alkyl, C₁-C₂₀ alkyl, C₁-C₁₉ alkyl, C₁-C₁₅ alkyl, C₁-C₁₇ alkyl, C₁-C₁₆ alkyl, C₁-C₁₅ alkyl, C₁-C₁₄ alkyl, C₁-C₁₃ alkyl, C₁-C₁₂ alkyl, C₁-C₁₁ alkyl, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₅ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, or C₁-C₂ alkyl) optionally substituted with D or halogen, or
  • R_b represents the following formula:

R_b1—X₄-L₂-,

• • • wherein L₂ represents:
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₅ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene), or
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₅ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 4- to 15-membered heterocyclylene), arylene (e.g., C_6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene, arylene and the heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
    • X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(═S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted arylene (e.g., optionally substituted C_6-20 arylene, or optionally substituted C_6-10 arylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, or X₄ represents a bond; and
    • R_b1 represents optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl, or optionally substituted C_6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 4- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl).

In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

In some embodiments of the compound of Formula (I-1), R_a represents the following formula:

R_a1—X₂-L₁-X—,

• • wherein X₁ represents optionally substituted C_3-20cycloalkylene (e.g., optionally substituted C_3-15cycloalkylene), optionally substituted 4- to 20-membered nitrogen-containing heterocyclylene (e.g., optionally substituted 4- to 15-membered nitrogen-containing heterocyclylene), optionally substituted C_6-10 arylene, or optionally substituted 5- to 20-membered heteroarylene (e.g., optionally substituted 5- to 15-membered heteroarylene);
  • L₁ represents:
    • optionally substituted linear or branched C_1-60 alkylene (e.g., C₁-C₄₀ alkylene, C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₈ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁ alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₅ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene), or
  • optionally substituted linear or branched C_2-60alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_a1 and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_d2 and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_d1 and R_d2 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R_d1, R_a2, or a combination of R_d1 and R_a2; wherein each R_d1 is independently selected from the group consisting of O, S, N(R_d3), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, where R_d3 represents H or C_1-3 alkyl, and in case that two or more groups R_d1 are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R_d1 are not directly connected to each other; and wherein each R_d2 is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_1-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH— or any combination thereof, wherein the linear or branched C_1-60 alkylene and the linear or branched C_2-60 alkylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, or any combination thereof;
  • X₂ represents a bond; and
  • R_a1 represents NR_d4R_d5, C(O)NR_d6R_d7, NHC(O)R_d8, NHC(O)NR_d9R_d10, C(O)OR_d11, OC(O)R_d12, OR_d13, SR_d14, C(O)R_d15, C(S)R_d16, S(O)R_d17, S(O)₂R_d15, S(O)₂NHR_d19, NHS(O)₂R_d20, S(O)₂OR_d21, OS(O)₂R_d22, optionally substituted linear or branched C_1-10 alkyl, optionally substituted C_3-20cycloalkyl (e.g., optionally substituted C_3-15cycloalkyl), optionally substituted 4- to 20-membered heterocyclyl (e.g., optionally substituted 5- to 15-membered heterocyclyl), optionally substituted C_6-20 aryl (e.g., optionally substituted C_6-10 aryl) or optionally substituted 5- to 20-membered heteroaryl (e.g., optionally substituted 5- to 15-membered heteroaryl), wherein R_d4, R_d5, R_d6, R_d7, R_d9, R_d10, R_d11, R_d13, R_d14, R_d19 and R_d21 are the same or different and each independently represent H, optionally substituted linear or branched C_1-10 alkyl, optionally substituted C_3-20cycloalkyl (e.g., optionally substituted C_3-15cycloalkyl), optionally substituted C_6-20 aryl (e.g., optionally substituted C_6-10 aryl), optionally substituted 4- to 20-membered heterocyclyl (e.g., optionally substituted 5- to 15-membered heterocyclyl) or optionally substituted 5- to 20-membered heteroaryl (e.g., optionally substituted 5- to 15-membered heteroaryl), and R_d8, R_d12, R_d15, R_d16, R_d17, R_d15, R_d20 and R_d22 each independently represent optionally substituted linear or branched C_1-10 alkyl, optionally substituted C_3-20cycloalkyl (e.g., optionally substituted C_3-15cycloalkyl), optionally substituted 4- to 20-membered heterocyclyl (e.g., optionally substituted 5- to 15-membered heterocyclyl), optionally substituted C_6-20 aryl (e.g., optionally substituted C_6-10 aryl) or optionally substituted 5- to 20-membered heteroaryl (e.g., optionally substituted 5- to 15-membered heteroaryl).

In some embodiments of the compound of Formula (I-1), X₁ represents:

• • optionally substituted C_3-20cycloalkylene (e.g., optionally substituted C_3-15cycloalkylene), optionally substituted 4- to 20-membered nitrogen-containing monocyclic heterocyclylene (e.g., optionally substituted 4- to 15-membered nitrogen-containing monocyclic heterocyclylene), optionally substituted 5- to 20-membered nitrogen-containing bridged heterocyclylene (e.g., optionally substituted 5- to 15-membered nitrogen-containing bridged heterocyclylene), optionally substituted 5- to 20-membered nitrogen-containing spiro-heterocyclylene (e.g., optionally substituted 5- to 15-membered nitrogen-containing spiro-heterocyclylene), optionally substituted 5- to 20-membered nitrogen-containing fused heterocyclylene (e.g., optionally substituted 5- to 15-membered nitrogen-containing fused heterocyclylene), optionally substituted C_6-10 arylene, or optionally substituted 5- to 20-membered heteroarylene (e.g., optionally substituted 5- to 15-membered heteroarylene), wherein the C_3-20cycloalkylene, the 4- to 20-membered nitrogen-containing monocyclic heterocyclylene, the 5- to 20-membered nitrogen-containing bridged heterocyclylene, the 5- to 20-membered nitrogen-containing spiro-heterocyclylene, the 5- to 20-membered nitrogen-containing fused heterocyclylene, the C_6-10 arylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

In some embodiments of the compound of Formula (I-1), R_a1 represents:

• • NR_d4R_d5, C(O)NR_d6R_d7, NHC(O)R_d8, NHC(O)NR_d9R_d10, C(O)OR_d11, OC(O)R_d12, OR_d13, SR_d14, C(O)R_d15, C(S)R_d16, S(O)R_d17, S(O)₂R_d18, S(O)₂NHR_d19, NHS(O)₂R_d20, S(O)₂OR_d21, OS(O)₂R_d22, optionally substituted linear or branched C_1-10 alkyl, optionally substituted C_3-20cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C_6-20 aryl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C_1-10 alkyl, the C_3-20cycloalkyl, the 4- to 20-membered heterocyclyl, the C_6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof;
    • wherein R_d4, R_d5, R_d6, R_d7, R_d9, R_d10, R_d11, R_d13, R_d14, R_d19 and R_d21 each independently represent H, optionally substituted linear or branched C_1-10 alkyl, optionally substituted C_3-20cycloalkyl, optionally substituted C_6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C_1-10 alkyl, the C_3-20cycloalkyl, the 4- to 20-membered heterocyclyl, the C_6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof; and
    • R_d8, R_d12, R_d15, R_d16, R_d17, R_d15, R_d20 and R_d22 each independently represent optionally substituted linear or branched C_1-10 alkyl, optionally substituted C_3-20cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C_6-20 aryl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C_1-10 alkyl, the C_3-20cycloalkyl, the 4- to 20-membered heterocyclyl, the C_6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

In some embodiments of the compound of Formula (I-1), X₁ represents:

• • cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene or bicyclo[2.2.1]heptenylene, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogenated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenylene or naphthylene, wherein the phenylene or naphthylene is optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogenated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, azepanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanylene, 3,6-diazabicyclo[3.1.1]heptanylene, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogenated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene and imidazo[2,1-b]thiazolylene, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogenated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

In some embodiments of the compound of Formula (I-1), R_a1 represents

• • NR_d4R_d5, C(O)NR_d6R_d7, NHC(O)R_d8, NHC(O)NR_d9R_d10, C(O)OR_d11, OC(O)R_d12, OR_d13, SR_d14, C(O)R_d15, C(S)R_d16, S(O)R_d17, S(O)₂R_d18, S(O)₂NHR_d19, NHS(O)₂R_d20, S(O)₂OR_d21, or OS(O)₂R_d22,
    • wherein R_d4, R_d5, R_d6, R_d7, R_d9, R_d10, R_d11, R_d13, R_d14, R_d19 and R_d21 are the same or different and each independently represent:
      • H, or
      • methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; or
      • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; or
      • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of optionally deuterated C_1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; or
      • azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof;
      • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-5cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; and
    • R_d8, R_d12, R_d15, R_d16, R_d17, R_d15, R_d20 and R_d22 each independently represent:
      • methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; or
      • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; or
      • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15 cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; or
      • azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof;
      • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof;

In some embodiments of the compound of Formula (I-1), R_a1 represents:

• • methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; or
  • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; or
  • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; or
  • azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof; or
  • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C_3-15cycloalkyl, optionally substituted C_6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

In some embodiments of the compound of Formula (I-1), X₁ represents:

wherein symbol # indicates the point of attachment to L₁.

In some embodiments of the compound of Formula (I-1), R_a1 represents hydroxy.

In some embodiments of the compound of Formula (1-1), R_a1 represents:

In some embodiments of the compound of Formula (I-1), L₁ represents the structure of the following formula:

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—(R_d1(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—(R_d1(C(R^d5)(R^a6))_m3)_p2—(R_d1(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—(R_d2(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—(R_d2(C(R^a5)(R^a6))_m3)_p2—(R_d2(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(R_d1—R_d2—(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—(R_d2(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R_d2—R_d1—(C(R^a3)(R^a4))_m2)_p1—; or

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—(R_d1(C(R^a5)(R^a6))_m3)_p2—;

• • wherein each group R_d1 is independently selected from the group consisting of O, S, N(R_d3), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R_d3 independently represents H or C_1-3 alkyl; each group R_d2 is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), optionally deuterated C_1-6 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-6 alkyl halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-6 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), optionally deuterated C_1-6 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), optionally deuterated C_1-6 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof;
  • R^a1, R^a2, R^a3, R^a4, R^a5, R^a6, R^a7 and R^a8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogenated C_1-6 alkyl halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), optionally deuterated C_1-6 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), NH₂—C_1-6 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), optionally deuterated C_1-6 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), optionally deuterated C_1-6 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof;
  • symbol ## indicates the point of attachment to X₁; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-1), L₁ represents the structure of the following formula:

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—(R_d1(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—(R_d1(C(R^d5)(R^a6))_m3)_p2—(R_d1(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—(R_d2(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—(R_d2(C(R^a5)(R^a6))_m3)_p2—(R_d2(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(R_d1—R_d2—(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—(R_d2(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R_d2—R_d1—(C(R^a3)(R^a4))_m2)_p1—; or

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—(R_d1(C(R^a5)(R^a6))_m3)_p2—;

• • wherein each R_g9 independently represents H or C_1-3 alkyl;
  • the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH—, cyano or any combination thereof;
  • R^a1, R^a2, R^a3, R^a4, R^a5, R^a6, R^a7 and R^a8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH— or any combination thereof;
  • symbol ## indicates the point of attachment to X₁; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-1), L₁ represents the following group:

• • ##—CH₂—O—CH₂—, ##—CH₂—O—(CH₂)₂—, ##—(CH₂)₁—O—(CH₂)₃—, ##—(CH₂)₁—O—(CH₂)₄—, ##—(CH₂)₁—O—(CH₂)₅—, ##—(CH₂)₁—O—(CH₂)₆—, ##—(CH₂)₁—O—(CH₂)₇—, ##—(CH₂)₁—O—(CH₂)₈—, ##—(CH₂)₁—O—(CH₂)₉—, ##—(CH₂)₁—O—(CH₂)₁₀—, ##—(CH₂)₂—O—(CH₂)₁—, ##—(CH₂)₂—O—(CH₂)₂—, ##—(CH₂)₂—O—(CH₂)₃—, ##—(CH₂)₂—O—(CH₂)₄—, ##—(CH₂)₂—O—(CH₂)₅—, ##—(CH₂)₂—O—(CH₂)₆—, ##—(CH₂)₂—O—(CH₂)₇—, ##—(CH₂)₂—O—(CH₂)₈—, ##—(CH₂)₂—O—(CH₂)₉—, ##—(CH₂)₂—O—(CH₂)₁₀—, ##—(CH₂)₂—O—(CH₂)₁₁—, ##—(CH₂)₂—O—(CH₂)₁₂—, ##—(CH₂)₃—O—(CH₂)₁—, ##—(CH₂)₃—O—(CH₂)₂—, ##—(CH₂)₃—O—(CH₂)₃—, ##—(CH₂)₃—O—(CH₂)₄—, ##—(CH₂)₃—O—(CH₂)₅—, ##—(CH₂)₃—O—(CH₂)₆—, ##—(CH₂)₃—O—(CH₂)₇—, ##—(CH₂)₄—O—(CH₂)₁—, ##—(CH₂)₄—O—(CH₂)₂—, ##—(CH₂)₄—O—(CH₂)₃—, ##—(CH₂)₄—O—(CH₂)₄—, ##—(CH₂)₄—O—(CH₂)₅—, ##—(CH₂)₄—O—(CH₂)₆—, ##—(CH₂)₅—O—(CH₂)₁—, ##—(CH₂)₅—O—(CH₂)₂—, ##—(CH₂)₅—O—(CH₂)₃—, ##—(CH₂)₅—O—(CH₂)₄—, ##—(CH₂)₅—O—(CH₂)₅—, ##—(CH₂)₆—O—(CH₂)₁—, ##—(CH₂)₆—O—(CH₂)₂—, ##—(CH₂)₆—O—(CH₂)₃—, ##—(CH₂)₆—O—(CH₂)₄—, ##—(CH₂)₇—O—(CH₂)₁—, ##—(CH₂)₇—O—(CH₂)₂—, ##—(CH₂)₇—O—(CH₂)₃—, ##—(CH₂)₈—O—(CH₂)₁—, ##—(CH₂)₈—O—(CH₂)₂—, ##—CH(CH₃)—O—(CH₂)₁—, ##—CH(CH₃)—O—(CH₂)₂—, ##—CH(CH₃)—O—(CH₂)₃—, ##—CH(CH₃)—O—(CH₂)₄—, ##—CH(CH₃)—O—(CH₂)₅—, ##—CH(CH₃)—O—(CH₂)₆—, ##—CH(CH₃)—O—(CH₂)₇—, ##—CH(CH₃)—O—(CH₂)₈—, ##—CH(CH₃)—O—(CH₂)₉—, ##—CH(CH₃)—O—(CH₂)₁₀—, ##—CH₂—(O(CH₂)₂)₂—, ##—CH₂—(O(CH₂)₂)₃—, ##—CH₂—(O(CH₂)₂)₄—, ##—CH₂—(O(CH₂)₂)₅—, ##—CH₂—(O(CH₂)₂)₆—, ##—CH₂—(O(CH₂)₂)₇—, ##—CH₂—(O(CH₂)₂)₈—, ##—CH₂—(O(CH₂)₂)₉—, ##—CH₂—(O(CH₂)₂)₁₀—, ##—CH₂—(O(CH₂)₂)₁—OCH₂—, ##—CH₂—(O(CH₂)₂)₂—OCH₂—, ##—CH₂—(O(CH₂)₂)₃—OCH₂—, ##—CH₂—(O(CH₂)₂)₄—OCH₂—, ##—CH₂—(O(CH₂)₂)₅—OCH₂—, ##—CH₂—(O(CH₂)₂)₆—OCH₂—, ##—CH₂—(O(CH₂)₂)₇—OCH₂—, ##—CH₂—(O(CH₂)₂)₈—OCH₂—, ##—CH₂—(O(CH₂)₂)₉—OCH₂—, ##—CH₂—(O(CH₂)₂)₁₀—OCH₂—, ##—(CH₂)₂—(O(CH₂)₂)₂—, ##—(CH₂)₂—(O(CH₂)₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₄—, ##—(CH₂)₂—(O(CH₂)₂)₅—, ##—(CH₂)₂—(O(CH₂)₂)₆—, ##—(CH₂)₂—(O(CH₂)₂)₇—, ##—(CH₂)₂—(O(CH₂)₂)₈—, ##—(CH₂)₂—(O(CH₂)₂)₉—, ##—(CH₂)₂—(O(CH₂)₂)₁₀—, ##—(CH₂)₃—(O(CH₂)₂)₂—, ##—(CH₂)₃—(O(CH₂)₂)₃—, ##—(CH₂)₃—(O(CH₂)₂)₄—, ##—(CH₂)₃—(O(CH₂)₂)₅—, ##—(CH₂)₃—(O(CH₂)₂)₆—, ##—(CH₂)₃—(O(CH₂)₂)₇—, ##—(CH₂)₃—(O(CH₂)₂)₈—, ##—(CH₂)₃—(O(CH₂)₂)₉—, ##—(CH₂)₃—(O(CH₂)₂)₁₀—, ##—(CH₂)₄—(O(CH₂)₂)₂—, ##—(CH₂)₄—(O(CH₂)₂)₃—, ##—(CH₂)₄—(O(CH₂)₂)₄—, ##—(CH₂)₄—(O(CH₂)₂)₅—, ##—(CH₂)₄—(O(CH₂)₂)₆—, ##—(CH₂)₄—(O(CH₂)₂)₇—, ##—(CH₂)₄—(O(CH₂)₂)₈—, ##—(CH₂)₄—(O(CH₂)₂)₉—, ##—(CH₂)₄—(O(CH₂)₂)₁₀—, ##—CH₂—(O(CH₂)₃)₂—, ##—CH₂—(O(CH₂)₃)₃—, ##—CH₂—(O(CH₂)₃)₄—, ##—CH₂—(O(CH₂)₃)₅—, ##—CH₂—(O(CH₂)₃)₆—, ##—CH₂—(O(CH₂)₃)₇—, ##—CH₂—(O(CH₂)₃)₈—, ##—CH₂—(O(CH₂)₃)₉—, ##—CH₂—(O(CH₂)₃)₁₀—, ##—(CH₂)₂—(O(CH₂)₃)₂—, ##—(CH₂)₂—(O(CH₂)₃)₃—, ##—(CH₂)₂—(O(CH₂)₃)₄—, ##—(CH₂)₂—(O(CH₂)₃)₅—, ##—(CH₂)₂—(O(CH₂)₃)₆—, ##—(CH₂)₂—(O(CH₂)₃)₇—, ##—(CH₂)₂—(O(CH₂)₃)₈—, ##—(CH₂)₂—(O(CH₂)₃)₉—, ##—(CH₂)₂—(O(CH₂)₃)₁₀—, ##—(CH₂)₃—(O(CH₂)₃)₂—, ##—(CH₂)₃—(O(CH₂)₃)₃—, ##—(CH₂)₃—(O(CH₂)₃)₄—, ##—(CH₂)₃—(O(CH₂)₃)₅—, ##—(CH₂)₃—(O(CH₂)₃)₆—, ##—(CH₂)₃—(O(CH₂)₃)₇—, ##—(CH₂)₃—(O(CH₂)₃)₈—, ##—(CH₂)₃—(O(CH₂)₃)₉—, ##—(CH₂)₃—(O(CH₂)₃)₁₀—, ##—CH₂—O—(CH₂)₂—O—(CH₂)₃—, ##—CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, ##—CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, ##—CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, ##—CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, ##—CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, ##—(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, ##—(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, ##—(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, ##—(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, ##—(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, ##—(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, ##—(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, ##—(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, ##—(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, ##—(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, ##—(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, ##—CH₂—O—(CH₂)₃—O—(CH₂)₂—, ##—CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, ##—CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, ##—CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, ##—CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, ##—CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, ##—(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, ##—(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, ##—(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, ##—(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, ##—(CH₂)₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, ##—(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, ##—(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, ##—(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, ##—(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, ##—(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, ##—(CH₂)₃—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, ##—(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, ##—CH₂—O—(CH₂)₂O—CH₂—, ##—(CH₂)₂—O—(CH₂)₂O—CH₂—, ##—(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, ##—(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, ##—(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, ##—CH₂—C(O)—CH₂—, ##—CH₂—C(O)—(CH₂)₂—, ##—(CH₂)₁—C(O)—(CH₂)₃—, ##—(CH₂)₁—C(O)—(CH₂)₄—, ##—(CH₂)₁—C(O)—(CH₂)₅—, ##—(CH₂)₁—C(O)—(CH₂)₆—, ##—(CH₂)₁—C(O)—(CH₂)₇—, ##—(CH₂)₁—C(O)—(CH₂)₈—, ##—(CH₂)₁—C(O)—(CH₂)₉—, ##—(CH₂)₁—C(O)—(CH₂)₁₀—, ##—(CH₂)₂—C(O)—(CH₂)₁—, ##—(CH₂)₂—C(O)—(CH₂)₂—, ##—(CH₂)₂—C(O)—(CH₂)₃—, ##—(CH₂)₂—C(O)—(CH₂)₄—, ##—(CH₂)₂—C(O)—(CH₂)₅—, ##—(CH₂)₂—C(O)—(CH₂)₆—, ##—(CH₂)₂—C(O)—(CH₂)₇—, ##—(CH₂)₂—C(O)—(CH₂)₈—, ##—(CH₂)₂—C(O)—(CH₂)₉—, ##—(CH₂)₂—C(O)—(CH₂)₁₀—, ##—(CH₂)₂—C(O)—(CH₂)₁₁—, ##—(CH₂)₂—C(O)—(CH₂)₁₂—, ##—(CH₂)₃—C(O)—(CH₂)₁—, ##—(CH₂)₃—C(O)—(CH₂)₂—, ##—(CH₂)₃—C(O)—(CH₂)₃—, ##—(CH₂)₃—C(O)—(CH₂)₄—, ##—(CH₂)₃—C(O)—(CH₂)₅—, ##—(CH₂)₃—C(O)—(CH₂)₆—, ##—(CH₂)₃—C(O)—(CH₂)₇—, ##—(CH₂)₄—C(O)—(CH₂)₁—, ##—(CH₂)₄—C(O)—(CH₂)₂—, ##—(CH₂)₄—C(O)—(CH₂)₃—, ##—(CH₂)₄—C(O)—(CH₂)₄—, ##—(CH₂)₄—C(O)—(CH₂)₅—, ##—(CH₂)₄—C(O)—(CH₂)₆—, ##—(CH₂)₅—C(O)—(CH₂)₁—, ##—(CH₂)₅—C(O)—(CH₂)₂—, ##—(CH₂)₅—C(O)—(CH₂)₃—, ##—(CH₂)₅—C(O)—(CH₂)₄—, ##—(CH₂)₅—C(O)—(CH₂)₅—, ##—(CH₂)₆—C(O)—(CH₂)₁—, ##—(CH₂)₆—C(O)—(CH₂)₂—, ##—(CH₂)₆—C(O)—(CH₂)₃—, ##—(CH₂)₆—C(O)—(CH₂)₄—, ##—(CH₂)₇—C(O)—(CH₂)₁—, ##—(CH₂)₇—C(O)—(CH₂)₂—, ##—(CH₂)₇—C(O)—(CH₂)₃—, ##—(CH₂)₈—C(O)—(CH₂)₁—, ##—(CH₂)₈—C(O)—(CH₂)₂—, ##—CH₂—S—CH₂—, ##—CH₂—S—(CH₂)₂—, ##—(CH₂)₁—S—(CH₂)₃—, ##—(CH₂)₁—S—(CH₂)₄—, ##—(CH₂)₁—S—(CH₂)₅—, ##—(CH₂)₁—S—(CH₂)₆—, ##—(CH₂)₁—S—(CH₂)₇—, ##—(CH₂)₁—S—(CH₂)₈—, ##—(CH₂)₁—S—(CH₂)₉—, ##—(CH₂)₁—S—(CH₂)₁₀—, ##—(CH₂)₂—S—(CH₂)₁—, ##—(CH₂)₂—S—(CH₂)₂—, ##—(CH₂)₂—S—(CH₂)₃—, ##—(CH₂)₂—S—(CH₂)₄—, ##—(CH₂)₂—S—(CH₂)₅—, ##—(CH₂)₂—S—(CH₂)₆—, ##—(CH₂)₂—S—(CH₂)₇—, ##—(CH₂)₂—S—(CH₂)₈—, ##—(CH₂)₂—S—(CH₂)₉—, ##—(CH₂)₂—S—(CH₂)₁₀—, ##—(CH₂)₂—S—(CH₂)₁₁—, ##—(CH₂)₂—S—(CH₂)₁₂—, ##—(CH₂)₃—S—(CH₂)₁—, ##—(CH₂)₃—S—(CH₂)₂—, ##—(CH₂)₃—S—(CH₂)₃—, ##—(CH₂)₃—S—(CH₂)₄—, ##—(CH₂)₃—S—(CH₂)₅—, ##—(CH₂)₃—S—(CH₂)₆—, ##—(CH₂)₃—S—(CH₂)₇—, ##—(CH₂)₄—S—(CH₂)₁—, ##—(CH₂)₄—S—(CH₂)₂—, ##—(CH₂)₄—S—(CH₂)₃—, ##—(CH₂)₄—S—(CH₂)₄—, ##—(CH₂)₄—S—(CH₂)₅—, ##—(CH₂)₄—S—(CH₂)₆—, ##—(CH₂)₅—S—(CH₂)₁—, ##—(CH₂)₅—S—(CH₂)₂—, ##—(CH₂)₅—S—(CH₂)₃—, ##—(CH₂)₅—S—(CH₂)₄—, ##—(CH₂)₅—S—(CH₂)₅—, ##—(CH₂)₆—S—(CH₂)₁—, ##—(CH₂)₆—S—(CH₂)₂—, ##—(CH₂)₆—S—(CH₂)₃—, ##—(CH₂)₆—S—(CH₂)₄—, ##—(CH₂)₇—S—(CH₂)₁—, ##—(CH₂)₇—S—(CH₂)₂—, ##—(CH₂)₇—S—(CH₂)₃—, ##—(CH₂)₈—S—(CH₂)₁—, ##—(CH₂)₈—S—(CH₂)₂—, ##—CH₂—C(S)—CH₂—, ##—CH₂—C(S)—(CH₂)₂—, ##—(CH₂)₁—C(S)—(CH₂)₃—, ##—(CH₂)₁—C(S)—(CH₂)₄—, ##—(CH₂)₁—C(S)—(CH₂)₅—, ##—(CH₂)₁—C(S)—(CH₂)₆—, ##—(CH₂)₁—C(S)—(CH₂)₇—, ##—(CH₂)₁—C(S)—(CH₂)₈—, ##—(CH₂)₁—C(S)—(CH₂)₉—, ##—(CH₂)₁—C(S)—(CH₂)₁₀—, ##—(CH₂)₂—C(S)—(CH₂)₁—, ##—(CH₂)₂—C(S)—(CH₂)₂—, ##—(CH₂)₂—C(S)—(CH₂)₃—, ##—(CH₂)₂—C(S)—(CH₂)₄—, ##—(CH₂)₂—C(S)—(CH₂)₅—, ##—(CH₂)₂—C(S)—(CH₂)₆—, ##—(CH₂)₂—C(S)—(CH₂)₇—, ##—(CH₂)₂—C(S)—(CH₂)₈—, ##—(CH₂)₂—C(S)—(CH₂)₉—, ##—(CH₂)₂—C(S)—(CH₂)₁₀—, ##—(CH₂)₂—C(S)—(CH₂)₁₁—, ##—(CH₂)₂—C(S)—(CH₂)₁₂—, ##—(CH₂)₃—C(S)—(CH₂)₁—, ##—(CH₂)₃—C(S)—(CH₂)₂—, ##—(CH₂)₃—C(S)—(CH₂)₃—, ##—(CH₂)₃—C(S)—(CH₂)₄—, ##—(CH₂)₃—C(S)—(CH₂)₅—, ##—(CH₂)₃—C(S)—(CH₂)₆—, ##—(CH₂)₃—C(S)—(CH₂)₇—, ##—(CH₂)₄—C(S)—(CH₂)₁—, ##—(CH₂)₄—C(S)—(CH₂)₂—, ##—(CH₂)₄—C(S)—(CH₂)₃—, ##—(CH₂)₄—C(S)—(CH₂)₄—, ##—(CH₂)₄—C(S)—(CH₂)₅—, ##—(CH₂)₄—C(S)—(CH₂)₆—, ##—(CH₂)₅—C(S)—(CH₂)₁—, ##—(CH₂)₅—C(S)—(CH₂)₂—, ##—(CH₂)₅—C(S)—(CH₂)₃—, ##—(CH₂)₅—C(S)—(CH₂)₄—, ##—(CH₂)₅—C(S)—(CH₂)₅—, ##—(CH₂)₆—C(S)—(CH₂)₁—, ##—(CH₂)₆—C(S)—(CH₂)₂—, ##—(CH₂)₆—C(S)—(CH₂)₃—, ##—(CH₂)₆—C(S)—(CH₂)₄—, ##—(CH₂)₇—C(S)—(CH₂)₁—, ##—(CH₂)₇—C(S)—(CH₂)₂—, ##—(CH₂)₇—C(S)—(CH₂)₃—, ##—(CH₂)₈—C(S)—(CH₂)₁—, ##—(CH₂)₈—C(S)—(CH₂)₂—, ##—CH₂—C(O)O—CH₂—, ##—CH₂—C(O)O—(CH₂)₂—, ##—(CH₂)₁—C(O)O—(CH₂)₃—, ##—(CH₂)₁—C(O)O—(CH₂)₄—, ##—(CH₂)₁—C(O)O—(CH₂)₅—, ##—(CH₂)₁—C(O)O—(CH₂)₆—, ##—(CH₂)₁—C(O)O—(CH₂)₇—, ##—(CH₂)₁—C(O)O—(CH₂)₈—, ##—(CH₂)₁—C(O)O—(CH₂)₉—, ##—(CH₂)₁—C(O)O—(CH₂)₁₀—, ##—(CH₂)₂—C(O)O—(CH₂)₁—, ##—(CH₂)₂—C(O)O—(CH₂)₂—, ##—(CH₂)₂—C(O)O—(CH₂)₃—, ##—(CH₂)₂—C(O)O—(CH₂)₄—, ##—(CH₂)₂—C(O)O—(CH₂)₅—, ##—(CH₂)₂—C(O)O—(CH₂)₆—, ##—(CH₂)₂—C(O)O—(CH₂)₇—, ##—(CH₂)₂—C(O)O—(CH₂)₈—, ##—(CH₂)₂—C(O)O—(CH₂)₉—, ##—(CH₂)₂—C(O)O—(CH₂)₁₀—, ##—(CH₂)₂—C(O)O—(CH₂)₁₁—, ##—(CH₂)₂—C(O)O—(CH₂)₁₂—, ##—(CH₂)₃—C(O)O—(CH₂)₁—, ##—(CH₂)₃—C(O)O—(CH₂)₂—, ##—(CH₂)₃—C(O)O—(CH₂)₃—, ##—(CH₂)₃—C(O)O—(CH₂)₄—, ##—(CH₂)₃—C(O)O—(CH₂)₅—, ##—(CH₂)₃—C(O)O—(CH₂)₆—, ##—(CH₂)₃—C(O)O—(CH₂)₇—, ##—(CH₂)₄—C(O)O—(CH₂)₁—, ##—(CH₂)₄—C(O)O—(CH₂)₂—, ##—(CH₂)₄—C(O)O—(CH₂)₃—, ##—(CH₂)₄—C(O)O—(CH₂)₄—, ##—(CH₂)₄—C(O)O—(CH₂)₅—, ##—(CH₂)₄—C(O)O—(CH₂)₆—, ##—(CH₂)₅—C(O)O—(CH₂)₁—, ##—(CH₂)₅—C(O)O—(CH₂)₂—, ##—(CH₂)₅—C(O)O—(CH₂)₃—, ##—(CH₂)₅—C(O)O—(CH₂)₄—, ##—(CH₂)₅—C(O)O—(CH₂)₅—, ##—(CH₂)₆—C(O)O—(CH₂)₁—, ##—(CH₂)₆—C(O)O—(CH₂)₂—, ##—(CH₂)₆—C(O)O—(CH₂)₃—, ##—(CH₂)₆—C(O)O—(CH₂)₄—, ##—(CH₂)₇—C(O)O—(CH₂)₁—, ##—(CH₂)₇—C(O)O—(CH₂)₂—, ##—(CH₂)₇—C(O)O—(CH₂)₃—, ##—(CH₂)₈—C(O)O—(CH₂)₁—, ##—(CH₂)₈—C(O)O—(CH₂)₂—, ##—CH₂—OC(O)—CH₂—, ##—CH₂—OC(O)—(CH₂)₂—, ##—(CH₂)₁—OC(O)—(CH₂)₃—, ##—(CH₂)₁—OC(O)—(CH₂)₄—, ##—(CH₂)₁—OC(O)—(CH₂)₅—, ##—(CH₂)₁—OC(O)—(CH₂)₆—, ##—(CH₂)₁—OC(O)—(CH₂)₇—, ##—(CH₂)₁—OC(O)—(CH₂)₈—, ##—(CH₂)₁—OC(O)—(CH₂)₉—, ##—(CH₂)₁—OC(O)—(CH₂)₁₀—, ##—(CH₂)₂—OC(O)—(CH₂)₁—, ##—(CH₂)₂—OC(O)—(CH₂)₂—, ##—(CH₂)₂—OC(O)—(CH₂)₃—, ##—(CH₂)₂—OC(O)—(CH₂)₄—, ##—(CH₂)₂—OC(O)—(CH₂)₅—, ##—(CH₂)₂—OC(O)—(CH₂)₆—, ##—(CH₂)₂—OC(O)—(CH₂)₇—, ##—(CH₂)₂—OC(O)—(CH₂)₈—, ##—(CH₂)₂—OC(O)—(CH₂)₉—, ##—(CH₂)₂—OC(O)—(CH₂)₁₀—, ##—(CH₂)₂—OC(O)—(CH₂)₁₁—, ##—(CH₂)₂—OC(O)—(CH₂)₁₂—, ##—(CH₂)₃—OC(O)—(CH₂)₁—, ##—(CH₂)₃—OC(O)—(CH₂)₂—, ##—(CH₂)₃—OC(O)—(CH₂)₃—, ##—(CH₂)₃—OC(O)—(CH₂)₄—, ##—(CH₂)₃—OC(O)—(CH₂)₅—, ##—(CH₂)₃—OC(O)—(CH₂)₆—, ##—(CH₂)₃—OC(O)—(CH₂)₇—, ##—(CH₂)₄—OC(O)—(CH₂)₁—, ##—(CH₂)₄—OC(O)—(CH₂)₂—, ##—(CH₂)₄—OC(O)—(CH₂)₃—, ##—(CH₂)₄—OC(O)—(CH₂)₄—, ##—(CH₂)₄—OC(O)—(CH₂)₅—, ##—(CH₂)₄—OC(O)—(CH₂)₆—, ##—(CH₂)₅—OC(O)—(CH₂)₁—, ##—(CH₂)₅—OC(O)—(CH₂)₂—, ##—(CH₂)₅—OC(O)—(CH₂)₃—, ##—(CH₂)₅—OC(O)—(CH₂)₄—, ##—(CH₂)₅—OC(O)—(CH₂)₅—, ##—(CH₂)₆—OC(O)—(CH₂)₁—, ##—(CH₂)₆—OC(O)—(CH₂)₂—, ##—(CH₂)₆—OC(O)—(CH₂)₃—, ##—(CH₂)₆—OC(O)—(CH₂)₄—, ##—(CH₂)₇—OC(O)—(CH₂)₁—, ##—(CH₂)₇—OC(O)—(CH₂)₂—, ##—(CH₂)₇—OC(O)—(CH₂)₃—, ##—(CH₂)₈—OC(O)—(CH₂)₁—, ##—(CH₂)₈—OC(O)—(CH₂)₂—, ##—(CH₂)₁—N(R_g10)—(CH₂)₁—, ##—(CH₂)₁—N(R_g10)—(CH₂)₂—, ##—(CH₂)₁—N(R_g10)—(CH₂)₃—, ##—(CH₂)₁—N(R_g10)—(CH₂)₄—, ##—(CH₂)₁—N(R_g10)—(CH₂)₅—, ##—(CH₂)₁—N(R_g10)—(CH₂)₆—, ##—(CH₂)₁—N(R_g10)—(CH₂)₇—, ##—(CH₂)₁—N(R_g10)—(CH₂)₈—, ##—(CH₂)₁—N(R_g10)—(CH₂)₉—, ##—(CH₂)₁—N(R_g10)—(CH₂)₁₀—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁—, ##—(CH₂)₂—N(R_g10)—(CH₂)₂—, ##—(CH₂)₂—N(R_g10)—(CH₂)₃—, ##—(CH₂)₂—N(R_g10)—(CH₂)₄—, ##—(CH₂)₂—N(R_g10)—(CH₂)₅—, ##—(CH₂)₂—N(R_g10)—(CH₂)₆—, ##—(CH₂)₂—N(R_g10)—(CH₂)₇—, ##—(CH₂)₂—N(R_g10)—(CH₂)₈—, ##—(CH₂)₂—N(R_g10)—(CH₂)₉—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁₀—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁₁—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁₂—, ##—(CH₂)₃—N(R_g10)—(CH₂)₁—, ##—(CH₂)₃—N(R_g10)—(CH₂)₂—, ##—(CH₂)₃—N(R_g10)—(CH₂)₃—, ##—(CH₂)₄—N(R_g10)—(CH₂)₁—, ##—(CH₂)₄—N(R_g10)—(CH₂)₂—, ##—(CH₂)₄—N(R_g10)—(CH₂)₃—, ##—(CH₂)₄—N(R_g10)—(CH₂)₄—, ##—(CH₂)₅—N(R_g10)—(CH₂)₁—, ##—(CH₂)₈—N(R_g10)—(CH₂)₂—, ##—(CH₂)₈—N(R_g10)—(CH₂)₃—, ##—(CH₂)₈—N(R_g10)—(CH₂)₄—, ##—(CH₂)₈—N(R_g10)—(CH₂)₅—, ##—(CH₂)₆—N(R_g10)—(CH₂)₁—, ##—(CH₂)₆—N(R_g10)—(CH₂)₂—, ##—(CH₂)₆—N(R_g10)—(CH₂)₃—, ##—(CH₂)₇—N(R_g10)—(CH₂)₁—, ##—(CH₂)₇—N(R_g10)—(CH₂)₂—, ##—(CH₂)₇—N(R_g10)—(CH₂)₃—, ##—(CH₂)₈—N(R_g10)—(CH₂)₁—, ##—(CH₂)₈—NR_g10)—(CH₂)₂—, ##—(CH₂)₈—N(R_g10)—(CH₂)₃—, ##—CH(CH₃)—N(R_g10)—(CH₂)₁—, ##—CH(CH₃)—N(R_g10)—(CH₂)₂—, ##—CH(CH₃)—N(R_g10)—(CH₂)₃—, ##—CH(CH₃)—N(R_g10)—(CH₂)₄—, ##—CH(CH₃)—N(R_g10)—(CH₂)₅—, ##—CH(CH₃)—N(R_g10)—(CH₂)₆—, ##—CH(CH₃)—N(R_g10)—(CH₂)₇—, ##—CH(CH₃)—N(R_g10)—(CH₂)₈—, ##—CH(CH₃)—N(R_g10)—(CH₂)₉—, ##—CH(CH₃)—N(R_g10)—(CH₂)₁₀—, ##—CH₂C(O)NHCH₂—, ##—(CH₂)₂C(O)NH(CH₂)₂—, ##—(CH₂)₂C(O)NH(CH₂)₃—, ##—(CH₂)₂C(O)NH(CH₂)₄—, ##—(CH₂)₂C(O)NH(CH₂)₅—, ##—(CH₂)₃C(O)NH(CH₂)₃—, ##—(CH₂)₃C(O)NH(CH₂)₄—, ##—(CH₂)₄C(O)NH(CH₂)₄—, ##—(CH₂)₅C(O)NH(CH₂)₅—, ##—(CH₂)₆C(O)NH(CH₂)₇—, ##—(CH₂)₆C(O)NH(CH₂)₆—, ##—(CH₂)₇C(O)NH(CH₂)₇—, ##—(CH₂)₈C(O)NH(CH₂)₈, ##—(CH₂)₉C(O)NH(CH₂)₉—, ##—(CH₂)₁₀C(O)NH(CH₂)₁₀—, ##—(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, ##—CH₂NHC(O)CH₂—, ##—(CH₂)₂NHC(O)(CH₂)₂—, ##—(CH₂)₂NHC(O)(CH₂)₃—, ##—(CH₂)₂NHC(O)(CH₂)₄—, ##—(CH₂)₂NHC(O)(CH₂)₅—, ##—(CH₂)₃NHC(O)(CH₂)₃—, ##—(CH₂)₃NHC(O)(CH₂)₄—, ##—(CH₂)₄NHC(O)(CH₂)₄—, ##—(CH₂)₅NHC(O)(CH₂)₅—, ##—(CH₂)₅NHC(O)(CH₂)₇—, ##—(CH₂)₆NHC(O)(CH₂)₆—, ##—(CH₂)₇NHC(O)(CH₂)₇—, ##—(CH₂)₅NHC(O)(CH₂)₈, ##—(CH₂)₉NHC(O)(CH₂)₉—, ##—(CH₂)₁₀NHC(O)(CH₂)₁₀—, ##—(CH₂)₄NHC(O)(CH₂)₅—, ##—(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, ##—(CH₂)₄NHC(O)CH₂—, ##—CH₂-piperidinylene-CH₂—, ##—CH₂-piperidinylene-(CH₂)₂—, ##—CH₂-piperidinylene-(CH₂)₃—, ##—CH₂-piperidinylene-(CH₂)₄—, ##—CH₂-piperidinylene-(CH₂)₅—, ##—CH₂-piperidinylene-(CH₂)₆—, ##—CH₂-piperidinylene-(CH₂)₇—, ##—CH₂-piperidinylene-(CH₂)₈—, ##—(CH₂)₂-piperidinylene-(CH₂)₁—, ##—(CH₂)₂-piperidinylene-(CH₂)—, ##—(CH₂)₂-piperidinylene-(CH₂)₃—, ##—(CH₂)₂-piperidinylene-(CH₂)₄—, ##—(CH₂)₂-piperidinylene-(CH₂)₅—, ##—(CH₂)₂-piperidinylene-(CH₂)₆—, ##—(CH₂)₂-piperidinylene-(CH₂)₇—, ##—(CH₂)₂-piperidinylene-(CH₂)₈—, ##—(CH₂)₃-piperidinylene-CH₂—, ##—(CH₂)₃-piperidinylene-(CH₂)₂—, ##—(CH₂)₃-piperidinylene-(CH₂)₃—, ##—(CH₂)₃-piperidinylene-(CH₂)₄—, ##—(CH₂)₃-piperidinylene-(CH₂)₅—, ##—(CH₂)₃-piperidinylene-(CH₂)₆—, ##—(CH₂)₃-piperidinylene-(CH₂)₇—, ##—(CH₂)₃-piperidinylene-(CH₂)₈—, ##—(CH₂)₄-piperidinylene-CH₂—, ##—(CH₂)₄-piperidinylene-(CH₂)₂—, ##—(CH₂)₄-piperidinylene-(CH₂)₃—, ##—(CH₂)₄-piperidinylene-(CH₂)₄—, ##—(CH₂)₄-piperidinylene-(CH₂)₅—, ##—(CH₂)₄-piperidinylene-(CH₂)₆—, ##—(CH₂)₄-piperidinylene-(CH₂)₇—, ##—(CH)₄-piperidinylene-(CH₂)₈—, ##—(CH₂)₅-piperidinylene-(CH₂)₁—, ##—(CH₂)₅-piperidinylene-(CH₂)₂—, ##—(CH₂)₅-piperidinylene-(CH₂)₃—, ##—(CH₂)₅-piperidinylene-(CH₂)₄—, ##—(CH₂)₅-piperidinylene-(CH₂)₅—, ##—(CH₂)₅-piperidinylene-(CH₂)₆—, ##—(CH₂)₅-piperidinylene-(CH₂)₇—, ##—(CH₂)₅-piperidinylene-(CH₂)₈—, ##—(CH₂)₆-piperidinylene-(CH₂)₁—, ##—(CH₂)₆-piperidinylene-(CH₂)₂—, ##—(CH₂)₆-piperidinylene-(CH₂)₆—, ##—(CH₂)₆-piperidinylene-(CH₂)₄—, ##—(CH₂)₆-piperidinylene-(CH₂)₅—, ##—(CH₂)₆-piperidinylene-(CH₂)₆—, ##—(CH₂)₆-piperidinylene-(CH₂)₇—, ##—(CH₂)₆-piperidinylene-(CH₂)₈—, ##—(CH₂)₇-piperidinylene-(CH₂)₁—, ##—(CH₂)₇-piperidinylene-(CH₂)₂—, ##—(CH₂)₇-piperidinylene-(CH₂)₃—, ##—(CH₂)₇-piperidinylene-(CH₂)₄—, ##—(CH₂)₇-piperidinylene-(CH₂)₈—, ##—(CH₂)₈-piperidinylene-CH₂—, ##—(CH₂)₈-piperidinylene-(CH₂)₂—, ##—(CH₂)₈-piperidinylene-(CH₂)₃—, ##—(CH₂)₈-piperidinylene-(CH₂)₄—, ##—(CH₂)₈-piperidinylene-(CH₂)₅—, ##—(CH₂)₈-piperidinylene-(CH₂)₆—, ##—(CH₂)₈-piperidinylene-(CH₂)₇—, ##—(CH₂)₈-piperidinylene-(CH₂)₈—, ##—CH₂-piperazinylene-CH₂—, ##—CH₂-piperazinylene-(CH₂)₂—, ##—CH₂-piperazinylene-(CH₂)₃—, ##—CH₂-piperazinylene-(CH₂)₄—, ##—CH₂-piperazinylene-(CH₂)₅—, ##—CH₂-piperazinylene-(CH₂)₆—, ##—CH₂-piperazinylene-(CH₂)₇—, ##—CH₂-piperazinylene-(CH₂)₈—, ##—(CH₂)₂-piperazinylene-(CH₂)₁—, ##—(CH₂))-piperazinylene-(CH₂)₂—, ##—(CH₂)₂-piperazinylene-(CH₂)₃—, ##—(CH₂)₂-piperazinylene-(CH₂)₄—, ##—(CH₂)₂-piperazinylene-(CH₂)₅—, ##—(CH₂)₂-piperazinylene-(CH₂)₆—, ##—(CH₂)₂-piperazinylene-(CH₂)₇—, ##—(CH₂)₂-piperazinylene-(CH₂)₈—, ##—(CH₂)₃-piperazinylene-CH₂-##—(CH₂)₃-piperazinylene-(CH₂)₂—, ##—(CH₂)₃-piperazinylene-(CH₂)₃—, ##—(CH₂)₃-piperazinylene-(CH₂)₄—, ##—(CH₂)₃-piperazinylene-(CH₂)₅—, ##—(CH₂)₃-piperazinylene-(CH₂)₆—, ##—(CH₂)₃-piperazinylene-(CH₂)₇—, ##—(CH₂)₃-piperazinylene-(CH₂)₈—, ##—(CH₂)₄-piperazinylene-CH₂—, ##—(CH₂)₄-piperazinylene-(CH₂)₂—, ##—(CH₂)₄-piperazinylene-(CH₂)₃—, ##—(CH₂)₄-piperazinylene-(CH₂)₄—, ##—(CH₂)₄-piperazinylene-(CH₂)₅—, ##—(CH₂)₄-piperazinylene-(CH₂)₆—, ##—(CH₂)₄-piperazinylene-(CH₂)₇—, ##—(CH₂)₄-piperazinylene-(CH₂)₈—, ##—(CH₂)₅-piperazinylene-(CH₂)₁—, ##—(CH₂)₅-piperazinylene-(CH₂)₂—, ##—(CH₂)₅-piperazinylene-(CH₂)₃—, ##—(CH₂)₅-piperazinylene-(CH₂)₄—, ##—(CH₂)₅-piperazinylene-(CH₂)₅—, ##—(CH₂)₅-piperazinylene-(CH₂)₆—, ##—(CH₂)₅-piperazinylene-(CH₂)₇—, ##—(CH₂)₅-piperazinylene-(CH₂)₈—, ##—(CH₂)₆-piperazinylene-(CH₂)₁—, ##—(CH₂)₆-piperazinylene-(CH₂)₂—, ##—(CH₂)₆-piperazinylene-(CH₂)₃—, ##—(CH₂)₆-piperazinylene-(CH₂)₄—, ##—(CH₂)₆-piperazinylene-(CH₂)₅—, ##—(CH₂)₆-piperazinylene-(CH₂)₆—, ##—(CH₂)₆-piperazinylene-(CH₂)₇—, ##—(CH₂)₆-piperazinylene-(CH₂)₈—, ##—(CH₂)₇-piperazinylene-(CH₂)₁—, ##—(CH₂)₇-piperazinylene-(CH₂)₂—, ##—(CH₂)₇-piperazinylene-(CH₂)₃—, ##—(CH₂)₇-piperazinylene-(CH₂)₄—, ##—(CH₂)₇-piperazinylene-(CH₂)₈—, ##—(CH₂)₈-piperazinylene-CH₂—, ##—(CH₂)₈-piperazinylene-(CH₂)₂—, ##—(CH₂)₈-piperazinylene-(CH₂)₃—, ##—(CH₂)₈-piperazinylene-(CH₂)₄—, ##—(CH₂)₈-piperazinylene-(CH₂)₅—, ##—(CH₂)₈-piperazinylene-(CH₂)₆—, ##—(CH₂)₈-piperazinylene-(CH₂)₇—, ##—(CH₂)₈-piperazinylene-(CH₂)₈—, ##—CH₂-propylene-CH₂—, ##—CH₂-propylene-(CH₂)₂—, ##—CH₂-propylene-(CH₂)₃—, ##—CH₂-propylene-(CH₂)₄—, ##—CH₂-propylene-(CH₂)₅—, ##—CH₂-propylene-(CH₂)₆—, ##—CH₂-propylene-(CH₂)₇—, ##—CH₂-propylene-(CH₂)₈—, ##—(CH₂)₂-propylene-(CH₂)₁—, ##—(CH₂)₂-propylene-(CH₂)₂—, ##—(CH₂)₂-propylene- (CH₂)₃—, ##—(CH₂)₂-propylene-(CH₂)₄—, ##—(CH₂)₂-propylene-(CH₂)₅—, ##—(CH₂)₂-propylene-(CH₂)₆—, ##—(CH₂)₂-propylene-(CH₂)₇—, ##—(CH₂)₂-propylene-(CH₂)₈—, ##—(CH₂)₃-propylene-CH₂—, ##—(CH₂)₃-propylene-(CH₂)₂—, ##—(CH₂)₃-propylene-(CH₂)₃—, ##—(CH₂)₃-propylene-(CH₂)₄—, ##—(CH₂)₃-propylene- (CH₂)₅—, ##—(CH₂)₃-propylene-(CH₂)₆—, ##—(CH₂)₃-propylene-(CH₂)₇—, ##—(CH₂)₃-propylene-(CH₂)₈—, ##—(CH₂)₄-propylene-CH₂—, ##—(CH₂)₄-propylene-(CH₂)₂—, ##—(CH₂)₄-propylene-(CH₂)₃—, ##—(CH₂)₄-propylene-(CH₂)₄—, ##—(CH₂)₄-propylene-(CH₂)₅—, ##—(CH₂)₄-propylene-(CH₂)₆—, ##—(CH₂)₄-propylene- (CH₂)₇—, ##—(CH₂)₄-propylene-(CH₂)₈—, ##—(CH₂)₅-propylene-(CH₂)₁—, ##—(CH₂)₅-propylene-(CH₂)₂—, ##—(CH₂)₅-propylene-(CH₂)₃—, ##—(CH₂)₅-propylene-(CH₂)₄—, ##—(CH₂)₅-propylene-(CH₂)₅—, ##—(CH₂)₅-propylene-(CH₂)₆—, ##—(CH₂)₅-propylene-(CH₂)₇—, ##—(CH₂)₅-propylene-(CH₂)₈—, ##—(CH₂)₆-propylene- (CH₂)₁—, ##—(CH₂)₆-propylene-(CH₂)₂—, ##—(CH₂)₆-propylene-(CH₂)₃—, ##—(CH₂)₆-propylene-(CH₂)₄—, ##—(CH₂)₆-propylene-(CH₂)₅—, ##—(CH₂)₆-propylene-(CH₂)₆—, ##—(CH₂)₆-propylene-(CH₂)₇—, ##—(CH₂)₆-propylene-(CH₂)₈—, ##—(CH₂)₇-propylene-(CH₂)₁—, ##—(CH₂)₇-propylene-(CH₂)₂—, ##—(CH₂)₇-propylene- (CH₂)₃—, ##—(CH₂)₇-propylene-(CH₂)₄—, ##—(CH₂)₇-propylene-(CH₂)₈—, ##—(CH₂)₈-propylene-CH₂—, ##—(CH₂)₈-propylene-(CH₂)₂—, ##—(CH₂)₈-propylene-(CH₂)₃—, ##—(CH₂)₈-propylene-(CH₂)₄—, ##—(CH₂)₈-propylene-(CH₂)₅—, ##—(CH₂)₈-propylene-(CH₂)₆—, ##—(CH₂)₈-propylene-(CH₂)₇—, ##—(CH₂)₈-propylene- (CH₂)₈—, ##—CH₂-diazacycloheptanylene-CH₂—, ##—CH₂-diazacycloheptanylene-(CH₂)₂—, ##—CH₂-diazacycloheptanylene-(CH₂)₃—, ##—CH₂-diazacycloheptanylene-(CH₂)₄—, ##—CH₂-diazacycloheptanylene-(CH₂)₅—, ##—CH₂-diazacycloheptanylene-(CH₂)₆—, ##—CH₂-diazacycloheptanylene-(CH₂)₇—, ##—CH₂-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₃-diazacycloheptanylene-CH₂—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₄-diazacycloheptanylene-CH₂—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₈-diazacycloheptanylene-CH₂—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—CH₂-diazabicyclo[3.2.1]octylene-CH₂—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—CH₂-diazabicyclo[2.2.2]octylene-CH₂—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-CH₂—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₈—;
  • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • each R_g10 independently represents H or C_1-3 alkyl; and
  • symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-1), L₁ represents the following group:

wherein symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-1), L₁ represents the structure of the following formula: ##—C_1-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_1-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X₁. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

In some embodiments of the compound of Formula (I-1), L₁ represents the following group: ##—CH₂—, ##—(CH₂)₂—, ##—(CH₂)₃—, ##—(CH₂)₄—, ##—(CH₂)₅—, ##—(CH₂)₂—CF₂—(CH₂)₂—, ##—(CH₂)₆—, ##—(CH₂)₇—, ##—(CH₂)₈—, ##—(CH₂)₉—, ##—(CH₂)₁₀—, ##—(CH₂)₁₁—, ##—(CH₂)₁₂—, ##—(CH₂)₁₃—, ##—(CH₂)₁₄—, ##—(CH₂)₁₅—, ##—(CH₂)₁₆—, ##—(CH₂)₁₇—, ##—(CH₂)₁₈—, ##—(CH₂)₁₉—, ##—(CH₂)₂₀—, ##—(CH₂)₂₁—, ##—(CH₂)₂₂—, ##—(CH₂)₂₅—, or ##—(CH₂)₃₀—;

• • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X₁. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

In some embodiments of the compound of Formula (I-1), R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkyl, C₁-C₂₉ alkyl, C₁-C₂₈ alkyl, C₁-C₂₇ alkyl, C₁-C₂₆ alkyl, C₁-C₂₅ alkyl, C₁-C₂₄ alkyl, C₁-C₂₃ alkyl, C₁-C₂₂ alkyl, C₁-C₂₁ alkyl, C₁-C₂₀ alkyl, C₁-C₁₉ alkyl, C₁-C₁₈ alkyl, C₁-C₁₇ alkyl, C₁-C₁₆ alkyl, C₁-C₁₅ alkyl, C₁-C₁₄ alkyl, C₁-C₁₃ alkyl, C₁-C₁₂ alkyl, C₁-C₁₁ alkyl, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₈ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, or C₁-C₂ alkyl) optionally substituted with D or halogen.

In some embodiments of the compound of Formula (I-1), R_b represents the following group: CH₃, CF₃, CD₃, CH₂CH₃, —(CH₂)₂—CH₃, —(CH₂)₃—CH₃, —(CH₂)₄—CH₃, —(CH₂)₅—CH₃, —(CH₂)₆—CH₃, —(CH₂)₇—CH₃, —(CH₂)₈—CH₃, —(CH₂)₉—CH₃, —(CH₂)₁₀—CH₃, —(CH₂)₁₁—CH₃, —(CH₂)₁₂—CH₃, —(CH₂)₁₃—CH₃, —(CH₂)₁₄—CH₃, —(CH₂)₁₅—CH₃, —(CH₂)₁₆—CH₃, —(CH₂)₁₇—CH₃, —(CH₂)₁₈—CH₃, —(CH₂)₁₉—CH₃, —(CH₂)₂₀—CH₃, —(CH₂)₂₁—CH₃, —(CH₂)₂₂—CH₃, —(CH₂)₂₃—CH₃, —(CH₂)₂₄—CH₃, —(CH₂)₂₅—CH₃, —(CH₂)₂₆—CH₃, —(CH₂)₂₇—CH₃, —(CH₂)₂₈—CH₃, or —(CH₂)₂₉—CH₃.

In some embodiments of the compound of Formula (I-1), R_b represents the following formula:

R_b1—X₄-L₂-,

• • wherein L₂ represents:
    • linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof, or
    • optionally substituted linear or branched C_2-60alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of C_3-15cycloalkylene, 4- to 15-membered heterocyclylene, C_6-10 arylene, 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene, C_6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), cyano or any combination thereof, and the linear or branched C_2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C_1-4 alkyl (e.g., C_1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogen, C_3-6cycloalkyl or any combination thereof;
    • X₄ represents a bond, or X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted C_3-20cycloalkylene, optionally substituted C_6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, and the C_3-20cycloalkylene, the C_6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; and
    • R_b1 represents optionally substituted C_3-20cycloalkyl, optionally substituted C_6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C_3-20cycloalkyl, the C_6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl (e.g., optionally substituted cyclopropyl, optionally substituted cyclobutyl, optionally substituted cyclopentyl or optionally substituted cyclohexyl), optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; and the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

In some embodiments of the compound of Formula (I-1), L₂ represents the structure of the following formula: —C_2-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (I-1), L₂ represents the following group:

• • —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₂—CF₂—(CH₂)₂—, —(CH₂)₆—, —(CH₂)₇—, —(CH₂)₈—, —(CH₂)₉—, —(CH₂)₁₀—, —(CH₂)₁₁—, —(CH₂)₁₂—, —(CH₂)₁₃—, —(CH₂)₁₄—, —(CH₂)₁₅—, —(CH₂)₁₆—, —(CH₂)₁₇—, —(CH₂)₁₈—, —(CH₂)₁₉—, —(CH₂)₂₀—, —(CH₂)₂₁—, —(CH₂)₂₂—, —(CH₂)₂₅—, or —(CH₂)₃₀—;
  • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the group is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (I-1), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—(R₁₂(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—(R₁₃(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₂—R₁₃—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃—R₁₂—(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each group R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R₁₄ independently represents H or C_1-3 alkyl; and each group R₁₃ is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-1), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—(O(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m1)_p1—(O(C(R^a13)(R^a14)_p2—(O(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—(N(R_g11)(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—(C(O)NH—(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—C(O)NH—(C(R^a11)(R^a12))_m2—(O(C(R^a13)(R^a14))_m3)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(NHC(O)N—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13(R^a14)_m3)_p2—(O—(C(R^a15(R^a16)_m4)_p3—;

—(C(R^a9)(R^a10))_m1—C(O)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—C(S)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—S—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—C_6-10 arylene-(C(R^a13)(R^a14))_m3—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1-(4- to 15-membered heterocyclylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1-(5- to 15-membered heteroarylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C_3-15 cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(C_3-15cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—(C_3-15cycloalkylene-(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each R_g11 independently represents H or C_1-3 alkyl;
  • the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-1), L₂ represents the structure of the following formula:

• • —CH₂—O—CH₂—, —CH₂—O—(CH₂)₂—, —(CH₂)₁—O—(CH₂)₃—, —(CH₂)₁—O—(CH₂)₄—, —(CH₂)₁—O—(CH₂)₅—, —(CH₂)₁—O—(CH₂)₆—, —(CH₂)₁—O—(CH₂)₇—, —(CH₂)₁—O—(CH₂)₈—, —(CH₂)₁—O—(CH₂)₉—, —(CH₂)₁—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁—, —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—O—(CH₂)₄—, —(CH₂)₂—O—(CH₂)₅—, —(CH₂)₂—O—(CH₂)₆—, —(CH₂)₂—O—(CH₂)₇—, —(CH₂)₂—O—(CH₂)₈—, —(CH₂)₂—O—(CH₂)₉—, —(CH₂)₂—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁₁—, —(CH₂)₂—O—(CH₂)₁₂—, —(CH₂)₃—O—(CH₂)₁—, —(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—O—(CH₂)₃—, —(CH₂)₃—O—(CH₂)₄—, —(CH₂)₃—O—(CH₂)₅—, —(CH₂)₃—O—(CH₂)₆—, —(CH₂)₃—O—(CH₂)₇—, —(CH₂)₄—O—(CH₂)₁—, —(CH₂)₄—O—(CH₂)₂—, —(CH₂)₄—O—(CH₂)₃—, —(CH₂)₄—O—(CH₂)₄—, —(CH₂)₄—O—(CH₂)₅—, —(CH₂)₄—O—(CH₂)₆—, —(CH₂)₅—O—(CH₂)₁—, —(CH₂)₅—O—(CH₂)₂—, —(CH₂)₅—O—(CH₂)₃—, —(CH₂)₅—O—(CH₂)₄—, —(CH₂)₅—O—(CH₂)₅—, —(CH₂)₆—O—(CH₂)₁—, —(CH₂)₆—O—(CH₂)₂—, —(CH₂)₆—O—(CH₂)₃—, —(CH₂)₆—O—(CH₂)₄—, —(CH₂)₇—O—(CH₂)₁—, —(CH₂)₇—O—(CH₂)₂—, —(CH₂)₇—O—(CH₂)₃—, —(CH₂)₈—O—(CH₂)₁—, —(CH₂)₈—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₁—, —CH(CH₃)—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₃—, —CH(CH₃)—O—(CH₂)₄—, —CH(CH₃)—O—(CH₂)₅—, —CH(CH₃)—O—(CH₂)₆—, —CH(CH₃)—O—(CH₂)₇—, —CH(CH₃)—O—(CH₂)₈—, —CH(CH₃)—O—(CH₂)₉—, —CH(CH₃)—O—(CH₂)₁₀—, —CH₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₂)₆—, —CH₂—(O(CH₂)₂)₇—, —CH₂—(O(CH₂)₂)₈—, —CH₂—(O(CH₂)₂)₉—, —CH₂—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₂)₁—OCH₂—, —CH₂—(O(CH₂)₂)₂—OCH₂—, —CH₂—(O(CH₂)₂)₃—OCH₂—, —CH₂—(O(CH₂)₂)₄—OCH₂—, —CH₂—(O(CH₂)₂)₅—OCH₂—, —CH₂—(O(CH₂)₂)₆—OCH₂—, —CH₂—(O(CH₂)₂)₇—OCH₂—, —CH₂—(O(CH₂)₂)₈—OCH₂—, —CH₂—(O(CH₂)₂)₉—OCH₂—, —CH₂—(O(CH₂)₂)₁₀—OCH₂—, —(CH₂)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₂)₆—, —(CH₂)₂—(O(CH₂)₂)₇—, —(CH₂)₂—(O(CH₂)₂)₈—, —(CH₂)₂—(O(CH₂)₂)₉—, —(CH₂)₂—(O(CH₂)₂)₁₀—, —(CH₂)₃—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₂)₆—, —(CH₂)₃—(O(CH₂)₂)₇—, —(CH₂)₃—(O(CH₂)₂)₈—, —(CH₂)₃—(O(CH₂)₂)₉—, —(CH₂)₃—(O(CH₂)₂)₁₀—, —(CH₂)₄—(O(CH₂)₂)₂—, —(CH₂)₄—(O(CH₂)₂)₃—, —(CH₂)₄—(O(CH₂)₂)₄—, —(CH₂)₄—(O(CH₂)₂)₅—, —(CH₂)₄—(O(CH₂)₂)₆—, —(CH₂)₄—(O(CH₂)₂)₇—, —(CH₂)₄—(O(CH₂)₂)₈—, —(CH₂)₄—(O(CH₂)₂)₉—, —(CH₂)₄—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₃)₆—, —CH₂—(O(CH₂)₃)₇—, —CH₂—(O(CH₂)₃)₈—, —CH₂—(O(CH₂)₃)₉—, —CH₂—(O(CH₂)₃)₁₀—, —(CH₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₃)₆—, —(CH₂)₂—(O(CH₂)₃)₇—, —(CH₂)₂—(O(CH₂)₃)₈—, —(CH₂)₂—(O(CH₂)₃)₉—, —(CH₂)₂—(O(CH₂)₃)₁₀—, —(CH₂)₃—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₃)₆—, —(CH₂)₃—(O(CH₂)₃)₇—, —(CH₂)₃—(O(CH₂)₃)₈—, —(CH₂)₃—(O(CH₂)₃)₉—, —(CH₂)₃—(O(CH₂)₃)₁₀—, —CH₂—O—(CH₂)₂—O—(CH₂)₃—, —CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —CH₂—O—(CH₂)₃—O—(CH₂)₂—, —CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —CH₂—O—(CH₂)₂—O—CH₂—, —(CH₂)₂—O—(CH₂)₂O—CH₂—, —(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, —CH₂—C(O)—CH₂—, —CH₂—C(O)—(CH₂)₂—, —(CH₂)₁—C(O)—(CH₂)₃—, —(CH₂)₁—C(O)—(CH₂)₄—, —(CH₂)₁—C(O)—(CH₂)₅—, —(CH₂)₁—C(O)—(CH₂)₆—, —(CH₂)₁—C(O)—(CH₂)₇—, —(CH₂)₁—C(O)—(CH₂)₈—, —(CH₂)₁—C(O)—(CH₂)₉—, —(CH₂)₁—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁—, —(CH₂)₂—C(O)—(CH₂)₂—, —(CH₂)₂—C(O)—(CH₂)₃—, —(CH₂)₂—C(O)—(CH₂)₄—, —(CH₂)₂—C(O)—(CH₂)₅—, —(CH₂)₂—C(O)—(CH₂)₆—, —(CH₂)₂—C(O)—(CH₂)₇—, —(CH₂)₂—C(O)—(CH₂)₈—, —(CH₂)₂—C(O)—(CH₂)₉—, —(CH₂)₂—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁₁—, —(CH₂)₂—C(O)—(CH₂)₁₂—, —(CH₂)₃—C(O)—(CH₂)₁—, —(CH₂)₃—C(O)—(CH₂)₂—, —(CH₂)₃—C(O)—(CH₂)₃—, —(CH₂)₃—C(O)—(CH₂)₄—, —(CH₂)₃—C(O)—(CH₂)₅—, —(CH₂)₃—C(O)—(CH₂)₆—, —(CH₂)₃—C(O)—(CH₂)₇—, —(CH₂)₄—C(O)—(CH₂)₁—, —(CH₂)₄—C(O)—(CH₂)₂—, —(CH₂)₄—C(O)—(CH₂)₃—, —(CH₂)₄—C(O)—(CH₂)₄—, —(CH₂)₄—C(O)—(CH₂)₅—, —(CH₂)₄—C(O)—(CH₂)₆—, —(CH₂)₅—C(O)—(CH₂)₁—, —(CH₂)₅—C(O)—(CH₂)₂—, —(CH₂)₅—C(O)—(CH₂)₃—, —(CH₂)₅—C(O)—(CH₂)₄—, —(CH₂)₅—C(O)—(CH₂)₅—, —(CH₂)₆—C(O)—(CH₂)₁—, —(CH₂)₆—C(O)—(CH₂)₂—, —(CH₂)₆—C(O)—(CH₂)₃—, —(CH₂)₆—C(O)—(CH₂)₄—, —(CH₂)₇—C(O)—(CH₂)₁—, —(CH₂)₇—C(O)—(CH₂)₂—, —(CH₂)₇—C(O)—(CH₂)₃—, —(CH₂)₈—C(O)—(CH₂)₁—, —(CH₂)₈—C(O)—(CH₂)₂—, —CH₂—S—CH₂—, —CH₂—S—(CH₂)₂—, —(CH₂)₁—S—(CH₂)₃—, —(CH₂)₁—S—(CH₂)₄—, —(CH₂)₁—S—(CH₂)₅—, —(CH₂)₁—S—(CH₂)₆—, —(CH₂)₁—S—(CH₂)₇—, —(CH₂)₁—S—(CH₂)₈—, —(CH₂)₁—S—(CH₂)₉—, —(CH₂)₁—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁—, —(CH₂)₂—S—(CH₂)₂—, —(CH₂)₂—S—(CH₂)₃—, —(CH₂)₂—S—(CH₂)₄—, —(CH₂)₂—S—(CH₂)₅—, —(CH₂)₂—S—(CH₂)₆—, —(CH₂)₂—S—(CH₂)₇—, —(CH₂)₂—S—(CH₂)₈—, —(CH₂)₂—S—(CH₂)₉—, —(CH₂)₂—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁₁—, —(CH₂)₂—S—(CH₂)₁₂—, —(CH₂)₃—S—(CH₂)₁—, —(CH₂)₃—S—(CH₂)₂—, —(CH₂)₃—S—(CH₂)₃—, —(CH₂)₃—S—(CH₂)₄—, —(CH₂)₃—S—(CH₂)₅—, —(CH₂)₃—S—(CH₂)₆—, —(CH₂)₃—S—(CH₂)₇—, —(CH₂)₄—S—(CH₂)₁—, —(CH₂)₄—S—(CH₂)₂—, —(CH₂)₄—S—(CH₂)₃—, —(CH₂)₄—S—(CH₂)₄—, —(CH₂)₄—S—(CH₂)₅—, —(CH₂)₄—S—(CH₂)₆—, —(CH₂)₅—S—(CH₂)₁—, —(CH₂)₅—S—(CH₂)₂—, —(CH₂)₅—S—(CH₂)₃—, —(CH₂)₅—S—(CH₂)₄—, —(CH₂)₅—S—(CH₂)₅—, —(CH₂)₆—S—(CH₂)₁—, —(CH₂)₆—S—(CH₂)₂—, —(CH₂)₆—S—(CH₂)₃—, —(CH₂)₆—S—(CH₂)₄—, —(CH₂)₇—S—(CH₂)₁—, —(CH₂)₇—S—(CH₂)₂—, —(CH₂)₇—S—(CH₂)₃—, —(CH₂)₈—S—(CH₂)₁—, —(CH₂)₈—S—(CH₂)₂—, —CH₂—C(S)—CH₂—, —CH₂—C(S)—(CH₂)₂—, —(CH₂)₁—C(S)—(CH₂)₃—, —(CH₂)₁—C(S)—(CH₂)₄—, —(CH₂)₁—C(S)—(CH₂)₅—, —(CH₂)₁—C(S)—(CH₂)₆—, —(CH₂)₁—C(S)—(CH₂)₇—, —(CH₂)₁—C(S)—(CH₂)₈—, —(CH₂)₁—C(S)—(CH₂)₉—, —(CH₂)₁—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁—, —(CH₂)₂—C(S)—(CH₂)₂—, —(CH₂)₂—C(S)—(CH₂)₃—, —(CH₂)₂—C(S)—(CH₂)₄—, —(CH₂)₂—C(S)—(CH₂)₅—, —(CH₂)₂—C(S)—(CH₂)₆—, —(CH₂)₂—C(S)—(CH₂)₇—, —(CH₂)₂—C(S)—(CH₂)₈—, —(CH₂)₂—C(S)—(CH₂)₉—, —(CH₂)₂—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁₁—, —(CH₂)₂—C(S)—(CH₂)₁₂—, —(CH₂)₃—C(S)—(CH₂)₁—, —(CH₂)₃—C(S)—(CH₂)₂—, —(CH₂)₃—C(S)—(CH₂)₃—, —(CH₂)₃—C(S)—(CH₂)₄—, —(CH₂)₃—C(S)—(CH₂)₅—, —(CH₂)₃—C(S)—(CH₂)₆—, —(CH₂)₃—C(S)—(CH₂)₇—, —(CH₂)₄—C(S)—(CH₂)₁—, —(CH₂)₄—C(S)—(CH₂)₂—, —(CH₂)₄—C(S)—(CH₂)₃—, —(CH₂)₄—C(S)—(CH₂)₄—, —(CH₂)₄—C(S)—(CH₂)₅—, —(CH₂)₄—C(S)—(CH₂)₆—, —(CH₂)₅—C(S)—(CH₂)₁—, —(CH₂)₅—C(S)—(CH₂)₂—, —(CH₂)₅—C(S)—(CH₂)₃—, —(CH₂)₅—C(S)—(CH₂)₄—, —(CH₂)₅—C(S)—(CH₂)₅—, —(CH₂)₆—C(S)—(CH₂)₁—, —(CH₂)₆—C(S)—(CH₂)₂—, —(CH₂)₆—C(S)—(CH₂)₃—, —(CH₂)₆—C(S)—(CH₂)₄—, —(CH₂)₇—C(S)—(CH₂)₁—, —(CH₂)₇—C(S)—(CH₂)₂—, —(CH₂)₇—C(S)—(CH₂)₃—, —(CH₂)₈—C(S)—(CH₂)₁—, —(CH₂)₈—C(S)—(CH₂)₂—, —CH₂—C(O)O—CH₂—, —CH₂—C(O)O—(CH₂)₂—, —(CH₂)₁—C(O)O—(CH₂)₃—, —(CH₂)₁—C(O)O—(CH₂)₄—, —(CH₂)₁—C(O)O—(CH₂)₅—, —(CH₂)₁—C(O)O—(CH₂)₆—, —(CH₂)₁—C(O)O—(CH₂)₇—, —(CH₂)₁—C(O)O—(CH₂)₈—, —(CH₂)₁—C(O)O—(CH₂)₉—, —(CH₂)₁—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁—, —(CH₂)₂—C(O)O—(CH₂)₂—, —(CH₂)₂—C(O)O—(CH₂)₃—, —(CH₂)₂—C(O)O—(CH₂)₄—, —(CH₂)₂—C(O)O—(CH₂)₅—, —(CH₂)₂—C(O)O—(CH₂)₆—, —(CH₂)₂—C(O)O—(CH₂)₇—, —(CH₂)₂—C(O)O—(CH₂)₈—, —(CH₂)₂—C(O)O—(CH₂)₉—, —(CH₂)₂—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁₁—, —(CH₂)₂—C(O)O—(CH₂)₁₂—, —(CH₂)₃—C(O)O—(CH₂)₁—, —(CH₂)₃—C(O)O—(CH₂)₂—, —(CH₂)₃—C(O)O—(CH₂)₃—, —(CH₂)₃—C(O)O—(CH₂)₄—, —(CH₂)₃—C(O)O—(CH₂)₅—, —(CH₂)₃—C(O)O—(CH₂)₆—, —(CH₂)₃—C(O)O—(CH₂)₇—, —(CH₂)₄—C(O)O—(CH₂)₁—, —(CH₂)₄—C(O)O—(CH₂)₂—, —(CH₂)₄—C(O)O—(CH₂)₃—, —(CH₂)₄—C(O)O—(CH₂)₄—, —(CH₂)₄—C(O)O—(CH₂)₅—, —(CH₂)₄—C(O)O—(CH₂)₆—, —(CH₂)₅—C(O)O—(CH₂)₁—, —(CH₂)₅—C(O)O—(CH₂)₂—, —(CH₂)₅—C(O)O—(CH₂)₃—, —(CH₂)₅—C(O)O—(CH₂)₄—, —(CH₂)₅—C(O)O—(CH₂)₅—, —(CH₂)₆—C(O)O—(CH₂)₁—, —(CH₂)₆—C(O)O—(CH₂)₂—, —(CH₂)₆—C(O)O—(CH₂)₃—, —(CH₂)₆—C(O)O—(CH₂)₄—, —(CH₂)₇—C(O)O—(CH₂)₁—, —(CH₂)₇—C(O)O—(CH₂)₂—, —(CH₂)₇—C(O)O—(CH₂)₃—, —(CH₂)₈—C(O)O—(CH₂)₁—, —(CH₂)₈—C(O)O—(CH₂)₂—, —CH₂—OC(O)—CH₂—, —CH₂—OC(O)—(CH₂)₂—, —(CH₂)₁—OC(O)—(CH₂)₃—, —(CH₂)₁—OC(O)—(CH₂)₄—, —(CH₂)₁—OC(O)—(CH₂)₅—, —(CH₂)₁—OC(O)—(CH₂)₆—, —(CH₂)₁—OC(O)—(CH₂)₇—, —(CH₂)₁—OC(O)—(CH₂)₈—, —(CH₂)₁—OC(O)—(CH₂)₉—, —(CH₂)₁—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁—, —(CH₂)₂—OC(O)—(CH₂)₂—, —(CH₂)₂—OC(O)—(CH₂)₃—, —(CH₂)₂—OC(O)—(CH₂)₄—, —(CH₂)₂—OC(O)—(CH₂)₅—, —(CH₂)₂—OC(O)—(CH₂)₆—, —(CH₂)₂—OC(O)—(CH₂)₇—, —(CH₂)₂—OC(O)—(CH₂)₈—, —(CH₂)₂—OC(O)—(CH₂)₉—, —(CH₂)₂—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁₁—, —(CH₂)₂—OC(O)—(CH₂)₁₂—, —(CH₂)₃—OC(O)—(CH₂)₁—, —(CH₂)₃—OC(O)—(CH₂)₂—, —(CH₂)₃—OC(O)—(CH₂)₃—, —(CH₂)₃—OC(O)—(CH₂)₄—, —(CH₂)₃—OC(O)—(CH₂)₅—, —(CH₂)₃—OC(O)—(CH₂)₆—, —(CH₂)₃—OC(O)—(CH₂)₇—, —(CH₂)₄—OC(O)—(CH₂)₁—, —(CH₂)₄—OC(O)—(CH₂)₂—, —(CH₂)₄—OC(O)—(CH₂)₃—, —(CH₂)₄—OC(O)—(CH₂)₄—, —(CH₂)₄—OC(O)—(CH₂)₅—, —(CH₂)₄—OC(O)—(CH₂)₆—, —(CH₂)₅—OC(O)—(CH₂)₁—, —(CH₂)₅—OC(O)—(CH₂)₂—, —(CH₂)₅—OC(O)—(CH₂)₃—, —(CH₂)₅—OC(O)—(CH₂)₄—, —(CH₂)₅—OC(O)—(CH₂)₅—, —(CH₂)₆—OC(O)—(CH₂)₁—, —(CH₂)₆—OC(O)—(CH₂)₂—, —(CH₂)₆—OC(O)—(CH₂)₃—, —(CH₂)₆—OC(O)—(CH₂)₄—, —(CH₂)₇—OC(O)—(CH₂)₁—, —(CH₂)₇—OC(O)—(CH₂)₂—, —(CH₂)₇—OC(O)—(CH₂)₃—, —(CH₂)₈—OC(O)—(CH₂)₁—, —(CH₂)₈—OC(O)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₁—, —(CH₂)₁—N(R_g11)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₃—, —(CH₂)₁—N(R_g11)—(CH₂)₄—, —(CH₂)₁—N(R_g11)—(CH₂)₅—, —(CH₂)₁—N(R_g11)—(CH₂)₆—, —(CH₂)₁—N(R_g11)—(CH₂)₇—, —(CH₂)₁—N(R_g11)—(CH₂)₈—, —(CH₂)₁—N(R_g11)—(CH₂)₉—, —(CH₂)₁—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₂—, —(CH₂)₂—N(R_g11)—(CH₂)₃—, —(CH₂)₂—N(R_g11)—(CH₂)₄—, —(CH₂)₂—N(R_g11)—(CH₂)₅—, —(CH₂)₂—N(R_g11)—(CH₂)₆—, —(CH₂)₂—N(R_g11)—(CH₂)₇—, —(CH₂)₂—N(R_g11)—(CH₂)₈—, —(CH₂)₂—N(R_g11)—(CH₂)₉—, —(CH₂)₂—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)_n—, —(CH₂)₂—N(R_g11)—(CH₂)₁₂—, —(CH₂)₃—N(R_g11)—(CH₂)₁—, —(CH₂)₃—N(R_g11)—(CH₂)₂—, —(CH₂)₃—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₁—, —(CH₂)₄—N(R_g11)—(CH₂)₂—, —(CH₂)₄—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₁—, —(CH₂)₅—N(R_g11)—(CH₂)₂—, —(CH₂)₅—N(R_g11)—(CH₂)₃—, —(CH₂)₅—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₅—, —(CH₂)₆—N(R_g11)—(CH₂)₁—, —(CH₂)₆—N(R_g11)—(CH₂)₂—, —(CH₂)₆—N(R_g11)—(CH₂)₃—, —(CH₂)₇—N(R_g11)—(CH₂)₁—, —(CH₂)₇—N(R_g11)—(CH₂)₂—, —(CH₂)₇—N(R_g11)—(CH₂)₃—, —(CH₂)₈—N(R_g11)—(CH₂)₁—, —(CH₂)₈—N(R_g11)—(CH₂)₂—, —(CH₂)₈—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₁—, —CH(CH₃)—N(R_g11)—(CH₂)₂—, —CH(CH₃)—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₄—, —CH(CH₃)—N(R_g11)—(CH₂)₅—, —CH(CH₃)—N(R_g11)—(CH₂)₆—, —CH(CH₃)—N(R_g11)—(CH₂)₇—, —CH(CH₃)—N(R_g11)—(CH₂)₈—, —CH(CH₃)—N(R_g11)—(CH₂)₉—, —CH(CH₃)—N(R_g11)—(CH₂)₁₀—, —CH₂C(O)NHCH₂—, —(CH₂)₂C(O)NH(CH₂)₂—, —(CH₂)₂C(O)NH(CH₂)₃—, —(CH₂)₂C(O)NH(CH₂)₄—, —(CH₂)₂C(O)NH(CH₂)₅—, —(CH₂)₃C(O)NH(CH₂)₃—, —(CH₂)₃C(O)NH(CH₂)₄—, —(CH₂)₄C(O)NH(CH₂)₄—, —(CH₂)₅C(O)NH(CH₂)₅—, —(CH₂)₆C(O)NH(CH₂)₇—, —(CH₂)₆C(O)NH(CH₂)₆—, —(CH₂)₇C(O)NH(CH₂)₇—, —(CH₂)₈C(O)NH(CH₂)₈, —(CH₂)₉C(O)NH(CH₂)₉—, —(CH₂)₁₀C(O)NH(CH₂)₁₀—, —(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, —CH₂NHC(O)CH₂—, —(CH₂)₂NHC(O)(CH₂)₂—, —(CH₂)₂NHC(O)(CH₂)₃—, —(CH₂)₂NHC(O)(CH₂)₄—, —(CH₂)₂NHC(O)(CH₂)₅—, —(CH₂)₃NHC(O)(CH₂)₃—, —(CH₂)₃NHC(O)(CH₂)₄—, —(CH₂)₄NHC(O)(CH₂)₄—, —(CH₂)₅NHC(O)(CH₂)₅—, —(CH₂)₆NHC(O)(CH₂)₇—, —(CH₂)₆NHC(O)(CH₂)₆—, —(CH₂)₇NHC(O)(CH₂)₇—, —(CH₂)₈NHC(O)(CH₂)₈, —(CH₂)₉NHC(O)(CH₂)₉—, —(CH₂)₁₀NHC(O)(CH₂)₁₀—, —(CH₂)₄NHC(O)(CH₂)₈—, —(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, —(CH₂)₄NHC(O)CH₂—, —CH₂-piperidinylene-CH₂—, —CH₂-piperidinylene-(CH₂)₂—, —CH₂-piperidinylene-(CH₂)₃—, —CH₂-piperidinylene-(CH₂)₄—, —CH₂-piperidinylene-(CH₂)₅—, —CH₂-piperidinylene-(CH₂)₆—, —CH₂-piperidinylene-(CH₂)₇—, —CH₂-piperidinylene-(CH₂)₈—, —(CH₂)₂-piperidinylene-(CH₂)₁—, —(CH₂)₂-piperidinylene-(CH₂)₂—, —(CH₂)₂-piperidinylene-(CH₂)₃—, —(CH₂)₂-piperidinylene-(CH₂)₄—, —(CH₂)₂-piperidinylene-(CH₂)₅—, —(CH₂)₂-piperidinylene-(CH₂)₆—, —(CH₂)₂-piperidinylene-(CH₂)₇—, —(CH₂)₂-piperidinylene-(CH₂)₈—, —(CH₂)₃-piperidinylene-CH₂—, —(CH₂)₃-piperidinylene-(CH₂)₂—, —(CH₂)₃-piperidinylene-(CH₂)₃—, —(CH₂)₃-piperidinylene-(CH₂)₄—, —(CH₂)₃-piperidinylene-(CH₂)₅—, —(CH₂)₃-piperidinylene-(CH₂)₆—, —(CH₂)₃-piperidinylene-(CH₂)₇—, —(CH₂)₃-piperidinylene-(CH₂)₈—, —(CH₂)₄-piperidinylene-CH₂—, —(CH₂)₄-piperidinylene-(CH₂)₂—, —(CH₂)₄-piperidinylene-(CH₂)₃—, —(CH₂)₄-piperidinylene-(CH₂)₄—, —(CH₂)₄-piperidinylene-(CH₂)₅—, —(CH₂)₄-piperidinylene-(CH₂)₆—, —(CH₂)₄-piperidinylene-(CH₂)₇—, —(CH₂)₄-piperidinylene-(CH₂)₈—, —(CH₂)₅-piperidinylene-(CH₂)₁—, —(CH₂)₅-piperidinylene-(CH₂)₂—, —(CH₂)₅-piperidinylene-(CH₂)₃—, —(CH₂)₅-piperidinylene-(CH₂)₄—, —(CH₂)₅-piperidinylene-(CH₂)₅—, —(CH₂)₅-piperidinylene-(CH₂)₆—, —(CH₂)₅-piperidinylene-(CH₂)₇—, —(CH₂)₅-piperidinylene-(CH₂)₈—, —(CH₂)₆-piperidinylene-(CH₂)₁—, —(CH₂)₆-piperidinylene-(CH₂)₂—, —(CH₂)₆-piperidinylene-(CH₂)₃—, —(CH₂)₆-piperidinylene-(CH₂)₄—, —(CH₂)₆-piperidinylene-(CH₂)₅—, —(CH₂)₆-piperidinylene-(CH₂)₆—, —(CH₂)₆-piperidinylene-(CH₂)₇—, —(CH₂)₆-piperidinylene-(CH₂)₈—, —(CH₂)₇-piperidinylene-(CH₂)₁—, —(CH₂)₇-piperidinylene-(CH₂)₂—, —(CH₂)₇-piperidinylene-(CH₂)₃—, —(CH₂)₇-piperidinylene-(CH₂)₄—, —(CH₂)₇-piperidinylene-(CH₂)₅—, —(CH₂)₅-piperidinylene-CH₂—, —(CH₂)₅-piperidinylene-(CH₂)₂—, —(CH₂)₅-piperidinylene-(CH₂)₃—, —(CH₂)₅-piperidinylene-(CH₂)₄—, —(CH₂)₅-piperidinylene-(CH₂)₅—, —(CH₂)₅-piperidinylene-(CH₂)₆—, —(CH₂)₅-piperidinylene-(CH₂)₇—, —(CH₂)₅-piperidinylene-(CH₂)₈—, —CH₂-piperazinylene-CH₂—, —CH₂-piperazinylene-(CH₂)₂—, —CH₂-piperazinylene-(CH₂)₃—, —CH₂-piperazinylene-(CH₂)₄—, —CH₂-piperazinylene-(CH₂)₅—, —CH₂-piperazinylene-(CH₂)₆—, —CH₂-piperazinylene-(CH₂)₇—, —CH₂-piperazinylene-(CH₂)₈—, —(CH₂)₂-piperazinylene-(CH₂)₁—, —(CH₂)₂-piperazinylene-(CH₂)₂—, —(CH₂)₂-piperazinylene-(CH₂)₃—, —(CH₂)₂-piperazinylene-(CH₂)₄—, —(CH₂)₂-piperazinylene-(CH₂)₅—, —(CH₂)₂-piperazinylene-(CH₂)₆—, —(CH₂)₂-piperazinylene-(CH₂)₇—, —(CH₂)₂-piperazinylene-(CH₂)₈—, —(CH₂)₃-piperazinylene-CH₂—, —(CH₂)₃-piperazinylene-(CH₂)₂—, —(CH₂)₃-piperazinylene-(CH₂)₃—, —(CH₂)₃-piperazinylene-(CH₂)₄—, —(CH₂)₃-piperazinylene-(CH₂)₅—, —(CH₂)₃-piperazinylene-(CH₂)₆—, —(CH₂)₃-piperazinylene-(CH₂)₇—, —(CH₂)₃-piperazinylene-(CH₂)₈—, —(CH₂)₄-piperazinylene-CH₂—, —(CH₂)₄-piperazinylene-(CH₂)₂—, —(CH₂)₄-piperazinylene-(CH₂)₃—, —(CH₂)₄-piperazinylene-(CH₂)₄—, —(CH₂)₄-piperazinylene-(CH₂)₅—, —(CH₂)₄-piperazinylene-(CH₂)₆—, —(CH₂)₄-piperazinylene-(CH₂)₇—, —(CH₂)₄-piperazinylene-(CH₂)₈—, —(CH₂)₅-piperazinylene-(CH₂)₁—, —(CH₂)₅-piperazinylene-(CH₂)₂—, —(CH₂)₅-piperazinylene-(CH₂)₃—, —(CH₂)₅-piperazinylene-(CH₂)₄—, —(CH₂)₅-piperazinylene-(CH₂)₅—, —(CH₂)₅-piperazinylene-(CH₂)₆—, —(CH₂)₅-piperazinylene-(CH₂)₇—, —(CH₂)₅-piperazinylene-(CH₂)₈—, —(CH₂)₆-piperazinylene-(CH₂)₁—, —(CH₂)₆-piperazinylene-(CH₂)₂—, —(CH₂)₆-piperazinylene-(CH₂)₃—, —(CH₂)₆-piperazinylene-(CH₂)₄—, —(CH₂)₆-piperazinylene-(CH₂)₅—, —(CH₂)₆-piperazinylene-(CH₂)₆—, —(CH₂)₆-piperazinylene-(CH₂)₇—, —(CH₂)₆-piperazinylene-(CH₂)₈—, —(CH₂)₇-piperazinylene-(CH₂)₁—, —(CH₂)₇-piperazinylene-(CH₂)₂—, —(CH₂)₇-piperazinylene-(CH₂)₃—, —(CH₂)₇-piperazinylene-(CH₂)₄—, —(CH₂)₇-piperazinylene-(CH₂)₈—, —(CH₂)₈-piperazinylene-CH₂—, —(CH₂)₈-piperazinylene-(CH₂)₂—, —(CH₂)₈-piperazinylene-(CH₂)₃—, —(CH₂)₈-piperazinylene-(CH₂)₄—, —(CH₂)₈-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-(CH₂)₆—, —(CH₂)₈-piperazinylene-(CH₂)₇—, —(CH₂)₈-piperazinylene-(CH₂)₈—, —CH₂-propylene-CH₂—, —CH₂-propylene-(CH₂)₂—, —CH₂-propylene-(CH₂)₃—, —CH₂-propylene-(CH₂)₄—, —CH₂-propylene-(CH₂)₅—, —CH₂-propylene-(CH₂)₆—, —CH₂-propylene-(CH₂)₇—, —CH₂-propylene-(CH₂)₈—, —(CH₂)₂-propylene-(CH₂)₁—, —(CH₂)₂-propylene-(CH₂)₂—, —(CH₂)₂-propylene-(CH₂)₃—, —(CH₂)₂-propylene-(CH₂)₄—, —(CH₂)₂-propylene-(CH₂)₅—, —(CH₂)₂-propylene-(CH₂)₆—, —(CH₂)₂-propylene-(CH₂)₇—, —(CH₂)₂-propylene-(CH₂)₈—, —(CH₂)₃-propylene-CH₂—, —(CH₂)₃-propylene-(CH₂)₂—, —(CH₂)₃-propylene-(CH₂)₃—, —(CH₂)₃-propylene-(CH₂)₄—, —(CH₂)₃-propylene-(CH₂)₅—, —(CH₂)₃-propylene-(CH₂)₆—, —(CH₂)₃-propylene-(CH₂)₇—, —(CH₂)₃-propylene-(CH₂)₈—, —(CH₂)₄-propylene-CH₂—, —(CH₂)₄-propylene-(CH₂)₂—, —(CH₂)₄-propylene-(CH₂)₃—, —(CH₂)₄-propylene-(CH₂)₄—, —(CH₂)₄-propylene-(CH₂)₅—, —(CH₂)₄-propylene-(CH₂)₆—, —(CH₂)₄-propylene-(CH₂)₇—, —(CH₂)₄-propylene-(CH₂)₈—, —(CH₂)₅-propylene-(CH₂)₁—, —(CH₂)₅-propylene-(CH₂)₂—, —(CH₂)₅-propylene-(CH₂)₃—, —(CH₂)₅-propylene-(CH₂)₄—, —(CH₂)₅-propylene-(CH₂)₅—, —(CH₂)₅-propylene-(CH₂)₆—, —(CH₂)₅-propylene-(CH₂)₇—, —(CH₂)₅-propylene-(CH₂)₈—, —(CH₂)₆-propylene-(CH₂)₁—, —(CH₂)₆-propylene-(CH₂)₂—, —(CH₂)₆-propylene-(CH₂)₃—, —(CH₂)₆-propylene-(CH₂)₄—, —(CH₂)₆-propylene-(CH₂)₅—, —(CH₂)₆-propylene-(CH₂)₆—, —(CH₂)₆-propylene-(CH₂)₇—, —(CH₂)₆-propylene-(CH₂)₈—, —(CH₂)₇-propylene-(CH₂)₁—, —(CH₂)₇-propylene-(CH₂)₂—, —(CH₂)₇-propylene-(CH₂)₃—, —(CH₂)₇-propylene-(CH₂)₄—, —(CH₂)₇-propylene-(CH₂)₈—, —(CH₂)₈-propylene-CH₂—, —(CH₂)₈-propylene-(CH₂)₂—, —(CH₂)₈-propylene-(CH₂)₃—, —(CH₂)₈-propylene-(CH₂)₄—, —(CH₂)₈-propylene-(CH₂)₅—, —(CH₂)₈-propylene-(CH₂)₆—, —(CH₂)₈-propylene-(CH₂)₇—, —(CH₂)₈-propylene-(CH₂)₈—, —CH₂-diazacycloheptanylene-CH₂—, —CH₂-diazacycloheptanylene-(CH₂)₂—, —CH₂-diazacycloheptanylene-(CH₂)₃—, —CH₂-diazacycloheptanylene-(CH₂)₄—, —CH₂-diazacycloheptanylene-(CH₂)₅—, —CH₂-diazacycloheptanylene-(CH₂)₆—, —CH₂-diazacycloheptanylene-(CH₂)₇—, —CH₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₃-diazacycloheptanylene-CH₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₄-diazacycloheptanylene-CH₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-CH₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.2.1]octylene-CH₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.2]octylene-CH₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₈—;
  • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof; and
  • each R_g11 independently represents H or C_1-3 alkyl.

In some embodiments of the compound of Formula (I-1), L₂ represents the structure of the following formula:

In some embodiments of the compound of Formula (I-1), R_b1 represents:

• • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and the C_3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_1-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

In some embodiments of the compound of Formula (I-1), R_b1 represents:

In some embodiments, the compound of Formula (I) is also of Formula (I-2):

• • wherein R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_b, (R_1a)_n, R_a, R_1a and n are as defined in the compound of Formula (I) above and the embodiments thereof;
  • wherein R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents N(R_e1), O, S, alkynylene (e.g., C_2-6 alkynylene), alkenylene (e.g., C_2-6 alkenylene), optionally substituted cycloalkylene (e.g., optionally substituted C_3-20 cycloalkylene or optionally substituted C_3-15 cycloalkylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted arylene (e.g., optionally substituted C_6-10 arylene), or optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene or optionally substituted 5- to 15-membered heteroarylene), wherein R_e1 represents H or C_1-3 alkyl, or X₁ represents a bond;
  • L₁ represents:
    • optionally substituted linear or branched C_1-60 alkylene (e.g., C₁-C₄₀ alkylene, C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₈ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁ alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₅ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene), or
    • optionally substituted linear or branched C_2-60alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₅ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_e2 and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_e3 and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_e2 and R_e3 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R_e2, R_e3, or a combination of R_e2 and R_e3; wherein each R_e2 is independently selected from the group consisting of O, S, N(R_e4), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH, or NHS(O)₂, wherein R_e4 represents H or C_1-3 alkyl, and in case that two or more groups R_e2 are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R_e2 are not directly connected to each other; and wherein each R_e3 is independently selected from the group consisting of optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 5- to 15-membered heterocyclylene), optionally substituted arylene (e.g., optionally substituted C_6-10 arylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof;
  • X₂ represents C(O), S(O) or S(O)₂, or X₂ represents a bond;
  • R_a1 represents the following formula:

• • • wherein R_f1 represents:

—NCH₂CH₂N—;

wherein symbol * indicates the point of attachment to X₂, R_g1 represents H or C_1-3 alkyl, ring A represents cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15cycloalkylene) or heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), (R_g2)_n1 indicates that ring A is optionally substituted with n1 R_g2, wherein n1 represents an integer of 0 to 8, and each R_g2, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;

wherein symbol ** indicates the point of attachment to X₂, R_g3 represents H or C_1-3 alkyl, ring B represents cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15cycloalkylene) or heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), (R_g4)_n2 indicates that ring B is optionally substituted with n2 R_g4, wherein n2 represents an integer of 0 to 8, and each R_g4, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof; or

wherein ring C represents cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15-cycloalkylene) or heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), (R_g5)_n3 indicates that ring C is optionally substituted with n3 R_g5, wherein n3 represents an integer of 0 to 8, and each R_g5, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;

• • R_f2 represents H, halogen, C_1-3 alkyl or halogenated C_1-3 alkyl;
  • R_f3 represents H, halogen, C_1-3 alkyl, halogenated C_1-3 alkyl,

wherein ring D represents cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15-cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), arylene (e.g., C_6-10 arylene) or heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), (R_g6)_n4 indicates that ring D is optionally substituted with n4 R_g6, wherein n4 represents an integer of 0 to 8, and each R_g6, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6-cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;

• • R_f4 represents

wherein symbol *** indicates the point of attachment to R_fs, ring E represents cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15 cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), arylene (e.g., C_6-10 arylene) or heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), (R_g7)_n5 indicates that ring E is optionally substituted with n5 R_g7, wherein n5 represents an integer of 0 to 8, and each R_g7, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof; and

• • R_f5 represents H, halogen, C_1-3 alkyl, halogenated C_1-3 alkyl,

wherein ring F represents cycloalkyl (e.g., C_3-20cycloalkyl, or C_3-15cycloalkyl), heterocyclyl (e.g., 4- to 20-membered heterocyclyl, or 5- to 15-membered heterocyclyl), aryl (e.g., C_6-10 aryl) or heteroaryl (e.g., 5- to 20-membered heteroaryl, or 5- to 15-membered heteroaryl), (R_g8)_n6 indicates that ring F is optionally substituted with n6 R_g8, wherein n6 represents an integer of 0 to 8, and each R_g5, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;

• • and
  • R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkyl, C₁-C₂₉ alkyl, C₁-C₂₈ alkyl, C₁-C₂₇ alkyl, C₁-C₂₆ alkyl, C₁-C₂₅ alkyl, C₁-C₂₄ alkyl, C₁-C₂₃ alkyl, C₁-C₂₂ alkyl, C₁-C₂₁ alkyl, C₁-C₂₀ alkyl, C₁-C₁₉ alkyl, C₁-C₁₅ alkyl, C₁-C₁₇ alkyl, C₁-C₁₆ alkyl, C₁-C₁₅ alkyl, C₁-C₁₄ alkyl, C₁-C₁₃ alkyl, C₁-C₁₂ alkyl, C₁-C₁₁ alkyl, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₅ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, or C₁-C₂ alkyl) optionally substituted with D or halogen, or
  • R_b represents the following formula:

R_b1—X₄-L₂-,

• • • wherein L₂ represents:
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₅ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene), or
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₅ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 4- to 15-membered heterocyclylene), arylene (e.g., C_6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene, arylene and the heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
    • X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(═S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted arylene (e.g., optionally substituted C_6-20 arylene, or optionally substituted C_6-10 arylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, or X₄ represents a bond; and
    • R_b1 represents optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl, or optionally substituted C_6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 4- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl).

In some embodiments of the compound of Formula (I-2), R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents N(R_e1), O, S, C_2-6 alkynylene, C_2-6 alkenylene, optionally substituted C_3-20cycloalkylene (e.g., optionally substituted C_3-15cycloalkylene), optionally substituted 4- to 20-membered heterocyclylene (e.g., optionally substituted 4- to 15-membered heterocyclylene), optionally substituted C_6-15 arylene (e.g., optionally substituted C_6-10 arylene), or optionally substituted 5- to 20-membered heteroarylene (e.g., optionally substituted 5- to 15-membered heteroarylene), wherein R_e1 represents H or C_1-3 alkyl, or X₁ represents a bond;
  • L₁ represents:
    • optionally substituted linear or branched C_1-60 alkylene (e.g., C₁-C₄₀ alkylene, C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₈ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁ alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₅ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene), or
    • optionally substituted linear or branched C_2-60alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₅ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_e2 and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_e3 and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_e2 and R_e3 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R_e2, R_e3, or a combination of R_e2 and R_e3; wherein each R_e2 is independently selected from the group consisting of O, S, N(R_e4), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH, or NHS(O)₂, wherein R_e4 represents H or C_1-3 alkyl, and in case that two or more groups R_e2 are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R_e2 are not directly connected to each other; and wherein each R_e3 is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the linear or branched C_1-60 alkylene and the linear or branched C_2-60 alkylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C_1-6 alkyl (e.g., halogenated C_1-4 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), or any combination thereof;
  • X₂ represents C(O) or S(O)₂, or X₂ represents a bond;
  • R_a1 represents the following formula:

• • • wherein R_f1 represents:

—NCH₂CH₂N—;

• • •  wherein symbol * indicates the point of attachment to X₂, R_g1 represents H or C_1-3 alkyl, ring A represents C_3-20cycloalkylene or 4- to 20-membered heterocyclylene, (R_g2)_n1 indicates that ring A is optionally substituted with n1 R_g2, wherein n1 represents an integer of 0 to 8, and each R_g2, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C_1-6 alkyl (e.g., halogenated C_1-4 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-6 alkylene (e.g., NH₂—C_1-4 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—) or any combination thereof;

• • •  wherein symbol ** indicates the point of attachment to X₂, R_g3 represents H or C_1-3 alkyl, ring B represents C_3-20cycloalkylene or 4- to 20-membered heterocyclylene, (R_g4)_n2 indicates that ring B is optionally substituted with n2 R_g4, wherein n2 represents an integer of 0 to 8, and each R_g4, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C_1-6 alkyl (e.g., halogenated C_1-4 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-6 alkylene (e.g., NH₂—C_1-4 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—) or any combination thereof; or

• • •  wherein ring C represents C_3-20cycloalkylene or 4- to 20-membered heterocyclylene, (R_g5)_n3 indicates that ring C is optionally substituted with n3 R_g5, wherein n3 represents an integer of 0 to 8, and each R_g5, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C_1-6 alkyl (e.g., halogenated C_1-4 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-6 alkylene (e.g., NH₂—C_1-4 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—) or any combination thereof;
      • R_f2 represents H, halogen, C_1-3 alkyl or halogenated C_1-3 alkyl (e.g., F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—);
      • R_f3 represents H, halogen, C_1-3 alkyl, halogenated C_1-3 alkyl (e.g., F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or —CH₂ClCH₂—),

wherein ring D represents C_3-20cycloalkylene, 4- to 20-membered heterocyclylene, C_6-15 arylene or 5- to 20-membered heteroarylene, (R_g6)_n4 indicates that ring D is optionally substituted with n4R_g6, wherein n4 represents an integer of 0 to 8, and each R_g6, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C_1-6 alkyl (e.g., halogenated C_1-4 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-6 alkylene (e.g., NH₂—C_1-4 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—) or any combination thereof;

• • • • R_f4 represents

wherein symbol *** indicates the point of attachment to R_f5, ring E represents C_3-20cycloalkylene, 4- to 20-membered heterocyclylene, C_6-15 arylene or 5- to 20-membered heteroarylene, (R_g7)_n5 indicates that ring E is optionally substituted with n5 R_g7, wherein n5 represents an integer of 0 to 8, and each R_g7, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C_1-6 alkyl (e.g., halogenated C_1-4 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-6 alkylene (e.g., NH₂—C_1-4 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—) or any combination thereof; and

• • • • R_f5 represents H, halogen, C_1-3 alkyl, halogenated C_1-3 alkyl,

wherein ring F represents C_3-20cycloalkyl, 4- to 20-membered heterocyclyl, C_6-15 aryl or 5- to 20-membered heteroaryl, (R_g8)_n6 indicates that ring F is optionally substituted with n6 R_g5, wherein n6 represents an integer of 0 to 8, and each R_g8, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), halogenated C_1-6 alkyl (e.g., halogenated C_1-4 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-6 alkylene (e.g., NH₂—C_1-4 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—) or any combination thereof;

In some embodiments of the compound of Formula (I-2), X₁ represents a bond.

In some embodiments of the compound of Formula (I-2), X₁ represents: N(R_e1), O, S, C_2-6 alkynylene, C_2-6 alkenylene, optionally substituted C_3-20cycloalkylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted C_6-15 arylene, or optionally substituted 5- to 20-membered heteroarylene, wherein R_e1 represents H or C_1-3 alkyl, wherein the C_3-20cycloalkylene, the 4- to 20-membered heterocyclylene, the C_6-15 arylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-2), X₁ represents N(R_e1), O, S, C_2-6 alkynylene or C_2-6 alkenylene, wherein R_e1 represents H or C_1-3 alkyl.

In some embodiments of the compound of Formula (I-2), X₁ represents:

• • cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene or bicyclo[2.2.1]heptenylene, with each group being optionally substituted with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogenated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenylene or naphthylene, wherein the phenylene or naphthylene is optionally substituted with one or more (e.g., 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogenated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogenated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene or imidazo[2,1-b]thiazolylene, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, halogenated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof. In embodiments of the present disclosure, the number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

In some embodiments of the compound of Formula (1-2), X₁ represents NH, N(CH₃), O, S, ethynylene or vinylene.

In some embodiments of the compound of Formula (1-2), X₁ represents:

wherein symbol # indicates the point of attachment to L₁.

In some embodiments of the compound of Formula (I-2), R_a1 represents the following formula:

• • wherein R_f1 represents:

—NCH₂CH₂N—;

wherein symbol * indicates the point of attachment to X₂, R_g1 represents H or C_1-3 alkyl, and ring A represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, and (R_g2)_n1 indicates that ring A is optionally substituted with n1 R_g2, wherein n1 represents an integer of 0 to 8, and each R_g2, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;

wherein symbol ** indicates the point of attachment to X₂, R_g3 represents H or C_1-3 alkyl, and ring B represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, and

• • • (R_g4)_n2 indicates that ring B is optionally substituted with n2 R_g4, wherein n2 represents an integer of 0 to 8, and each R_g4, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof; or

wherein ring C represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, and

• • • (R_g5)_n3 indicates that ring C is optionally substituted with n3 R_g5, n3 represents an integer of 0 to 8, and each R_g5, the same or different from each other, is independently selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;
  • R_f2 represents H, halogen, C_1-3 alkyl or halogenated C_1-3 alkyl;
  • R_f3 represents H, halogen, C_1-3 alkyl, halogenated C_1-3 alkyl,

wherein ring D represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene, 7-azaspiro[3.5]nonylene, phenylene, naphthylene, furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene or imidazo[2,1-b]thiazolylene, and

• • • (R_g6)_n4 indicates that ring D is optionally substituted with n4 R_g6, wherein n4 represents an integer of 0 to 8, and each R_g6, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof;
  • R_f4 represents

wherein symbol *** indicates the point of attachment to R_f5, and ring E represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene, bicyclo[2.2.1]heptenylene, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene, 7-azaspiro[3.5]nonylene, phenylene, naphthylene, furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene or imidazo[2,1-b]thiazolylene, and

• • • (R_g7)_n5 indicates that ring E is optionally substituted with n5 R_g7, wherein n5 represents an integer of 0 to 8, and each R_g7, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof; and
  • R_f5 represents H, halogen, C_1-3 alkyl, halogenated C_1-3 alkyl,

wherein ring F represents: cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl, bicyclo[2.2.1]heptenyl, azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl, 7-azaspiro[3.5]nonyl, phenyl, naphthyl, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, and

• • • (R_g8)_n6 indicates that ring F is optionally substituted with n6 R_g5, wherein n6 represents an integer of 0 to 8, and each R_g5, the same or different from each other, is independently selected from the group consisting of optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene or any combination thereof.

In some embodiments of the compound of Formula (I-2), R_a1 represents the following formula:

In some embodiments of the compound of Formula (I-2), L₁ represents the structure of the following formula:

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—(R_d1(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—(R_d1(C(R^d5)(R^a6))_m3)_p2—(R_d1(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—(R_d2(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—(R_d2(C(R^a5)(R^a6))_m3)_p2—(R_d2(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(R_d1—R_d2—(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R_d1(C(R^a3)(R^a4))_m2)_p1—(R_d2(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R_d2—R_d1—(C(R^a3)(R^a4))_m2)_p1—; or

##—(C(R^a1)(R^a2))_m1—(R_d2(C(R^a3)(R^a4))_m2)_p1—(R_d1(C(R^a5)(R^a6))_m3)_p2—;

• • wherein each group R_e2 is independently selected from the group consisting of O, S, N(R_e4), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R_e4 independently represents H or C_1-3 alkyl; and each group R_e3 is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), optionally deuterated C_1-6 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-6 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-6 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), optionally deuterated C_1-6 alkyl-NHC(O)— (e.g., C_1-4 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), optionally deuterated C_1-6 alkyl-C(O)NH— (e.g., C_1-4 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof;
  • R^a1, R^a2, R^a3, R^a4, R^a5, R^a6, R^a7 and R^a8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogenated C_1-6 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), optionally deuterated C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), optionally deuterated C_1-6 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), NH₂—C_1-6 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), optionally deuterated C_1-6 alkyl-NHC(O)— (e.g., C_1-4 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), optionally deuterated C_1-6 alkyl-C(O)NH— (e.g., C_1-4 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof;
  • symbol ## indicates the point of attachment to X₁; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-2), L₁ represents the structure of the following formula:

##—(C(R^a1)(R^a2))_m1—(O(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(O(C(R^a3)(R^a4))_m2)_p1—(O(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(O(C(R^a3)(R^a4))_m2)_p1—(O(C(R^a5)(R^a6))_m3)_p2—(O(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(N(R_g9)(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(N(R_g9)(C(R^a3)(R^a4))_m2)_p1—(N(R_g9)(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(N(R_g9)(C(R^a3)(R^a4))_m2)_p1—(N(R_g9)(C(R^a5)(R^a6))_m3)_p2—(N(R_g9)(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(C(O)NH—(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(C(O)NH—(C(R^a3)(R^a4))_m2)_p1—(C(O)NH—(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(C(O)NH—(C(R^a3)(R^a4))_m2)_p1—(C(O)NH—(C(R^a5)(R^a6))_m3)_p2—(C(O)NH—(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(C(O)NH—(C(R^a3)(R^a4))_m2)_p1—(O—(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1(—C(O)NH—(C(R^a3)(R^a4))_m2—(O(C(R^a5)(R^a6))_m3)_p1—;

##—(C(R^a1)(R^a2))_m1—(NHC(O)—(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(NHC(O)—(C(R^a3)(R^a4))_m2)_p1—(—O—(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(NHC(O)—(C(R^a3)(R^a4))_m2)_p1—(O—(C(R^a5)(R^a6))_m3)_p2—(O—(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—NHC(O)—(C(R^a3)(R^a4))_m2—(O(C(R^a5)(R^a6))_m3)_p1—;

##—(C(R^a1)(R^a2))_m1—NHC(O)NH—(C(R^a3)(R^a4))_m2—;

##—(C(R^a1)(R^a2))_m1—C(O)—(C(R^a3)(R^a4))_m2—;

##—(C(R^a1)(R^a2))_m1—C(S)—(C(R^a3)(R^a4))_m2—;

##—(C(R^a1)(R^a2))_m1—S—(C(R^a3)(R^a4))_m2—;

##—(C(R^a1)(R^a2))_m1—(C_6-10 arylene-(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(C_6-10 arylene-(C(R^a3)(R^a4))_m2)_p1—C_6-10 arylene-(C(R^a5)(R^a6))_m3—;

##—(C(R^a1)(R^a2))_m1-(4- to 15-membered heterocyclylene-(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1-(4- to 15-membered heterocyclylene-(C(R^a3)(R^a4))_m2)_p1-(4- to 15-membered heterocyclylene-(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1-(5- to 15-membered heteroarylene-(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1-(5- to 15-membered heteroarylene-(C(R^a3)(R^a4))_m2)_p1—(5- to 15-membered heteroarylene-(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(C_3-15cycloalkylene-(C(R^a3)(R^a4))_m2)_p1—; or

##—(C(R^a1)(R^a2))_m1—(C_3-15cycloalkylene-(C(R^a3)(R^a4))_m2)_p1—(C_3-15cycloalkylene-(C(R^a5)(R^a6))_m3)_p2—;

• • wherein each R_g9 independently represents H or C_1-3 alkyl;
  • the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, halogenated C_1-6 alkyl, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH—, cyano or any combination thereof;
  • R^a1, R^a2, R^a3, R^a4, R^a5, R^a6, R^a7 and R^a8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH— or any combination thereof;
  • symbol ## indicates the point of attachment to X₁; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-2), L₁ represents the following group:

• • ##—CH₂—O—CH₂—, ##—CH₂—O—(CH₂)₂—, ##—(CH₂)₁—O—(CH₂)₃—, ##—(CH₂)₁—O—(CH₂)₄—, ##—(CH₂)₁—O—(CH₂)₅—, ##—(CH₂)₁—O—(CH₂)₆—, ##—(CH₂)₁—O—(CH₂)₇—, ##—(CH₂)₁—O—(CH₂)₈—, ##—(CH₂)₁—O—(CH₂)₉—, ##—(CH₂)₁—O—(CH₂)₁₀—, ##—(CH₂)₂—O—(CH₂)₁—, ##—(CH₂)₂—O—(CH₂)₂—, ##—(CH₂)₂—O—(CH₂)₃—, ##—(CH₂)₂—O—(CH₂)₄—, ##—(CH₂)₂—O—(CH₂)₅—, ##—(CH₂)₂—O—(CH₂)₆—, ##—(CH₂)₂—O—(CH₂)₇—, ##—(CH₂)₂—O—(CH₂)₈—, ##—(CH₂)₂—O—(CH₂)₉—, ##—(CH₂)₂—O—(CH₂)₁₀—, ##—(CH₂)₂—O—(CH₂)₁₁—, ##—(CH₂)₂—O—(CH₂)₁₂—, ##—(CH₂)₃—O—(CH₂)₁—, ##—(CH₂)₃—O—(CH₂)₂—, ##—(CH₂)₃—O—(CH₂)₃—, ##—(CH₂)₃—O—(CH₂)₄—, ##—(CH₂)₃—O—(CH₂)₅—, ##—(CH₂)₃—O—(CH₂)₆—, ##—(CH₂)₃—O—(CH₂)₇—, ##—(CH₂)₄—O—(CH₂)₁—, ##—(CH₂)₄—O—(CH₂)₂—, ##—(CH₂)₄—O—(CH₂)₃—, ##—(CH₂)₄—O—(CH₂)₄—, ##—(CH₂)₄—O—(CH₂)₅—, ##—(CH₂)₄—O—(CH₂)₆—, ##—(CH₂)₅—O—(CH₂)₁—, ##—(CH₂)₅—O—(CH₂)₂—, ##—(CH₂)₅—O—(CH₂)₃—, ##—(CH₂)₅—O—(CH₂)₄—, ##—(CH₂)₅—O—(CH₂)₅—, ##—(CH₂)₆—O—(CH₂)₁—, ##—(CH₂)₆—O—(CH₂)₂—, ##—(CH₂)₆—O—(CH₂)₃—, ##—(CH₂)₆—O—(CH₂)₄—, ##—(CH₂)₇—O—(CH₂)₁—, ##—(CH₂)₇—O—(CH₂)₂—, ##—(CH₂)₇—O—(CH₂)₃—, ##—(CH₂)₈—O—(CH₂)₁—, ##—(CH₂)₈—O—(CH₂)₂—, ##—CH(CH₃)—O—(CH₂)₁—, ##—CH(CH₃)—O—(CH₂)₂—, ##—CH(CH₃)—O—(CH₂)₃—, ##—CH(CH₃)—O—(CH₂)₄—, ##—CH(CH₃)—O—(CH₂)₅—, ##—CH(CH₃)—O—(CH₂)₆—, ##—CH(CH₃)—O—(CH₂)₇—, ##—CH(CH₃)—O—(CH₂)₈—, ##—CH(CH₃)—O—(CH₂)₉—, ##—CH(CH₃)—O—(CH₂)₁₀—, ##—CH₂—(O(CH₂)₂)₂—, ##—CH₂—(O(CH₂)₂)₃—, ##—CH₂—(O(CH₂)₂)₄—, ##—CH₂—(O(CH₂)₂)₅—, ##—CH₂—(O(CH₂)₂)₆—, ##—CH₂—(O(CH₂)₂)₇—, ##—CH₂—(O(CH₂)₂)₈—, ##—CH₂—(O(CH₂)₂)₉—, ##—CH₂—(O(CH₂)₂)₁₀—, ##—CH₂—(O(CH₂)₂)₁—OCH₂—, ##—CH₂—(O(CH₂)₂)₂—OCH₂—, ##—CH₂—(O(CH₂)₂)₃—OCH₂—, ##—CH₂—(O(CH₂)₂)₄—OCH₂—, ##—CH₂—(O(CH₂)₂)₅—OCH₂—, ##—CH₂—(O(CH₂)₂)₆—OCH₂—, ##—CH₂—(O(CH₂)₂)₇—OCH₂—, ##—CH₂—(O(CH₂)₂)₈—OCH₂—, ##—CH₂—(O(CH₂)₂)₉—OCH₂—, ##—CH₂—(O(CH₂)₂)₁₀—OCH₂—, ##—(CH₂)₂—(O(CH₂)₂)₂—, ##—(CH₂)₂—(O(CH₂)₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₄—, ##—(CH₂)₂—(O(CH₂)₂)₅—, ##—(CH₂)₂—(O(CH₂)₂)₆—, ##—(CH₂)₂—(O(CH₂)₂)₇—, ##—(CH₂)₂—(O(CH₂)₂)₈—, ##—(CH₂)₂—(O(CH₂)₂)₉—, ##—(CH₂)₂—(O(CH₂)₂)₁₀—, ##—(CH₂)₃—(O(CH₂)₂)₂—, ##—(CH₂)₃—(O(CH₂)₂)₃—, ##—(CH₂)₃—(O(CH₂)₂)₄—, ##—(CH₂)₃—(O(CH₂)₂)₅—, ##—(CH₂)₃—(O(CH₂)₂)₆—, ##—(CH₂)₃—(O(CH₂)₂)₇—, ##—(CH₂)₃—(O(CH₂)₂)₈—, ##—(CH₂)₃—(O(CH₂)₂)₉—, ##—(CH₂)₃—(O(CH₂)₂)₁₀—, ##—(CH₂)₄—(O(CH₂)₂)₂—, ##—(CH₂)₄—(O(CH₂)₂)₃—, ##—(CH₂)₄—(O(CH₂)₂)₄—, ##—(CH₂)₄—(O(CH₂)₂)₅—, ##—(CH₂)₄—(O(CH₂)₂)₆—, ##—(CH₂)₄—(O(CH₂)₂)₇—, ##—(CH₂)₄—(O(CH₂)₂)₈—, ##—(CH₂)₄—(O(CH₂)₂)₉—, ##—(CH₂)₄—(O(CH₂)₂)₁₀—, ##—CH₂—(O(CH₂)₃)₂—, ##—CH₂—(O(CH₂)₃)₃—, ##—CH₂—(O(CH₂)₃)₄—, ##—CH₂—(O(CH₂)₃)₅—, ##—CH₂—(O(CH₂)₃)₆—, ##—CH₂—(O(CH₂)₃)₇—, ##—CH₂—(O(CH₂)₃)₈—, ##—CH₂—(O(CH₂)₃)₉—, ##—CH₂—(O(CH₂)₃)₁₀—, ##—(CH₂)₂—(O(CH₂)₃)₂—, ##—(CH₂)₂—(O(CH₂)₃)₃—, ##—(CH₂)₂—(O(CH₂)₃)₄—, ##—(CH₂)₂—(O(CH₂)₃)₅—, ##—(CH₂)₂—(O(CH₂)₃)₆—, ##—(CH₂)₂—(O(CH₂)₃)₇—, ##—(CH₂)₂—(O(CH₂)₃)₈—, ##—(CH₂)₂—(O(CH₂)₃)₉—, ##—(CH₂)₂—(O(CH₂)₃)₁₀—, ##—(CH₂)₃—(O(CH₂)₃)₂—, ##—(CH₂)₃—(O(CH₂)₃)₃—, ##—(CH₂)₃—(O(CH₂)₃)₄—, ##—(CH₂)₃—(O(CH₂)₃)₅—, ##—(CH₂)₃—(O(CH₂)₃)₆—, ##—(CH₂)₃—(O(CH₂)₃)₇—, ##—(CH₂)₃—(O(CH₂)₃)₈—, ##—(CH₂)₃—(O(CH₂)₃)₉—, ##—(CH₂)₃—(O(CH₂)₃)₁₀—, ##—CH₂—O—(CH₂)₂—O—(CH₂)₃—, ##—CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, ##—CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, ##—CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, ##—CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, ##—CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, ##—(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, ##—(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, ##—(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, ##—(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, ##—(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, ##—(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, ##—(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, ##—(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, ##—(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, ##—(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, ##—(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, ##—CH₂—O—(CH₂)₃—O—(CH₂)₂—, ##—CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, ##—CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, ##—CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, ##—CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, ##—CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, ##—(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, ##—(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, ##—(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, ##—(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, ##—(CH₂)₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, ##—(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, ##—(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, ##—(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, ##—(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, ##—(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, ##—(CH₂)₃—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, ##—(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, ##—CH₂—O—(CH₂)₂O—CH₂—, ##—(CH₂)₂—O—(CH₂)₂O—CH₂—, ##—(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, ##—(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, ##—(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, ##—CH₂—C(O)—CH₂—, ##—CH₂—C(O)—(CH₂)₂—, ##—(CH₂)₁—C(O)—(CH₂)₃—, ##—(CH₂)₁—C(O)—(CH₂)₄—, ##—(CH₂)₁—C(O)—(CH₂)₅—, ##—(CH₂)₁—C(O)—(CH₂)₆—, ##—(CH₂)₁—C(O)—(CH₂)₇—, ##—(CH₂)₁—C(O)—(CH₂)₈—, ##—(CH₂)₁—C(O)—(CH₂)₉—, ##—(CH₂)₁—C(O)—(CH₂)₁₀—, ##—(CH₂)₂—C(O)—(CH₂)₁—, ##—(CH₂)₂—C(O)—(CH₂)₂—, ##—(CH₂)₂—C(O)—(CH₂)₃—, ##—(CH₂)₂—C(O)—(CH₂)₄—, ##—(CH₂)₂—C(O)—(CH₂)₅—, ##—(CH₂)₂—C(O)—(CH₂)₆—, ##—(CH₂)₂—C(O)—(CH₂)₇—, ##—(CH₂)₂—C(O)—(CH₂)₈—, ##—(CH₂)₂—C(O)—(CH₂)₉—, ##—(CH₂)₂—C(O)—(CH₂)₁₀—, ##—(CH₂)₂—C(O)—(CH₂)₁₁—, ##—(CH₂)₂—C(O)—(CH₂)₁₂—, ##—(CH₂)₃—C(O)—(CH₂)₁—, ##—(CH₂)₃—C(O)—(CH₂)₂—, ##—(CH₂)₃—C(O)—(CH₂)₃—, ##—(CH₂)₃—C(O)—(CH₂)₄—, ##—(CH₂)₃—C(O)—(CH₂)₅—, ##—(CH₂)₃—C(O)—(CH₂)₆—, ##—(CH₂)₃—C(O)—(CH₂)₇—, ##—(CH₂)₄—C(O)—(CH₂)₁—, ##—(CH₂)₄—C(O)—(CH₂)₂—, ##—(CH₂)₄—C(O)—(CH₂)₃—, ##—(CH₂)₄—C(O)—(CH₂)₄—, ##—(CH₂)₄—C(O)—(CH₂)₅—, ##—(CH₂)₄—C(O)—(CH₂)₆—, ##—(CH₂)₅—C(O)—(CH₂)₁—, ##—(CH₂)₅—C(O)—(CH₂)₂—, ##—(CH₂)₅—C(O)—(CH₂)₃—, ##—(CH₂)₅—C(O)—(CH₂)₄—, ##—(CH₂)₅—C(O)—(CH₂)₅—, ##—(CH₂)₆—C(O)—(CH₂)₁—, ##—(CH₂)₆—C(O)—(CH₂)₂—, ##—(CH₂)₆—C(O)—(CH₂)₃—, ##—(CH₂)₆—C(O)—(CH₂)₄—, ##—(CH₂)₇—C(O)—(CH₂)₁—, ##—(CH₂)₇—C(O)—(CH₂)₂—, ##—(CH₂)₇—C(O)—(CH₂)₃—, ##—(CH₂)₈—C(O)—(CH₂)₁—, ##—(CH₂)₈—C(O)—(CH₂)₂—, ##—CH₂—S—CH₂—, ##—CH₂—S—(CH₂)₂—, ##—(CH₂)₁—S—(CH₂)₃—, ##—(CH₂)₁—S—(CH₂)₄—, ##—(CH₂)₁—S—(CH₂)₅—, ##—(CH₂)₁—S—(CH₂)₆—, ##—(CH₂)₁—S—(CH₂)₇—, ##—(CH₂)₁—S—(CH₂)₈—, ##—(CH₂)₁—S—(CH₂)₉—, ##—(CH₂)₁—S—(CH₂)₁₀—, ##—(CH₂)₂—S—(CH₂)₁—, ##—(CH₂)₂—S—(CH₂)₂—, ##—(CH₂)₂—S—(CH₂)₃—, ##—(CH₂)₂—S—(CH₂)₄—, ##—(CH₂)₂—S—(CH₂)₅—, ##—(CH₂)₂—S—(CH₂)₆—, ##—(CH₂)₂—S—(CH₂)₇—, ##—(CH₂)₂—S—(CH₂)₈—, ##—(CH₂)₂—S—(CH₂)₉—, ##—(CH₂)₂—S—(CH₂)₁₀—, ##—(CH₂)₂—S—(CH₂)₁₁—, ##—(CH₂)₂—S—(CH₂)₁₂—, ##—(CH₂)₃—S—(CH₂)₁—, ##—(CH₂)₃—S—(CH₂)₂—, ##—(CH₂)₃—S—(CH₂)₃—, ##—(CH₂)₃—S—(CH₂)₄—, ##—(CH₂)₃—S—(CH₂)₅—, ##—(CH₂)₃—S—(CH₂)₆—, ##—(CH₂)₃—S—(CH₂)₇—, ##—(CH₂)₄—S—(CH₂)₁—, ##—(CH₂)₄—S—(CH₂)₂—, ##—(CH₂)₄—S—(CH₂)₃—, ##—(CH₂)₄—S—(CH₂)₄—, ##—(CH₂)₄—S—(CH₂)₅—, ##—(CH₂)₄—S—(CH₂)₆—, ##—(CH₂)₅—S—(CH₂)₁—, ##—(CH₂)₅—S—(CH₂)₂—, ##—(CH₂)₅—S—(CH₂)₃—, ##—(CH₂)₅—S—(CH₂)₄—, ##—(CH₂)₅—S—(CH₂)₅—, ##—(CH₂)₆—S—(CH₂)₁—, ##—(CH₂)₆—S—(CH₂)₂—, ##—(CH₂)₆—S—(CH₂)₃—, ##—(CH₂)₆—S—(CH₂)₄—, ##—(CH₂)₇—S—(CH₂)₁—, ##—(CH₂)₇—S—(CH₂)₂—, ##—(CH₂)₇—S—(CH₂)₃—, ##—(CH₂)₈—S—(CH₂)₁—, ##—(CH₂)₈—S—(CH₂)₂—, ##—CH₂—C(S)—CH₂—, ##—CH₂—C(S)—(CH₂)₂—, ##—(CH₂)₁—C(S)—(CH₂)₃—, ##—(CH₂)₁—C(S)—(CH₂)₄—, ##—(CH₂)₁—C(S)—(CH₂)₅—, ##—(CH₂)₁—C(S)—(CH₂)₆—, ##—(CH₂)₁—C(S)—(CH₂)₇—, ##—(CH₂)₁—C(S)—(CH₂)₈—, ##—(CH₂)₁—C(S)—(CH₂)₉—, ##—(CH₂)₁—C(S)—(CH₂)₁₀—, ##—(CH₂)₂—C(S)—(CH₂)₁—, ##—(CH₂)₂—C(S)—(CH₂)₂—, ##—(CH₂)₂—C(S)—(CH₂)₃—, ##—(CH₂)₂—C(S)—(CH₂)₄—, ##—(CH₂)₂—C(S)—(CH₂)₅—, ##—(CH₂)₂—C(S)—(CH₂)₆—, ##—(CH₂)₂—C(S)—(CH₂)₇—, ##—(CH₂)₂—C(S)—(CH₂)₈—, ##—(CH₂)₂—C(S)—(CH₂)₉—, ##—(CH₂)₂—C(S)—(CH₂)₁₀—, ##—(CH₂)₂—C(S)—(CH₂)₁₁—, ##—(CH₂)₂—C(S)—(CH₂)₁₂—, ##—(CH₂)₃—C(S)—(CH₂)₁—, ##—(CH₂)₃—C(S)—(CH₂)₂—, ##—(CH₂)₃—C(S)—(CH₂)₃—, ##—(CH₂)₃—C(S)—(CH₂)₄—, ##—(CH₂)₃—C(S)—(CH₂)₅—, ##—(CH₂)₃—C(S)—(CH₂)₆—, ##—(CH₂)₃—C(S)—(CH₂)₇—, ##—(CH₂)₄—C(S)—(CH₂)₁—, ##—(CH₂)₄—C(S)—(CH₂)₂—, ##—(CH₂)₄—C(S)—(CH₂)₃—, ##—(CH₂)₄—C(S)—(CH₂)₄—, ##—(CH₂)₄—C(S)—(CH₂)₅—, ##—(CH₂)₄—C(S)—(CH₂)₆—, ##—(CH₂)₅—C(S)—(CH₂)₁—, ##—(CH₂)₅—C(S)—(CH₂)₂—, ##—(CH₂)₅—C(S)—(CH₂)₃—, ##—(CH₂)₅—C(S)—(CH₂)₄—, ##—(CH₂)₅—C(S)—(CH₂)₅—, ##—(CH₂)₆—C(S)—(CH₂)₁—, ##—(CH₂)₆—C(S)—(CH₂)₂—, ##—(CH₂)₆—C(S)—(CH₂)₃—, ##—(CH₂)₆—C(S)—(CH₂)₄—, ##—(CH₂)₇—C(S)—(CH₂)₁—, ##—(CH₂)₇—C(S)—(CH₂)₂—, ##—(CH₂)₇—C(S)—(CH₂)₃—, ##—(CH₂)₈—C(S)—(CH₂)₁—, ##—(CH₂)₈—C(S)—(CH₂)₂—, ##—CH₂—C(O)O—CH₂—, ##—CH₂—C(O)O—(CH₂)₂—, ##—(CH₂)₁—C(O)O—(CH₂)₃—, ##—(CH₂)₁—C(O)O—(CH₂)₄—, ##—(CH₂)₁—C(O)O—(CH₂)₅—, ##—(CH₂)₁—C(O)O—(CH₂)₆—, ##—(CH₂)₁—C(O)O—(CH₂)₇—, ##—(CH₂)₁—C(O)O—(CH₂)₈—, ##—(CH₂)₁—C(O)O—(CH₂)₉—, ##—(CH₂)₁—C(O)O—(CH₂)₁₀—, ##—(CH₂)₂—C(O)O—(CH₂)₁—, ##—(CH₂)₂—C(O)O—(CH₂)₂—, ##—(CH₂)₂—C(O)O—(CH₂)₃—, ##—(CH₂)₂—C(O)O—(CH₂)₄—, ##—(CH₂)₂—C(O)O—(CH₂)₅—, ##—(CH₂)₂—C(O)O—(CH₂)₆—, ##—(CH₂)₂—C(O)O—(CH₂)₇—, ##—(CH₂)₂—C(O)O—(CH₂)₈—, ##—(CH₂)₂—C(O)O—(CH₂)₉—, ##—(CH₂)₂—C(O)O—(CH₂)₁₀—, ##—(CH₂)₂—C(O)O—(CH₂)₁₁—, ##—(CH₂)₂—C(O)O—(CH₂)₁₂—, ##—(CH₂)₃—C(O)O—(CH₂)₁—, ##—(CH₂)₃—C(O)O—(CH₂)₂—, ##—(CH₂)₃—C(O)O—(CH₂)₃—, ##—(CH₂)₃—C(O)O—(CH₂)₄—, ##—(CH₂)₃—C(O)O—(CH₂)₅—, ##—(CH₂)₃—C(O)O—(CH₂)₆—, ##—(CH₂)₃—C(O)O—(CH₂)₇—, ##—(CH₂)₄—C(O)O—(CH₂)₁—, ##—(CH₂)₄—C(O)O—(CH₂)₂—, ##—(CH₂)₄—C(O)O—(CH₂)₃—, ##—(CH₂)₄—C(O)O—(CH₂)₄—, ##—(CH₂)₄—C(O)O—(CH₂)₅—, ##—(CH₂)₄—C(O)O—(CH₂)₆—, ##—(CH₂)₅—C(O)O—(CH₂)₁—, ##—(CH₂)₅—C(O)O—(CH₂)₂—, ##—(CH₂)₅—C(O)O—(CH₂)₃—, ##—(CH₂)₅—C(O)O—(CH₂)₄—, ##—(CH₂)₅—C(O)O—(CH₂)₅—, ##—(CH₂)₆—C(O)O—(CH₂)₁—, ##—(CH₂)₆—C(O)O—(CH₂)₂—, ##—(CH₂)₆—C(O)O—(CH₂)₃—, ##—(CH₂)₆—C(O)O—(CH₂)₄—, ##—(CH₂)₇—C(O)O—(CH₂)₁—, ##—(CH₂)₇—C(O)O—(CH₂)₂—, ##—(CH₂)₇—C(O)O—(CH₂)₃—, ##—(CH₂)₈—C(O)O—(CH₂)₁—, ##—(CH₂)₈—C(O)O—(CH₂)₂—, ##—CH₂—OC(O)—CH₂—, ##—CH₂—OC(O)—(CH₂)₂—, ##—(CH₂)₁—OC(O)—(CH₂)₃—, ##—(CH₂)₁—OC(O)—(CH₂)₄—, ##—(CH₂)₁—OC(O)—(CH₂)₅—, ##—(CH₂)₁—OC(O)—(CH₂)₆—, ##—(CH₂)₁—OC(O)—(CH₂)₇—, ##—(CH₂)₁—OC(O)—(CH₂)₈—, ##—(CH₂)₁—OC(O)—(CH₂)₉—, ##—(CH₂)₁—OC(O)—(CH₂)₁₀—, ##—(CH₂)₂—OC(O)—(CH₂)₁—, ##—(CH₂)₂—OC(O)—(CH₂)₂—, ##—(CH₂)₂—OC(O)—(CH₂)₃—, ##—(CH₂)₂—OC(O)—(CH₂)₄—, ##—(CH₂)₂—OC(O)—(CH₂)₅—, ##—(CH₂)₂—OC(O)—(CH₂)₆—, ##—(CH₂)₂—OC(O)—(CH₂)₇—, ##—(CH₂)₂—OC(O)—(CH₂)₈—, ##—(CH₂)₂—OC(O)—(CH₂)₉—, ##—(CH₂)₂—OC(O)—(CH₂)₁₀—, ##—(CH₂)₂—OC(O)—(CH₂)₁₁—, ##—(CH₂)₂—OC(O)—(CH₂)₁₂—, ##—(CH₂)₃—OC(O)—(CH₂)₁—, ##—(CH₂)₃—OC(O)—(CH₂)₂—, ##—(CH₂)₃—OC(O)—(CH₂)₃—, ##—(CH₂)₃—OC(O)—(CH₂)₄—, ##—(CH₂)₃—OC(O)—(CH₂)₅—, ##—(CH₂)₃—OC(O)—(CH₂)₆—, ##—(CH₂)₃—OC(O)—(CH₂)₇—, ##—(CH₂)₄—OC(O)—(CH₂)₁—, ##—(CH₂)₄—OC(O)—(CH₂)₂—, ##—(CH₂)₄—OC(O)—(CH₂)₃—, ##—(CH₂)₄—OC(O)—(CH₂)₄—, ##—(CH₂)₄—OC(O)—(CH₂)₅—, ##—(CH₂)₄—OC(O)—(CH₂)₆—, ##—(CH₂)₅—OC(O)—(CH₂)₁—, ##—(CH₂)₅—OC(O)—(CH₂)₂—, ##—(CH₂)₅—OC(O)—(CH₂)₃—, ##—(CH₂)₅—OC(O)—(CH₂)₄—, ##—(CH₂)₅—OC(O)—(CH₂)₅—, ##—(CH₂)₆—OC(O)—(CH₂)₁—, ##—(CH₂)₆—OC(O)—(CH₂)₂—, ##—(CH₂)₆—OC(O)—(CH₂)₃—, ##—(CH₂)₆—OC(O)—(CH₂)₄—, ##—(CH₂)₇—OC(O)—(CH₂)₁—, ##—(CH₂)₇—OC(O)—(CH₂)₂—, ##—(CH₂)₇—OC(O)—(CH₂)₃—, ##—(CH₂)₈—OC(O)—(CH₂)₁—, ##—(CH₂)₈—OC(O)—(CH₂)₂—, ##—(CH₂)₁—N(R_g10)—(CH₂)₁—, ##—(CH₂)₁—N(R_g10)—(CH₂)₂—, ##—(CH₂)₁—N(R_g10)—(CH₂)₃—, ##—(CH₂)₁—N(R_g10)—(CH₂)₄—, ##—(CH₂)₁—N(R_g10)—(CH₂)₅—, ##—(CH₂)₁—N(R_g10)—(CH₂)₆—, ##—(CH₂)₁—N(R_g10)—(CH₂)₇—, ##—(CH₂)₁—N(R_g10)—(CH₂)₈—, ##—(CH₂)₁—N(R_g10)—(CH₂)₉—, ##—(CH₂)₁—N(R_g10)—(CH₂)₁₀—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁—, ##—(CH₂)₂—N(R_g10)—(CH₂)₂—, ##—(CH₂)₂—N(R_g10)—(CH₂)₃—, ##—(CH₂)₂—N(R_g10)—(CH₂)₄—, ##—(CH₂)₂—N(R_g10)—(CH₂)₅—, ##—(CH₂)₂—N(R_g10)—(CH₂)₆—, ##—(CH₂)₂—N(R_g10)—(CH₂)₇—, ##—(CH₂)₂—N(R_g10)—(CH₂)₈—, ##—(CH₂)₂—N(R_g10)—(CH₂)₉—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁₀—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁₁—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁₂—, ##—(CH₂)₃—N(R_g10)—(CH₂)₁—, ##—(CH₂)₃—N(R_g10)—(CH₂)₂—, ##—(CH₂)₃—N(R_g10)—(CH₂)₃—, ##—(CH₂)₄—N(R_g10)—(CH₂)₁—, ##—(CH₂)₄—N(R_g10)—(CH₂)₂—, ##—(CH₂)₄—N(R_g10)—(CH₂)₃—, ##—(CH₂)₄—N(R_g10)—(CH₂)₄—, ##—(CH₂)₅—N(R_g10)—(CH₂)₁—, ##—(CH₂)₅—N(R_g10)—(CH₂)₂—, ##—(CH₂)₅—N(R_g10)—(CH₂)₃—, ##—(CH₂)₅—N(R_g10)—(CH₂)₄—, ##—(CH₂)₅—N(R_g10)—(CH₂)₅—, ##—(CH₂)₆—N(R_g10)—(CH₂)₁—, ##—(CH₂)₆—N(R_g10)—(CH₂)₂—, ##—(CH₂)₆—N(R_g10)—(CH₂)₃—, ##—(CH₂)₇—N(R_g10)—(CH₂)₁—, ##—(CH₂)₇—N(R_g10)—(CH₂)₂—, ##—(CH₂)₇—N(R_g10)—(CH₂)₃—, ##—(CH₂)₈—N(R_g10)—(CH₂)₁—, ##—(CH₂)₈—NR_g10)—(CH₂)₂—, ##—(CH₂)₈—N(R_g10)—(CH₂)₃—, ##—CH(CH₃)—N(R_g10)—(CH₂)₁—, ##—CH(CH₃)—N(R_g10)—(CH₂)₂—, ##—CH(CH₃)—N(R_g10)—(CH₂)₃—, ##—CH(CH₃)—N(R_g10)—(CH₂)₄—, ##—CH(CH₃)—N(R_g10)—(CH₂)₅—, ##—CH(CH₃)—N(R_g10)—(CH₂)₆—, ##—CH(CH₃)—N(R_g10)—(CH₂)₇—, ##—CH(CH₃)—N(R_g10)—(CH₂)₈—, ##—CH(CH₃)—N(R_g10)—(CH₂)₉—, ##—CH(CH₃)—N(R_g10)—(CH₂)₁₀—, ##—CH₂C(O)NHCH₂—, ##—(CH₂)₂C(O)NH(CH₂)₂—, ##—(CH₂)₂C(O)NH(CH₂)₃—, ##—(CH₂)₂C(O)NH(CH₂)₄—, ##—(CH₂)₂C(O)NH(CH₂)₅—, ##—(CH₂)₃C(O)NH(CH₂)₃—, ##—(CH₂)₃C(O)NH(CH₂)₄—, ##—(CH₂)₄C(O)NH(CH₂)₄—, ##—(CH₂)₅C(O)NH(CH₂)₅—, ##—(CH₂)₅C(O)NH(CH₂)₇—, ##—(CH₂)₆C(O)NH(CH₂)₆—, ##—(CH₂)₇C(O)NH(CH₂)₇—, ##—(CH₂)₅C(O)NH(CH₂)₈, ##—(CH₂)₉C(O)NH(CH₂)₉—, ##—(CH₂)₁₀C(O)NH(CH₂)₁₀—, ##—(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, ##—CH₂NHC(O)CH₂—, ##—(CH₂)₂NHC(O)(CH₂)₂—, ##—(CH₂)₂NHC(O)(CH₂)₃—, ##—(CH₂)₂NHC(O)(CH₂)₄—, ##—(CH₂)₂NHC(O)(CH₂)₅—, ##—(CH₂)₃NHC(O)(CH₂)₃—, ##—(CH₂)₃NHC(O)(CH₂)₄—, ##—(CH₂)₄NHC(O)(CH₂)₄—, ##—(CH₂)₅NHC(O)(CH₂)₅—, ##—(CH₂)₆NHC(O)(CH₂)₇—, ##—(CH₂)₆NHC(O)(CH₂)₆—, ##—(CH₂)₇NHC(O)(CH₂)₇—, ##—(CH₂)₅NHC(O)(CH₂)₈, ##—(CH₂)₉NHC(O)(CH₂)₉—, ##—(CH₂)₁₀NHC(O)(CH₂)₁₀—, ##—(CH₂)₄NHC(O)(CH₂)₈—, ##—(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, ##—(CH₂)₄NHC(O)CH₂—, ##—CH₂-piperidinylene-CH₂—, ##—CH₂-piperidinylene-(CH₂)₂—, ##—CH₂-piperidinylene-(CH₂)₃—, ##—CH₂-piperidinylene-(CH₂)₄—, ##—CH₂-piperidinylene-(CH₂)₅—, ##—CH₂-piperidinylene-(CH₂)₆—, ##—CH₂-piperidinylene-(CH₂)₂—, ##—CH₂-piperidinylene-(CH₂)₈—, ##—(CH₂)₂-piperidinylene-(CH₂)₁—, ##—(CH₂)₂-piperidinylene-(CH₂)—, ##—(CH₂)₂-piperidinylene-(CH₂)₃—, ##—(CH₂)₂-piperidinylene-(CH₂)₄—, ##—(CH₂)₂-piperidinylene-(CH₂)₅—, ##—(CH₂)₂-piperidinylene-(CH₂)₆—, ##—(CH₂)₂-piperidinylene-(CH₂)₇—, ##—(CH₂)₂-piperidinylene-(CH₂)₈—, ##—(CH₂)₃-piperidinylene-CH₂—, ##—(CH₂)₃-piperidinylene-(CH₂)₂—, ##—(CH₂)₃-piperidinylene-(CH₂)₃—, ##—(CH₂)₃-piperidinylene-(CH₂)₄—, ##—(CH₂)₃-piperidinylene-(CH₂)₅—, ##—(CH₂)₃-piperidinylene-(CH₂)₆—, ##—(CH₂)₃-piperidinylene-(CH₂)₇—, ##—(CH₂)₃-piperidinylene-(CH₂)₈—, ##—(CH₂)₄-piperidinylene-CH₂—, ##—(CH₂)₄-piperidinylene-(CH₂)₂—, ##—(CH₂)₄-piperidinylene-(CH₂)₃—, ##—(CH₂)₄-piperidinylene-(CH₂)₄—, ##—(CH₂)₄-piperidinylene-(CH₂)₅—, ##—(CH₂)₄-piperidinylene-(CH₂)₆—, ##—(CH₂)₄-piperidinylene-(CH₂)₇—, ##—(CH₂)₄-piperidinylene-(CH₂)₈—, ##—(CH₂)₅-piperidinylene-(CH₂)₁—, ##—(CH₂)₅-piperidinylene-(CH₂)₂—, ##—(CH₂)₅-piperidinylene-(CH₂)₃—, ##—(CH₂)₅-piperidinylene-(CH₂)₄—, ##—(CH₂)₅-piperidinylene-(CH₂)₅—, ##—(CH₂)₅-piperidinylene-(CH₂)₆—, ##—(CH₂)₅-piperidinylene-(CH₂)₇—, ##—(CH₂)₅-piperidinylene-(CH₂)₈—, ##—(CH₂)₆-piperidinylene-(CH₂)₁—, ##—(CH₂)₆-piperidinylene-(CH₂)₂—, ##—(CH₂)₆-piperidinylene-(CH₂)₃—, ##—(CH₂)₆-piperidinylene-(CH₂)₄—, ##—(CH₂)₆-piperidinylene-(CH₂)₅—, ##—(CH₂)₆-piperidinylene-(CH₂)₆—, ##—(CH₂)₆-piperidinylene-(CH₂)₇—, ##—(CH₂)₆-piperidinylene-(CH₂)₈—, ##—(CH₂)₇-piperidinylene-(CH₂)₁—, ##—(CH₂)₇-piperidinylene-(CH₂)₂—, ##—(CH₂)₇-piperidinylene-(CH₂)₃—, ##—(CH₂)₇-piperidinylene-(CH₂)₄—, ##—(CH₂)₇-piperidinylene-(CH₂)₈—, ##—(CH₂)₈-piperidinylene-CH₂—, ##—(CH₂)₈-piperidinylene-(CH₂)₂—, ##—(CH₂)₈-piperidinylene-(CH₂)₃—, ##—(CH₂)₈-piperidinylene-(CH₂)₄—, ##—(CH₂)₈-piperidinylene-(CH₂)₅—, ##—(CH₂)₈-piperidinylene-(CH₂)₆—, ##—(CH₂)₈-piperidinylene-(CH₂)₇—, ##—(CH₂)₈-piperidinylene-(CH₂)₈—, ##—CH₂-piperazinylene-CH₂—, ##—CH₂-piperazinylene-(CH₂)₂—, ##—CH₂-piperazinylene-(CH₂)₃—, ##—CH₂-piperazinylene-(CH₂)₄—, ##—CH₂-piperazinylene-(CH₂)₅—, ##—CH₂-piperazinylene-(CH₂)₆—, ##—CH₂-piperazinylene-(CH₂)₇—, ##—CH₂-piperazinylene-(CH₂)₈—, ##—(CH₂)₂-piperazinylene-(CH₂)₁—, ##—(CH₂)₂-piperazinylene-(CH₂)₂—, ##—(CH₂)₂-piperazinylene-(CH₂)₃—, ##—(CH₂)₂-piperazinylene-(CH₂)₄—, ##—(CH₂)₂-piperazinylene-(CH₂)₅—, ##—(CH₂)₂-piperazinylene-(CH₂)₆—, ##—(CH₂)₂-piperazinylene-(CH₂)₇—, ##—(CH₂)₂-piperazinylene-(CH₂)₈—, ##—(CH₂)₃-piperazinylene-CH₂—, ##—(CH₂)₃-piperazinylene-(CH₂)₂—, ##—(CH₂)₃-piperazinylene-(CH₂)₃—, ##—(CH₂)₃-piperazinylene-(CH₂)₄—, ##—(CH₂)₃-piperazinylene-(CH₂)₅—, ##—(CH₂)₃-piperazinylene-(CH₂)₆—, ##—(CH₂)₃-piperazinylene-(CH₂)₇—, ##—(CH₂)₃-piperazinylene-(CH₂)₈—, ##—(CH₂)₄-piperazinylene-CH₂—, ##—(CH₂)₄-piperazinylene-(CH₂)₂—, ##—(CH₂)₄-piperazinylene-(CH₂)₃—, ##—(CH₂)₄-piperazinylene-(CH₂)₄—, ##—(CH₂)₄-piperazinylene-(CH₂)₅—, ##—(CH₂)₄-piperazinylene-(CH₂)₆—, ##—(CH₂)₄-piperazinylene-(CH₂)₇—, ##—(CH₂)₄-piperazinylene-(CH₂)₈—, ##—(CH₂)₅-piperazinylene-(CH₂)₁—, ##—(CH₂)₅-piperazinylene-(CH₂)₂—, ##—(CH₂)₅-piperazinylene-(CH₂)₃—, ##—(CH₂)₅-piperazinylene-(CH₂)₄—, ##—(CH₂)₅-piperazinylene-(CH₂)₅—, ##—(CH₂)₅-piperazinylene-(CH₂)₆—, ##—(CH₂)₅-piperazinylene-(CH₂)₇—, ##—(CH₂)₅-piperazinylene-(CH₂)₈—, ##—(CH₂)₆-piperazinylene-(CH₂)₁—, ##—(CH₂)₆-piperazinylene-(CH₂)₂—, ##—(CH₂)₆-piperazinylene-(CH₂)₃—, ##—(CH₂)₆-piperazinylene-(CH₂)₄—, ##—(CH₂)₆-piperazinylene-(CH₂)₅—, ##—(CH₂)₆-piperazinylene-(CH₂)₆—, ##—(CH₂)₆-piperazinylene-(CH₂)₇—, ##—(CH₂)₆-piperazinylene-(CH₂)₈—, ##—(CH₂)₇-piperazinylene-(CH₂)₁—, ##—(CH₂)₇-piperazinylene-(CH₂)₂—, ##—(CH₂)₇-piperazinylene-(CH₂)₃—, ##—(CH₂)₇-piperazinylene-(CH₂)₄—, ##—(CH₂)₇-piperazinylene-(CH₂)₈—, ##—(CH₂)₈-piperazinylene-CH₂—, ##—(CH₂)₈-piperazinylene-(CH₂)₂—, ##—(CH₂)₈-piperazinylene-(CH₂)₃—, ##—(CH₂)₈-piperazinylene-(CH₂)₄—, ##—(CH₂)₈-piperazinylene-(CH₂)₅—, ##—(CH₂)₈-piperazinylene-(CH₂)₆—, ##—(CH₂)₈-piperazinylene-(CH₂)₇—, ##—(CH₂)₈-piperazinylene-(CH₂)₈—, ##—CH₂-propylene-CH₂—, ##—CH₂-propylene-(CH₂)₂—, ##—CH₂-propylene-(CH₂)₃—, ##—CH₂-propylene-(CH₂)₄—, ##—CH₂-propylene-(CH₂)₅—, ##—CH₂-propylene-(CH₂)₆—, ##—CH₂-propylene-(CH₂)₇—, ##—CH₂-propylene-(CH₂)₈—, ##—(CH₂)₂-propylene-(CH₂)₁—, ##—(CH₂)₂-propylene-(CH₂)₂—, ##—(CH₂)₂-propylene- (CH₂)₃—, ##—(CH₂)₂-propylene-(CH₂)₄—, ##—(CH₂)₂-propylene-(CH₂)₅—, ##—(CH₂)₂-propylene-(CH₂)₆—, ##—(CH₂)₂-propylene-(CH₂)₇—, ##—(CH₂)₂-propylene-(CH₂)₈—, ##—(CH₂)₃-propylene-CH₂—, ##—(CH₂)₃-propylene-(CH₂)₂—, ##—(CH₂)₃-propylene-(CH₂)₃—, ##—(CH₂)₃-propylene-(CH₂)₄—, ##—(CH₂)₃-propylene- (CH₂)₅—, ##—(CH₂)₃-propylene-(CH₂)₆—, ##—(CH₂)₃-propylene-(CH₂)₇—, ##—(CH₂)₃-propylene-(CH₂)₈—, ##—(CH₂)₄-propylene-CH₂—, ##—(CH₂)₄-propylene-(CH₂)₂—, ##—(CH₂)₄-propylene-(CH₂)₃—, ##—(CH₂)₄-propylene-(CH₂)₄—, ##—(CH₂)₄-propylene-(CH₂)₅—, ##—(CH₂)₄-propylene-(CH₂)₆—, ##—(CH₂)₄-propylene- (CH₂)₇—, ##—(CH₂)₄-propylene-(CH₂)₅—, ##—(CH₂)₅-propylene-(CH₂)₁—, ##—(CH₂)₅-propylene-(CH₂)₂—, ##—(CH₂)₅-propylene-(CH₂)₃—, ##—(CH₂)₅-propylene-(CH₂)₄—, ##—(CH₂)₅-propylene-(CH₂)₅—, ##—(CH₂)₅-propylene-(CH₂)₆—, ##—(CH₂)₅-propylene-(CH₂)₇—, ##—(CH₂)₅-propylene-(CH₂)₈—, ##—(CH₂)₆-propylene- (CH₂)₁—, ##—(CH₂)₆-propylene-(CH₂)₂—, ##—(CH₂)₆-propylene-(CH₂)₃—, ##—(CH₂)₆-propylene-(CH₂)₄—, ##—(CH₂)₆-propylene-(CH₂)₅—, ##—(CH₂)₆-propylene-(CH₂)₆—, ##—(CH₂)₆-propylene-(CH₂)₇—, ##—(CH₂)₆-propylene-(CH₂)₈—, ##—(CH₂)₇-propylene-(CH₂)₁—, ##—(CH₂)₇-propylene-(CH₂)₂—, ##—(CH₂)₇-propylene- (CH₂)₃—, ##—(CH₂)₇-propylene-(CH₂)₄—, ##—(CH₂)₇-propylene-(CH₂)₈—, ##—(CH₂)₈-propylene-CH₂—, ##—(CH₂)₈-propylene-(CH₂)₂—, ##—(CH₂)₈-propylene-(CH₂)₃—, ##—(CH₂)₈-propylene-(CH₂)₄—, ##—(CH₂)₈-propylene-(CH₂)₈—, ##—(CH₂)₈-propylene-(CH₂)₆—, ##—(CH₂)₈-propylene-(CH₂)₇—, ##—(CH₂)₈-propylene- (CH₂)₈—, ##—CH₂-diazacycloheptanylene-CH₂—, ##—CH₂-diazacycloheptanylene-(CH₂)₂—, ##—CH₂-diazacycloheptanylene-(CH₂)₃—, ##—CH₂-diazacycloheptanylene-(CH₂)₄—, ##—CH₂-diazacycloheptanylene-(CH₂)₈—, ##—CH₂-diazacycloheptanylene-(CH₂)₆—, ##—CH₂-diazacycloheptanylene-(CH₂)₇—, ##—CH₂-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₃-diazacycloheptanylene-CH₂—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₄-diazacycloheptanylene-CH₂—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₈-diazacycloheptanylene-CH₂—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—CH₂-diazabicyclo[3.2.1]octylene-CH₂—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—CH₂-diazabicyclo[2.2.2]octylene-CH₂—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-CH₂—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—;
  • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • each R_g10 independently represents H or C_1-3 alkyl; and
  • symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-2), L₁ represents the following group:

• • wherein symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-2), L₁ represents the structure of the following formula: ##—C_1-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_1-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-2), L₁ represents the following group: ##—CH₂—, ##—(CH₂)₂—, ##—(CH₂)₃—, ##—(CH₂)₄—, ##—(CH₂)₅—, ##—(CH₂)₂—CF₂—(CH₂)₂—, ##—(CH₂)₆—, ##—(CH₂)₇—, ##—(CH₂)₈—, ##—(CH₂)₉—, ##—(CH₂)₁₀—, ##—(CH₂)₁₁—, ##—(CH₂)₁₂—, ##—(CH₂)₁₃—, ##—(CH₂)₁₄—, ##—(CH₂)₁₅—, ##—(CH₂)₁₆—, ##—(CH₂)₁₇—, ##—(CH₂)₁₈—, ##—(CH₂)₁₉—, ##—(CH₂)₂₀—, ##—(CH₂)₂₁—, ##—(CH₂)₂₂—, ##—(CH₂)₂₅—, or ##—(CH₂)₃₀—;

• • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-2), R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkyl, C₁-C₂₉ alkyl, C₁-C₂₈ alkyl, C₁-C₂₇ alkyl, C₁-C₂₆ alkyl, C₁-C₂₅ alkyl, C₁-C₂₄ alkyl, C₁-C₂₃ alkyl, C₁-C₂₂ alkyl, C₁-C₂₁ alkyl, C₁-C₂₀ alkyl, C₁-C₁₉ alkyl, C₁-C₁₈ alkyl, C₁-C₁₇ alkyl, C₁-C₁₆ alkyl, C₁-C₁₅ alkyl, C₁-C₁₄ alkyl, C₁-C₁₃ alkyl, C₁-C₁₂ alkyl, C₁-C₁₁ alkyl, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₈ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, or C₁-C₂ alkyl) optionally substituted with D or halogen.

In some embodiments of the compound of Formula (I-2), R_b represents the following group: CH₃, CF₃, CD₃, CH₂CH₃, —(CH₂)₂—CH₃, —(CH₂)₃—CH₃, —(CH₂)₄—CH₃, —(CH₂)₅—CH₃, —(CH₂)₆—CH₃, —(CH₂)₇—CH₃, —(CH₂)₈—CH₃, —(CH₂)₉—CH₃, —(CH₂)₁₀—CH₃, —(CH₂)₁₁—CH₃, —(CH₂)₁₂—CH₃, —(CH₂)₁₃—CH₃, —(CH₂)₁₄—CH₃, —(CH₂)₁₅—CH₃, —(CH₂)₁₆—CH₃, —(CH₂)₁₇—CH₃, —(CH₂)₁₈—CH₃, —(CH₂)₁₉—CH₃, —(CH₂)₂₀—CH₃, —(CH₂)₂₁—CH₃, —(CH₂)₂₂—CH₃, —(CH₂)₂₃—CH₃, —(CH₂)₂₄—CH₃, —(CH₂)₂₅—CH₃, —(CH₂)₂₆—CH₃, —(CH₂)₂₇—CH₃, —(CH₂)₂₈—CH₃, or —(CH₂)₂₉—CH₃.

In some embodiments of the compound of Formula (I-2), R_b represents the following formula:

R_b1—X₄-L₂-,

• • wherein L₂ represents:
    • linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof, or
    • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of C_3-15cycloalkylene, 4- to 15-membered heterocyclylene, C_6-10 arylene, 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene, C_6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof, and the linear or branched C_2-60 alkylene is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl (e.g., C_1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogen, C_3-6cycloalkyl or any combination thereof;
  • X₄ represents a bond, or X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted C_3-20cycloalkylene, optionally substituted C_6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, and the C_3-20cycloalkylene, the C_6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; and
  • R_b1 represents optionally substituted C_3-20cycloalkyl, optionally substituted C_6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C_3-20cycloalkyl, the C_6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-2), L₂ represents the structure of the following formula: —C_2-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl (e.g., C_1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (1-2), L₂ represents the following group:

• • —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₂—CF₂—(CH₂)₂—, —(CH₂)₆—, —(CH₂)₇—, —(CH₂)₈—, —(CH₂)₉—, —(CH₂)₁₀—, —(CH₂)₁₁—, —(CH₂)₁₂—, —(CH₂)₁₃—, —(CH₂)₁₄—, —(CH₂)₁₅—, —(CH₂)₁₆—, —(CH₂)₁₇—, —(CH₂)₁₈—, —(CH₂)₁₉—, —(CH₂)₂₀—, —(CH₂)₂₁—, —(CH₂)₂₂—, —(CH₂)₂₅—, or —(CH₂)₃₀—;
  • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ of the group is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl (e.g., C_1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (I-2), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—(R₁₂(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—(R₁₃(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₂—R₁₃—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃—R₁₂—(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each group R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R₁₄ independently represents H or C_1-3 alkyl; and each group R₁₃ is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-2), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—(O(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m1)_p1—(O(C(R^a13)(R^a14)_p2—(O(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—(N(R_g11)(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—(C(O)NH—(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—C(O)NH—(C(R^a11)(R^a12))_m2—(O(C(R^a13)(R^a14))_m3)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(NHC(O)N—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13(R^a14)_m3)_p2—(O—(C(R^a15(R^a16)_m4)_p3—;

—(C(R^a9)(R^a10))_m1—C(O)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—C(S)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—S—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—C_6-10 arylene-(C(R^a13)(R^a14))_m3—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1-(4- to 15-membered heterocyclylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1-(5- to 15-membered heteroarylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C_3-15 cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(C_3-15cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—(C_3-15cycloalkylene-(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each R_g11 independently represents H or C_1-3 alkyl;
  • the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-2), L₂ represents the structure of the following formula:

• • —CH₂—O—CH₂—, —CH₂—O—(CH₂)₂—, —(CH₂)₁—O—(CH₂)₃—, —(CH₂)₁—O—(CH₂)₄—, —(CH₂)₁—O—(CH₂)₅—, —(CH₂)₁—O—(CH₂)₆—, —(CH₂)₁—O—(CH₂)₇—, —(CH₂)₁—O—(CH₂)₈—, —(CH₂)₁—O—(CH₂)₉—, —(CH₂)₁—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁—, —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—O—(CH₂)₄—, —(CH₂)₂—O—(CH₂)₅—, —(CH₂)₂—O—(CH₂)₆—, —(CH₂)₂—O—(CH₂)₇—, —(CH₂)₂—O—(CH₂)₈—, —(CH₂)₂—O—(CH₂)₉—, —(CH₂)₂—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁₁—, —(CH₂)₂—O—(CH₂)₁₂—, —(CH₂)₃—O—(CH₂)₁—, —(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—O—(CH₂)₃—, —(CH₂)₃—O—(CH₂)₄—, —(CH₂)₃—O—(CH₂)₅—, —(CH₂)₃—O—(CH₂)₆—, —(CH₂)₃—O—(CH₂)₇—, —(CH₂)₄—O—(CH₂)₁—, —(CH₂)₄—O—(CH₂)₂—, —(CH₂)₄—O—(CH₂)₃—, —(CH₂)₄—O—(CH₂)₄—, —(CH₂)₄—O—(CH₂)₅—, —(CH₂)₄—O—(CH₂)₆—, —(CH₂)₅—O—(CH₂)₁—, —(CH₂)₅—O—(CH₂)₂—, —(CH₂)₅—O—(CH₂)₃—, —(CH₂)₅—O—(CH₂)₄—, —(CH₂)₅—O—(CH₂)₅—, —(CH₂)₆—O—(CH₂)₁—, —(CH₂)₆—O—(CH₂)₂—, —(CH₂)₆—O—(CH₂)₃—, —(CH₂)₆—O—(CH₂)₄—, —(CH₂)₇—O—(CH₂)₁—, —(CH₂)₇—O—(CH₂)₂—, —(CH₂)₇—O—(CH₂)₃—, —(CH₂)₈—O—(CH₂)₁—, —(CH₂)₈—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₁—, —CH(CH₃)—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₃—, —CH(CH₃)—O—(CH₂)₄—, —CH(CH₃)—O—(CH₂)₅—, —CH(CH₃)—O—(CH₂)₆—, —CH(CH₃)—O—(CH₂)₇—, —CH(CH₃)—O—(CH₂)₈—, —CH(CH₃)—O—(CH₂)₉—, —CH(CH₃)—O—(CH₂)₁₀—, —CH₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₂)₆—, —CH₂—(O(CH₂)₂)₇—, —CH₂—(O(CH₂)₂)₈—, —CH₂—(O(CH₂)₂)₉—, —CH₂—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₂)₁—OCH₂—, —CH₂—(O(CH₂)₂)₂—OCH₂—, —CH₂—(O(CH₂)₂)₃—OCH₂—, —CH₂—(O(CH₂)₂)₄—OCH₂—, —CH₂—(O(CH₂)₂)₅—OCH₂—, —CH₂—(O(CH₂)₂)₆—OCH₂—, —CH₂—(O(CH₂)₂)₇—OCH₂—, —CH₂—(O(CH₂)₂)₈—OCH₂—, —CH₂—(O(CH₂)₂)₉—OCH₂—, —CH₂—(O(CH₂)₂)₁₀—OCH₂—, —(CH₂)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₂)₆—, —(CH₂)₂—(O(CH₂)₂)₇—, —(CH₂)₂—(O(CH₂)₂)₈—, —(CH₂)₂—(O(CH₂)₂)₉—, —(CH₂)₂—(O(CH₂)₂)₁₀—, —(CH₂)₃—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₂)₆—, —(CH₂)₃—(O(CH₂)₂)₇—, —(CH₂)₃—(O(CH₂)₂)₈—, —(CH₂)₃—(O(CH₂)₂)₉—, —(CH₂)₃—(O(CH₂)₂)₁₀—, —(CH₂)₄—(O(CH₂)₂)₂—, —(CH₂)₄—(O(CH₂)₂)₃—, —(CH₂)₄—(O(CH₂)₂)₄—, —(CH₂)₄—(O(CH₂)₂)₅—, —(CH₂)₄—(O(CH₂)₂)₆—, —(CH₂)₄—(O(CH₂)₂)₇—, —(CH₂)₄—(O(CH₂)₂)₈—, —(CH₂)₄—(O(CH₂)₂)₉—, —(CH₂)₄—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₃)₆—, —CH₂—(O(CH₂)₃)₇—, —CH₂—(O(CH₂)₃)₈—, —CH₂—(O(CH₂)₃)₉—, —CH₂—(O(CH₂)₃)₁₀—, —(CH₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₃)₆—, —(CH₂)₂—(O(CH₂)₃)₇—, —(CH₂)₂—(O(CH₂)₃)₈—, —(CH₂)₂—(O(CH₂)₃)₉—, —(CH₂)₂—(O(CH₂)₃)₁₀—, —(CH₂)₃—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₃)₆—, —(CH₂)₃—(O(CH₂)₃)₇—, —(CH₂)₃—(O(CH₂)₃)₈—, —(CH₂)₃—(O(CH₂)₃)₉—, —(CH₂)₃—(O(CH₂)₃)₁₀—, —CH₂—O—(CH₂)₂—O—(CH₂)₃—, —CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —CH₂—O—(CH₂)₃—O—(CH₂)₂—, —CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —CH₂—O—(CH₂)₂—O—CH₂—, —(CH₂)₂—O—(CH₂)₂O—CH₂—, —(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, —CH₂—C(O)—CH₂—, —CH₂—C(O)—(CH₂)₂—, —(CH₂)₁—C(O)—(CH₂)₃—, —(CH₂)₁—C(O)—(CH₂)₄—, —(CH₂)₁—C(O)—(CH₂)₅—, —(CH₂)₁—C(O)—(CH₂)₆—, —(CH₂)₁—C(O)—(CH₂)₇—, —(CH₂)₁—C(O)—(CH₂)₈—, —(CH₂)₁—C(O)—(CH₂)₉—, —(CH₂)₁—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁—, —(CH₂)₂—C(O)—(CH₂)₂—, —(CH₂)₂—C(O)—(CH₂)₃—, —(CH₂)₂—C(O)—(CH₂)₄—, —(CH₂)₂—C(O)—(CH₂)₅—, —(CH₂)₂—C(O)—(CH₂)₆—, —(CH₂)₂—C(O)—(CH₂)₇—, —(CH₂)₂—C(O)—(CH₂)₈—, —(CH₂)₂—C(O)—(CH₂)₉—, —(CH₂)₂—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁₁—, —(CH₂)₂—C(O)—(CH₂)₁₂—, —(CH₂)₃—C(O)—(CH₂)₁—, —(CH₂)₃—C(O)—(CH₂)₂—, —(CH₂)₃—C(O)—(CH₂)₃—, —(CH₂)₃—C(O)—(CH₂)₄—, —(CH₂)₃—C(O)—(CH₂)₅—, —(CH₂)₃—C(O)—(CH₂)₆—, —(CH₂)₃—C(O)—(CH₂)₇—, —(CH₂)₄—C(O)—(CH₂)₁—, —(CH₂)₄—C(O)—(CH₂)₂—, —(CH₂)₄—C(O)—(CH₂)₃—, —(CH₂)₄—C(O)—(CH₂)₄—, —(CH₂)₄—C(O)—(CH₂)₅—, —(CH₂)₄—C(O)—(CH₂)₆—, —(CH₂)₅—C(O)—(CH₂)₁—, —(CH₂)₅—C(O)—(CH₂)₂—, —(CH₂)₅—C(O)—(CH₂)₃—, —(CH₂)₅—C(O)—(CH₂)₄—, —(CH₂)₅—C(O)—(CH₂)₅—, —(CH₂)₆—C(O)—(CH₂)₁—, —(CH₂)₆—C(O)—(CH₂)₂—, —(CH₂)₆—C(O)—(CH₂)₃—, —(CH₂)₆—C(O)—(CH₂)₄—, —(CH₂)₇—C(O)—(CH₂)₁—, —(CH₂)₇—C(O)—(CH₂)₂—, —(CH₂)₇—C(O)—(CH₂)₃—, —(CH₂)₈—C(O)—(CH₂)₁—, —(CH₂)₈—C(O)—(CH₂)₂—, —CH₂—S—CH₂—, —CH₂—S—(CH₂)₂—, —(CH₂)₁—S—(CH₂)₃—, —(CH₂)₁—S—(CH₂)₄—, —(CH₂)₁—S—(CH₂)₅—, —(CH₂)₁—S—(CH₂)₆—, —(CH₂)₁—S—(CH₂)₇—, —(CH₂)₁—S—(CH₂)₈—, —(CH₂)₁—S—(CH₂)₉—, —(CH₂)₁—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁—, —(CH₂)₂—S—(CH₂)₂—, —(CH₂)₂—S—(CH₂)₃—, —(CH₂)₂—S—(CH₂)₄—, —(CH₂)₂—S—(CH₂)₅—, —(CH₂)₂—S—(CH₂)₆—, —(CH₂)₂—S—(CH₂)₇—, —(CH₂)₂—S—(CH₂)₈—, —(CH₂)₂—S—(CH₂)₉—, —(CH₂)₂—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁₁—, —(CH₂)₂—S—(CH₂)₁₂—, —(CH₂)₃—S—(CH₂)₁—, —(CH₂)₃—S—(CH₂)₂—, —(CH₂)₃—S—(CH₂)₃—, —(CH₂)₃—S—(CH₂)₄—, —(CH₂)₃—S—(CH₂)₅—, —(CH₂)₃—S—(CH₂)₆—, —(CH₂)₃—S—(CH₂)₇—, —(CH₂)₄—S—(CH₂)₁—, —(CH₂)₄—S—(CH₂)₂—, —(CH₂)₄—S—(CH₂)₃—, —(CH₂)₄—S—(CH₂)₄—, —(CH₂)₄—S—(CH₂)₅—, —(CH₂)₄—S—(CH₂)₆—, —(CH₂)₅—S—(CH₂)₁—, —(CH₂)₅—S—(CH₂)₂—, —(CH₂)₅—S—(CH₂)₃—, —(CH₂)₅—S—(CH₂)₄—, —(CH₂)₅—S—(CH₂)₅—, —(CH₂)₆—S—(CH₂)₁—, —(CH₂)₆—S—(CH₂)₂—, —(CH₂)₆—S—(CH₂)₃—, —(CH₂)₆—S—(CH₂)₄—, —(CH₂)₇—S—(CH₂)₁—, —(CH₂)₇—S—(CH₂)₂—, —(CH₂)₇—S—(CH₂)₃—, —(CH₂)₈—S—(CH₂)₁—, —(CH₂)₈—S—(CH₂)₂—, —CH₂—C(S)—CH₂—, —CH₂—C(S)—(CH₂)₂—, —(CH₂)₁—C(S)—(CH₂)₃—, —(CH₂)₁—C(S)—(CH₂)₄—, —(CH₂)₁—C(S)—(CH₂)₅—, —(CH₂)₁—C(S)—(CH₂)₆—, —(CH₂)₁—C(S)—(CH₂)₇—, —(CH₂)₁—C(S)—(CH₂)₈—, —(CH₂)₁—C(S)—(CH₂)₉—, —(CH₂)₁—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁—, —(CH₂)₂—C(S)—(CH₂)₂—, —(CH₂)₂—C(S)—(CH₂)₃—, —(CH₂)₂—C(S)—(CH₂)₄—, —(CH₂)₂—C(S)—(CH₂)₅—, —(CH₂)₂—C(S)—(CH₂)₆—, —(CH₂)₂—C(S)—(CH₂)₇—, —(CH₂)₂—C(S)—(CH₂)₈—, —(CH₂)₂—C(S)—(CH₂)₉—, —(CH₂)₂—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁₁—, —(CH₂)₂—C(S)—(CH₂)₁₂—, —(CH₂)₃—C(S)—(CH₂)₁—, —(CH₂)₃—C(S)—(CH₂)₂—, —(CH₂)₃—C(S)—(CH₂)₃—, —(CH₂)₃—C(S)—(CH₂)₄—, —(CH₂)₃—C(S)—(CH₂)₅—, —(CH₂)₃—C(S)—(CH₂)₆—, —(CH₂)₃—C(S)—(CH₂)₇—, —(CH₂)₄—C(S)—(CH₂)₁—, —(CH₂)₄—C(S)—(CH₂)₂—, —(CH₂)₄—C(S)—(CH₂)₃—, —(CH₂)₄—C(S)—(CH₂)₄—, —(CH₂)₄—C(S)—(CH₂)₅—, —(CH₂)₄—C(S)—(CH₂)₆—, —(CH₂)₅—C(S)—(CH₂)₁—, —(CH₂)₅—C(S)—(CH₂)₂—, —(CH₂)₅—C(S)—(CH₂)₃—, —(CH₂)₅—C(S)—(CH₂)₄—, —(CH₂)₅—C(S)—(CH₂)₅—, —(CH₂)₆—C(S)—(CH₂)₁—, —(CH₂)₆—C(S)—(CH₂)₂—, —(CH₂)₆—C(S)—(CH₂)₃—, —(CH₂)₆—C(S)—(CH₂)₄—, —(CH₂)₇—C(S)—(CH₂)₁—, —(CH₂)₇—C(S)—(CH₂)₂—, —(CH₂)₇—C(S)—(CH₂)₃—, —(CH₂)₈—C(S)—(CH₂)₁—, —(CH₂)₈—C(S)—(CH₂)₂—, —CH₂—C(O)O—CH₂—, —CH₂—C(O)O—(CH₂)₂—, —(CH₂)₁—C(O)O—(CH₂)₃—, —(CH₂)₁—C(O)O—(CH₂)₄—, —(CH₂)₁—C(O)O—(CH₂)₅—, —(CH₂)₁—C(O)O—(CH₂)₆—, —(CH₂)₁—C(O)O—(CH₂)₇—, —(CH₂)₁—C(O)O—(CH₂)₈—, —(CH₂)₁—C(O)O—(CH₂)₉—, —(CH₂)₁—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁—, —(CH₂)₂—C(O)O—(CH₂)₂—, —(CH₂)₂—C(O)O—(CH₂)₃—, —(CH₂)₂—C(O)O—(CH₂)₄—, —(CH₂)₂—C(O)O—(CH₂)₅—, —(CH₂)₂—C(O)O—(CH₂)₆—, —(CH₂)₂—C(O)O—(CH₂)₇—, —(CH₂)₂—C(O)O—(CH₂)₈—, —(CH₂)₂—C(O)O—(CH₂)₉—, —(CH₂)₂—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁₁—, —(CH₂)₂—C(O)O—(CH₂)₁₂—, —(CH₂)₃—C(O)O—(CH₂)₁—, —(CH₂)₃—C(O)O—(CH₂)₂—, —(CH₂)₃—C(O)O—(CH₂)₃—, —(CH₂)₃—C(O)O—(CH₂)₄—, —(CH₂)₃—C(O)O—(CH₂)₅—, —(CH₂)₃—C(O)O—(CH₂)₆—, —(CH₂)₃—C(O)O—(CH₂)₇—, —(CH₂)₄—C(O)O—(CH₂)₁—, —(CH₂)₄—C(O)O—(CH₂)₂—, —(CH₂)₄—C(O)O—(CH₂)₃—, —(CH₂)₄—C(O)O—(CH₂)₄—, —(CH₂)₄—C(O)O—(CH₂)₅—, —(CH₂)₄—C(O)O—(CH₂)₆—, —(CH₂)₅—C(O)O—(CH₂)₁—, —(CH₂)₅—C(O)O—(CH₂)₂—, —(CH₂)₅—C(O)O—(CH₂)₃—, —(CH₂)₅—C(O)O—(CH₂)₄—, —(CH₂)₅—C(O)O—(CH₂)₅—, —(CH₂)₆—C(O)O—(CH₂)₁—, —(CH₂)₆—C(O)O—(CH₂)₂—, —(CH₂)₆—C(O)O—(CH₂)₃—, —(CH₂)₆—C(O)O—(CH₂)₄—, —(CH₂)₇—C(O)O—(CH₂)₁—, —(CH₂)₇—C(O)O—(CH₂)₂—, —(CH₂)₇—C(O)O—(CH₂)₃—, —(CH₂)₈—C(O)O—(CH₂)₁—, —(CH₂)₈—C(O)O—(CH₂)₂—, —CH₂—OC(O)—CH₂—, —CH₂—OC(O)—(CH₂)₂—, —(CH₂)₁—OC(O)—(CH₂)₃—, —(CH₂)₁—OC(O)—(CH₂)₄—, —(CH₂)₁—OC(O)—(CH₂)₅—, —(CH₂)₁—OC(O)—(CH₂)₆—, —(CH₂)₁—OC(O)—(CH₂)₇—, —(CH₂)₁—OC(O)—(CH₂)₈—, —(CH₂)₁—OC(O)—(CH₂)₉—, —(CH₂)₁—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁—, —(CH₂)₂—OC(O)—(CH₂)₂—, —(CH₂)₂—OC(O)—(CH₂)₃—, —(CH₂)₂—OC(O)—(CH₂)₄—, —(CH₂)₂—OC(O)—(CH₂)₅—, —(CH₂)₂—OC(O)—(CH₂)₆—, —(CH₂)₂—OC(O)—(CH₂)₇—, —(CH₂)₂—OC(O)—(CH₂)₈—, —(CH₂)₂—OC(O)—(CH₂)₉—, —(CH₂)₂—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁₁—, —(CH₂)₂—OC(O)—(CH₂)₁₂—, —(CH₂)₃—OC(O)—(CH₂)₁—, —(CH₂)₃—OC(O)—(CH₂)₂—, —(CH₂)₃—OC(O)—(CH₂)₃—, —(CH₂)₃—OC(O)—(CH₂)₄—, —(CH₂)₃—OC(O)—(CH₂)₅—, —(CH₂)₃—OC(O)—(CH₂)₆—, —(CH₂)₃—OC(O)—(CH₂)₇—, —(CH₂)₄—OC(O)—(CH₂)₁—, —(CH₂)₄—OC(O)—(CH₂)₂—, —(CH₂)₄—OC(O)—(CH₂)₃—, —(CH₂)₄—OC(O)—(CH₂)₄—, —(CH₂)₄—OC(O)—(CH₂)₅—, —(CH₂)₄—OC(O)—(CH₂)₆—, —(CH₂)₅—OC(O)—(CH₂)₁—, —(CH₂)₅—OC(O)—(CH₂)₂—, —(CH₂)₅—OC(O)—(CH₂)₃—, —(CH₂)₅—OC(O)—(CH₂)₄—, —(CH₂)₅—OC(O)—(CH₂)₅—, —(CH₂)₆—OC(O)—(CH₂)₁—, —(CH₂)₆—OC(O)—(CH₂)₂—, —(CH₂)₆—OC(O)—(CH₂)₃—, —(CH₂)₆—OC(O)—(CH₂)₄—, —(CH₂)₇—OC(O)—(CH₂)₁—, —(CH₂)₇—OC(O)—(CH₂)₂—, —(CH₂)₇—OC(O)—(CH₂)₃—, —(CH₂)₈—OC(O)—(CH₂)₁—, —(CH₂)₈—OC(O)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₁—, —(CH₂)₁—N(R_g11)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₃—, —(CH₂)₁—N(R_g11)—(CH₂)₄—, —(CH₂)₁—N(R_g11)—(CH₂)₅—, —(CH₂)₁—N(R_g11)—(CH₂)₆—, —(CH₂)₁—N(R_g11)—(CH₂)₇—, —(CH₂)₁—N(R_g11)—(CH₂)₈—, —(CH₂)₁—N(R_g11)—(CH₂)₉—, —(CH₂)₁—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₂—, —(CH₂)₂—N(R_g11)—(CH₂)₃—, —(CH₂)₂—N(R_g11)—(CH₂)₄—, —(CH₂)₂—N(R_g11)—(CH₂)₅—, —(CH₂)₂—N(R_g11)—(CH₂)₆—, —(CH₂)₂—N(R_g11)—(CH₂)₇—, —(CH₂)₂—N(R_g11)—(CH₂)₈—, —(CH₂)₂—N(R_g11)—(CH₂)₉—, —(CH₂)₂—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₁₂—, —(CH₂)₃—N(R_g11)—(CH₂)₁—, —(CH₂)₃—N(R_g11)—(CH₂)₂—, —(CH₂)₃—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₁—, —(CH₂)₄—N(R_g11)—(CH₂)₂—, —(CH₂)₄—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₄—, —(CH₂)₈—N(R_g11)—(CH₂)₁—, —(CH₂)₅—N(R_g11)—(CH₂)₂—, —(CH₂)₅—N(R_g11)—(CH₂)₃—, —(CH₂)₅—N(R_g11)—(CH₂)₄—, —(CH₂)₈—N(R_g11)—(CH₂)₅—, —(CH₂)₆—N(R_g11)—(CH₂)₁—, —(CH₂)₆—N(R_g11)—(CH₂)₂—, —(CH₂)₆—N(R_g11)—(CH₂)₃—, —(CH₂)₇—N(R_g11)—(CH₂)₁—, —(CH₂)₇—N(R_g11)—(CH₂)₂—, —(CH₂)₇—N(R_g11)—(CH₂)₃—, —(CH₂)₈—N(R_g11)—(CH₂)₁—, —(CH₂)₈—N(R_g11)—(CH₂)₂—, —(CH₂)₈—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₁—, —CH(CH₃)—N(R_g11)—(CH₂)₂—, —CH(CH₃)—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₄—, —CH(CH₃)—N(R_g11)—(CH₂)₅—, —CH(CH₃)—N(R_g11)—(CH₂)₆—, —CH(CH₃)—N(R_g11)—(CH₂)₇—, —CH(CH₃)—N(R_g11)—(CH₂)₈—, —CH(CH₃)—N(R_g11)—(CH₂)₉—, —CH(CH₃)—N(R_g11)—(CH₂)₁₀—, —CH₂C(O)NHCH₂—, —(CH₂)₂C(O)NH(CH₂)₂—, —(CH₂)₂C(O)NH(CH₂)₃—, —(CH₂)₂C(O)NH(CH₂)₄—, —(CH₂)₂C(O)NH(CH₂)₅—, —(CH₂)₃C(O)NH(CH₂)₃—, —(CH₂)₃C(O)NH(CH₂)₄—, —(CH₂)₄C(O)NH(CH₂)₄—, —(CH₂)₅C(O)NH(CH₂)₅—, —(CH₂)₆C(O)NH(CH₂)₇—, —(CH₂)₆C(O)NH(CH₂)₆—, —(CH₂)₇C(O)NH(CH₂)₇—, —(CH₂)₈C(O)NH(CH₂)₈, —(CH₂)₉C(O)NH(CH₂)₉—, —(CH₂)₁₀C(O)NH(CH₂)₁₀—, —(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, —CH₂NHC(O)CH₂—, —(CH₂)₂NHC(O)(CH₂)₂—, —(CH₂)₂NHC(O)(CH₂)₃—, —(CH₂)₂NHC(O)(CH₂)₄—, —(CH₂)₂NHC(O)(CH₂)₅—, —(CH₂)₃NHC(O)(CH₂)₃—, —(CH₂)₃NHC(O)(CH₂)₄—, —(CH₂)₄NHC(O)(CH₂)₄—, —(CH₂)₅NHC(O)(CH₂)₅—, —(CH₂)₆NHC(O)(CH₂)₇—, —(CH₂)₆NHC(O)(CH₂)₆—, —(CH₂)₇NHC(O)(CH₂)₇—, —(CH₂)₈NHC(O)(CH₂)₈, —(CH₂)₉NHC(O)(CH₂)₉—, —(CH₂)₁₀NHC(O)(CH₂)₁₀—, —(CH₂)₄NHC(O)(CH₂)₈—, —(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, —(CH₂)₄NHC(O)CH₂—, —CH₂-piperidinylene-CH₂—, —CH₂-piperidinylene-(CH₂)₂—, —CH₂-piperidinylene-(CH₂)₃—, —CH₂-piperidinylene-(CH₂)₄—, —CH₂-piperidinylene-(CH₂)₅—, —CH₂-piperidinylene-(CH₂)₆—, —CH₂-piperidinylene-(CH₂)₇—, —CH₂-piperidinylene-(CH₂)₈—, —(CH₂)₂-piperidinylene-(CH₂)₁—, —(CH₂)₂-piperidinylene-(CH₂)₂—, —(CH₂)₂-piperidinylene-(CH₂)₃—, —(CH₂)₂-piperidinylene-(CH₂)₄—, —(CH₂)₂-piperidinylene-(CH₂)₅—, —(CH₂)₂-piperidinylene-(CH₂)₆—, —(CH₂)₂-piperidinylene-(CH₂)₇—, —(CH₂)₂-piperidinylene-(CH₂)₈—, —(CH₂)₃-piperidinylene-CH₂—, —(CH₂)₃-piperidinylene-(CH₂)₂—, —(CH₂)₃-piperidinylene-(CH₂)₃—, —(CH₂)₃-piperidinylene-(CH₂)₄—, —(CH₂)₃-piperidinylene-(CH₂)₅—, —(CH₂)₃-piperidinylene-(CH₂)₆—, —(CH₂)₃-piperidinylene-(CH₂)₇—, —(CH₂)₃-piperidinylene-(CH₂)₈—, —(CH₂)₄-piperidinylene-CH₂—, —(CH₂)₄-piperidinylene-(CH₂)₂—, —(CH₂)₄-piperidinylene-(CH₂)₃—, —(CH₂)₄-piperidinylene-(CH₂)₄—, —(CH₂)₄-piperidinylene-(CH₂)₅—, —(CH₂)₄-piperidinylene-(CH₂)₆—, —(CH₂)₄-piperidinylene-(CH₂)₇—, —(CH₂)₄-piperidinylene-(CH₂)₈—, —(CH₂)₅-piperidinylene-(CH₂)₁—, —(CH₂)₅-piperidinylene-(CH₂)₂—, —(CH₂)₅-piperidinylene-(CH₂)₃—, —(CH₂)₅-piperidinylene-(CH₂)₄—, —(CH₂)₅-piperidinylene-(CH₂)₅—, —(CH₂)₅-piperidinylene-(CH₂)₆—, —(CH₂)₅-piperidinylene-(CH₂)₇—, —(CH₂)₅-piperidinylene-(CH₂)₈—, —(CH₂)₆-piperidinylene-(CH₂)₁—, —(CH₂)₆-piperidinylene-(CH₂)₂—, —(CH₂)₆-piperidinylene-(CH₂)₃—, —(CH₂)₆-piperidinylene-(CH₂)₄—, —(CH₂)₆-piperidinylene-(CH₂)₅—, —(CH₂)₆-piperidinylene-(CH₂)₆—, —(CH₂)₆-piperidinylene-(CH₂)₇—, —(CH₂)₆-piperidinylene-(CH₂)₈—, —(CH₂)₇-piperidinylene-(CH₂)₁—, —(CH₂)₇-piperidinylene-(CH₂)₂—, —(CH₂)₇-piperidinylene-(CH₂)₃—, —(CH₂)₇-piperidinylene-(CH₂)₄—, —(CH₂)₇-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-CH₂—, —(CH₂)₈-piperidinylene-(CH₂)₂—, —(CH₂)₈-piperidinylene-(CH₂)₃—, —(CH₂)₈-piperidinylene-(CH₂)₄—, —(CH₂)₈-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-(CH₂)₆—, —(CH₂)₈-piperidinylene-(CH₂)₇—, —(CH₂)₈-piperidinylene-(CH₂)₈—, —CH₂-piperazinylene-CH₂—, —CH₂-piperazinylene-(CH₂)₂—, —CH₂-piperazinylene-(CH₂)₃—, —CH₂-piperazinylene-(CH₂)₄—, —CH₂-piperazinylene-(CH₂)₅—, —CH₂-piperazinylene-(CH₂)₆—, —CH₂-piperazinylene-(CH₂)₇—, —CH₂-piperazinylene-(CH₂)₈—, —(CH₂)₂-piperazinylene-(CH₂)₁—, —(CH₂)₂-piperazinylene-(CH₂)₂—, —(CH₂)₂-piperazinylene-(CH₂)₃—, —(CH₂)₂-piperazinylene-(CH₂)₄—, —(CH₂)₂-piperazinylene-(CH₂)₅—, —(CH₂)₂-piperazinylene-(CH₂)₆—, —(CH₂)₂-piperazinylene-(CH₂)₇—, —(CH₂)₂-piperazinylene-(CH₂)₈—, —(CH₂)₃-piperazinylene-CH₂—, —(CH₂)₃-piperazinylene-(CH₂)₂—, —(CH₂)₃-piperazinylene-(CH₂)₃—, —(CH₂)₃-piperazinylene-(CH₂)₄—, —(CH₂)₃-piperazinylene-(CH₂)₅—, —(CH₂)₃-piperazinylene-(CH₂)₆—, —(CH₂)₃-piperazinylene-(CH₂)₇—, —(CH₂)₃-piperazinylene-(CH₂)₈—, —(CH₂)₄-piperazinylene-CH₂—, —(CH₂)₄-piperazinylene-(CH₂)₂—, —(CH₂)₄-piperazinylene-(CH₂)₃—, —(CH₂)₄-piperazinylene-(CH₂)₄—, —(CH₂)₄-piperazinylene-(CH₂)₅—, —(CH₂)₄-piperazinylene-(CH₂)₆—, —(CH₂)₄-piperazinylene-(CH₂)₇—, —(CH₂)₄-piperazinylene-(CH₂)₈—, —(CH₂)₅-piperazinylene-(CH₂)₁—, —(CH₂)₅-piperazinylene-(CH₂)₂—, —(CH₂)₅-piperazinylene-(CH₂)₃—, —(CH₂)₅-piperazinylene-(CH₂)₄—, —(CH₂)₅-piperazinylene-(CH₂)₅—, —(CH₂)₅-piperazinylene-(CH₂)₆—, —(CH₂)₅-piperazinylene-(CH₂)₇—, —(CH₂)₅-piperazinylene-(CH₂)₈—, —(CH₂)₆-piperazinylene-(CH₂)₁—, —(CH₂)₆-piperazinylene-(CH₂)₂—, —(CH₂)₆-piperazinylene-(CH₂)₃—, —(CH₂)₆-piperazinylene-(CH₂)₄—, —(CH₂)₆-piperazinylene-(CH₂)₅—, —(CH₂)₆-piperazinylene-(CH₂)₆—, —(CH₂)₆-piperazinylene-(CH₂)₇—, —(CH₂)₆-piperazinylene-(CH₂)₈—, —(CH₂)₇-piperazinylene-(CH₂)₁—, —(CH₂)₇-piperazinylene-(CH₂)₂—, —(CH₂)₇-piperazinylene-(CH₂)₃—, —(CH₂)₇-piperazinylene-(CH₂)₄—, —(CH₂)₇-piperazinylene-(CH₂)₈—, —(CH₂)₈-piperazinylene-CH₂—, —(CH₂)₈-piperazinylene-(CH₂)₂—, —(CH₂)₈-piperazinylene-(CH₂)₃—, —(CH₂)₈-piperazinylene-(CH₂)₄—, —(CH₂)₈-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-(CH₂)₆—, —(CH₂)₈-piperazinylene-(CH₂)₇—, —(CH₂)₈-piperazinylene-(CH₂)₈—, —CH₂-propylene-CH₂—, —CH₂-propylene-(CH₂)₂—, —CH₂-propylene-(CH₂)₃—, —CH₂-propylene-(CH₂)₄—, —CH₂-propylene-(CH₂)₅—, —CH₂-propylene-(CH₂)₆—, —CH₂-propylene-(CH₂)₇—, —CH₂-propylene-(CH₂)₈—, —(CH₂)₂-propylene-(CH₂)₁—, —(CH₂)₂-propylene-(CH₂)₂—, —(CH₂)₂-propylene-(CH₂)₃—, —(CH₂)₂-propylene-(CH₂)₄—, —(CH₂)₂-propylene-(CH₂)₅—, —(CH₂)₂-propylene-(CH₂)₆—, —(CH₂)₂-propylene-(CH₂)₇—, —(CH₂)₂-propylene-(CH₂)₈—, —(CH₂)₃-propylene-CH₂—, —(CH₂)₃-propylene-(CH₂)₂—, —(CH₂)₃-propylene-(CH₂)₃—, —(CH₂)₃-propylene-(CH₂)₄—, —(CH₂)₃-propylene-(CH₂)₅—, —(CH₂)₃-propylene-(CH₂)₆—, —(CH₂)₃-propylene-(CH₂)₇—, —(CH₂)₃-propylene-(CH₂)₈—, —(CH₂)₄-propylene-CH₂—, —(CH₂)₄-propylene-(CH₂)₂—, —(CH₂)₄-propylene-(CH₂)₃—, —(CH₂)₄-propylene-(CH₂)₄—, —(CH₂)₄-propylene-(CH₂)₅—, —(CH₂)₄-propylene-(CH₂)₆—, —(CH₂)₄-propylene-(CH₂)₇—, —(CH₂)₄-propylene-(CH₂)₈—, —(CH₂)₅-propylene-(CH₂)₁—, —(CH₂)₅-propylene-(CH₂)₂—, —(CH₂)₅-propylene-(CH₂)₃—, —(CH₂)₅-propylene-(CH₂)₄—, —(CH₂)₅-propylene-(CH₂)₅—, —(CH₂)₅-propylene-(CH₂)₆—, —(CH₂)₅-propylene-(CH₂)₇—, —(CH₂)₅-propylene-(CH₂)₈—, —(CH₂)₆-propylene-(CH₂)₁—, —(CH₂)₆-propylene-(CH₂)₂—, —(CH₂)₆-propylene-(CH₂)₃—, —(CH₂)₆-propylene-(CH₂)₄—, —(CH₂)₆-propylene-(CH₂)₅—, —(CH₂)₆-propylene-(CH₂)₆—, —(CH₂)₆-propylene-(CH₂)₇—, —(CH₂)₆-propylene-(CH₂)₈—, —(CH₂)₇-propylene-(CH₂)₁—, —(CH₂)₇-propylene-(CH₂)₂—, —(CH₂)₇-propylene-(CH₂)₃—, —(CH₂)₇-propylene-(CH₂)₄—, —(CH₂)₇-propylene-(CH₂)₈—, —(CH₂)₈-propylene-CH₂—, —(CH₂)₈-propylene-(CH₂)₂—, —(CH₂)₈-propylene-(CH₂)₃—, —(CH₂)₈-propylene-(CH₂)₄—, —(CH₂)₈-propylene-(CH₂)₅—, —(CH₂)₈-propylene-(CH₂)₆—, —(CH₂)₈-propylene-(CH₂)₇—, —(CH₂)₈-propylene-(CH₂)₈—, —CH₂-diazacycloheptanylene-CH₂—, —CH₂-diazacycloheptanylene-(CH₂)₂—, —CH₂-diazacycloheptanylene-(CH₂)₃—, —CH₂-diazacycloheptanylene-(CH₂)₄—, —CH₂-diazacycloheptanylene-(CH₂)₅—, —CH₂-diazacycloheptanylene-(CH₂)₆—, —CH₂-diazacycloheptanylene-(CH₂)₇—, —CH₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₃-diazacycloheptanylene-CH₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₄-diazacycloheptanylene-CH₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-CH₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.2.1]octylene-CH₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.2]octylene-CH₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₈—;
  • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof; and
  • each R_g11 independently represents H or C_1-3 alkyl.

In some embodiments of the compound of Formula (I-2), L₂ represents the structure of the following formula:

In some embodiments of the compound of Formula (I-2), R_b1 represents:

• • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-2), R_b1 represents:

In some embodiments, the compound of Formula (I) is also of Formula (I-3):

• • wherein R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_b, (R_1a)_n, R_a, R_1a and n are as defined in the compound of Formula (I) above and the embodiments thereof;
  • wherein R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents N(R₁), O, S, alkynylene, or alkenylene, wherein R₁ represents H or C_1-3 alkyl, or X₁ represents a bond;
  • L₁ represents optionally substituted linear or branched C_1-60 alkylene (e.g., C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₅ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁ alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₈ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene);
  • X₂ represents N(R₂), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH—, —NH-triazolylene, or optionally substituted phenylene, wherein R₂ represents H or C_1-3 alkyl, or X₂ represents a bond; and
  • R_a1 represents hydroxy, optionally substituted adamantanyl, optionally substituted noradamantanyl, optionally substituted cubanyl, optionally substituted spirocycloalkyl, optionally substituted bicyclo[2.2.2]octan-1-yl, optionally substituted bicyclo[2.2.2]octan-2-yl, optionally substituted bornyl, optionally substituted bicyclo[2.2.1]heptanyl, optionally substituted bicyclo[2.2.1]heptenyl, optionally substituted p-menthanyl or optionally substituted m-menthanyl, wherein when R_a1 represents hydroxy, X₂ represents a bond;
  • and
  • R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkyl, C₁-C₂₉ alkyl, C₁-C₂₈ alkyl, C₁-C₂₇ alkyl, C₁-C₂₆ alkyl, C₁-C₂₅ alkyl, C₁-C₂₄ alkyl, C₁-C₂₃ alkyl, C₁-C₂₂ alkyl, C₁-C₂₁ alkyl, C₁-C₂₀ alkyl, C₁-C₁₉ alkyl, C₁-C₁₈ alkyl, C₁-C₁₇ alkyl, C₁-C₁₆ alkyl, C₁-C₁₅ alkyl, C₁-C₁₄ alkyl, C₁-C₁₃ alkyl, C₁-C₁₂ alkyl, C₁-C₁₁ alkyl, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₈ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, or C₁-C₂ alkyl) optionally substituted with D or halogen, or
  • R_b represents the following formula:

R_b1—X₄-L₂-,

• • • wherein L₂ represents:
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene), or
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), arylene (e.g., C_6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene, arylene and the heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
      • X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted arylene (e.g., optionally substituted C_6-20 arylene, or optionally substituted C_6-10 arylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), triazolylene-NH—, or —NH— triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, or X₄ represents a bond; and
      • R_b1 represents optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl, or optionally substituted C_6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 4- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl).

In some embodiments of the compound of Formula (I-3), R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents a bond, or X₁ represents N(R₁), O, S, C_2-6 alkynylene or C_2-6 alkenylene, wherein R₁ represents H or C_1-3 alkyl;
  • L₁ represents linear or branched C_1-60 alkylene (e.g., C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₈ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₅ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene) optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy, or any combination thereof;
  • X₂ represents a bond, or X₂ represents N(R₂), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH—, —NH— triazolylene, or optionally substituted phenylene, wherein R₂ represents H or C_1-3 alkyl, and the 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms is optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl, oxo, hydroxy, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano, or any combination thereof, and the phenylene is optionally substituted with 1 to 4 substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano, or any combination thereof; and R_a1 represents hydroxy, optionally substituted adamantanyl, optionally substituted noradamantanyl, optionally substituted cubanyl, optionally substituted spirocycloalkyl (e.g., optionally substituted C_5-20 spirocycloalkyl or optionally substituted C_6-15 spirocycloalkyl), optionally substituted bicyclo[2.2.2]octan-1-yl, optionally substituted bicyclo[2.2.2]octan-2-yl, optionally substituted bornyl, optionally substituted bicyclo[2.2.1]heptanyl, optionally substituted bicyclo[2.2.1]heptenyl, optionally substituted p-menthanyl or optionally substituted m-menthanyl, wherein when R_a1 represents hydroxy, X₂ represents a bond, and the adamantanyl, noradamantanyl, cubanyl, spirocycloalkyl, bicyclo[2.2.2]octan-1-yl, bicyclo[2.2.2]octan-2-yl, bornyl, bicyclo[2.2.1]heptanyl, bicyclo[2.2.1]heptenyl, p-menthanyl and m-menthanyl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-3), R_a1 represents hydroxy, and X₂ represents a bond.

In some embodiments of the compound of Formula (I-3), R_a1 represents:

• • adamantan-1-yl, adamantan-2-yl, adamantan-3-yl, adamantan-4-yl, adamantan-5-yl, adamantan-6-yl, adamantan-7-yl, adamantan-8-yl, adamantan-9-yl, adamantan-10-yl, noradamantan-1-yl, noradamantan-2-yl, noradamantan-3-yl, noradamantan-4-yl, noradamantan-5-yl, noradamantan-6-yl, noradamantan-7-yl, noradamantan-8-yl, noradamantan-9-yl, cubanyl, C_5-15 spirocycloalkyl, bicyclo[2.2.2]octan-1-yl, bicyclo[2.2.2]octan-2-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-3-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-4-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-5-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-6-yl,

bicyclo[2.2.1]hept-2-yl, bicyclo[2.2.1]hept-3-yl, bicyclo[2.2.1]hept-4-yl, bicyclo[2.2.1]hept-5-yl, bicyclo[2.2.1]hept-6-yl, bicyclo[2.2.1]hept-5-en-2-yl, bicyclo[2.2.1]hept-5-en-3-yl, bicyclo[2.2.1]hept-5-en-7-yl, 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl, 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-3-yl, 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-4-yl, 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-5-yl, 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-6-yl, p-menthanyl or m-menthanyl, with each group being independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-3), R_a1 represents:

In some embodiments of the compound of Formula (I-3), L₁ represents the structure of the following formula: ##—C_1-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_1-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (1-3), L₁ represents the following group: ##—CH₂—, ##—(CH₂)₂—, ##—(CH₂)₃—, ##—(CH₂)₄—, ##—(CH₂)₅—, ##—(CH₂)₂—CF₂—(CH₂)₂—, ##—(CH₂)₆—, ##—(CH₂)₇—, ##—(CH₂)₈—, ##—(CH₂)₉—, ##—(CH₂)₁₀—, ##—(CH₂)₁₁—, ##—(CH₂)₁₂—, ##—(CH₂)₁₃—, ##—(CH₂)₁₄—, ##—(CH₂)₁₅—, ##—(CH₂)₁₆—, ##—(CH₂)₁₇—, ##—(CH₂)₁₈—, ##—(CH₂)₁₉—, ##—(CH₂)₂₀—, ##—(CH₂)₁₂—, ##—(CH₂)₂₂—, ##—(CH₂)₂₅—, or ##—(CH₂)₃₀—;

• • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (1-3), R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkyl, C₁-C₂₉ alkyl, C₁-C₂₈ alkyl, C₁-C₂₇ alkyl, C₁-C₂₆ alkyl, C₁-C₂₅ alkyl, C₁-C₂₄ alkyl, C₁-C₂₃ alkyl, C₁-C₂₂ alkyl, C₁-C₂₁ alkyl, C₁-C₂₀ alkyl, C₁-C₁₉ alkyl, C₁-C₁₈ alkyl, C₁-C₁₇ alkyl, C₁-C₁₆ alkyl, C₁-C₁₅ alkyl, C₁-C₁₄ alkyl, C₁-C₁₃ alkyl, C₁-C₁₂ alkyl, C₁-C₁₁ alkyl, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₈ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, or C₁-C₂ alkyl) optionally substituted with D or halogen.

In some embodiments of the compound of Formula (1-3), R_b represents the following group: CH₃, CF₃, CD₃, CH₂CH₃, —(CH₂)₂—CH₃, —(CH₂)₃—CH₃, —(CH₂)₄—CH₃, —(CH₂)₅—CH₃, —(CH₂)₆—CH₃, —(CH₂)₇—CH₃, —(CH₂)₈—CH₃, —(CH₂)₉—CH₃, —(CH₂)₁₀—CH₃, —(CH₂)₁₁—CH₃, —(CH₂)₁₂—CH₃, —(CH₂)₁₃—CH₃, —(CH₂)₁₄—CH₃, —(CH₂)₁₅—CH₃, —(CH₂)₁₆—CH₃, —(CH₂)₁₇—CH₃, —(CH₂)₁₈—CH₃, —(CH₂)₁₉—CH₃, —(CH₂)₂₀—CH₃, —(CH₂)₂₁—CH₃, —(CH₂)₂₂—CH₃, —(CH₂)₂₃—CH₃, —(CH₂)₂₄—CH₃, —(CH₂)₂₅—CH₃, —(CH₂)₂₆—CH₃, —(CH₂)₂₇—CH₃, —(CH₂)₂₈—CH₃, or —(CH₂)₂₉—CH₃.

In some embodiments of the compound of Formula (I-3), R_b represents the following formula:

R_b1—X₄-L₂-,

• • wherein L₂ represents:
    • linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof, or
    • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of C_3-15cycloalkylene, 4- to 15-membered heterocyclylene, C_6-10 arylene, 5- to 15-membered heteroarylene or any combination thereof, wherein the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene, C_6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂- and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof, and the linear or branched C_2-60 alkylene is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl (e.g., C_1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), halogen, C_3-6cycloalkyl or any combination thereof;
  • X₄ represents a bond, or X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted C_3-20cycloalkylene, optionally substituted C_6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, and the C_3-20cycloalkylene, the C_6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; and
  • R_b1 represents optionally substituted C_3-20cycloalkyl, optionally substituted C_6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C_3-20cycloalkyl, the C_6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-3), L₂ represents the structure of the following formula: —C_2-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (1-3), L₂ represents the following group:

• • —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₂—CF₂—(CH₂)₂—, —(CH₂)₆—, —(CH₂)₇—, —(CH₂)₈—, —(CH₂)₉—, —(CH₂)₁₀—, —(CH₂)₁₁—, —(CH₂)₁₂—, —(CH₂)₁₃—, —(CH₂)₁₄—, —(CH₂)₁₅—, —(CH₂)₁₆—, —(CH₂)₁₇—, —(CH₂)₁₈—, —(CH₂)₁₉—, —(CH₂)₂₀—, —(CH₂)₂₁—, —(CH₂)₂₂—, —(CH₂)₂₅—, or —(CH₂)₃₀—;
  • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the group is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (I-3), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—(R₁₂(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—(R₁₃(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₂—R₁₃—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃—R₁₂—(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each group R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R₁₄ independently represents H or C_1-3 alkyl; and each group R₁₃ is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-3), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1(O(C(R^a11)(R^a12))_m2)_p1;

—(C(R^a9)(R^a10))_m1(O(C(R^a11)(R^a12))_m2)_p1—(O(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—(O(C(R^a13)(R^a14))_m3)_p2—(O(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—(N(R_g11)(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—(C(O)NH—(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—C(O)NH—(C(R^a11)(R^a12))_m2—(O(C(R^a13)(R^a14))_m3)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC)—C((R^a11)(R^a12))_m2)_p1;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—(O—(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—NHC(O)—(C(R^a11)(R^a12))_m2—(O(C(R^a13)(R^a14))_m3)_p1—;

—(C(R^a9)(R^a10))_m1—NHC(O)NH—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—C(O)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—C(S)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—S—(C(R^a11)(R^a2))_m2;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—C_6-10 arylene-(C(R^a13)(R^a14))_m3—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1—(4- to 15-membered heterocyclylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1—(5- to 15-membered heteroarylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C_3-15cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(C_3-15cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—(C_3-15cycloalkylene-(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each R_g11 independently represents H or C_1-3 alkyl;
  • the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-3), L₂ represents the structure of the following formula:

• • —CH₂—O—CH₂—, —CH₂—O—(CH₂)₂—, —(CH₂)₁—O—(CH₂)₃—, —(CH₂)₁—O—(CH₂)₄—, —(CH₂)₁—O—(CH₂)₅—, —(CH₂)₁—O—(CH₂)₆—, —(CH₂)₁—O—(CH₂)₇—, —(CH₂)₁—O—(CH₂)₈—, —(CH₂)₁—O—(CH₂)₉—, —(CH₂)₁—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁—, —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—O—(CH₂)₄—, —(CH₂)₂—O—(CH₂)₅—, —(CH₂)₂—O—(CH₂)₆—, —(CH₂)₂—O—(CH₂)₇—, —(CH₂)₂—O—(CH₂)₈—, —(CH₂)₂—O—(CH₂)₉—, —(CH₂)₂—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁₁—, —(CH₂)₂—O—(CH₂)₁₂—, —(CH₂)₃—O—(CH₂)₁—, —(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—O—(CH₂)₃—, —(CH₂)₃—O—(CH₂)₄—, —(CH₂)₃—O—(CH₂)₅—, —(CH₂)₃—O—(CH₂)₆—, —(CH₂)₃—O—(CH₂)₇—, —(CH₂)₄—O—(CH₂)₁—, —(CH₂)₄—O—(CH₂)₂—, —(CH₂)₄—O—(CH₂)₃—, —(CH₂)₄—O—(CH₂)₄—, —(CH₂)₄—O—(CH₂)₅—, —(CH₂)₄—O—(CH₂)₆—, —(CH₂)₅—O—(CH₂)₁—, —(CH₂)₅—O—(CH₂)₂—, —(CH₂)₅—O—(CH₂)₃—, —(CH₂)₅—O—(CH₂)₄—, —(CH₂)₅—O—(CH₂)₅—, —(CH₂)₆—O—(CH₂)₁—, —(CH₂)₆—O—(CH₂)₂—, —(CH₂)₆—O—(CH₂)₃—, —(CH₂)₆—O—(CH₂)₄—, —(CH₂)₇—O—(CH₂)₁—, —(CH₂)₇—O—(CH₂)₂—, —(CH₂)₇—O—(CH₂)₃—, —(CH₂)₈—O—(CH₂)₁—, —(CH₂)₈—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₁—, —CH(CH₃)—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₃—, —CH(CH₃)—O—(CH₂)₄—, —CH(CH₃)—O—(CH₂)₅—, —CH(CH₃)—O—(CH₂)₆—, —CH(CH₃)—O—(CH₂)₇—, —CH(CH₃)—O—(CH₂)₈—, —CH(CH₃)—O—(CH₂)₉—, —CH(CH₃)—O—(CH₂)₁₀—, —CH₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₂)₆—, —CH₂—(O(CH₂)₂)₇—, —CH₂—(O(CH₂)₂)₈—, —CH₂—(O(CH₂)₂)₉—, —CH₂—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₂)₁—OCH₂—, —CH₂—(O(CH₂)₂)₂—OCH₂—, —CH₂—(O(CH₂)₂)₃—OCH₂—, —CH₂—(O(CH₂)₂)₄—OCH₂—, —CH₂—(O(CH₂)₂)₅—OCH₂—, —CH₂—(O(CH₂)₂)₆—OCH₂—, —CH₂—(O(CH₂)₂)₇—OCH₂—, —CH₂—(O(CH₂)₂)₈—OCH₂—, —CH₂—(O(CH₂)₂)₉—OCH₂—, —CH₂—(O(CH₂)₂)₁₀—OCH₂—, —(CH₂)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₂)₆—, —(CH₂)₂—(O(CH₂)₂)₇—, —(CH₂)₂—(O(CH₂)₂)₈—, —(CH₂)₂—(O(CH₂)₂)₉—, —(CH₂)₂—(O(CH₂)₂)₁₀—, —(CH₂)₃—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₂)₆—, —(CH₂)₃—(O(CH₂)₂)₇—, —(CH₂)₃—(O(CH₂)₂)₈—, —(CH₂)₃—(O(CH₂)₂)₉—, —(CH₂)₃—(O(CH₂)₂)₁₀—, —(CH₂)₄—(O(CH₂)₂)₂—, —(CH₂)₄—(O(CH₂)₂)₃—, —(CH₂)₄—(O(CH₂)₂)₄—, —(CH₂)₄—(O(CH₂)₂)₅—, —(CH₂)₄—(O(CH₂)₂)₆—, —(CH₂)₄—(O(CH₂)₂)₇—, —(CH₂)₄—(O(CH₂)₂)₈—, —(CH₂)₄—(O(CH₂)₂)₉—, —(CH₂)₄—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₃)₆—, —CH₂—(O(CH₂)₃)₇—, —CH₂—(O(CH₂)₃)₈—, —CH₂—(O(CH₂)₃)₉—, —CH₂—(O(CH₂)₃)₁₀—, —(CH₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₃)₆—, —(CH₂)₂—(O(CH₂)₃)₇—, —(CH₂)₂—(O(CH₂)₃)₈—, —(CH₂)₂—(O(CH₂)₃)₉—, —(CH₂)₂—(O(CH₂)₃)₁₀—, —(CH₂)₃—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₃)₆—, —(CH₂)₃—(O(CH₂)₃)₇—, —(CH₂)₃—(O(CH₂)₃)₈—, —(CH₂)₃—(O(CH₂)₃)₉—, —(CH₂)₃—(O(CH₂)₃)₁₀—, —CH₂—O—(CH₂)₂—O—(CH₂)₃—, —CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —CH₂—O—(CH₂)₃—O—(CH₂)₂—, —CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —CH₂—O—(CH₂)₂—O—CH₂—, —(CH₂)₂—O—(CH₂)₂O—CH₂—, —(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, —CH₂—C(O)—CH₂—, —CH₂—C(O)—(CH₂)₂—, —(CH₂)₁—C(O)—(CH₂)₃—, —(CH₂)₁—C(O)—(CH₂)₄—, —(CH₂)₁—C(O)—(CH₂)₅—, —(CH₂)₁—C(O)—(CH₂)₆—, —(CH₂)₁—C(O)—(CH₂)₇—, —(CH₂)₁—C(O)—(CH₂)₈—, —(CH₂)₁—C(O)—(CH₂)₉—, —(CH₂)₁—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁—, —(CH₂)₂—C(O)—(CH₂)₂—, —(CH₂)₂—C(O)—(CH₂)₃—, —(CH₂)₂—C(O)—(CH₂)₄—, —(CH₂)₂—C(O)—(CH₂)₅—, —(CH₂)₂—C(O)—(CH₂)₆—, —(CH₂)₂—C(O)—(CH₂)₇—, —(CH₂)₂—C(O)—(CH₂)₈—, —(CH₂)₂—C(O)—(CH₂)₉—, —(CH₂)₂—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁₁—, —(CH₂)₂—C(O)—(CH₂)₁₂—, —(CH₂)₃—C(O)—(CH₂)₁—, —(CH₂)₃—C(O)—(CH₂)₂—, —(CH₂)₃—C(O)—(CH₂)₃—, —(CH₂)₃—C(O)—(CH₂)₄—, —(CH₂)₃—C(O)—(CH₂)₅—, —(CH₂)₃—C(O)—(CH₂)₆—, —(CH₂)₃—C(O)—(CH₂)₇—, —(CH₂)₄—C(O)—(CH₂)₁—, —(CH₂)₄—C(O)—(CH₂)₂—, —(CH₂)₄—C(O)—(CH₂)₃—, —(CH₂)₄—C(O)—(CH₂)₄—, —(CH₂)₄—C(O)—(CH₂)₅—, —(CH₂)₄—C(O)—(CH₂)₆—, —(CH₂)₅—C(O)—(CH₂)₁—, —(CH₂)₅—C(O)—(CH₂)₂—, —(CH₂)₅—C(O)—(CH₂)₃—, —(CH₂)₅—C(O)—(CH₂)₄—, —(CH₂)₅—C(O)—(CH₂)₅—, —(CH₂)₆—C(O)—(CH₂)₁—, —(CH₂)₆—C(O)—(CH₂)₂—, —(CH₂)₆—C(O)—(CH₂)₃—, —(CH₂)₆—C(O)—(CH₂)₄—, —(CH₂)₇—C(O)—(CH₂)₁—, —(CH₂)₇—C(O)—(CH₂)₂—, —(CH₂)₇—C(O)—(CH₂)₃—, —(CH₂)₈—C(O)—(CH₂)₁—, —(CH₂)₈—C(O)—(CH₂)₂—, —CH₂—S—CH₂—, —CH₂—S—(CH₂)₂—, —(CH₂)₁—S—(CH₂)₃—, —(CH₂)₁—S—(CH₂)₄—, —(CH₂)₁—S—(CH₂)₅—, —(CH₂)₁—S—(CH₂)₆—, —(CH₂)₁—S—(CH₂)₇—, —(CH₂)₁—S—(CH₂)₈—, —(CH₂)₁—S—(CH₂)₉—, —(CH₂)₁—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁—, —(CH₂)₂—S—(CH₂)₂—, —(CH₂)₂—S—(CH₂)₃—, —(CH₂)₂—S—(CH₂)₄—, —(CH₂)₂—S—(CH₂)₅—, —(CH₂)₂—S—(CH₂)₆—, —(CH₂)₂—S—(CH₂)₇—, —(CH₂)₂—S—(CH₂)₈—, —(CH₂)₂—S—(CH₂)₉—, —(CH₂)₂—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁₁—, —(CH₂)₂—S—(CH₂)₁₂—, —(CH₂)₃—S—(CH₂)₁—, —(CH₂)₃—S—(CH₂)₂—, —(CH₂)₃—S—(CH₂)₃—, —(CH₂)₃—S—(CH₂)₄—, —(CH₂)₃—S—(CH₂)₅—, —(CH₂)₃—S—(CH₂)₆—, —(CH₂)₃—S—(CH₂)₇—, —(CH₂)₄—S—(CH₂)₁—, —(CH₂)₄—S—(CH₂)₂—, —(CH₂)₄—S—(CH₂)₃—, —(CH₂)₄—S—(CH₂)₄—, —(CH₂)₄—S—(CH₂)₅—, —(CH₂)₄—S—(CH₂)₆—, —(CH₂)₅—S—(CH₂)₁—, —(CH₂)₅—S—(CH₂)₂—, —(CH₂)₅—S—(CH₂)₃—, —(CH₂)₅—S—(CH₂)₄—, —(CH₂)₅—S—(CH₂)₅—, —(CH₂)₆—S—(CH₂)₁—, —(CH₂)₆—S—(CH₂)₂—, —(CH₂)₆—S—(CH₂)₃—, —(CH₂)₆—S—(CH₂)₄—, —(CH₂)₇—S—(CH₂)₁—, —(CH₂)₇—S—(CH₂)₂—, —(CH₂)₇—S—(CH₂)₃—, —(CH₂)₈—S—(CH₂)₁—, —(CH₂)₈—S—(CH₂)₂—, —CH₂—C(S)—CH₂—, —CH₂—C(S)—(CH₂)₂—, —(CH₂)₁—C(S)—(CH₂)₃—, —(CH₂)₁—C(S)—(CH₂)₄—, —(CH₂)₁—C(S)—(CH₂)₅—, —(CH₂)₁—C(S)—(CH₂)₆—, —(CH₂)₁—C(S)—(CH₂)₇—, —(CH₂)₁—C(S)—(CH₂)₈—, —(CH₂)₁—C(S)—(CH₂)₉—, —(CH₂)₁—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁—, —(CH₂)₂—C(S)—(CH₂)₂—, —(CH₂)₂—C(S)—(CH₂)₃—, —(CH₂)₂—C(S)—(CH₂)₄—, —(CH₂)₂—C(S)—(CH₂)₅—, —(CH₂)₂—C(S)—(CH₂)₆—, —(CH₂)₂—C(S)—(CH₂)₇—, —(CH₂)₂—C(S)—(CH₂)₈—, —(CH₂)₂—C(S)—(CH₂)₉—, —(CH₂)₂—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁₁—, —(CH₂)₂—C(S)—(CH₂)₁₂—, —(CH₂)₃—C(S)—(CH₂)₁—, —(CH₂)₃—C(S)—(CH₂)₂—, —(CH₂)₃—C(S)—(CH₂)₃—, —(CH₂)₃—C(S)—(CH₂)₄—, —(CH₂)₃—C(S)—(CH₂)₅—, —(CH₂)₃—C(S)—(CH₂)₆—, —(CH₂)₃—C(S)—(CH₂)₇—, —(CH₂)₄—C(S)—(CH₂)₁—, —(CH₂)₄—C(S)—(CH₂)₂—, —(CH₂)₄—C(S)—(CH₂)₃—, —(CH₂)₄—C(S)—(CH₂)₄—, —(CH₂)₄—C(S)—(CH₂)₅—, —(CH₂)₄—C(S)—(CH₂)₆—, —(CH₂)₅—C(S)—(CH₂)₁—, —(CH₂)₅—C(S)—(CH₂)₂—, —(CH₂)₅—C(S)—(CH₂)₃—, —(CH₂)₅—C(S)—(CH₂)₄—, —(CH₂)₅—C(S)—(CH₂)₅—, —(CH₂)₆—C(S)—(CH₂)₁—, —(CH₂)₆—C(S)—(CH₂)₂—, —(CH₂)₆—C(S)—(CH₂)₃—, —(CH₂)₆—C(S)—(CH₂)₄—, —(CH₂)₇—C(S)—(CH₂)₁—, —(CH₂)₇—C(S)—(CH₂)₂—, —(CH₂)₇—C(S)—(CH₂)₃—, —(CH₂)₈—C(S)—(CH₂)₁—, —(CH₂)₈—C(S)—(CH₂)₂—, —CH₂—C(O)O—CH₂—, —CH₂—C(O)O—(CH₂)₂—, —(CH₂)₁—C(O)O—(CH₂)₃—, —(CH₂)₁—C(O)O—(CH₂)₄—, —(CH₂)₁—C(O)O—(CH₂)₅—, —(CH₂)₁—C(O)O—(CH₂)₆—, —(CH₂)₁—C(O)O—(CH₂)₇—, —(CH₂)₁—C(O)O—(CH₂)₈—, —(CH₂)₁—C(O)O—(CH₂)₉—, —(CH₂)₁—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁—, —(CH₂)₂—C(O)O—(CH₂)₂—, —(CH₂)₂—C(O)O—(CH₂)₃—, —(CH₂)₂—C(O)O—(CH₂)₄—, —(CH₂)₂—C(O)O—(CH₂)₅—, —(CH₂)₂—C(O)O—(CH₂)₆—, —(CH₂)₂—C(O)O—(CH₂)₇—, —(CH₂)₂—C(O)O—(CH₂)₈—, —(CH₂)₂—C(O)O—(CH₂)₉—, —(CH₂)₂—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁₁—, —(CH₂)₂—C(O)O—(CH₂)₁₂—, —(CH₂)₃—C(O)O—(CH₂)₁—, —(CH₂)₃—C(O)O—(CH₂)₂—, —(CH₂)₃—C(O)O—(CH₂)₃—, —(CH₂)₃—C(O)O—(CH₂)₄—, —(CH₂)₃—C(O)O—(CH₂)₅—, —(CH₂)₃—C(O)O—(CH₂)₆—, —(CH₂)₃—C(O)O—(CH₂)₇—, —(CH₂)₄—C(O)O—(CH₂)₁—, —(CH₂)₄—C(O)O—(CH₂)₂—, —(CH₂)₄—C(O)O—(CH₂)₃—, —(CH₂)₄—C(O)O—(CH₂)₄—, —(CH₂)₄—C(O)O—(CH₂)₅—, —(CH₂)₄—C(O)O—(CH₂)₆—, —(CH₂)₅—C(O)O—(CH₂)₁—, —(CH₂)₅—C(O)O—(CH₂)₂—, —(CH₂)₅—C(O)O—(CH₂)₃—, —(CH₂)₅—C(O)O—(CH₂)₄—, —(CH₂)₅—C(O)O—(CH₂)₅—, —(CH₂)₆—C(O)O—(CH₂)₁—, —(CH₂)₆—C(O)O—(CH₂)₂—, —(CH₂)₆—C(O)O—(CH₂)₃—, —(CH₂)₆—C(O)O—(CH₂)₄—, —(CH₂)₇—C(O)O—(CH₂)₁—, —(CH₂)₇—C(O)O—(CH₂)₂—, —(CH₂)₇—C(O)O—(CH₂)₃—, —(CH₂)₈—C(O)O—(CH₂)₁—, —(CH₂)₈—C(O)O—(CH₂)₂—, —CH₂—OC(O)—CH₂—, —CH₂—OC(O)—(CH₂)₂—, —(CH₂)₁—OC(O)—(CH₂)₃—, —(CH₂)₁—OC(O)—(CH₂)₄—, —(CH₂)₁—OC(O)—(CH₂)₅—, —(CH₂)₁—OC(O)—(CH₂)₆—, —(CH₂)₁—OC(O)—(CH₂)₇—, —(CH₂)₁—OC(O)—(CH₂)₈—, —(CH₂)₁—OC(O)—(CH₂)₉—, —(CH₂)₁—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁—, —(CH₂)₂—OC(O)—(CH₂)₂—, —(CH₂)₂—OC(O)—(CH₂)₃—, —(CH₂)₂—OC(O)—(CH₂)₄—, —(CH₂)₂—OC(O)—(CH₂)₅—, —(CH₂)₂—OC(O)—(CH₂)₆—, —(CH₂)₂—OC(O)—(CH₂)₇—, —(CH₂)₂—OC(O)—(CH₂)₈—, —(CH₂)₂—OC(O)—(CH₂)₉—, —(CH₂)₂—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁₁—, —(CH₂)₂—OC(O)—(CH₂)₁₂—, —(CH₂)₃—OC(O)—(CH₂)₁—, —(CH₂)₃—OC(O)—(CH₂)₂—, —(CH₂)₃—OC(O)—(CH₂)₃—, —(CH₂)₃—OC(O)—(CH₂)₄—, —(CH₂)₃—OC(O)—(CH₂)₅—, —(CH₂)₃—OC(O)—(CH₂)₆—, —(CH₂)₃—OC(O)—(CH₂)₇—, —(CH₂)₄—OC(O)—(CH₂)₁—, —(CH₂)₄—OC(O)—(CH₂)₂—, —(CH₂)₄—OC(O)—(CH₂)₃—, —(CH₂)₄—OC(O)—(CH₂)₄—, —(CH₂)₄—OC(O)—(CH₂)₅—, —(CH₂)₄—OC(O)—(CH₂)₆—, —(CH₂)₅—OC(O)—(CH₂)₁—, —(CH₂)₅—OC(O)—(CH₂)₂—, —(CH₂)₅—OC(O)—(CH₂)₃—, —(CH₂)₅—OC(O)—(CH₂)₄—, —(CH₂)₅—OC(O)—(CH₂)₅—, —(CH₂)₆—OC(O)—(CH₂)₁—, —(CH₂)₆—OC(O)—(CH₂)₂—, —(CH₂)₆—OC(O)—(CH₂)₃—, —(CH₂)₆—OC(O)—(CH₂)₄—, —(CH₂)₇—OC(O)—(CH₂)₁—, —(CH₂)₇—OC(O)—(CH₂)₂—, —(CH₂)₇—OC(O)—(CH₂)₃—, —(CH₂)₈—OC(O)—(CH₂)₁—, —(CH₂)₈—OC(O)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₁—, —(CH₂)₁—N(R_g11)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₃—, —(CH₂)₁—N(R_g11)—(CH₂)₄—, —(CH₂)₁—N(R_g11)—(CH₂)₅—, —(CH₂)₁—N(R_g11)—(CH₂)₆—, —(CH₂)₁—N(R_g11)—(CH₂)₇—, —(CH₂)₁—N(R_g11)—(CH₂)₈—, —(CH₂)₁—N(R_g11)—(CH₂)₉—, —(CH₂)₁—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₂—, —(CH₂)₂—N(R_g11)—(CH₂)₃—, —(CH₂)₂—N(R_g11)—(CH₂)₄—, —(CH₂)₂—N(R_g11)—(CH₂)₅—, —(CH₂)₂—N(R_g11)—(CH₂)₆—, —(CH₂)₂—N(R_g11)—(CH₂)₇—, —(CH₂)₂—N(R_g11)—(CH₂)₈—, —(CH₂)₂—N(R_g11)—(CH₂)₉—, —(CH₂)₂—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₁₂—, —(CH₂)₃—N(R_g11)—(CH₂)₁—, —(CH₂)₃—N(R_g11)—(CH₂)₂—, —(CH₂)₃—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₁—, —(CH₂)₄—N(R_g11)—(CH₂)₂—, —(CH₂)₄—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₁—, —(CH₂)₅—N(R_g11)—(CH₂)₂—, —(CH₂)₅—N(R_g11)—(CH₂)₃—, —(CH₂)₅—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₅—, —(CH₂)₆—N(R_g11)—(CH₂)₁—, —(CH₂)₆—N(R_g11)—(CH₂)₂—, —(CH₂)₆—N(R_g11)—(CH₂)₃—, —(CH₂)₇—N(R_g11)—(CH₂)₁—, —(CH₂)₇—N(R_g11)—(CH₂)₂—, —(CH₂)₇—N(R_g11)—(CH₂)₃—, —(CH₂)₈—N(R_g11)—(CH₂)₁—, —(CH₂)₈—N(R_g11)—(CH₂)₂—, —(CH₂)₈—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₁—, —CH(CH₃)—N(R_g11)—(CH₂)₂—, —CH(CH₃)—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₄—, —CH(CH₃)—N(R_g11)—(CH₂)₅—, —CH(CH₃)—N(R_g11)—(CH₂)₆—, —CH(CH₃)—N(R_g11)—(CH₂)₇—, —CH(CH₃)—N(R_g11)—(CH₂)₈—, —CH(CH₃)—N(R_g11)—(CH₂)₉—, —CH(CH₃)—N(R_g11)—(CH₂)₁₀—, —CH₂C(O)NHCH₂—, —(CH₂)₂C(O)NH(CH₂)₂—, —(CH₂)₂C(O)NH(CH₂)₃—, —(CH₂)₂C(O)NH(CH₂)₄—, —(CH₂)₂C(O)NH(CH₂)₅—, —(CH₂)₃C(O)NH(CH₂)₃—, —(CH₂)₃C(O)NH(CH₂)₄—, —(CH₂)₄C(O)NH(CH₂)₄—, —(CH₂)₅C(O)NH(CH₂)₅—, —(CH₂)₆C(O)NH(CH₂)₇—, —(CH₂)₆C(O)NH(CH₂)₆—, —(CH₂)₇C(O)NH(CH₂)₇—, —(CH₂)₈C(O)NH(CH₂)₈, —(CH₂)₉C(O)NH(CH₂)₉—, —(CH₂)₁₀C(O)NH(CH₂)₁₀—, —(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, —CH₂NHC(O)CH₂—, —(CH₂)₂NHC(O)(CH₂)₂—, —(CH₂)₂NHC(O)(CH₂)₃—, —(CH₂)₂NHC(O)(CH₂)₄—, —(CH₂)₂NHC(O)(CH₂)₅—, —(CH₂)₃NHC(O)(CH₂)₃—, —(CH₂)₃NHC(O)(CH₂)₄—, —(CH₂)₄NHC(O)(CH₂)₄—, —(CH₂)₅NHC(O)(CH₂)₅—, —(CH₂)₅NHC(O)(CH₂)₇—, —(CH₂)₆NHC(O)(CH₂)₆—, —(CH₂)₇NHC(O)(CH₂)₇—, —(CH₂)₈NHC(O)(CH₂)₈, —(CH₂)₉NHC(O)(CH₂)₉—, —(CH₂)₁₀NHC(O)(CH₂)₁₀—, —(CH₂)₄NHC(O)(CH₂)₈—, —(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, —(CH₂)₄NHC(O)CH₂—, —CH₂-piperidinylene-CH₂—, —CH₂-piperidinylene-(CH₂)₂—, —CH₂-piperidinylene-(CH₂)₃—, —CH₂-piperidinylene-(CH₂)₄—, —CH₂-piperidinylene-(CH₂)₅—, —CH₂-piperidinylene-(CH₂)₆—, —CH₂-piperidinylene-(CH₂)₇—, —CH₂-piperidinylene-(CH₂)₈—, —(CH₂)₂-piperidinylene-(CH₂)₁—, —(CH₂)₂-piperidinylene-(CH₂)₂—, —(CH₂)₂-piperidinylene-(CH₂)₃—, —(CH₂)₂-piperidinylene-(CH₂)₄—, —(CH₂)₂-piperidinylene-(CH₂)₅—, —(CH₂)₂-piperidinylene-(CH₂)₆—, —(CH₂)₂-piperidinylene-(CH₂)₇—, —(CH₂)₂-piperidinylene-(CH₂)₈—, —(CH₂)₃-piperidinylene-CH₂—, —(CH₂)₃-piperidinylene-(CH₂)₂—, —(CH₂)₃-piperidinylene-(CH₂)₃—, —(CH₂)₃-piperidinylene-(CH₂)₄—, —(CH₂)₃-piperidinylene-(CH₂)₅—, —(CH₂)₃-piperidinylene-(CH₂)₆—, —(CH₂)₃-piperidinylene-(CH₂)₇—, —(CH₂)₃-piperidinylene-(CH₂)₈—, —(CH₂)₄-piperidinylene-CH₂—, —(CH₂)₄-piperidinylene-(CH₂)₂—, —(CH₂)₄-piperidinylene-(CH₂)₃—, —(CH₂)₄-piperidinylene-(CH₂)₄—, —(CH₂)₄-piperidinylene-(CH₂)₅—, —(CH₂)₄-piperidinylene-(CH₂)₆—, —(CH₂)₄-piperidinylene-(CH₂)₇—, —(CH₂)₄-piperidinylene-(CH₂)₈—, —(CH₂)₅-piperidinylene-(CH₂)₁—, —(CH₂)₅-piperidinylene-(CH₂)₂—, —(CH₂)₅-piperidinylene-(CH₂)₃—, —(CH₂)₅-piperidinylene-(CH₂)₄—, —(CH₂)₅-piperidinylene-(CH₂)₅—, —(CH₂)₅-piperidinylene-(CH₂)₆—, —(CH₂)₅-piperidinylene-(CH₂)₇—, —(CH₂)₅-piperidinylene-(CH₂)₈—, —(CH₂)₆-piperidinylene-(CH₂)₁—, —(CH₂)₆-piperidinylene-(CH₂)₂—, —(CH₂)₆-piperidinylene-(CH₂)₃—, —(CH₂)₆-piperidinylene-(CH₂)₄—, —(CH₂)₆-piperidinylene-(CH₂)₅—, —(CH₂)₆-piperidinylene-(CH₂)₆—, —(CH₂)₆-piperidinylene-(CH₂)₇—, —(CH₂)₆-piperidinylene-(CH₂)₈—, —(CH₂)₇-piperidinylene-(CH₂)₁—, —(CH₂)₇-piperidinylene-(CH₂)₂—, —(CH₂)₇-piperidinylene-(CH₂)₃—, —(CH₂)₇-piperidinylene-(CH₂)₄—, —(CH₂)₇-piperidinylene-(CH₂)₈—, —(CH₂)₈-piperidinylene-CH₂—, —(CH₂)₈-piperidinylene-(CH₂)₂—, —(CH₂)₈-piperidinylene-(CH₂)₃—, —(CH₂)₈-piperidinylene-(CH₂)₄—, —(CH₂)₈-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-(CH₂)₆—, —(CH₂)₈-piperidinylene-(CH₂)₇—, —(CH₂)₈-piperidinylene-(CH₂)₈—, —CH₂-piperazinylene-CH₂—, —CH₂-piperazinylene-(CH₂)₂—, —CH₂-piperazinylene-(CH₂)₃—, —CH₂-piperazinylene-(CH₂)₄—, —CH₂-piperazinylene-(CH₂)₅—, —CH₂-piperazinylene-(CH₂)₆—, —CH₂-piperazinylene-(CH₂)₇—, —CH₂-piperazinylene-(CH₂)₈—, —(CH₂)₂-piperazinylene-(CH₂)₁—, —(CH₂)₂-piperazinylene-(CH₂)₂—, —(CH₂)₂-piperazinylene-(CH₂)₃—, —(CH₂)₂-piperazinylene-(CH₂)₄—, —(CH₂)₂-piperazinylene-(CH₂)₅—, —(CH₂)₂-piperazinylene-(CH₂)₆—, —(CH₂)₂-piperazinylene-(CH₂)₇—, —(CH₂)₂-piperazinylene-(CH₂)₈—, —(CH₂)₃-piperazinylene-CH₂—, —(CH₂)₃-piperazinylene-(CH₂)₂—, —(CH₂)₃-piperazinylene-(CH₂)₃—, —(CH₂)₃-piperazinylene-(CH₂)₄—, —(CH₂)₃-piperazinylene-(CH₂)₅—, —(CH₂)₃-piperazinylene-(CH₂)₆—, —(CH₂)₃-piperazinylene-(CH₂)₇—, —(CH₂)₃-piperazinylene-(CH₂)₈—, —(CH₂)₄-piperazinylene-CH₂—, —(CH₂)₄-piperazinylene-(CH₂)₂—, —(CH₂)₄-piperazinylene-(CH₂)₃—, —(CH₂)₄-piperazinylene-(CH₂)₄—, —(CH₂)₄-piperazinylene-(CH₂)₅—, —(CH₂)₄-piperazinylene-(CH₂)₆—, —(CH₂)₄-piperazinylene-(CH₂)₇—, —(CH₂)₄-piperazinylene-(CH₂)₅—, —(CH₂)₅-piperazinylene-(CH₂)₁—, —(CH₂)₅-piperazinylene-(CH₂)₂—, —(CH₂)₅-piperazinylene-(CH₂)₃—, —(CH₂)₅-piperazinylene-(CH₂)₄—, —(CH₂)₅-piperazinylene-(CH₂)₅—, —(CH₂)₅-piperazinylene-(CH₂)₆—, —(CH₂)₅-piperazinylene-(CH₂)₇—, —(CH₂)₅-piperazinylene-(CH₂)₈—, —(CH₂)₆-piperazinylene-(CH₂)₁—, —(CH₂)₆-piperazinylene-(CH₂)₂—, —(CH₂)₆-piperazinylene-(CH₂)₃—, —(CH₂)₆-piperazinylene-(CH₂)₄—, —(CH₂)₆-piperazinylene-(CH₂)₅—, —(CH₂)₆-piperazinylene-(CH₂)₆—, —(CH₂)₆-piperazinylene-(CH₂)₇—, —(CH₂)₆-piperazinylene-(CH₂)₈—, —(CH₂)₇-piperazinylene-(CH₂)₁—, —(CH₂)₇-piperazinylene-(CH₂)₂—, —(CH₂)₇-piperazinylene-(CH₂)₃—, —(CH₂)₇-piperazinylene-(CH₂)₄—, —(CH₂)₇-piperazinylene-(CH₂)₈—, —(CH₂)₈-piperazinylene-CH₂—, —(CH₂)₈-piperazinylene-(CH₂)₂—, —(CH₂)₈-piperazinylene-(CH₂)₃—, —(CH₂)₈-piperazinylene-(CH₂)₄—, —(CH₂)₈-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-(CH₂)₆—, —(CH₂)₈-piperazinylene-(CH₂)₇—, —(CH₂)₈-piperazinylene-(CH₂)₈—, —CH₂-propylene-CH₂—, —CH₂-propylene-(CH₂)₂—, —CH₂-propylene-(CH₂)₃—, —CH₂-propylene-(CH₂)₄—, —CH₂-propylene-(CH₂)₅—, —CH₂-propylene-(CH₂)₆—, —CH₂-propylene-(CH₂)₇—, —CH₂-propylene-(CH₂)₈—, —(CH₂)₂-propylene-(CH₂)₁—, —(CH₂)₂-propylene-(CH₂)₂—, —(CH₂)₂-propylene-(CH₂)₃—, —(CH₂)₂-propylene-(CH₂)₄—, —(CH₂)₂-propylene-(CH₂)₅—, —(CH₂)₂-propylene-(CH₂)₆—, —(CH₂)₂-propylene-(CH₂)₇—, —(CH₂)₂-propylene-(CH₂)₈—, —(CH₂)₃-propylene-CH₂—, —(CH₂)₃-propylene-(CH₂)₂—, —(CH₂)₃-propylene-(CH₂)₃—, —(CH₂)₃-propylene-(CH₂)₄—, —(CH₂)₃-propylene-(CH₂)₅—, —(CH₂)₃-propylene-(CH₂)₆—, —(CH₂)₃-propylene-(CH₂)₇—, —(CH₂)₃-propylene-(CH₂)₈—, —(CH₂)₄-propylene-CH₂—, —(CH₂)₄-propylene-(CH₂)₂—, —(CH₂)₄-propylene-(CH₂)₃—, —(CH₂)₄-propylene-(CH₂)₄—, —(CH₂)₄-propylene-(CH₂)₅—, —(CH₂)₄-propylene-(CH₂)₆—, —(CH₂)₄-propylene-(CH₂)₇—, —(CH₂)₄-propylene-(CH₂)₈—, —(CH₂)₅-propylene-(CH₂)₁—, —(CH₂)₅-propylene-(CH₂)₂—, —(CH₂)₅-propylene-(CH₂)₃—, —(CH₂)₅-propylene-(CH₂)₄—, —(CH₂)₅-propylene-(CH₂)₅—, —(CH₂)₅-propylene-(CH₂)₆—, —(CH₂)₅-propylene-(CH₂)₇—, —(CH₂)₅-propylene-(CH₂)₈—, —(CH₂)₆-propylene-(CH₂)₁—, —(CH₂)₆-propylene-(CH₂)₂—, —(CH₂)₆-propylene-(CH₂)₃—, —(CH₂)₆-propylene-(CH₂)₄—, —(CH₂)₆-propylene-(CH₂)₅—, —(CH₂)₆-propylene-(CH₂)₆—, —(CH₂)₆-propylene-(CH₂)₇—, —(CH₂)₆-propylene-(CH₂)₈—, —(CH₂)₇-propylene-(CH₂)₁—, —(CH₂)₇-propylene-(CH₂)₂—, —(CH₂)₇-propylene-(CH₂)₃—, —(CH₂)₇-propylene-(CH₂)₄—, —(CH₂)₇-propylene-(CH₂)₈—, —(CH₂)₈-propylene-CH₂—, —(CH₂)₈-propylene-(CH₂)₂—, —(CH₂)₈-propylene-(CH₂)₃—, —(CH₂)₈-propylene-(CH₂)₄—, —(CH₂)₈-propylene-(CH₂)₅—, —(CH₂)₈-propylene-(CH₂)₆—, —(CH₂)₈-propylene-(CH₂)₇—, —(CH₂)₈-propylene-(CH₂)₈—, —CH₂-diazacycloheptanylene-CH₂—, —CH₂-diazacycloheptanylene-(CH₂)₂—, —CH₂-diazacycloheptanylene-(CH₂)₃—, —CH₂-diazacycloheptanylene-(CH₂)₄—, —CH₂-diazacycloheptanylene-(CH₂)₅—, —CH₂-diazacycloheptanylene-(CH₂)₆—, —CH₂-diazacycloheptanylene-(CH₂)₇—, —CH₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₃-diazacycloheptanylene-CH₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₄-diazacycloheptanylene-CH₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-CH₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.2.1]octylene-CH₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.2]octylene-CH₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₈—;
  • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof; and
  • each R_g11 independently represents H or C_1-3 alkyl.

In some embodiments of the compound of Formula (I-3), L₂ represents the structure of the following formula:

In some embodiments of the compound of Formula (I-3), R_b1 represents:

• • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-3), R_b1 represents:

In some embodiments, the compound of Formula (I) is also of Formula (I-4):

• • wherein R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_b, (R_1a)_n, R_a, R_1a and n are as defined in the compound of Formula (I) above and the embodiments thereof;
  • wherein R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents N(R₃), O or S, wherein R₃ represents H or C_1-3 alkyl;
  • L₁ represents optionally substituted linear or branched C_4-60 alkylene (e.g., C₄-C₃₀ alkylene, C₄-C₂₉ alkylene, C₄-C₂₈ alkylene, C₄-C₂₇ alkylene, C₄-C₂₆ alkylene, C₄-C₂₅ alkylene, C₄-C₂₄ alkylene, C₄-C₂₃ alkylene, C₄-C₂₂ alkylene, C₄-C₂₁ alkylene, C₄-C₂₀ alkylene, C₄-C₁₉ alkylene, C₄-C₁₈ alkylene, C₄-C₁₇ alkylene, C₄-C₁₆ alkylene, C₄-C₁₅ alkylene, C₄-C₁₄ alkylene, C₄-C₁₃ alkylene, C₄-C₁₂ alkylene, C₄-C₁₁ alkylene, C₄-C₁₀ alkylene, C₄-C₉ alkylene, C₄-C₈ alkylene, C₄-C₇ alkylene, C₄-C₆ alkylene, or C₄-C₅ alkylene);
  • X₂ represents N(R₄), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, or OS(O)₂, wherein R₄ represents H or C_1-3 alkyl, or X₂ represents a bond; and
  • R_a1 represents optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 5- to 15-membered heterocyclylene);
  • and
  • R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₈ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁ alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₅ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene) optionally substituted with D or halogen, or
  • R_b represents the following formula:

R_b1—X₄-L₂-,

• • • wherein L₂ represents:
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene), or optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 5- to 15-membered heterocyclylene), optionally substituted arylene (e.g., optionally substituted C_6-10 arylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene, arylene and the heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
    • X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), 0, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted arylene (e.g., optionally substituted C_6-10 arylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 5- to 15-membered heterocyclylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, or X₄ represents a bond; and
    • R_b1 represents optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl or optionally substituted C_6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 5- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl).

In some embodiments of the compound of Formula (I-4), R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents N(R₃), O or S, wherein R₃ represents H or C_1-3 alkyl;
  • L₁ represents linear or branched C_4-60 alkylene (e.g., C₄-C₃₀ alkylene, C₄-C₂₉ alkylene, C₄-C₂₈ alkylene, C₄-C₂₇ alkylene, C₄-C₂₆ alkylene, C₄-C₂₅ alkylene, C₄-C₂₄ alkylene, C₄-C₂₃ alkylene, C₄-C₂₂ alkylene, C₄-C₂₁ alkylene, C₄-C₂₀ alkylene, C₄-C₁₉ alkylene, C₄-C₁₈ alkylene, C₄-C₁₇ alkylene, C₄-C₁₆ alkylene, C₄-C₁₅ alkylene, C₄-C₁₄ alkylene, C₄-C₁₃ alkylene, C₄-C₁₂ alkylene, C₄-C₁₁ alkylene, C₄-C₁₀ alkylene, C₄-C₉ alkylene, C₄-C₈ alkylene, C₄-C₇ alkylene, C₄-C₆ alkylene, or C₄-C₅ alkylene) which is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl (e.g., halogenated C_1-4 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), or any combination thereof;
  • X₂ represents a bond, or X₂ represents N(R₄), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, or OS(O)₂, wherein R₄ represents H or C_1-3 alkyl; and
  • R_a1 represents optionally substituted 4- to 20-membered heterocyclyl, and the 4- to 20-membered heterocyclyl is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-4 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-4 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-4 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—) (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-4), R_a1 represents:

• • azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 1,3-diazacycloheptanyl, 1,4-diazacycloheptanyl, 4,5-diazacycloheptanyl, 5- to 15-membered bridged heterocyclyl (e.g., 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, diazabicyclo[3.2.1]octyl, diazabicyclo[2.2.2]octyl, 3,8-diazabicyclo[3.2.1]octan-3-yl, and 2,5-diazabicyclo[2.2.2]octan-2-yl), or 5- to 15-memberedazaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecylene and 7-azaspiro[3.5]nonylene), with each group being independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-4), R_a1 represents:

In some embodiments of the compound of Formula (I-4), L₁ represents the structure of the following formula: ##—C_4-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_4-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-4), L₁ represents the following group: ##—(CH₂)₄—, ##—(CH₂)₅—, ##—(CH₂)₂—CF₂—(CH₂)₂—, ##—(CH₂)₆—, ##—(CH₂)₇—, ##—(CH₂)₈—, ##—(CH₂)₉—, ##—(CH₂)₁₀—, ##—(CH₂)₁₁—, ##—(CH₂)₁₂—, ##—(CH₂)₁₃—, ##—(CH₂)₁₄—, ##—(CH₂)₁₅—, ##—(CH₂)₁₆—, ##—(CH₂)₁₇—, ##—(CH₂)₁₈—, ##—(CH₂)₁₉—, ##—(CH₂)₂₀—, ##—(CH₂)₂₁—, ##—(CH₂)₂₂—, ##—(CH₂)₂₅—, or ##—(CH₂)₃₀—;

• • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-4), R_b represents C_1-60 alkyl optionally substituted with D or halogen.

In some embodiments of the compound of Formula (I-4), R_b represents the following group: CH₃, CF₃, CD₃, CH₂CH₃, —(CH₂)₂—CH₃, —(CH₂)₃—CH₃, —(CH₂)₄—CH₃, —(CH₂)₅—CH₃, —(CH₂)₆—CH₃, —(CH₂)₇—CH₃, —(CH₂)₈—CH₃, —(CH₂)₉—CH₃, —(CH₂)₁₀—CH₃, —(CH₂)₁₁—CH₃, —(CH₂)₁₂—CH₃, —(CH₂)₁₃—CH₃, —(CH₂)₁₄—CH₃, —(CH₂)₁₅—CH₃, —(CH₂)₁₆—CH₃, —(CH₂)₁₇—CH₃, —(CH₂)₁₈—CH₃, —(CH₂)₁₉—CH₃, —(CH₂)₂₀—CH₃, —(CH₂)₂₁—CH₃, —(CH₂)₂₂—CH₃, —(CH₂)₂₃—CH₃, —(CH₂)₂₄—CH₃, —(CH₂)₂₅—CH₃, —(CH₂)₂₆—CH₃, —(CH₂)₂₇—CH₃, —(CH₂)₂₈—CH₃, or —(CH₂)₂₉—CH₃.

In some embodiments of the compound of Formula (I-4), R_b represents the following formula:

R_b1—X₄-L₂-,

• • wherein L₂ represents
    • linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene)
    • optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof, or
    • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of C_3-15cycloalkylene, 4- to 15-membered heterocyclylene, C_6-10 arylene, 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene, C_6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the linear or branched C_2-60 alkylene is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof;
  • X₄ represents a bond, or X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted C_3-20cycloalkylene, optionally substituted C_6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, and the C_3-20cycloalkylene, the C_6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; and
  • R_b1 represents optionally substituted C_3-20cycloalkyl, optionally substituted C_6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C_3-20cycloalkyl, the C_6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-4), L₂ represents the structure of the following formula: —C_2-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (1-4), L₂ represents the following group:

• • —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₂—CF₂—(CH₂)₂—, —(CH₂)₆—, —(CH₂)₇—, —(CH₂)₈—, —(CH₂)₉—, —(CH₂)₁₀—, —(CH₂)₁₁—, —(CH₂)₁₂—, —(CH₂)₁₃—, —(CH₂)₁₄—, —(CH₂)₁₅—, —(CH₂)₁₆—, —(CH₂)₁₇—, —(CH₂)₁₈—, —(CH₂)₁₉—, —(CH₂)₂₀—, —(CH₂)₂₁—, —(CH₂)₂₂—, —(CH₂)₂₅—, or —(CH₂)₃₀—;
  • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the group is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (I-4), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—(R₁₂(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—(R₁₃(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₂—R₁₃—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃—R₁₂—(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each group R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R₁₄ independently represents H or C_1-3 alkyl; and each group R₁₃ is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-4), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—(O(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m1)_p1—(O(C(R^a13)(R^a14)_p2—(O(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—(N(R_g11)(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—(C(O)NH—(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—C(O)NH—(C(R^a11)(R^a12))_m2—(O(C(R^a13)(R^a14))_m3)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(NHC(O)N—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13(R^a14)_m3)_p2—(O—(C(R^a15(R^a16)_m4)_p3—;

—(C(R^a9)(R^a10))_m1—C(O)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—C(S)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—S—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—C_6-10 arylene-(C(R^a13)(R^a14))_m3—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1-(4- to 15-membered heterocyclylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1-(5- to 15-membered heteroarylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C_3-15 cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(C_3-15cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—(C_3-15cycloalkylene-(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each R_g11 independently represents H or C_1-3 alkyl;
  • the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-4), L₂ represents the structure of the following formula:

• • —CH₂—O—CH₂—, —CH₂—O—(CH₂)₂—, —(CH₂)₁—O—(CH₂)₃—, —(CH₂)₁—O—(CH₂)₄—, —(CH₂)₁—O—(CH₂)₅—, —(CH₂)₁—O—(CH₂)₆—, —(CH₂)₁—O—(CH₂)₇—, —(CH₂)₁—O—(CH₂)₈—, —(CH₂)₁—O—(CH₂)₉—, —(CH₂)₁—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁—, —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—O—(CH₂)₄—, —(CH₂)₂—O—(CH₂)₅—, —(CH₂)₂—O—(CH₂)₆—, —(CH₂)₂—O—(CH₂)₇—, —(CH₂)₂—O—(CH₂)₈—, —(CH₂)₂—O—(CH₂)₉—, —(CH₂)₂—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁₁—, —(CH₂)₂—O—(CH₂)₁₂—, —(CH₂)₃—O—(CH₂)₁—, —(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—O—(CH₂)₃—, —(CH₂)₃—O—(CH₂)₄—, —(CH₂)₃—O—(CH₂)₅—, —(CH₂)₃—O—(CH₂)₆—, —(CH₂)₃—O—(CH₂)₇—, —(CH₂)₄—O—(CH₂)₁—, —(CH₂)₄—O—(CH₂)₂—, —(CH₂)₄—O—(CH₂)₃—, —(CH₂)₄—O—(CH₂)₄—, —(CH₂)₄—O—(CH₂)₅—, —(CH₂)₄—O—(CH₂)₆—, —(CH₂)₅—O—(CH₂)₁—, —(CH₂)₅—O—(CH₂)₂—, —(CH₂)₅—O—(CH₂)₃—, —(CH₂)₅—O—(CH₂)₄—, —(CH₂)₅—O—(CH₂)₅—, —(CH₂)₆—O—(CH₂)₁—, —(CH₂)₆—O—(CH₂)₂—, —(CH₂)₆—O—(CH₂)₃—, —(CH₂)₆—O—(CH₂)₄—, —(CH₂)₇—O—(CH₂)₁—, —(CH₂)₇—O—(CH₂)₂—, —(CH₂)₇—O—(CH₂)₃—, —(CH₂)₈—O—(CH₂)₁—, —(CH₂)₈—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₁—, —CH(CH₃)—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₃—, —CH(CH₃)—O—(CH₂)₄—, —CH(CH₃)—O—(CH₂)₅—, —CH(CH₃)—O—(CH₂)₆—, —CH(CH₃)—O—(CH₂)₇—, —CH(CH₃)—O—(CH₂)₈—, —CH(CH₃)—O—(CH₂)₉—, —CH(CH₃)—O—(CH₂)₁₀—, —CH₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₂)₆—, —CH₂—(O(CH₂)₂)₇—, —CH₂—(O(CH₂)₂)₈—, —CH₂—(O(CH₂)₂)₉—, —CH₂—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₂)₁—OCH₂—, —CH₂—(O(CH₂)₂)₂—OCH₂—, —CH₂—(O(CH₂)₂)₃—OCH₂—, —CH₂—(O(CH₂)₂)₄—OCH₂—, —CH₂—(O(CH₂)₂)₅—OCH₂—, —CH₂—(O(CH₂)₂)₆—OCH₂—, —CH₂—(O(CH₂)₂)₇—OCH₂—, —CH₂—(O(CH₂)₂)₈—OCH₂—, —CH₂—(O(CH₂)₂)₉—OCH₂—, —CH₂—(O(CH₂)₂)₁₀—OCH₂—, —(CH₂)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₂)₆—, —(CH₂)₂—(O(CH₂)₂)₇—, —(CH₂)₂—(O(CH₂)₂)₈—, —(CH₂)₂—(O(CH₂)₂)₉—, —(CH₂)₂—(O(CH₂)₂)₁₀—, —(CH₂)₃—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₂)₆—, —(CH₂)₃—(O(CH₂)₂)₇—, —(CH₂)₃—(O(CH₂)₂)₈—, —(CH₂)₃—(O(CH₂)₂)₉—, —(CH₂)₃—(O(CH₂)₂)₁₀—, —(CH₂)₄—(O(CH₂)₂)₂—, —(CH₂)₄—(O(CH₂)₂)₃—, —(CH₂)₄—(O(CH₂)₂)₄—, —(CH₂)₄—(O(CH₂)₂)₅—, —(CH₂)₄—(O(CH₂)₂)₆—, —(CH₂)₄—(O(CH₂)₂)₇—, —(CH₂)₄—(O(CH₂)₂)₈—, —(CH₂)₄—(O(CH₂)₂)₉—, —(CH₂)₄—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₃)₆—, —CH₂—(O(CH₂)₃)₇—, —CH₂—(O(CH₂)₃)₈—, —CH₂—(O(CH₂)₃)₉—, —CH₂—(O(CH₂)₃)₁₀—, —(CH₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₃)₆—, —(CH₂)₂—(O(CH₂)₃)₇—, —(CH₂)₂—(O(CH₂)₃)₈—, —(CH₂)₂—(O(CH₂)₃)₉—, —(CH₂)₂—(O(CH₂)₃)₁₀—, —(CH₂)₃—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₃)₆—, —(CH₂)₃—(O(CH₂)₃)₇—, —(CH₂)₃—(O(CH₂)₃)₈—, —(CH₂)₃—(O(CH₂)₃)₉—, —(CH₂)₃—(O(CH₂)₃)₁₀—, —CH₂—O—(CH₂)₂—O—(CH₂)₃—, —CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —CH₂—O—(CH₂)₃—O—(CH₂)₂—, —CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —CH₂—O—(CH₂)₂—O—CH₂—, —(CH₂)₂—O—(CH₂)₂O—CH₂—, —(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, —CH₂—C(O)—CH₂—, —CH₂—C(O)—(CH₂)₂—, —(CH₂)₁—C(O)—(CH₂)₃—, —(CH₂)₁—C(O)—(CH₂)₄—, —(CH₂)₁—C(O)—(CH₂)₅—, —(CH₂)₁—C(O)—(CH₂)₆—, —(CH₂)₁—C(O)—(CH₂)₇—, —(CH₂)₁—C(O)—(CH₂)₈—, —(CH₂)₁—C(O)—(CH₂)₉—, —(CH₂)₁—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁—, —(CH₂)₂—C(O)—(CH₂)₂—, —(CH₂)₂—C(O)—(CH₂)₃—, —(CH₂)₂—C(O)—(CH₂)₄—, —(CH₂)₂—C(O)—(CH₂)₅—, —(CH₂)₂—C(O)—(CH₂)₆—, —(CH₂)₂—C(O)—(CH₂)₇—, —(CH₂)₂—C(O)—(CH₂)₈—, —(CH₂)₂—C(O)—(CH₂)₉—, —(CH₂)₂—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁₁—, —(CH₂)₂—C(O)—(CH₂)₁₂—, —(CH₂)₃—C(O)—(CH₂)₁—, —(CH₂)₃—C(O)—(CH₂)₂—, —(CH₂)₃—C(O)—(CH₂)₃—, —(CH₂)₃—C(O)—(CH₂)₄—, —(CH₂)₃—C(O)—(CH₂)₅—, —(CH₂)₃—C(O)—(CH₂)₆—, —(CH₂)₃—C(O)—(CH₂)₇—, —(CH₂)₄—C(O)—(CH₂)₁—, —(CH₂)₄—C(O)—(CH₂)₂—, —(CH₂)₄—C(O)—(CH₂)₃—, —(CH₂)₄—C(O)—(CH₂)₄—, —(CH₂)₄—C(O)—(CH₂)₅—, —(CH₂)₄—C(O)—(CH₂)₆—, —(CH₂)₅—C(O)—(CH₂)₁—, —(CH₂)₅—C(O)—(CH₂)₂—, —(CH₂)₅—C(O)—(CH₂)₃—, —(CH₂)₅—C(O)—(CH₂)₄—, —(CH₂)₅—C(O)—(CH₂)₅—, —(CH₂)₆—C(O)—(CH₂)₁—, —(CH₂)₆—C(O)—(CH₂)₂—, —(CH₂)₆—C(O)—(CH₂)₃—, —(CH₂)₆—C(O)—(CH₂)₄—, —(CH₂)₇—C(O)—(CH₂)₁—, —(CH₂)₇—C(O)—(CH₂)₂—, —(CH₂)₇—C(O)—(CH₂)₃—, —(CH₂)₈—C(O)—(CH₂)₁—, —(CH₂)₈—C(O)—(CH₂)₂—, —CH₂—S—CH₂—, —CH₂—S—(CH₂)₂—, —(CH₂)₁—S—(CH₂)₃—, —(CH₂)₁—S—(CH₂)₄—, —(CH₂)₁—S—(CH₂)₅—, —(CH₂)₁—S—(CH₂)₆—, —(CH₂)₁—S—(CH₂)₇—, —(CH₂)₁—S—(CH₂)₈—, —(CH₂)₁—S—(CH₂)₉—, —(CH₂)₁—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁—, —(CH₂)₂—S—(CH₂)₂—, —(CH₂)₂—S—(CH₂)₃—, —(CH₂)₂—S—(CH₂)₄—, —(CH₂)₂—S—(CH₂)₅—, —(CH₂)₂—S—(CH₂)₆—, —(CH₂)₂—S—(CH₂)₇—, —(CH₂)₂—S—(CH₂)₈—, —(CH₂)₂—S—(CH₂)₉—, —(CH₂)₂—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁₁—, —(CH₂)₂—S—(CH₂)₁₂—, —(CH₂)₃—S—(CH₂)₁—, —(CH₂)₃—S—(CH₂)₂—, —(CH₂)₃—S—(CH₂)₃—, —(CH₂)₃—S—(CH₂)₄—, —(CH₂)₃—S—(CH₂)₅—, —(CH₂)₃—S—(CH₂)₆—, —(CH₂)₃—S—(CH₂)₇—, —(CH₂)₄—S—(CH₂)₁—, —(CH₂)₄—S—(CH₂)₂—, —(CH₂)₄—S—(CH₂)₃—, —(CH₂)₄—S—(CH₂)₄—, —(CH₂)₄—S—(CH₂)₅—, —(CH₂)₄—S—(CH₂)₆—, —(CH₂)₅—S—(CH₂)₁—, —(CH₂)₅—S—(CH₂)₂—, —(CH₂)₅—S—(CH₂)₃—, —(CH₂)₅—S—(CH₂)₄—, —(CH₂)₅—S—(CH₂)₅—, —(CH₂)₆—S—(CH₂)₁—, —(CH₂)₆—S—(CH₂)₂—, —(CH₂)₆—S—(CH₂)₃—, —(CH₂)₆—S—(CH₂)₄—, —(CH₂)₇—S—(CH₂)₁—, —(CH₂)₇—S—(CH₂)₂—, —(CH₂)₇—S—(CH₂)₃—, —(CH₂)₈—S—(CH₂)₁—, —(CH₂)₈—S—(CH₂)₂—, —CH₂—C(S)—CH₂—, —CH₂—C(S)—(CH₂)₂—, —(CH₂)₁—C(S)—(CH₂)₃—, —(CH₂)₁—C(S)—(CH₂)₄—, —(CH₂)₁—C(S)—(CH₂)₅—, —(CH₂)₁—C(S)—(CH₂)₆—, —(CH₂)₁—C(S)—(CH₂)₇—, —(CH₂)₁—C(S)—(CH₂)₈—, —(CH₂)₁—C(S)—(CH₂)₉—, —(CH₂)₁—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁—, —(CH₂)₂—C(S)—(CH₂)₂—, —(CH₂)₂—C(S)—(CH₂)₃—, —(CH₂)₂—C(S)—(CH₂)₄—, —(CH₂)₂—C(S)—(CH₂)₅—, —(CH₂)₂—C(S)—(CH₂)₆—, —(CH₂)₂—C(S)—(CH₂)₇—, —(CH₂)₂—C(S)—(CH₂)₈—, —(CH₂)₂—C(S)—(CH₂)₉—, —(CH₂)₂—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁₁—, —(CH₂)₂—C(S)—(CH₂)₁₂—, —(CH₂)₃—C(S)—(CH₂)₁—, —(CH₂)₃—C(S)—(CH₂)₂—, —(CH₂)₃—C(S)—(CH₂)₃—, —(CH₂)₃—C(S)—(CH₂)₄—, —(CH₂)₃—C(S)—(CH₂)₅—, —(CH₂)₃—C(S)—(CH₂)₆—, —(CH₂)₃—C(S)—(CH₂)₇—, —(CH₂)₄—C(S)—(CH₂)₁—, —(CH₂)₄—C(S)—(CH₂)₂—, —(CH₂)₄—C(S)—(CH₂)₃—, —(CH₂)₄—C(S)—(CH₂)₄—, —(CH₂)₄—C(S)—(CH₂)₅—, —(CH₂)₄—C(S)—(CH₂)₆—, —(CH₂)₅—C(S)—(CH₂)₁—, —(CH₂)₅—C(S)—(CH₂)₂—, —(CH₂)₅—C(S)—(CH₂)₃—, —(CH₂)₅—C(S)—(CH₂)₄—, —(CH₂)₅—C(S)—(CH₂)₅—, —(CH₂)₆—C(S)—(CH₂)₁—, —(CH₂)₆—C(S)—(CH₂)₂—, —(CH₂)₆—C(S)—(CH₂)₃—, —(CH₂)₆—C(S)—(CH₂)₄—, —(CH₂)₇—C(S)—(CH₂)₁—, —(CH₂)₇—C(S)—(CH₂)₂—, —(CH₂)₇—C(S)—(CH₂)₃—, —(CH₂)₈—C(S)—(CH₂)₁—, —(CH₂)₈—C(S)—(CH₂)₂—, —CH₂—C(O)O—CH₂—, —CH₂—C(O)O—(CH₂)₂—, —(CH₂)₁—C(O)O—(CH₂)₃—, —(CH₂)₁—C(O)O—(CH₂)₄—, —(CH₂)₁—C(O)O—(CH₂)₅—, —(CH₂)₁—C(O)O—(CH₂)₆—, —(CH₂)₁—C(O)O—(CH₂)₇—, —(CH₂)₁—C(O)O—(CH₂)₈—, —(CH₂)₁—C(O)O—(CH₂)₉—, —(CH₂)₁—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁—, —(CH₂)₂—C(O)O—(CH₂)₂—, —(CH₂)₂—C(O)O—(CH₂)₃—, —(CH₂)₂—C(O)O—(CH₂)₄—, —(CH₂)₂—C(O)O—(CH₂)₅—, —(CH₂)₂—C(O)O—(CH₂)₆—, —(CH₂)₂—C(O)O—(CH₂)₇—, —(CH₂)₂—C(O)O—(CH₂)₈—, —(CH₂)₂—C(O)O—(CH₂)₉—, —(CH₂)₂—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁₁—, —(CH₂)₂—C(O)O—(CH₂)₁₂—, —(CH₂)₃—C(O)O—(CH₂)₁—, —(CH₂)₃—C(O)O—(CH₂)₂—, —(CH₂)₃—C(O)O—(CH₂)₃—, —(CH₂)₃—C(O)O—(CH₂)₄—, —(CH₂)₃—C(O)O—(CH₂)₅—, —(CH₂)₃—C(O)O—(CH₂)₆—, —(CH₂)₃—C(O)O—(CH₂)₇—, —(CH₂)₄—C(O)O—(CH₂)₁—, —(CH₂)₄—C(O)O—(CH₂)₂—, —(CH₂)₄—C(O)O—(CH₂)₃—, —(CH₂)₄—C(O)O—(CH₂)₄—, —(CH₂)₄—C(O)O—(CH₂)₅—, —(CH₂)₄—C(O)O—(CH₂)₆—, —(CH₂)₅—C(O)O—(CH₂)₁—, —(CH₂)₅—C(O)O—(CH₂)₂—, —(CH₂)₅—C(O)O—(CH₂)₃—, —(CH₂)₅—C(O)O—(CH₂)₄—, —(CH₂)₅—C(O)O—(CH₂)₅—, —(CH₂)₆—C(O)O—(CH₂)₁—, —(CH₂)₆—C(O)O—(CH₂)₂—, —(CH₂)₆—C(O)O—(CH₂)₃—, —(CH₂)₆—C(O)O—(CH₂)₄—, —(CH₂)₇—C(O)O—(CH₂)₁—, —(CH₂)₇—C(O)O—(CH₂)₂—, —(CH₂)₇—C(O)O—(CH₂)₃—, —(CH₂)₈—C(O)O—(CH₂)₁—, —(CH₂)₈—C(O)O—(CH₂)₂—, —CH₂—OC(O)—CH₂—, —CH₂—OC(O)—(CH₂)₂—, —(CH₂)₁—OC(O)—(CH₂)₃—, —(CH₂)₁—OC(O)—(CH₂)₄—, —(CH₂)₁—OC(O)—(CH₂)₅—, —(CH₂)₁—OC(O)—(CH₂)₆—, —(CH₂)₁—OC(O)—(CH₂)₇—, —(CH₂)₁—OC(O)—(CH₂)₈—, —(CH₂)₁—OC(O)—(CH₂)₉—, —(CH₂)₁—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁—, —(CH₂)₂—OC(O)—(CH₂)₂—, —(CH₂)₂—OC(O)—(CH₂)₃—, —(CH₂)₂—OC(O)—(CH₂)₄—, —(CH₂)₂—OC(O)—(CH₂)₅—, —(CH₂)₂—OC(O)—(CH₂)₆—, —(CH₂)₂—OC(O)—(CH₂)₇—, —(CH₂)₂—OC(O)—(CH₂)₈—, —(CH₂)₂—OC(O)—(CH₂)₉—, —(CH₂)₂—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁₁—, —(CH₂)₂—OC(O)—(CH₂)₁₂—, —(CH₂)₃—OC(O)—(CH₂)₁—, —(CH₂)₃—OC(O)—(CH₂)₂—, —(CH₂)₃—OC(O)—(CH₂)₃—, —(CH₂)₃—OC(O)—(CH₂)₄—, —(CH₂)₃—OC(O)—(CH₂)₅—, —(CH₂)₃—OC(O)—(CH₂)₆—, —(CH₂)₃—OC(O)—(CH₂)₇—, —(CH₂)₄—OC(O)—(CH₂)₁—, —(CH₂)₄—OC(O)—(CH₂)₂—, —(CH₂)₄—OC(O)—(CH₂)₃—, —(CH₂)₄—OC(O)—(CH₂)₄—, —(CH₂)₄—OC(O)—(CH₂)₅—, —(CH₂)₄—OC(O)—(CH₂)₆—, —(CH₂)₅—OC(O)—(CH₂)₁—, —(CH₂)₅—OC(O)—(CH₂)₂—, —(CH₂)₅—OC(O)—(CH₂)₃—, —(CH₂)₅—OC(O)—(CH₂)₄—, —(CH₂)₅—OC(O)—(CH₂)₅—, —(CH₂)₆—OC(O)—(CH₂)₁—, —(CH₂)₆—OC(O)—(CH₂)₂—, —(CH₂)₆—OC(O)—(CH₂)₃—, —(CH₂)₆—OC(O)—(CH₂)₄—, —(CH₂)₇—OC(O)—(CH₂)₁—, —(CH₂)₇—OC(O)—(CH₂)₂—, —(CH₂)₇—OC(O)—(CH₂)₃—, —(CH₂)₈—OC(O)—(CH₂)₁—, —(CH₂)₈—OC(O)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₁—, —(CH₂)₁—N(R_g11)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₃—, —(CH₂)₁—N(R_g11)—(CH₂)₄—, —(CH₂)₁—N(R_g11)—(CH₂)₅—, —(CH₂)₁—N(R_g11)—(CH₂)₆—, —(CH₂)₁—N(R_g11)—(CH₂)₇—, —(CH₂)₁—N(R_g11)—(CH₂)₈—, —(CH₂)₁—N(R_g11)—(CH₂)₉—, —(CH₂)₁—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₂—, —(CH₂)₂—N(R_g11)—(CH₂)₃—, —(CH₂)₂—N(R_g11)—(CH₂)₄—, —(CH₂)₂—N(R_g11)—(CH₂)₅—, —(CH₂)₂—N(R_g11)—(CH₂)₆—, —(CH₂)₂—N(R_g11)—(CH₂)₇—, —(CH₂)₂—N(R_g11)—(CH₂)₈—, —(CH₂)₂—N(R_g11)—(CH₂)₉—, —(CH₂)₂—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)_n—, —(CH₂)₂—N(R_g11)—(CH₂)₁₂—, —(CH₂)₃—N(R_g11)—(CH₂)₁—, —(CH₂)₃—N(R_g11)—(CH₂)₂—, —(CH₂)₃—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₁—, —(CH₂)₄—N(R_g11)—(CH₂)₂—, —(CH₂)₄—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₁—, —(CH₂)₅—N(R_g11)—(CH₂)₂—, —(CH₂)₅—N(R_g11)—(CH₂)₃—, —(CH₂)₅—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₅—, —(CH₂)₆—N(R_g11)—(CH₂)₁—, —(CH₂)₆—N(R_g11)—(CH₂)₂—, —(CH₂)₆—N(R_g11)—(CH₂)₃—, —(CH₂)₇—N(R_g11)—(CH₂)₁—, —(CH₂)₇—N(R_g11)—(CH₂)₂—, —(CH₂)₇—N(R_g11)—(CH₂)₃—, —(CH₂)₈—N(R_g11)—(CH₂)₁—, —(CH₂)₈—N(R_g11)—(CH₂)₂—, —(CH₂)₈—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₁—, —CH(CH₃)—N(R_g11)—(CH₂)₂—, —CH(CH₃)—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₄—, —CH(CH₃)—N(R_g11)—(CH₂)₅—, —CH(CH₃)—N(R_g11)—(CH₂)₆—, —CH(CH₃)—N(R_g11)—(CH₂)₇—, —CH(CH₃)—N(R_g11)—(CH₂)₈—, —CH(CH₃)—N(R_g11)—(CH₂)₉—, —CH(CH₃)—N(R_g11)—(CH₂)₁₀—, —CH₂C(O)NHCH₂—, —(CH₂)₂C(O)NH(CH₂)₂—, —(CH₂)₂C(O)NH(CH₂)₃—, —(CH₂)₂C(O)NH(CH₂)₄—, —(CH₂)₂C(O)NH(CH₂)₅—, —(CH₂)₃C(O)NH(CH₂)₃—, —(CH₂)₃C(O)NH(CH₂)₄—, —(CH₂)₄C(O)NH(CH₂)₄—, —(CH₂)₅C(O)NH(CH₂)₅—, —(CH₂)₆C(O)NH(CH₂)₇—, —(CH₂)₆C(O)NH(CH₂)₆—, —(CH₂)₇C(O)NH(CH₂)₇—, —(CH₂)₈C(O)NH(CH₂)₈, —(CH₂)₉C(O)NH(CH₂)₉—, —(CH₂)₁₀C(O)NH(CH₂)₁₀—, —(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, —CH₂NHC(O)CH₂—, —(CH₂)₂NHC(O)(CH₂)₂—, —(CH₂)₂NHC(O)(CH₂)₃—, —(CH₂)₂NHC(O)(CH₂)₄—, —(CH₂)₂NHC(O)(CH₂)₅—, —(CH₂)₃NHC(O)(CH₂)₃—, —(CH₂)₃NHC(O)(CH₂)₄—, —(CH₂)₄NHC(O)(CH₂)₄—, —(CH₂)₅NHC(O)(CH₂)₅—, —(CH₂)₆NHC(O)(CH₂)₇—, —(CH₂)₆NHC(O)(CH₂)₆—, —(CH₂)₇NHC(O)(CH₂)₇—, —(CH₂)₈NHC(O)(CH₂)₈, —(CH₂)₉NHC(O)(CH₂)₉—, —(CH₂)₁₀NHC(O)(CH₂)₁₀—, —(CH₂)₄NHC(O)(CH₂)₈—, —(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, —(CH₂)₄NHC(O)CH₂—, —CH₂-piperidinylene-CH₂—, —CH₂-piperidinylene-(CH₂)₂—, —CH₂-piperidinylene-(CH₂)₃—, —CH₂-piperidinylene-(CH₂)₄—, —CH₂-piperidinylene-(CH₂)₅—, —CH₂-piperidinylene-(CH₂)₆—, —CH₂-piperidinylene-(CH₂)₇—, —CH₂-piperidinylene-(CH₂)₈—, —(CH₂)₂-piperidinylene-(CH₂)₁—, —(CH₂)₂-piperidinylene-(CH₂)₂—, —(CH₂)₂-piperidinylene-(CH₂)₃—, —(CH₂)₂-piperidinylene-(CH₂)₄—, —(CH₂)₂-piperidinylene-(CH₂)₅—, —(CH₂)₂-piperidinylene-(CH₂)₆—, —(CH₂)₂-piperidinylene-(CH₂)₇—, —(CH₂)₂-piperidinylene-(CH₂)₈—, —(CH₂)₃-piperidinylene-CH₂—, —(CH₂)₃-piperidinylene-(CH₂)₂—, —(CH₂)₃-piperidinylene-(CH₂)₃—, —(CH₂)₃-piperidinylene-(CH₂)₄—, —(CH₂)₃-piperidinylene-(CH₂)₅—, —(CH₂)₃-piperidinylene-(CH₂)₆—, —(CH₂)₃-piperidinylene-(CH₂)₇—, —(CH₂)₃-piperidinylene-(CH₂)₈—, —(CH₂)₄-piperidinylene-CH₂—, —(CH₂)₄-piperidinylene-(CH₂)₂—, —(CH₂)₄-piperidinylene-(CH₂)₃—, —(CH₂)₄-piperidinylene-(CH₂)₄—, —(CH₂)₄-piperidinylene-(CH₂)₅—, —(CH₂)₄-piperidinylene-(CH₂)₆—, —(CH₂)₄-piperidinylene-(CH₂)₇—, —(CH₂)₄-piperidinylene-(CH₂)₈—, —(CH₂)₅-piperidinylene-(CH₂)₁—, —(CH₂)₈-piperidinylene-(CH₂)₂—, —(CH₂)₅-piperidinylene-(CH₂)₃—, —(CH₂)₅-piperidinylene-(CH₂)₄—, —(CH₂)₅-piperidinylene-(CH₂)₅—, —(CH₂)₅-piperidinylene-(CH₂)₆—, —(CH₂)₅-piperidinylene-(CH₂)₇—, —(CH₂)₅-piperidinylene-(CH₂)₈—, —(CH₂)₆-piperidinylene-(CH₂)₁—, —(CH₂)₆-piperidinylene-(CH₂)₂—, —(CH₂)₆-piperidinylene-(CH₂)₃—, —(CH₂)₆-piperidinylene-(CH₂)₄—, —(CH₂)₆-piperidinylene-(CH₂)₅—, —(CH₂)₆-piperidinylene-(CH₂)₆—, —(CH₂)₆-piperidinylene-(CH₂)₇—, —(CH₂)₆-piperidinylene-(CH₂)₈—, —(CH₂)₇-piperidinylene-(CH₂)₁—, —(CH₂)₇-piperidinylene-(CH₂)₂—, —(CH₂)₇-piperidinylene-(CH₂)₃—, —(CH₂)₇-piperidinylene-(CH₂)₄—, —(CH₂)₇-piperidinylene-(CH₂)₈—, —(CH₂)₈-piperidinylene-CH₂—, —(CH₂)₈-piperidinylene-(CH₂)₂—, —(CH₂)₈-piperidinylene-(CH₂)₃—, —(CH₂)₈-piperidinylene-(CH₂)₄—, —(CH₂)₈-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-(CH₂)₆—, —(CH₂)₈-piperidinylene-(CH₂)₇—, —(CH₂)₈-piperidinylene-(CH₂)₈—, —CH₂-piperazinylene-CH₂—, —CH₂-piperazinylene-(CH₂)₂—, —CH₂-piperazinylene-(CH₂)₃—, —CH₂-piperazinylene-(CH₂)₄—, —CH₂-piperazinylene-(CH₂)₅—, —CH₂-piperazinylene-(CH₂)₆—, —CH₂-piperazinylene-(CH₂)₇—, —CH₂-piperazinylene-(CH₂)₈—, —(CH₂)₂-piperazinylene-(CH₂)₁—, —(CH₂)₂-piperazinylene-(CH₂)₂—, —(CH₂)₂-piperazinylene-(CH₂)₃—, —(CH₂)₂-piperazinylene-(CH₂)₄—, —(CH₂)₂-piperazinylene-(CH₂)₅—, —(CH₂)₂-piperazinylene-(CH₂)₆—, —(CH₂)₂-piperazinylene-(CH₂)₇—, —(CH₂)₂-piperazinylene-(CH₂)₈—, —(CH₂)₃-piperazinylene-CH₂—, —(CH₂)₃-piperazinylene-(CH₂)₂—, —(CH₂)₃-piperazinylene-(CH₂)₃—, —(CH₂)₃-piperazinylene-(CH₂)₄—, —(CH₂)₃-piperazinylene-(CH₂)₅—, —(CH₂)₃-piperazinylene-(CH₂)₆—, —(CH₂)₃-piperazinylene-(CH₂)₇—, —(CH₂)₃-piperazinylene-(CH₂)₈—, —(CH₂)₄-piperazinylene-CH₂—, —(CH₂)₄-piperazinylene-(CH₂)₂—, —(CH₂)₄-piperazinylene-(CH₂)₃—, —(CH₂)₄-piperazinylene-(CH₂)₄—, —(CH₂)₄-piperazinylene-(CH₂)₅—, —(CH₂)₄-piperazinylene-(CH₂)₆—, —(CH₂)₄-piperazinylene-(CH₂)₇—, —(CH₂)₄-piperazinylene-(CH₂)₈—, —(CH₂)₅-piperazinylene-(CH₂)₁—, —(CH₂)₅-piperazinylene-(CH₂)₂—, —(CH₂)₅-piperazinylene-(CH₂)₃—, —(CH₂)₅-piperazinylene-(CH₂)₄—, —(CH₂)₅-piperazinylene-(CH₂)₅—, —(CH₂)₅-piperazinylene-(CH₂)₆—, —(CH₂)₅-piperazinylene-(CH₂)₇—, —(CH₂)₅-piperazinylene-(CH₂)₈—, —(CH₂)₆-piperazinylene-(CH₂)₁—, —(CH₂)₆-piperazinylene-(CH₂)₂—, —(CH₂)₆-piperazinylene-(CH₂)₃—, —(CH₂)₆-piperazinylene-(CH₂)₄—, —(CH₂)₆-piperazinylene-(CH₂)₅—, —(CH₂)₆-piperazinylene-(CH₂)₆—, —(CH₂)₆-piperazinylene-(CH₂)₇—, —(CH₂)₆-piperazinylene-(CH₂)₈—, —(CH₂)₇-piperazinylene-(CH₂)₁—, —(CH₂)₇-piperazinylene-(CH₂)₂—, —(CH₂)₇-piperazinylene-(CH₂)₃—, —(CH₂)₇-piperazinylene-(CH₂)₄—, —(CH₂)₇-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-CH₂—, —(CH₂)₈-piperazinylene-(CH₂)₂—, —(CH₂)₈-piperazinylene-(CH₂)₃—, —(CH₂)₈-piperazinylene-(CH₂)₄—, —(CH₂)₈-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-(CH₂)₆—, —(CH₂)₈-piperazinylene-(CH₂)₇—, —(CH₂)₈-piperazinylene-(CH₂)₈—, —CH₂-propylene-CH₂—, —CH₂-propylene-(CH₂)₂—, —CH₂-propylene-(CH₂)₃—, —CH₂-propylene-(CH₂)₄—, —CH₂-propylene-(CH₂)₅—, —CH₂-propylene-(CH₂)₆—, —CH₂-propylene-(CH₂)₇—, —CH₂-propylene-(CH₂)₈—, —(CH₂)₂-propylene-(CH₂)₁—, —(CH₂)₂-propylene-(CH₂)₂—, —(CH₂)₂-propylene-(CH₂)₃—, —(CH₂)₂-propylene-(CH₂)₄—, —(CH₂)₂-propylene-(CH₂)₅—, —(CH₂)₂-propylene-(CH₂)₆—, —(CH₂)₂-propylene-(CH₂)₇—, —(CH₂)₂-propylene-(CH₂)₈—, —(CH₂)₃-propylene-CH₂—, —(CH₂)₃-propylene-(CH₂)₂—, —(CH₂)₃-propylene-(CH₂)₃—, —(CH₂)₃-propylene-(CH₂)₄—, —(CH₂)₃-propylene-(CH₂)₅—, —(CH₂)₃-propylene-(CH₂)₆—, —(CH₂)₃-propylene-(CH₂)₇—, —(CH₂)₃-propylene-(CH₂)₈—, —(CH₂)₄-propylene-CH₂—, —(CH₂)₄-propylene-(CH₂)₂—, —(CH₂)₄-propylene-(CH₂)₃—, —(CH₂)₄-propylene-(CH₂)₄—, —(CH₂)₄-propylene-(CH₂)₅—, —(CH₂)₄-propylene-(CH₂)₆—, —(CH₂)₄-propylene-(CH₂)₇—, —(CH₂)₄-propylene-(CH₂)₈—, —(CH₂)₅-propylene-(CH₂)₁—, —(CH₂)₅-propylene-(CH₂)₂—, —(CH₂)₅-propylene-(CH₂)₃—, —(CH₂)₅-propylene-(CH₂)₄—, —(CH₂)₅-propylene-(CH₂)₅—, —(CH₂)₅-propylene-(CH₂)₆—, —(CH₂)₅-propylene-(CH₂)₇—, —(CH₂)₅-propylene-(CH₂)₈—, —(CH₂)₆-propylene-(CH₂)₁—, —(CH₂)₆-propylene-(CH₂)₂—, —(CH₂)₆-propylene-(CH₂)₃—, —(CH₂)₆-propylene-(CH₂)₄—, —(CH₂)₆-propylene-(CH₂)₅—, —(CH₂)₆-propylene-(CH₂)₆—, —(CH₂)₆-propylene-(CH₂)₇—, —(CH₂)₆-propylene-(CH₂)₈—, —(CH₂)₇-propylene-(CH₂)₁—, —(CH₂)₇-propylene-(CH₂)₂—, —(CH₂)₇-propylene-(CH₂)₃—, —(CH₂)₇-propylene-(CH₂)₄—, —(CH₂)₇-propylene-(CH₂)₈—, —(CH₂)₈-propylene-CH₂—, —(CH₂)₈-propylene-(CH₂)₂—, —(CH₂)₈-propylene-(CH₂)₃—, —(CH₂)₈-propylene-(CH₂)₄—, —(CH₂)₈-propylene-(CH₂)₅—, —(CH₂)₈-propylene-(CH₂)₆—, —(CH₂)₈-propylene-(CH₂)₇—, —(CH₂)₈-propylene-(CH₂)₈—, —CH₂-diazacycloheptanylene-CH₂—, —CH₂-diazacycloheptanylene-(CH₂)₂—, —CH₂-diazacycloheptanylene-(CH₂)₃—, —CH₂-diazacycloheptanylene-(CH₂)₄—, —CH₂-diazacycloheptanylene-(CH₂)₈—, —CH₂-diazacycloheptanylene-(CH₂)₆—, —CH₂-diazacycloheptanylene-(CH₂)₇—, —CH₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₃-diazacycloheptanylene-CH₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₄-diazacycloheptanylene-CH₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-CH₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.2.1]octylene-CH₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.2]octylene-CH₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₈—;
  • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof; and
  • each R_g11 independently represents H or C_1-3 alkyl.

In some embodiments of the compound of Formula (I-4), L₂ represents the structure of the following formula:

In some embodiments of the compound of Formula (I-4), R_b1 represents:

• • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-4), R_b1 represents:

In some embodiments, the compound of Formula (I) is also of Formula (I-5):

• • wherein R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_b, (R_1a)_n, R_a, R_1a and n are as defined in the compound of Formula (I) above and the embodiments thereof;
  • wherein R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents alkynylene (e.g., C₂-C₆ alkynylene) or alkenylene (e.g., C₂-C₆ alkenylene), or X₁ represents a bond;
  • L₁ represents optionally substituted linear or branched C_1-60 alkylene (e.g., C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₈ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁ alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₅ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene); X₂ represents N(R₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, or OS(O)₂, wherein R₅ represents H or C_1-3 alkyl, or X₂ represents a bond; and
  • R_a1 represents optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 5- to 15-membered heterocyclyl);
  • and
  • R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₈ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁ alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₅ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene) optionally substituted with D or halogen, or
  • R_b represents the following formula:

R_b1—X₄-L₂-,

• • • wherein L₂ represents:
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene), or
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 4- to 15-membered heterocyclylene), arylene (e.g., C_6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene, arylene and the heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
    • X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted arylene (e.g., optionally substituted C_6-20 arylene, or optionally substituted C_6-10 arylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), triazolylene-NH—, or —NH— triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, or X₄ represents a bond; and
    • R_b1 represents optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl, or optionally substituted C_6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 4- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl).

In some embodiments of the compound of Formula (I-5), R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents a bond, or X₁ represents C_2-6 alkynylene or C_2-6 alkenylene;
    • L₁ represents linear or branched C_1-60 alkylene (e.g., C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₈ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁ alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₅ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene) which is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy, or any combination thereof; and
    • X₂ represents a bond, or X₂ represents N(R₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, or OS(O)₂, wherein R₅ represents H or C_1-3 alkyl; and
    • R_a1 represents optionally substituted 4- to 20-membered heterocyclyl, and the 4- to 20-membered heterocyclyl is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂- and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-5), R_a1 represents:

• • azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 1,3-diazacycloheptanyl, 1,4-diazacycloheptanyl, 4,5-diazacycloheptanyl, 5- to 15-membered bridged heterocyclyl (e.g., 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, diazabicyclo[3.2.1]octyl, diazabicyclo[2.2.2]octyl, 3,8-diazabicyclo[3.2.1]octan-3-yl, and 2,5-diazabicyclo[2.2.2]octan-2-yl), or 5- to 15-memberedazaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecylene and 7-azaspiro[3.5]nonylene), with each group being independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-5), R_a1 represents:

In some embodiments of the compound of Formula (I-5), L₁ represents the structure of the following formula: ##—C_1-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_1-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-5), L₁ represents the following group:

• • ##—CH₂—, ##—(CH₂)₂—, ##—(CH₂)₃—, ##—(CH₂)₄—, ##—(CH₂)₅—, ##—(CH₂)₂—CF₂—(CH₂)₂—, ##—(CH₂)₆—, ##—(CH₂)₇—, ##—(CH₂)₈—, ##—(CH₂)₉—, ##—(CH₂)₁₀—, ##—(CH₂)₁₁—, ##—(CH₂)₁₂—, ##—(CH₂)₁₃—, ##—(CH₂)₁₄—, ##—(CH₂)₁₅—, ##—(CH₂)₁₆—, ##—(CH₂)₁₇—, ##—(CH₂)₁₈—, ##—(CH₂)₁₉—, ##—(CH₂)₂₀—, ##—(CH₂)₂₁—, ##—(CH₂)₂₂—, ##—(CH₂)₂₅—, or ##—(CH₂)₃₀—;
  • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-5), R_b represents C_1-60 alkyl optionally substituted with D or halogen.

In some embodiments of the compound of Formula (I-5), R_b represents the following group: CH₃, CF₃, CD₃, CH₂CH₃, —(CH₂)₂—CH₃, —(CH₂)₃—CH₃, —(CH₂)₄—CH₃, —(CH₂)₅—CH₃, —(CH₂)₆—CH₃, —(CH₂)₇—CH₃, —(CH₂)₈—CH₃, —(CH₂)₉—CH₃, —(CH₂)₁₀—CH₃, —(CH₂)₁₁—CH₃, —(CH₂)₁₂—CH₃, —(CH₂)₁₃—CH₃, —(CH₂)₁₄—CH₃, —(CH₂)₁₅—CH₃, —(CH₂)₁₆—CH₃, —(CH₂)₁₇—CH₃, —(CH₂)₁₈—CH₃, —(CH₂)₁₉—CH₃, —(CH₂)₂₀—CH₃, —(CH₂)₂₁—CH₃, —(CH₂)₂₂—CH₃, —(CH₂)₂₃—CH₃, —(CH₂)₂₄—CH₃, —(CH₂)₂₅—CH₃, —(CH₂)₂₆—CH₃, —(CH₂)₂₇—CH₃, —(CH₂)₂₈—CH₃, or —(CH₂)₂₉—CH₃.

In some embodiments of the compound of Formula (I-5), R_b represents the following formula:

R_b1—X₄-L₂-,

• • wherein L₂ represents
    • linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof, or
    • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of C_3-15cycloalkylene, 4- to 15-membered heterocyclylene, C_6-10 arylene, 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene, C_6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and the linear or branched C_2-60 alkylene is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof;
  • X₄ represents a bond, or X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted C_3-20cycloalkylene, optionally substituted C_6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, and the C_3-20cycloalkylene, the C_6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; and
  • R_b1 represents optionally substituted C_3-20cycloalkyl, optionally substituted C_6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C_3-20cycloalkyl, the C_6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl (e.g., optionally substituted cyclopropyl, optionally substituted cyclobutyl, optionally substituted cyclopentyl or optionally substituted cyclohexyl), optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-5), L₂ represents the structure of the following formula: —C_2-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (1-5), L₂ represents the following group: —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₂—CF₂—(CH₂)₂—, —(CH₂)₆—, —(CH₂)₇—, —(CH₂)₈—, —(CH₂)₉—, —(CH₂)₁₀—, —(CH₂)₁₁—, —(CH₂)₁₂—, —(CH₂)₁₃—, —(CH₂)₁₄—, —(CH₂)₁₅—, —(CH₂)₁₆—, —(CH₂)₁₇—, —(CH₂)₁₈—, —(CH₂)₁₉—, —(CH₂)₂₀—, —(CH₂)₂₁—, —(CH₂)₂₂—, —(CH₂)₂₅—, or —(CH₂)₃₀

• • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the group is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (I-5), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—(R₁₂(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—(R₁₃(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₂—R₁₃—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃—R₁₂—(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each group R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R₁₄ independently represents H or C_1-3 alkyl; and each group R₁₃ is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally substituted cyclopropyl, optionally substituted cyclobutyl, optionally substituted cyclopentyl or optionally substituted cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH—(e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-5), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1(O(C(R^a11)(R^a12))_m2)_p1;

—(C(R^a9)(R^a10))_m1(O(C(R^a11)(R^a12))_m2)_p1—(O(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—(O(C(R^a13)(R^a14))_m3)_p2—(O(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—(N(R_g11)(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—(C(O)NH—(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—C(O)NH—(C(R^a11)(R^a12))_m2—(O(C(R^a13)(R^a14))_m3)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC)—C((R^a11)(R^a12))_m2)_p1;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—(O—(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—NHC(O)—(C(R^a11)(R^a12))_m2—(O(C(R^a13)(R^a14))_m3)_p1—;

—(C(R^a9)(R^a10))_m1—NHC(O)NH—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—C(O)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—C(S)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—S—(C(R^a11)(R^a2))_m2;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—C_6-10 arylene-(C(R^a13)(R^a14))_m3—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1—(4- to 15-membered heterocyclylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1—(5- to 15-membered heteroarylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C_3-15cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(C_3-15cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—(C_3-15cycloalkylene-(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each R_g11 independently represents H or C_1-3 alkyl;
  • the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-5), L₂ represents the structure of the following formula:

• • —CH₂—O—CH₂—, —CH₂—O—(CH₂)₂—, —(CH₂)₁—O—(CH₂)₃—, —(CH₂)₁—O—(CH₂)₄—, —(CH₂)₁—O—(CH₂)₅—, —(CH₂)₁—O—(CH₂)₆—, —(CH₂)₁—O—(CH₂)₇—, —(CH₂)₁—O—(CH₂)₈—, —(CH₂)₁—O—(CH₂)₉—, —(CH₂)₁—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁—, —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—O—(CH₂)₄—, —(CH₂)₂—O—(CH₂)₅—, —(CH₂)₂—O—(CH₂)₆—, —(CH₂)₂—O—(CH₂)₇—, —(CH₂)₂—O—(CH₂)₈—, —(CH₂)₂—O—(CH₂)₉—, —(CH₂)₂—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁₁—, —(CH₂)₂—O—(CH₂)₁₂—, —(CH₂)₃—O—(CH₂)₁—, —(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—O—(CH₂)₃—, —(CH₂)₃—O—(CH₂)₄—, —(CH₂)₃—O—(CH₂)₅—, —(CH₂)₃—O—(CH₂)₆—, —(CH₂)₃—O—(CH₂)₇—, —(CH₂)₄—O—(CH₂)₁—, —(CH₂)₄—O—(CH₂)₂—, —(CH₂)₄—O—(CH₂)₃—, —(CH₂)₄—O—(CH₂)₄—, —(CH₂)₄—O—(CH₂)₅—, —(CH₂)₄—O—(CH₂)₆—, —(CH₂)₅—O—(CH₂)₁—, —(CH₂)₅—O—(CH₂)₂—, —(CH₂)₅—O—(CH₂)₃—, —(CH₂)₅—O—(CH₂)₄—, —(CH₂)₅—O—(CH₂)₅—, —(CH₂)₆—O—(CH₂)₁—, —(CH₂)₆—O—(CH₂)₂—, —(CH₂)₆—O—(CH₂)₃—, —(CH₂)₆—O—(CH₂)₄—, —(CH₂)₇—O—(CH₂)₁—, —(CH₂)₇—O—(CH₂)₂—, —(CH₂)₇—O—(CH₂)₃—, —(CH₂)₈—O—(CH₂)₁—, —(CH₂)₈—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₁—, —CH(CH₃)—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₃—, —CH(CH₃)—O—(CH₂)₄—, —CH(CH₃)—O—(CH₂)₅—, —CH(CH₃)—O—(CH₂)₆—, —CH(CH₃)—O—(CH₂)₇—, —CH(CH₃)—O—(CH₂)₈—, —CH(CH₃)—O—(CH₂)₉—, —CH(CH₃)—O—(CH₂)₁₀—, —CH₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₂)₆—, —CH₂—(O(CH₂)₂)₇—, —CH₂—(O(CH₂)₂)₈—, —CH₂—(O(CH₂)₂)₉—, —CH₂—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₂)₁—OCH₂—, —CH₂—(O(CH₂)₂)₂—OCH₂—, —CH₂—(O(CH₂)₂)₃—OCH₂—, —CH₂—(O(CH₂)₂)₄—OCH₂—, —CH₂—(O(CH₂)₂)₅—OCH₂—, —CH₂—(O(CH₂)₂)₆—OCH₂—, —CH₂—(O(CH₂)₂)₇—OCH₂—, —CH₂—(O(CH₂)₂)₈—OCH₂—, —CH₂—(O(CH₂)₂)₉—OCH₂—, —CH₂—(O(CH₂)₂)₁₀—OCH₂—, —(CH₂)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₂)₆—, —(CH₂)₂—(O(CH₂)₂)₇—, —(CH₂)₂—(O(CH₂)₂)₈—, —(CH₂)₂—(O(CH₂)₂)₉—, —(CH₂)₂—(O(CH₂)₂)₁₀—, —(CH₂)₃—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₂)₆—, —(CH₂)₃—(O(CH₂)₂)₇—, —(CH₂)₃—(O(CH₂)₂)₈—, —(CH₂)₃—(O(CH₂)₂)₉—, —(CH₂)₃—(O(CH₂)₂)₁₀—, —(CH₂)₄—(O(CH₂)₂)₂—, —(CH₂)₄—(O(CH₂)₂)₃—, —(CH₂)₄—(O(CH₂)₂)₄—, —(CH₂)₄—(O(CH₂)₂)₅—, —(CH₂)₄—(O(CH₂)₂)₆—, —(CH₂)₄—(O(CH₂)₂)₇—, —(CH₂)₄—(O(CH₂)₂)₈—, —(CH₂)₄—(O(CH₂)₂)₉—, —(CH₂)₄—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₃)₆—, —CH₂—(O(CH₂)₃)₇—, —CH₂—(O(CH₂)₃)₈—, —CH₂—(O(CH₂)₃)₉—, —CH₂—(O(CH₂)₃)₁₀—, —(CH₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₃)₆—, —(CH₂)₂—(O(CH₂)₃)₇—, —(CH₂)₂—(O(CH₂)₃)₈—, —(CH₂)₂—(O(CH₂)₃)₉—, —(CH₂)₂—(O(CH₂)₃)₁₀—, —(CH₂)₃—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₃)₆—, —(CH₂)₃—(O(CH₂)₃)₇—, —(CH₂)₃—(O(CH₂)₃)₈—, —(CH₂)₃—(O(CH₂)₃)₉—, —(CH₂)₃—(O(CH₂)₃)₁₀—, —CH₂—O—(CH₂)₂—O—(CH₂)₃—, —CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —CH₂—O—(CH₂)₃—O—(CH₂)₂—, —CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —CH₂—O—(CH₂)₂—O—CH₂—, —(CH₂)₂—O—(CH₂)₂O—CH₂—, —(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, —CH₂—C(O)—CH₂—, —CH₂—C(O)—(CH₂)₂—, —(CH₂)₁—C(O)—(CH₂)₃—, —(CH₂)₁—C(O)—(CH₂)₄—, —(CH₂)₁—C(O)—(CH₂)₅—, —(CH₂)₁—C(O)—(CH₂)₆—, —(CH₂)₁—C(O)—(CH₂)₇—, —(CH₂)₁—C(O)—(CH₂)₈—, —(CH₂)₁—C(O)—(CH₂)₉—, —(CH₂)₁—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁—, —(CH₂)₂—C(O)—(CH₂)₂—, —(CH₂)₂—C(O)—(CH₂)₃—, —(CH₂)₂—C(O)—(CH₂)₄—, —(CH₂)₂—C(O)—(CH₂)₅—, —(CH₂)₂—C(O)—(CH₂)₆—, —(CH₂)₂—C(O)—(CH₂)₇—, —(CH₂)₂—C(O)—(CH₂)₈—, —(CH₂)₂—C(O)—(CH₂)₉—, —(CH₂)₂—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁₁—, —(CH₂)₂—C(O)—(CH₂)₁₂—, —(CH₂)₃—C(O)—(CH₂)₁—, —(CH₂)₃—C(O)—(CH₂)₂—, —(CH₂)₃—C(O)—(CH₂)₃—, —(CH₂)₃—C(O)—(CH₂)₄—, —(CH₂)₃—C(O)—(CH₂)₅—, —(CH₂)₃—C(O)—(CH₂)₆—, —(CH₂)₃—C(O)—(CH₂)₇—, —(CH₂)₄—C(O)—(CH₂)₁—, —(CH₂)₄—C(O)—(CH₂)₂—, —(CH₂)₄—C(O)—(CH₂)₃—, —(CH₂)₄—C(O)—(CH₂)₄—, —(CH₂)₄—C(O)—(CH₂)₅—, —(CH₂)₄—C(O)—(CH₂)₆—, —(CH₂)₅—C(O)—(CH₂)₁—, —(CH₂)₅—C(O)—(CH₂)₂—, —(CH₂)₅—C(O)—(CH₂)₃—, —(CH₂)₅—C(O)—(CH₂)₄—, —(CH₂)₅—C(O)—(CH₂)₅—, —(CH₂)₆—C(O)—(CH₂)₁—, —(CH₂)₆—C(O)—(CH₂)₂—, —(CH₂)₆—C(O)—(CH₂)₃—, —(CH₂)₆—C(O)—(CH₂)₄—, —(CH₂)₇—C(O)—(CH₂)₁—, —(CH₂)₇—C(O)—(CH₂)₂—, —(CH₂)₇—C(O)—(CH₂)₃—, —(CH₂)₈—C(O)—(CH₂)₁—, —(CH₂)₈—C(O)—(CH₂)₂—, —CH₂—S—CH₂—, —CH₂—S—(CH₂)₂—, —(CH₂)₁—S—(CH₂)₃—, —(CH₂)₁—S—(CH₂)₄—, —(CH₂)₁—S—(CH₂)₅—, —(CH₂)₁—S—(CH₂)₆—, —(CH₂)₁—S—(CH₂)₇—, —(CH₂)₁—S—(CH₂)₈—, —(CH₂)₁—S—(CH₂)₉—, —(CH₂)₁—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁—, —(CH₂)₂—S—(CH₂)₂—, —(CH₂)₂—S—(CH₂)₃—, —(CH₂)₂—S—(CH₂)₄—, —(CH₂)₂—S—(CH₂)₅—, —(CH₂)₂—S—(CH₂)₆—, —(CH₂)₂—S—(CH₂)₇—, —(CH₂)₂—S—(CH₂)₈—, —(CH₂)₂—S—(CH₂)₉—, —(CH₂)₂—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁₁—, —(CH₂)₂—S—(CH₂)₁₂—, —(CH₂)₃—S—(CH₂)₁—, —(CH₂)₃—S—(CH₂)₂—, —(CH₂)₃—S—(CH₂)₃—, —(CH₂)₃—S—(CH₂)₄—, —(CH₂)₃—S—(CH₂)₅—, —(CH₂)₃—S—(CH₂)₆—, —(CH₂)₃—S—(CH₂)₇—, —(CH₂)₄—S—(CH₂)₁—, —(CH₂)₄—S—(CH₂)₂—, —(CH₂)₄—S—(CH₂)₃—, —(CH₂)₄—S—(CH₂)₄—, —(CH₂)₄—S—(CH₂)₅—, —(CH₂)₄—S—(CH₂)₆—, —(CH₂)₅—S—(CH₂)₁—, —(CH₂)₅—S—(CH₂)₂—, —(CH₂)₅—S—(CH₂)₃—, —(CH₂)₅—S—(CH₂)₄—, —(CH₂)₅—S—(CH₂)₅—, —(CH₂)₆—S—(CH₂)₁—, —(CH₂)₆—S—(CH₂)₂—, —(CH₂)₆—S—(CH₂)₃—, —(CH₂)₆—S—(CH₂)₄—, —(CH₂)₇—S—(CH₂)₁—, —(CH₂)₇—S—(CH₂)₂—, —(CH₂)₇—S—(CH₂)₃—, —(CH₂)₈—S—(CH₂)₁—, —(CH₂)₈—S—(CH₂)₂—, —CH₂—C(S)—CH₂—, —CH₂—C(S)—(CH₂)₂—, —(CH₂)₁—C(S)—(CH₂)₃—, —(CH₂)₁—C(S)—(CH₂)₄—, —(CH₂)₁—C(S)—(CH₂)₅—, —(CH₂)₁—C(S)—(CH₂)₆—, —(CH₂)₁—C(S)—(CH₂)₇—, —(CH₂)₁—C(S)—(CH₂)₈—, —(CH₂)₁—C(S)—(CH₂)₉—, —(CH₂)₁—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁—, —(CH₂)₂—C(S)—(CH₂)₂—, —(CH₂)₂—C(S)—(CH₂)₃—, —(CH₂)₂—C(S)—(CH₂)₄—, —(CH₂)₂—C(S)—(CH₂)₅—, —(CH₂)₂—C(S)—(CH₂)₆—, —(CH₂)₂—C(S)—(CH₂)₇—, —(CH₂)₂—C(S)—(CH₂)₈—, —(CH₂)₂—C(S)—(CH₂)₉—, —(CH₂)₂—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁₁—, —(CH₂)₂—C(S)—(CH₂)₁₂—, —(CH₂)₃—C(S)—(CH₂)₁—, —(CH₂)₃—C(S)—(CH₂)₂—, —(CH₂)₃—C(S)—(CH₂)₃—, —(CH₂)₃—C(S)—(CH₂)₄—, —(CH₂)₃—C(S)—(CH₂)₅—, —(CH₂)₃—C(S)—(CH₂)₆—, —(CH₂)₃—C(S)—(CH₂)₇—, —(CH₂)₄—C(S)—(CH₂)₁—, —(CH₂)₄—C(S)—(CH₂)₂—, —(CH₂)₄—C(S)—(CH₂)₃—, —(CH₂)₄—C(S)—(CH₂)₄—, —(CH₂)₄—C(S)—(CH₂)₅—, —(CH₂)₄—C(S)—(CH₂)₆—, —(CH₂)₅—C(S)—(CH₂)₁—, —(CH₂)₅—C(S)—(CH₂)₂—, —(CH₂)₅—C(S)—(CH₂)₃—, —(CH₂)₅—C(S)—(CH₂)₄—, —(CH₂)₅—C(S)—(CH₂)₅—, —(CH₂)₆—C(S)—(CH₂)₁—, —(CH₂)₆—C(S)—(CH₂)₂—, —(CH₂)₆—C(S)—(CH₂)₃—, —(CH₂)₆—C(S)—(CH₂)₄—, —(CH₂)₇—C(S)—(CH₂)₁—, —(CH₂)₇—C(S)—(CH₂)₂—, —(CH₂)₇—C(S)—(CH₂)₃—, —(CH₂)₈—C(S)—(CH₂)₁—, —(CH₂)₈—C(S)—(CH₂)₂—, —CH₂—C(O)O—CH₂—, —CH₂—C(O)O—(CH₂)₂—, —(CH₂)₁—C(O)O—(CH₂)₃—, —(CH₂)₁—C(O)O—(CH₂)₄—, —(CH₂)₁—C(O)O—(CH₂)₅—, —(CH₂)₁—C(O)O—(CH₂)₆—, —(CH₂)₁—C(O)O—(CH₂)₇—, —(CH₂)₁—C(O)O—(CH₂)₈—, —(CH₂)₁—C(O)O—(CH₂)₉—, —(CH₂)₁—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁—, —(CH₂)₂—C(O)O—(CH₂)₂—, —(CH₂)₂—C(O)O—(CH₂)₃—, —(CH₂)₂—C(O)O—(CH₂)₄—, —(CH₂)₂—C(O)O—(CH₂)₅—, —(CH₂)₂—C(O)O—(CH₂)₆—, —(CH₂)₂—C(O)O—(CH₂)₇—, —(CH₂)₂—C(O)O—(CH₂)₈—, —(CH₂)₂—C(O)O—(CH₂)₉—, —(CH₂)₂—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁₁—, —(CH₂)₂—C(O)O—(CH₂)₁₂—, —(CH₂)₃—C(O)O—(CH₂)₁—, —(CH₂)₃—C(O)O—(CH₂)₂—, —(CH₂)₃—C(O)O—(CH₂)₃—, —(CH₂)₃—C(O)O—(CH₂)₄—, —(CH₂)₃—C(O)O—(CH₂)₅—, —(CH₂)₃—C(O)O—(CH₂)₆—, —(CH₂)₃—C(O)O—(CH₂)₇—, —(CH₂)₄—C(O)O—(CH₂)₁—, —(CH₂)₄—C(O)O—(CH₂)₂—, —(CH₂)₄—C(O)O—(CH₂)₃—, —(CH₂)₄—C(O)O—(CH₂)₄—, —(CH₂)₄—C(O)O—(CH₂)₅—, —(CH₂)₄—C(O)O—(CH₂)₆—, —(CH₂)₅—C(O)O—(CH₂)₁—, —(CH₂)₅—C(O)O—(CH₂)₂—, —(CH₂)₅—C(O)O—(CH₂)₃—, —(CH₂)₅—C(O)O—(CH₂)₄—, —(CH₂)₅—C(O)O—(CH₂)₅—, —(CH₂)₆—C(O)O—(CH₂)₁—, —(CH₂)₆—C(O)O—(CH₂)₂—, —(CH₂)₆—C(O)O—(CH₂)₃—, —(CH₂)₆—C(O)O—(CH₂)₄—, —(CH₂)₇—C(O)O—(CH₂)₁—, —(CH₂)₇—C(O)O—(CH₂)₂—, —(CH₂)₇—C(O)O—(CH₂)₃—, —(CH₂)₈—C(O)O—(CH₂)₁—, —(CH₂)₈—C(O)O—(CH₂)₂—, —CH₂—OC(O)—CH₂—, —CH₂—OC(O)—(CH₂)₂—, —(CH₂)₁—OC(O)—(CH₂)₃—, —(CH₂)₁—OC(O)—(CH₂)₄—, —(CH₂)₁—OC(O)—(CH₂)₅—, —(CH₂)₁—OC(O)—(CH₂)₆—, —(CH₂)₁—OC(O)—(CH₂)₇—, —(CH₂)₁—OC(O)—(CH₂)₈—, —(CH₂)₁—OC(O)—(CH₂)₉—, —(CH₂)₁—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁—, —(CH₂)₂—OC(O)—(CH₂)₂—, —(CH₂)₂—OC(O)—(CH₂)₃—, —(CH₂)₂—OC(O)—(CH₂)₄—, —(CH₂)₂—OC(O)—(CH₂)₅—, —(CH₂)₂—OC(O)—(CH₂)₆—, —(CH₂)₂—OC(O)—(CH₂)₇—, —(CH₂)₂—OC(O)—(CH₂)₈—, —(CH₂)₂—OC(O)—(CH₂)₉—, —(CH₂)₂—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁₁—, —(CH₂)₂—OC(O)—(CH₂)₁₂—, —(CH₂)₃—OC(O)—(CH₂)₁—, —(CH₂)₃—OC(O)—(CH₂)₂—, —(CH₂)₃—OC(O)—(CH₂)₃—, —(CH₂)₃—OC(O)—(CH₂)₄—, —(CH₂)₃—OC(O)—(CH₂)₅—, —(CH₂)₃—OC(O)—(CH₂)₆—, —(CH₂)₃—OC(O)—(CH₂)₇—, —(CH₂)₄—OC(O)—(CH₂)₁—, —(CH₂)₄—OC(O)—(CH₂)₂—, —(CH₂)₄—OC(O)—(CH₂)₃—, —(CH₂)₄—OC(O)—(CH₂)₄—, —(CH₂)₄—OC(O)—(CH₂)₅—, —(CH₂)₄—OC(O)—(CH₂)₆—, —(CH₂)₅—OC(O)—(CH₂)₁—, —(CH₂)₅—OC(O)—(CH₂)₂—, —(CH₂)₅—OC(O)—(CH₂)₃—, —(CH₂)₅—OC(O)—(CH₂)₄—, —(CH₂)₅—OC(O)—(CH₂)₅—, —(CH₂)₆—OC(O)—(CH₂)₁—, —(CH₂)₆—OC(O)—(CH₂)₂—, —(CH₂)₆—OC(O)—(CH₂)₃—, —(CH₂)₆—OC(O)—(CH₂)₄—, —(CH₂)₇—OC(O)—(CH₂)₁—, —(CH₂)₇—OC(O)—(CH₂)₂—, —(CH₂)₇—OC(O)—(CH₂)₃—, —(CH₂)₈—OC(O)—(CH₂)₁—, —(CH₂)₈—OC(O)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₁—, —(CH₂)₁—N(R_g11)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₃—, —(CH₂)₁—N(R_g11)—(CH₂)₄—, —(CH₂)₁—N(R_g11)—(CH₂)₅—, —(CH₂)₁—N(R_g11)—(CH₂)₆—, —(CH₂)₁—N(R_g11)—(CH₂)₇—, —(CH₂)₁—N(R_g11)—(CH₂)₈—, —(CH₂)₁—N(R_g11)—(CH₂)₉—, —(CH₂)₁—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₂—, —(CH₂)₂—N(R_g11)—(CH₂)₃—, —(CH₂)₂—N(R_g11)—(CH₂)₄—, —(CH₂)₂—N(R_g11)—(CH₂)₅—, —(CH₂)₂—N(R_g11)—(CH₂)₆—, —(CH₂)₂—N(R_g11)—(CH₂)₇—, —(CH₂)₂—N(R_g11)—(CH₂)₈—, —(CH₂)₂—N(R_g11)—(CH₂)₉—, —(CH₂)₂—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₁₂—, —(CH₂)₃—N(R_g11)—(CH₂)₁—, —(CH₂)₃—N(R_g11)—(CH₂)₂—, —(CH₂)₃—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₁—, —(CH₂)₄—N(R_g11)—(CH₂)₂—, —(CH₂)₄—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₁—, —(CH₂)₅—N(R_g11)—(CH₂)₂—, —(CH₂)₅—N(R_g11)—(CH₂)₃—, —(CH₂)₅—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₅—, —(CH₂)₆—N(R_g11)—(CH₂)₁—, —(CH₂)₆—N(R_g11)—(CH₂)₂—, —(CH₂)₆—N(R_g11)—(CH₂)₃—, —(CH₂)₇—N(R_g11)—(CH₂)₁—, —(CH₂)₇—N(R_g11)—(CH₂)₂—, —(CH₂)₇—N(R_g11)—(CH₂)₃—, —(CH₂)₈—N(R_g11)—(CH₂)₁—, —(CH₂)₅—N(R_g11)—(CH₂)₂—, —(CH₂)₈—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₁—, —CH(CH₃)—N(R_g11)—(CH₂)₂—, —CH(CH₃)—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₄—, —CH(CH₃)—N(R_g11)—(CH₂)₅—, —CH(CH₃)—N(R_g11)—(CH₂)₆—, —CH(CH₃)—N(R_g11)—(CH₂)₇—, —CH(CH₃)—N(R_g11)—(CH₂)₈—, —CH(CH₃)—N(R_g11)—(CH₂)₉—, —CH(CH₃)—N(R_g11)—(CH₂)₁₀—, —CH₂C(O)NHCH₂—, —(CH₂)₂C(O)NH(CH₂)₂—, —(CH₂)₂C(O)NH(CH₂)₃—, —(CH₂)₂C(O)NH(CH₂)₄—, —(CH₂)₂C(O)NH(CH₂)₅—, —(CH₂)₃C(O)NH(CH₂)₃—, —(CH₂)₃C(O)NH(CH₂)₄—, —(CH₂)₄C(O)NH(CH₂)₄—, —(CH₂)₅C(O)NH(CH₂)₅—, —(CH₂)₆C(O)NH(CH₂)₇—, —(CH₂)₆C(O)NH(CH₂)₆—, —(CH₂)₇C(O)NH(CH₂)₇—, —(CH₂)₈C(O)NH(CH₂)₈, —(CH₂)₉C(O)NH(CH₂)₉—, —(CH₂)₁₀C(O)NH(CH₂)₁₀—, —(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, —CH₂NHC(O)CH₂—, —(CH₂)₂NHC(O)(CH₂)₂—, —(CH₂)₂NHC(O)(CH₂)₃—, —(CH₂)₂NHC(O)(CH₂)₄—, —(CH₂)₂NHC(O)(CH₂)₅—, —(CH₂)₃NHC(O)(CH₂)₃—, —(CH₂)₃NHC(O)(CH₂)₄—, —(CH₂)₄NHC(O)(CH₂)₄—, —(CH₂)₅NHC(O)(CH₂)₅—, —(CH₂)₆NHC(O)(CH₂)₇—, —(CH₂)₆NHC(O)(CH₂)₆—, —(CH₂)₇NHC(O)(CH₂)₇—, —(CH₂)₈NHC(O)(CH₂)₈, —(CH₂)₉NHC(O)(CH₂)₉—, —(CH₂)₁₀NHC(O)(CH₂)₁₀—, —(CH₂)₄NHC(O)(CH₂)₅—, —(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, —(CH₂)₄NHC(O)CH₂—, —CH₂-piperidinylene-CH₂—, —CH₂-piperidinylene-(CH₂)₂—, —CH₂-piperidinylene-(CH₂)₃—, —CH₂-piperidinylene-(CH₂)₄—, —CH₂-piperidinylene-(CH₂)₅—, —CH₂-piperidinylene-(CH₂)₆—, —CH₂-piperidinylene-(CH₂)₇—, —CH₂-piperidinylene-(CH₂)₈—, —(CH₂)₂-piperidinylene-(CH₂)₁—, —(CH₂)₂-piperidinylene-(CH₂)₂—, —(CH₂)₂-piperidinylene-(CH₂)₃—, —(CH₂)₂-piperidinylene-(CH₂)₄—, —(CH₂)₂-piperidinylene-(CH₂)₅—, —(CH₂)₂-piperidinylene-(CH₂)₆—, —(CH₂)₂-piperidinylene-(CH₂)₇—, —(CH₂)₂-piperidinylene-(CH₂)₈—, —(CH₂)₃-piperidinylene-CH₂—, —(CH₂)₃-piperidinylene-(CH₂)₂—, —(CH₂)₃-piperidinylene-(CH₂)₃—, —(CH₂)₃-piperidinylene-(CH₂)₄—, —(CH₂)₃-piperidinylene-(CH₂)₅—, —(CH₂)₃-piperidinylene-(CH₂)₆—, —(CH₂)₃-piperidinylene-(CH₂)₇—, —(CH₂)₃-piperidinylene-(CH₂)₈—, —(CH₂)₄-piperidinylene-CH₂—, —(CH₂)₄-piperidinylene-(CH₂)₂—, —(CH₂)₄-piperidinylene-(CH₂)₃—, —(CH₂)₄-piperidinylene-(CH₂)₄—, —(CH₂)₄-piperidinylene-(CH₂)₅—, —(CH₂)₄-piperidinylene-(CH₂)₆—, —(CH₂)₄-piperidinylene-(CH₂)₇—, —(CH₂)₄-piperidinylene-(CH₂)₈—, —(CH₂)₅-piperidinylene-(CH₂)₁—, —(CH₂)₈-piperidinylene-(CH₂)₂—, —(CH₂)₅-piperidinylene-(CH₂)₃—, —(CH₂)₅-piperidinylene-(CH₂)₄—, —(CH₂)₅-piperidinylene-(CH₂)₅—, —(CH₂)₅-piperidinylene-(CH₂)₆—, —(CH₂)₅-piperidinylene-(CH₂)₇—, —(CH₂)₅-piperidinylene-(CH₂)₈—, —(CH₂)₆-piperidinylene-(CH₂)₁—, —(CH₂)₆-piperidinylene-(CH₂)₂—, —(CH₂)₆-piperidinylene-(CH₂)₃—, —(CH₂)₆-piperidinylene-(CH₂)₄—, —(CH₂)₆-piperidinylene-(CH₂)₅—, —(CH₂)₆-piperidinylene-(CH₂)₆—, —(CH₂)₆-piperidinylene-(CH₂)₇—, —(CH₂)₆-piperidinylene-(CH₂)₈—, —(CH₂)₇-piperidinylene-(CH₂)₁—, —(CH₂)₇-piperidinylene-(CH₂)₂—, —(CH₂)₇-piperidinylene-(CH₂)₃—, —(CH₂)₇-piperidinylene-(CH₂)₄—, —(CH₂)₇-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-CH₂—, —(CH₂)₈-piperidinylene-(CH₂)₂—, —(CH₂)₈-piperidinylene-(CH₂)₃—, —(CH₂)₈-piperidinylene-(CH₂)₄—, —(CH₂)₈-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-(CH₂)₆—, —(CH₂)₈-piperidinylene-(CH₂)₇—, —(CH₂)₈-piperidinylene-(CH₂)₈—, —CH₂-piperazinylene-CH₂—, —CH₂-piperazinylene-(CH₂)₂—, —CH₂-piperazinylene-(CH₂)₃—, —CH₂-piperazinylene-(CH₂)₄—, —CH₂-piperazinylene-(CH₂)₅—, —CH₂-piperazinylene-(CH₂)₆—, —CH₂-piperazinylene-(CH₂)₇—, —CH₂-piperazinylene-(CH₂)₈—, —(CH₂)₂-piperazinylene-(CH₂)₁—, —(CH₂)₂-piperazinylene-(CH₂)₂—, —(CH₂)₂-piperazinylene-(CH₂)₃—, —(CH₂)₂-piperazinylene-(CH₂)₄—, —(CH₂)₂-piperazinylene-(CH₂)₅—, —(CH₂)₂-piperazinylene-(CH₂)₆—, —(CH₂)₂-piperazinylene-(CH₂)₇—, —(CH₂)₂-piperazinylene-(CH₂)₈—, —(CH₂)₃-piperazinylene-CH₂—, —(CH₂)₃-piperazinylene-(CH₂)₂—, —(CH₂)₃-piperazinylene-(CH₂)₃—, —(CH₂)₃-piperazinylene-(CH₂)₄—, —(CH₂)₃-piperazinylene-(CH₂)₅—, —(CH₂)₃-piperazinylene-(CH₂)₆—, —(CH₂)₃-piperazinylene-(CH₂)₇—, —(CH₂)₃-piperazinylene-(CH₂)₈—, —(CH₂)₄-piperazinylene-CH₂—, —(CH₂)₄-piperazinylene-(CH₂)₂—, —(CH₂)₄-piperazinylene-(CH₂)₃—, —(CH₂)₄-piperazinylene-(CH₂)₄—, —(CH₂)₄-piperazinylene-(CH₂)₅—, —(CH₂)₄-piperazinylene-(CH₂)₆—, —(CH₂)₄-piperazinylene-(CH₂)₇—, —(CH₂)₄-piperazinylene-(CH₂)₈—, —(CH₂)₅-piperazinylene-(CH₂)₁—, —(CH₂)₅-piperazinylene-(CH₂)₂—, —(CH₂)₅-piperazinylene-(CH₂)₃—, —(CH₂)₅-piperazinylene-(CH₂)₄—, —(CH₂)₅-piperazinylene-(CH₂)₅—, —(CH₂)₅-piperazinylene-(CH₂)₆—, —(CH₂)₈-piperazinylene-(CH₂)₇—, —(CH₂)₅-piperazinylene-(CH₂)₈—, —(CH₂)₆-piperazinylene-(CH₂)₁—, —(CH₂)₆-piperazinylene-(CH₂)₂—, —(CH₂)₆-piperazinylene-(CH₂)₃—, —(CH₂)₆-piperazinylene-(CH₂)₄—, —(CH₂)₆-piperazinylene-(CH₂)₅—, —(CH₂)₆-piperazinylene-(CH₂)₆—, —(CH₂)₆-piperazinylene-(CH₂)₇—, —(CH₂)₆-piperazinylene-(CH₂)₈—, —(CH₂)₇-piperazinylene-(CH₂)₁—, —(CH₂)₇-piperazinylene-(CH₂)₂—, —(CH₂)₇-piperazinylene-(CH₂)₃—, —(CH₂)₇-piperazinylene-(CH₂)₄—, —(CH₂)₇-piperazinylene-(CH₂)₈—, —(CH₂)₈-piperazinylene-CH₂—, —(CH₂)₈-piperazinylene-(CH₂)₂—, —(CH₂)₈-piperazinylene-(CH₂)₃—, —(CH₂)₈-piperazinylene-(CH₂)₄—, —(CH₂)₈-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-(CH₂)₆—, —(CH₂)₈-piperazinylene-(CH₂)₇—, —(CH₂)₈-piperazinylene-(CH₂)₈—, —CH₂-propylene-CH₂—, —CH₂-propylene-(CH₂)₂—, —CH₂-propylene-(CH₂)₃—, —CH₂-propylene-(CH₂)₄—, —CH₂-propylene-(CH₂)₅—, —CH₂-propylene-(CH₂)₆—, —CH₂-propylene-(CH₂)₇—, —CH₂-propylene-(CH₂)₈—, —(CH₂)₂-propylene-(CH₂)₁—, —(CH₂)₂-propylene-(CH₂)₂—, —(CH₂)₂-propylene-(CH₂)₃—, —(CH₂)₂-propylene-(CH₂)₄—, —(CH₂)₂-propylene-(CH₂)₅—, —(CH₂)₂-propylene-(CH₂)₆—, —(CH₂)₂-propylene-(CH₂)₇—, —(CH₂)₂-propylene-(CH₂)₈—, —(CH₂)₃-propylene-CH₂—, —(CH₂)₃-propylene-(CH₂)₂—, —(CH₂)₃-propylene-(CH₂)₃—, —(CH₂)₃-propylene-(CH₂)₄—, —(CH₂)₃-propylene-(CH₂)₅—, —(CH₂)₃-propylene-(CH₂)₆—, —(CH₂)₃-propylene-(CH₂)₇—, —(CH₂)₃-propylene-(CH₂)₈—, —(CH₂)₄-propylene-CH₂—, —(CH₂)₄-propylene-(CH₂)₂—, —(CH₂)₄-propylene-(CH₂)₃—, —(CH₂)₄-propylene-(CH₂)₄—, —(CH₂)₄-propylene-(CH₂)₅—, —(CH₂)₄-propylene-(CH₂)₆—, —(CH₂)₄-propylene-(CH₂)₇—, —(CH₂)₄-propylene-(CH₂)₈—, —(CH₂)₅-propylene-(CH₂)₁—, —(CH₂)₅-propylene-(CH₂)₂—, —(CH₂)₅-propylene-(CH₂)₃—, —(CH₂)₅-propylene-(CH₂)₄—, —(CH₂)₅-propylene-(CH₂)₅—, —(CH₂)₅-propylene-(CH₂)₆—, —(CH₂)₅-propylene-(CH₂)₇—, —(CH₂)₅-propylene-(CH₂)₈—, —(CH₂)₆-propylene-(CH₂)₁—, —(CH₂)₆-propylene-(CH₂)₂—, —(CH₂)₆-propylene-(CH₂)₃—, —(CH₂)₆-propylene-(CH₂)₄—, —(CH₂)₆-propylene-(CH₂)₅—, —(CH₂)₆-propylene-(CH₂)₆—, —(CH₂)₆-propylene-(CH₂)₇—, —(CH₂)₆-propylene-(CH₂)₈—, —(CH₂)₇-propylene-(CH₂)₁—, —(CH₂)₇-propylene-(CH₂)₂—, —(CH₂)₇-propylene-(CH₂)₃—, —(CH₂)₇-propylene-(CH₂)₄—, —(CH₂)₇-propylene-(CH₂)₈—, —(CH₂)₈-propylene-CH₂—, —(CH₂)₈-propylene-(CH₂)₂—, —(CH₂)₈-propylene-(CH₂)₃—, —(CH₂)₈-propylene-(CH₂)₄—, —(CH₂)₈-propylene-(CH₂)₅—, —(CH₂)₈-propylene-(CH₂)₆—, —(CH₂)₈-propylene-(CH₂)₇—, —(CH₂)₈-propylene-(CH₂)₈—, —CH₂-diazacycloheptanylene-CH₂—, —CH₂-diazacycloheptanylene-(CH₂)₂—, —CH₂-diazacycloheptanylene-(CH₂)₃—, —CH₂-diazacycloheptanylene-(CH₂)₄—, —CH₂-diazacycloheptanylene-(CH₂)₅—, —CH₂-diazacycloheptanylene-(CH₂)₆—, —CH₂-diazacycloheptanylene-(CH₂)₇—, —CH₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₃-diazacycloheptanylene-CH₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₄-diazacycloheptanylene-CH₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-CH₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.2.1]octylene-CH₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.2]octylene-CH₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₈—;
  • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof; and
  • each R_g11 independently represents H or C_1-3 alkyl.

In some embodiments of the compound of Formula (I-5), L₂ represents the structure of the following formula:

In some embodiments of the compound of Formula (I-5), R_b1 represents:

• • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-5), R_b1 represents:

In some embodiments, the compound of Formula (I) is also Formula (I-6):

• • wherein R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_e, (R_1a)_n, R_a, R_1a and n are as defined in the compound of Formula (I) above and the embodiments thereof;
  • wherein R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents N(R₆), O, S, alkynylene (e.g., C_2-6 alkynylene), or alkenylene (e.g., C_2-6 alkenylene), wherein R₆ represents H or C_1-3 alkyl, or X₁ represents a bond;
  • L₁ represents optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₇ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₈ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₇ and R₈ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₇, R₈ or a combination of R₇ and R₈; wherein each R₇ is independently selected from the group consisting of O, S, N(R₉), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₉ represents H or C_1-3 alkyl, and in case that two or more groups R₇ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₇ are not directly connected to each other; and wherein each R₈ is independently selected from the group consisting of (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 5- to 15-membered heterocyclylene), triazolylene, alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene and the triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
  • X₂ represents N(R₁₀), C(O)O, OC(O), C(O)NH, NHC(O), C(O), 0, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH—, —NH-triazolylene, or optionally substituted phenylene, wherein R₁₀ represents H or C_1-3 alkyl, or X₂ represents a bond; and
  • R_a1 represents hydroxy, optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 5- to 15-membered heterocyclyl) or optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), wherein when R_a1 represents hydroxy, X₂ represents a bond;
  • and
  • R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkyl, C₁-C₂₉ alkyl, C₁-C₂₈ alkyl, C₁-C₂₇ alkyl, C₁-C₂₆ alkyl, C₁-C₂₅ alkyl, C₁-C₂₄ alkyl, C₁-C₂₃ alkyl, C₁-C₂₂ alkyl, C₁-C₂₁ alkyl, C₁-C₂₀ alkyl, C₁-C₁₉ alkyl, C₁-C₁₈ alkyl, C₁-C₁₇ alkyl, C₁-C₁₆ alkyl, C₁-C₁₅ alkyl, C₁-C₁₄ alkyl, C₁-C₁₃ alkyl, C₁-C₁₂ alkyl, C₁-C₁₁ alkyl, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₅ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, or C₁-C₂ alkyl) optionally substituted with D or halogen, or
  • R_b represents the following formula:

R_b1—X₄-L₂-,

• • • wherein L₂ represents:
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₅ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene), or
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂—C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₅ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃ or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15cycloalkylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 4- to 15-membered heterocyclylene), arylene (e.g., C_6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene, arylene and the heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
    • X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), 0, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted arylene (e.g., optionally substituted C_6-20 arylene, or optionally substituted C_6-10 arylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), triazolylene-NH—, or —NH— triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, or X₄ represents a bond; and
    • R_b1 represents optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl, or optionally substituted C_6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 4- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl).

In some embodiments of the compound of Formula (I-6), R_a represents the following formula:

R_a1—X₂-L₁-X₁—,

• • wherein X₁ represents a bond, or X₁ represents N(R₆), O, S, C_2-6 alkynylene, or C_2-6 alkenylene, wherein R₆ represents H or C_1-3 alkyl;
  • L₁ represents optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₇ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₈ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₇ and R₈ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₇, R₈ or a combination of R₇ and R₈; wherein each R₇ is independently selected from the group consisting of O, S, N(R₉), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₉ represents H or C_1-3 alkyl, and in case that two or more groups R₇ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₇ are not directly connected to each other; and wherein each R₈ is independently selected from the group consisting of C_3-15cycloalkylene, 4- to 15-membered heterocyclylene, triazolylene or any combination thereof, wherein the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene and the triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the linear or branched C_2-60 alkylene is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C_1-6 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂- or CH₂ClCH₂—), optionally deuterated C_3-6cycloalkyl, C_1-6 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), or any combination thereof;
  • X₂ represents a bond, or X₂ represents N(R₁₀), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH—, —NH— triazolylene, or optionally substituted phenylene, wherein R₁₀ represents H or C_1-3 alkyl, and the 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms is optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), oxo, hydroxy, amino, mercapto, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; and the phenylene is optionally substituted with 1 to 4 substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; and
  • R_a1 represents hydroxy, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted C_3-20cycloalkyl, wherein when R_a1 represents hydroxy, X₂ represents a bond, and the 4- to 20-membered heterocyclyl and the C_3-20cycloalkyl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-6), R_a1 represents hydroxy, and X₂ represents a bond.

In some embodiments of the compound of Formula (I-6), R_a1 represents:

• • azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 1,3-diazacycloheptanyl, 1,4-diazacycloheptanyl, 4,5-diazacycloheptanyl, 5- to 15-membered bridged heterocyclyl (e.g., 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, diazabicyclo[3.2.1]octyl, diazabicyclo[2.2.2]octyl, 3,8-diazabicyclo[3.2.1]octan-3-yl, and 2,5-diazabicyclo[2.2.2]octan-2-yl), or 5- to 15-memberedazaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecylene and 7-azaspiro[3.5]nonylene), with each group being independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of: D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-6), R_a1 represents:

In some embodiments of the compound of Formula (I-6), L₁ represents the structure of the following formula:

##—(C(R^a1)(R^a2))_m1—(R₇(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R₇(C(R^a3)(R^a4))_m2)_p1—(R₇(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R₇(C(R^a3)(R^a4))_m2)_p1—(R₇(C(R^a5)(R^a6))_m3)_p2—(R₇(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(R₈(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R₈(C(R^a3)(R^a4))_m2)_p1—(R₈(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R₈(C(R^a3)(R^a4))_m2)_p1—(R₈(C(R^a5)(R^a6))_m3)_p2—(R₈(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(R₇—R₈—(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(R₇(C(R^a3)(R^a4))_m2)_p1—(R₈(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(R₈—R₇—(C(R^a3)(R^a4))_m2)_p1—; or

##—(C(R^a1)(R^a2))_m1—(R₈(C(R^a3)(R^a4))_m2)_p1—(R₇(C(R^a5)(R^a6))_m3)_p2—;

• • wherein each group R₇ is independently selected from the group consisting of O, S, N(R₉), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R₉ independently represents H or C_1-3 alkyl; and each group R₈ is independently selected from the group consisting of C_3-15cycloalkylene, 4- to 15-membered heterocyclylene, triazolylene or any combination thereof, wherein the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene and the triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • R^a1, R^a2, R^a3, R^a4, R^a5, R^a6, R^a7 and R^a8 each independently represent H, deuterium, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof;
  • symbol ## indicates the point of attachment to X₁; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-6), L₁ represents the structure of the following formula:

##—(C(R^a1)(R^a2))_m1—(O(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(O(C(R^a3)(R^a4))_m2)_p1—(O(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(O(C(R^a3)(R^a4))_m2)_p1—(O(C(R^a5)(R^a6))_m3)_p2—(O(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(N(R_g9)(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(N(R_g9)(C(R^a3)(R^a4))_m2)_p1—(N(R_g9)(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(N(R_g9)(C(R^a3)(R^a4))_m2)_p1—(N(R_g9)(C(R^a5)(R^a6))_m3)_p2—(N(R_g9)(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(C(O)NH—(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(C(O)NH—(C(R^a3)(R^a4))_m2)_p1—(C(O)NH—(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(C(O)NH—(C(R^a3)(R^a4))_m2)_p1—(C(O)NH—(C(R^a5)(R^a6))_m3)_p2—(C(O)NH—(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—(C(O)NH—(C(R^a3)(R^a4))_m2)_p1—(O—(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1(—C(O)NH—(C(R^a3)(R^a4))_m2—(O(C(R^a5)(R^a6))_m3)_p1—;

##—(C(R^a1)(R^a2))_m1—(NHC(O)—(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(NHC(O)—(C(R^a3)(R^a4))_m2)_p1—(—O—(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(NHC(O)—(C(R^a3)(R^a4))_m2)_p1—(O—(C(R^a5)(R^a6))_m3)_p2—(O—(C(R^a7)(R^a8))_m4)_p3—;

##—(C(R^a1)(R^a2))_m1—NHC(O)—(C(R^a3)(R^a4))_m2—(O(C(R^a5)(R^a6))_m3)_p1—;

##—(C(R^a1)(R^a2))_m1—NHC(O)NH—(C(R^a3)(R^a4))_m2—;

##—(C(R^a1)(R^a2))_m1—C(O)—(C(R^a3)(R^a4))_m2—;

##—(C(R^a1)(R^a2))_m1—C(S)—(C(R^a3)(R^a4))_m2—;

##—(C(R^a1)(R^a2))_m1—S—(C(R^a3)(R^a4))_m2—;

##—(C(R^a1)(R^a2))_m1—(C_6-10 arylene-(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1—(C_6-10 arylene-(C(R^a3)(R^a4))_m2)_p1—C_6-10 arylene-(C(R^a5)(R^a6))_m3—;

##—(C(R^a1)(R^a2))_m1-(4- to 15-membered heterocyclylene-(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1-(4- to 15-membered heterocyclylene-(C(R^a3)(R^a4))_m2)_p1-(4- to 15-membered heterocyclylene-(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1-(5- to 15-membered heteroarylene-(C(R^a3)(R^a4))_m2)_p1—;

##—(C(R^a1)(R^a2))_m1-(5- to 15-membered heteroarylene-(C(R^a3)(R^a4))_m2)_p1—(5- to 15-membered heteroarylene-(C(R^a5)(R^a6))_m3)_p2—;

##—(C(R^a1)(R^a2))_m1—(C_3-15cycloalkylene-(C(R^a3)(R^a4))_m2)_p1—; or

##—(C(R^a1)(R^a2))_m1—(C_3-15cycloalkylene-(C(R^a3)(R^a4))_m2)_p1—(C_3-15cycloalkylene-(C(R^a5)(R^a6))_m3)_p2—;

• • wherein each R₉ independently represents H or C_1-3 alkyl;
  • the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene and the triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a1, R^a2, R^a3, R^a4, R^a5, R^a6, R^a7 and R^a8 each independently represent H, deuterium, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof;
  • symbol ## indicates the point of attachment to X₁; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-6), L₁ represents the following group:

##—CH₂—O—CH₂—, ##—CH₂—O—(CH₂)₂—, ##—(CH₂)₁—O—(CH₂)₃—, ##—(CH₂)₁—O—(CH₂)₄—, ##—(CH₂)₁—O—(CH₂)₅—, ##—(CH₂)₁—O—(CH₂)₆—, ##—(CH₂)₁—O—(CH₂)₇—, ##—(CH₂)₁—O—(CH₂)₈—, ##—(CH₂)₁—O—(CH₂)₉—, ##—(CH₂)₁—O—(CH₂)₁₀—, ##—(CH₂)₂—O—(CH₂)₁—, ##—(CH₂)₂—O—(CH₂)₂—, ##—(CH₂)₂—O—(CH₂)₃—, ##—(CH₂)₂—O—(CH₂)₄—, ##—(CH₂)₂—O—(CH₂)₅—, ##—(CH₂)₂—O—(CH₂)₆—, ##—(CH₂)₂—O—(CH₂)₇—, ##—(CH₂)₂—O—(CH₂)₈—, ##—(CH₂)₂—O—(CH₂)₉—, ##—(CH₂)₂—O—(CH₂)₁₀—, ##—(CH₂)₂—O—(CH₂)₁₁—, ##—(CH₂)₂—O—(CH₂)₁₂—, ##—(CH₂)₃—O—(CH₂)₁—, ##—(CH₂)₃—O—(CH₂)₂—, ##—(CH₂)₃—O—(CH₂)₃—, ##—(CH₂)₃—O—(CH₂)₄—, ##—(CH₂)₃—O—(CH₂)₅—, ##—(CH₂)₃—O—(CH₂)₆—, ##—(CH₂)₃—O—(CH₂)₇—, ##—(CH₂)₄—O—(CH₂)₁—, ##—(CH₂)₄—O—(CH₂)₂—, ##—(CH₂)₄—O—(CH₂)₃—, ##—(CH₂)₄—O—(CH₂)₄—, ##—(CH₂)₄—O—(CH₂)₅—, ##—(CH₂)₄—O—(CH₂)₆—, ##—(CH₂)₅—O—(CH₂)₁—, ##—(CH₂)₅—O—(CH₂)₂—, ##—(CH₂)₅—O—(CH₂)₃—, ##—(CH₂)₅—O—(CH₂)₄—, ##—(CH₂)₅—O—(CH₂)₅—, ##—(CH₂)₆—O—(CH₂)₁—, ##—(CH₂)₆—O—(CH₂)₂—, ##—(CH₂)₆—O—(CH₂)₃—, ##—(CH₂)₆—O—(CH₂)₄—, ##—(CH₂)₇—O—(CH₂)₁—, ##—(CH₂)₇—O—(CH₂)₂—, ##—(CH₂)₇—O—(CH₂)₃—, ##—(CH₂)₈—O—(CH₂)₁—, ##—(CH₂)₈—O—(CH₂)₂—, ##—CH(CH₃)—O—(CH₂)₁—, ##—CH(CH₃)—O—(CH₂)₂—, ##—CH(CH₃)—O—(CH₂)₃—, ##—CH(CH₃)—O—(CH₂)₄—, ##—CH(CH₃)—O—(CH₂)₅—, ##—CH(CH₃)—O—(CH₂)₆—, ##—CH(CH₃)—O—(CH₂)₇—, ##—CH(CH₃)—O—(CH₂)₈—, ##—CH(CH₃)—O—(CH₂)₉—, ##—CH(CH₃)—O—(CH₂)₁₀—, ##—CH₂—(O(CH₂)₂)₂—, ##—CH₂—(O(CH₂)₂)₃—, ##—CH₂—(O(CH₂)₂)₄—, ##—CH₂—(O(CH₂)₂)₅—, ##—CH₂—(O(CH₂)₂)₆—, ##—CH₂—(O(CH₂)₂)₇—, ##—CH₂—(O(CH₂)₂)₈—, ##—CH₂—(O(CH₂)₂)₉—, ##—CH₂—(O(CH₂)₂)₁₀—, ##—CH₂—(O(CH₂)₂)₁—OCH₂—, ##—CH₂—(O(CH₂)₂)₂—OCH₂—, ##—CH₂—(O(CH₂)₂)₃—OCH₂—, ##—CH₂—(O(CH₂)₂)₄—OCH₂—, ##—CH₂—(O(CH₂)₂)₅—OCH₂—, ##—CH₂—(O(CH₂)₂)₆—OCH₂—, ##—CH₂—(O(CH₂)₂)₇—OCH₂—, ##—CH₂—(O(CH₂)₂)₈—OCH₂—, ##—CH₂—(O(CH₂)₂)₉—OCH₂—, ##—CH₂—(O(CH₂)₂)₁₀—OCH₂—, ##—(CH₂)₂—(O(CH₂)₂)₂—, ##—(CH₂)₂—(O(CH₂)₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₄—, ##—(CH₂)₂—(O(CH₂)₂)₅—, ##—(CH₂)₂—(O(CH₂)₂)₆—, ##—(CH₂)₂—(O(CH₂)₂)₇—, ##—(CH₂)₂—(O(CH₂)₂)₈—, ##—(CH₂)₂—(O(CH₂)₂)₉—, ##—(CH₂)₂—(O(CH₂)₂)₁₀—, ##—(CH₂)₃—(O(CH₂)₂)₂—, ##—(CH₂)₃—(O(CH₂)₂)₃—, ##—(CH₂)₃—(O(CH₂)₂)₄—, ##—(CH₂)₃—(O(CH₂)₂)₅—, ##—(CH₂)₃—(O(CH₂)₂)₆—, ##—(CH₂)₃—(O(CH₂)₂)₇—, ##—(CH₂)₃—(O(CH₂)₂)₈—, ##—(CH₂)₃—(O(CH₂)₂)₉—, ##—(CH₂)₃—(O(CH₂)₂)₁₀—, ##—(CH₂)₄—(O(CH₂)₂)₂—, ##—(CH₂)₄—(O(CH₂)₂)₃—, ##—(CH₂)₄—(O(CH₂)₂)₄—, ##—(CH₂)₄—(O(CH₂)₂)₅—, ##—(CH₂)₄—(O(CH₂)₂)₆—, ##—(CH₂)₄—(O(CH₂)₂)₇—, ##—(CH₂)₄—(O(CH₂)₂)₈—, ##—(CH₂)₄—(O(CH₂)₂)₉—, ##—(CH₂)₄—(O(CH₂)₂)₁₀—, ##—CH₂—(O(CH₂)₃)₂—, ##—CH₂—(O(CH₂)₃)₃—, ##—CH₂—(O(CH₂)₃)₄—, ##—CH₂—(O(CH₂)₃)₅—, ##—CH₂—(O(CH₂)₃)₆—, ##—CH₂—(O(CH₂)₃)₇—, ##—CH₂—(O(CH₂)₃)₈—, ##—CH₂—(O(CH₂)₃)₉—, ##—CH₂—(O(CH₂)₃)₁₀—, ##—(CH₂)₂—(O(CH₂)₃)₂—, ##—(CH₂)₂—(O(CH₂)₃)₃—, ##—(CH₂)₂—(O(CH₂)₃)₄—, ##—(CH₂)₂—(O(CH₂)₃)₅—, ##—(CH₂)₂—(O(CH₂)₃)₆—, ##—(CH₂)₂—(O(CH₂)₃)₇—, ##—(CH₂)₂—(O(CH₂)₃)₈—, ##—(CH₂)₂—(O(CH₂)₃)₉—, ##—(CH₂)₂—(O(CH₂)₃)₁₀—, ##—(CH₂)₃—(O(CH₂)₃)₂—, ##—(CH₂)₃—(O(CH₂)₃)₃—, ##—(CH₂)₃—(O(CH₂)₃)₄—, ##—(CH₂)₃—(O(CH₂)₃)₅—, ##—(CH₂)₃—(O(CH₂)₃)₆—, ##—(CH₂)₃—(O(CH₂)₃)₇—, ##—(CH₂)₃—(O(CH₂)₃)₈—, ##—(CH₂)₃—(O(CH₂)₃)₉—, ##—(CH₂)₃—(O(CH₂)₃)₁₀—, ##—CH₂—O—(CH₂)₂—O—(CH₂)₃—, ##—CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, ##—CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, ##—CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, ##—CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, ##—CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, ##—(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, ##—(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, ##—(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, ##—(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, ##—(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, ##—(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, ##—(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, ##—(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, ##—(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, ##—(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, ##—(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, ##—CH₂—O—(CH₂)₃—O—(CH₂)₂—, ##—CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, ##—CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, ##—CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, ##—CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, ##—CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, ##—(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, ##—(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, ##—(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, ##—(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, ##—(CH₂)₂—(O(CH₂)₃)₈—(O(CH₂)₂)₅—, ##—(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, ##—(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, ##—(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, ##—(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, ##—(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, ##—(CH₂)₃—(O(CH₂)₃)₈—(O(CH₂)₂)₅—, ##—(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, ##—CH₂—O—(CH₂)₂O—CH₂—, ##—(CH₂)₂—O—(CH₂)₂O—CH₂—, ##—(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, ##—(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, ##—(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, ##—(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, ##—CH₂—C(O)—CH₂—, ##—CH₂—C(O)—(CH₂)₂—, ##—(CH₂)₁—C(O)—(CH₂)₃—, ##—(CH₂)₁—C(O)—(CH₂)₄—, ##—(CH₂)₁—C(O)—(CH₂)₅—, ##—(CH₂)₁—C(O)—(CH₂)₆—, ##—(CH₂)₁—C(O)—(CH₂)₇—, ##—(CH₂)₁—C(O)—(CH₂)₈—, ##—(CH₂)₁—C(O)—(CH₂)₉—, ##—(CH₂)₁—C(O)—(CH₂)₁₀—, ##—(CH₂)₂—C(O)—(CH₂)₁—, ##—(CH₂)₂—C(O)—(CH₂)₂—, ##—(CH₂)₂—C(O)—(CH₂)₃—, ##—(CH₂)₂—C(O)—(CH₂)₄—, ##—(CH₂)₂—C(O)—(CH₂)₅—, ##—(CH₂)₂—C(O)—(CH₂)₆—, ##—(CH₂)₂—C(O)—(CH₂)₇—, ##—(CH₂)₂—C(O)—(CH₂)₈—, ##—(CH₂)₂—C(O)—(CH₂)₉—, ##—(CH₂)₂—C(O)—(CH₂)₁₀—, ##—(CH₂)₂—C(O)—(CH₂)₁₁—, ##—(CH₂)₂—C(O)—(CH₂)₁₂—, ##—(CH₂)₃—C(O)—(CH₂)₁—, ##—(CH₂)₃—C(O)—(CH₂)₂—, ##—(CH₂)₃—C(O)—(CH₂)₃—, ##—(CH₂)₃—C(O)—(CH₂)₄—, ##—(CH₂)₃—C(O)—(CH₂)₅—, ##—(CH₂)₃—C(O)—(CH₂)₆—, ##—(CH₂)₃—C(O)—(CH₂)₇—, ##—(CH₂)₄—C(O)—(CH₂)₁—, ##—(CH₂)₄—C(O)—(CH₂)₂—, ##—(CH₂)₄—C(O)—(CH₂)₃—, ##—(CH₂)₄—C(O)—(CH₂)₄—, ##—(CH₂)₄—C(O)—(CH₂)₅—, ##—(CH₂)₄—C(O)—(CH₂)₆—, ##—(CH₂)₅—C(O)—(CH₂)₁—, ##—(CH₂)₅—C(O)—(CH₂)₂—, ##—(CH₂)₅—C(O)—(CH₂)₃—, ##—(CH₂)₅—C(O)—(CH₂)₄—, ##—(CH₂)₅—C(O)—(CH₂)₅—, ##—(CH₂)₆—C(O)—(CH₂)₁—, ##—(CH₂)₆—C(O)—(CH₂)₂—, ##—(CH₂)₆—C(O)—(CH₂)₃—, ##—(CH₂)₆—C(O)—(CH₂)₄—, ##—(CH₂)₇—C(O)—(CH₂)₁—, ##—(CH₂)₇—C(O)—(CH₂)₂—, ##—(CH₂)₇—C(O)—(CH₂)₃—, ##—(CH₂)₈—C(O)—(CH₂)₁—, ##—(CH₂)₈—C(O)—(CH₂)₂—, ##—CH₂—S—CH₂—, ##—CH₂—S—(CH₂)₂—, ##—(CH₂)₁—S—(CH₂)₃—, ##—(CH₂)₁—S—(CH₂)₄—, ##—(CH₂)₁—S—(CH₂)₅—, ##—(CH₂)₁—S—(CH₂)₆—, ##—(CH₂)₁—S—(CH₂)₇—, ##—(CH₂)₁—S—(CH₂)₈—, ##—(CH₂)₁—S—(CH₂)₉—, ##—(CH₂)₁—S—(CH₂)₁₀—, ##—(CH₂)₂—S—(CH₂)₁—, ##—(CH₂)₂—S—(CH₂)₂—, ##—(CH₂)₂—S—(CH₂)₃—, ##—(CH₂)₂—S—(CH₂)₄—, ##—(CH₂)₂—S—(CH₂)₅—, ##—(CH₂)₂—S—(CH₂)₆—, ##—(CH₂)₂—S—(CH₂)₇—, ##—(CH₂)₂—S—(CH₂)₈—, ##—(CH₂)₂—S—(CH₂)₉—, ##—(CH₂)₂—S—(CH₂)₁₀—, ##—(CH₂)₂—S—(CH₂)₁₁—, ##—(CH₂)₂—S—(CH₂)₁₂—, ##—(CH₂)₃—S—(CH₂)₁—, ##—(CH₂)₃—S—(CH₂)₂—, ##—(CH₂)₃—S—(CH₂)₃—, ##—(CH₂)₃—S—(CH₂)₄—, ##—(CH₂)₃—S—(CH₂)₅—, ##—(CH₂)₃—S—(CH₂)₆—, ##—(CH₂)₃—S—(CH₂)₇—, ##—(CH₂)₄—S—(CH₂)₁—, ##—(CH₂)₄—S—(CH₂)₂—, ##—(CH₂)₄—S—(CH₂)₃—, ##—(CH₂)₄—S—(CH₂)₄—, ##—(CH₂)₄—S—(CH₂)₅—, ##—(CH₂)₄—S—(CH₂)₆—, ##—(CH₂)₅—S—(CH₂)₁—, ##—(CH₂)₅—S—(CH₂)₂—, ##—(CH₂)₅—S—(CH₂)₃—, ##—(CH₂)₅—S—(CH₂)₄—, ##—(CH₂)₅—S—(CH₂)₅—, ##—(CH₂)₆—S—(CH₂)₁—, ##—(CH₂)₆—S—(CH₂)₂—, ##—(CH₂)₆—S—(CH₂)₃—, ##—(CH₂)₆—S—(CH₂)₄—, ##—(CH₂)₇—S—(CH₂)₁—, ##—(CH₂)₇—S—(CH₂)₂—, ##—(CH₂)₇—S—(CH₂)₃—, ##—(CH₂)₈—S—(CH₂)₁—, ##—(CH₂)₈—S—(CH₂)₂—, ##—CH₂—C(S)—CH₂—, ##—CH₂—C(S)—(CH₂)₂—, ##—(CH₂)₁—C(S)—(CH₂)₃—, ##—(CH₂)₁—C(S)—(CH₂)₄—, ##—(CH₂)₁—C(S)—(CH₂)₅—, ##—(CH₂)₁—C(S)—(CH₂)₆—, ##—(CH₂)₁—C(S)—(CH₂)₇—, ##—(CH₂)₁—C(S)—(CH₂)₈—, ##—(CH₂)₁—C(S)—(CH₂)₉—, ##—(CH₂)₁—C(S)—(CH₂)₁₀—, ##—(CH₂)₂—C(S)—(CH₂)₁—, ##—(CH₂)₂—C(S)—(CH₂)₂—, ##—(CH₂)₂—C(S)—(CH₂)₃—, ##—(CH₂)₂—C(S)—(CH₂)₄—, ##—(CH₂)₂—C(S)—(CH₂)₅—, ##—(CH₂)₂—C(S)—(CH₂)₆—, ##—(CH₂)₂—C(S)—(CH₂)₇—, ##—(CH₂)₂—C(S)—(CH₂)₈—, ##—(CH₂)₂—C(S)—(CH₂)₉—, ##—(CH₂)₂—C(S)—(CH₂)₁₀—, ##—(CH₂)₂—C(S)—(CH₂)₁₁—, ##—(CH₂)₂—C(S)—(CH₂)₁₂—, ##—(CH₂)₃—C(S)—(CH₂)₁—, ##—(CH₂)₃—C(S)—(CH₂)₂—, ##—(CH₂)₃—C(S)—(CH₂)₃—, ##—(CH₂)₃—C(S)—(CH₂)₄—, ##—(CH₂)₃—C(S)—(CH₂)₅—, ##—(CH₂)₃—C(S)—(CH₂)₆—, ##—(CH₂)₃—C(S)—(CH₂)₇—, ##—(CH₂)₄—C(S)—(CH₂)₁—, ##—(CH₂)₄—C(S)—(CH₂)₂—, ##—(CH₂)₄—C(S)—(CH₂)₃—, ##—(CH₂)₄—C(S)—(CH₂)₄—, ##—(CH₂)₄—C(S)—(CH₂)₅—, ##—(CH₂)₄—C(S)—(CH₂)₆—, ##—(CH₂)₅—C(S)—(CH₂)₁—, ##—(CH₂)₅—C(S)—(CH₂)₂—, ##—(CH₂)₅—C(S)—(CH₂)₃—, ##—(CH₂)₅—C(S)—(CH₂)₄—, ##—(CH₂)₅—C(S)—(CH₂)₅—, ##—(CH₂)₆—C(S)—(CH₂)₁—, ##—(CH₂)₆—C(S)—(CH₂)₂—, ##—(CH₂)₆—C(S)—(CH₂)₃—, ##—(CH₂)₆—C(S)—(CH₂)₄—, ##—(CH₂)₇—C(S)—(CH₂)₁—, ##—(CH₂)₇—C(S)—(CH₂)₂—, ##—(CH₂)₇—C(S)—(CH₂)₃—, ##—(CH₂)₈—C(S)—(CH₂)₁—, ##—(CH₂)₈—C(S)—(CH₂)₂—, ##—CH₂—C(O)O—CH₂—, ##—CH₂—C(O)O—(CH₂)₂—, ##—(CH₂)₁—C(O)O—(CH₂)₃—, ##—(CH₂)₁—C(O)O—(CH₂)₄—, ##—(CH₂)₁—C(O)O—(CH₂)₅—, ##—(CH₂)₁—C(O)O—(CH₂)₆—, ##—(CH₂)₁—C(O)O—(CH₂)₇—, ##—(CH₂)₁—C(O)O—(CH₂)₈—, ##—(CH₂)₁—C(O)O—(CH₂)₉—, ##—(CH₂)₁—C(O)O—(CH₂)₁₀—, ##—(CH₂)₂—C(O)O—(CH₂)₁—, ##—(CH₂)₂—C(O)O—(CH₂)₂—, ##—(CH₂)₂—C(O)O—(CH₂)₃—, ##—(CH₂)₂—C(O)O—(CH₂)₄—, ##—(CH₂)₂—C(O)O—(CH₂)₅—, ##—(CH₂)₂—C(O)O—(CH₂)₆—, ##—(CH₂)₂—C(O)O—(CH₂)₇—, ##—(CH₂)₂—C(O)O—(CH₂)₈—, ##—(CH₂)₂—C(O)O—(CH₂)₉—, ##—(CH₂)₂—C(O)O—(CH₂)₁₀—, ##—(CH₂)₂—C(O)O—(CH₂)₁₁—, ##—(CH₂)₂—C(O)O—(CH₂)₁₂—, ##—(CH₂)₃—C(O)O—(CH₂)₁—, ##—(CH₂)₃—C(O)O—(CH₂)₂—, ##—(CH₂)₃—C(O)O—(CH₂)₃—, ##—(CH₂)₃—C(O)O—(CH₂)₄—, ##—(CH₂)₃—C(O)O—(CH₂)₅—, ##—(CH₂)₃—C(O)O—(CH₂)₆—, ##—(CH₂)₃—C(O)O—(CH₂)₇—, ##—(CH₂)₄—C(O)O—(CH₂)₁—, ##—(CH₂)₄—C(O)O—(CH₂)₂—, ##—(CH₂)₄—C(O)O—(CH₂)₃—, ##—(CH₂)₄—C(O)O—(CH₂)₄—, ##—(CH₂)₄—C(O)O—(CH₂)₅—, ##—(CH₂)₄—C(O)O—(CH₂)₆—, ##—(CH₂)₅—C(O)O—(CH₂)₁—, ##—(CH₂)₅—C(O)O—(CH₂)₂—, ##—(CH₂)₅—C(O)O—(CH₂)₃—, ##—(CH₂)₅—C(O)O—(CH₂)₄—, ##—(CH₂)₅—C(O)O—(CH₂)₅—, ##—(CH₂)₆—C(O)O—(CH₂)₁—, ##—(CH₂)₆—C(O)O—(CH₂)₂—, ##—(CH₂)₆—C(O)O—(CH₂)₃—, ##—(CH₂)₆—C(O)O—(CH₂)₄—, ##—(CH₂)₇—C(O)O—(CH₂)₁—, ##—(CH₂)₇—C(O)O—(CH₂)₂—, ##—(CH₂)₇—C(O)O—(CH₂)₃—, ##—(CH₂)₈—C(O)O—(CH₂)₁—, ##—(CH₂)₈—C(O)O—(CH₂)₂—, ##—CH₂—OC(O)—CH₂—, ##—CH₂—OC(O)—(CH₂)₂—, ##—(CH₂)₁—OC(O)—(CH₂)₃—, ##—(CH₂)₁—OC(O)—(CH₂)₄—, ##—(CH₂)₁—OC(O)—(CH₂)₅—, ##—(CH₂)₁—OC(O)—(CH₂)₆—, ##—(CH₂)₁—OC(O)—(CH₂)₇—, ##—(CH₂)₁—OC(O)—(CH₂)₈—, ##—(CH₂)₁—OC(O)—(CH₂)₉—, ##—(CH₂)₁—OC(O)—(CH₂)₁₀—, ##—(CH₂)₂—OC(O)—(CH₂)₁—, ##—(CH₂)₂—OC(O)—(CH₂)₂—, ##—(CH₂)₂—OC(O)—(CH₂)₃—, ##—(CH₂)₂—OC(O)—(CH₂)₄—, ##—(CH₂)₂—OC(O)—(CH₂)₅—, ##—(CH₂)₂—OC(O)—(CH₂)₆—, ##—(CH₂)₂—OC(O)—(CH₂)₇—, ##—(CH₂)₂—OC(O)—(CH₂)₈—, ##—(CH₂)₂—OC(O)—(CH₂)₉—, ##—(CH₂)₂—OC(O)—(CH₂)₁₀—, ##—(CH₂)₂—OC(O)—(CH₂)₁₁—, ##—(CH₂)₂—OC(O)—(CH₂)₁₂—, ##—(CH₂)₃—OC(O)—(CH₂)₁—, ##—(CH₂)₃—OC(O)—(CH₂)₂—, ##—(CH₂)₃—OC(O)—(CH₂)₃—, ##—(CH₂)₃—OC(O)—(CH₂)₄—, ##—(CH₂)₃—OC(O)—(CH₂)₅—, ##—(CH₂)₃—OC(O)—(CH₂)₆—, ##—(CH₂)₃—OC(O)—(CH₂)₇—, ##—(CH₂)₄—OC(O)—(CH₂)₁—, ##—(CH₂)₄—OC(O)—(CH₂)₂—, ##—(CH₂)₄—OC(O)—(CH₂)₃—, ##—(CH₂)₄—OC(O)—(CH₂)₄—, ##—(CH₂)₄—OC(O)—(CH₂)₅—, ##—(CH₂)₄—OC(O)—(CH₂)₆—, ##—(CH₂)₅—OC(O)—(CH₂)₁—, ##—(CH₂)₅—OC(O)—(CH₂)₂—, ##—(CH₂)₅—OC(O)—(CH₂)₃—, ##—(CH₂)₅—OC(O)—(CH₂)₄—, ##—(CH₂)₅—OC(O)—(CH₂)₅—, ##—(CH₂)₆—OC(O)—(CH₂)₁—, ##—(CH₂)₆—OC(O)—(CH₂)₂—, ##—(CH₂)₆—OC(O)—(CH₂)₃—, ##—(CH₂)₆—OC(O)—(CH₂)₄—, ##—(CH₂)₇—OC(O)—(CH₂)₁—, ##—(CH₂)₇—OC(O)—(CH₂)₂—, ##—(CH₂)₇—OC(O)—(CH₂)₃—, ##—(CH₂)₈—OC(O)—(CH₂)₁—, ##—(CH₂)₈—OC(O)—(CH₂)₂—, ##—(CH₂)₁—N(R_g10)—(CH₂)₁—, ##—(CH₂)₁—N(R_g10)—(CH₂)₂—, ##—(CH₂)₁—N(R_g10)—(CH₂)₃—, ##—(CH₂)₁—N(R_g10)—(CH₂)₄—, ##—(CH₂)₁—N(R_g10)—(CH₂)₅—, ##—(CH₂)₁—N(R_g10)—(CH₂)₆—, ##—(CH₂)₁—N(R_g10)—(CH₂)₇—, ##—(CH₂)₁—N(R_g10)—(CH₂)₈—, ##—(CH₂)₁—N(R_g10)—(CH₂)₉—, ##—(CH₂)₁—N(R_g10)—(CH₂)₁₀—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁—, ##—(CH₂)₂—N(R_g10)—(CH₂)₂—, ##—(CH₂)₂—N(R_g10)—(CH₂)₃—, ##—(CH₂)₂—N(R_g10)—(CH₂)₄—, ##—(CH₂)₂—N(R_g10)—(CH₂)₅—, ##—(CH₂)₂—N(R_g10)—(CH₂)₆—, ##—(CH₂)₂—N(R_g10)—(CH₂)₇—, ##—(CH₂)₂—N(R_g10)—(CH₂)₈—, ##—(CH₂)₂—N(R_g10)—(CH₂)₉—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁₀—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁₁—, ##—(CH₂)₂—N(R_g10)—(CH₂)₁₂—, ##—(CH₂)₃—N(R_g10)—(CH₂)₁—, ##—(CH₂)₃—N(R_g10)—(CH₂)₂—, ##—(CH₂)₃—N(R_g10)—(CH₂)₃—, ##—(CH₂)₄—N(R_g10)—(CH₂)₁—, ##—(CH₂)₄—N(R_g10)—(CH₂)₂—, ##—(CH₂)₄—N(R_g10)—(CH₂)₃—, ##—(CH₂)₄—N(R_g10)—(CH₂)₄—, ##—(CH₂)₅—N(R_g10)—(CH₂)₁—, ##—(CH₂)₅—N(R_g10)—(CH₂)₂—, ##—(CH₂)₅—N(R_g10)—(CH₂)₃—, ##—(CH₂)₅—N(R_g10)—(CH₂)₄—, ##—(CH₂)₅—N(R_g10)—(CH₂)₅—, ##—(CH₂)₆—N(R_g10)—(CH₂)₁—, ##—(CH₂)₆—N(R_g10)—(CH₂)₂—, ##—(CH₂)₆—N(R_g10)—(CH₂)₃—, ##—(CH₂)₇—N(R_g10)—(CH₂)₁—, ##—(CH₂)₇—N(R_g10)—(CH₂)₂—, ##—(CH₂)₇—N(R_g10)—(CH₂)₃—, ##—(CH₂)₈—N(R_g10)—(CH₂)₁—, ##—(CH₂)₈—NR_g10)—(CH₂)₂—, ##—(CH₂)₈—N(R_g10)—(CH₂)₃—, ##—CH(CH₃)—N(R_g10)—(CH₂)₁—, ##—CH(CH₃)—N(R_g10)—(CH₂)₂—, ##—CH(CH₃)—N(R_g10)—(CH₂)₃—, ##—CH(CH₃)—N(R_g10)—(CH₂)₄—, ##—CH(CH₃)—N(R_g10)—(CH₂)₅—, ##—CH(CH₃)—N(R_g10)—(CH₂)₆—, ##—CH(CH₃)—N(R_g10)—(CH₂)₇—, ##—CH(CH₃)—N(R_g10)—(CH₂)₈—, ##—CH(CH₃)—N(R_g10)—(CH₂)₉—, ##—CH(CH₃)—N(R_g10)—(CH₂)₁₀—, ##—CH₂C(O)NHCH₂—, ##—(CH₂)₂C(O)NH(CH₂)₂—, ##—(CH₂)₂C(O)NH(CH₂)₃—, ##—(CH₂)₂C(O)NH(CH₂)₄—, ##—(CH₂)₂C(O)NH(CH₂)₅—, ##—(CH₂)₃C(O)NH(CH₂)₃—, ##—(CH₂)₃C(O)NH(CH₂)₄—, ##—(CH₂)₄C(O)NH(CH₂)₄—, ##—(CH₂)₅C(O)NH(CH₂)₅—, ##—(CH₂)₇C(O)NH(CH₂)₇—, ##—(CH₂)₆C(O)NH(CH₂)₆—, ##—(CH₂)₇C(O)NH(CH₂)₇—, ##—(CH₂)₈C(O)NH(CH₂)₈, ##—(CH₂)₉C(O)NH(CH₂)₉—, ##—(CH₂)₁₀C(O)NH(CH₂)₁₀—, ##—(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, ##—CH₂NHC(O)CH₂—, ##—(CH₂)₂NHC(O)(CH₂)₂—, ##—(CH₂)₂NHC(O)(CH₂)₃—, ##—(CH₂)₂NHC(O)(CH₂)₄—, ##—(CH₂)₂NHC(O)(CH₂)₅—, ##—(CH₂)₃NHC(O)(CH₂)₃—, ##—(CH₂)₃NHC(O)(CH₂)₄—, ##—(CH₂)₄NHC(O₎(CH₂)₄—, ##—(CH₂)₅NHC(O)(CH₂)₅—, ##—(CH₂)₇NHC(O)(CH₂)₇—, ##—(CH₂)₆NHC(O)(CH₂)₆—, ##—(CH₂)₇NHC(O)(CH₂)₇—, ##—(CH₂)₈NHC(O)(CH₂)₈, ##—(CH₂)₉NHC(O)(CH₂)₉—, ##—(CH₂)₁₀NHC(O)(CH₂)₁₀—, ##—(CH₂)₄NHC(O)(CH₂)₈—, ##—(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, ##—(CH₂)₄NHC(O)CH₂—, ##—CH₂-piperidinylene-CH₂—, ##—CH₂-piperidinylene-(CH₂)₂—, ##—CH₂-piperidinylene-(CH₂)₃—, ##—CH₂-piperidinylene-(CH₂)₄—, ##—CH₂-piperidinylene-(CH₂)₅—, ##—CH₂-piperidinylene-(CH₂)₆—, ##—CH₂-piperidinylene-(CH₂)₇—, ##—CH₂-piperidinylene-(CH₂)₈—, ##—(CH₂)₂-piperidinylene-(CH₂)₁—, ##—(CH₂)₂-piperidinylene-(CH₂)₂—, ##—(CH₂)₂-piperidinylene-(CH₂)₃—, ##—(CH₂)₂-piperidinylene-(CH₂)₄—, ##—(CH₂)₂-piperidinylene-(CH₂)₅—, ##—(CH₂)₂-piperidinylene-(CH₂)₆—, ##—(CH₂)₂-piperidinylene-(CH₂)₂—, ##—(CH₂)₂-piperidinylene-(CH₂)₈—, ##—(CH₂)₃-piperidinylene-CH₂—, ##—(CH₂)₃-piperidinylene-(CH₂)₂—, ##—(CH₂)₃-piperidinylene-(CH₂)₃—, ##—(CH₂)₃-piperidinylene-(CH₂)₄—, ##—(CH₂)₃-piperidinylene-(CH₂)₅—, ##—(CH₂)₃-piperidinylene-(CH₂)₆—, ##—(CH₂)₃-piperidinylene-(CH₂)₂—, ##—(CH₂)₃-piperidinylene-(CH₂)₈—, ##—(CH₂)₄-piperidinylene-CH₂—, ##—(CH₂)₄-piperidinylene-(CH₂)₂—, ##—(CH₂)₄-piperidinylene-(CH₂)₃—, ##—(CH₂)₄-piperidinylene-(CH₂)₄—, ##—(CH₂)₄-piperidinylene-(CH₂)₅—, ##—(CH₂)₄-piperidinylene-(CH₂)₆—, ##—(CH₂)₄-piperidinylene-(CH₂)₇—, ##—(CH₂)₄-piperidinylene ##—(CH₂)₅-piperidinylene-(CH₂)₁—, ##—(CH₂)₅-piperidinylene-(CH₂)₂—, ##—(CH₂)₅-piperidinylene-(CH₂)₃—, ##—(CH₂)₅-piperidinylene-(CH₂)₄—, ##—(CH₂)₅-piperidinylene-(CH₂)₅—, ##—(CH₂)₅-piperidinylene-(CH₂)₆—, ##—(CH₂)₅-piperidinylene-(CH₂)₇—, ##—(CH₂)₅-piperidinylene-(CH₂)₈—, ##—(CH₂)₆-piperidinylene-(CH₂)₁—, ##—(CH₂)₆-piperidinylene-(CH₂)₂—, ##-(CH₂)₆-piperidinylene-(CH₂)₃—, ##—(CH₂)₆-piperidinylene-(CH₂)₄—, ##—(CH₂)₆-piperidinylene-(CH₂)₅—, ##—(CH₂)₆-piperidinylene-(CH₂)₆—, ##—(CH₂)₆-piperidinylene-(CH₂)₇—, ##—(CH₂)₆-piperidinylene-(CH₂)₈—, ##—(CH₂)₇-piperidinylene-(CH₂)₁—, ##—(CH₂)₇-piperidinylene-(CH₂)₂—, ##—(CH₂)₇-piperidinylene-(CH₂)₃—, ##—(CH₂)₇-piperidinylene-(CH₂)₄—, ##—(CH₂)₇-piperidinylene-(CH₂)₈—, ##—(CH₂)₈-piperidinylene-CH₂—, ##—(CH₂)₈-piperidinylene-(CH₂)₂—, ##—(CH₂)₈-piperidinylene-(CH₂)₃—, ##—(CH₂)₈-piperidinylene-(CH₂)₄—, ##—(CH₂)₈-piperidinylene-(CH₂)₅—, ##—(CH₂)₈-piperidinylene-(CH₂)₆—, ##—(CH₂)₈-piperidinylene-(CH₂)₇—, ##—(CH₂)₈-piperidinylene-(CH₂)₈—, ##—CH₂-piperazinylene-CH₂—, ##—CH₂-piperazinylene-(CH₂)₂—, ##—CH₂-piperazinylene-(CH₂)₃—, ##—CH₂-piperazinylene-(CH₂)₄—, ##—CH₂-piperazinylene-(CH₂)—, ##—CH₂-piperazinylene-(CH₂)₆—, ##—CH₂-piperazinylene-(CH₂)₇—, ##—CH₂-piperazinylene-(CH₂)₈—, ##—(CH₂)₂-piperazinylene-(CH₂)₁—, ##—(CH₂)₂-piperazinylene-(CH₂)₂—, ##—(CH₂)₂-piperazinylene-(CH₂)₃—, ##—(CH₂)₂-piperazinylene-(CH₂)₄—, ##—(CH₂)₂-piperazinylene-(CH₂)—, ##—(CH₂)₂-piperazinylene-(CH₂)₆—, ##—(CH₂)₂-piperazinylene-(CH₂)₂—, ##—(CH₂)₂-piperazinylene-(CH₂)₅—, ##—(CH₂)₃-piperazinylene-CH₂-##—(CH₂)₃-piperazinylene-(CH₂)₂—, ##—(CH₂)₃-piperazinylene-(CH₂)₃-piperazinylene-(CH₂)₄—, ##—(CH₂)₃-piperazinylene-(CH₂)₅—, ##—(CH₂)₃-piperazinylene-(CH₂)₆—, ##—(CH₂)₃-piperazinylene-(CH₂)₇—, ##—(CH₂)₃-piperazinylene-(CH₂)₈—, ##—(CH₂)₄-piperazinylene-CH₂—, ##—(CH₂)₄-piperazinylene-(CH₂)₂—, ##—(CH₂)₄-piperazinylene-(CH₂)₃—, ##—(CH₂)₄-piperazinylene-(CH₂)₄—, ##—(CH₂)₄-piperazinylene-(CH₂)₅—, ##—(CH₂)₄-piperazinylene-(CH₂)₆—, ##—(CH₂)₄-piperazinylene-(CH₂)₇—, ##—(CH₂)₄-piperazinylene-(CH₂)₅—, ##—(CH₂)₅-piperazinylene-(CH₂)₁—, ##—(CH₂)₅-piperazinylene-(CH₂)₂—, ##—(CH₂)₅-piperazinylene-(CH₂)₃—, ##—(CH₂)₅-piperazinylene-(CH₂)₄—, ##—(CH₂)₅-piperazinylene-(CH₂)₅—, ##—(CH₂)₅-piperazinylene-(CH₂)₆—, ##—(CH₂)₅-piperazinylene-(CH₂)₇—, ##—(CH₂)₅-piperazinylene-(CH₂)₅—, ##—(CH₂)₆-piperazinylene-(CH₂)₁—, ##—(CH₂)₆-piperazinylene-(CH₂)₂—, ##—(CH₂)₆-piperazinylene-(CH₂)₃—, ##—(CH₂)₆-piperazinylene-(CH₂)₄—, ##—(CH₂)₆-piperazinylene-(CH₂)₅—, ##—(CH₂)₆-piperazinylene-(CH₂)₆—, ##—(CH₂)₆-piperazinylene-(CH₂)₇—, ##—(CH₂)₆-piperazinylene-(CH₂)₈—, ##—(CH₂)₇-piperazinylene-(CH₂)₁—, ##—(CH₂)₇-piperazinylene-(CH₂)₂—, ##—(CH₂)₇-piperazinylene-(CH₂)₃—, ##—(CH₂)₇-piperazinylene-(CH₂)₄—, ##—(CH₂)₇-piperazinylene-(CH₂)₅—, ##—(CH₂)₈-piperazinylene-CH₂—, ##—(CH₂)₈-piperazinylene-(CH₂)₂—, ##—(CH₂)₈-piperazinylene-(CH₂)₃—, ##—(CH₂)₈-piperazinylene-(CH₂)₄—, ##—(CH₂)₈-piperazinylene-(CH₂)₅—, ##—(CH₂)₈-piperazinylene-(CH₂)₆—, ##—(CH₂)₈-piperazinylene-(CH₂)₇—, ##—(CH₂)₈-piperazinylene-(CH₂)₈—, ##—CH₂-propylene-CH₂—, ##—CH₂-propylene-(CH₂)₂—, ##—CH₂-propylene-(CH₂)₃—, ##—CH₂-propylene-(CH₂)₄—, ##—CH₂-propylene-(CH₂)₅—, ##—CH₂-propylene-(CH₂)₆—, ##—CH₂-propylene-(CH₂)₇—, ##—CH₂-propylene-(CH₂)₈—, ##—(CH₂)₂-propylene-(CH₂)₁—, ##—(CH₂)₂-propylene-(CH₂)₂—, ##—(CH₂)₂-propylene- (CH₂)₃—, ##—(CH₂)₂-propylene-(CH₂)₄—, ##—(CH₂)₂-propylene-(CH₂)₅—, ##—(CH₂)₂-propylene-(CH₂)₆—, ##—(CH₂)₂-propylene-(CH₂)₇—, ##—(CH₂)₂-propylene-(CH₂)₈—, ##—(CH₂)₃-propylene-CH₂—, ##—(CH₂)₃-propylene-(CH₂)₂—, ##—(CH₂)₃-propylene-(CH₂)₃—, ##—(CH₂)₃-propylene-(CH₂)₄—, ##—(CH₂)₃-propylene- (CH₂)₅—, ##—(CH₂)₃-propylene-(CH₂)₆—, ##—(CH₂)₃-propylene-(CH₂)₇—, ##—(CH₂)₃-propylene-(CH₂)₈—, ##—(CH₂)₄-propylene-CH₂—, ##—(CH₂)₄-propylene-(CH₂)₂—, ##—(CH₂)₄-propylene-(CH₂)₃—, ##—(CH₂)₄-propylene-(CH₂)₄—, ##—(CH₂)₄-propylene-(CH₂)₅—, ##—(CH₂)₄-propylene-(CH₂)₆—, ##—(CH₂)₄-propylene- (CH₂)₇—, ##—(CH₂)₄-propylene-(CH₂)₈—, ##—(CH₂)₅-propylene-(CH₂)₁—, ##—(CH₂)₅-propylene-(CH₂)₂—, ##—(CH₂)₅-propylene-(CH₂)₃—, ##—(CH₂)₅-propylene-(CH₂)₄—, ##—(CH₂)₅-propylene-(CH₂)₅—, ##—(CH₂)₅-propylene-(CH₂)₆—, ##—(CH₂)₅-propylene-(CH₂)₇—, ##—(CH₂)₅-propylene-(CH₂)₈—, ##—(CH₂)₆-propylene- (CH₂)₁—, ##—(CH₂)₆-propylene-(CH₂)₂—, ##—(CH₂)₆-propylene-(CH₂)₃—, ##—(CH₂)₆-propylene-(CH₂)₄—, ##—(CH₂)₆-propylene-(CH₂)₅—, ##—(CH₂)₆-propylene-(CH₂)₆—, ##—(CH₂)₆-propylene-(CH₂)₇—, ##—(CH₂)₆-propylene-(CH₂)₈—, ##—(CH₂)₇-propylene-(CH₂)₁—, ##—(CH₂)₇-propylene-(CH₂)₂—, ##—(CH₂)₇-propylene- (CH₂)₃—, ##—(CH₂)₇-propylene-(CH₂)₄—, ##—(CH₂)₇-propylene-(CH₂)₅—, ##—(CH₂)₈-propylene-CH₂—, ##—(CH₂)₈-propylene-(CH₂)₂—, ##—(CH₂)₈-propylene-(CH₂)₃—, ##—(CH₂)₈-propylene-(CH₂)₄—, ##—(CH₂)₈-propylene-(CH₂)₅—, ##—(CH₂)₈-propylene-(CH₂)₆—, ##—(CH₂)₈-propylene-(CH₂)₇—, ##—(CH₂)₈-propylene- (CH₂)₈—, ##—CH₂-diazacycloheptanylene-CH₂—, ##—CH₂-diazacycloheptanylene-(CH₂)₂—, ##—CH₂-diazacycloheptanylene-(CH₂)₃—, ##—CH₂-diazacycloheptanylene-(CH₂)₄—, ##—CH₂-diazacycloheptanylene-(CH₂)₅—, ##—CH₂-diazacycloheptanylene-(CH₂)₆—, ##—CH₂-diazacycloheptanylene-(CH₂)₇—, ##—CH₂-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₃-diazacycloheptanylene-CH₂—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₄-diazacycloheptanylene-CH₂—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₅-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, ##—(CH₂)₈-diazacycloheptanylene-CH₂—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₆—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, ##—(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, ##—(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, ##—(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, ##—CH₂-diazabicyclo[3.2.1]octylene-CH₂—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, ##—(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₈—, ##—CH₂-diazabicyclo[2.2.2]octylene-CH₂—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, ##—(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-CH₂—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₄—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₆—, ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or ##—(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₈—;

• • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • each R_g10 independently represents H or C_1-3 alkyl; and
  • symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-6), L₁ represents the following group:

wherein symbol ## indicates the point of attachment to X₁.

In some embodiments of the compound of Formula (I-6), R_b represents C_1-60 alkyl optionally substituted with D or halogen.

In some embodiments of the compound of Formula (I-6), R_b represents the following group:

• • CH₃, CF₃, CD₃, CH₂CH₃, —(CH₂)₂—CH₃, —(CH₂)₃—CH₃, —(CH₂)₄—CH₃, —(CH₂)₅—CH₃, —(CH₂)₆—CH₃, —(CH₂)₇—CH₃, —(CH₂)₈—CH₃, —(CH₂)₉—CH₃, —(CH₂)₁₀—CH₃, —(CH₂)₁₁—CH₃, —(CH₂)₁₂—CH₃, —(CH₂)₁₃—CH₃, —(CH₂)₁₄—CH₃, —(CH₂)₁₅—CH₃, —(CH₂)₁₆—CH₃, —(CH₂)₁₇—CH₃, —(CH₂)₁₈—CH₃, —(CH₂)₁₉—CH₃, —(CH₂)₂₀—CH₃, —(CH₂)₂₁—CH₃, —(CH₂)₂₂—CH₃, —(CH₂)₂₃—CH₃, —(CH₂)₂₄—CH₃, —(CH₂)₂₅—CH₃, —(CH₂)₂₆—CH₃, —(CH₂)₂₇—CH₃, —(CH₂)₂₈—CH₃, or —(CH₂)₂₉—CH₃.

In some embodiments of the compound of Formula (I-6), R_b represents the following formula:

R_b1—X₄-L₂-,

• • wherein L₂ represents:
    • linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene)
    • optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof, or optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃ or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of C_3-15cycloalkylene, 4- to 15-membered heterocyclylene, C_6-10 arylene, 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene, C_6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and the linear or branched C_2-60 alkylene is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof;
  • X₄ represents a bond, or X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted C_3-20cycloalkylene, optionally substituted C_6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, and the C_3-20cycloalkylene, the C_6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; and
  • R_b1 represents optionally substituted C_3-20cycloalkyl, optionally substituted C_6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C_3-20cycloalkyl, the C_6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, C_1-3 alkoxy (e.g., methoxy, ethoxy, or propoxy), C_1-3 alkyl-NH— (e.g., CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-3 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-3 alkylene (e.g., NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-3 alkyl-NHC(O)— (e.g., CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-3 alkyl-C(O)NH— (e.g., CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), cyano or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-6), L₂ represents the structure of the following formula: —C_2-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (1-6), L₂ represents the following group:

• • —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₂—CF₂—(CH₂)₂—, —(CH₂)₆—, —(CH₂)₇—, —(CH₂)₈—, —(CH₂)₉—, —(CH₂)₁₀—, —(CH₂)₁₁—, —(CH₂)₁₂—, —(CH₂)₁₃—, —(CH₂)₁₄—, —(CH₂)₁₅—, —(CH₂)₁₆—, —(CH₂)₁₇—, —(CH₂)₁₈—, —(CH₂)₁₉—, —(CH₂)₂₀—, —(CH₂)₂₁—, —(CH₂)₂₂—, —(CH₂)₂₅—, or —(CH₂)₃₀—;
  • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the group is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (I-6), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—(R₁₂(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—(R₁₃(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₂—R₁₃—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃—R₁₂—(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each group R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R₁₄ independently represents H or C_1-3 alkyl; and each group R₁₃ is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a5 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-6), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—(O(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m1)_p1—(O(C(R^a13)(R^a14)_p2—(O(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—(N(R_g11)(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—(C(O)NH—(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—C(O)NH—(C(R^a11)(R^a12))_m2—(O(C(R^a13)(R^a14))_m3)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(NHC(O)N—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13(R^a14)_m3)_p2—(O—(C(R^a15(R^a16)_m4)_p3—;

—(C(R^a9)(R^a10))_m1—C(O)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—C(S)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—S—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—C_6-10 arylene-(C(R^a13)(R^a14))_m3—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1-(4- to 15-membered heterocyclylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1-(5- to 15-membered heteroarylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C_3-15 cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(C_3-15cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—(C_3-15cycloalkylene-(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each R_g11 independently represents H or C_1-3 alkyl;
  • the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-6), L₂ represents the structure of the following formula:

• • —CH₂—O—CH₂—, —CH₂—O—(CH₂)₂—, —(CH₂)₁—O—(CH₂)₃—, —(CH₂)₁—O—(CH₂)₄—, —(CH₂)₁—O—(CH₂)₅—, —(CH₂)₁—O—(CH₂)₆—, —(CH₂)₁—O—(CH₂)₇—, —(CH₂)₁—O—(CH₂)₈—, —(CH₂)₁—O—(CH₂)₉—, —(CH₂)₁—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁—, —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—O—(CH₂)₄—, —(CH₂)₂—O—(CH₂)₅—, —(CH₂)₂—O—(CH₂)₆—, —(CH₂)₂—O—(CH₂)₇—, —(CH₂)₂—O—(CH₂)₈—, —(CH₂)₂—O—(CH₂)₉—, —(CH₂)₂—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁₁—, —(CH₂)₂—O—(CH₂)₁₂—, —(CH₂)₃—O—(CH₂)₁—, —(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—O—(CH₂)₃—, —(CH₂)₃—O—(CH₂)₄—, —(CH₂)₃—O—(CH₂)₅—, —(CH₂)₃—O—(CH₂)₆—, —(CH₂)₃—O—(CH₂)₇—, —(CH₂)₄—O—(CH₂)₁—, —(CH₂)₄—O—(CH₂)₂—, —(CH₂)₄—O—(CH₂)₃—, —(CH₂)₄—O—(CH₂)₄—, —(CH₂)₄—O—(CH₂)₅—, —(CH₂)₄—O—(CH₂)₆—, —(CH₂)₅—O—(CH₂)₁—, —(CH₂)₅—O—(CH₂)₂—, —(CH₂)₅—O—(CH₂)₃—, —(CH₂)₅—O—(CH₂)₄—, —(CH₂)₅—O—(CH₂)₅—, —(CH₂)₆—O—(CH₂)₁—, —(CH₂)₆—O—(CH₂)₂—, —(CH₂)₆—O—(CH₂)₃—, —(CH₂)₆—O—(CH₂)₄—, —(CH₂)₇—O—(CH₂)₁—, —(CH₂)₇—O—(CH₂)₂—, —(CH₂)₇—O—(CH₂)₃—, —(CH₂)₈—O—(CH₂)₁—, —(CH₂)₈—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₁—, —CH(CH₃)—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₃—, —CH(CH₃)—O—(CH₂)₄—, —CH(CH₃)—O—(CH₂)₅—, —CH(CH₃)—O—(CH₂)₆—, —CH(CH₃)—O—(CH₂)₇—, —CH(CH₃)—O—(CH₂)₈—, —CH(CH₃)—O—(CH₂)₉—, —CH(CH₃)—O—(CH₂)₁₀—, —CH₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₂)₆—, —CH₂—(O(CH₂)₂)₇—, —CH₂—(O(CH₂)₂)₈—, —CH₂—(O(CH₂)₂)₉—, —CH₂—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₂)₁—OCH₂—, —CH₂—(O(CH₂)₂)₂—OCH₂—, —CH₂—(O(CH₂)₂)₃—OCH₂—, —CH₂—(O(CH₂)₂)₄—OCH₂—, —CH₂—(O(CH₂)₂)₅—OCH₂—, —CH₂—(O(CH₂)₂)₆—OCH₂—, —CH₂—(O(CH₂)₂)₇—OCH₂—, —CH₂—(O(CH₂)₂)₈—OCH₂—, —CH₂—(O(CH₂)₂)₉—OCH₂—, —CH₂—(O(CH₂)₂)₁₀—OCH₂—, —(CH₂)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₂)₆—, —(CH₂)₂—(O(CH₂)₂)₇—, —(CH₂)₂—(O(CH₂)₂)₈—, —(CH₂)₂—(O(CH₂)₂)₉—, —(CH₂)₂—(O(CH₂)₂)₁₀—, —(CH₂)₃—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₂)₆—, —(CH₂)₃—(O(CH₂)₂)₇—, —(CH₂)₃—(O(CH₂)₂)₈—, —(CH₂)₃—(O(CH₂)₂)₉—, —(CH₂)₃—(O(CH₂)₂)₁₀—, —(CH₂)₄—(O(CH₂)₂)₂—, —(CH₂)₄—(O(CH₂)₂)₃—, —(CH₂)₄—(O(CH₂)₂)₄—, —(CH₂)₄—(O(CH₂)₂)₅—, —(CH₂)₄—(O(CH₂)₂)₆—, —(CH₂)₄—(O(CH₂)₂)₇—, —(CH₂)₄—(O(CH₂)₂)₈—, —(CH₂)₄—(O(CH₂)₂)₉—, —(CH₂)₄—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₃)₆—, —CH₂—(O(CH₂)₃)₇—, —CH₂—(O(CH₂)₃)₈—, —CH₂—(O(CH₂)₃)₉—, —CH₂—(O(CH₂)₃)₁₀—, —(CH₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₃)₆—, —(CH₂)₂—(O(CH₂)₃)₇—, —(CH₂)₂—(O(CH₂)₃)₈—, —(CH₂)₂—(O(CH₂)₃)₉—, —(CH₂)₂—(O(CH₂)₃)₁₀—, —(CH₂)₃—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₃)₆—, —(CH₂)₃—(O(CH₂)₃)₇—, —(CH₂)₃—(O(CH₂)₃)₈—, —(CH₂)₃—(O(CH₂)₃)₉—, —(CH₂)₃—(O(CH₂)₃)₁₀—, —CH₂—O—(CH₂)₂—O—(CH₂)₃—, —CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —CH₂—O—(CH₂)₃—O—(CH₂)₂—, —CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —CH₂—O—(CH₂)₂—O—CH₂—, —(CH₂)₂—O—(CH₂)₂O—CH₂—, —(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, —CH₂—C(O)—CH₂—, —CH₂—C(O)—(CH₂)₂—, —(CH₂)₁—C(O)—(CH₂)₃—, —(CH₂)₁—C(O)—(CH₂)₄—, —(CH₂)₁—C(O)—(CH₂)₅—, —(CH₂)₁—C(O)—(CH₂)₆—, —(CH₂)₁—C(O)—(CH₂)₇—, —(CH₂)₁—C(O)—(CH₂)₈—, —(CH₂)₁—C(O)—(CH₂)₉—, —(CH₂)₁—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁—, —(CH₂)₂—C(O)—(CH₂)₂—, —(CH₂)₂—C(O)—(CH₂)₃—, —(CH₂)₂—C(O)—(CH₂)₄—, —(CH₂)₂—C(O)—(CH₂)₅—, —(CH₂)₂—C(O)—(CH₂)₆—, —(CH₂)₂—C(O)—(CH₂)₇—, —(CH₂)₂—C(O)—(CH₂)₈—, —(CH₂)₂—C(O)—(CH₂)₉—, —(CH₂)₂—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁₁—, —(CH₂)₂—C(O)—(CH₂)₁₂—, —(CH₂)₃—C(O)—(CH₂)₁—, —(CH₂)₃—C(O)—(CH₂)₂—, —(CH₂)₃—C(O)—(CH₂)₃—, —(CH₂)₃—C(O)—(CH₂)₄—, —(CH₂)₃—C(O)—(CH₂)₅—, —(CH₂)₃—C(O)—(CH₂)₆—, —(CH₂)₃—C(O)—(CH₂)₇—, —(CH₂)₄—C(O)—(CH₂)₁—, —(CH₂)₄—C(O)—(CH₂)₂—, —(CH₂)₄—C(O)—(CH₂)₃—, —(CH₂)₄—C(O)—(CH₂)₄—, —(CH₂)₄—C(O)—(CH₂)₅—, —(CH₂)₄—C(O)—(CH₂)₆—, —(CH₂)₅—C(O)—(CH₂)₁—, —(CH₂)₅—C(O)—(CH₂)₂—, —(CH₂)₅—C(O)—(CH₂)₃—, —(CH₂)₅—C(O)—(CH₂)₄—, —(CH₂)₅—C(O)—(CH₂)₅—, —(CH₂)₆—C(O)—(CH₂)₁—, —(CH₂)₆—C(O)—(CH₂)₂—, —(CH₂)₆—C(O)—(CH₂)₃—, —(CH₂)₆—C(O)—(CH₂)₄—, —(CH₂)₇—C(O)—(CH₂)₁—, —(CH₂)₇—C(O)—(CH₂)₂—, —(CH₂)₇—C(O)—(CH₂)₃—, —(CH₂)₈—C(O)—(CH₂)₁—, —(CH₂)₈—C(O)—(CH₂)₂—, —CH₂—S—CH₂—, —CH₂—S—(CH₂)₂—, —(CH₂)₁—S—(CH₂)₃—, —(CH₂)₁—S—(CH₂)₄—, —(CH₂)₁—S—(CH₂)₅—, —(CH₂)₁—S—(CH₂)₆—, —(CH₂)₁—S—(CH₂)₇—, —(CH₂)₁—S—(CH₂)₈—, —(CH₂)₁—S—(CH₂)₉—, —(CH₂)₁—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁—, —(CH₂)₂—S—(CH₂)₂—, —(CH₂)₂—S—(CH₂)₃—, —(CH₂)₂—S—(CH₂)₄—, —(CH₂)₂—S—(CH₂)₅—, —(CH₂)₂—S—(CH₂)₆—, —(CH₂)₂—S—(CH₂)₇—, —(CH₂)₂—S—(CH₂)₈—, —(CH₂)₂—S—(CH₂)₉—, —(CH₂)₂—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁₁—, —(CH₂)₂—S—(CH₂)₁₂—, —(CH₂)₃—S—(CH₂)₁—, —(CH₂)₃—S—(CH₂)₂—, —(CH₂)₃—S—(CH₂)₃—, —(CH₂)₃—S—(CH₂)₄—, —(CH₂)₃—S—(CH₂)₅—, —(CH₂)₃—S—(CH₂)₆—, —(CH₂)₃—S—(CH₂)₇—, —(CH₂)₄—S—(CH₂)₁—, —(CH₂)₄—S—(CH₂)₂—, —(CH₂)₄—S—(CH₂)₃—, —(CH₂)₄—S—(CH₂)₄—, —(CH₂)₄—S—(CH₂)₅—, —(CH₂)₄—S—(CH₂)₆—, —(CH₂)₅—S—(CH₂)₁—, —(CH₂)₅—S—(CH₂)₂—, —(CH₂)₅—S—(CH₂)₃—, —(CH₂)₅—S—(CH₂)₄—, —(CH₂)₅—S—(CH₂)₅—, —(CH₂)₆—S—(CH₂)₁—, —(CH₂)₆—S—(CH₂)₂—, —(CH₂)₆—S—(CH₂)₃—, —(CH₂)₆—S—(CH₂)₄—, —(CH₂)₇—S—(CH₂)₁—, —(CH₂)₇—S—(CH₂)₂—, —(CH₂)₇—S—(CH₂)₃—, —(CH₂)₈—S—(CH₂)₁—, —(CH₂)₈—S—(CH₂)₂—, —CH₂—C(S)—CH₂—, —CH₂—C(S)—(CH₂)₂—, —(CH₂)₁—C(S)—(CH₂)₃—, —(CH₂)₁—C(S)—(CH₂)₄—, —(CH₂)₁—C(S)—(CH₂)₅—, —(CH₂)₁—C(S)—(CH₂)₆—, —(CH₂)₁—C(S)—(CH₂)₇—, —(CH₂)₁—C(S)—(CH₂)₈—, —(CH₂)₁—C(S)—(CH₂)₉—, —(CH₂)₁—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁—, —(CH₂)₂—C(S)—(CH₂)₂—, —(CH₂)₂—C(S)—(CH₂)₃—, —(CH₂)₂—C(S)—(CH₂)₄—, —(CH₂)₂—C(S)—(CH₂)₅—, —(CH₂)₂—C(S)—(CH₂)₆—, —(CH₂)₂—C(S)—(CH₂)₇—, —(CH₂)₂—C(S)—(CH₂)₈—, —(CH₂)₂—C(S)—(CH₂)₉—, —(CH₂)₂—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁₁—, —(CH₂)₂—C(S)—(CH₂)₁₂—, —(CH₂)₃—C(S)—(CH₂)₁—, —(CH₂)₃—C(S)—(CH₂)₂—, —(CH₂)₃—C(S)—(CH₂)₃—, —(CH₂)₃—C(S)—(CH₂)₄—, —(CH₂)₃—C(S)—(CH₂)₅—, —(CH₂)₃—C(S)—(CH₂)₆—, —(CH₂)₃—C(S)—(CH₂)₇—, —(CH₂)₄—C(S)—(CH₂)₁—, —(CH₂)₄—C(S)—(CH₂)₂—, —(CH₂)₄—C(S)—(CH₂)₃—, —(CH₂)₄—C(S)—(CH₂)₄—, —(CH₂)₄—C(S)—(CH₂)₅—, —(CH₂)₄—C(S)—(CH₂)₆—, —(CH₂)₅—C(S)—(CH₂)₁—, —(CH₂)₅—C(S)—(CH₂)₂—, —(CH₂)₅—C(S)—(CH₂)₃—, —(CH₂)₅—C(S)—(CH₂)₄—, —(CH₂)₅—C(S)—(CH₂)₅—, —(CH₂)₆—C(S)—(CH₂)₁—, —(CH₂)₆—C(S)—(CH₂)₂—, —(CH₂)₆—C(S)—(CH₂)₃—, —(CH₂)₆—C(S)—(CH₂)₄—, —(CH₂)₇—C(S)—(CH₂)₁—, —(CH₂)₇—C(S)—(CH₂)₂—, —(CH₂)₇—C(S)—(CH₂)₃—, —(CH₂)₈—C(S)—(CH₂)₁—, —(CH₂)₈—C(S)—(CH₂)₂—, —CH₂—C(O)O—CH₂—, —CH₂—C(O)O—(CH₂)₂—, —(CH₂)₁—C(O)O—(CH₂)₃—, —(CH₂)₁—C(O)O—(CH₂)₄—, —(CH₂)₁—C(O)O—(CH₂)₅—, —(CH₂)₁—C(O)O—(CH₂)₆—, —(CH₂)₁—C(O)O—(CH₂)₇—, —(CH₂)₁—C(O)O—(CH₂)₈—, —(CH₂)₁—C(O)O—(CH₂)₉—, —(CH₂)₁—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁—, —(CH₂)₂—C(O)O—(CH₂)₂—, —(CH₂)₂—C(O)O—(CH₂)₃—, —(CH₂)₂—C(O)O—(CH₂)₄—, —(CH₂)₂—C(O)O—(CH₂)₅—, —(CH₂)₂—C(O)O—(CH₂)₆—, —(CH₂)₂—C(O)O—(CH₂)₇—, —(CH₂)₂—C(O)O—(CH₂)₈—, —(CH₂)₂—C(O)O—(CH₂)₉—, —(CH₂)₂—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁₁—, —(CH₂)₂—C(O)O—(CH₂)₁₂—, —(CH₂)₃—C(O)O—(CH₂)₁—, —(CH₂)₃—C(O)O—(CH₂)₂—, —(CH₂)₃—C(O)O—(CH₂)₃—, —(CH₂)₃—C(O)O—(CH₂)₄—, —(CH₂)₃—C(O)O—(CH₂)₅—, —(CH₂)₃—C(O)O—(CH₂)₆—, —(CH₂)₃—C(O)O—(CH₂)₇—, —(CH₂)₄—C(O)O—(CH₂)₁—, —(CH₂)₄—C(O)O—(CH₂)₂—, —(CH₂)₄—C(O)O—(CH₂)₃—, —(CH₂)₄—C(O)O—(CH₂)₄—, —(CH₂)₄—C(O)O—(CH₂)₅—, —(CH₂)₄—C(O)O—(CH₂)₆—, —(CH₂)₅—C(O)O—(CH₂)₁—, —(CH₂)₅—C(O)O—(CH₂)₂—, —(CH₂)₅—C(O)O—(CH₂)₃—, —(CH₂)₅—C(O)O—(CH₂)₄—, —(CH₂)₅—C(O)O—(CH₂)₅—, —(CH₂)₆—C(O)O—(CH₂)₁—, —(CH₂)₆—C(O)O—(CH₂)₂—, —(CH₂)₆—C(O)O—(CH₂)₃—, —(CH₂)₆—C(O)O—(CH₂)₄—, —(CH₂)₇—C(O)O—(CH₂)₁—, —(CH₂)₇—C(O)O—(CH₂)₂—, —(CH₂)₇—C(O)O—(CH₂)₃—, —(CH₂)₈—C(O)O—(CH₂)₁—, —(CH₂)₈—C(O)O—(CH₂)₂—, —CH₂—OC(O)—CH₂—, —CH₂—OC(O)—(CH₂)₂—, —(CH₂)₁—OC(O)—(CH₂)₃—, —(CH₂)₁—OC(O)—(CH₂)₄—, —(CH₂)₁—OC(O)—(CH₂)₅—, —(CH₂)₁—OC(O)—(CH₂)₆—, —(CH₂)₁—OC(O)—(CH₂)₇—, —(CH₂)₁—OC(O)—(CH₂)₈—, —(CH₂)₁—OC(O)—(CH₂)₉—, —(CH₂)₁—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁—, —(CH₂)₂—OC(O)—(CH₂)₂—, —(CH₂)₂—OC(O)—(CH₂)₃—, —(CH₂)₂—OC(O)—(CH₂)₄—, —(CH₂)₂—OC(O)—(CH₂)₅—, —(CH₂)₂—OC(O)—(CH₂)₆—, —(CH₂)₂—OC(O)—(CH₂)₇—, —(CH₂)₂—OC(O)—(CH₂)₈—, —(CH₂)₂—OC(O)—(CH₂)₉—, —(CH₂)₂—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁₁—, —(CH₂)₂—OC(O)—(CH₂)₁₂—, —(CH₂)₃—OC(O)—(CH₂)₁—, —(CH₂)₃—OC(O)—(CH₂)₂—, —(CH₂)₃—OC(O)—(CH₂)₃—, —(CH₂)₃—OC(O)—(CH₂)₄—, —(CH₂)₃—OC(O)—(CH₂)₅—, —(CH₂)₃—OC(O)—(CH₂)₆—, —(CH₂)₃—OC(O)—(CH₂)₇—, —(CH₂)₄—OC(O)—(CH₂)₁—, —(CH₂)₄—OC(O)—(CH₂)₂—, —(CH₂)₄—OC(O)—(CH₂)₃—, —(CH₂)₄—OC(O)—(CH₂)₄—, —(CH₂)₄—OC(O)—(CH₂)₅—, —(CH₂)₄—OC(O)—(CH₂)₆—, —(CH₂)₅—OC(O)—(CH₂)₁—, —(CH₂)₅—OC(O)—(CH₂)₂—, —(CH₂)₅—OC(O)—(CH₂)₃—, —(CH₂)₅—OC(O)—(CH₂)₄—, —(CH₂)₅—OC(O)—(CH₂)₅—, —(CH₂)₆—OC(O)—(CH₂)₁—, —(CH₂)₆—OC(O)—(CH₂)₂—, —(CH₂)₆—OC(O)—(CH₂)₃—, —(CH₂)₆—OC(O)—(CH₂)₄—, —(CH₂)₇—OC(O)—(CH₂)₁—, —(CH₂)₇—OC(O)—(CH₂)₂—, —(CH₂)₇—OC(O)—(CH₂)₃—, —(CH₂)₈—OC(O)—(CH₂)₁—, —(CH₂)₈—OC(O)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₁—, —(CH₂)₁—N(R_g11)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₃—, —(CH₂)₁—N(R_g11)—(CH₂)₄—, —(CH₂)₁—N(R_g11)—(CH₂)₅—, —(CH₂)₁—N(R_g11)—(CH₂)₆—, —(CH₂)₁—N(R_g11)—(CH₂)₇—, —(CH₂)₁—N(R_g11)—(CH₂)₈—, —(CH₂)₁—N(R_g11)—(CH₂)₉—, —(CH₂)₁—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₂—, —(CH₂)₂—N(R_g11)—(CH₂)₃—, —(CH₂)₂—N(R_g11)—(CH₂)₄—, —(CH₂)₂—N(R_g11)—(CH₂)₅—, —(CH₂)₂—N(R_g11)—(CH₂)₆—, —(CH₂)₂—N(R_g11)—(CH₂)₇—, —(CH₂)₂—N(R_g11)—(CH₂)₈—, —(CH₂)₂—N(R_g11)—(CH₂)₉—, —(CH₂)₂—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)_n—, —(CH₂)₂—N(R_g11)—(CH₂)₁₂—, —(CH₂)₃—N(R_g11)—(CH₂)₁—, —(CH₂)₃—N(R_g11)—(CH₂)₂—, —(CH₂)₃—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₁—, —(CH₂)₄—N(R_g11)—(CH₂)₂—, —(CH₂)₄—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₁—, —(CH₂)₅—N(R_g11)—(CH₂)₂—, —(CH₂)₅—N(R_g11)—(CH₂)₃—, —(CH₂)₅—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₅—, —(CH₂)₆—N(R_g11)—(CH₂)₁—, —(CH₂)₆—N(R_g11)—(CH₂)₂—, —(CH₂)₆—N(R_g11)—(CH₂)₃—, —(CH₂)₇—N(R_g11)—(CH₂)₁—, —(CH₂)₇—N(R_g11)—(CH₂)₂—, —(CH₂)₇—N(R_g11)—(CH₂)₃—, —(CH₂)₈—N(R_g11)—(CH₂)₁—, —(CH₂)₈—N(R_g11)—(CH₂)₂—, —(CH₂)₈—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₁—, —CH(CH₃)—N(R_g11)—(CH₂)₂—, —CH(CH₃)—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₄—, —CH(CH₃)—N(R_g11)—(CH₂)₅—, —CH(CH₃)—N(R_g11)—(CH₂)₆—, —CH(CH₃)—N(R_g11)—(CH₂)₇—, —CH(CH₃)—N(R_g11)—(CH₂)₈—, —CH(CH₃)—N(R_g11)—(CH₂)₉—, —CH(CH₃)—N(R_g11)—(CH₂)₁₀—, —CH₂C(O)NHCH₂—, —(CH₂)₂C(O)NH(CH₂)₂—, —(CH₂)₂C(O)NH(CH₂)₃—, —(CH₂)₂C(O)NH(CH₂)₄—, —(CH₂)₂C(O)NH(CH₂)₅—, —(CH₂)₃C(O)NH(CH₂)₃—, —(CH₂)₃C(O)NH(CH₂)₄—, —(CH₂)₄C(O)NH(CH₂)₄—, —(CH₂)₅C(O)NH(CH₂)₅—, —(CH₂)₆C(O)NH(CH₂)₇—, —(CH₂)₆C(O)NH(CH₂)₆—, —(CH₂)₇C(O)NH(CH₂)₇—, —(CH₂)₈C(O)NH(CH₂)₈, —(CH₂)₉C(O)NH(CH₂)₉—, —(CH₂)₁₀C(O)NH(CH₂)₁₀—, —(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, —CH₂NHC(O)CH₂—, —(CH₂)₂NHC(O)(CH₂)₂—, —(CH₂)₂NHC(O)(CH₂)₃—, —(CH₂)₂NHC(O)(CH₂)₄—, —(CH₂)₂NHC(O)(CH₂)₅—, —(CH₂)₃NHC(O)(CH₂)₃—, —(CH₂)₃NHC(O)(CH₂)₄—, —(CH₂)₄NHC(O)(CH₂)₄—, —(CH₂)₅NHC(O)(CH₂)₅—, —(CH₂)₈NHC(O)(CH₂)₇—, —(CH₂)₆NHC(O)(CH₂)₆—, —(CH₂)₇NHC(O)(CH₂)₇—, —(CH₂)₈NHC(O)(CH₂)₈, —(CH₂)₉NHC(O)(CH₂)₉—, —(CH₂)₁₀NHC(O)(CH₂)₁₀—, —(CH₂)₄NHC(O)(CH₂)₈—, —(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, —(CH₂)₄NHC(O)CH₂—, —CH₂-piperidinylene-CH₂—, —CH₂-piperidinylene-(CH₂)₂—, —CH₂-piperidinylene-(CH₂)₃—, —CH₂-piperidinylene-(CH₂)₄—, —CH₂-piperidinylene-(CH₂)₅—, —CH₂-piperidinylene-(CH₂)₆—, —CH₂-piperidinylene-(CH₂)₇—, —CH₂-piperidinylene-(CH₂)₈—, —(CH₂)₂-piperidinylene-(CH₂)₁—, —(CH₂)₂-piperidinylene-(CH₂)₂—, —(CH₂)₂-piperidinylene-(CH₂)₃—, —(CH₂)₂-piperidinylene-(CH₂)₄—, —(CH₂)₂-piperidinylene-(CH₂)₅—, —(CH₂)₂-piperidinylene-(CH₂)₆—, —(CH₂)₂-piperidinylene-(CH₂)₇—, —(CH₂)₂-piperidinylene-(CH₂)₈—, —(CH₂)₃-piperidinylene-CH₂—, —(CH₂)₃-piperidinylene-(CH₂)₂—, —(CH₂)₃-piperidinylene-(CH₂)₃—, —(CH₂)₃-piperidinylene-(CH₂)₄—, —(CH₂)₃-piperidinylene-(CH₂)₅—, —(CH₂)₃-piperidinylene-(CH₂)₆—, —(CH₂)₃-piperidinylene-(CH₂)₇—, —(CH₂)₃-piperidinylene-(CH₂)₈—, —(CH₂)₄-piperidinylene-CH₂—, —(CH₂)₄-piperidinylene-(CH₂)₂—, —(CH₂)₄-piperidinylene-(CH₂)₃—, —(CH₂)₄-piperidinylene-(CH₂)₄—, —(CH₂)₄-piperidinylene-(CH₂)₅—, —(CH₂)₄-piperidinylene-(CH₂)₆—, —(CH₂)₄-piperidinylene-(CH₂)₇—, —(CH₂)₄-piperidinylene-(CH₂)₈—, —(CH₂)₅-piperidinylene-(CH₂)₁—, —(CH₂)₅-piperidinylene-(CH₂)₂—, —(CH₂)₅-piperidinylene-(CH₂)₃—, —(CH₂)₅-piperidinylene-(CH₂)₄—, —(CH₂)₅-piperidinylene-(CH₂)₅—, —(CH₂)₅-piperidinylene-(CH₂)₆—, —(CH₂)₅-piperidinylene-(CH₂)₇—, —(CH₂)₅-piperidinylene-(CH₂)₈—, —(CH₂)₆-piperidinylene-(CH₂)₁—, —(CH₂)₆-piperidinylene-(CH₂)₂—, —(CH₂)₆-piperidinylene-(CH₂)₃—, —(CH₂)₆-piperidinylene-(CH₂)₄—, —(CH₂)₆-piperidinylene-(CH₂)₅—, —(CH₂)₆-piperidinylene-(CH₂)₆—, —(CH₂)₆-piperidinylene-(CH₂)₇—, —(CH₂)₆-piperidinylene-(CH₂)₈—, —(CH₂)₇-piperidinylene-(CH₂)₁—, —(CH₂)₇-piperidinylene-(CH₂)₂—, —(CH₂)₇-piperidinylene-(CH₂)₃—, —(CH₂)₇-piperidinylene-(CH₂)₄—, —(CH₂)₇-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-CH₂—, —(CH₂)₈-piperidinylene-(CH₂)₂—, —(CH₂)₈-piperidinylene-(CH₂)₃—, —(CH₂)₈-piperidinylene-(CH₂)₄—, —(CH₂)₈-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-(CH₂)₆—, —(CH₂)₈-piperidinylene-(CH₂)₇—, —(CH₂)₈-piperidinylene-(CH₂)₈—, —CH₂-piperazinylene-CH₂—, —CH₂-piperazinylene-(CH₂)₂—, —CH₂-piperazinylene-(CH₂)₃—, —CH₂-piperazinylene-(CH₂)₄—, —CH₂-piperazinylene-(CH₂)₅—, —CH₂-piperazinylene-(CH₂)₆—, —CH₂-piperazinylene-(CH₂)₇—, —CH₂-piperazinylene-(CH₂)₈—, —(CH₂)₂-piperazinylene-(CH₂)₁—, —(CH₂)₂-piperazinylene-(CH₂)₂—, —(CH₂)₂-piperazinylene-(CH₂)₃—, —(CH₂)₂-piperazinylene-(CH₂)₄—, —(CH₂)₂-piperazinylene-(CH₂)₅—, —(CH₂)₂-piperazinylene-(CH₂)₆—, —(CH₂)₂-piperazinylene-(CH₂)₇—, —(CH₂)₂-piperazinylene-(CH₂)₈—, —(CH₂)₃-piperazinylene-CH₂—, —(CH₂)₃-piperazinylene-(CH₂)₂—, —(CH₂)₃-piperazinylene-(CH₂)₃—, —(CH₂)₃-piperazinylene-(CH₂)₄—, —(CH₂)₃-piperazinylene-(CH₂)₅—, —(CH₂)₃-piperazinylene-(CH₂)₆—, —(CH₂)₃-piperazinylene-(CH₂)₇—, —(CH₂)₃-piperazinylene-(CH₂)₈—, —(CH₂)₄-piperazinylene-CH₂—, —(CH₂)₄-piperazinylene-(CH₂)₂—, —(CH₂)₄-piperazinylene-(CH₂)₃—, —(CH₂)₄-piperazinylene-(CH₂)₄—, —(CH₂)₄-piperazinylene-(CH₂)₅—, —(CH₂)₄-piperazinylene-(CH₂)₆—, —(CH₂)₄-piperazinylene-(CH₂)₇—, —(CH₂)₄-piperazinylene-(CH₂)₈—, —(CH₂)₅-piperazinylene-(CH₂)₁—, —(CH₂)₅-piperazinylene-(CH₂)₂—, —(CH₂)₅-piperazinylene-(CH₂)₃—, —(CH₂)₅-piperazinylene-(CH₂)₄—, —(CH₂)₅-piperazinylene-(CH₂)₅—, —(CH₂)₅-piperazinylene-(CH₂)₆—, —(CH₂)₅-piperazinylene-(CH₂)₇—, —(CH₂)₅-piperazinylene-(CH₂)₈—, —(CH₂)₆-piperazinylene-(CH₂)₁—, —(CH₂)₆-piperazinylene-(CH₂)₂—, —(CH₂)₆-piperazinylene-(CH₂)₃—, —(CH₂)₆-piperazinylene-(CH₂)₄—, —(CH₂)₆-piperazinylene-(CH₂)₅—, —(CH₂)₆-piperazinylene-(CH₂)₆—, —(CH₂)₆-piperazinylene-(CH₂)₇—, —(CH₂)₆-piperazinylene-(CH₂)₈—, —(CH₂)₇-piperazinylene-(CH₂)₁—, —(CH₂)₇-piperazinylene-(CH₂)₂—, —(CH₂)₇-piperazinylene-(CH₂)₃—, —(CH₂)₇-piperazinylene-(CH₂)₄—, —(CH₂)₇-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-CH₂—, —(CH₂)₈-piperazinylene-(CH₂)₂—, —(CH₂)₈-piperazinylene-(CH₂)₃—, —(CH₂)₈-piperazinylene-(CH₂)₄—, —(CH₂)₈-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-(CH₂)₆—, —(CH₂)₈-piperazinylene-(CH₂)₇—, —(CH₂)₈-piperazinylene-(CH₂)₈—, —CH₂-propylene-CH₂—, —CH₂-propylene-(CH₂)₂—, —CH₂-propylene-(CH₂)₃—, —CH₂-propylene-(CH₂)₄—, —CH₂-propylene-(CH₂)₅—, —CH₂-propylene-(CH₂)₆—, —CH₂-propylene-(CH₂)₇—, —CH₂-propylene-(CH₂)₈—, —(CH₂)₂-propylene-(CH₂)₁—, —(CH₂)₂-propylene-(CH₂)₂—, —(CH₂)₂-propylene-(CH₂)₃—, —(CH₂)₂-propylene-(CH₂)₄—, —(CH₂)₂-propylene-(CH₂)₅—, —(CH₂)₂-propylene-(CH₂)₆—, —(CH₂)₂-propylene-(CH₂)₇—, —(CH₂)₂-propylene-(CH₂)₈—, —(CH₂)₃-propylene-CH₂—, —(CH₂)₃-propylene-(CH₂)₂—, —(CH₂)₃-propylene-(CH₂)₃—, —(CH₂)₃-propylene-(CH₂)₄—, —(CH₂)₃-propylene-(CH₂)₅—, —(CH₂)₃-propylene-(CH₂)₆—, —(CH₂)₃-propylene-(CH₂)₇—, —(CH₂)₃-propylene-(CH₂)₈—, —(CH₂)₄-propylene-CH₂—, —(CH₂)₄-propylene-(CH₂)₂—, —(CH₂)₄-propylene-(CH₂)₃—, —(CH₂)₄-propylene-(CH₂)₄—, —(CH₂)₄-propylene-(CH₂)₅—, —(CH₂)₄-propylene-(CH₂)₆—, —(CH₂)₄-propylene-(CH₂)₇—, —(CH₂)₄-propylene-(CH₂)₈—, —(CH₂)₅-propylene-(CH₂)₁—, —(CH₂)₅-propylene-(CH₂)₂—, —(CH₂)₅-propylene-(CH₂)₃—, —(CH₂)₅-propylene-(CH₂)₄—, —(CH₂)₅-propylene-(CH₂)₅—, —(CH₂)₅-propylene-(CH₂)₆—, —(CH₂)₅-propylene-(CH₂)₇—, —(CH₂)₅-propylene-(CH₂)₈—, —(CH₂)₆-propylene-(CH₂)₁—, —(CH₂)₆-propylene-(CH₂)₂—, —(CH₂)₆-propylene-(CH₂)₃—, —(CH₂)₆-propylene-(CH₂)₄—, —(CH₂)₆-propylene-(CH₂)₅—, —(CH₂)₆-propylene-(CH₂)₆—, —(CH₂)₆-propylene-(CH₂)₇—, —(CH₂)₆-propylene-(CH₂)₈—, —(CH₂)₇-propylene-(CH₂)₁—, —(CH₂)₇-propylene-(CH₂)₂—, —(CH₂)₇-propylene-(CH₂)₃—, —(CH₂)₇-propylene-(CH₂)₄—, —(CH₂)₇-propylene-(CH₂)₈—, —(CH₂)₈-propylene-CH₂—, —(CH₂)₈-propylene-(CH₂)₂—, —(CH₂)₈-propylene-(CH₂)₃—, —(CH₂)₈-propylene-(CH₂)₄—, —(CH₂)₈-propylene-(CH₂)₅—, —(CH₂)₈-propylene-(CH₂)₆—, —(CH₂)₈-propylene-(CH₂)₇—, —(CH₂)₈-propylene-(CH₂)₈—, —CH₂-diazacycloheptanylene-CH₂—, —CH₂-diazacycloheptanylene-(CH₂)₂—, —CH₂-diazacycloheptanylene-(CH₂)₃—, —CH₂-diazacycloheptanylene-(CH₂)₄—, —CH₂-diazacycloheptanylene-(CH₂)₅—, —CH₂-diazacycloheptanylene-(CH₂)₆—, —CH₂-diazacycloheptanylene-(CH₂)₇—, —CH₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₃-diazacycloheptanylene-CH₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₄-diazacycloheptanylene-CH₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-CH₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.2.1]octylene-CH₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.2]octylene-CH₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₈—;
  • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof; and
  • each R_g11 independently represents H or C_1-3 alkyl.

In some embodiments of the compound of Formula (I-6), L₂ represents the structure of the following formula:

In some embodiments of the compound of Formula (I-6), R_b1 represents:

• • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and the C_3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-6), R_b1 represents:

In some embodiments, the compound of Formula (I) is also of Formula (I-7):

• • wherein R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_b, (R_1a)_n, R_a, R_1a and n are as defined in the compound of Formula (I) above and the embodiments thereof;
  • wherein R_a represents the following formula:

R_a2—X₃—,

• • wherein X₃ represents N(R₁₁), C(O)O, OC(O), C(O)NH, NHC(O), O, S, optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene or optionally substituted C_3-15cycloalkylene), optionally substituted arylene (e.g., optionally substituted C_6-10 arylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene) or optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 5- to 15-membered heterocyclylene), wherein R₁₁ represents H or C_1-3 alkyl, and
  • R_a2 represents optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 4- to 15-membered heterocyclyl), optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl) or optionally substituted aryl (e.g., optionally substituted C_6-10 aryl);
  • and
  • R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkyl, C₁-C₂₉ alkyl, C₁-C₂₈ alkyl, C₁-C₂₇ alkyl, C₁-C₂₆ alkyl, C₁-C₂₅ alkyl, C₁-C₂₄ alkyl, C₁-C₂₃ alkyl, C₁-C₂₂ alkyl, C₁-C₂₁ alkyl, C₁-C₂₀ alkyl, C₁-C₁₉ alkyl, C₁-C₁₈ alkyl, C₁-C₁₇ alkyl, C₁-C₁₆ alkyl, C₁-C₁₅ alkyl, C₁-C₁₄ alkyl, C₁-C₁₃ alkyl, C₁-C₁₂ alkyl, C₁-C₁₁ alkyl, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₈ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, or C₁-C₂ alkyl) optionally substituted with D or halogen, or
  • R_b represents the following formula:

R_b1—X₄-L₂-,

• • • wherein L₂ represents:
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene), or
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of cycloalkylene (e.g., C_3-20cycloalkylene or C_3-15cycloalkylene)), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, or 4- to 15-membered heterocyclylene), arylene (e.g., C_3-15 arylene or C_6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene, arylene and the heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), cyano or any combination thereof;
    • X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted cycloalkylene (e.g., optionally substituted C_3-20cycloalkylene, or optionally substituted C_3-15cycloalkylene), optionally substituted arylene (e.g., optionally substituted C_6-20 arylene, or optionally substituted C_6-10 arylene), optionally substituted heterocyclylene (e.g., optionally substituted 4- to 20-membered heterocyclylene, or optionally substituted 4- to 15-membered heterocyclylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), triazolylene-NH—, or —NH— triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, or X₄ represents a bond; and
    • R_b1 represents (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl, or optionally substituted C_6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 4- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl).

In some embodiments of the compound of Formula (I-7), R_a represents the following formula:

R_a2—X₃—,

• • wherein X₃ represents N(R₁₁), C(O)O, OC(O), C(O)NH, NHC(O), O, S, optionally substituted C_3-20cycloalkylene, optionally substituted C_6-20aryl, optionally substituted 5- to 20-membered heteroaryl or optionally substituted 4- to 20-membered heterocyclylene, wherein R₁₁ represents H or C_1-3 alkyl, and wherein the C_3-20cycloalkylene and the 4- to 20-membered heterocyclylene are each independently optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), oxo, or any combination thereof, and the C_6-20 aryl and the 5- to 20-membered heteroaryl are each independently optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), or any combination thereof, and
  • R_a2 represents optionally substituted C_3-20cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted 5- to 20-membered heteroaryl or optionally substituted C_6-20 aryl, wherein the C_3-20cycloalkyl, the C_6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-7), R_a2 represents:

• • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-7), R_a2—X₃— represents:

In some embodiments of the compound of Formula (I-7), R_b represents C_1-60 alkyl (e.g., C₁-C₃₀ alkyl, C₁-C₂₉ alkyl, C₁-C₂₈ alkyl, C₁-C₂₇ alkyl, C₁-C₂₆ alkyl, C₁-C₂₅ alkyl, C₁-C₂₄ alkyl, C₁-C₂₃ alkyl, C₁-C₂₂ alkyl, C₁-C₂₁ alkyl, C₁-C₂₀ alkyl, C₁-C₁₉ alkyl, C₁-C₁₈ alkyl, C₁-C₁₇ alkyl, C₁-C₁₆ alkyl, C₁-C₁₅ alkyl, C₁-C₁₄ alkyl, C₁-C₁₃ alkyl, C₁-C₁₂ alkyl, C₁-C₁₁ alkyl, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₈ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, or C₁-C₂ alkyl) optionally substituted with D or halogen.

In some embodiments of the compound of Formula (I-7), R_b represents the following group: CH₃, CF₃, CD₃, CH₂CH₃, —(CH₂)₂—CH₃, —(CH₂)₃—CH₃, —(CH₂)₄—CH₃, —(CH₂)₅—CH₃, —(CH₂)₆—CH₃, —(CH₂)₇—CH₃, —(CH₂)₈—CH₃, —(CH₂)₉—CH₃, —(CH₂)₁₀—CH₃, —(CH₂)₁₁—CH₃, —(CH₂)₁₂—CH₃, —(CH₂)₁₃—CH₃, —(CH₂)₁₄—CH₃, —(CH₂)₁₅—CH₃, —(CH₂)₁₆—CH₃, —(CH₂)₁₇—CH₃, —(CH₂)₁₈—CH₃, —(CH₂)₁₉—CH₃, —(CH₂)₂₀—CH₃, —(CH₂)₂₁—CH₃, —(CH₂)₂₂—CH₃, —(CH₂)₂₃—CH₃, —(CH₂)₂₄—CH₃, —(CH₂)₂₅—CH₃, —(CH₂)₂₆—CH₃, —(CH₂)₂₇—CH₃, —(CH₂)₂₈—CH₃, or —(CH₂)₂₉—CH₃.

In some embodiments of the compound of Formula (I-7), R_b can represents the following formula:

R_b1—X₄-L₂-,

• • wherein L₂ represents:
    • linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof, or
    • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₃ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₂ and R₁₃ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₂, R₁₃, or a combination of R₁₂ and R₁₃; wherein each R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₄ independently represents H or C_1-3 alkyl, and in case that two or more groups R₁₂ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₂ are not directly connected to each other; and wherein each R₁₃ is independently selected from the group consisting of C_3-15cycloalkylene, 4- to 15-membered heterocyclylene, C_6-10 arylene, 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene, C_6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and the linear or branched C_2-60 alkylene is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof;
  • X₄ represents a bond, or X₄ represents N(R₁₅), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, OS(O)₂, optionally substituted C_3-20cycloalkylene, optionally substituted C_6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R₁₅ represents H or C_1-3 alkyl, and the C_3-20cycloalkylene, the C_6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, halogen, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; and
  • R_b1 represents optionally substituted C_3-20cycloalkyl, optionally substituted C_6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C_3-20cycloalkyl, the C_6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof.

In some embodiments of the compound of Formula (I-7), L₂ represents the structure of the following formula: —C_2-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (1-7), L₂ represents the following group:

• • —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₂—CF₂—(CH₂)₂—, —(CH₂)₆—, —(CH₂)₇—, —(CH₂)₈—, —(CH₂)₉—, —(CH₂)₁₀—, —(CH₂)₁₁—, —(CH₂)₁₂—, —(CH₂)₁₃—, —(CH₂)₁₄—, —(CH₂)₁₅—, —(CH₂)₁₆—, —(CH₂)₁₇—, —(CH₂)₁₈—, —(CH₂)₁₉—, —(CH₂)₂₀—, —(CH₂)₂₁—, —(CH₂)₂₂—, —(CH₂)₂₅—, or —(CH₂)₃₀—;
  • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ of the group is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (I-7), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—(R₁₂(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—(R₁₃(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₂—R₁₃—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₂(C(R^a11)(R^a12))_m2)_p1—(R₁₃(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₃—R₁₂—(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(R₁₃(C(R^a11)(R^a12))_m2)_p1—(R₁₂(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each group R₁₂ is independently selected from the group consisting of O, S, N(R₁₄), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R₁₄ independently represents H or C_1-3 alkyl; and each group R₁₃ is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl (e.g., C_1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), C_3-6cycloalkyl (e.g., cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl) or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-7), L₂ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—(O(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m1)_p1—(O(C(R^a13)(R^a14)_p2—(O(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—(N(R_g11)(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—(C(O)NH—(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—C(O)NH—(C(R^a11)(R^a12))_m2—(O(C(R^a13)(R^a14))_m3)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(NHC(O)N—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13(R^a14)_m3)_p2—(O—(C(R^a15(R^a16)_m4)_p3—;

—(C(R^a9)(R^a10))_m1—C(O)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—C(S)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—S—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—C_6-10 arylene-(C(R^a13)(R^a14))_m3—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1-(4- to 15-membered heterocyclylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1-(5- to 15-membered heteroarylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C_3-15 cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(C_3-15cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—(C_3-15cycloalkylene-(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each R_g1 independently represents H or C_1-3 alkyl;
  • the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-7), L₂ represents the structure of the following formula:

• • —CH₂—O—CH₂—, —CH₂—O—(CH₂)₂—, —(CH₂)₁—O—(CH₂)₃—, —(CH₂)₁—O—(CH₂)₄—, —(CH₂)₁—O—(CH₂)₅—, —(CH₂)₁—O—(CH₂)₆—, —(CH₂)₁—O—(CH₂)₇—, —(CH₂)₁—O—(CH₂)₈—, —(CH₂)₁—O—(CH₂)₉—, —(CH₂)₁—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁—, —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—O—(CH₂)₄—, —(CH₂)₂—O—(CH₂)₅—, —(CH₂)₂—O—(CH₂)₆—, —(CH₂)₂—O—(CH₂)₇—, —(CH₂)₂—O—(CH₂)₈—, —(CH₂)₂—O—(CH₂)₉—, —(CH₂)₂—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁₁—, —(CH₂)₂—O—(CH₂)₁₂—, —(CH₂)₃—O—(CH₂)₁—, —(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—O—(CH₂)₃—, —(CH₂)₃—O—(CH₂)₄—, —(CH₂)₃—O—(CH₂)₅—, —(CH₂)₃—O—(CH₂)₆—, —(CH₂)₃—O—(CH₂)₇—, —(CH₂)₄—O—(CH₂)₁—, —(CH₂)₄—O—(CH₂)₂—, —(CH₂)₄—O—(CH₂)₃—, —(CH₂)₄—O—(CH₂)₄—, —(CH₂)₄—O—(CH₂)₅—, —(CH₂)₄—O—(CH₂)₆—, —(CH₂)₅—O—(CH₂)₁—, —(CH₂)₅—O—(CH₂)₂—, —(CH₂)₅—O—(CH₂)₃—, —(CH₂)₅—O—(CH₂)₄—, —(CH₂)₅—O—(CH₂)₅—, —(CH₂)₆—O—(CH₂)₁—, —(CH₂)₆—O—(CH₂)₂—, —(CH₂)₆—O—(CH₂)₃—, —(CH₂)₆—O—(CH₂)₄—, —(CH₂)₇—O—(CH₂)₁—, —(CH₂)₇—O—(CH₂)₂—, —(CH₂)₇—O—(CH₂)₃—, —(CH₂)₈—O—(CH₂)₁—, —(CH₂)₈—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₁—, —CH(CH₃)—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₃—, —CH(CH₃)—O—(CH₂)₄—, —CH(CH₃)—O—(CH₂)₅—, —CH(CH₃)—O—(CH₂)₆—, —CH(CH₃)—O—(CH₂)₇—, —CH(CH₃)—O—(CH₂)₈—, —CH(CH₃)—O—(CH₂)₉—, —CH(CH₃)—O—(CH₂)₁₀—, —CH₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₂)₆—, —CH₂—(O(CH₂)₂)₇—, —CH₂—(O(CH₂)₂)₈—, —CH₂—(O(CH₂)₂)₉—, —CH₂—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₂)₁—OCH₂—, —CH₂—(O(CH₂)₂)₂—OCH₂—, —CH₂—(O(CH₂)₂)₃—OCH₂—, —CH₂—(O(CH₂)₂)₄—OCH₂—, —CH₂—(O(CH₂)₂)₅—OCH₂—, —CH₂—(O(CH₂)₂)₆—OCH₂—, —CH₂—(O(CH₂)₂)₇—OCH₂—, —CH₂—(O(CH₂)₂)₈—OCH₂—, —CH₂—(O(CH₂)₂)₉—OCH₂—, —CH₂—(O(CH₂)₂)₁₀—OCH₂—, —(CH₂)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₂)₆—, —(CH₂)₂—(O(CH₂)₂)₇—, —(CH₂)₂—(O(CH₂)₂)₈—, —(CH₂)₂—(O(CH₂)₂)₉—, —(CH₂)₂—(O(CH₂)₂)₁₀—, —(CH₂)₃—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₂)₆—, —(CH₂)₃—(O(CH₂)₂)₇—, —(CH₂)₃—(O(CH₂)₂)₈—, —(CH₂)₃—(O(CH₂)₂)₉—, —(CH₂)₃—(O(CH₂)₂)₁₀—, —(CH₂)₄—(O(CH₂)₂)₂—, —(CH₂)₄—(O(CH₂)₂)₃—, —(CH₂)₄—(O(CH₂)₂)₄—, —(CH₂)₄—(O(CH₂)₂)₅—, —(CH₂)₄—(O(CH₂)₂)₆—, —(CH₂)₄—(O(CH₂)₂)₇—, —(CH₂)₄—(O(CH₂)₂)₈—, —(CH₂)₄—(O(CH₂)₂)₉—, —(CH₂)₄—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₃)₆—, —CH₂—(O(CH₂)₃)₇—, —CH₂—(O(CH₂)₃)₈—, —CH₂—(O(CH₂)₃)₉—, —CH₂—(O(CH₂)₃)₁₀—, —(CH₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₃)₆—, —(CH₂)₂—(O(CH₂)₃)₇—, —(CH₂)₂—(O(CH₂)₃)₈—, —(CH₂)₂—(O(CH₂)₃)₉—, —(CH₂)₂—(O(CH₂)₃)₁₀—, —(CH₂)₃—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₃)₆—, —(CH₂)₃—(O(CH₂)₃)₇—, —(CH₂)₃—(O(CH₂)₃)₈—, —(CH₂)₃—(O(CH₂)₃)₉—, —(CH₂)₃—(O(CH₂)₃)₁₀—, —CH₂—O—(CH₂)₂—O—(CH₂)₃—, —CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —CH₂—O—(CH₂)₃—O—(CH₂)₂—, —CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —CH₂—O—(CH₂)₂—O—CH₂—, —(CH₂)₂—O—(CH₂)₂O—CH₂—, —(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, —CH₂—C(O)—CH₂—, —CH₂—C(O)—(CH₂)₂—, —(CH₂)₁—C(O)—(CH₂)₃—, —(CH₂)₁—C(O)—(CH₂)₄—, —(CH₂)₁—C(O)—(CH₂)₅—, —(CH₂)₁—C(O)—(CH₂)₆—, —(CH₂)₁—C(O)—(CH₂)₇—, —(CH₂)₁—C(O)—(CH₂)₈—, —(CH₂)₁—C(O)—(CH₂)₉—, —(CH₂)₁—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁—, —(CH₂)₂—C(O)—(CH₂)₂—, —(CH₂)₂—C(O)—(CH₂)₃—, —(CH₂)₂—C(O)—(CH₂)₄—, —(CH₂)₂—C(O)—(CH₂)₅—, —(CH₂)₂—C(O)—(CH₂)₆—, —(CH₂)₂—C(O)—(CH₂)₇—, —(CH₂)₂—C(O)—(CH₂)₈—, —(CH₂)₂—C(O)—(CH₂)₉—, —(CH₂)₂—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁₁—, —(CH₂)₂—C(O)—(CH₂)₁₂—, —(CH₂)₃—C(O)—(CH₂)₁—, —(CH₂)₃—C(O)—(CH₂)₂—, —(CH₂)₃—C(O)—(CH₂)₃—, —(CH₂)₃—C(O)—(CH₂)₄—, —(CH₂)₃—C(O)—(CH₂)₅—, —(CH₂)₃—C(O)—(CH₂)₆—, —(CH₂)₃—C(O)—(CH₂)₇—, —(CH₂)₄—C(O)—(CH₂)₁—, —(CH₂)₄—C(O)—(CH₂)₂—, —(CH₂)₄—C(O)—(CH₂)₃—, —(CH₂)₄—C(O)—(CH₂)₄—, —(CH₂)₄—C(O)—(CH₂)₅—, —(CH₂)₄—C(O)—(CH₂)₆—, —(CH₂)₅—C(O)—(CH₂)₁—, —(CH₂)₅—C(O)—(CH₂)₂—, —(CH₂)₅—C(O)—(CH₂)₃—, —(CH₂)₅—C(O)—(CH₂)₄—, —(CH₂)₅—C(O)—(CH₂)₅—, —(CH₂)₆—C(O)—(CH₂)₁—, —(CH₂)₆—C(O)—(CH₂)₂—, —(CH₂)₆—C(O)—(CH₂)₃—, —(CH₂)₆—C(O)—(CH₂)₄—, —(CH₂)₇—C(O)—(CH₂)₁—, —(CH₂)₇—C(O)—(CH₂)₂—, —(CH₂)₇—C(O)—(CH₂)₃—, —(CH₂)₈—C(O)—(CH₂)₁—, —(CH₂)₈—C(O)—(CH₂)₂—, —CH₂—S—CH₂—, —CH₂—S—(CH₂)₂—, —(CH₂)₁—S—(CH₂)₃—, —(CH₂)₁—S—(CH₂)₄—, —(CH₂)₁—S—(CH₂)₅—, —(CH₂)₁—S—(CH₂)₆—, —(CH₂)₁—S—(CH₂)₇—, —(CH₂)₁—S—(CH₂)₈—, —(CH₂)₁—S—(CH₂)₉—, —(CH₂)₁—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁—, —(CH₂)₂—S—(CH₂)₂—, —(CH₂)₂—S—(CH₂)₃—, —(CH₂)₂—S—(CH₂)₄—, —(CH₂)₂—S—(CH₂)₅—, —(CH₂)₂—S—(CH₂)₆—, —(CH₂)₂—S—(CH₂)₇—, —(CH₂)₂—S—(CH₂)₈—, —(CH₂)₂—S—(CH₂)₉—, —(CH₂)₂—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁₁—, —(CH₂)₂—S—(CH₂)₁₂—, —(CH₂)₃—S—(CH₂)₁—, —(CH₂)₃—S—(CH₂)₂—, —(CH₂)₃—S—(CH₂)₃—, —(CH₂)₃—S—(CH₂)₄—, —(CH₂)₃—S—(CH₂)₅—, —(CH₂)₃—S—(CH₂)₆—, —(CH₂)₃—S—(CH₂)₇—, —(CH₂)₄—S—(CH₂)₁—, —(CH₂)₄—S—(CH₂)₂—, —(CH₂)₄—S—(CH₂)₃—, —(CH₂)₄—S—(CH₂)₄—, —(CH₂)₄—S—(CH₂)₅—, —(CH₂)₄—S—(CH₂)₆—, —(CH₂)₅—S—(CH₂)₁—, —(CH₂)₅—S—(CH₂)₂—, —(CH₂)₅—S—(CH₂)₃—, —(CH₂)₅—S—(CH₂)₄—, —(CH₂)₅—S—(CH₂)₅—, —(CH₂)₆—S—(CH₂)₁—, —(CH₂)₆—S—(CH₂)₂—, —(CH₂)₆—S—(CH₂)₃—, —(CH₂)₆—S—(CH₂)₄—, —(CH₂)₇—S—(CH₂)₁—, —(CH₂)₇—S—(CH₂)₂—, —(CH₂)₇—S—(CH₂)₃—, —(CH₂)₈—S—(CH₂)₁—, —(CH₂)₈—S—(CH₂)₂—, —CH₂—C(S)—CH₂—, —CH₂—C(S)—(CH₂)₂—, —(CH₂)₁—C(S)—(CH₂)₃—, —(CH₂)₁—C(S)—(CH₂)₄—, —(CH₂)₁—C(S)—(CH₂)₅—, —(CH₂)₁—C(S)—(CH₂)₆—, —(CH₂)₁—C(S)—(CH₂)₇—, —(CH₂)₁—C(S)—(CH₂)₈—, —(CH₂)₁—C(S)—(CH₂)₉—, —(CH₂)₁—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁—, —(CH₂)₂—C(S)—(CH₂)₂—, —(CH₂)₂—C(S)—(CH₂)₃—, —(CH₂)₂—C(S)—(CH₂)₄—, —(CH₂)₂—C(S)—(CH₂)₅—, —(CH₂)₂—C(S)—(CH₂)₆—, —(CH₂)₂—C(S)—(CH₂)₇—, —(CH₂)₂—C(S)—(CH₂)₈—, —(CH₂)₂—C(S)—(CH₂)₉—, —(CH₂)₂—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁₁—, —(CH₂)₂—C(S)—(CH₂)₁₂—, —(CH₂)₃—C(S)—(CH₂)₁—, —(CH₂)₃—C(S)—(CH₂)₂—, —(CH₂)₃—C(S)—(CH₂)₃—, —(CH₂)₃—C(S)—(CH₂)₄—, —(CH₂)₃—C(S)—(CH₂)₅—, —(CH₂)₃—C(S)—(CH₂)₆—, —(CH₂)₃—C(S)—(CH₂)₇—, —(CH₂)₄—C(S)—(CH₂)₁—, —(CH₂)₄—C(S)—(CH₂)₂—, —(CH₂)₄—C(S)—(CH₂)₃—, —(CH₂)₄—C(S)—(CH₂)₄—, —(CH₂)₄—C(S)—(CH₂)₅—, —(CH₂)₄—C(S)—(CH₂)₆—, —(CH₂)₅—C(S)—(CH₂)₁—, —(CH₂)₅—C(S)—(CH₂)₂—, —(CH₂)₅—C(S)—(CH₂)₃—, —(CH₂)₅—C(S)—(CH₂)₄—, —(CH₂)₅—C(S)—(CH₂)₅—, —(CH₂)₆—C(S)—(CH₂)₁—, —(CH₂)₆—C(S)—(CH₂)₂—, —(CH₂)₆—C(S)—(CH₂)₃—, —(CH₂)₆—C(S)—(CH₂)₄—, —(CH₂)₇—C(S)—(CH₂)₁—, —(CH₂)₇—C(S)—(CH₂)₂—, —(CH₂)₇—C(S)—(CH₂)₃—, —(CH₂)₈—C(S)—(CH₂)₁—, —(CH₂)₈—C(S)—(CH₂)₂—, —CH₂—C(O)O—CH₂—, —CH₂—C(O)O—(CH₂)₂—, —(CH₂)₁—C(O)O—(CH₂)₃—, —(CH₂)₁—C(O)O—(CH₂)₄—, —(CH₂)₁—C(O)O—(CH₂)₅—, —(CH₂)₁—C(O)O—(CH₂)₆—, —(CH₂)₁—C(O)O—(CH₂)₇—, —(CH₂)₁—C(O)O—(CH₂)₈—, —(CH₂)₁—C(O)O—(CH₂)₉—, —(CH₂)₁—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁—, —(CH₂)₂—C(O)O—(CH₂)₂—, —(CH₂)₂—C(O)O—(CH₂)₃—, —(CH₂)₂—C(O)O—(CH₂)₄—, —(CH₂)₂—C(O)O—(CH₂)₅—, —(CH₂)₂—C(O)O—(CH₂)₆—, —(CH₂)₂—C(O)O—(CH₂)₇—, —(CH₂)₂—C(O)O—(CH₂)₈—, —(CH₂)₂—C(O)O—(CH₂)₉—, —(CH₂)₂—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁₁—, —(CH₂)₂—C(O)O—(CH₂)₁₂—, —(CH₂)₃—C(O)O—(CH₂)₁—, —(CH₂)₃—C(O)O—(CH₂)₂—, —(CH₂)₃—C(O)O—(CH₂)₃—, —(CH₂)₃—C(O)O—(CH₂)₄—, —(CH₂)₃—C(O)O—(CH₂)₅—, —(CH₂)₃—C(O)O—(CH₂)₆—, —(CH₂)₃—C(O)O—(CH₂)₇—, —(CH₂)₄—C(O)O—(CH₂)₁—, —(CH₂)₄—C(O)O—(CH₂)₂—, —(CH₂)₄—C(O)O—(CH₂)₃—, —(CH₂)₄—C(O)O—(CH₂)₄—, —(CH₂)₄—C(O)O—(CH₂)₅—, —(CH₂)₄—C(O)O—(CH₂)₆—, —(CH₂)₅—C(O)O—(CH₂)₁—, —(CH₂)₅—C(O)O—(CH₂)₂—, —(CH₂)₅—C(O)O—(CH₂)₃—, —(CH₂)₅—C(O)O—(CH₂)₄—, —(CH₂)₅—C(O)O—(CH₂)₅—, —(CH₂)₆—C(O)O—(CH₂)₁—, —(CH₂)₆—C(O)O—(CH₂)₂—, —(CH₂)₆—C(O)O—(CH₂)₃—, —(CH₂)₆—C(O)O—(CH₂)₄—, —(CH₂)₇—C(O)O—(CH₂)₁—, —(CH₂)₇—C(O)O—(CH₂)₂—, —(CH₂)₇—C(O)O—(CH₂)₃—, —(CH₂)₈—C(O)O—(CH₂)₁—, —(CH₂)₈—C(O)O—(CH₂)₂—, —CH₂—OC(O)—CH₂—, —CH₂—OC(O)—(CH₂)₂—, —(CH₂)₁—OC(O)—(CH₂)₃—, —(CH₂)₁—OC(O)—(CH₂)₄—, —(CH₂)₁—OC(O)—(CH₂)₅—, —(CH₂)₁—OC(O)—(CH₂)₆—, —(CH₂)₁—OC(O)—(CH₂)₇—, —(CH₂)₁—OC(O)—(CH₂)₈—, —(CH₂)₁—OC(O)—(CH₂)₉—, —(CH₂)₁—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁—, —(CH₂)₂—OC(O)—(CH₂)₂—, —(CH₂)₂—OC(O)—(CH₂)₃—, —(CH₂)₂—OC(O)—(CH₂)₄—, —(CH₂)₂—OC(O)—(CH₂)₅—, —(CH₂)₂—OC(O)—(CH₂)₆—, —(CH₂)₂—OC(O)—(CH₂)₇—, —(CH₂)₂—OC(O)—(CH₂)₈—, —(CH₂)₂—OC(O)—(CH₂)₉—, —(CH₂)₂—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁₁—, —(CH₂)₂—OC(O)—(CH₂)₁₂—, —(CH₂)₃—OC(O)—(CH₂)₁—, —(CH₂)₃—OC(O)—(CH₂)₂—, —(CH₂)₃—OC(O)—(CH₂)₃—, —(CH₂)₃—OC(O)—(CH₂)₄—, —(CH₂)₃—OC(O)—(CH₂)₅—, —(CH₂)₃—OC(O)—(CH₂)₆—, —(CH₂)₃—OC(O)—(CH₂)₇—, —(CH₂)₄—OC(O)—(CH₂)₁—, —(CH₂)₄—OC(O)—(CH₂)₂—, —(CH₂)₄—OC(O)—(CH₂)₃—, —(CH₂)₄—OC(O)—(CH₂)₄—, —(CH₂)₄—OC(O)—(CH₂)₅—, —(CH₂)₄—OC(O)—(CH₂)₆—, —(CH₂)₅—OC(O)—(CH₂)₁—, —(CH₂)₅—OC(O)—(CH₂)₂—, —(CH₂)₅—OC(O)—(CH₂)₃—, —(CH₂)₅—OC(O)—(CH₂)₄—, —(CH₂)₅—OC(O)—(CH₂)₅—, —(CH₂)₆—OC(O)—(CH₂)₁—, —(CH₂)₆—OC(O)—(CH₂)₂—, —(CH₂)₆—OC(O)—(CH₂)₃—, —(CH₂)₆—OC(O)—(CH₂)₄—, —(CH₂)₇—OC(O)—(CH₂)₁—, —(CH₂)₇—OC(O)—(CH₂)₂—, —(CH₂)₇—OC(O)—(CH₂)₃—, —(CH₂)₈—OC(O)—(CH₂)₁—, —(CH₂)₈—OC(O)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₁—, —(CH₂)₁—N(R_g11)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₃—, —(CH₂)₁—N(R_g11)—(CH₂)₄—, —(CH₂)₁—N(R_g11)—(CH₂)₅—, —(CH₂)₁—N(R_g11)—(CH₂)₆—, —(CH₂)₁—N(R_g11)—(CH₂)₇—, —(CH₂)₁—N(R_g11)—(CH₂)₈—, —(CH₂)₁—N(R_g11)—(CH₂)₉—, —(CH₂)₁—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₂—, —(CH₂)₂—N(R_g11)—(CH₂)₃—, —(CH₂)₂—N(R_g11)—(CH₂)₄—, —(CH₂)₂—N(R_g11)—(CH₂)₅—, —(CH₂)₂—N(R_g11)—(CH₂)₆—, —(CH₂)₂—N(R_g11)—(CH₂)₇—, —(CH₂)₂—N(R_g11)—(CH₂)₈—, —(CH₂)₂—N(R_g11)—(CH₂)₉—, —(CH₂)₂—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₁₂—, —(CH₂)₃—N(R_g11)—(CH₂)₁—, —(CH₂)₃—N(R_g11)—(CH₂)₂—, —(CH₂)₃—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₁—, —(CH₂)₄—N(R_g11)—(CH₂)₂—, —(CH₂)₄—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₁—, —(CH₂)₅—N(R_g11)—(CH₂)₂—, —(CH₂)₅—N(R_g11)—(CH₂)₃—, —(CH₂)₅—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₅—, —(CH₂)₆—N(R_g11)—(CH₂)₁—, —(CH₂)₆—N(R_g11)—(CH₂)₂—, —(CH₂)₆—N(R_g11)—(CH₂)₃—, —(CH₂)₇—N(R_g11)—(CH₂)₁—, —(CH₂)₇—N(R_g11)—(CH₂)₂—, —(CH₂)₇—N(R_g11)—(CH₂)₃—, —(CH₂)₈—N(R_g11)—(CH₂)₁—, —(CH₂)₈—N(R_g11)—(CH₂)₂—, —(CH₂)₈—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₁—, —CH(CH₃)—N(R_g11)—(CH₂)₂—, —CH(CH₃)—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₄—, —CH(CH₃)—N(R_g11)—(CH₂)₅—, —CH(CH₃)—N(R_g11)—(CH₂)₆—, —CH(CH₃)—N(R_g11)—(CH₂)₇—, —CH(CH₃)—N(R_g11)—(CH₂)₈—, —CH(CH₃)—N(R_g11)—(CH₂)₉—, —CH(CH₃)—N(R_g11)—(CH₂)₁₀—, —CH₂C(O)NHCH₂—, —(CH₂)₂C(O)NH(CH₂)₂—, —(CH₂)₂C(O)NH(CH₂)₃—, —(CH₂)₂C(O)NH(CH₂)₄—, —(CH₂)₂C(O)NH(CH₂)₅—, —(CH₂)₃C(O)NH(CH₂)₃—, —(CH₂)₃C(O)NH(CH₂)₄—, —(CH₂)₄C(O)NH(CH₂)₄—, —(CH₂)₅C(O)NH(CH₂)₅—, —(CH₂)₆C(O)NH(CH₂)₇—, —(CH₂)₆C(O)NH(CH₂)₆—, —(CH₂)₇C(O)NH(CH₂)₇—, —(CH₂)₈C(O)NH(CH₂)₈—, —(CH₂)₉C(O)NH(CH₂)₉—, —(CH₂)₁₀C(O)NH(CH₂)₁₀—, —(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, —CH₂NHC(O)CH₂—, —(CH₂)₂NHC(O)(CH₂)₂—, —(CH₂)₂NHC(O)(CH₂)₃—, —(CH₂)₂NHC(O)(CH₂)₄—, —(CH₂)₂NHC(O)(CH₂)₅—, —(CH₂)₃NHC(O)(CH₂)₃—, —(CH₂)₃NHC(O)(CH₂)₄—, —(CH₂)₄NHC(O)(CH₂)₄—, —(CH₂)₅NHC(O)(CH₂)₅—, —(CH₂)₆NHC(O)(CH₂)₇—, —(CH₂)₆NHC(O)(CH₂)₆—, —(CH₂)₇NHC(O)(CH₂)₇—, —(CH₂)₈NHC(O)(CH₂)₈, —(CH₂)₉NHC(O)(CH₂)₉—, —(CH₂)₁₀NHC(O)(CH₂)₁₀—, —(CH₂)₄NHC(O)(CH₂)₈—, —(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, —(CH₂)₄NHC(O)CH₂—, —CH₂-piperidinylene-CH₂—, —CH₂-piperidinylene-(CH₂)₂—, —CH₂-piperidinylene-(CH₂)₃—, —CH₂-piperidinylene-(CH₂)₄—, —CH₂-piperidinylene-(CH₂)₅—, —CH₂-piperidinylene-(CH₂)₆—, —CH₂-piperidinylene-(CH₂)₇—, —CH₂-piperidinylene-(CH₂)₈—, —(CH₂)₂-piperidinylene-(CH₂)₁—, —(CH₂)₂-piperidinylene-(CH₂)₂—, —(CH₂)₂-piperidinylene-(CH₂)₃—, —(CH₂)₂-piperidinylene-(CH₂)₄—, —(CH₂)₂-piperidinylene-(CH₂)₅—, —(CH₂)₂-piperidinylene-(CH₂)₆—, —(CH₂)₂-piperidinylene-(CH₂)₇—, —(CH₂)₂-piperidinylene-(CH₂)₈—, —(CH₂)₃-piperidinylene-CH₂—, —(CH₂)₃-piperidinylene-(CH₂)₂—, —(CH₂)₃-piperidinylene-(CH₂)₃—, —(CH₂)₃-piperidinylene-(CH₂)₄—, —(CH₂)₃-piperidinylene-(CH₂)₅—, —(CH₂)₃-piperidinylene-(CH₂)₆—, —(CH₂)₃-piperidinylene-(CH₂)₇—, —(CH₂)₃-piperidinylene-(CH₂)₈—, —(CH₂)₄-piperidinylene-CH₂—, —(CH₂)₄-piperidinylene-(CH₂)₂—, —(CH₂)₄-piperidinylene-(CH₂)₃—, —(CH₂)₄-piperidinylene-(CH₂)₄—, —(CH₂)₄-piperidinylene-(CH₂)₅—, —(CH₂)₄-piperidinylene-(CH₂)₆—, —(CH₂)₄-piperidinylene-(CH₂)₇—, —(CH₂)₄-piperidinylene-(CH₂)₈—, —(CH₂)₅-piperidinylene-(CH₂)₁—, —(CH₂)₈-piperidinylene-(CH₂)₂—, —(CH₂)₅-piperidinylene-(CH₂)₃—, —(CH₂)₅-piperidinylene-(CH₂)₄—, —(CH₂)₅-piperidinylene-(CH₂)₅—, —(CH₂)₅-piperidinylene-(CH₂)₆—, —(CH₂)₅-piperidinylene-(CH₂)₇—, —(CH₂)₅-piperidinylene-(CH₂)₈—, —(CH₂)₆-piperidinylene-(CH₂)₁—, —(CH₂)₆-piperidinylene-(CH₂)₂—, —(CH₂)₆-piperidinylene-(CH₂)₃—, —(CH₂)₆-piperidinylene-(CH₂)₄—, —(CH₂)₆-piperidinylene-(CH₂)₅—, —(CH₂)₆-piperidinylene-(CH₂)₆—, —(CH₂)₆-piperidinylene-(CH₂)₇—, —(CH₂)₆-piperidinylene-(CH₂)₈—, —(CH₂)₇-piperidinylene-(CH₂)₁—, —(CH₂)₇-piperidinylene-(CH₂)₂—, —(CH₂)₇-piperidinylene-(CH₂)₃—, —(CH₂)₇-piperidinylene-(CH₂)₄—, —(CH₂)₇-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-CH₂—, —(CH₂)₈-piperidinylene-(CH₂)₂—, —(CH₂)₈-piperidinylene-(CH₂)₃—, —(CH₂)₈-piperidinylene-(CH₂)₄—, —(CH₂)₈-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-(CH₂)₆—, —(CH₂)₈-piperidinylene-(CH₂)₇—, —(CH₂)₈-piperidinylene-(CH₂)₈—, —CH₂-piperazinylene-CH₂—, —CH₂-piperazinylene-(CH₂)₂—, —CH₂-piperazinylene-(CH₂)₃—, —CH₂-piperazinylene-(CH₂)₄—, —CH₂-piperazinylene-(CH₂)₅—, —CH₂-piperazinylene-(CH₂)₆—, —CH₂-piperazinylene-(CH₂)₇—, —CH₂-piperazinylene-(CH₂)₈—, —(CH₂)₂-piperazinylene-(CH₂)₁—, —(CH₂)₂-piperazinylene-(CH₂)₂—, —(CH₂)₂-piperazinylene-(CH₂)₃—, —(CH₂)₂-piperazinylene-(CH₂)₄—, —(CH₂)₂-piperazinylene-(CH₂)₅—, —(CH₂)₂-piperazinylene-(CH₂)₆—, —(CH₂)₂-piperazinylene-(CH₂)₇—, —(CH₂)₂-piperazinylene-(CH₂)₈—, —(CH₂)₃-piperazinylene-CH₂—, —(CH₂)₃-piperazinylene-(CH₂)₂—, —(CH₂)₃-piperazinylene-(CH₂)₃—, —(CH₂)₃-piperazinylene-(CH₂)₄—, —(CH₂)₃-piperazinylene-(CH₂)₅—, —(CH₂)₃-piperazinylene-(CH₂)₆—, —(CH₂)₃-piperazinylene-(CH₂)₇—, —(CH₂)₃-piperazinylene-(CH₂)₈—, —(CH₂)₄-piperazinylene-CH₂—, —(CH₂)₄-piperazinylene-(CH₂)₂—, —(CH₂)₄-piperazinylene-(CH₂)₃—, —(CH₂)₄-piperazinylene-(CH₂)₄—, —(CH₂)₄-piperazinylene-(CH₂)₅—, —(CH₂)₄-piperazinylene-(CH₂)₆—, —(CH₂)₄-piperazinylene-(CH₂)₇—, —(CH₂)₄-piperazinylene-(CH₂)₈—, —(CH₂)₅-piperazinylene-(CH₂)₁—, —(CH₂)₅-piperazinylene-(CH₂)₂—, —(CH₂)₅-piperazinylene-(CH₂)₃—, —(CH₂)₅-piperazinylene-(CH₂)₄—, —(CH₂)₅-piperazinylene-(CH₂)₅—, —(CH₂)₅-piperazinylene-(CH₂)₆—, —(CH₂)₅-piperazinylene-(CH₂)₇—, —(CH₂)₅-piperazinylene-(CH₂)₈—, —(CH₂)₆-piperazinylene-(CH₂)₁—, —(CH₂)₆-piperazinylene-(CH₂)₂—, —(CH₂)₆-piperazinylene-(CH₂)₃—, —(CH₂)₆-piperazinylene-(CH₂)₄—, —(CH₂)₆-piperazinylene-(CH₂)₅—, —(CH₂)₆-piperazinylene-(CH₂)₆—, —(CH₂)₆-piperazinylene-(CH₂)₇—, —(CH₂)₆-piperazinylene-(CH₂)₈—, —(CH₂)₇-piperazinylene-(CH₂)₁—, —(CH₂)₇-piperazinylene-(CH₂)₂—, —(CH₂)₇-piperazinylene-(CH₂)₃—, —(CH₂)₇-piperazinylene-(CH₂)₄—, —(CH₂)₇-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-CH₂—, —(CH₂)₈-piperazinylene-(CH₂)₂—, —(CH₂)₈-piperazinylene-(CH₂)₃—, —(CH₂)₈-piperazinylene-(CH₂)₄—, —(CH₂)₈-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-(CH₂)₆—, —(CH₂)₈-piperazinylene-(CH₂)₇—, —(CH₂)₈-piperazinylene-(CH₂)₈—, —CH₂-propylene-CH₂—, —CH₂-propylene-(CH₂)₂—, —CH₂-propylene-(CH₂)₃—, —CH₂-propylene-(CH₂)₄—, —CH₂-propylene-(CH₂)₅—, —CH₂-propylene-(CH₂)₆—, —CH₂-propylene-(CH₂)₇—, —CH₂-propylene-(CH₂)₈—, —(CH₂)₂-propylene-(CH₂)₁—, —(CH₂)₂-propylene-(CH₂)₂—, —(CH₂)₂-propylene-(CH₂)₃—, —(CH₂)₂-propylene-(CH₂)₄—, —(CH₂)₂-propylene-(CH₂)₅—, —(CH₂)₂-propylene-(CH₂)₆—, —(CH₂)₂-propylene-(CH₂)₇—, —(CH₂)₂-propylene-(CH₂)₈—, —(CH₂)₃-propylene-CH₂—, —(CH₂)₃-propylene-(CH₂)₂—, —(CH₂)₃-propylene-(CH₂)₃—, —(CH₂)₃-propylene-(CH₂)₄—, —(CH₂)₃-propylene-(CH₂)₅—, —(CH₂)₃-propylene-(CH₂)₆—, —(CH₂)₃-propylene-(CH₂)₇—, —(CH₂)₃-propylene-(CH₂)₈—, —(CH₂)₄-propylene-CH₂—, —(CH₂)₄-propylene-(CH₂)₂—, —(CH₂)₄-propylene-(CH₂)₃—, —(CH₂)₄-propylene-(CH₂)₄—, —(CH₂)₄-propylene-(CH₂)₅—, —(CH₂)₄-propylene-(CH₂)₆—, —(CH₂)₄-propylene-(CH₂)₇—, —(CH₂)₄-propylene-(CH₂)₈—, —(CH₂)₅-propylene-(CH₂)₁—, —(CH₂)₅-propylene-(CH₂)₂—, —(CH₂)₅-propylene-(CH₂)₃—, —(CH₂)₅-propylene-(CH₂)₄—, —(CH₂)₅-propylene-(CH₂)₅—, —(CH₂)₅-propylene-(CH₂)₆—, —(CH₂)₅-propylene-(CH₂)₇—, —(CH₂)₅-propylene-(CH₂)₈—, —(CH₂)₆-propylene-(CH₂)₁—, —(CH₂)₆-propylene-(CH₂)₂—, —(CH₂)₆-propylene-(CH₂)₃—, —(CH₂)₆-propylene-(CH₂)₄—, —(CH₂)₆-propylene-(CH₂)₅—, —(CH₂)₆-propylene-(CH₂)₆—, —(CH₂)₆-propylene-(CH₂)₇—, —(CH₂)₆-propylene-(CH₂)₈—, —(CH₂)₇-propylene-(CH₂)₁—, —(CH₂)₇-propylene-(CH₂)₂—, —(CH₂)₇-propylene-(CH₂)₃—, —(CH₂)₇-propylene-(CH₂)₄—, —(CH₂)₇-propylene-(CH₂)₈—, —(CH₂)₈-propylene-CH₂—, —(CH₂)₈-propylene-(CH₂)₂—, —(CH₂)₈-propylene-(CH₂)₃—, —(CH₂)₈-propylene-(CH₂)₄—, —(CH₂)₈-propylene-(CH₂)₅—, —(CH₂)₈-propylene-(CH₂)₆—, —(CH₂)₈-propylene-(CH₂)₇—, —(CH₂)₈-propylene-(CH₂)₈—, —CH₂-diazacycloheptanylene-CH₂—, —CH₂-diazacycloheptanylene-(CH₂)₂—, —CH₂-diazacycloheptanylene-(CH₂)₃—, —CH₂-diazacycloheptanylene-(CH₂)₄—, —CH₂-diazacycloheptanylene-(CH₂)₅—, —CH₂-diazacycloheptanylene-(CH₂)₆—, —CH₂-diazacycloheptanylene-(CH₂)₇—, —CH₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₃-diazacycloheptanylene-CH₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₄-diazacycloheptanylene-CH₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-CH₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.2.1]octylene-CH₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.2]octylene-CH₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₈—;
  • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof; and
  • each R_g11 independently represents H or C_1-3 alkyl.

In some embodiments of the compound of Formula (I-7), L₂ represents the structure of the following formula:

In some embodiments of the compound of Formula (I-7), R_b1 represents:

• • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-7), R_b1 represents:

In some embodiments, the compound of Formula (I) is also of Formula (I-8):

• • wherein R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_b, (R_1a)_n, R_a, R_1a and n are as defined in the compound of Formula (I) above and the embodiments thereof;
  • wherein R_a represents halogen or cyano, and
  • R_b represents the following formula:

R_b2—X₅-L₃-,

• • • wherein L₃ represents:
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene), or
      • optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₆ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₇ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₆ and R₁₇ inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₆, R₁₇ or a combination of R₁₆ and R₁₇; wherein each R₁₆ is independently selected from the group consisting of O, S, N(R₁₈), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(═S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₈ represents H or C_1-3 alkyl, and in case that two or more groups R₁₆ are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group, the two or more groups R₁₆ are not directly connected to each other; and wherein each R₁₇ is independently selected from the group consisting of cycloalkylene (e.g., C_3-20cycloalkylene, or C_3-15cycloalkylene), heterocyclylene e.g., 4- to 20-membered heterocyclylene, or 5- to 15-membered heterocyclylene), arylene (e.g., C_6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenylene (e.g., C_2-6 alkenylene), alkynylene (e.g., C_2-6 alkynylene) or any combination thereof, wherein the cycloalkylene, the heterocyclylene, arylene and the heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, cyano or any combination thereof;
    • X₅ represents N(R₁₉), C(O)O, OC(O), C(O)NH, NHC(O), C(O), 0, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, or OS(O)₂, wherein R₁₉ represents H or C_1-3 alkyl, or X₅ represents a bond; and
    • R_b2 represents optionally substituted cycloalkyl (e.g., optionally substituted C_3-20cycloalkyl, or optionally substituted C_3-15cycloalkyl), optionally substituted aryl (e.g., optionally substituted C_6-20 aryl, or optionally substituted C_6-10 aryl), optionally substituted heterocyclyl (e.g., optionally substituted 4- to 20-membered heterocyclyl, or optionally substituted 4- to 15-membered heterocyclyl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl), or R_b2 represents the following formula:

• • • • wherein R_f1, R_f2, R_f3, R_f4 and R_fs are as defined in the compound of Formula (I) or Formula (I-2) above and their embodiments.

In some embodiments of the compound of Formula (I-8), R_a represents halogen.

In some embodiments of the compound of Formula (I-8), R_a represents cyano.

In some embodiments of the compound of Formula (I-8), R_a represents cyano.

In some embodiments of the compound of Formula (I-8), R_b represents the following formula:

R_b2—X₅-L₃-,

• • wherein L₃ represents:
    • linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene)
    • optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof, or optionally substituted linear or branched C_2-60 alkylene (e.g., C₂-C₄₀ alkylene, C₂-C₃₀ alkylene, C₂-C₂₉ alkylene, C₂-C₂₈ alkylene, C₂-C₂₇ alkylene, C₂-C₂₆ alkylene, C₂-C₂₅ alkylene, C₂-C₂₄ alkylene, C₂-C₂₃ alkylene, C₂-C₂₂ alkylene, C₂-C₂₁ alkylene, C₂-C₂₀ alkylene, C₂-C₁₉ alkylene, C₂-C₁₈ alkylene, C₂-C₁₇ alkylene, C₂-C₁₆ alkylene, C₂-C₁₅ alkylene, C₂-C₁₄ alkylene, C₂-C₁₃ alkylene, C₂-C₁₂ alkylene, C₂-C₁₁ alkylene, C₂-C₁₀ alkylene, C₂-C₉ alkylene, C₂-C₈ alkylene, C₂-C₇ alkylene, C₂-C₆ alkylene, C₂-C₅ alkylene, C₂-C₄ alkylene, C₂-C₃ alkylene, or ethylene) with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₆ and/or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₇ and/or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R₁₆ and R₁₇ inserted into its backbone carbon chain; wherein carbon-carbon bond between one or more pairs (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 pair) of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R₁₆, R₁₇, or a combination of R₁₆ and R₁₇; wherein each R₁₆ is independently selected from the group consisting of O, S, N(R₁₈), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein R₁₈ represents H or C_1-3 alkyl, and in case that two or more groups R₁₆ are inserted into the backbone carbon chain of the linear or branched C₂-60 alkylene group, the two or more groups R₁₆ are not directly connected to each other; and wherein each R₁₇ is independently selected from the group consisting of C_3-15cycloalkylene, 4- to 15-membered heterocyclylene, C_6-10 arylene, 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the 4- to 15-membered heterocyclylene, C_6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂- and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and the linear or branched C_2-60 alkylene is optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof;
  • X₅ represents N(R₁₉), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)₂, S(O)₂NH, NHS(O)₂, S(O)₂O, or OS(O)₂, wherein R₁₉ represents H or C_1-3 alkyl, or X₅ represents a bond; and
  • R_b2 represents optionally substituted C_3-20cycloalkyl, optionally substituted C_6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C_3-20cycloalkyl, the C_6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—), or any combination thereof; or
  • R_b2 represents the following formula:

• • • wherein R_f1, R_f2, R_f3, R_f4 and R_f5 are as defined in the compound of Formula (I) or Formula (I-2) above and their embodiments.

In some embodiments of the compound of Formula (I-8), L₃ represents the structure of the following formula: —C_2-30 alkylene-, wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ groups of the C_2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (I-8), L₃ represents the following group:

• • —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₂—CF₂—(CH₂)₂—, —(CH₂)₆—, —(CH₂)₇—, —(CH₂)₈—, —(CH₂)₉—, —(CH₂)₁₀—, —(CH₂)₁₁—, —(CH₂)₁₂—, —(CH₂)₁₃—, —(CH₂)₁₄—, —(CH₂)₁₅—, —(CH₂)₁₆—, —(CH₂)₁₇—, —(CH₂)₁₈—, —(CH₂)₁₉—, —(CH₂)₂₀—, —(CH₂)₂₁—, —(CH₂)₂₂—, —(CH₂)₂₅—, or —(CH₂)₃₀—;
  • wherein a hydrogen atom of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) CH₂ of the group is optionally replaced with a substituent selected from the group consisting of: D, C_1-4 alkyl, halogen, C_3-6cycloalkyl or any combination thereof.

In some embodiments of the compound of Formula (I-8), L₃ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(R₁₆(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₆(C(R^a11)(R^a12))_m2)_p1—(R₁₆(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₇(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₇(C(R^a11)(R^a12))_m2)_p1—(R₁₇(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₇(C(R^a11)(R^a12))_m2)_p1—(R₁₇(C(R^a13)(R^a14))_m3)_p2—(R₁₇(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(R₁₆—R₁₇—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(R₁₆(C(R^a11)(R^a12))_m2)_p1—(R₁₇(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(R₁₇—R₁₆—(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(R₁₇(C(R^a11)(R^a12))_m2)_p1—(R₁₆(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each group R₁₆ is independently selected from the group consisting of O, S, N(R₁₈), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)₂, S(O)₂O, OS(O)₂, S(O)₂NH or NHS(O)₂, wherein each R₁₈ independently represents H or C_1-3 alkyl; and each group R₁₇ is independently selected from the group consisting of optionally substituted C_3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C_6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C_2-6 alkenylene, C_2-6 alkynylene or any combination thereof, wherein the C_3-15cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl (e.g., optionally deuterated C_1-3 alkyl, such as methyl, CD₃, ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy (e.g., C_1-3 alkoxy, such as methoxy, ethoxy, or propoxy), C_1-4 alkyl-NH— (e.g., C_1-3 alkyl-NH—, such as CH₃NH—, CH₃CH₂NH— or CH₃CH₂CH₂NH—), halogenated C_1-4 alkyl (e.g., halogenated C_1-3 alkyl, such as F₃C—, FCH₂—, F₂CH—, ClCH₂—, Cl₂CH—, CF₃CF₂—, CF₃CHF—, CHF₂CF₂—, CHF₂CHF—, CF₃CH₂— or CH₂ClCH₂—), NH₂—C_1-4 alkylene (e.g., NH₂—C_1-3 alkylene-, such as NH₂CH₂—, NH₂CH₂CH₂— and NH₂CH₂CH₂CH₂—), C_1-4 alkyl-NHC(O)— (e.g., C_1-3 alkyl-NHC(O)—, such as CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—), C_1-4 alkyl-C(O)NH— (e.g., C_1-3 alkyl-C(O)NH—, such as CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—) or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-8), L₃ represents the structure of the following formula:

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m2)_p1—(O(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(O(C(R^a11)(R^a12))_m1)_p1—(O(C(R^a13)(R^a14)_p2—(O(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(N(R_g11)(C(R^a11)(R^a12))_m2)_p1—(N(R_g11)(C(R^a13)(R^a14))_m3)_p2—(N(R_g11)(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(C(O)NH—(C(R^a13)(R^a14))_m3)_p2—(C(O)NH—(C(R^a15)(R^a16))_m4)_p3—;

—(C(R^a9)(R^a10))_m1—(C(O)NH—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—C(O)NH—(C(R^a11)(R^a12))_m2—(O(C(R^a13)(R^a14))_m3)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(NHC(O)—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(NHC(O)N—(C(R^a11)(R^a12))_m2)_p1—(O—(C(R^a13(R^a14)_m3)_p2—(O—(C(R^a15(R^a16)_m4)_p3—;

—(C(R^a9)(R^a10))_m1—C(O)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—C(S)—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—S—(C(R^a11)(R^a12))_m2—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1—(C_6-10 arylene-(C(R^a11)(R^a12))_m2)_p1—C_6-10 arylene-(C(R^a13)(R^a14))_m3—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(4- to 15-membered heterocyclylene-(C(R^a11)(R^a12))_m2)_p1-(4- to 15-membered heterocyclylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1—;

—(C(R^a9)(R^a10))_m1-(5- to 15-membered heteroarylene-(C(R^a11)(R^a12))_m2)_p1-(5- to 15-membered heteroarylene-(C(R^a13)(R^a14))_m3)_p2—;

—(C(R^a9)(R^a10))_m1—(C_3-15 cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—; or

—(C(R^a9)(R^a10))_m1—(C_3-15cycloalkylene-(C(R^a11)(R^a12))_m2)_p1—(C_3-15cycloalkylene-(C(R^a13)(R^a14))_m3)_p2—;

• • wherein each R_g11 independently represents H or C_1-3 alkyl;
  • the C_3-15 cycloalkylene, the C_6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof;
  • R^a9, R^a10, R^a11, R^a12, R^a13, R^a14, R^a15 and R^a16 each independently represent H, deuterium, halogen, C_1-4 alkyl, C_3-6cycloalkyl or any combination thereof; and
  • m1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

In some embodiments of the compound of Formula (I-8), L₃ represents the structure of the following formula:

• • —CH₂—O—CH₂—, —CH₂—O—(CH₂)₂—, —(CH₂)₁—O—(CH₂)₃—, —(CH₂)₁—O—(CH₂)₄—, —(CH₂)₁—O—(CH₂)₅—, —(CH₂)₁—O—(CH₂)₆—, —(CH₂)₁—O—(CH₂)₇—, —(CH₂)₁—O—(CH₂)₈—, —(CH₂)₁—O—(CH₂)₉—, —(CH₂)₁—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁—, —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—O—(CH₂)₄—, —(CH₂)₂—O—(CH₂)₅—, —(CH₂)₂—O—(CH₂)₆—, —(CH₂)₂—O—(CH₂)₇—, —(CH₂)₂—O—(CH₂)₈—, —(CH₂)₂—O—(CH₂)₉—, —(CH₂)₂—O—(CH₂)₁₀—, —(CH₂)₂—O—(CH₂)₁₁—, —(CH₂)₂—O—(CH₂)₁₂—, —(CH₂)₃—O—(CH₂)₁—, —(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—O—(CH₂)₃—, —(CH₂)₃—O—(CH₂)₄—, —(CH₂)₃—O—(CH₂)₅—, —(CH₂)₃—O—(CH₂)₆—, —(CH₂)₃—O—(CH₂)₇—, —(CH₂)₄—O—(CH₂)₁—, —(CH₂)₄—O—(CH₂)₂—, —(CH₂)₄—O—(CH₂)₃—, —(CH₂)₄—O—(CH₂)₄—, —(CH₂)₄—O—(CH₂)₅—, —(CH₂)₄—O—(CH₂)₆—, —(CH₂)₅—O—(CH₂)₁—, —(CH₂)₅—O—(CH₂)₂—, —(CH₂)₅—O—(CH₂)₃—, —(CH₂)₅—O—(CH₂)₄—, —(CH₂)₅—O—(CH₂)₅—, —(CH₂)₆—O—(CH₂)₁—, —(CH₂)₆—O—(CH₂)₂—, —(CH₂)₆—O—(CH₂)₃—, —(CH₂)₆—O—(CH₂)₄—, —(CH₂)₇—O—(CH₂)₁—, —(CH₂)₇—O—(CH₂)₂—, —(CH₂)₇—O—(CH₂)₃—, —(CH₂)₈—O—(CH₂)₁—, —(CH₂)₈—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₁—, —CH(CH₃)—O—(CH₂)₂—, —CH(CH₃)—O—(CH₂)₃—, —CH(CH₃)—O—(CH₂)₄—, —CH(CH₃)—O—(CH₂)₅—, —CH(CH₃)—O—(CH₂)₆—, —CH(CH₃)—O—(CH₂)₇—, —CH(CH₃)—O—(CH₂)₈—, —CH(CH₃)—O—(CH₂)₉—, —CH(CH₃)—O—(CH₂)₁₀—, —CH₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₂)₆—, —CH₂—(O(CH₂)₂)₇—, —CH₂—(O(CH₂)₂)₈—, —CH₂—(O(CH₂)₂)₉—, —CH₂—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₂)₁—OCH₂—, —CH₂—(O(CH₂)₂)₂—OCH₂—, —CH₂—(O(CH₂)₂)₃—OCH₂—, —CH₂—(O(CH₂)₂)₄—OCH₂—, —CH₂—(O(CH₂)₂)₅—OCH₂—, —CH₂—(O(CH₂)₂)₆—OCH₂—, —CH₂—(O(CH₂)₂)₇—OCH₂—, —CH₂—(O(CH₂)₂)₈—OCH₂—, —CH₂—(O(CH₂)₂)₉—OCH₂—, —CH₂—(O(CH₂)₂)₁₀—OCH₂—, —(CH₂)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₂)₆—, —(CH₂)₂—(O(CH₂)₂)₇—, —(CH₂)₂—(O(CH₂)₂)₈—, —(CH₂)₂—(O(CH₂)₂)₉—, —(CH₂)₂—(O(CH₂)₂)₁₀—, —(CH₂)₃—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₂)₆—, —(CH₂)₃—(O(CH₂)₂)₇—, —(CH₂)₃—(O(CH₂)₂)₈—, —(CH₂)₃—(O(CH₂)₂)₉—, —(CH₂)₃—(O(CH₂)₂)₁₀—, —(CH₂)₄—(O(CH₂)₂)₂—, —(CH₂)₄—(O(CH₂)₂)₃—, —(CH₂)₄—(O(CH₂)₂)₄—, —(CH₂)₄—(O(CH₂)₂)₅—, —(CH₂)₄—(O(CH₂)₂)₆—, —(CH₂)₄—(O(CH₂)₂)₇—, —(CH₂)₄—(O(CH₂)₂)₈—, —(CH₂)₄—(O(CH₂)₂)₉—, —(CH₂)₄—(O(CH₂)₂)₁₀—, —CH₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₃)₆—, —CH₂—(O(CH₂)₃)₇—, —CH₂—(O(CH₂)₃)₈—, —CH₂—(O(CH₂)₃)₉—, —CH₂—(O(CH₂)₃)₁₀—, —(CH₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₃)₆—, —(CH₂)₂—(O(CH₂)₃)₇—, —(CH₂)₂—(O(CH₂)₃)₈—, —(CH₂)₂—(O(CH₂)₃)₉—, —(CH₂)₂—(O(CH₂)₃)₁₀—, —(CH₂)₃—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₃)₆—, —(CH₂)₃—(O(CH₂)₃)₇—, —(CH₂)₃—(O(CH₂)₃)₈—, —(CH₂)₃—(O(CH₂)₃)₉—, —(CH₂)₃—(O(CH₂)₃)₁₀—, —CH₂—O—(CH₂)₂—O—(CH₂)₃—, —CH₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —CH₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —CH₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —CH₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —CH₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₂—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₂—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₂—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₂—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₂—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —(CH₂)₃—O—(CH₂)₂—O—(CH₂)₃—, —(CH₂)₃—(O(CH₂)₂)₂—(O(CH₂)₃)₂—, —(CH₂)₃—(O(CH₂)₂)₃—(O(CH₂)₃)₃—, —(CH₂)₃—(O(CH₂)₂)₄—(O(CH₂)₃)₄—, —(CH₂)₃—(O(CH₂)₂)₅—(O(CH₂)₃)₅—, —(CH₂)₃—(O(CH₂)₂)₆—(O(CH₂)₃)₆—, —CH₂—O—(CH₂)₃—O—(CH₂)₂—, —CH₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —CH₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —CH₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —CH₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —CH₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₂—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₂—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₂—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₂—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₂—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₂—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —(CH₂)₃—O—(CH₂)₃—O—(CH₂)₂—, —(CH₂)₃—(O(CH₂)₃)₂—(O(CH₂)₂)₂—, —(CH₂)₃—(O(CH₂)₃)₃—(O(CH₂)₂)₃—, —(CH₂)₃—(O(CH₂)₃)₄—(O(CH₂)₂)₄—, —(CH₂)₃—(O(CH₂)₃)₅—(O(CH₂)₂)₅—, —(CH₂)₃—(O(CH₂)₃)₆—(O(CH₂)₂)₆—, —CH₂—O—(CH₂)₂—O—CH₂—, —(CH₂)₂—O—(CH₂)₂O—CH₂—, —(CH₂)₂—(O(CH₂)₂)₂—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₃—O—(CH₂)₃—, —(CH₂)₂—(O(CH₂)₂)₄—O—(CH₂)₃—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₅—, —(CH₂)₅—(O(CH₂)₂)₂—O—(CH₂)₆—, —CH₂—C(O)—CH₂—, —CH₂—C(O)—(CH₂)₂—, —(CH₂)₁—C(O)—(CH₂)₃—, —(CH₂)₁—C(O)—(CH₂)₄—, —(CH₂)₁—C(O)—(CH₂)₅—, —(CH₂)₁—C(O)—(CH₂)₆—, —(CH₂)₁—C(O)—(CH₂)₇—, —(CH₂)₁—C(O)—(CH₂)₈—, —(CH₂)₁—C(O)—(CH₂)₉—, —(CH₂)₁—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁—, —(CH₂)₂—C(O)—(CH₂)₂—, —(CH₂)₂—C(O)—(CH₂)₃—, —(CH₂)₂—C(O)—(CH₂)₄—, —(CH₂)₂—C(O)—(CH₂)₅—, —(CH₂)₂—C(O)—(CH₂)₆—, —(CH₂)₂—C(O)—(CH₂)₇—, —(CH₂)₂—C(O)—(CH₂)₈—, —(CH₂)₂—C(O)—(CH₂)₉—, —(CH₂)₂—C(O)—(CH₂)₁₀—, —(CH₂)₂—C(O)—(CH₂)₁₁—, —(CH₂)₂—C(O)—(CH₂)₁₂—, —(CH₂)₃—C(O)—(CH₂)₁—, —(CH₂)₃—C(O)—(CH₂)₂—, —(CH₂)₃—C(O)—(CH₂)₃—, —(CH₂)₃—C(O)—(CH₂)₄—, —(CH₂)₃—C(O)—(CH₂)₅—, —(CH₂)₃—C(O)—(CH₂)₆—, —(CH₂)₃—C(O)—(CH₂)₇—, —(CH₂)₄—C(O)—(CH₂)₁—, —(CH₂)₄—C(O)—(CH₂)₂—, —(CH₂)₄—C(O)—(CH₂)₃—, —(CH₂)₄—C(O)—(CH₂)₄—, —(CH₂)₄—C(O)—(CH₂)₅—, —(CH₂)₄—C(O)—(CH₂)₆—, —(CH₂)₅—C(O)—(CH₂)₁—, —(CH₂)₅—C(O)—(CH₂)₂—, —(CH₂)₅—C(O)—(CH₂)₃—, —(CH₂)₅—C(O)—(CH₂)₄—, —(CH₂)₅—C(O)—(CH₂)₅—, —(CH₂)₆—C(O)—(CH₂)₁—, —(CH₂)₆—C(O)—(CH₂)₂—, —(CH₂)₆—C(O)—(CH₂)₃—, —(CH₂)₆—C(O)—(CH₂)₄—, —(CH₂)₇—C(O)—(CH₂)₁—, —(CH₂)₇—C(O)—(CH₂)₂—, —(CH₂)₇—C(O)—(CH₂)₃—, —(CH₂)₈—C(O)—(CH₂)₁—, —(CH₂)₈—C(O)—(CH₂)₂—, —CH₂—S—CH₂—, —CH₂—S—(CH₂)₂—, —(CH₂)₁—S—(CH₂)₃—, —(CH₂)₁—S—(CH₂)₄—, —(CH₂)₁—S—(CH₂)₅—, —(CH₂)₁—S—(CH₂)₆—, —(CH₂)₁—S—(CH₂)₇—, —(CH₂)₁—S—(CH₂)₈—, —(CH₂)₁—S—(CH₂)₉—, —(CH₂)₁—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁—, —(CH₂)₂—S—(CH₂)₂—, —(CH₂)₂—S—(CH₂)₃—, —(CH₂)₂—S—(CH₂)₄—, —(CH₂)₂—S—(CH₂)₅—, —(CH₂)₂—S—(CH₂)₆—, —(CH₂)₂—S—(CH₂)₇—, —(CH₂)₂—S—(CH₂)₈—, —(CH₂)₂—S—(CH₂)₉—, —(CH₂)₂—S—(CH₂)₁₀—, —(CH₂)₂—S—(CH₂)₁₁—, —(CH₂)₂—S—(CH₂)₁₂—, —(CH₂)₃—S—(CH₂)₁—, —(CH₂)₃—S—(CH₂)₂—, —(CH₂)₃—S—(CH₂)₃—, —(CH₂)₃—S—(CH₂)₄—, —(CH₂)₃—S—(CH₂)₅—, —(CH₂)₃—S—(CH₂)₆—, —(CH₂)₃—S—(CH₂)₇—, —(CH₂)₄—S—(CH₂)₁—, —(CH₂)₄—S—(CH₂)₂—, —(CH₂)₄—S—(CH₂)₃—, —(CH₂)₄—S—(CH₂)₄—, —(CH₂)₄—S—(CH₂)₅—, —(CH₂)₄—S—(CH₂)₆—, —(CH₂)₅—S—(CH₂)₁—, —(CH₂)₅—S—(CH₂)₂—, —(CH₂)₅—S—(CH₂)₃—, —(CH₂)₅—S—(CH₂)₄—, —(CH₂)₅—S—(CH₂)₅—, —(CH₂)₆—S—(CH₂)₁—, —(CH₂)₆—S—(CH₂)₂—, —(CH₂)₆—S—(CH₂)₃—, —(CH₂)₆—S—(CH₂)₄—, —(CH₂)₇—S—(CH₂)₁—, —(CH₂)₇—S—(CH₂)₂—, —(CH₂)₇—S—(CH₂)₃—, —(CH₂)₈—S—(CH₂)₁—, —(CH₂)₈—S—(CH₂)₂—, —CH₂—C(S)—CH₂—, —CH₂—C(S)—(CH₂)₂—, —(CH₂)₁—C(S)—(CH₂)₃—, —(CH₂)₁—C(S)—(CH₂)₄—, —(CH₂)₁—C(S)—(CH₂)₅—, —(CH₂)₁—C(S)—(CH₂)₆—, —(CH₂)₁—C(S)—(CH₂)₇—, —(CH₂)₁—C(S)—(CH₂)₈—, —(CH₂)₁—C(S)—(CH₂)₉—, —(CH₂)₁—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁—, —(CH₂)₂—C(S)—(CH₂)₂—, —(CH₂)₂—C(S)—(CH₂)₃—, —(CH₂)₂—C(S)—(CH₂)₄—, —(CH₂)₂—C(S)—(CH₂)₅—, —(CH₂)₂—C(S)—(CH₂)₆—, —(CH₂)₂—C(S)—(CH₂)₇—, —(CH₂)₂—C(S)—(CH₂)₈—, —(CH₂)₂—C(S)—(CH₂)₉—, —(CH₂)₂—C(S)—(CH₂)₁₀—, —(CH₂)₂—C(S)—(CH₂)₁₁—, —(CH₂)₂—C(S)—(CH₂)₁₂—, —(CH₂)₃—C(S)—(CH₂)₁—, —(CH₂)₃—C(S)—(CH₂)₂—, —(CH₂)₃—C(S)—(CH₂)₃—, —(CH₂)₃—C(S)—(CH₂)₄—, —(CH₂)₃—C(S)—(CH₂)₅—, —(CH₂)₃—C(S)—(CH₂)₆—, —(CH₂)₃—C(S)—(CH₂)₇—, —(CH₂)₄—C(S)—(CH₂)₁—, —(CH₂)₄—C(S)—(CH₂)₂—, —(CH₂)₄—C(S)—(CH₂)₃—, —(CH₂)₄—C(S)—(CH₂)₄—, —(CH₂)₄—C(S)—(CH₂)₅—, —(CH₂)₄—C(S)—(CH₂)₆—, —(CH₂)₅—C(S)—(CH₂)₁—, —(CH₂)₅—C(S)—(CH₂)₂—, —(CH₂)₅—C(S)—(CH₂)₃—, —(CH₂)₅—C(S)—(CH₂)₄—, —(CH₂)₅—C(S)—(CH₂)₅—, —(CH₂)₆—C(S)—(CH₂)₁—, —(CH₂)₆—C(S)—(CH₂)₂—, —(CH₂)₆—C(S)—(CH₂)₃—, —(CH₂)₆—C(S)—(CH₂)₄—, —(CH₂)₇—C(S)—(CH₂)₁—, —(CH₂)₇—C(S)—(CH₂)₂—, —(CH₂)₇—C(S)—(CH₂)₃—, —(CH₂)₈—C(S)—(CH₂)₁—, —(CH₂)₈—C(S)—(CH₂)₂—, —CH₂—C(O)O—CH₂—, —CH₂—C(O)O—(CH₂)₂—, —(CH₂)₁—C(O)O—(CH₂)₃—, —(CH₂)₁—C(O)O—(CH₂)₄—, —(CH₂)₁—C(O)O—(CH₂)₅—, —(CH₂)₁—C(O)O—(CH₂)₆—, —(CH₂)₁—C(O)O—(CH₂)₇—, —(CH₂)₁—C(O)O—(CH₂)₈—, —(CH₂)₁—C(O)O—(CH₂)₉—, —(CH₂)₁—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁—, —(CH₂)₂—C(O)O—(CH₂)₂—, —(CH₂)₂—C(O)O—(CH₂)₃—, —(CH₂)₂—C(O)O—(CH₂)₄—, —(CH₂)₂—C(O)O—(CH₂)₅—, —(CH₂)₂—C(O)O—(CH₂)₆—, —(CH₂)₂—C(O)O—(CH₂)₇—, —(CH₂)₂—C(O)O—(CH₂)₈—, —(CH₂)₂—C(O)O—(CH₂)₉—, —(CH₂)₂—C(O)O—(CH₂)₁₀—, —(CH₂)₂—C(O)O—(CH₂)₁₁—, —(CH₂)₂—C(O)O—(CH₂)₁₂—, —(CH₂)₃—C(O)O—(CH₂)₁—, —(CH₂)₃—C(O)O—(CH₂)₂—, —(CH₂)₃—C(O)O—(CH₂)₃—, —(CH₂)₃—C(O)O—(CH₂)₄—, —(CH₂)₃—C(O)O—(CH₂)₅—, —(CH₂)₃—C(O)O—(CH₂)₆—, —(CH₂)₃—C(O)O—(CH₂)₇—, —(CH₂)₄—C(O)O—(CH₂)₁—, —(CH₂)₄—C(O)O—(CH₂)₂—, —(CH₂)₄—C(O)O—(CH₂)₃—, —(CH₂)₄—C(O)O—(CH₂)₄—, —(CH₂)₄—C(O)O—(CH₂)₅—, —(CH₂)₄—C(O)O—(CH₂)₆—, —(CH₂)₅—C(O)O—(CH₂)₁—, —(CH₂)₅—C(O)O—(CH₂)₂—, —(CH₂)₅—C(O)O—(CH₂)₃—, —(CH₂)₅—C(O)O—(CH₂)₄—, —(CH₂)₅—C(O)O—(CH₂)₅—, —(CH₂)₆—C(O)O—(CH₂)₁—, —(CH₂)₆—C(O)O—(CH₂)₂—, —(CH₂)₆—C(O)O—(CH₂)₃—, —(CH₂)₆—C(O)O—(CH₂)₄—, —(CH₂)₇—C(O)O—(CH₂)₁—, —(CH₂)₇—C(O)O—(CH₂)₂—, —(CH₂)₇—C(O)O—(CH₂)₃—, —(CH₂)₈—C(O)O—(CH₂)₁—, —(CH₂)₈—C(O)O—(CH₂)₂—, —CH₂—OC(O)—CH₂—, —CH₂—OC(O)—(CH₂)₂—, —(CH₂)₁—OC(O)—(CH₂)₃—, —(CH₂)₁—OC(O)—(CH₂)₄—, —(CH₂)₁—OC(O)—(CH₂)₅—, —(CH₂)₁—OC(O)—(CH₂)₆—, —(CH₂)₁—OC(O)—(CH₂)₇—, —(CH₂)₁—OC(O)—(CH₂)₈—, —(CH₂)₁—OC(O)—(CH₂)₉—, —(CH₂)₁—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁—, —(CH₂)₂—OC(O)—(CH₂)₂—, —(CH₂)₂—OC(O)—(CH₂)₃—, —(CH₂)₂—OC(O)—(CH₂)₄—, —(CH₂)₂—OC(O)—(CH₂)₅—, —(CH₂)₂—OC(O)—(CH₂)₆—, —(CH₂)₂—OC(O)—(CH₂)₇—, —(CH₂)₂—OC(O)—(CH₂)₈—, —(CH₂)₂—OC(O)—(CH₂)₉—, —(CH₂)₂—OC(O)—(CH₂)₁₀—, —(CH₂)₂—OC(O)—(CH₂)₁₁—, —(CH₂)₂—OC(O)—(CH₂)₁₂—, —(CH₂)₃—OC(O)—(CH₂)₁—, —(CH₂)₃—OC(O)—(CH₂)₂—, —(CH₂)₃—OC(O)—(CH₂)₃—, —(CH₂)₃—OC(O)—(CH₂)₄—, —(CH₂)₃—OC(O)—(CH₂)₅—, —(CH₂)₃—OC(O)—(CH₂)₆—, —(CH₂)₃—OC(O)—(CH₂)₇—, —(CH₂)₄—OC(O)—(CH₂)₁—, —(CH₂)₄—OC(O)—(CH₂)₂—, —(CH₂)₄—OC(O)—(CH₂)₃—, —(CH₂)₄—OC(O)—(CH₂)₄—, —(CH₂)₄—OC(O)—(CH₂)₅—, —(CH₂)₄—OC(O)—(CH₂)₆—, —(CH₂)₅—OC(O)—(CH₂)₁—, —(CH₂)₅—OC(O)—(CH₂)₂—, —(CH₂)₅—OC(O)—(CH₂)₃—, —(CH₂)₅—OC(O)—(CH₂)₄—, —(CH₂)₅—OC(O)—(CH₂)₅—, —(CH₂)₆—OC(O)—(CH₂)₁—, —(CH₂)₆—OC(O)—(CH₂)₂—, —(CH₂)₆—OC(O)—(CH₂)₃—, —(CH₂)₆—OC(O)—(CH₂)₄—, —(CH₂)₇—OC(O)—(CH₂)₁—, —(CH₂)₇—OC(O)—(CH₂)₂—, —(CH₂)₇—OC(O)—(CH₂)₃—, —(CH₂)₈—OC(O)—(CH₂)₁—, —(CH₂)₈—OC(O)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₁—, —(CH₂)₁—N(R_g11)—(CH₂)₂—, —(CH₂)₁—N(R_g11)—(CH₂)₃—, —(CH₂)₁—N(R_g11)—(CH₂)₄—, —(CH₂)₁—N(R_g11)—(CH₂)₅—, —(CH₂)₁—N(R_g11)—(CH₂)₆—, —(CH₂)₁—N(R_g11)—(CH₂)₇—, —(CH₂)₁—N(R_g11)—(CH₂)₈—, —(CH₂)₁—N(R_g11)—(CH₂)₉—, —(CH₂)₁—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₂—, —(CH₂)₂—N(R_g11)—(CH₂)₃—, —(CH₂)₂—N(R_g11)—(CH₂)₄—, —(CH₂)₂—N(R_g11)—(CH₂)₈—, —(CH₂)₂—N(R_g11)—(CH₂)₆—, —(CH₂)₂—N(R_g11)—(CH₂)₇—, —(CH₂)₂—N(R_g11)—(CH₂)₈—, —(CH₂)₂—N(R_g11)—(CH₂)₉—, —(CH₂)₂—N(R_g11)—(CH₂)₁₀—, —(CH₂)₂—N(R_g11)—(CH₂)₁—, —(CH₂)₂—N(R_g11)—(CH₂)₁₂—, —(CH₂)₃—N(R_g11)—(CH₂)₁—, —(CH₂)₃—N(R_g11)—(CH₂)₂—, —(CH₂)₃—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₁—, —(CH₂)₄—N(R_g11)—(CH₂)₂—, —(CH₂)₄—N(R_g11)—(CH₂)₃—, —(CH₂)₄—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₁—, —(CH₂)₅—N(R_g11)—(CH₂)₂—, —(CH₂)₅—N(R_g11)—(CH₂)₃—, —(CH₂)₅—N(R_g11)—(CH₂)₄—, —(CH₂)₅—N(R_g11)—(CH₂)₅—, —(CH₂)₆—N(R_g11)—(CH₂)₁—, —(CH₂)₆—N(R_g11)—(CH₂)₂—, —(CH₂)₆—N(R_g11)—(CH₂)₃—, —(CH₂)₇—N(R_g11)—(CH₂)₁—, —(CH₂)₇—N(R_g11)—(CH₂)₂—, —(CH₂)₇—N(R_g11)—(CH₂)₃—, —(CH₂)₈—N(R_g11)—(CH₂)₁—, —(CH₂)₈—N(R_g11)—(CH₂)₂—, —(CH₂)₈—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₁—, —CH(CH₃)—N(R_g11)—(CH₂)₂—, —CH(CH₃)—N(R_g11)—(CH₂)₃—, —CH(CH₃)—N(R_g11)—(CH₂)₄—, —CH(CH₃)—N(R_g11)—(CH₂)₈—, —CH(CH₃)—N(R_g11)—(CH₂)₆—, —CH(CH₃)—N(R_g11)—(CH₂)₇—, —CH(CH₃)—N(R_g11)—(CH₂)₈—, —CH(CH₃)—N(R_g11)—(CH₂)₉—, —CH(CH₃)—N(R_g11)—(CH₂)₁₀—, —CH₂C(O)NHCH₂—, —(CH₂)₂C(O)NH(CH₂)₂—, —(CH₂)₂C(O)NH(CH₂)₃—, —(CH₂)₂C(O)NH(CH₂)₄—, —(CH₂)₂C(O)NH(CH₂)₅—, —(CH₂)₃C(O)NH(CH₂)₃—, —(CH₂)₃C(O)NH(CH₂)₄—, —(CH₂)₄C(O)NH(CH₂)₄—, —(CH₂)₅C(O)NH(CH₂)₅—, —(CH₂)₆C(O)NH(CH₂)₇—, —(CH₂)₆C(O)NH(CH₂)₆—, —(CH₂)₇C(O)NH(CH₂)₇—, —(CH₂)₈C(O)NH(CH₂)₈, —(CH₂)₉C(O)NH(CH₂)₉—, —(CH₂)₁₀C(O)NH(CH₂)₁₀—, —(CH₂)₂C(O)NH(CH₂)₂—O—(CH₂)₂—, —CH₂NHC(O)CH₂—, —(CH₂)₂NHC(O)(CH₂)₂—, —(CH₂)₂NHC(O)(CH₂)₃—, —(CH₂)₂NHC(O)(CH₂)₄—, —(CH₂)₂NHC(O)(CH₂)₅—, —(CH₂)₃NHC(O)(CH₂)₃—, —(CH₂)₃NHC(O)(CH₂)₄—, —(CH₂)₄NHC(O)(CH₂)₄—, —(CH₂)₅NHC(O)(CH₂)₅—, —(CH₂)₆NHC(O)(CH₂)₇—, —(CH₂)₆NHC(O)(CH₂)₆—, —(CH₂)₇NHC(O)(CH₂)₇—, —(CH₂)₈NHC(O)(CH₂)₈, —(CH₂)₉NHC(O)(CH₂)₉—, —(CH₂)₁₀NHC(O)(CH₂)₁₀—, —(CH₂)₄NHC(O)(CH₂)₈—, —(CH₂)₂NHC(O)(CH₂)₂—O—(CH₂)₂—, —(CH₂)₄NHC(O)CH₂—, —CH₂-piperidinylene-CH₂—, —CH₂-piperidinylene-(CH₂)₂—, —CH₂-piperidinylene-(CH₂)₃—, —CH₂-piperidinylene-(CH₂)₄—, —CH₂-piperidinylene-(CH₂)₅—, —CH₂-piperidinylene-(CH₂)₆—, —CH₂-piperidinylene-(CH₂)₇—, —CH₂-piperidinylene-(CH₂)₈—, —(CH₂)₂-piperidinylene-(CH₂)₁—, —(CH₂)₂-piperidinylene-(CH₂)₂—, —(CH₂)₂-piperidinylene-(CH₂)₃—, —(CH₂)₂-piperidinylene-(CH₂)₄—, —(CH₂)₂-piperidinylene-(CH₂)₅—, —(CH₂)₂-piperidinylene-(CH₂)₆—, —(CH₂)₂-piperidinylene-(CH₂)₇—, —(CH₂)₂-piperidinylene-(CH₂)₈—, —(CH₂)₃-piperidinylene-CH₂—, —(CH₂)₃-piperidinylene-(CH₂)₂—, —(CH₂)₃-piperidinylene-(CH₂)₃—, —(CH₂)₃-piperidinylene-(CH₂)₄—, —(CH₂)₃-piperidinylene-(CH₂)₅—, —(CH₂)₃-piperidinylene-(CH₂)₆—, —(CH₂)₃-piperidinylene-(CH₂)₇—, —(CH₂)₃-piperidinylene-(CH₂)₈—, —(CH₂)₄-piperidinylene-CH₂—, —(CH₂)₄-piperidinylene-(CH₂)₂—, —(CH₂)₄-piperidinylene-(CH₂)₃—, —(CH₂)₄-piperidinylene-(CH₂)₄—, —(CH₂)₄-piperidinylene-(CH₂)₅—, —(CH₂)₄-piperidinylene-(CH₂)₆—, —(CH₂)₄-piperidinylene-(CH₂)₇—, —(CH₂)₄-piperidinylene-(CH₂)₈—, —(CH₂)₅-piperidinylene-(CH₂)₁—, —(CH₂)₅-piperidinylene-(CH₂)₂—, —(CH₂)₅-piperidinylene-(CH₂)₃—, —(CH₂)₅-piperidinylene-(CH₂)₄—, —(CH₂)₅-piperidinylene-(CH₂)₅—, —(CH₂)₅-piperidinylene-(CH₂)₆—, —(CH₂)₅-piperidinylene-(CH₂)₇—, —(CH₂)₅-piperidinylene-(CH₂)₈—, —(CH₂)₆-piperidinylene-(CH₂)₁—, —(CH₂)₆-piperidinylene-(CH₂)₂—, —(CH₂)₆-piperidinylene-(CH₂)₃—, —(CH₂)₆-piperidinylene-(CH₂)₄—, —(CH₂)₆-piperidinylene-(CH₂)₅—, —(CH₂)₆-piperidinylene-(CH₂)₆—, —(CH₂)₆-piperidinylene-(CH₂)₇—, —(CH₂)₆-piperidinylene-(CH₂)₈—, —(CH₂)₇-piperidinylene-(CH₂)₁—, —(CH₂)₇-piperidinylene-(CH₂)₂—, —(CH₂)₇-piperidinylene-(CH₂)₃—, —(CH₂)₇-piperidinylene-(CH₂)₄—, —(CH₂)₇-piperidinylene-(CH₂)₈—, —(CH₂)₈-piperidinylene-CH₂—, —(CH₂)₈-piperidinylene-(CH₂)₂—, —(CH₂)₈-piperidinylene-(CH₂)₃—, —(CH₂)₈-piperidinylene-(CH₂)₄—, —(CH₂)₈-piperidinylene-(CH₂)₅—, —(CH₂)₈-piperidinylene-(CH₂)₆—, —(CH₂)₈-piperidinylene-(CH₂)₇—, —(CH₂)₈-piperidinylene-(CH₂)₈—, —CH₂-piperazinylene-CH₂—, —CH₂-piperazinylene-(CH₂)₂—, —CH₂-piperazinylene-(CH₂)₃—, —CH₂-piperazinylene-(CH₂)₄—, —CH₂-piperazinylene-(CH₂)₅—, —CH₂-piperazinylene-(CH₂)₆—, —CH₂-piperazinylene-(CH₂)₇—, —CH₂-piperazinylene-(CH₂)₈—, —(CH₂)₂-piperazinylene-(CH₂)₁—, —(CH₂)₂-piperazinylene-(CH₂)₂—, —(CH₂)₂-piperazinylene-(CH₂)₃—, —(CH₂)₂-piperazinylene-(CH₂)₄—, —(CH₂)₂-piperazinylene-(CH₂)₅—, —(CH₂)₂-piperazinylene-(CH₂)₆—, —(CH₂)₂-piperazinylene-(CH₂)₇—, —(CH₂)₂-piperazinylene-(CH₂)₈—, —(CH₂)₃-piperazinylene-CH₂—, —(CH₂)₃-piperazinylene-(CH₂)₂—, —(CH₂)₃-piperazinylene-(CH₂)₃—, —(CH₂)₃-piperazinylene-(CH₂)₄—, —(CH₂)₃-piperazinylene-(CH₂)₅—, —(CH₂)₃-piperazinylene-(CH₂)₆—, —(CH₂)₃-piperazinylene-(CH₂)₇—, —(CH₂)₃-piperazinylene-(CH₂)₈—, —(CH₂)₄-piperazinylene-CH₂—, —(CH₂)₄-piperazinylene-(CH₂)₂—, —(CH₂)₄-piperazinylene-(CH₂)₃—, —(CH₂)₄-piperazinylene-(CH₂)₄—, —(CH₂)₄-piperazinylene-(CH₂)₅—, —(CH₂)₄-piperazinylene-(CH₂)₆—, —(CH₂)₄-piperazinylene-(CH₂)₇—, —(CH₂)₄-piperazinylene-(CH₂)₈—, —(CH₂)₅-piperazinylene-(CH₂)₁—, —(CH₂)₅-piperazinylene-(CH₂)₂—, —(CH₂)₅-piperazinylene-(CH₂)₃—, —(CH₂)₅-piperazinylene-(CH₂)₄—, —(CH₂)₅-piperazinylene-(CH₂)₅—, —(CH₂)₅-piperazinylene-(CH₂)₆—, —(CH₂)₈-piperazinylene-(CH₂)₇—, —(CH₂)₅-piperazinylene-(CH₂)₈—, —(CH₂)₆-piperazinylene-(CH₂)₁—, —(CH₂)₆-piperazinylene-(CH₂)₂—, —(CH₂)₆-piperazinylene-(CH₂)₃—, —(CH₂)₆-piperazinylene-(CH₂)₄—, —(CH₂)₆-piperazinylene-(CH₂)₅—, —(CH₂)₆-piperazinylene-(CH₂)₆—, —(CH₂)₆-piperazinylene-(CH₂)₇—, —(CH₂)₆-piperazinylene-(CH₂)₈—, —(CH₂)₇-piperazinylene-(CH₂)₁—, —(CH₂)₇-piperazinylene-(CH₂)₂—, —(CH₂)₇-piperazinylene-(CH₂)₃—, —(CH₂)₇-piperazinylene-(CH₂)₄—, —(CH₂)₇-piperazinylene-(CH₂)₈—, —(CH₂)₈-piperazinylene-CH₂—, —(CH₂)₈-piperazinylene-(CH₂)₂—, —(CH₂)₈-piperazinylene-(CH₂)₃—, —(CH₂)₈-piperazinylene-(CH₂)₄—, —(CH₂)₈-piperazinylene-(CH₂)₅—, —(CH₂)₈-piperazinylene-(CH₂)₆—, —(CH₂)₈-piperazinylene-(CH₂)₇—, —(CH₂)₈-piperazinylene-(CH₂)₈—, —CH₂-propylene-CH₂—, —CH₂-propylene-(CH₂)₂—, —CH₂-propylene-(CH₂)₃—, —CH₂-propylene-(CH₂)₄—, —CH₂-propylene-(CH₂)₅—, —CH₂-propylene-(CH₂)₆—, —CH₂-propylene-(CH₂)₇—, —CH₂-propylene-(CH₂)₈—, —(CH₂)₂-propylene-(CH₂)₁—, —(CH₂)₂-propylene-(CH₂)₂—, —(CH₂)₂-propylene-(CH₂)₃—, —(CH₂)₂-propylene-(CH₂)₄—, —(CH₂)₂-propylene-(CH₂)₅—, —(CH₂)₂-propylene-(CH₂)₆—, —(CH₂)₂-propylene-(CH₂)₇—, —(CH₂)₂-propylene-(CH₂)₈—, —(CH₂)₃-propylene-CH₂—, —(CH₂)₃-propylene-(CH₂)₂—, —(CH₂)₃-propylene-(CH₂)₃—, —(CH₂)₃-propylene-(CH₂)₄—, —(CH₂)₃-propylene-(CH₂)₅—, —(CH₂)₃-propylene-(CH₂)₆—, —(CH₂)₃-propylene-(CH₂)₇—, —(CH₂)₃-propylene-(CH₂)₈—, —(CH₂)₄-propylene-CH₂—, —(CH₂)₄-propylene-(CH₂)₂—, —(CH₂)₄-propylene-(CH₂)₃—, —(CH₂)₄-propylene-(CH₂)₄—, —(CH₂)₄-propylene-(CH₂)₅—, —(CH₂)₄-propylene-(CH₂)₆—, —(CH₂)₄-propylene-(CH₂)₇—, —(CH₂)₄-propylene-(CH₂)₈—, —(CH₂)₅-propylene-(CH₂)₁—, —(CH₂)₅-propylene-(CH₂)₂—, —(CH₂)₅-propylene-(CH₂)₃—, —(CH₂)₅-propylene-(CH₂)₄—, —(CH₂)₅-propylene-(CH₂)₅—, —(CH₂)₅-propylene-(CH₂)₆—, —(CH₂)₅-propylene-(CH₂)₇—, —(CH₂)₅-propylene-(CH₂)₈—, —(CH₂)₆-propylene-(CH₂)₁—, —(CH₂)₆-propylene-(CH₂)₂—, —(CH₂)₆-propylene-(CH₂)₃—, —(CH₂)₆-propylene-(CH₂)₄—, —(CH₂)₆-propylene-(CH₂)₅—, —(CH₂)₆-propylene-(CH₂)₆—, —(CH₂)₆-propylene-(CH₂)₇—, —(CH₂)₆-propylene-(CH₂)₈—, —(CH₂)₇-propylene-(CH₂)₁—, —(CH₂)₇-propylene-(CH₂)₂—, —(CH₂)₇-propylene-(CH₂)₃—, —(CH₂)₇-propylene-(CH₂)₄—, —(CH₂)₇-propylene-(CH₂)₈—, —(CH₂)₈-propylene-CH₂—, —(CH₂)₈-propylene-(CH₂)₂—, —(CH₂)₈-propylene-(CH₂)₃—, —(CH₂)₈-propylene-(CH₂)₄—, —(CH₂)₈-propylene-(CH₂)₅—, —(CH₂)₈-propylene-(CH₂)₆—, —(CH₂)₈-propylene-(CH₂)₇—, —(CH₂)₈-propylene-(CH₂)₈—, —CH₂-diazacycloheptanylene-CH₂—, —CH₂-diazacycloheptanylene-(CH₂)₂—, —CH₂-diazacycloheptanylene-(CH₂)₃—, —CH₂-diazacycloheptanylene-(CH₂)₄—, —CH₂-diazacycloheptanylene-(CH₂)₅—, —CH₂-diazacycloheptanylene-(CH₂)₆—, —CH₂-diazacycloheptanylene-(CH₂)₇—, —CH₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₂-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₃-diazacycloheptanylene-CH₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₃-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₄-diazacycloheptanylene-CH₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₄-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₅-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₆-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₁—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₇-diazacycloheptanylene-(CH₂)₈—, —(CH₂)₈-diazacycloheptanylene-CH₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₂—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₃—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₄—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₅—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₆—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₇—, —(CH₂)₈-diazacycloheptanylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.1]heptanylene-CH₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[2.2.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.1.1]heptanylene-CH₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —CH₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-CH₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.1.1]heptanylene-(CH₂)₈—, —CH₂-diazabicyclo[3.2.1]octylene-CH₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —CH₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-CH₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₇—, —(CH₂)₈-diazabicyclo[3.2.1]octylene-(CH₂)₈—, —CH₂-diazabicyclo[2.2.2]octylene-CH₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —CH₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₂-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₃-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₄-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₅-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₇—, —(CH₂)₆-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₁—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₇-diazabicyclo[2.2.2]octylene-(CH₂)₈—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-CH₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₂—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₃—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₄—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₅—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₆—, —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₇—, or —(CH₂)₈-diazabicyclo[2.2.2]octylene-(CH₂)₈—;
  • wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C_1-4 alkyl, optionally deuterated C_3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH— or any combination thereof; and
  • each R_g11 independently represents H or C_1-3 alkyl.

In some embodiments of the compound of Formula (I-8), L₃ represents the structure of the following formula:

In some embodiments of the compound of Formula (I-8), R_b2 represents:

• • cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof;
  • phenyl or naphthyl, with each group being optionally substituted with one or more (e.g., 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, wherein the C_3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof; or
  • furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, optionally substituted C_3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C_6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof, wherein the C_3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C_6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) substituents selected from the group consisting of D, optionally deuterated C_1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C_1-4 alkoxy, C_1-4 alkyl-NH—, halogenated C_1-4 alkyl, NH₂—C_1-4 alkylene, C_1-4 alkyl-NHC(O)—, C_1-4 alkyl-C(O)NH—, or any combination thereof.

In some embodiments of the compound of Formula (I-8), R_b2 represents the following formula:

• • wherein R_f1, R_f2, R_f3, R_f4 and R_f5 are as defined in the compound of Formula (I-2) and the embodiments thereof.

In some embodiments of the compound of Formula (I-8), R_b2 represents:

In some embodiments, the compound of Formula (I) of the present disclosure is also of Formula (II) or Formula (III):

wherein groups R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_a, (R_1a)_n and R_b are as defined in the compound of Formula (I) above and the embodiments thereof.

In some embodiments, the compound of Formula (I) of the present disclosure is also of Formula (Ia), Formula (Ib), Formula (Ic), Formula (Id), Formula (IIa), Formula (IIb), Formula (IIc), Formula (IId), Formula (IIIa), Formula (IIIb) Formula (IIIc), or Formula (IIId):

• • wherein groups R_c1, R_c2, R_c3, R_c4, R_c5, R_c6, R_a, (R_1a) and R_b are as defined in the compound of Formula (I) above and the embodiments thereof.

Preferably the compounds of the present invention and their salts (especially pharmaceutically acceptable salts, such as hydrochloride, etc.), enantiomers, diastereomers, solvates, or polymorphs thereof in Table 1 below are provided.

TABLE 1
The compounds of the present invention
Compound
No.	Structure of the compounds	The compounds′ name in English
GT- 01818		3-(5-((4-(((3s,5s,7s)-adamantan-1- yl)amino)butyl)amino)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02280		3-(5-((5-(((1s,3s)-adamantan-1- yl)amino)pentyl)amino)- 2-methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02235		3-(5-((6-(((3s,5s,7s)-adamantan-1- yl)amino)hexyl)amino)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02237		3-(5-((7-(((1s,3s)-adamantan-1- yl)amino)heptyl)amino)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02234		3-(5-((2-(2-(((1s,3s)-adamantan-1- yl)amino)ethoxy)ethyl)amino)- 2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
GT- 02279		3-(5-((2-(2-(2-(((3s,5s,7s)- adamantan-1-yl) amino)ethoxy)ethoxy)ethyl) amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
GT- 02325		3-(5-((2-(((1r,3r,5r,7r)- adamantan-2- yl)amino)ethyl)amino)- 2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02326		3-(5-((3-(((1r,3r, 5r,7r)-adamantan-2- yl)amino)propyl) amino)-2-methyl-4- oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02392		3-(5-((4-(((1r,3r, 5r,7r)-adamantan-2- yl)amino)butyl) amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02393		3-(5-((5-(((1r,3r, 5r,7r)-adamantan-2- yl)amino)pentyl) amino)-2-methyl- 4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02496		3-(5-((5-(((3as, 6as)-hexahydro- 2,5-methanopentalen- 3a(1H)-yl)amino)pentyl) amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
GT- 02494		3-(5-((6-(((2R,3as,5S,6as)- hexahydro-2,5- methanopentalen-3a(1H)- yl)amino)hexyl)amino)-2- methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02495		3-(5-((7-(((3as, 6as)-hexahydro- 2,5-methanopentalen- 3a(1H)-yl)amino)heptyl) amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
GT- 02389		3-(5-((2-(2-(((3as,6as)- hexahydro-2,5- methanopentalen- 3a(1H)-yl)amino)ethoxy) ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
GT- 02497		3-(5-((2-(2-(2-(((2R,3as,5S, 6as)-hexahydro-2,5- methanopentalen-3a(1H)- yl)amino)ethoxy)ethoxy) ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
GT- 02500		3-(2-methyl-5- ((5-(4-methyl- 1,4-diazepan-1- yl)pentyl)amino)-4- oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02502		3-(2-methyl-5- ((7-(4-methyl- 1,4-diazepan-1- yl)heptyl)amino)-4- oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02493		3-(2-methyl-5-((2-(2-(4- methyl-1,4-diazepan-1- yl)ethoxy)ethyl)amino)- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02607		3-(5-((2-(2-hydroxyethoxy) ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
GT- 02608		3-(5-((2-(2-(6-oxa-3- azabicyclo[3.1.1]heptan-3- yl)ethoxy)ethyl)amino)-2- methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
GT- 02617		3-(2-methyl-5-((2-(2- morpholinoethoxy) ethyl)amino)-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02618		3-(2-methyl-5-((2-(2-(4- morpholinopiperidin-1- yl)ethoxy)ethyl)amino)- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02619		3-(2-methyl-5-((2-(2-(4- (4-methylpiperazin-1- yl)piperidin-1-yl)ethoxy) ethyl)amino)-4- oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02620		3-(2-methyl-5-((2-(2-(4- (oxetan-3-yl)piperazin-1- yl)ethoxy)ethyl)amino)- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02598		3-(5-((7-hydroxyheptyl) amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02621		3-(5-((7-(6-oxa-3- azabicyclo[3.1.1 ]heptan-3- yl)heptyl)amino)-2- methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
GT- 02622		3-(2-methyl-5-((7-(4- morpholinopiperidin-1- yl)heptyl)amino)-4- oxoquinazolin-3(4H)- yl)piperidine- 2,6-dione
GT- 02623		3-(2-methyl-5-((7-(4- (oxetan-3-yl)piperazin-1- yl)heptyl)amino)-4- oxoquinazolin-3(4H)- yl)piperidine- 2,6-dione
GT- 02767		3-(5-((7-(((1SR,3RS, 5SR,7r)-3,5- dimethyladamantan-1- yl)amino)heptyl)amino)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02768		3-(5-((7-((1-((3r,5r,7r)- adamantan-1- yl)ethyl)amino)heptyl) amino)-2-methyl- 4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02772		3-(5-((7-(3-azabicyclo [3.1.0]hexan-3-yl)heptyl) amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
GT- 02773		3-(5-((7-(2,2-difluoro-7- azaspiro[3.5]nonan-7- yl)heptyl)amino)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02774		3-(5-((7-((4- fluorobicyclo[2.2.2] octan-1- yl)amino)heptyl)amino)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
		3-(2-methyl-4-oxo-5- ((7-(((1R,2S,4R)-1,7,7- trimethylbicyclo[2.2.1] heptan-2- yl)amino)heptyl)amino) quinazolin-3(4H)- yl)piperidine- 2,6-dione
		3-(5-((7-((2-isopropyl-5- methylcyclohexyl)oxy) heptyl)amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
		(3S)-3-(5-((7-((1- ((3r,5r,7r)-adamantan-1- yl)ethyl)amino)heptyl) amino)-2-methyl-4- oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
		(S)-3-(5-((7-(((1SR, 3RS,5SR,7r)-3,5- dimethyladamantan- 1-yl)amino)heptyl) amino)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		(3R)-3-(5-((7-(((3as,6as)- hexahydro-2,5- methanopentalen-3a(1H)- yl)amino)heptyl)amino)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6- dione
		(3R)-3-(5-((7-(((1s, 3s)-adamantan-1- yl)amino)heptyl)amino)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
		(S)-3-(2-methyl-4-oxo- 5-((7-(((1R,2S,4R)-1,7,7- trimethylbicyclo [2.2.1]heptan-2- yl)amino)heptyl)amino) quinazolin-3(4H)-yl)piperidine- 2,6-dione
		3-(5-((7-((1-((3r,5r,7r)- adamantan-1- yl)ethyl)amino)heptyl) amino)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(5-((7-(((1SR,3RS, 5SR,7r)-3,5- dimethyladamantan-1- yl)amino)heptyl)amino)- 4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		3-(5-((7-(4-methyl-1,4- diazepan-1-yl)heptyl) amino)-4- oxo-2-(trifluoromethyl) quinazolin-3(4H)-yl)piperidine- 2,6-dione
		3-(5-((7-(((3as,6as)- hexahydro-2,5- methanopentalen- 3a(1H)-yl)amino)heptyl) amino)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		3-(5-((2-(2-(2-(((3s, 5s,7s)-adamantan-1- yl)amino)ethoxy) ethoxy)ethyl)amino)- 4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(5-((7-(((1s,3s)- adamantan-1-yl)amino) heptyl)amino)- 4-oxo-2-(trifluoromethyl) quinazolin-3(4H)-yl)piperidine- 2,6-dione
		3-(5-((7-((4- fluorobicyclo[2.2.2]octan-1- yl)amino)heptyl)amino)- 4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		3-(5-((7-(2,2-difluoro-7- azaspiro[3.5]nonan-7- yl)heptyl)amino)-4-oxo- 2-(trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-((7-((2-isopropyl-5- methylcyclohexyl)oxy) heptyl)amino)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(4-oxo-2-(trifluoromethyl)- 5-((7-(((1R,2S,4R)-1,7,7- trimethylbicyclo [2.2.1]heptan-2- yl)amino)heptyl)amino) quinazolin-3(4H)-yl)piperidine- 2,6-dione
		(S)-3-(5-((7-(((1SR, 3RS,5SR,7r)-3,5- dimethyladamantan- 1-yl)amino)heptyl) amino)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		(3S)-3-(5-((7-((1- ((3r,5r,7r)-adamantan-1- yl)ethyl)amino)heptyl )amino)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)-yl) piperidine-2,6- dione
		(3R)-3-(5-((7-(((3as, 6as)-hexahydro-2,5- methanopentalen- 3a(1H)-yl)amino) heptyl)amino)-4-oxo- 2-(trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(3R)-3-(5-((7-(((1s, 3s)-adamantan-1- yl)amino)heptyl) amino)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(S)-3-(5-((7-((4- fluorobicyclo [2.2.2]octan-1- yl)amino)heptyl) amino)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(3S)-3-(5-((7- ((2-isopropyl-5- methylcyclohexyl) oxy)heptyl) amino)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(S)-3-(4-oxo-2- (trifluoromethyl)- 5-((7-(((1R,2S,4R)- 1,7,7-trimethylbicyclo [2.2.1]heptan-2- yl)amino)heptyl) amino)quinazolin- 3(4H)-yl)piperidine- 2,6-dione
		3-(5-((7-(((1s,3s)- adamantan-1-yl)amino) heptyl)amino)- 2-butyl-4-oxoquinazolin- 3(4H)-yl) piperidine- 2,6-dione
		3-(5-((7-(((1s,3s)- adamantan-1-yl)amino) heptyl)amino)- 2-(methyl-d3)-4- oxoquinazolin-3(4H)- yl)piperidine-2,6- dione
		3-(2-(7-(((3s,5s,7s)- adamantan-1-yl) amino)heptyl)-5- bromo-4-oxoquinazolin-3 (4H)-yl)piperidine- 2,6-dione
		3-(2-(7-(((3s,5s,7s)- adamantan-1-yl) amino)heptyl)-5- fluoro-4-oxoquinazolin- 3(4H)- yl)piperidine- 2,6-dione
		2-(7-(((3s,5s,7s)- adamantan-1-yl) amino)heptyl)-3-(2,6- dioxopiperidin-3- yl)-4-oxo-3,4- dihydroquinazoline-5- carbonitrile
		3-(2-(3-(3-(((3s, 5s,7s)-adamantan-1- yl)(methyl)amino) propoxy)propyl)- 5-bromo-4- oxoquinazolin- 3(4H)-yl) piperidine-2,6-dione
GT- 02601		3-(5-(((1s,3s)-adamantan- 1-yl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(4-(3-(((3s,5s,7s)- adamantan-1- yl)amino)propyl)piperazin- 1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(6-(4-(3-(((3s,5s,7s)- adamantan-1- yl)amino)propyl)piperazin- 1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		4-(4-(3-(2,4-dioxocyclohexyl)- 2-methyl-4-oxo-3,4- dihydroquinazolin-5- yl)piperazin-1-yl)-3- fluorobenzonitrile
		3-(7-(4-(3-(((3s,5s,7s)- adamantan-1- yl)amino)propyl)piperazin- 1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(8-(4-(3-(((3s,5s,7s)- adamantan-1- yl)amino)propyl)piperazin- 1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(((2-((((3s, 5s,7s)-adamantan-1- yl)amino)methyl) cyclopropyl) methyl)amino)-2- methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
		3-(2-(8-(((3s,5s,7s)- adamantan-1- yl)amino)octyl)-5- fluoro-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
		3-(5-((7-(((1s,3s)- adamantan-1-yl)amino) heptyl)amino)- 2-(8-(((3s,5s,7s)- adamantan-1-yl) amino)octyl)-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-((2-(((1s, 3s)-adamantan-1- yl)amino)ethyl)thio)ethyl) amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
		3-(5-((5-(((1s,3s)- adamantan-1-yl)amino)-3- oxopentyl)amino)-2- methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
		3-(5-((5-(((1s,3s)- adamantan-1- yl)amino)-3,3- difluoropentyl)amino)- 2-methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
		3-(5-((5-(((1s,3s)- adamantan-1-yl)amino)-3- thioxopentyl)amino)-2- methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
		2-(((3s,5s,7s)-adamantan- 1-yl)amino)ethyl 3-((3-(2,6- dioxopiperidin-3-yl)- 2-methyl-4-oxo-3,4- dihydroquinazolin- 5-yl)amino)propanoate
		N-(4-(((3s,5s,7s)- adamantan-1-yl)(methyl) amino)butyl)- 3-((3-(2,6-dioxopiperidin- 3-yl)-2-methyl-4-oxo-3,4- dihydroquinazolin-5- yl)amino)propanamide
		3-(5-((2-((2-(((1s,3s)- adamantan-1- yl)amino)ethyl)amino) ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-((2-(((1s, 3s)-adamantan-1- yl)amino)ethyl)(methyl) amino)ethyl)amino)- 2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02663		3-(5-((7-hydroxyheptyl) oxy)-2-methyl- 4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02769		3-(5-((7-(((1s,3s)- adamantan-1-yl)amino) heptyl)oxy)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02770		3-(2-methyl-5-((7-(4- (oxetan-3-yl)piperazin-1- yl)heptyl)oxy)-4- oxoquinazolin-3(4H)- yl)piperidine-2,6- dione
GT- 02771		3-(2-methyl-5-((7-(4- methylpiperazin-1- yl)heptyl)oxy)-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((7-((1-((3r,5r, 7r)-adamantan-1- yl)ethyl)amino)heptyl) oxy)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		3-(5-((7-(((3as,6as)- hexahydro-2,5- methanopentalen- 3a(1H)-yl)amino)heptyl) oxy)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(5-((7-(((1s,3s)- adamantan-1-yl)amino) heptyl)oxy)-4- oxo-2-(trifluoromethyl) quinazolin-3(4H)- yl)piperidine- 2,6-dione
		3-(4-oxo-2-(trifluoromethyl)- 5-((7-(((1R,2S,4R)-1,7,7- trimethylbicyclo [2.2.1]heptan-2- yl)amino)heptyl)oxy) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(S)-3-(2-methyl-4-oxo- 5-((7-(((1R, 2S,4R)-1,7,7- trimethylbicyclo [2.2.1]heptan-2- yl)amino)heptyl)oxy) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(S)-3-(5-((7-((4- fluorobicyclo [2.2.2]octan-1- yl)amino)heptyl)oxy)- 2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		(3R)-3-(5-((7-(((1s, 3s)-adamantan-1- yl)amino)heptyl)oxy)- 2-methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
		(R)-3-(5-(2-(2-(2- (((3s,5s,7s)-adamantan-1- yl)amino)ethoxy)ethoxy) ethoxy)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		(S)-3-(5-((7-(((1SR, 3RS,5SR,7r)-3,5- dimethyladamantan- 1-yl)amino)heptyl) oxy)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		(S)-3-(5-((7-(((1SR, 3RS,5SR,7r)-3,5- dimethyladamantan- 1-yl)amino)heptyl) oxy)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(3S)-3-(5-((7-((1- ((3r,5r,7r)-adamantan-1- yl)ethyl)amino)heptyl) oxy)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(3R)-3-(5-((7- (((3as,6as)-hexahydro- 2,5-methanopentalen- 3a(1H)-yl)amino)heptyl) oxy)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(3R)-3-(5-((7-(((1s, 3s)-adamantan-1- yl)amino)heptyl) oxy)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(S)-3-(4-oxo-2- (trifluoromethyl)-5- ((7-(((1R,2S,4R)- 1,7,7-trimethylbicyclo [2.2.1]heptan-2- yl)amino)heptyl)oxy) quinazolin-3(4H)- yl)piperidine-2,6- dione
GT- 02802		3-(5-((7-(((1s,3s)- adamantan-1-yl) amino)heptyl)thio)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
		3-(5-((7-(((1SR,3RS, 5SR,7r)-3,5- dimethyladamantan-1- yl)amino)heptyl) thio)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		3-(5-((7-(((1s,3s)- adamantan-1- yl)amino)heptyl)thio)-4- oxo-2-(trifluoromethyl) quinazolin-3(4H)- yl)piperidine- 2,6-dione
		3-(4-oxo-2- (trifluoromethyl)-5-((7- (((1R,2S,4R)-1,7,7- trimethylbicyclo[2.2.1] heptan-2- yl)amino)heptyl)thio) quinazolin-3(4H)-yl) piperidine-2,6- dione
		(S)-3-(5-((7-(((1SR, 3RS,5SR,7r)-3,5- dimethyladamantan-1- yl)amino)heptyl) thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		(3S)-3-(5-((7-((1-((3r, 5r,7r)-adamantan-1- yl)ethyl)amino) heptyl)thio)-2-methyl- 4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
		(3R)-3-(5-((7-(((1s, 3s)-adamantan-1- yl)amino)heptyl)thio)- 2-methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
		(S)-3-(2-methyl-4-oxo- 5-((7-(((1R,2S,4R)-1,7,7- trimethylbicyclo [2.2.1]heptan-2- yl)amino)heptyl)thio) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(S)-3-(4-oxo-2- (trifluoromethyl)-5- ((7-(((1R,2S,4R)- 1,7,7-trimethylbicyclo [2.2.1]heptan-2- yl)amino)heptyl)thio) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(S)-3-(5-((7-((4- fluorobicyclo [2.2.2]octan-1- yl)amino)heptyl) thio)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
		(3R)-3-(5-((7-(((1s, 3s)-adamantan-1- yl)amino)heptyl) thio)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)-yl) piperidine-2,6- dione
		(S)-3-(5-((7-(((1SR, 3RS,5SR,7r)-3,5- dimethyladamantan-1- yl)amino)heptyl) thio)-4-oxo-2- (trifluoromethyl) quinazolin-3(4H)- yl)piperidine-2,6- dione
GT- 02814		3-(5-(3-(((3s,5s,7s)- adamantan-1-yl) amino)prop-1-yn-1- yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6- dione
GT- 02597		3-(5-(5-hydroxypent- 1-yn-1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02632		3-(5-(5-(((3s,5s,7s)- adamantan-1-yl)amino) pent-1-yn-1- yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6- dione
GT- 02633		3-(2-methyl-4-oxo-5- (5-(piperidin-1- yl)pent-1-yn-1- yl)quinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02634		3-(2-methyl-5-(5- (4-methylpiperazin- 1-yl)pent-1-yn-1- yl)-4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02635		3-(2-methyl-5-(5-(4- (oxetan-3-yl)piperazin- 1-yl)pent-1- yn-1-yl)-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02636		3-(2-methyl-5-(5-(4- methyl-1,4-diazepan- 1-yl)pent-1-yn- 1-yl)-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02815		3-(5-(5-(6-oxa-3- azabicyclo[3.1.1]heptan- 3-yl)pent-1-yn- 1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6- dione
GT- 02816		3-(2-methyl-5-(5-(4- (4-methylpiperazin- 1-yl)piperidin-1- yl)pent-1-yn-1-yl)- 4-oxoquinazolin-3(4H)- yl)piperidine- 2,6-dione
GT- 02817		3-(2-methyl-5-(5-(4- morpholinopiperidin- 1-yl)pent-1-yn- 1-yl)-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02818		3-(5-(5-((1-((1s,3s)- adamantan-1-yl)ethyl) amino)pent-1- yn-1-yl)-2-methyl-4- oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02637		3-(5-(8-hydroxyoct- 1-yn-1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02638		3-(5-(8-(((1s,3s)- adamantan-1-yl)amino) oct-1-yn-1-yl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02639		3-(2-methyl-5-(8-(4- (oxetan-3-yl)piperazin- 1-yl)oct-1-yn- 1-yl)-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02645		3-(2-methyl-5-(8-(4- methylpiperazin-1- yl)oct-1-yn-1-yl)- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02653		3-(2-methyl-5-(8-(4-(4- methylpiperazin-1- yl)piperidin-1- yl)oct-1-yn-1-yl)-4- oxoquinazolin-3(4H)- yl)piperidine- 2,6-dione
GT- 02654		3-(5-(8-(6-oxa-3- azabicyclo[3.1.1] heptan-3-yl)oct-1-yn- 1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6- dione
GT- 02640		3-(5-(5-hydroxypentyl)- 2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02759		3-(5-(5-(((3s,5s,7s)- adamantan-1- yl)amino)pentyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02761		3-(2-methyl-5-(5-(4- (oxetan-3-yl)piperazin- 1-yl)pentyl)- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02762		3-(5-(5-(6-oxa-3- azabicyclo[3.1.1]heptan- 3-yl)pentyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02763		3-(2-methyl-5-(5-(4- methylpiperazin-1-yl)pentyl)-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02764		3-(2-methyl-5-(5-(4-(4- methylpiperazin- 1-yl)piperidin-1- yl)pentyl)-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02760		3-(5-(8-hydroxyoctyl)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02797		3-(5-(8-(((1s,3s)-adamantan- 1-yl)amino)octyl)-2-methyl- 4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 02798		3-(2-methyl-5-(8-(4- (oxetan-3-yl)piperazin- 1-yl)octyl)-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02799		3-(2-methyl-5-(8-(4- (4-methylpiperazin- 1-yl)piperidin-1- yl)octyl)-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 02800		3-(5-(8-(6-oxa-3- azabicyclo[3.1.1] heptan-3-yl)octyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 02813		3-(2-methyl-5-(8- (4-methylpiperazin- 1-yl)octyl)-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(4-oxo-2-(trifluoromethyl)- 5-(8-(((1R,2S,4R)-1,7,7- trimethylbicyclo[2.2.1]heptan-2- yl)amino)octyl)quinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(4-oxo-2-(trifluoromethyl)- 5-(8-(((1R,2S,4R)-1,7,7- trimethylbicyclo[2.2.1]heptan- 2-yl)amino)oct-1-yn-1- yl)quinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(8-(((1s,3s)-adamantan-1- yl)amino)octyl)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(5-(8-(((1s,3s)- adamantan-1-yl)amino) oct-1-yn-1-yl)-4- oxo-2-(trifluoromethyl) quinazolin-3(4H)-yl)piperidine- 2,6-dione
		3-(5-(8-((1-((3r,5r, 7r)-adamantan-1- yl)ethyl)amino)octyl)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(5-(8-((1-((3r,5r,7r)-adamantan- 1-yl)ethyl)amino)oct-1- yn-1-yl)-4-oxo-2- (trifluoromethyl)quinazolin-3(4H)- yl)piperidine-2,6-dione
		(S)-3-(2-methyl-4-oxo- 5-(8-(((1R,2S,4R)-1,7,7- trimethylbicyclo[2.2.1]heptan-2- yl)amino)octyl)quinazolin- 3(4H)-yl)piperidine-2,6-dione
		(S)-3-(2-methyl-4-oxo- 5-(8-(((1R,2S,4R)-1,7,7- trimethylbicyclo[2.2.1] heptan-2-yl)amino)oct-1-yn-1- yl)quinazolin-3(4H)- yl)piperidine-2,6-dione
		(3R)-3-(5-(8- (((1s,3s)-adamantan-1- yl)amino)octyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		(3R)-3-(5-(8-(((1s,3s)- adamantan-1-yl)amino) oct-1-yn-1- yl)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6- dione
		(3R)-3-(5-(8-(((3as,6as)- hexahydro-2,5-methanopentalen- 3a(1H)-yl)amino)octyl)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		(3R)-3-(5-(8-(((3as, 6as)-hexahydro- 2,5-methanopentalen- 3a(1H)-yl)amino)oct- 1-yn-1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		(3S)-3-(5-(8-((1- ((3r,5r,7r)-adamantan-1- yl)ethyl)amino)octyl)- 2-methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
		(3S)-3-(5-(8-((1- ((3r,5r,7r)-adamantan-1- yl)ethyl)amino)oct- 1-yn-1-yl)-2-methyl- 4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		(S)-3-(5-(8-(((1SR, 3RS,5SR,7r)-3,5- dimethyladamantan- 1-yl)amino)octyl)-4-oxo- 2-(trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6-dione
		(S)-3-(5-(8- (((1SR,3RS,5SR,7r)- 3,5-dimethyladamantan- 1-yl)amino)oct-1-yn- 1-yl)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		(3S)-3-(5-(8-((1- ((3r,5r,7r)-adamantan-1- yl)ethyl)amino)octyl)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		(3S)-3-(5-(8-((1- ((3r,5r,7r)-adamantan-1- yl)ethyl)amino)oct-1- yn-1-yl)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		(3R)-3-(5-(8-(((1s,3s)- adamantan-1-yl)amino)octyl)-4- oxo-2-(trifluoromethyl) quinazolin-3(4H)-yl)piperidine- 2,6-dione
		(3R)-3-(5-(8-(((1s,3s)- adamantan-1-yl)amino)oct-1-yn-1- yl)-4-oxo-2- (trifluoromethyl)quinazolin-3(4H)- yl)piperidine-2,6-dione
		(3S)-3-(5-(8-((2-isopropyl-5- methylcyclohexyl) oxy)octyl)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		(3S)-3-(5-(8-((2-isopropyl-5- methylcyclohexyl)oxy)oct- 1-yn-1-yl)-4-oxo-2- (trifluoromethyl)quinazolin- 3(4H)- yl)piperidine-2,6-dione
		(S)-3-(4-oxo-2-(trifluoromethyl)- 5-(8-(((1R,2S,4R)-1,7,7- trimethylbicyclo[2.2.1]heptan-2- yl)amino)octyl)quinazolin- 3(4H)-yl)piperidine-2,6-dione
		(S)-3-(4-oxo-2-(trifluoromethyl)- 5-(8-(((1R,2S,4R)-1,7,7- trimethylbicyclo[2.2.1]heptan- 2-yl)amino)oct-1-yn-1- yl)quinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(6-(3-(((1s,3s)-adamantan- 1-yl)amino)prop-1-yn-1-yl)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(6-(3-(((1s,3s)-adamantan- 1-yl)amino)propyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(6-(5-(((1s,3s)-adamantan- 1-yl)amino)pent-1-yn-1-yl)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(6-(5-(((1s,3s)-adamantan- 1-yl)amino)pentyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(6-(8-(((3s,5s,7s)-adamantan- 1-yl)amino)oct-1-yn-1- yl)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(6-(8-(((3s,5s,7s)-adamantan- 1-yl)amino)octyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(6-(8-((1-((1s,3s)-adamantan- 1-yl)ethyl)amino)oct-1- yn-1-yl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine- 2,6-dione
		3-(6-(8-((1-((1s,3s)-adamantan- 1-yl)ethyl)amino)octyl)- 2-methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(7-(8-(((3s,5s,7s)-adamantan- 1-yl)amino)oct-1-yn-1- yl)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(7-(8-(((3s,5s,7s)-adamantan- 1-yl)amino)octyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(7-(8-(((3s,5s,7s)-adamantan- 1-yl)amino)octyl)-4-oxo- 2-(trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(8-(8-(((3s,5s,7s)-adamantan- 1-yl)amino)oct-1-yn-1- yl)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(8-(8-(((3s,5s,7s)-adamantan- 1-yl)amino)octyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(8-(8-(((3s,5s,7s)-adamantan- 1-yl)amino)octyl)-4-oxo- 2-(trifluoromethyl)quinazolin- 3(4H)-yl)piperidine-2,6- dione
		3-(5-(8-(((1s,3s)-adamantan- 1-yl)amino)octyl)-2-(8- (((3s,5s,7s)-adamantan- 1-yl)amino)octyl)-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT 02323		(3r,5r,7r)-N-(5-((3-(2,6- dioxopiperidin-3-yl)-2-methyl-4- oxo-3,4-dihydroquinazolin-5- yl)amino)pentyl)adamantane- 1-carboxamide
		N-((1s,3s)-adamantan- 1-yl)-7-((3-(2,6-dioxopiperidin-3- yl)-2-methyl-4-oxo- 3,4-dihydroquinazolin-5- yl)amino)heptanamide
		3-(5-((4-((((1s,3s)-adamantan-1- yl)amino)methyl)piperazin- 1-yl)methyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((4-(2-(((3s,5s,7s)-adamantan-1- yl)amino)ethyl)piperazin- 1-yl)methyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03226		3-(5-((4-(3-(((1s,3s)-adamantan-1- yl)amino)propyl)piperazin- 1-yl)methyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(2-(4-((((3s,5s, 7s)-adamantan-1- yl)amino)methyl) piperazin-1-yl)ethyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(2-(4-(2-(((1s, 3s)-adamantan-1- yl)amino)ethyl)piperazin- 1-yl)ethyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(2-(4-(3- (((3s,5s,7s)-adamantan-1- yl)amino)propyl)piperazin- 1-yl)ethyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-((((1s,3s)- adamantan-1- yl)amino)methyl)piperazin- 1-yl)propyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-(2- (((3s,5s,7s)-adamantan-1- yl)amino)ethyl)piperazin- 1-yl)propyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03227		3-(5-((4-(((3r,5r,7r)- adamantan-1-yl) methyl)piperazin-1- yl)methyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03228		3-(2-methyl-4-oxo-5- (piperazin-1-ylmethyl)quinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 03229		3-(2-methyl-4-oxo-5- (3-(piperazin-1-yl)prop-1-yn-1- yl)quinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03258		3-(5-((4-(7-(((1s,3s)- adamantan-1- yl)amino)heptyl) piperazin-1-yl)methyl)- 2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-(2- (((3s,5s,7s)-adamantan-1- yl)amino)ethyl)piperazin- 1-yl)prop-1-yn-1-yl)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-(3- (((1s,3s)-adamantan-1- yl)amino)propyl)piperazin- 1-yl)prop-1-yn-1-yl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 03231		3-(5-((2-(4-((1s,3s)- adamantan-1-yl)piperazin-1- yl)ethyl)thio)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03232		3-(5-((3-(4- ((3s,5s,7s)-adamantan- 1-yl)piperazin-1- yl)propyl)thio)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03284		3-(5-((2-(4-((1s,3s)- adamantan-1-yl)piperazin-1- yl)ethyl)amino)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(2-(4-((1s,3s)- adamantan-1-yl)piperazin-1- yl)ethoxy)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-((1s,3s)- adamantan-1-yl) piperazin-1-yl)prop- 1-yn-1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-((1s,3s)- adamantan-1-yl)piperazin-1- yl)propyl)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03259		3-(5-((2-(4- (((3r,5r,7r)-adamantan- 1-yl)methyl)piperazin- 1-yl)ethyl)thio)-2- methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
GT- 03235		3-(5-((3-(4-(((1s,3s)-adamantan- 1-yl)methyl)piperazin-1- yl)propyl)thio)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-(((3r,5r,7r)-adamantan- 1-yl)methyl)piperazin- 1-yl)ethyl)amino)- 2-methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(2-(4-(((3r,5r,7r)-adamantan- 1-yl)methyl)piperazin- 1-yl)ethoxy)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03302		3-(5-(3-(4-(((3r,5r,7r)-adamantan- 1-yl)methyl)piperazin- 1-yl)prop-1-yn-1-yl)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-(((3r,5r,7r)-adamantan- 1-yl)methyl)piperazin- 1-yl)propyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03305		3-(5-((2-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)piperazin- 1-yl)ethyl)thio)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03301		3-(5-((2-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)piperazin- 1-yl)ethyl)amino)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(2-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)piperazin- 1-yl)ethoxy)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)piperazin- 1-yl)prop-1-yn-1-yl)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)piperazin- 1-yl)propyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03230		3-(5-((4-(4-((3r,5r,7r)- adamantan-1-yl)benzyl)piperazin- 1-yl)methyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((4-(2-((1s,3s)- adamantan-1-yl)ethyl)piperazin-1- yl)methyl)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03233		3-(5-(3-(4-(4-((3r,5r, 7r)-adamantan-1- yl)benzyl)piperazin-1- yl)prop-1-yn-1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-(4-((3r,5r, 7r)-adamantan-1- yl)benzyl)piperazin-1- yl)propyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-((1s,3s)- adamantan-1-yl)piperazin-1-yl- 2,2,3,3,5,5,6,6-d8) ethyl)thio)-2-methyl- 4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-((2-(4-((1s,3s)- adamantan-1-yl)piperazin-1-yl- 2,2,3,3,5,5,6,6-d8)ethyl) amino)-2-methyl-4- oxoquinazolin-3(4H)-yl) piperidine-2,6-dione
		3-(5-(2-(4-((1s,3s)- adamantan-1-yl)piperazin-1-yl- 2,2,3,3,5,5,6,6-d8) ethoxy)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-(3-(4-(((3r,5r,7r)- adamantan-1-yl)methyl)piperazin- 1-yl-2,2,3,3,5,5,6,6-d8) prop-1-yn-1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-(2-((1s,3s)- adamantan-1-yl)ethyl)piperazin-1- yl-2,2,3,3,5,5,6,6-d8) prop-1-yn-1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(3-(4-(2-((1s,3s)- adamantan-1-yl)ethyl)piperazin-1- yl-2,2,3,3,5,5,6,6-d8) propyl)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-(((1-((((1s,3s)-adamantan-1- yl)amino)methyl) cyclopropyl)methyl) amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((4-(2-(((2R,3as, 5S,6as)-hexahydro-2,5- methanopentalen-3a(1H)- yl)amino)ethyl)piperazin-1- yl)methyl)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((4-(3-(((3as,6as)- hexahydro-2,5-methanopentalen- 3a(1H)-yl)amino)propyl) piperazin-1-yl)methyl)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-((2-((2-(((1s,3s)-adamantan-1- yl)amino)ethyl)(methyl) amino)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		N-((3s,5s,7s)-adamantan- 1-yl)-2-((3-(2,6-dioxopiperidin- 3-yl)-2-methyl-4-oxo- 3,4-dihydroquinazolin-5- yl)amino)ethane-1-sulfonamide
		N-((1s,3s)-adamantan- 1-yl)-1-(1-(3-(2,6-dioxopiperidin- 3-yl)-2-methyl-4-oxo- 3,4-dihydroquinazolin-5- yl)piperidin-3- yl)methanesulfonamide
		N-((3s,5s,7s)-adamantan- 1-yl)-2-((3-(2,6-dioxopiperidin- 3-yl)-2-methyl-4-oxo- 3,4-dihydroquinazolin-5- yl)thio)ethane-1-sulfonamide
		N-((3s,5s,7s)-adamantan- 1-yl)-2-((3-(2,6-dioxopiperidin- 3-yl)-2-methyl-4-oxo- 3,4-dihydroquinazolin-5- yl)oxy)ethane-1-sulfonamide
		N-((3s,5s,7s)-adamantan- 1-yl)-3-(3-(2,6-dioxopiperidin- 3-yl)-2-methyl-4- oxo-3,4-dihydroquinazolin-5- yl)propane-1-sulfonamide
		N-((3s,5s,7s)-adamantan- 1-yl)-3-((3-(2,6-dioxopiperidin- 3-yl)-2-methyl-4-oxo- 3,4-dihydroquinazolin-5- yl)amino)propane-1-sulfonamide
		3-(2-methyl-5-((4- ((4-(oxetan-3-yl)piperazin-1- yl)sulfonyl)butyl)amino)- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-(((3s,5s, 7s)-adamantan-1-yl) amino)-1H-1,2,3- triazol-1-yl)propyl) amino)-2-methyl- 4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
GT- 03388		3-(8-((2-(4-(bis(4- fluorophenyl)methyl) piperazin-1- yl)ethyl)amino)-3- methyl-1-oxoisoquinolin- 2(1H)- yl)piperidine-2,6-dione
GT- 03306		3-(5-((3-(4-(2-((3r, 5r,7r)-adamantan-1- yl)ethyl)piperazin- 1-yl)propyl)thio)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03384		3-(5-((3-(4- benzhydrylpiperazin-1- yl)propyl)thio)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 03387		3-(5-((3-(4-(bis(4- fluorophenyl)methyl) piperazin-1- yl)propyl)thio)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03697		3-(5-((3-(4-(bis(4- chlorophenyl)methyl) piperazin-1- yl)propyl)thio)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(6-((3-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)piperazin- 1-yl)propyl)thio)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(7-((3-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)piperazin- 1-yl)propyl)thio)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(8-((3-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)piperazin- 1-yl)propyl)thio)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(6-((2-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)piperazin- 1-yl)ethyl)amino)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(7-((2-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)piperazin- 1-yl)ethyl)amino)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(8-((2-(4-(2- ((3r,5r,7r)-adamantan-1- yl)ethyl)piperazin- 1-yl)ethyl)amino)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 04231		3-(5-(3-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-3,6- diazabicyclo[3.1.1]heptan- 6-yl)-2-methyl-4- oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 04230		3-(5-(6-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-3,6- diazabicyclo[3.1.1]heptan- 3-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 04253		3-(5-(3-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-3,8- diazabicyclo[3.2.1]octan- 8-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03727		3-(5-(8-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-3,8- diazabicyclo[3.2.1]octan- 3-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 04228		3-(5-(5-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-2,5- diazabicyclo[2.2.2]octan- 2-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 04232		3-(5-((1S,4S)-5-(2- ((3S,5S,7S)-adamantan-1-yl)ethyl)- 2,5-diazabicyclo[2.2.1] heptan-2-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 04233		3-(5-((1R,4R)-5-(2- ((3R,5R,7R)-adamantan-1-yl)ethyl)- 2,5-diazabicyclo [2.2.1]heptan-2-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 04246		3-(5-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-3,5- dimethylpiperazin-1- yl)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-2,6- dimethylpiperazin-1- yl)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-2- (trifluoromethyl)piperazin- 1-yl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-2- (fluoromethyl)piperazin- 1-yl)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-2,2- dimethylpiperazin-1-yl)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 04229		3-(5-(4-(2-((3r,5r,7r)- adamantan-1-yl)ethyl)-1,4- diazepan-1-yl)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-(2-((3r, 5r,7r)-adamantan- 1-yl)ethyl)-3,5- dimethylpiperazin- 1-yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-(2-((3r,5r, 7r)-adamantan-1-yl)ethyl)-2,6- dimethylpiperazin-1- yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)-2- (trifluoromethyl)piperazin- 1-yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)-2- (fluoromethyl)piperazin- 1-yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-(2-((3r, 5r,7r)-adamantan- 1-yl)ethyl)-2,2- dimethylpiperazin- 1-yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)-1,4- diazepan-1-yl)propyl) thio)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-((2-(3-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)-3,6- diazabicyclo[3.1.1]heptan- 6-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(6-(2-((3r, 5r,7r)-adamantan- 1-yl)ethyl)-3,6- diazabicyclo[3.1.1]heptan- 3-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(3-(2-((3r, 5r,7r)-adamantan-1-yl)ethyl)-3,8- diazabicyclo[3.2.1]octan- 8-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(8-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)-3,8- diazabicyclo[3.2.1]octan- 3-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(5-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)-2,5- diazabicyclo[2.2.2]octan- 2-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-((1S,4S)- 5-(2-((3S,5S,7S)- adamantan-1- yl)ethyl)-2,5-diazabicyclo [2.2.1]heptan-2- yl)ethyl)amino)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-((1R,4R)- 5-(2-((3R,5R,7R)-adamantan-1- yl)ethyl)-2,5- diazabicyclo[2.2.1]heptan-2- yl)ethyl)amino)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-(2-((3r, 5r,7r)-adamantan-1- yl)ethyl)-3,5- dimethylpiperazin-1- yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)-2,6- dimethylpiperazin-1- yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)-3- (trifluoromethyl)piperazin- 1-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)-2- (fluoromethyl)piperazin- 1-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-(2- ((3r,5r,7r)-adamantan- 1-yl)ethyl)-2,2- dimethylpiperazin- 1-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-(2-((3r, 5r,7r)-adamantan- 1-yl)ethyl)-1,4- diazepan-1-yl)ethyl) amino)-2-methyl-4- oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
GT- 03385		3-(5-((2-(4- benzhydrylpiperazin-1- yl)ethyl)amino)-2- methyl-4-oxoquinazolin- 3(4H)-yl)piperidine- 2,6-dione
		3-(5-((2-(4-((4′-chloro- 5,5-dimethyl-3,4, 5,6-tetrahydro- [1,1′-biphenyl]-2- yl)methyl)piperazin- 1-yl)ethyl)amino)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-((2-(4-((4′- chloro-[1,1′-biphenyl]-2- yl)methyl)piperazin- 1-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-((4′- fluoro-5,5-dimethyl- 3,4,5,6-tetrahydro- [1,1′-biphenyl]-2-yl) methyl)piperazin- 1-yl)ethyl)amino)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-((2-(4-((4′-fluoro- 3,4,5,6-tetrahydro-[1,1′-biphenyl]- 2-yl)methyl)piperazin- 1-yl)ethyl)amino)-2-methyl-4- oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-((2-(4-((4′- chloro-4-methoxy- 4-methyl-3,4,5,6- tetrahydro-[1,1′-biphenyl]- 2-yl)methyl)piperazin-1- yl)ethyl)amino)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-((4′- chloro-4,4-dimethyl- 3,4,5,6-tetrahydro- [1,1′-biphenyl]-2- yl)methyl)piperazin- 1-yl)ethyl)amino)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-((2-(4-((4-(4- chlorophenyl)-5,6- dihydro-2H-pyran- 3-yl)methyl)piperazin- 1-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-((4- (4-chlorophenyl)- 6,6-dimethyl-5,6- dihydro-2H-pyran-3- yl)methyl)piperazin-1- yl)ethyl)amino)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-((4′- chloro-4,4-difluoro- 3,4,5,6-tetrahydro- [1,1′-biphenyl]-2- yl)methyl)piperazin- 1-yl)ethyl)amino)- 2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-((8-(4- chlorophenyl)spiro [4.5]dec-7-en-7- yl)methyl)piperazin- 1-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((2-(4-((6-(4- chlorophenyl)spiro [3.5]non-6-en-7- yl)methyl)piperazin- 1-yl)ethyl)amino)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-((4′- chloro-5,5-dimethyl- 3,4,5,6-tetrahydro- [1,1′-biphenyl]-2- yl)methyl)piperazin- 1-yl)propyl)thio)- 2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-((4′- chloro-[1,1′-biphenyl]-2- yl)methyl)piperazin- 1-yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-((4′- fluoro-5,5-dimethyl- 3,4,5,6-tetrahydro- [1,1′-biphenyl]-2- yl)methyl)piperazin- 1-yl)propyl)thio)- 2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-((4′-fluoro- 3,4,5,6-tetrahydro- [1,1′-biphenyl]- 2-yl)methyl)piperazin- 1-yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-((4′- chloro-4-methoxy- 4-methyl-3,4,5,6- tetrahydro-[1,1′-biphenyl]- 2-yl)methyl)piperazin-1- yl)propyl)thio)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-((4′- chloro-4,4-dimethyl- 3,4,5,6-tetrahydro- [1,1′-biphenyl]-2- yl)methyl)piperazin- 1-yl)propyl)thio)- 2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione
		3-(5-((3-(4-((4-(4- chlorophenyl)-5,6- dihydro-2H-pyran- 3-yl)methyl)piperazin- 1-yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-((4-(4- chlorophenyl)- 6,6-dimethyl-5,6- dihydro-2H-pyran- 3-yl)methyl)piperazin-1- yl)propyl)thio)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-((4′- chloro-4,4-difluoro- 3,4,5,6-tetrahydro- [1,1′-biphenyl]-2- yl)methyl)piperazin- 1-yl)propyl)thio)- 2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-((8-(4- chlorophenyl)spiro [4.5]dec-7-en-7- yl)methyl)piperazin- 1-yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
		3-(5-((3-(4-((6-(4- chlorophenyl)spiro [3.5]non-6-en-7- yl)methyl)piperazin- 1-yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03314		4-(4-(2-((3-(2,6- dioxopiperidin-3- yl)-2-methyl-4-oxo-3,4- dihydroquinazolin-5- yl)thio)ethyl)piperazin-1-yl)-3- fluorobenzonitrile
GT- 03315		3-(5-((2-(4-(4-((1s, 3s)-adamantan-1-yl) benzyl)piperazin- 1-yl)ethyl)thio)-2- methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03285		3-(5-((2-(4-(((1s,3s)- adamantan-1-yl) methyl)piperazin-1- yl)ethyl)amino)-2- methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03316		3-(5-((2-(4-(4-((1s, 3s)-adamantan-1-yl) benzyl)piperazin- 1-yl)ethyl)amino)-2- methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
GT- 03313		4-(4-(2-((3-(2,6- dioxopiperidin-3-yl)- 2-methyl-4-oxo-3,4- dihydroquinazolin-5-yl) amino)ethyl) piperazin-1-yl)-3- fluorobenzonitrile
GT- 03310		3-(5-(2-(4-((3s,5s,7s)- adamantan-1-yl)piperazin-1- yl)ethoxy)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03311		3-(5-(2-(4-(4-((1s,3s)- adamantan-1-yl) benzyl)piperazin- 1-yl)ethoxy)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03312		4-(4-(2-((3-(2,6-dioxopiperidin- 3-yl)-2-methyl-4-oxo-3,4- dihydroquinazolin-5- yl)oxy)ethyl)piperazin-1-yl)-3- fluorobenzonitrile
GT- 03261		3-(5-((4-(2-((3r,5r,7r)- adamantan-1-yl) ethyl)piperazin-1- yl)methyl)-2-methyl- 4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03317		3-(5-((4-((1s,3s)-adamantane- 1-carbonyl)piperazin-1- yl)methyl)-2-methyl-4- oxoquinazolin-3(4H)- yl)piperidine-2,6-dione
GT- 03262		3-(5-(3-(4-(2-((1s,3s)- adamantan-1-yl) ethyl)piperazin-1- yl)prop-1-yn-1-yl)-2- methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione
GT- 03318		3-(5-(3-(4-((3r,5r,7r)- adamantane-1- carbonyl)piperazin- 1-yl)prop-1-yn-1-yl)- 2-methyl-4-oxoquinazolin- 3(4H)- yl)piperidine-2,6-dione

II. Other Forms of Compounds (Including Salts, Enantiomers, Stereoisomers, Solvates, Isotopically Enriched Analogs, Prodrugs, or Polymorphs of Compounds)

The compounds of the present disclosure have the structures of any one of Formula (I), Formula (I-1), Formula (I-2), Formula (I-3), Formula (I-4), Formula (I-5), Formula (I-6), Formula (I-7), Formula (I-8), Formula (II), Formula (II), Formula (III), Formula (Ia), Formula (Ib), Formula (Ic), Formula (Id), Formula (IIa), Formula (IIb), Formula (IIc), Formula (IId), Formula (IIIa), Formula (IIb), Formula (IIIc), or Formula (IIId). Unless otherwise specified, all references to the compounds of the present disclosure also include compounds of any one of Formula (I), Formula (I-1), Formula (I-2), Formula (I-3), Formula (I-4), Formula (I-5), Formula (I-6), Formula (I-7), Formula (I-8), Formula (II), Formula (II), Formula (III), Formula (Ia), Formula (Ib), Formula (Ic), Formula (Id), Formula (IIa), Formula (IIb), Formula (IIc), Formula (IId), Formula (IIa), Formula (IIIb), Formula (IIIc), or Formula (IIId) and specific compounds within the scope of these general formulae.

It should be recognized that compounds of the present disclosure (including compounds of Formula (I), Formula (I-1), Formula (I-2), Formula (I-3), Formula (I-4), Formula (I-5), Formula (I-6), Formula (I-7), Formula (I-8), Formula (II), Formula (II), Formula (III), Formula (IIa), Formula (Ib), Formula (Ic), Formula (Id), Formula (IIa), Formula (IIb), Formula (IIc), Formula (IId), Formula (IIIa), Formula (IIIb), Formula (IIIc), or Formula (IIId)) may have a stereo-configuration and thus can exist in more than one stereoisomeric form. The present disclosure also relates to optically enriched compounds having a stereo-configuration, e.g., greater than about 90% enantiomeric/diastereomeric excess (“ee”), such as about 95% ee or 97% ee, or greater than 99% ee, and mixtures thereof, including racemic mixtures. As used herein, “optically enriched” means that a mixture of enantiomers consists of a significantly greater proportion of one enantiomer, and can be described by enantiomeric excess (ee %). Purification of isomers and separation of mixtures of isomers can be accomplished by standard techniques known in the art (e.g., column chromatography, preparative TLC, preparative HPLC, asymmetric synthesis (e.g., by using chiral intermediates) and/or or chiral resolution, etc.).

In some embodiments, polymorph forms or salts of the compounds of the present disclosure are also provided. Salts of the compounds of the present disclosure can be pharmaceutically acceptable salts including, but not limited to, hydrochlorides, sulfates, citrates, maleates, sulfonates, citrates, lactates, tartrates, fumarates, phosphates, dihydrophosphates, pyrophosphates, metaphosphates, oxalates, malonates, benzoates, mandelates, succinates, trifluoroacetates, hydroxyacetates, or p-toluenesulfonates, etc. The compounds of the present disclosure can exist as non-solvated or solvated forms in pharmaceutically acceptable solvents such as water, ethanol, and the like. In some embodiments, compounds of the present disclosure can be prepared as prodrugs or precursor drugs.

Prodrugs can be converted into parent drugs in the body to play their role. In some embodiments, isotopically-labeled compounds of the present disclosure are also provided, examples of which include deuterium (D or ²H).

III. Compositions/Formulations

In some embodiments, the present disclosure provides a pharmaceutical composition comprising as an active ingredient the compound of the present disclosure or a pharmaceutically acceptable salt, solvate, isotopically enriched analog, polymorph, prodrug, stereoisomer (including enantiomer), or mixture of stereoisomers thereof, and at least one pharmaceutically acceptable carrier.

In some embodiments, pharmaceutically acceptable carriers include, but are not limited to, fillers, stabilizers, dispersants, suspending agents, diluents, excipients, thickeners, colorants, solvents, or encapsulating materials. Each carrier must be “acceptable” in the sense of being compatible with the other ingredients of the formulation (including the compounds useful in the present disclosure) and not injurious to the patient. Some examples of materials that can be used as pharmaceutically acceptable carriers include: sugars such as lactose, glucose, and sucrose; starches such as corn starch and potato starch; cellulose and its derivatives such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt; gelatin; talc; excipients such as cocoa butter and suppository wax; oils such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols such as propylene glycol; polyols such as glycerol, sorbitol, mannitol, and polyethylene glycol; esters such as ethyl oleate and ethyl laurate; agar; buffers such as magnesium hydroxide and aluminum hydroxide; surfactant phosphate buffer solution; polyethylene oxide, polyvinylpyrrolidone, polyacrylamide, poloxamer; and other common non-toxic compatible substances used in pharmaceutical formulations.

The pharmaceutical composition of the present disclosure can further comprise at least one second therapeutic agent, e.g., an anticancer agent. The second therapeutic agent may be used in combination with the compounds of Formula (I) described in the present disclosure to treat the diseases or disorders as disclosed herein. The second therapeutic agent includes, but is not limited to, chemotherapeutic agents, immunotherapeutic agents, gene therapy agents, and the like.

The pharmaceutical composition of the present disclosure comprising, as an active ingredient, the compounds of Formula (I) of the present disclosure or a pharmaceutically acceptable salt thereof can be formulated into any suitable formulations such as sprays, patches, tablets (such as conventional tablets, dispersible tablets, orally disintegrating tablets), capsules (such as soft capsules, hard capsules, enteric-coated capsules), dragees, troches, powders, granules, powder injections, suppositories, or liquid formulations (such as suspensions (e.g., aqueous or oily suspensions), solutions, emulsions, or syrups), or conventional injection dosage forms such as injectable solutions (e.g., sterile injectable solutions formulated according to methods known in the art using water, Ringer's solution, or isotonic sodium chloride solution or the like as a vehicle or solvent) or lyophilized injectable formulation and the like, depending upon a suitable route of administration (including, but not limited to, nasal administration, inhalation administration, topical administration, oral administration, oral mucosal administration, rectal administration, intrapleural administration, intraperitoneal administration, vaginal administration, intramuscular administration, subcutaneous administration, transdermal administration, epidural administration, intrathecal administration, and intravenous administration).

Those skilled in the art can also formulate the compounds of Formula (I) of the present disclosure into conventional, dispersible, chewable, orally disintegrating or rapidly dissolving formulations, or sustained-release capsules or controlled-release capsules as needed.

The compounds of Formula (I) of the present disclosure, as an active ingredient, is contained in the pharmaceutically acceptable carrier or diluent in an amount sufficient to deliver to a subject a therapeutically effective amount for the indication to be treated, without causing serious toxic effects in the subject treated. A dosage of the active compound for all diseases or disorders mentioned herein ranges, for example, from about 5 ng/kg to 500 mg/kg, from about 10 ng/kg to 300 mg/kg per day, such as from 0.1 to 100 mg/kg, or from 0.5 to about 25 mg per kilogram body weight of the subject per day.

The compounds of Formula (I) of the present disclosure or pharmaceutically acceptable salts thereof can be conveniently administered in any suitable unit dosage form. Suitable unit dosage form specifications include, but are not limited to, less than 1 mg, 1 mg to 3000 mg, 5 mg to 1000 mg, for example, 5 to 500 mg, 25 to 250 mg of active ingredient per unit dosage form.

IV. Kits/Packaged Products

The compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, isotopically enriched analog, polymorph, prodrug, stereoisomer (including enantiomer), or mixture of stereoisomers thereof is used as a medicament. The medicament of the present disclosure or the pharmaceutical composition of the present disclosure may be presented in a kit/packaged product. The kit/packaged product may include a package or container including, but not limited to, ampoules, blister packs, pharmaceutical plastic bottles, vials, pharmaceutical glass bottles, containers, syringes, laminated flexible packaging, co-extruded film infusion containers, test tubes and dispensing devices, and the like. The kit/packaged product may contain instructions for use of the product.

V. Methods and Uses

The compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, isotopically enriched analog, polymorph, prodrug, stereoisomer (including enantiomer), or mixture of stereoisomers thereof can be used as a medicament. Especially the compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, isotopically enriched analog, polymorph, prodrug, stereoisomer (including enantiomer), or mixture of stereoisomers thereof can be used for the manufacture of a medicament for the prevention and/or treatment of diseases or disorders associated with cereblon protein. The diseases or disorders associated with cereblon protein comprise: tumor, infectious disease, inflammatory disease, autoimmune disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, cardiovascular disease, Richter syndrome (RS), acute liver failure, or diabetes. In some embodiments, the diseases or disorders associated with cereblon protein include, but are not limited to, myeloma, including multiple myeloma, plasma cell myeloma, smoldering myeloma, smoldering multiple myeloma; myelofibrosis; bone marrow disease; myelodysplastic syndrome (MDS); previously treated myelodysplastic syndrome; transplantation-related cancer; neutropenia; leukemia, including acute myeloid leukemia, chronic myelogenous leukemia, B-cell chronic lymphocytic leukemia, leukemia-associated anemia, acute myeloid leukemia (AML); lymphoma, including diffuse large B-cell lymphoma, non-Hodgkin's lymphoma, Hodgkin's lymphoma, anaplastic lymphoma, anaplastic large cell lymphoma, CD20 positive lymphoma, mantle cell lymphoma, primary lymphoma, B-cell lymphoma, recurrent B-cell non-Hodgkin's lymphoma, recurrent diffuse large B-cell lymphoma, recurrent mediastinal (thymic) large B-cell lymphoma, primary mediastinal (thymic) large B-cell lymphoma, recurrent transformed non-Hodgkin's lymphoma, refractory B-cell non-Hodgkin's lymphoma, refractory diffuse large B-cell lymphoma, refractory primary mediastinal (thymic) large B-cell lymphoma, refractory transformed non-Hodgkin's lymphoma; thyroid cancer; melanoma; lung cancer, including lung adenocarcinoma, lung squamous cell carcinoma; inflammatory myofibroblastoma; colorectal cancer; intestinal cancer; brain glioma; astroblastoma; ovarian cancer; bronchial cancer; prostate cancer; breast cancer, including triple negative breast cancer, sporadic breast cancer and patients with Cowden syndrome; pancreatic cancer; central nervous system tumor; neuroblastoma; neuroglioma; Peripheral neuroepithelioma; extramedullary plasmacytoma; plasmacytoma; gastric cancer; gastrointestinal stromal tumors; esophageal cancer; colorectal adenocarcinoma; esophageal squamous cell carcinoma; liver cancer; renal cell carcinoma; bladder cancer; endometrial cancer; metrocarcinoma; head and neck cancer; brain cancer; oral cancer; sarcoma, including rhabdomyosarcoma, various lipogenic tumors, Ewing's sarcoma/primitive neuroectodermal tumors (Ewing/PNETs), and leiomyosarcoma; urothelial carcinoma; basal cell carcinoma; oral squamous cell carcinoma; cholangiocarcinoma; bone cancer; cervical cancer; skin cancer; Richter syndrome (RS); sepsis syndrome; autoimmune diseases, including rheumatoid arthritis, autoimmune encephalomyelitis, ankylosing spondylitis, psoriasis, systemic lupus erythematosus, multiple sclerosis, recurrent oral ulcers, Kawasaki disease, polymyositis/dermatomyositis, Sjogren's syndrome, and atopic dermatitis; keratoconjunctivitis; inflammatory diseases, including Crohn's disease and ulcerative colitis, pneumonia, osteoarthritis, synovitis, systemic inflammatory response syndrome, airway inflammation, bronchitis; cerebral malaria; infectious diseases, including viral pneumonia, Acquired immunodeficiency syndrome (AIDS), COVID-19 novel coronavirus infection, gram-negative bacteria infection, gram-positive bacteria infection, tuberculosis, etc.; septic shock; tuberculosis; bacterial meningitis; chronic obstructive pulmonary disease; asthma; hemorrhagic shock; organ (including kidney, heart, lung) or tissue transplantation rejection; diabetes; sarcoidosis; adult respiratory distress syndrome; anemia; pediatric aplastic anemia; cardiovascular diseases (e.g., coronary heart disease, congestive heart failure, myocardial infarction, atherosclerosis); multiple organ dysfunction caused by cachexia and septic shock; or acute liver failure.

The present disclosure provides a method for preventing and/or treating diseases or disorders associated with cereblon protein in a subject, comprising administering to the subject a therapeutically effective amount of the compounds of Formula (I) of the present disclosure or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition of the present disclosure comprising as an active ingredient the compounds of Formula (I) of the present disclosure or a pharmaceutically acceptable salt thereof. In some embodiments, the diseases or disorders associated with cereblon protein comprise: tumor, infectious disease, inflammatory disease, autoimmune disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, cardiovascular disease, Richter syndrome (RS), acute liver failure, or diabetes. In some embodiments, the diseases or disorders associated with cereblon protein include, but are not limited to, myeloma, including multiple myeloma, plasma cell myeloma, smoldering myeloma, smoldering multiple myeloma; myelofibrosis; bone marrow disease; myelodysplastic syndrome (MDS); previously treated myelodysplastic syndrome; transplantation-related cancer; neutropenia; leukemia, including acute myeloid leukemia, chronic myelogenous leukemia, B-cell chronic lymphocytic leukemia, leukemia-associated anemia, acute myeloid leukemia (AML); lymphoma, including diffuse large B-cell lymphoma, non-Hodgkin's lymphoma, Hodgkin's lymphoma, anaplastic lymphoma, anaplastic large cell lymphoma, CD20 positive lymphoma, mantle cell lymphoma, primary lymphoma, B-cell lymphoma, recurrent B-cell non-Hodgkin's lymphoma, recurrent diffuse large B-cell lymphoma, recurrent mediastinal (thymic) large B-cell lymphoma, primary mediastinal (thymic) large B-cell lymphoma, recurrent transformed non-Hodgkin's lymphoma, refractory B-cell non-Hodgkin's lymphoma, refractory diffuse large B-cell lymphoma, refractory primary mediastinal (thymic) large B-cell lymphoma, refractory transformed non-Hodgkin's lymphoma; thyroid cancer; melanoma; lung cancer, including lung adenocarcinoma, lung squamous cell carcinoma; inflammatory myofibroblastoma; colorectal cancer; intestinal cancer; brain glioma; astroblastoma; ovarian cancer; bronchial cancer; prostate cancer; breast cancer, including triple negative breast cancer, sporadic breast cancer and patients with Cowden syndrome; pancreatic cancer; central nervous system tumor; neuroblastoma; neuroglioma; Peripheral neuroepithelioma; extramedullary plasmacytoma; plasmacytoma; gastric cancer; gastrointestinal stromal tumors; esophageal cancer; colorectal adenocarcinoma; esophageal squamous cell carcinoma; liver cancer; renal cell carcinoma; bladder cancer; endometrial cancer; metrocarcinoma; head and neck cancer; brain cancer; oral cancer; sarcoma, including rhabdomyosarcoma, various lipogenic tumors, Ewing's sarcoma/primitive neuroectodermal tumors (Ewing/PNETs), and leiomyosarcoma; urothelial carcinoma; basal cell carcinoma; oral squamous cell carcinoma; cholangiocarcinoma; bone cancer; cervical cancer; skin cancer; Richter syndrome (RS); sepsis syndrome; autoimmune diseases, including rheumatoid arthritis, autoimmune encephalomyelitis, ankylosing spondylitis, psoriasis, systemic lupus erythematosus, multiple sclerosis, recurrent oral ulcers, Kawasaki disease, polymyositis/dermatomyositis, Sjogren's syndrome, and atopic dermatitis; keratoconjunctivitis; inflammatory diseases, including Crohn's disease and ulcerative colitis, pneumonia, osteoarthritis, synovitis, systemic inflammatory response syndrome, airway inflammation, bronchitis; cerebral malaria; infectious diseases, including viral pneumonia, Acquired immunodeficiency syndrome (AIDS), COVID-19 novel coronavirus infection, gram-negative bacteria infection, gram-positive bacteria infection, tuberculosis, etc.; septic shock; tuberculosis; bacterial meningitis; chronic obstructive pulmonary disease; asthma; hemorrhagic shock; organ (including kidney, heart, lung) or tissue transplantation rejection; diabetes; sarcoidosis; adult respiratory distress syndrome; anemia; pediatric aplastic anemia; cardiovascular diseases (e.g., coronary heart disease, congestive heart failure, myocardial infarction, atherosclerosis); multiple organ dysfunction caused by cachexia and septic shock; or acute liver failure.

In the method for preventing and/or treating diseases or disorders associated with cereblon protein in a subject, the compound of Formula (I) of the present disclosure or the pharmaceutical composition comprising as an active ingredient the compound of Formula (I) of the present disclosure of the present disclosure is administered to the subject through at least one mode of administration selected from the group consisting of nasal administration, inhalation administration, topical administration, oral administration, oral mucosal administration, rectal administration, pleural cavity administration, peritoneal administration, vaginal administration, intramuscular administration, subcutaneous, transdermal, epidural, intrathecal, and intravenous administration.

The term “treatment” or “treating” refers to the administration of the compound of Formula (I) or a pharmaceutically acceptable salt thereof according to the present disclosure, or the pharmaceutical composition containing, as an active ingredient, the compound of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject to mitigate (alleviate) undesirable diseases or conditions, such as the development of a cancer or tumor. The beneficial or desired clinical results of the present disclosure include, but are not limited to: alleviating symptoms, reducing the severity of the disease, stabilizing the state of the disease, slowing down or delaying the progression of the disease, improving or alleviating the condition, and alleviating the disease.

A “therapeutic effective amount” of the compound of the present disclosure depends on a variety of factors, including the activity of the specific compound used, the metabolic stability of the compound and the duration of its action, the age, sex and weight of the patient, the patient's current medical condition, the route and duration of administration, the excretion rate, the combined administration of additional drugs, and the progression of the diseases or conditions of the patient being treated. Those skilled in the art will be able to determine appropriate dosages based on these and other factors.

It is to be understood that the choice of using one or more active compounds and/or compositions and their dosage depends on the basic situations of the individual (which should generally render the individual situation to achieve the best effect). Dosing and dosing regimens should be within the ability of those skilled in the art, and the appropriate dosage depends on many factors including the knowledge and ability of the physicians, veterinarians or researchers (see e.g., Jun Li (chief editor), “Clinical Pharmacology”, 4th edition, People's Public Health Press, 2008).

As used herein, the term “patient” or “subject” to be treated refers to animal, for example mammal, including but not limited to primate (such as human being), cow, sheep, goat, horse, dog, cat, rabbit, guinea pig, rat, mice, etc.

VI. Definitions

Unless otherwise specified, the following words, phrases and symbols used herein generally have the meanings as described below.

In general, the nomenclature used herein (including the IUPAC nomenclature) and the laboratory procedures described below (including those used in cell culture, organic chemistry, analytical chemistry, and pharmacology, etc.) are those well-known and commonly used in the art.

Unless otherwise defined, all scientific and technical terms used herein in connection with the present disclosure described herein have the same meaning as commonly understood by one skill in the art. In addition, the use of the word “a” or “an” when used in conjunction with the term “comprising” or a noun in the claims and/or the specification may mean “one”, but it is also consistent with the meaning of “one or more”, “at least one”, and “one or more than one”. Similarly, the terms “another” or “other” can mean at least a second or more.

It should be understood that whenever the term “comprise” or “include” is used herein to describe various aspects, other similar aspects described by “consisting of” and/or “consisting essentially of” are also provided.

As used herein, the term “about” used alone or in combination refers to approximately, roughly, nearly, or around. When the term “about” is used in conjunction with a numerical range, it modifies that range by extending the boundaries above and below the stated numerical value. In general, the term “about” can modify a numerical value above and below the stated value by an upward or downward (increasing or decreasing) variation, e.g., 10%, 5%, 2%, or 1%.

As used herein, the wording “ . . . represents a bond” used alone or in combination means that the referenced group is a bond linker (that is, the referenced group is absent). For example, the wording “X₂ represents a bond” means that X₂ is a bond linker. In other words, when X₂ represents a bond, the group R_a1 in the structure of Formula (I) is directly connected to L₁ in the structure of Formula (I). For example, the wording “X₁ represents a bond” means that X₁ is a bond linker. In other words, when X₁ represents a bond, the group L₁ in the structure of Formula (I) is directly connected to quinazoline ring in the structure of Formula (I).

In this document, the term “optionally substituted” used alone or in combination means that the referenced group may be unsubstituted or substituted with one or more substituents as defined here.

Herein, the wording “optionally substituted with . . . ” and “unsubstituted or substituted” can be used interchangeably. The term “substituted” generally indicates that one or more hydrogens in the referenced structure are replaced by the same or different specific substituents. The number of substituents is not theoretically limited in any way, or is automatically limited by the size of the building units (i.e., the total number of replaceable hydrogen atoms in the building units), or as clearly defined herein.

As used herein, the term “inserted” of the expression “one or more groups R_d1 and/or one or more groups R_d2 and/or any combination of one or more groups R_d1 and R_d2 are inserted into the backbone carbon chain of the linear or branched C_2-60 alkylene group”, used alone or in combination, has a known definition in the art, which can mean that carbon-carbon bond between one or more pairs of adjacent carbon atoms in the referenced backbone carbon chain is interrupted by the groups R_d1, R_d2, or a combination of R_d1 and R_d2. Herein, examples of the above-mentioned expression “one or more groups . . . are inserted into” may include, but are not limited to, that one or more (1-30, 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_d1 as defined herein and/or one or more (1-30, 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R_d2 as defined herein and/or one or more (1-30, 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) combinations of R_d1 with R_d2 are inserted into the backbone carbon chain, and the resulting backbone chain group conforms to the covalent bond theory. For example, the expression “one or more groups R_e2 and/or one or more groups R_e3 and/or any combination of one or more groups R_e2 and R_e3 are inserted into the backbone carbon chain of the linear or branched C_2-30 alkylene group” can refer to that one or more (e.g., 1-30, 1-20, 1-15, 1-10, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2 or 1) groups R_e2 and/or R_e3 and/or any combination of one or more groups R_e2 with R_e3 are inserted between one or more pairs of any two adjacent carbon atoms of the backbone carbon chain of the linear or branched C_2-30 alkylene group, resulting in the formation of a backbone chain group containing one or more (e.g., 1-30, 1-20, 1-15, 1-10, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2 or 1) fragments “—CH₂—R_e2—CH₂—” and/or one or more (e.g., 1-30, 1-20, 1-15, 1-10, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2 or 1) fragments “—CH₂—R_e3—CH₂—” and/or one or more (e.g., 1-30, 1-20, 1-15, 1-10, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2 or 1) fragments “—CH₂—R_e2—R_e3—CH₂—”, where each R_e2 are the same or different, each R_e3 are the same or different, and are as defined herein.

Herein, it should be understood that the expression “one or more groups R_e2 and/or one or more groups R_e3 or any combination of one or more groups R_e2 and R_e3 are optionally inserted into the backbone carbon chain of the linear or branched C_2-30 alkylene group” includes embodiments where “one or more groups R_e2 and/or one or more groups R_e3 or any combination of one or more groups R_e2 and R_e3 are inserted into the backbone carbon chain of the linear or branched C_2-30 alkylene group”, as well as embodiments where “none of one or more groups R_e2 and/or one or more groups R_e3 or any combination of one or more groups R_e2 and R_e3 are inserted into the backbone carbon chain of the linear or branched C_2-30 alkylene group”.

Herein, a bond interrupted by a wavy line shows the point of attachment of the depicted group to the rest of the molecule. For example, the group R_a1 depicted below

• • shows the point of attachment of R_f1 in said group to X₂. For example, the group R_f1 depicted below:

symbol * indicates the point of attachment of the atom N to X₂, while ring A is connected to the methylene group of R_a1. Herein, when the attachment point of the group is not specified, e.g., for the group —(CH₂)₆—C(O)—(CH₂)₁— represented by L₂, either end of the group (e.g., (CH₂)₁) can be attached to the quinazoline ring of the compound of Formula (I), while the other end is attached to X₄.

As used herein, the expression “a hydrogen atom of one or more CH₂ of the linear or branched C_x-y alkylene is replaced with . . . ”, used alone or in combination, means that a hydrogen atom of any one or more CH₂ of the linear or branched C_x-y alkylene is replaced by a substituent(s) as defined herein. Herein, the term “one or more” of “a hydrogen atom of one or more CH₂ of groups —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₆—, —(CH₂)₇—, —(CH₂)₈—, —(CH₂)₉—, —(CH₂)₁₀—, —(CH₂)₁₁—, —(CH₂)₁₂—, —(CH₂)₁₃—, —(CH₂)₁₄—, —(CH₂)₁₅—, —(CH₂)₁₆—, —(CH₂)₁₇—, —(CH₂)₁₈—, —(CH₂)₁₉—, —(CH₂)₂₀—, —(CH₂)₂₁—, —(CH₂)₂₂—, —(CH₂)₂₅—, or —(CH₂)₃₀—” may refer to part or all hydrogen atoms of each referenced alkylene group, including but not limited to 1-60 hydrogens. In some embodiments, the expression “a hydrogen atom of one or more CH₂” may refer to part or all of the hydrogen atoms of the referenced alkylene group, including but not limited to 1-30, such as 1-25, 1-20, 1-15, 1-10, 1-5, 1-4, 1-3, 1-2 or 1 hydrogen atoms. In some embodiments, the expression “a hydrogen atom of one or more CH₂” may include 1-3 of the plurality of hydrogen atoms of the referenced alkylene group. The number of hydrogens to be replaced is in principle not limited in any way, or is automatically limited by the size of the building unit.

As used herein, the term “halogen atom” or “halogen”, used alone or in combination, refers to fluorine, chlorine, bromine, or iodine.

As used herein, the term “alkyl”, used alone or in combination, refers to a linear or branched alkyl group. The term “C_x-C_y alkyl” or “C_x-y alkyl” (x and y each being an integer) refers to a linear or branched alkyl group containing from x to y carbon atoms. The term “C_1-60 alkyl” used alone or in combination in the present disclosure refers to a linear or branched alkyl group containing from 1 to 60 carbon atoms, examples of which include C₁-C₆₀ alkyl, C₁-C₄₀ alkyl, and C₁-C₃₀ alkyl and the like. The term “C_1-30 alkyl” used alone or in combination in the present disclosure refers to a linear or branched alkyl group containing from 1 to 30 carbon atoms. Examples of the C_1-60 alkyl of the present disclosure may include a C₁-C₄₀ alkyl, C₁-C₃₀ alkyl, C₁-C₂₉ alkyl, C₁-C₂₈ alkyl, C₁-C₂₇ alkyl, C₁-C₂₆ alkyl, C₁-C₂₅ alkyl, C₁-C₂₄ alkyl, C₁-C₂₃ alkyl, C₁-C₂₂ alkyl, C₁-C₂₁ alkyl, C₁-C₂₀ alkyl, C₁-C₁₉ alkyl, C₁-C₁₈ alkyl, C₁-C₁₇ alkyl, C₁-C₁₆ alkyl, C₁-C₁₅ alkyl, C₁-C₁₄ alkyl, C₁-C₁₃ alkyl, C₁-C₁₂ alkyl, C₁-C₁₁ alkyl, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₈ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, and C₁-C₂ alkyl. The term “C_1-10 alkyl” used alone or in combination in the present disclosure refers to a linear or branched alkyl group containing from 1 to 10 carbon atoms. Examples of the C_1-10 alkyl of the present disclosure may include a C_1-9 alkyl, C_1-8 alkyl, C_2-8 alkyl, C_1-7 alkyl, C_1-6 alkyl, C_1-5 alkyl, C_1-4 alkyl, and C_1-3 alkyl. Representative examples include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl, and decyl.

The term “C_1-3 alkyl” or “C₁-C₃ alkyl” in the present disclosure refers to an alkyl group containing from 1 to 3 carbon atoms, and representative examples of which include methyl, ethyl, n-propyl, and isopropyl. In the present disclosure, the “alkyl” is optionally substituted with one or more substituents optionally selected from the group consisting of halogen, hydroxy, cyano, C_1-3 alkyl, C_1-3 alkoxy, trifluoromethyl, heterocyclyl, or a combination thereof.

As used herein, the term “halogenated alkyl” or “haloalkyl”, used alone or in combination, refers to a linear or branched alkyl group substituted with one or more halogens, wherein one or more hydrogen atom(s) of the alkyl group are replaced with one or more halogens. The term “halogenated C_x-Cy alkyl” or “halogenated C_x-y alkyl” (x and y are each an integer) refers to a linear or branched alkyl containing from x to y carbon atoms substituted with one or more halogens. The term “halogenated C_1-10 alkyl” used alone or in combination in the present invention refers to a linear or branched alkyl group containing from 1 to 10 carbon atoms substituted with one or more halogens. Examples of the halogenated C_1-10 alkyl group of the present disclosure include halogenated C_1-9 alkyl group, e.g., halogenated C_1-8 alkyl group, halogenated C_2-8 alkyl group, halogenated C_1-7 alkyl group, halogenated C_1-6 alkyl, halogenated C_1-5 alkyl, or halogenated C_1-4 alkyl. Representative examples include halomethyl, haloethyl, halo-n-propyl, haloisopropyl, halo-n-butyl, haloisobutyl, halo-sec-butyl, halo-tert-butyl, halopentyl, haloisoamyl, haloneopentyl, halo-tert-pentyl, halohexyl, haloheptyl, halooctyl, halononyl, and halodecyl. The term “halo-C_1-3 alkyl” or “halo-C₁-C₃ alkyl” of the present disclosure refers to an alkyl group containing from 1 to 3 carbon atoms substituted with one or more halogens, and its representative examples include halomethyl, haloethyl, halo-n-propyl and haloisopropyl.

As used herein, the term “deuterated alkyl”, used alone or in combination, refers to a linear or branched alkyl group substituted with one or more deuterium atoms, wherein one or more hydrogen atom(s) of the alkyl group are replaced with one or more deuterium atoms. The term “deuterated C_x-Cy alkyl” or “deuterated C_x-y alkyl” (x and y are each an integer) refers to a linear or branched alkyl containing from x to y carbon atoms substituted with one or more deuterium atoms. The term “deuterated C_1-10 alkyl” used alone or in combination in the present invention refers to a linear or branched alkyl group containing from 1 to 10 carbon atoms substituted with one or more deuterium atoms. Examples of the deuterated C_1-10 alkyl group of the present disclosure include deuterated C₁_9 alkyl group, e.g., deuterated C_1-8 alkyl group, deuterated C_2-s alkyl group, deuterated C_1-7 alkyl group, deuterated C_1-6 alkyl, deuterated C_1-5 alkyl, or deuterated C_1-4 alkyl. Representative examples include perdeuterated methyl (CD₃), perdeuterated ethyl (CD₃CD₂), perdeuterated n-propyl, perdeuterated isopropyl, perdeuterated n-butyl, perdeuterated isobutyl, perdeuterated sec-butyl, perdeuterated tert-butyl, perdeuterated pentyl, perdeuterated isopentyl, perdeuterated neopentyl, perdeuterated tert-pentyl, perdeuterated hexyl, perdeuterated heptyl, perdeuterated octyl, perdeuterated nonyl, and perdeuterated decyl. The term “deuterated C_1-3 alkyl” or “deuterated C₁-C₃ alkyl” of the present disclosure refers to an alkyl group containing from 1 to 3 carbon atoms substituted with one or more deuterium atoms, and its representative examples include perdeuterated methyl (CD₃) and perdeuterated ethyl (CD₃CD₂).

As used herein, the term “alkylene” (which is used interchangeably with “alkylene chain”), used alone or in combination, refers to a linear or branched divalent saturated hydrocarbon group composed of carbon and hydrogen atoms. The term “C_x-C_y alkylene” or “C_x-y alkylene” (x and y each being an integer) refers to a linear or branched alkylene group containing from x to y carbon atoms.

The term “C₁-C₆₀ alkylene” or “C_1-60 alkylene” refers to a linear or branched alkylene group containing from 1 to 60 carbon atoms, examples of which include C₁-C₆₀ alkylene, C₁-C₄₀ alkylene, and C₁-C₃₀ alkylene and the like. Examples of the C₁-C₃₀ alkylene in the present disclosure may include C₁-C₃₀ alkylene, C₁-C₂₉ alkylene, C₁-C₂₈ alkylene, C₁-C₂₇ alkylene, C₁-C₂₆ alkylene, C₁-C₂₅ alkylene, C₁-C₂₄ alkylene, C₁-C₂₃ alkylene, C₁-C₂₂ alkylene, C₁-C₂₁ alkylene, C₁-C₂₀ alkylene, C₁-C₁₉ alkylene, C₁-C₁₈ alkylene, C₁-C₁₇ alkylene, C₁-C₁₆ alkylene, C₁-C₁₅ alkylene, C₁-C₁₄ alkylene, C₁-C₁₃ alkylene, C₁-C₁₂ alkylene, C₁-C₁₁ alkylene, C₁-C₁₀ alkylene, C₁-C₉ alkylene, C₁-C₈ alkylene, C₁-C₇ alkylene, C₁-C₆ alkylene, C₁-C₅ alkylene, C₁-C₄ alkylene, C₁-C₃ alkylene, or C₁-C₂ alkylene. Representative examples include, but are not limited to, methylene, ethylene, propylene, isopropylene, butylene, isobutylene, sec-butylene, tert-butylene, n-pentylene, isopentylene, neopentylidene, tert-pentylene, hexylene, heptylene, octylene, nonylene, decylene, undecylene, dodecylene, tridecylene, tetradecylene, pentadecylene, hexadecylene, heptadecylene, octadecylene, nonadecylene, eicosylene, heneicosylene, docosylene, tricosylene, tetracosylene, pentacosylene, hexacosylene, heptacosylene, octacosylene, nonacosylene, and triacontylene. In the present disclosure, the “alkylene” is optionally substituted with one or more substituents optionally selected from C_1-3 alkyl, C_3-6 cycloalkyl, hydroxyl, amino, mercapto, halogen, C_1-3 alkoxy, C_1-3 alkylamino, halogenated C_1-3 alkyl, amino-substituted C_1-3 alkylene, C_1-3 alkyl-NHC(O)—, C_1-3 alkyl-C(O)NH—, cyano, or any combination thereof.

As used herein, the term “alkoxy”, used alone or in combination, refers to a linear or branched alkoxy group having structural formula of —O-alkyl. Optionally, the alkyl portion of the alkoxy group may contain 1-10 carbon atoms. Representative examples of “alkoxy” include, but are not limited to, methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, tert-butoxy, pentyloxy, 2-pentyloxy, isopentyloxy, neopentyloxy, hexyloxy, 2-hexyloxy, 3-hexyloxy, 3-methylpentyloxy, etc. The term “C₁-C₃ alkoxy” or “C_1-3 alkoxy” refers to a linear or branched alkoxy group containing from 1 to 3 carbon atoms. Representative examples of C_1-3 alkoxy include, but are not limited to, methoxy, ethoxy, n-propoxy, and isopropoxy.

As used herein, the term “halogenated alkoxy”, used alone or in combination, refers to a alkoxy group substituted with one or more halogen atoms. Optionally, the alkyl portion of the alkoxy group may contain 1-10 carbon atoms. Examples of “halogenated alkoxy” include, but are not limited to, halogenated C_1-6 alkoxy or halogenated C_1-4 alkoxy. Representative examples include, but are not limited to, F₃C—O—, FCH₂—O—, F₂CH—O—, ClCH₂—O—, Cl₂CH—O—, CF₃CF₂—O—, CF₃CHF—O—, CHF₂CF₂—O—, CHF₂CHF—O—, CF₃CH₂—O— or CH₂ClCH₂—O—.

As used herein, the term “alkylamino”, used alone or in combination, refers to a linear or branched alkyl-NH—, wherein alkyl is as defined above. Optionally, the alkyl portion of the alkylamino group may contain 1-10 carbon atoms, i.e., C_1-10 alkyl-NH—. Representative examples of “alkylamino” include, but are not limited to, methyl-NH—, ethyl-NH—, n-propyl-NH—, isopropyl-NH—, n-butyl-NH—, isobutyl-NH—, tert-butyl-NH—, pentyl-NH—, and hexyl-NH—, etc. The term “C₁-C₃ alkyl-NH—” or “C_1-3 alkyl-NH—” refers to a linear or branched alkyl-NH— group containing from 1 to 3 carbon atoms. Representative examples of C_1-3 alkyl-NH— include, but are not limited to, methyl-NH—, ethyl-NH—, n-propyl-NH—, and isopropyl-NH—.

As used herein, the term “NH₂-alkylene”, used alone or in combination, refers to a linear or branched alkylene group substituted with amino, wherein alkyl is as defined above. Optionally, the alkylene portion of the “NH₂-alkylene” group may contain 1-10 carbon atoms. The term “NH₂—C_1-3 alkylene” or “amino-C_1-3 alkylene-” refers to a linear or branched alkylene group containing from 1 to 3 carbon atoms which is substituted with amino. Representative examples of NH₂—C_1-3 alkylene include, but are not limited to, NH₂—CH₂—, NH₂—CH₂CH₂—, and NH₂—CH₂CH₂CH₂—.

As used herein, the term “alkyl-NHC(O)—”, used alone or in combination, refers to a linear or branched alkyl-NHC(O)— group, wherein alkyl is as defined above. Optionally, the alkyl portion of the alkyl-NHC(O)— group may contain 1-10 carbon atoms. The term “C_1-3 alkyl-NHC(O)—” or “C₁-C₃ alkyl-NHC(O)—” refers to a linear or branched alkyl-NHC(O)— group containing from 1 to 3 carbon atoms.

Representative examples of C_1-3 alkyl-NHC(O)— include, but are not limited to, CH₃—NHC(O)—, CH₃CH₂—NHC(O)—, and CH₃CH₂CH₂—NHC(O)—.

As used herein, the term “alkyl-C(O)NH—”, used alone or in combination, refers to a linear or branched alkyl-C(O)NH— group, wherein alkyl is as defined above. Optionally, the alkyl portion of the alkyl-C(O)NH— group may contain 1-10 carbon atoms. The term “C_1-3 alkyl-C(O)NH—” or “C₁-C₃ alkyl-C(O)NH—” refers to a linear or branched alkyl-C(O)NH— group containing from 1 to 3 carbon atoms. Representative examples of C_1-3 alkyl-C(O)NH— include, but are not limited to, CH₃—C(O)NH—, CH₃CH₂—C(O)NH—, and CH₃CH₂CH₂—C(O)NH—.

As used herein, the term “heteroaryl”, used alone or in combination, refers to a 5- to 20-membered (e.g., 5- to 15-membered, 5- to 12-membered, 5- to 11-membered, 5- to 10-membered, 5- to 9-membered, 5- to 8-membered, 5- to 7-membered, 5- to 6-membered, 6- to 15-membered, or 6- to 9-membered) monocyclic, bicyclic, or polycyclic cyclic aromatic ring radical containing one or more (e.g., from 1 to 6, or from 1 to 5, or from 1 to 4, or from 1 to 3) heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur. Bicyclic or polycyclic heteroaryl groups include bicyclic, tricyclic or tetracyclic heteroaryl groups, which contain one aromatic ring having one or more heteroatoms independently selected from O, S and N, and the remaining rings which may be a saturated, partially unsaturated or aromatic ring and can be carbocyclic ring or contain one or more heteroatoms independently selected from O, S and N. Examples of monocyclic heteroaryl groups include, but are not limited to, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, tetrazolyl, and triazinyl. Examples of bicyclic heteroaryl groups include, but are not limited to, indolyl, isoindolyl, isoindolinyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, oxazolopyridyl, furopyridyl, pteridyl, purinyl, pyridopyridyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl. Examples of tricyclic heteroaryl groups include, but are not limited to, acridinyl, benzindolyl, carbazolyl, dibenzofuranyl, and xanthyl. The heteroaryl group may be unsubstituted or substituted. A substituted heteroaryl refers to heteroaryl substituted one or more times (e.g., 1-4, 1-3, or 1-2 times) by a substituent(s) optionally selected from the group consisting of C_1-3 alkyl, C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-3 alkoxy, C_1-3 alkylamino, halogenated C_1-3 alkyl, amino-substituted C_1-3 alkylene, C_1-3 alkyl-NHC(O)—, C_1-3 alkyl-C(O)NH—, cyano, or any combination thereof.

As used herein, the term “heteroarylene”, used alone or in combination, refers to a 5- to 20-membered (e.g., 5- to 15-membered, 5- to 12-membered, 5- to 11-membered, 5- to 10-membered, 5- to 9-membered, 5- to 8-membered, 5- to 7-membered, 5- to 6-membered, 6- to 15-membered, or 6- to 9-membered) bivalent monocyclic, bicyclic, or polycyclic cyclic aromatic ring radical containing one or more (e.g., from 1 to 6, or from 1 to 5, or from 1 to 4, or from 1 to 3) heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur. Bicyclic or polycyclic heteroarylene groups include bicyclic, tricyclic or tetracyclic heteroarylene groups, which contain one aromatic ring having one or more heteroatoms independently selected from O, S and N, and the remaining ring(s) which may be a saturated, partially unsaturated or aromatic ring and can be carbocyclic ring or contain one or more heteroatoms independently selected from O, S and N. Examples of monocyclic heteroarylene groups include, but are not limited to, furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, tetrazolylene, and triazinylene. Examples of bicyclic heteroarylene groups include, but are not limited to, indolylene, isoindolylene, isoindolinylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, oxazolopyridylene, furopyridylene, pteridylene, purinylene, pyridopyridylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, pyrrolo[2,1-b]thiazolylene, and imidazo[2,1-b]thiazolylene. Examples of tricyclic heteroarylene groups include, but are not limited to, acridinylene, benzindolylene, carbazolylene, dibenzofuranylene, and xanthylene. The heteroarylene group may be unsubstituted or substituted. A substituted heteroarylene refers to heteroarylene substituted one or more times (e.g., 1-4, 1-3, or 1-2 times) by a substituent(s) optionally selected from the group consisting of C_1-3 alkyl, C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-3 alkoxy, C_1-3 alkylamino, halogenated C_1-3 alkyl, amino-substituted C_1-3 alkylene, C_1-3 alkyl-NHC(O)—, C_1-3 alkyl-C(O)NH—, cyano, or any combination thereof.

As used herein, the term “aryl”, used alone or in combination, refers to a monovalent aromatic hydrocarbon group containing from 5 to 14 carbon atoms and optionally one or more fused rings, such as phenyl group, naphthyl group, or fluorenyl group. As used herein, the “aryl” is optionally substituted. A substituted aryl group refers to an aryl group substituted one or more times (e.g., 1-4, 1-3, or 1-2 times) with a substituent(s). For example, aryl is mono-, di-, or tri-substituted with a substituent(s) optionally selected from e.g., C_1-3 alkyl, C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-3 alkoxy, C_1-3 alkylamino, halogenated C_1-3 alkyl, amino-substituted C_1-3 alkylene, C_1-3 alkyl-NHC(O)—, C_1-3 alkyl-C(O)NH—, cyano, or any combination thereof.

As used herein, the term “arylene”, used alone or in combination, refers to a divalent aromatic hydrocarbon group containing from 5 to 14 carbon atoms and optionally one or more fused rings, such as phenylene, naphthylene, or fluorenylene. As used herein, the “arylene” is optionally substituted. A substituted arylene refers to an arylene group optionally substituted one or more times (e.g., 1-4, 1-3, or 1-2 times) with a substituent(s). For example, arylene is mono-, di-, or tri-substituted with a substituent(s) optionally selected from e.g., C_1-3 alkyl, C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-3 alkoxy, C_1-3 alkylamino, halogenated C_1-3 alkyl, amino-substituted C_1-3 alkylene, C_1-3 alkyl-NHC(O)—, C_1-3 alkyl-C(O)NH—, cyano, or any combination thereof.

As used herein, the term “cycloalkyl”, used alone or in combination, refers to a saturated or partially unsaturated (i.e., containing one or more double bonds, but not having a fully conjugated π-electron system) monocyclic or bicyclic or polycyclic cyclic hydrocarbon radical, which in some embodiments contains from 3 to 20 carbon atoms (i.e., C_3-20 cycloalkyl), or from 3 to 15 carbon atoms (i.e., C_3-15 cycloalkyl), or from 3 to 12 carbon atoms (i.e., C_3-12 cycloalkyl), or from 3 to 11 carbon atoms (i.e., C_3-11 cycloalkyl), or from 3 to 10 carbon atoms (i.e., C_3-10 cycloalkyl), or from 3 to 8 carbon atoms (i.e., C_3-8 cycloalkyl), or from 3 to 7 carbon atoms (i.e., C_3-7 cycloalkyl), or from 3 to 6 carbon atoms (i.e., C_3-6 cycloalkyl). The term “cycloalkyl” includes monocyclic, bicyclic, or tricyclic cyclic hydrocarbon radical having from 3 to 20 carbon atoms. Representative examples of monocyclic cycloalkyl groups include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, and cyclooctyl. Bicyclic and tricyclic cycloalkyl groups include bridged cycloalkyl (e.g., C_5-15 bridged cycloalkyl), fused cycloalkyl and spiro-cycloalkyl groups (e.g., C_5-15 spiro-cycloalkyl) such as, but not limited to, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro-cycloalkyl (e.g., C_5-11 spiro-cycloalkyl), adamantanyl, noradamantanyl, bornyl, norbornyl (also named as bicyclo[2.2.1]heptyl by the IUPAC system). As used herein, the “cycloalkyl” is optionally mono- or poly-substituted, such as, but not limited to, 2,2-, 2,3-, 2,4-, 2,5-, or 2,6-disubstituted cyclohexyl. The substituents of the substituted “cycloalkyl” can be optionally one or more (e.g., 1-5, 1-4, 1-3, 1-2, or 1) substituents selected from C_1-3 alkyl, C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-3 alkoxy, C_1-3 alkylamino, halogenated C_1-3 alkyl, amino-substituted C_1-3 alkylene, C_1-3 alkyl-NHC(O)—, C_1-3 alkyl-C(O)NH—, cyano, or any combination thereof. Examples of “C_3-6 cycloalkyl” include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, and cyclohexyl.

As used herein, the term “cycloalkylene”, used alone or in combination, refers to a saturated or partially unsaturated (i.e., containing one or more double bonds, but not having a fully conjugated π-electron system) monocyclic or bicyclic or polycyclic divalent cyclic hydrocarbon radical containing from 3 to 12 carbon atoms (e.g., 3-12, 3-11, 3-10, 3-8, 3-7, 3-6 carbon atoms). The term “cycloalkylene” includes monocyclic, bicyclic or tricyclic cycloalkylene having from 3 to 12 carbon atoms.

Representative examples of monocyclic cycloalkylene groups include, but are not limited to, cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, and cyclooctylene. Bicyclic and tricyclic cycloalkylene groups include bridged cycloalkylene (e.g., C_5-15 bridged cycloalkylene), fused cycloalkylene and spiro-cycloalkylene groups (e.g., C_5-15 spiro-cycloalkylene) such as, but not limited to, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, 2,3-dihydro-1H-indenylene, spiro-cycloalkylene (e.g., C_5-11 spiro-cycloalkylene), adamantanylene, noradamantanylene, and norbornylene (also named as bicyclo[2.2.1]heptylene by the IUPAC system). As used herein, the “cycloalkylene” is optionally mono- or poly-substituted, such as, but not limited to, 2,2-, 2,3-, 2,4-, 2,5-, or 2,6-disubstituted cyclohexylene. The substituents of the substituted “cycloalkylene” can be optionally one or more substituents selected from C_1-3 alkyl, C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-3 alkoxy, C_1-3 alkylamino, halogenated C_1-3 alkyl, amino-substituted C_1-3 alkylene, C_1-3 alkyl-NHC(O)—, C_1-3 alkyl-C(O)NH—, cyano, or any combination thereof.

As used herein, the term “C_x-y spiro-cycloalkyl” (x and y each being an integer), used alone or in combination, refers to a spiro-cycloalkyl group containing from x to y carbon atoms. As used herein, the term “C_7-11 spiro-cycloalkyl”, used alone or in combination, refers to a spiro-cycloalkyl group containing from 7 to 11 carbon atoms (e.g., 7-10, 7-9 carbon atoms). The term “C_5-15 spiro-cycloalkyl” includes “C_7-15 spiro-cycloalkyl” and “C_5-11 spiro-cycloalkyl”. Representative examples of “C_7-11 spiro-cycloalkyl” include, but are not limited to, spiro[3.3]heptyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, or spiro[5.5]undecyl. Herein, the term “C_x-y spiro-cycloalkyl” is optionally substituted. The “C_x-y spiro-cycloalkyl” is optionally further substituted with one or more (e.g., 1-10, 1-8, 1-6, 1-4, 1-3 or 1-2) substituents selected from the group consisting of C_1-3 alkyl, C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-3 alkoxy, C_1-3 alkylamino, halogenated C_1-3 alkyl, amino-substituted C_1-3 alkylene, C_1-3 alkyl-NHC(O)—, C_1-3 alkyl-C(O)NH—, cyano, or any combination thereof.

As used herein, the term “C_x-y spiro-cycloalkylene” (x and y each being an integer), used alone or in combination, refers to a spiro-cycloalkylene group containing from x to y carbon atoms. As used herein, the term “C_7-11 spiro-cycloalkylene”, used alone or in combination, refers to a spiro-cycloalkylene group containing from 7 to 11 carbon atoms (e.g., 7-10, 7-9 carbon atoms). The term “C_5-15 spiro-cycloalkylene” includes “C_7-15 spiro-cycloalkylene” and “C_5-11 spiro-cycloalkylene”. Representative examples of “C_7-15 spiro-cycloalkylene” include, but are not limited to, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, or spiro[5.5]undecylene. Herein, the term “C_x-y spiro-cycloalkylene” is optionally substituted. The “C_x-y spiro-cycloalkylene” is optionally further substituted with one or more (e.g., 1-10, 1-8, 1-6, 1-4, 1-3 or 1-2) substituents selected from the group consisting of C_1-3 alkyl, C_3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C_1-3 alkoxy, C_1-3 alkylamino, halogenated C_1-3 alkyl, amino-substituted C_1-3 alkylene, C_1-3 alkyl-NHC(O)—, C_1-3 alkyl-C(O)NH—, cyano, or any combination thereof.

As used herein, the term “C_x-y bridged cycloalkyl” (x and y each being an integer), used alone or in combination, refers to a bridged cycloalkyl group containing from x to y carbon atoms. As used herein, the term “C_5-15 bridged cycloalkyl”, used alone or in combination, refers to a bridged cycloalkyl group containing from 5 to 15 carbon atoms, examples of which include “C_7-15 bridged cycloalkyl” and “C_5-11 bridged cycloalkyl”. Representative examples of “C_5-15 bridged cycloalkyl” include, but are not limited to, adamantanyl, noradamantanyl, norbornyl (also named as bicyclo[2.2.1]heptyl by the IUPAC system), and cubanyl. Herein, the term “C_x-y bridged cycloalkyl” is optionally substituted. The “C_x-y bridged cycloalkyl” is optionally further substituted with one or more (e.g., 1-10, 1-8, 1-6, 1-4, 1-3 or 1-2) substituents selected from the group consisting of C_1-3 alkyl, deuterated C_1-3 alkyl, C_1-3 alkoxy, halogen, halogenated C_1-3 alkyl, C_1-3 alkylamino, amino, hydroxy, cyano, oxo, or any combination thereof.

As used herein, the term “C_x-y bridged cycloalkylene” (x and y each being an integer), used alone or in combination, refers to a bridged cycloalkylene group containing from x to y carbon atoms. As used herein, the term “C_5-15 bridged cycloalkylene”, used alone or in combination, refers to a bridged cycloalkylene group containing from 5 to 15 carbon atoms, examples of which include “C_7-15 bridged cycloalkylene” and “C_5-11 bridged cycloalkylene”. Representative examples of “C_5-15 bridged cycloalkylene” include, but are not limited to, adamantanylene, noradamantanylene, norbornylene (also named as bicyclo[2.2.1]heptylene by the IUPAC system), and cubanylene. Herein, the term “C_x-y bridged cycloalkylene” is optionally substituted. The “C_x-y bridged cycloalkylene” is optionally further substituted with one or more (e.g., 1-10, 1-8, 1-6, 1-4, 1-3 or 1-2) substituents selected from the group consisting of C_1-3 alkyl, deuterated C_1-3 alkyl, C_1-3 alkoxy, halogen, halogenated C_1-3 alkyl, C_1-3 alkylamino, amino, hydroxy, cyano, oxo, or any combination thereof.

As used herein, the term “heterocyclyl” or “heterocyclic group”, used alone or in combination, refers to a 3- to 20-membered saturated or partially unsaturated (i.e., containing one or more double bonds, but not having a fully conjugated π-electron system) monocyclic, bicyclic, or tricyclic cyclic hydrocarbon group containing one or more (e.g., from 1 to 5, or from 1 to 4, from 1 to 3, from 1 to 2, or 1) heteroatoms independently selected from sulfur, oxygen, and nitrogen. In some embodiments, “heterocyclyl” may refer to a 3- to 15-membered (e.g., 3- to 14-membered, 3- to 12-membered, 3- to 11-membered, 3- to 10-membered, 3- to 9-membered, 3- to 8-membered, 3- to 7-membered, 3- to 6-membered, 3- to 5-membered, or 4- to 9-membered) saturated or partially unsaturated (i.e., containing one or more double bonds, but not having a fully conjugated π-electron system) monocyclic cyclic hydrocarbon group containing one or more (e.g., from 1 to 5, or from 1 to 4, from 1 to 3, from 1 to 2, or 1) heteroatoms independently selected from sulfur, oxygen, and nitrogen. Representative examples of the monocyclic heterocyclyl include, but are not limited to, azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl) and diazacyclooctyl. Bicyclic and tricyclic heterocyclyl groups include bridged heterocyclyl, fused heterocyclyl and spiro-heterocyclyl groups such as, but not limited to, 6-azabicyclo[3.1.1]heptan-3-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 3,6-diazabicyclo[3.1.1]heptan-3-yl, 3-azabicyclo[3.2.1]octan-8-yl, 3,8-diazabicyclo[3.2.1]octan-8-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, and azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecan-3-yl). The heterocyclyl may be unsubstituted or substituted as explicitly defined (e.g., mono-, di-, tri-, or poly-substituted) by a substituent(s) optionally selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl, halogenated C_1-6 alkyl, optionally deuterated C_3-6 cycloalkyl, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH— or any combination thereof.

As used herein, the term “nitrogen-containing monocyclic heterocyclyl”, used alone or in combination, refers to 3- to 20-membered (e.g., 3- to 15-membered, 3- to 14-membered, 3- to 12-membered, 3- to 11-membered, 3- to 10-membered, 3- to 9-membered, 3- to 8-membered, 3- to 7-membered, 3- to 6-membered, 3- to 5-membered, or 4- to 9-membered) saturated or partially unsaturated (i.e., containing one or more double bonds, but not having a fully conjugated π-electron system) monocyclic monovalent cyclic hydrocarbon group containing one nitrogen atom and optionally one or more (e.g., from 1 to 5, or from 1 to 4, from 1 to 3, from 1 to 2, or 1) heteroatoms independently selected from sulfur, oxygen, and nitrogen. Representative examples of the nitrogen-containing monocyclic heterocyclyl include, but are not limited to, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl), and diazacyclooctyl. The nitrogen-containing monocyclic heterocyclyl may be unsubstituted or substituted as explicitly defined (e.g., mono-, di-, tri-, or poly-substituted) by a substituent(s) optionally selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl, halogenated C_1-6 alkyl, optionally deuterated C_3-6 cycloalkyl, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH— or any combination thereof.

As used herein, the term “nitrogen-containing bridged heterocyclyl”, used alone or in combination, refers to 3- to 20-membered (e.g., 3- to 15-membered, 3- to 14-membered, 3- to 12-membered, 3- to 11-membered, 3- to 10-membered, 3- to 9-membered, 3- to 8-membered, 3- to 7-membered, 3- to 6-membered, 3- to 5-membered, or 4- to 9-membered) saturated or partially unsaturated (i.e., containing one or more double bonds, but not having a fully conjugated π-electron system) monovalent tricyclic cyclic hydrocarbon group containing one nitrogen atom and optionally one or more (e.g., from 1 to 5, or from 1 to 4, from 1 to 3, from 1 to 2, or 1) heteroatoms independently selected from sulfur, oxygen, and nitrogen. Tricyclic heterocyclyl includes bridged heterocyclyl, e.g., but not limited to, 6-azabicyclo[3.1.1]hept-3-yl, 2,5-diazabicyclo[2.2.1]hept-2-yl, 3,6-diazabicyclo[3.1.1]hept-3-yl, 3-azabicyclo[3.2.1]octan-8-yl, 3,8-diazabicyclo[3.2.1]octan-8-yl, 3,8-diazabicyclo[3.2.1]octan-3-yl and 2,5-diazabicyclo[2.2.2]octan-2-yl. The nitrogen-containing bridged heterocyclyl may be unsubstituted or substituted as explicitly defined (e.g., mono-, di-, tri-, or poly-substituted) by a substituent(s) optionally selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl, halogenated C_1-6 alkyl, optionally deuterated C_3-6cycloalkyl, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH— or any combination thereof.

As used herein, the term “—O-optionally substituted heterocyclyl”, used alone or in combination, refers to a group formed by optionally substituted heterocyclyl connected to oxygen. Optionally, the heterocyclyl of “—O-optionally substituted heterocyclyl” is e.g., 4- to 20-membered monocyclic or bicyclic cyclic heterocyclyl containing one or more (e.g., from 1 to 4, or 1, 2, 3 or 4) heteroatoms independently selected from sulfur, oxygen, and nitrogen, including but not limited to azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl). As used herein, the heterocyclyl is optionally substituted with a substituent selected from deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl, halogenated C_1-6 alkyl, optionally deuterated C_3-6 cycloalkyl, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH— or any combination thereof.

As used herein, the term “heterocyclylene”, used alone or in combination, refers to a 3- to 20-membered saturated or partially unsaturated (i.e., containing one or more double bonds, but not having a fully conjugated π-electron system) monocyclic, bicyclic, or tricyclic bivalent cyclic hydrocarbon group containing one or more (e.g., from 1 to 5, or from 1 to 4, from 1 to 3, from 1 to 2, or 1) heteroatoms independently selected from sulfur, oxygen, and nitrogen. In some embodiments, “heterocyclylene” may refer to e.g., a 3- to 15-membered (optionally 3- to 14-membered, 3- to 12-membered, 3- to 11-membered, 3- to 10-membered, 3- to 9-membered, 3- to 8-membered, 3- to 7-membered, 3- to 6-membered, 3- to 5-membered, or 4- to 9-membered) saturated or partially unsaturated (i.e., containing one or more double bonds, but not having a fully conjugated π-electron system) monocyclic bivalent cyclic hydrocarbon group containing one or more (e.g., from 1 to 5, or from 1 to 4, from 1 to 3, from 1 to 2, or 1) heteroatoms independently selected from sulfur, oxygen, and nitrogen. Representative examples of the monocyclic heterocyclylene include, but are not limited to, azetidinylene, oxetanylene, pyrrolidinylene, imidazolidinylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, and diazacycloheptanylene (e.g., 1,4-diazacycloheptanylene, 4,5-diazacycloheptanylene, 1,3-diazacycloheptanylene). Bicyclic and tricyclic heterocyclylene groups include bridged heterocyclylene, fused heterocyclylene and spiro-heterocyclylene groups such as, but not limited to, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanylene, 3,6-diazabicyclo[3.1.1]heptanylene, 3-azabicyclo[3.2.1]octanylene, 3,8-diazabicyclo[3.2.1]octanylene, 3,8-diazabicyclo[3.2.1]octanylene, 2,5-diazabicyclo[2.2.2]octanylene, and azaspirocycloalkylene (e.g., 3-azaspiro[5.5]undecanylene). The heterocyclylene may be unsubstituted or substituted as explicitly defined (e.g., mono-, di-, tri-, or poly-substituted) by a substituent(s) optionally selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl, halogenated C_1-6 alkyl, optionally deuterated C_3-6 cycloalkyl, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH— or any combination thereof.

As used herein, the term “nitrogen-containing monocyclic heterocyclylene”, used alone or in combination, refers to 3- to 20-membered (e.g., 3- to 15-membered, 3- to 14-membered, 3- to 12-membered, 3- to 11-membered, 3- to 10-membered, 3- to 9-membered, 3- to 8-membered, 3- to 7-membered, 3- to 6-membered, 3- to 5-membered, or 4- to 9-membered) saturated or partially unsaturated (i.e., containing one or more double bonds, but not having a fully conjugated π-electron system) monocyclic bivalent cyclic hydrocarbon group containing one nitrogen atom and optionally one or more (e.g., from 1 to 5, or from 1 to 4, from 1 to 3, from 1 to 2, or 1) heteroatoms independently selected from sulfur, oxygen, and nitrogen. Representative examples of the nitrogen-containing monocyclic heterocyclylene include, but are not limited to, piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidinylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azacycloheptylene, diazacycloheptanylene, azacyclooctylene, and diazacyclooctylene. The nitrogen-containing monocyclic heterocyclylene may be unsubstituted or substituted as explicitly defined (e.g., mono-, di-, tri-, or poly-substituted) by a substituent(s) optionally selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl, halogenated C_1-6 alkyl, optionally deuterated C_3-6 cycloalkyl, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH— or any combination thereof.

As used herein, the term “nitrogen-containing bridged heterocyclylene”, used alone or in combination, refers to 3- to 20-membered (optionally 3- to 15-membered, 3- to 14-membered, 3- to 12-membered, 3- to 11-membered, 3- to 10-membered, 3- to 9-membered, 3- to 8-membered, 3- to 7-membered, 3- to 6-membered, 3- to 5-membered, or 4- to 9-membered) saturated or partially unsaturated (i.e., containing one or more double bonds, but not having a fully conjugated π-electron system) tricyclic bivalent cyclic hydrocarbon group containing one nitrogen atom and optionally one or more (e.g., from 1 to 5, or from 1 to 4, from 1 to 3, from 1 to 2, or 1) heteroatoms independently selected from sulfur, oxygen, and nitrogen. Tricyclic heterocyclylene groups include bridged heterocyclylene, such as but not limited to, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanylene, 3,6-diazabicyclo[3.1.1]heptanylene, 3-azabicyclo[3.2.1]octanylene, 3,8-diazabicyclo[3.2.1]octanylene, 3,8-diazabicyclo[3.2.1]octanylene, and 2,5-diazabicyclo[2.2.2]octanylene. The nitrogen-containing bridged heterocyclylene may be unsubstituted or substituted as explicitly defined (e.g., mono-, di-, tri-, or poly-substituted) by a substituent(s) optionally selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C_1-6 alkyl, halogenated C_1-6 alkyl, optionally deuterated C_3-6 cycloalkyl, optionally deuterated C_1-6 alkoxy, optionally deuterated C_1-6 alkyl-NH—, NH₂—C_1-6 alkylene, optionally deuterated C_1-6 alkyl-NHC(O)—, optionally deuterated C_1-6 alkyl-C(O)NH— or any combination thereof.

As used herein, the term “alkynylene”, used alone or in combination, refers to a linear or branched bivalent hydrocarbon group containing from 2 to 8 (e.g., from 2 to 6, from 2 to 5, from 2 to 4, or preferably 2) carbon atoms and having one or more (e.g., from 1 to 3, from 1 to 2, or 1) carbon-carbon triple bonds. Examples of alkynylene include, but are not limited to, ethynylene, 1-propynylene, 1-butynylene, and 1,3-diynylene.

As used herein, the term “alkynyl”, used alone or in combination, refers to a linear or branched monovalent hydrocarbon group containing from 2 to 8 (e.g., from 2 to 6, from 2 to 5, from 2 to 4, or preferably 2) carbon atoms and having one or more (e.g., from 1 to 3, from 1 to 2, or 1) carbon-carbon triple bonds. Examples of C_2-6 alkynylene include, but are not limited to, ethynyl, 1-propynyl, 1-butynyl, and 1,3-diynyl.

As used herein, the term “alkenylene”, used alone or in combination, refers to a linear or branched divalent hydrocarbon group containing from 2 to 8 (e.g., from 2 to 6, from 2 to 5, from 2 to 4, from 2 to 3, or 2) carbon atoms and having one or more (e.g., from 1 to 3, from 1 to 2, or 1) carbon-carbon double bonds. Examples of alkenylene groups include, but are not limited to, vinylene (e.g., —CH═CH—), 1-propenylene, allylidene, 1-butenylene, 2-butenylene, 3-butenylene, isobutenylene, pentenylene, n-pent-2,4-dienylene, 1-methyl-but-1-enylene, 2-methyl-but-1-enylene, 3-methyl-but-1-enylene, 1-methyl-but-2-enylene, 2-methyl-but-2-enylene, 3-methyl-but-2-enylene, 1-methyl-but-3-enylene, 2-methyl-but-3-enylene, 3-methyl-but-3-enylene, and hexenylene.

As used herein, the term “alkenyl”, used alone or in combination, refers to a linear or branched monovalent hydrocarbon group containing from 2 to 8 (e.g., from 2 to 6, from 2 to 5, from 2 to 4, from 2 to 3, or 2) carbon atoms and having one or more (e.g., from 1 to 3, from 1 to 2, or 1) carbon-carbon double bonds. Examples of C_2-6 alkenyl group include, but are not limited to, vinyl (e.g., CH₂═CH—), 1-propenyl, allyl, 1-butenyl, 2-butenyl, 3-butenyl, isobutenyl, pentenyl, n-pent-2,4-dienyl, 1-methyl-but-1-enyl, 2-methyl-but-1-enyl, 3-methyl-but-1-enyl, 1-methyl-but-2-enyl, 2-methyl-but-2-enyl, 3-methyl-but-2-enyl, 1-methyl-but-3-enyl, 2-methyl-but-3-enyl, 3-methyl-but-3-enyl, and hexenyl.

As used herein, “bornylane” or “bornane” (also known as 1,7,7-trimethylbicyclo[2.2.1]heptane; camphane; bornylane) has a definition known to those skilled in the art. As used herein, “camphanyl” or “bornyl” refers to a monovalent group of bornane, i.e., the group remaining after any one of the hydrogens in bornane is removed. Representative examples of “bornyl” include, but are not limited to, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl, 1,7,7-trimethylbicyclo[2.2.1]heptan-3-yl, 1,7,7-trimethylbicyclo[2.2.1]heptan-4-yl, 1,7,7-trimethylbicyclo[2.2.1]heptan-5-yl, 1,7,7-trimethylbicyclo[2.2.1]heptan-6-yl,

As used herein, “bicyclo[2.2.1]heptane” also known as “norbornane”, has a definition known to those skilled in the art. As used herein, “bicyclo[2.2.1]heptyl” or “norbornyl” refers to a monovalent group of bicyclo[2.2.1]heptane, i.e., the group remaining after any hydrogen in bicyclo[2.2.1]heptane is removed. Representative examples of “bicyclo[2.2.1]heptyl” include, but are not limited to, bicyclo[2.2.1]heptan-2-yl, bicyclo[2.2.1]heptan-3-yl, bicyclo[2.2.1]heptan-4-yl, bicyclo[2.2.1]heptan-5-yl, or bicyclo[2.2.1]heptan-6-yl.

As used herein, the term “bicyclo[2.2.1]heptene” has a definition known to those skilled in the art. As used herein, “bicyclo[2.2.1]heptenyl” refers to a monovalent group of bicyclo[2.2.1]heptene, i.e., the group remaining after any hydrogen in bicyclo[2.2.1]heptene is removed. Representative examples of “bicyclo[2.2.1]heptenyl” include, but are not limited to, bicyclo[2.2.1]hept-5-en-2-yl, bicyclo[2.2.1]hept-5-en-3-yl, or bicyclo[2.2.1]hept-5-en-7-yl.

As used herein, “adamantane” (also known as tricyclo[3.3.1.1^3,7]decane) has a definition known to those skilled in the art, and its structural formula is e.g., as follows:

As used herein, “adamantanyl” refers to a monovalent group of adamantane, that is, the group remaining after any hydrogen in adamantane is removed. Representative examples of “adamantanyl” include, but are not limited to, 1-adamantanyl, 2-adamantanyl, 3-adamantanyl, 4-adamantanyl, 5-adamantanyl, 6-adamantanyl, 7-adamantanyl, 8-adamantanyl, 9-adamantanyl, or 10-adamantanyl.

As used herein, “noradamantane” (also known as octahydro-2,5-methanopentalen) has a definition known to those skilled in the art, and its structural formula is e.g., as follows:

As used herein, “noradamantanyl” refers to a monovalent group of noradamantane, that is, the group remaining after any hydrogen in noradamantane is removed. Representative examples of “noradamantanyl” include, but are not limited to, 1-noradamantanyl, 2-noradamantanyl, 3-noradamantanyl, 4-noradamantanyl, 5-noradamantanyl, 6-noradamantanyl, 7-noradamantanyl, 8-noradamantanyl or 9-noradamantanyl.

As used herein, “adamantanamine” has the definitions known to those skilled in the art, namely referring to an adamantane having an amino substituent, wherein the amino substituent can replace a hydrogen on a carbon at any position in the adamantane. An example of “adamantanamine” can be adamantan-1-amine (corresponding English chemical name is adamantan-1-amine or Tricyclo[3.3.1.1^3,7]decan-1-amine; CAS No.: 768-94-5), with the following structural Formula:

In the present disclosure, the term “leaving group” used alone or in combination is well known to those skilled in the art, which is a leaving molecular fragment (ion or neutral molecule) that carries a pair of electrons from a reactant in chemical reactions, as is a term used in nucleophilic substitution and elimination reactions. Common ionic leaving groups include Cl⁻, Br⁻, I⁻ and sulfonate (such as p-toluenesulfonate, TsO⁻), and neutral molecular leaving groups include water, ammonia and alcohol. In the present disclosure, those skilled in the art can select an appropriate leaving group as needed, such as but not limited to —N₃, halogen, methanesulfonyloxy (MsO⁻), trifluoromethanesulfonyloxy (TfO⁻) or p-toluenesulfonyloxy (TsO⁻), etc.

Salts or pharmaceutically acceptable salts, enantiomers, stereoisomers, solvates, polymorphs of the compounds of Formula (I), Formula (II) or Formula (III) of the present disclosure are also encompassed within the scope of the present invention.

In all embodiments of the present disclosure, the salts or pharmaceutically acceptable salts of the compounds of Formula (I), Formula (II) or Formula (III) refer to non-toxic inorganic or organic acid and/or base addition salts. Examples include: sulfates, hydrohalides (including hydrochlorides and hydrobromates), maleates, sulfonates, citrates, lactates, lactobionates, L-tartrates, fumarates, L-malates, L-lactates, α-ketoglutarates, hippurates, D-glucuronates, D-gluconates, α-D-glucoheptates, glycolates, mucates, L-ascorbates, orotates, picrates, glycinates, alaninates, argininates, cinnamates, laurates, pamoates, sebacates, benzenesulfonates, methanesulfonates, ethanesulfonates, ethanedisulfonates, formates, acetates, 2,2-dichloroacetates, trimethylacetates, propionates, valerates, palmitates, triphenylacetates, 2-ethyl-butanedioates, iodates, nicotiniates, L-pyroglutamates, L-prolinates, ferulates, 2-hydroxyethanesulfonates, nitrates, gentisates, cholates, salicylate, terephthalates, glutarates, adipates, stearates, oleoates, undecylenates, camphorates, camphorsulfonates, dodecyl sulfonates, phosphates, thiocyanates, dihydrophosphates, pyrophosphates, metaphosphates, oxalates, carbonates, malonates, benzoates, mandelates, succinates, pyruvates, p-chlorobenzenesulfonates, 1,5-naphthalenedisulfonates, 3-hydroxy-2-naphthoates, 1-hydroxy-2-naphthoates, naphthalenesulfonates, glycolates, or p-toluenesulfonates, etc.

“Pharmaceutically acceptable carrier” refers to a pharmaceutically acceptable material, such as a filler, stabilizer, dispersant, suspending agent, diluent, excipient, thickener, solvent, or encapsulating material, with which the useful compounds according to the present disclosure are carried or transported into or administered to a patient so that they can perform their intended function. Generally, such constructs are carried or transported from one organ or part of the body to another organ or part of the body. The carrier is compatible with the other ingredients of the formulation, including the compounds useful in the present disclosure, and is not harmful to the patient, and the carrier must be “acceptable”. Some examples of materials that can be used as pharmaceutically acceptable carriers include sugars such as lactose, glucose, and sucrose; starches such as corn starch and potato starch; cellulose and its derivatives such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt; gelatin; talc; excipients such as cocoa butter and suppository wax; oils such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols such as propylene glycol; polyols such as glycerol, sorbitol, mannitol, and polyethylene glycol; esters such as ethyl oleate and ethyl laurate; agar; buffers such as magnesium hydroxide and aluminum hydroxide; surfactant phosphate buffer solution; and other common non-toxic compatible substances used in pharmaceutical formulations.

As used herein, the term “room temperature” refers to the ambient temperature, such as 20-30° C.

As used herein, “stereoisomer” refers to a compound with the same chemical structural formula, but a different arrangement of atoms or groups in space. Stereoisomers include enantiomers, diastereomers, conformational isomers (rotational isomers), geometric isomers (cis/trans isomers), atropisomers, and so on.

As used herein, the term “solvate” refers to an association or complex formed by the interaction between one or more solvent molecules and compounds of the present invention. Examples of solvents include water, isopropanol, ethanol, methanol, DMSO, ethyl acetate, acetic acid and ethanolamine. The term “hydrate” means that a complex formed with water.

As used herein, the term “chiral” refers to a molecule that is nonsuperimposable on its mirror image; whereas “achiral” refers to a molecule that can be superimposed on its mirror image.

As used herein, the term “enantiomers” refers to two isomers of a compound that are non-superimposable mirror images.

As used herein, the term “diastereomers” refers to stereoisomers that have two or more chiral centers but are not mirror images of each other. The diastereomers have different physical properties, such as melting point, boiling point, spectral properties and reactivity. The diastereomeric mixture can be separated by high-resolution analytical operations such as electrophoresis and chromatography, such as HPLC.

As used herein, the term “oxo”, used alone or in combination, refers to ═O.

As used herein, the term “C(O)” or “C(═O)” or “C═O”, used alone or in combination, refers to carbonyl.

As used herein, the term “C(S)” or “C(═S)” or “C═S”, used alone or in combination, refers to thiocarbonyl.

As used herein, “p-menthane” has the definitions known to those skilled in the art, and its structural formula is e.g., as follows:

As used herein, “p-menthanyl” refers to a monovalent group of menthane, that is, the group remaining after any hydrogen in p-menthane is removed. Representative examples of “p-menthanyl” include, but are not limited to,

As used herein, “m-menthane” has the definitions known to those skilled in the art, and its structural formula is e.g., as follows:

As used herein, “m-menthanyl” refers to a monovalent group of m-menthane, that is, the group remaining after any hydrogen in m-menthane is removed. Representative examples of “m-menthanyl” include, but are not limited to,

As used herein, “Quinuclidine” (also known as 1-azabicyclo[2.2.2]octane) has the definitions known to those skilled in the art, and its structural formula is e.g., as follows:

As used herein, “quinuclidinyl” refers to a monovalent group of Quinuclidine, that is, the group remaining after any hydrogen in Quinuclidine is removed. Representative examples of “quinuclidinyl” include, but are not limited to,

EXAMPLES

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present disclosure. The present disclosure may be practiced without some or all of these specific details. In other cases, well-known process operations have not been described in detail in order not to unnecessarily obscure the present disclosure. Although the present disclosure will be described in conjunction with specific embodiments, it should be understood that this is not intended to limit the present disclosure to these embodiments.

The following abbreviations are used throughout the specification and examples:

• • AcOH acetic acid
  • Boc t-Butyloxy carbonyl
  • BINAP 2,2′-Bis(diphenylphosphino)-1,1′-binaphthalene
  • Con. Concentration
  • DCM dichloromethane
  • DIAD Diisopropyl azodicarboxylate
  • DIEA N, N-diisopropylethylamine
  • DMAP 4-Dimethylaminopyridine
  • DMF N,N-dimethylformamide
  • DMSO dimethyl sulfoxide
  • DIPEA or DIEA N, N-diisopropylethylamine
  • EA Ethyl acetate
  • EDCI 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
  • ESI electrospray ionization
  • equiv equivalent
  • EtOH ethanol
  • EtOAc Ethyl acetate HATU 2-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate
  • HPLC high performance liquid chromatography
  • HRMS high resolution mass spectrometry
  • LC-MS liquid chromatography-mass spectrometry
  • LRMS low resolution mass spectrometry
  • LC liquid chromatography
  • Me methyl
  • MeCN acetonitrile
  • MeOH Methanol
  • MeO—Methoxy
  • MS mass spectrometry
  • MsCl Methanesulfonyl chloride
  • MsO-Methanesulfonyloxy
  • ¹H NMR Proton nuclear magnetic resonance
  • HFIP Hexafluoroisopropanol
  • NMP N-methylpyrrolidone
  • rt room temperature
  • tBu tert-butyl
  • TEA triethylamine
  • TFA trifluoroacetic acid
  • TfO-Trifluoromethanesulfonate
  • TLC thin layer chromatography
  • TMS tetramethylsilane
  • TsCl Tosyl chloride
  • TsO-Tosyloxy
  • Xantphos 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene

In the present disclosure, the ¹H NMR spectrum was recorded on a Bruker-500 MHz nuclear magnetic resonance instrument, by using, as a solvent, CD₃OD (δ=3.31 ppm) containing 0.1% TMS (as an internal standard); or using, as a solvent, CDCl₃ (δ=7.26 ppm) containing 0.1% TMS (as an internal standard); or using, as a solvent, DMSO-d₆ (δ=2.50 ppm) containing 0.03% TMS (as an internal standard). LC-MS spectrum was recorded on a Sciex API 2000 mass spectrometer equipped with an Agilent 1100 binary pump and DAD, as well as an ELSD, or on an Agilent 1260-6125B single quadrupole liquid-mass spectrometer equipped with an Agilent 1260 quadrupole pump, DAD, and ELSD; HPLC preparation was measured on a SHIMADZU LC-20AP type instrument, and HPLC purity was measured on a SHIMADZU LC-30AP or Waters 1525 type instrument. Unless otherwise specified, all reactions were performed in the air atmosphere. The reactions were monitored via TLC or LC-MS.

Solvents and reagents are processed as follows:

• • the solvents used in the reactions such as DCM, DMF, anhydrous EtOH, and anhydrous MeOH were all purchased from Sinopharm Group; HPLC preparation uses preparation grade CH₃CN and deionized water; Other reaction substrates, reagents and drugs can be commercially available without special instructions, or can be synthesized using or according to methods known in the art.

General Synthesis Methods

Compounds and/or pharmaceutically acceptable salts thereof of the present disclosure can be synthesized using commercially available raw materials by synthetic techniques known in the art. The synthetic schemes described below illustrate the preparation of most compounds. The starting materials or reagents used in each scheme can be purchased from commercial sources or prepared by methods known to those skilled in the art. One skilled in the art can prepare the salts, racemates, enantiomers, phosphates, sulfates, hydrochlorides and prodrug forms of the compounds of Formula (I) and Formula (II) of the present disclosure according to routine techniques in the art.

In Scheme 1, the group NR₁R₂ corresponds to the group R_d1 or R_a1—X₂— in the compound of Formula (I).

In Scheme 2, the group NR₁R₂ corresponds to the group R_d1 or R_d1—X₂— in the compound of Formula (I).

In Scheme 2, the alkanolamine substrate of the alkylation reaction in step 1 may be varied depending on the target compound, e.g., by changing the carbon number to obtain the desired target compound.

In Scheme 3, the group NR₁R₂ corresponds to the group R_a1 or R_a1—X₂— in the compound of Formula (I).

In Scheme 4, the group NR₁R₂ corresponds to the group R_a1 or R_a1—X₂— in the compound of Formula (I). In Scheme 4, the diol substrate of the alkylation reaction in step 1 may be varied depending on the target compound, e.g., by changing the carbon number to obtain the desired target compound.

In Scheme 5, n=1-10, and the group R corresponds to the group R_a1 in the compound of Formula (I).

In Scheme 6, n=1-10, and the group R corresponds to the group R_a1 in the compound of Formula (I).

In Scheme 8, the group R corresponds to the group R_a1 in the compound of Formula (I).

In Scheme 11, n=0-10.

Depending upon the target compound, the reaction substrate, reaction conditions (including reaction dosage, temperature, time, etc.), and work up, etc. in Scheme 12 can be appropriately modified and adjusted using techniques and methods well known to those skilled in the art to obtain the desired target compound. The group R of the product of Step 3 of Scheme 12 can be modified and adjusted depending on the target compound and the reaction used, e.g., it can be a halogenated substrate for alkylation reactions, e.g.,

or a carboxylic acid substrate for condensation reaction

wherein n=0-10.

For example, An exemplary procedure for Scheme 12 is shown below:

Step 1: to a solution of 3-(5-bromo-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (1.0 eq.) and potassium Boc-protected piperazine trifluoroborate (1.3 eq.) in dioxane were added palladium catalyst (0.2 eq.) and potassium carbonate (2.0 eq.). The reaction solution was heated to 80° C. and stirred under nitrogen protection for 18 hours. After monitoring the reaction via TLC and confirming its completion, the reaction solution was cooled to room temperature, and concentrated under vacuum. The residue was washed with water, extracted with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was subjected to silica gel column chromatography for purification to give tert-butyl 4-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)methyl)piperazine-1-carboxylate as a pale yellow solid.

Step 2: to a solution of the product from Step 1 in dichloromethane was added trifluoroacetic acid. The reaction solution was stirred at room temperature for 2 hours. After monitoring the reaction via LCMS and confirming its completion, the reaction solution was concentrated under vacuum to give 3-(2-methyl-4-oxo-5-(piperazin-1-ylmethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione.

Step 3 (alkylation): to a solution of 3-(2-methyl-4-oxo-5-(piperazin-1-ylmethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione (1.0 eq.) and halogenated substrate (1.3 eq.) in anhydrous DMF were added triethylamine (3.0 eq.) and sodium iodide (1.0 eq.). The reaction solution was stirred at 50° C. for 2 hours. After monitoring the reaction via LCMS and confirming its completion, the reaction solution was filtered. The filtrate was subjected to HPLC for purification to give the target compound.

Alternatively, Step 3 (condensation reaction): to a solution of 3-(2-methyl-4-oxo-5-(piperazin-1-ylmethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione (1.0 eq.) and carboxylic acid substrate (1.3 eq.) in anhydrous DMF were added triethylamine (3.0 eq.) and HATU (1.2 eq.). The reaction solution was stirred at 50° C. for 2 hours. After monitoring the reaction via LCMS and confirming its completion, the reaction solution was filtered. The filtrate was subjected to HPLC for purification to give the target compound.

Depending upon the target compounds, the above schemes and their reaction substrates, reaction conditions (including reaction dosage, temperature, duration, etc.), work up, etc. can be appropriately modified and adjusted by techniques and methods well known to those skilled in the art to obtain the desired target compounds. The obtained target compounds can be further modified by the substituents and the like to obtain subsequent target compounds through methods well known to those skilled in the art.

EXAMPLES

Intermediate Example 1: Preparation of 3-(5-bromo-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02600)

The target compound 3-(5-bromo-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02600) was prepared by referring to the method of step 1 of Scheme 5.

At room temperature, in a 500 mL single-neck flask, 2-amino-6-bromobenzoic acid (10 g, 46.29 mmol), imidazole (3.78 g, 55.55 mmol), acetonitrile (150 mL), and acetyl chloride (3.96 mL, 55.55 mmol) were sequentially added. Subsequently, the three-necked flask was vacuumed and backfilled with nitrogen. The reaction mixture was stirred overnight at room temperature, and then 3-aminopiperidine-2,6-dione hydrochloride (8.38 g, 50.92 mmol), another batch of imidazole (3.78 g, 55.548 mmol), and triphenyl phosphite (14.557 mL, 55.548 mmol) were added to the reaction mixture. The resulting reaction mixture was stirred at 80° C. for 18 hours. After the reaction was completed as detected by LCMS, the mixture was added to 500 mL of water, resulting in the precipitation of a solid. The precipitated solid was washed with water and ethyl acetate, dried to give GT-02600 (off-white solid, 12 g, yield 74.0%). ¹H NMR (400 MHz, DMSO) δ 11.04 (s, 1H), 7.73 (dt, J=13.5, 6.7 Hz, 1H), 7.69-7.53 (m, 2H), 5.24 (dd, J=11.4, 5.7 Hz, 1H), 2.90-2.77 (m, 1H), 2.69-2.60 (m, 4H), 2.60-2.53 (m, 1H), 2.20-2.11 (m, 1H). LCMS (ESI) m/z: calcd for C₁₄H₁₃BrN₃O₃⁺[M+H]⁺, 350.01/352.01; found, 350.0/352.0.

Intermediate Example 2: Preparation of 3-(5-(5-hydroxypent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02597)

The target compound 3-(5-(5-hydroxypent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02597) was prepared by referring to the method of step 2 of Scheme 5.

A 100 mL reaction flask was charged sequentially with the compound GT-02600 (1 eq.), Pd(PPh₃)Cl₂ (0.1 eq.) and cuprous iodide (1 eq.), and then under nitrogen protection, DMF (25 mL), TEA (3 mL), and pent-4-yn-1-ol (3 eq.). After the addition was complete, the mixture was heated to 90° C. and stirred for 18 hours. After monitoring the reaction via TLC and confirming its completion, the reaction mixture was concentrated, and subjected to column chromatography (dichloromethane:methanol=20:1) for purification to give the target compound GT-02597 (grayish white solid, 1.7 g, yield 93.59%). ¹H NMR (400 MHz, DMSO) δ 11.02 (s, 1H), 8.94 (s, 1H), 7.71 (dd, J=8.1, 7.6 Hz, 1H), 7.51 (ddd, J=16.4, 7.8, 1.1 Hz, 2H), 5.22 (dd, J=11.6, 5.7 Hz, 1H), 3.54 (dd, J=11.5, 6.1 Hz, 2H), 2.84 (ddd, J=16.0, 13.2, 4.3 Hz, 1H), 2.72-2.57 (m, 5H), 2.55-2.52 (m, 2H), 2.15 (dd, J=10.9, 5.0 Hz, 1H), 1.75-1.61 (m, 2H). LCMS (ESI) m/z: calcd for C₁₉H₂₀N₃O₄⁺[M+H]⁺, 354.14; found, 354.2.

Intermediate Example 3: Preparation of 3-(5-(8-hydroxyoct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02637)

Following the method of Scheme 5 and the method of Intermediate Example 2, under appropriate conditions understood in the field, the target product GT-02637 was prepared (pale yellow solid, 1.1 g, yield 49.85%). LCMS (ESI) m/z: calcd for C₂₂H₂₆N₃O₄⁺ [M+H]⁺, 396.19; found, 396.2.

Intermediate Example 4: Preparation of 5-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroqninazolin-5-yl)pent-4-yn-1-yl methanesulfonate (729092)

The target compound 5-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)pent-4-yn-1-yl methanesulfonate (729092) was prepared by referring to the method of step 3 of Scheme 5.

A 100 mL reaction flask was charged sequentially with 3-(5-(5-hydroxypent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02597) (1 eq.) and DCM (50 mL), and then under nitrogen protection at room temperature, TEA (3 eq.) and MsCl (2 eq.). After the addition was complete, the mixture was stirred at room temperature for 1 hour. After monitoring the reaction via TLC and confirming its completion, the reaction mixture was washed with water twice and brine once, concentrated, and then slurried (petroleum ether:ethyl acetate=1:1) to give the target compound (729092) (pale yellow solid, 170 mg, yield 84.23%). LCMS (ESI) m/z: calcd for C₂₀H₂₂N₃O₆S⁺ [M+H]⁺, 432.12; found, 432.1.

Intermediate Example 5: Preparation of 8-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)oct-7-yn-1-yl methanesulfonate (729101)

Following the method of Scheme 5 and the method of Intermediate Example 4, under appropriate conditions understood in the field, the target product 729101 was prepared (pale yellow solid, 120 mg, yield 50.11%). LCMS (ESI) m/z: calcd for C₂₃H₂₈N₃O₆S⁺ [M+H]⁺, 474.17; found, 474.2.

Intermediate Example 6: Preparation of 3-(5-(5-hydroxypentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02640)

The target compound 3-(5-(5-hydroxypentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02640) was prepared by referring to the method of step 1 of Scheme 6.

A 250 mL reaction flask was charged sequentially with 3-(5-(5-hydroxypent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02597) (1 eq.) and ethanol (80 mL), and then under nitrogen protection, 10% wet Pd/C (10 eq.). The mixture was purged with a hydrogen balloon three times, and heated to 50° C. and stirred for 18 h. After the reaction was completed as detected by LCMS, the reaction mixture was filtered and concentrated to give the target compound 3-(5-(5-hydroxypentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02640) (off-white solid, 200 mg, yield 88.99%). LCMS (ESI) m/z: calcd for C₁₉H₂₄N₃O₄⁺ [M+H]⁺, 358.18; found, 358.2.

Intermediate Example 7: Preparation of 3-(5-(8-hydroxyoctyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02760)

Following the method of Scheme 6 and the method of Intermediate Example 6, under appropriate conditions understood in the field, the target product GT-02760 was prepared (grayish white solid, 250 mg, yield 74.24%). LCMS (ESI) m/z: calcd for C₂₂H₃₀N₃O₄⁺ [M+H]⁺, 400.22; found, 400.2.

Intermediate Example 8: Preparation of 5-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)pentyl methanesulfonate (729109)

The target compound 5-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)pentyl methanesulfonate (729109) was prepared by referring to the method of step 2 of Scheme 6.

A 100 mL reaction flask was charged sequentially with 3-(5-(5-hydroxypentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02640) (1 eq.) and DCM (50 mL), and then under nitrogen protection at room temperature, TEA (3 eq.) and MsCl (2 eq.). After the addition was complete, the mixture was stirred at room temperature for 1 hour. After monitoring the reaction via TLC and confirming its completion, the reaction mixture was washed with water twice and brine once, concentrated, and then slurried (petroleum ether:ethyl acetate=1:1) to give the target compound (729109) (pale yellow solid, 150 mg, yield 64.79%). LCMS (ESI) m/z: calcd for C₂₀H₂₆N₃O₆S⁺ [M+H]⁺, 436.15; found, 436.2.

Intermediate Example 9: Preparation of 8-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)octyl methanesulfonate (729119)

Following the method of Scheme 6 and the method of Intermediate Example 8, under appropriate conditions understood in the field, the target product 729119 was prepared (pale yellow solid, 100 mg, yield 38.02%). LCMS (ESI) m/z: calcd for C₂₃H₃₂N₃O₆S⁺ [M+H]⁺, 478.20; found, 478.2.

Intermediate Example 10: Preparation of (1s,3s)-N-(prop-2-yn-1-yl)adamantan-1-amine (GT-M-24)

The target compound GT-M-24 was prepared by referring to the method of step 1 of Scheme 7.

Adamantanamine (1 eq.) was added to a 250 mL reaction flask, followed by the addition of 100 mL of DMF, potassium carbonate (2 eq.), and 3-bromoprop-1-yne (1 eq.). The mixture was then stirred at room temperature under nitrogen protection for 18 hours. After the reaction was completed as detected by TLC, the reaction mixture was added to water and extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, concentrated, and subjected to column chromatography (ethyl acetate: petroleum ether=1:1) for purification to give the target compound GT-M-24 (colorless oil, 2.3 g, yield 36.77%). ¹H NMR (400 MHz, DMSO) δ 3.27 (s, 2H), 2.93 (s, 1H), 1.99 (s, 3H), 1.62-1.47 (m, 12H). LCMS (ESI) calcd., 190.1; found, 190.2.

Intermediate Example 11: Preparation of tert-butyl (2-(2-(((1s,3s)-adamantan-1-yl)amino)ethoxy)ethyl)carbamate (729022)

The target compound 729022 was prepared by referring to the method of step 1 of Scheme 8.

Tert-butyl (2-(2-bromoethoxy)ethyl)carbamate (1 eq.) was added into a 50 mL reaction flask, followed by the addition of 10 mL of DMF, adamantanamine (1.3 eq.), potassium carbonate (3 eq.), and sodium iodide (1 eq.). The mixture was then stirred at 80° C. under nitrogen protection for 3 hours.

After the reaction was completed as detected by TLC, the reaction mixture was added to water and extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, concentrated, and subjected to column chromatography (dichloromethane:ethanol=20:1) for purification to give the target compound tert-butyl (2-(2-(((1s,3s)-adamantan-1-yl)amino)ethoxy)ethyl)carbamate (729022) (colorless oil, 250 mg, yield 65.79%).

Intermediate Example 12: Preparation of tert-butyl (2-(2-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethoxy)ethyl)carbamate (729031)

Following the method of Scheme 8 and the method of Intermediate Example 11, under appropriate conditions understood in the field, the target product 729031 was prepared (colorless oil, 310 mg, yield 86.11%).

Intermediate Example 13: Preparation of tert-butyl (2-(2-(4-methyl-1,4-diazepan-1-yl)ethoxy)ethyl)carbamate (729032)

Following the method of Scheme 8 and the method of Intermediate Example 11, under appropriate conditions understood in the field, the target product 729032 was prepared (colorless oil, 270 mg, yield 79.41%).

Intermediate Example 14: Preparation of tert-butyl (2-(2-(2-(((1s,3s)-adamantan-1-yl)amino)ethoxy)ethoxy)ethyl)carbamate (730030)

Following the method of Scheme 8 and the method of Intermediate Example 11, under appropriate conditions understood in the field, the target product 730030 was prepared (colorless oil, 80 mg, yield 61.54%). ¹H NMR (500 MHz, CDCl₃) δ 3.69-3.60 (m, 6H), 3.55 (t, J=5.2 Hz, 2H), 3.35-3.29 (m, 2H), 2.90-2.79 (m, 2H), 2.12-2.07 (m, 3H), 1.73-1.68 (m, 6H), 1.66-1.60 (m, 6H), 1.44 (s, 9H).

Intermediate Example 15: Preparation of tert-butyl (5-(((1s,3s)-adamantan-1-yl)amino) pentyl)carbamate (730037)

Following the method of Scheme 8 and the method of Intermediate Example 11, under appropriate conditions understood in the field, the target product 730037 was prepared (colorless oil, 600 mg, yield 54.04%).

Intermediate Example 16: Preparation of tert-butyl (5-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)pentyl)carbamate (730055)

Following the method of Scheme 8 and the method of Intermediate Example 11, under appropriate conditions understood in the field, the target product 730055 was prepared (yellow oil, 100 mg, yield 21.28%).

Intermediate Example 17: Preparation of tert-butyl (2-(2-(2-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethoxy)ethoxy)ethyl)carbamate (730056)

Following the method of Scheme 8 and the method of Intermediate Example 11, under appropriate conditions understood in the field, the target product 730056 was prepared (yellow oil, 50 mg, yield 16.67%).

Intermediate Example 18: Preparation of tert-butyl (2-(2-(2-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethoxy)ethoxy)ethyl)carbamate (730057)

Following the method of Scheme 8 and the method of Intermediate Example 11, under appropriate conditions understood in the field, the target product 730057 was prepared (yellow oil, 262 mg, yield 49.95%).

Intermediate Example 19: Preparation of (1s,3s)-N-(2-(2-aminoethoxy)ethyl)adamantan-1-amine (729023)

The target compound 729023 was prepared by referring to the method of step 2 of Scheme 8.

Tert-butyl (2-(2-(((1s,3s)-adamantan-1-yl)amino)ethoxy)ethyl)carbamate (729022) (1 eq.) was added into a 20 mL reaction flask, followed by the addition of 3 mL of DCM and 1 mL of TFA. The mixture was then stirred at room temperature for 1 hour. After the reaction was completed as detected by TLC, the reaction mixture was concentrated and lyophilized to give the target compound (729023) (colorless oil, 420 mg, yield 97.91%).

Intermediate Example 20: Preparation of (3as,6as)-N-(2-(2-aminoethoxy)ethyl)hexahydro-2,5-methanopentalen-3a(1H)-amine (729033)

Following the method of step 2 of Scheme 8 and the method of Intermediate Example 19, under appropriate conditions understood in the field, the target product 729033 was prepared (colorless oil, 540 mg, yield 99.83%).

Intermediate Example 21: Preparation of 2-(2-(4-methyl-1,4-diazepan-1-yl)ethoxy)ethan-1-amine (729035)

Following the method of step 2 of Scheme 8 and the method of Intermediate Example 19, under appropriate conditions understood in the field, the target product 729035 was prepared (colorless oil, 580 mg, yield 98.47%).

Intermediate Example 22: Preparation of (1s,3s)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)adamantan-1-amine (730039)

Following the method of step 2 of Scheme 8 and the method of Intermediate Example 19, under appropriate conditions understood in the field, the target product 730039 was prepared (colorless oil, 100 mg, yield 76.62%).

Intermediate Example 23: Preparation of N¹-((1s,3s)-adamantan-1-yl)pentane-1,5-diamine (730041)

Following the method of step 2 of Scheme 8 and the method of Intermediate Example 19, under appropriate conditions understood in the field, the target product 730041 was prepared (yellow oil, 130 mg).

Intermediate Example 24: Preparation of N¹-((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)pentane-1,5-diamine 730064)

Following the method of step 2 of Scheme 8 and the method of Intermediate Example 19, under appropriate conditions understood in the field, the target product 730064 was prepared (yellow oil, 60 mg, yield 42.96%).

Intermediate Example 25: Preparation of (3as,6as)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)hexahydro-2,5-methanopentalen-3a(1H)-amine (730060)

Following the method of step 2 of Scheme 8 and the method of Intermediate Example 19, under appropriate conditions understood in the field, the target product 730060 was prepared (yellow oil, 50 mg, yield 74.23%).

Intermediate Example 26: Preparation of 5-(4-methyl-1,4-diazepan-1-yl)pentan-1-amine (730065)

Following the method of step 2 of Scheme 8 and the method of Intermediate Example 19, under appropriate conditions understood in the field, the target product 730065 was prepared (yellow oil, 200 mg, yield 53.49%).

Example 1: Preparation of 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03306)

The target compound GT-03306 was prepared by referring to the method of Scheme 9.

Preparation of 2-((3r,5r,7r)-adamantan-1-yl)ethyl 4-methylbenzenesulfonate

To a solution of 2-((3r,5r,7r)-adamantan-1-yl)ethan-1-ol (1 g, 5.55 mmol) in dichloromethane (30 mL) were added diisopropylethylamine (1.5 mL, 11.09 mmol) and p-toluenesulfonyl chloride (1.3 g, 6.66 mmol). The reaction mixture was stirred at room temperature for 18 hours. After monitoring the reaction via TLC and confirming its completion, the reaction solution was washed with water (60 mL) and extracted with dichloromethane (50 mL×3). The organic phases were combined and washed with saturated brine (50 mL×2), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, and the residue was subjected to column chromatography (eluent (v/v): PE/EtOAc=20/1) for purification to give 2-((3r,5r,7r)-adamantan-1-yl)ethyl 4-methylbenzenesulfonate as a colorless oily liquid (890 mg, yield: 48%).

Preparation of tert-butyl 4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazine-1-carboxylate

To a solution of 2-((3r,5r,7r)-adamantan-1-yl)ethyl 4-methylbenzenesulfonate (500 mg, 1.5 mmol) in acetonitrile (10 mL) were added potassium carbonate (620 mg, 4.5 mmol) and tert-butyl piperazine-1-carboxylate (556 mg, 3.0 mmol). The reaction mixture was stirred at 60° C. for 18 hours.

After monitoring the reaction via TLC and confirming its completion, the reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The residue was washed with water (30 mL) and extracted with dichloromethane (50 mL×3). The organic phases were combined, washed with saturated brine (50 mL×1), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, and the residue was subjected to column chromatography (eluent: dichloromethane/methanol=20/1) for purification to give tert-butyl 4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazine-1-carboxylate as a colorless oily liquid (180 mg, yield: 35%). LC/MS (ESI, m/z) 349.4 [M+H]⁺.

Preparation of 1-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazine 2,2,2-trifluoroacetaldehyde

To a solution of tert-butyl 4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazine-1-carboxylate (180 mg, 0.52 mmol) in dichloromethane (10 mL) was added trifluoroacetic acid (0.38 mL, 5.17 mmol).

The reaction solution was stirred at room temperature for 2 hours. After monitoring the reaction via TLC and confirming its completion, the reaction solution was concentrated under reduced pressure to give 1-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazine 2,2,2-trifluoroacetaldehyde as a pale yellow solid (200 mg, yield: 107%). LC/MS (ESI, m/z) 249.3 [M+H]+.

Preparation of 3-(5-((3-bromopropyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione

To a solution of 3-(5-mercapto-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (200 mg, 0.66 mmol) in N,N-dimethylformamide (20 mL) were added diisopropylethylamine (0.33 mL, 1.98 mmol) and 1,3-dibromopropane (173 mg, 0.86 mmol). The reaction solution was stirred at room temperature for 18 hours. After monitoring the reaction via TLC and confirming its completion, the reaction solution was washed with water (50 mL) and extracted with ethyl acetate (50 mL×3). The organic phases were combined, washed with saturated brine (50 mL×1), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, and the residue was slurried with ethyl acetate/petroleum ether (1/2, 20 mL). After filtration, the solid was collected to give 3-(5-((3-bromopropyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione as white solid (161 mg, yield: 58%). LC/MS (ESI, m/z) 424.1, 426.1 [M+H]⁺.

Preparation of 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03306)

To a solution of 1-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazine trifluoroacetate (20 mg, 0.05 mmol) in N,N-dimethylformamide (2 mL) were added diisopropylethylamine (0.03 mL, 0.19 mmol) and 3-(5-((3-bromopropyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (13 mg, 0.05 mmol). The reaction solution was stirred at 80° C. for 18 hours. After the reaction was completed as detected by LC/MS, the reaction solution was filtered, and the filtrate was subjected to HPLC for purification to give the white solid compound GT-03306 (6 mg, yield: 16%). ¹H NMR (400 MHz, MeOD) δ 7.70 (t, J=8.0 Hz, 1H), 7.35 (d, J=8.0 Hz, 2H), 5.24-5.28 (m, 1H), 3.74 (t, J=6.0 Hz, 1H), 3.21-3.29 (m, 2H), 3.14-3.18 (m, 2H), 3.01-3.08 (m, 4H), 2.92-2.97 (m, 3H), 2.78 2.87 (m, 2H), 2.70-2.73 (m, 2H), 2.22-2.26 (m, 1H), 2.04-2.08 (m, 2H), 2.00 (brs, 4H), 1.78-1.81 (m, 4H), 1.70-1.74 (m, 4H), 1.60 (brs, 8H). LC/MS (ESI) m/z: calcd for C₃₃H₄₆N₅O₃S⁺ [M+H]⁺, 592.3; found, 592.3.

Example 2: Preparation of 3-(5-((3-(4-benzhydrylpiperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03384)

Following the method of Scheme 9 and the method of Example 1, under appropriate conditions understood in the field, the target compound GT-03384 was prepared (pale yellow solid, 20 mg, yield: 47.48%). ¹H NMR (400 MHz, MeOD) δ 7.78 (s, 1H), 7.62 (brs, 4H), 7.49 (s, 1H), 7.30-7.34 (m, 5H), 7.24-7.27 (m, 2H), 5.32 (br, 1H), 5.02-5.19 (m, 1H), 3.58-3.62 (m, 4H), 3.33-3.37 (m, 4H), 3.05-3.09 (m, 4H), 2.67-2.89 (m, 6H), 2.16-2.27 (m, 3H). LC/MS (ESI) m/z: calcd for C₃₄H₃₈N₅O₃S⁺[M+H]⁺, 596.3; found, 596.3.

Example 3: Preparation of 3-(5-((3-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03387)

Following the method of Scheme 9 and the method of Example 1, under appropriate conditions understood in the field, the target compound GT-03387 was prepared (pale yellow solid, 24 mg, yield: 53.52%). ¹H NMR (400 MHz, MeOD) δ 7.76 (t, J=8.0 Hz, 1H), 7.68 (dd, J=8.0, 4.0 Hz, 1H), 7.45 (t, J=8.0 Hz, 3H), 7.32 (d, J=8.0 Hz, 1H), 7.16 (t, J=8.0 Hz, 1H), 6.98 (t, J=8.0 Hz, 4H), 5.28 (dd, J=11.3, 5.6 Hz, 1H), 4.54 (s, 1H), 3.45 (s, 2H), 3.34-3.24 (m, 4H), 3.13-2.90 (m, 5H), 2.88-2.75 (m, 4H), 2.73-2.63 (m, 2H), 2.42 (s, 1H), 2.27-2.17 (m, 1H), 2.16-2.05 (m, 2H). LC/MS (ESI) m/z: cal. C₃₄H₃₆F₂N₅O₃S⁺ [M+H]⁺, 632.2; found, 632.2.

Example 4: Preparation of 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03301)

The target compound GT-03301 was prepared by referring to the method of Scheme 10.

Preparation of 3-(5-((3-((tert-butyldimethylsilyl)oxy)propyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (a2) and 3-(5-((3-hydroxypropyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (a3):

To a solution of 3-(5-fluoro-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (1 g, 3.46 mmol) in N-methylpyrrolidone (20 mL) were added triethylamine (1.92 mL, 13.83 mmol) and 2-((tert-butyldimethylsilyl)oxy)-1-amino-ethane (1.21 g, 6.91 mmol). The reaction solution was stirred at 90° C. for 18 hours. After the reaction was completed as detected by TLC, the reaction mixture was cooled to room temperature, washed with water (100 mL), and extracted with ethyl acetate (100 mL×3). The organic phases were combined, washed with saturated brine (50 mL×2), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, and the residue was subjected to column chromatography (eluent: dichloromethane/methanol=20/1) for purification to give pale yellow solid 3-(5-((3-((tert-butyldimethylsilyl)oxy)propyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (890 mg, yield: 58%)(LC/MS (ESI, m/z) 445.3 [M+H]⁺) and pale yellow solid 3-(5-((3-hydroxypropyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (210 mg, yield: 19%) (LC/MS (ESI, m/z) 331.2 [M+H]+).

Preparation of 3-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)propyl methanesulfonate

To a solution of 3-(5-((3-hydroxypropyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (210 mg, 0.64 mmol) in dichloromethane (20 mL) were added triethylamine (0.27 mL, 1.91 mmol) and methanesulfonyl chloride (0.098 mL, 1.27 mmol). The reaction solution was stirred at room temperature for 1 hour. After monitoring the reaction via TLC and confirming its completion, the reaction solution was washed with water (50 mL) and extracted with dichloromethane (50 mL×3). The organic phases were combined, washed with saturated brine (30 mL), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, and the residue was subjected to column chromatography (eluent: dichloromethane/methanol=20/1) for purification to give pale yellow solid 3-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)propyl methanesulfonate (180 mg, yield: 69%). LC/MS (ESI, m/z) 409.2 [M+H]⁺.

Preparation of the Target Compound GT-03301:

To a solution of 3-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)propyl methanesulfonate (20 mg, 0.049 mmol) in N,N-dimethylformamide (2 mL) were added diisopropylethylamine (0.03 mL, 0.19 mmol) and 1-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazine 2,2,2-trifluoroacetaldehyde (13 mg, 0.054 mmol). The reaction solution was stirred at 80° C. for 18 hours. After monitoring the reaction via LC/MS and confirming its completion, the reaction solution was filtered, and the filtrate was subjected to HPLC for purification to give the white solid compound GT-03301 (8 mg, yield: 25%). ¹H NMR (400 MHz, MeOD) δ 7.75 (t, J=8.0 Hz, 1H), 6.93 (d, J=8.0 Hz, 1H), 6.82 (d, J=8.0 Hz, 1H), 5.37-5.41 (m, 1H), 4.47-4.56 (m, 1H), 3.49-3.53 (m, 3H), 3.21-3.29 (m, 5H), 3.08-3.16 (m, 4H), 3.01-3.07 (m, 1H), 2.92-2.97 (m, 3H), 2.22-2.26 (m, 1H), 2.03 (brs, 4H), 1.78-1.81 (m, 4H), 1.70-1.74 (m, 4H), 1.60 (brs, 8H). LC/MS (ESI) m/z: calcd for C₃₂H₄₅N₆O₃⁺ [M+H]⁺, 561.4; found, 561.4.

Example 5: Preparation of 3-(8-((2-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)ethyl)amino)-3-methyl-1-oxoisoquinolin-2(1H)-yl)piperidine-2,6-dione (GT-03388)

Following the method of Scheme 10 and the method of Example 4, under appropriate conditions understood in the field, the target compound GT-03388 was prepared (pale yellow solid, 15 mg, yield: 33.80%). ¹H NMR (400 MHz, DMSO) δ 11.07 (s, 1H), 8.04 (s, 1H), 7.97 (brs, 3H), 7.60 (t, J=8.0 Hz, 1H), 7.31 (t, J=8.0 Hz, 3H), 7.25-7.16 (m, 3H), 6.84 (t, J=8.0 Hz, 1H), 5.66-5.72 (m, 1H), 5.26-5.31 (m, 1H), 3.79-3.83 (m, 2H), 3.71-3.74 (m, 2H), 3.51-3.58 (m, 2H), 3.39-3.44 (m, 2H), 3.18-3.29 (m, 3H), 2.82-3.02 (m, 3H), 2.71 (s, 3H), 2.58-2.61 (m, 2H), 2.18-2.21 (m, 1H). LC/MS (ESI) m/z: calcd for C₃₄H₃₆F₂N₅O₃⁺ [M+H]+, 600.3; found, 600.3.

Example 6: Preparation of 3-(5-((4-(((3s,5s,7s)-adamantan-1-yl)amino)butyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-01818)

The target compound was prepared by referring to the method of step 3 of Scheme 1.

To a solution of the compound 3-(5-fluoro-2-methyl-4-oxo-3,4-dihydroquinazolin-3-yl)piperidine-2,6-dione (80 mg, 0.28 mmol) in anhydrous NMP were added sequentially DIEA (0.14 mL, 0.83 mmol) and N1-(adamantan-1-yl)butane-1,4-diamine (61.5 mg, 0.28 mmol). The reaction solution was stirred at 130° C. for 8 hours. After monitoring the reaction via TLC and confirming its completion, the reaction solution was cooled to room temperature and filtered. The filtrate was subjected to HPLC for purification to give the target compound (pale yellow solid, 18 mg, yield: 12%). ¹H NMR (500 MHz, MeOD) δ 7.63 (t, J=5.0 Hz, 1H), 6.81 (d, J=5.0 Hz, 1H), 6.68 (d, J=5.0 Hz, 1H), 5.30 (dd, J=5.0, 10.0 Hz, 1H), 3.29-3.32 (m, 2H), 2.92-2.95 (m, 2H), 2.84 (s, 3H), 2.65-2.73 (m, 3H), 2.22-2.26 (m, 1H), 2.11 (s, 3H), 1.82-1.85 (m, 6H), 1.68-1.673 (m, 7H), 1.62-1.64 (m, 3H). LC/MS (ESI) calcd for C₂₈H₃₈N₅O₃⁺ [M+H]⁺, 492.30; found, 492.4.

Example 7: Preparation of 3-(5-((6-(((3s,5s,7s)-adamantan-1-yl)amino)hexyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02235)

Following the method of Scheme 1 and the method of Example 6, under appropriate conditions understood in the field, the target compound GT-02235 was prepared (pale yellow solid, 15 mg, yield 45%). ¹H NMR (400 MHz, DMSO) δ 11.01 (s, 1H), 8.34 (brs, 2H), 7.51 (t, J=8.0 Hz, 1H), 6.66 (d, J=8.0 Hz, 1H), 6.53 (d, J=8.0 Hz, 1H), 5.23-5.20 (m, 1H), 2.89-2.81 (m, 2H), 2.61-2.58 (m, 2H), 2.12 (s, 3H), 1.85-1.81 (m, 7H), 1.69-1.57 (m, 14H), 1.42-1.38 (m, 6H). LC/MS (ESI) calcd for C₃₀H₄₂N₅O₃⁺ [M+H]⁺, 520.33; found, 520.3.

Example 8: Preparation of 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02237)

Following the method of Scheme 1 and the method of Example 6, under appropriate conditions understood in the field, the target compound GT-02237 was prepared (pale yellow solid, 14 mg, yield 54%). ¹H NMR (400 MHz, DMSO) δ 11.12 (s, 1H), 8.71 (brs, 2H), 7.61 (t, J=8.0 Hz, 1H), 6.84 (d, J=8.0 Hz, 1H), 6.68 (d, J=8.0 Hz, 1H), 5.33-5.29 (m, 1H), 3.22 (t, J=8.0 Hz, 2H), 2.88-2.75 (m, 6H), 2.68-2.56 (m, 2H), 2.28-2.17 (m, 1H), 2.11 (s, 3H), 1.87 (s, 6H), 1.68-1.57 (m, 10H), 1.34 (s, 6H). LC/MS (ESI) calcd for C₃₁H₄₄N₅O₃⁺ [M+H]⁺, 534.34; found, 534.4.

Example 9: Preparation of 3-(5-((2-(((1r,3r,5r,7r)-adamantan-2-yl)amino)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02325)

Following the method of Scheme 1 and the method of Example 6, under appropriate conditions understood in the field, the target compound GT-02325 was prepared (pale yellow solid, 12 mg, yield 56%). ¹H NMR (400 MHz, DMSO) δ 11.03 (s, 1H), 8.66 (brs, 2H), 7.57 (t, J=8.0 Hz, 1H), 6.76 (d, J=8.0 Hz, 1H), 6.73 (d, J=8.0 Hz, 1H), 5.26-5.22 (m, 1H), 3.89-3.80 (m, 1H), 3.69-3.65 (m, 2H), 3.19-3.15 (m, 2H), 2.86-2.83 (m, 1H), 2.62 (s, 3H), 2.16-2.12 (m, 3H), 2.05-2.02 (m, 3H), 1.86-1.82 (m, 6H), 1.72-1.68 (m, 6H). LC/MS (ESI) calcd for C₂₆H₃₄N₅O₃⁺ [M+H]⁺, 464.59; found, 464.7.

Example 10: Preparation of 3-(5-((3-(((1r,3r,5r,7r)-adamantan-2-yl)amino)propyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02326)

Following the method of Scheme 1 and the method of Example 6, under appropriate conditions understood in the field, the target compound GT-02326 was prepared (pale yellow solid, 15 mg, yield 46%). ¹H NMR (400 MHz, DMSO) δ 11.01 (s, 1H), 8.42 (brs, 2H), 7.54 (t, J=8.0 Hz, 1H), 6.71 (d, J=8.0 Hz, 1H), 6.61 (d, J=8.0 Hz, 1H), 5.25-5.21 (m, 1H), 3.57-3.55 (m, 1H), 3.54-3.51 (m, 2H), 3.06-3.00 (m, 2H), 2.86-2.83 (m, 1H), 2.60 (s, 3H), 2.36-2.32 (m, 2H), 2.17-2.11 (m, 3H), 2.03-1.99 (m, 2H), 1.89-1.83 (m, 6H), 1.77-1.71 (m, 6H). LC/MS (ESI) calcd for C₂₇H₃₆N₅O₃⁺ [M+H]⁺, 478.62; found, 478.6.

Example 11: Preparation of 3-(5-((6-(((2R,3as,5S,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)hexyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02494)

Following the method of Scheme 1 and the method of Example 6, under appropriate conditions understood in the field, the target compound GT-02494 was prepared (pale yellow solid, 50 mg, yield 51%). ¹H NMR (400 MHz, DMSO) δ 11.07 (s, 1H), 9.15 (brs, 2H), 7.57 (t, J=8.0 Hz, 1H), 6.75 (d, J=8.0 Hz, 1H), 6.62 (d, J=8.0 Hz, 1H), 5.29-5.24 (m, 1H), 3.21 (t, J=8.0 Hz, 2H), 2.86-2.82 (m, 4H), 2.68 (s, 3H), 2.63-2.61 (m, 1H), 2.60-2.58 (m, 1H), 2.42-2.39 (m, 1H), 2.32-2.29 (m, 3H), 2.22-2.16 (m, 1H), 1.95-1.85 (m, 6H), 1.64-1.61 (m, 5H), 1.49-1.40 (m, 6H). LC/MS (ESI) calcd for C₂₉H₄₀N₅O₃⁺ [M+H]⁺, 506.67; found, 506.8.

Example 12: Preparation of 3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02495)

Following the method of Scheme 1 and the method of Example 6, under appropriate conditions understood in the field, the target compound GT-02495 was prepared (pale yellow solid, 54 mg, yield 67%). ¹H NMR (400 MHz, DMSO) δ 11.03 (s, 1H), 8.94 (brs, 2H), 7.53 (t, J=8.0 Hz, 1H), 6.69 (d, J=8.0 Hz, 1H), 6.56 (d, J=8.0 Hz, 1H), 5.25-5.20 (m, 1H), 3.18 (t, J=8.0 Hz, 2H), 2.90-2.80 (m, 3H), 2.69-2.67 (m, 1H), 2.65-2.63 (m, 1H), 2.61 (s, 3H), 2.60-2.57 (m, 1H), 2.40-2.37 (m, 1H), 2.34-2.28 (m, 3H), 2.21-2.14 (m, 1H), 1.94-1.84 (m, 7H), 1.67-1.58 (m, 6H), 1.41-1.34 (m, 6H). LC/MS (ESI) calcd for C₃₀H₄₂N₅O₃⁺ [M+H]⁺, 520.69; found, 520.8.

Example 13: Preparation of 3-(2-methyl-5-((7-(4-methyl-1,4-diazepan-1-yl)heptyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02502)

Following the method of Scheme 1 and the method of Example 6, under appropriate conditions understood in the field, the target compound GT-02502 was prepared (pale yellow solid, 15 mg, yield 45%). LC/MS (ESI) calcd for C₂₅H₃₇N₆O₃⁺ [M+H]⁺, 469.61; found, 469.6.

Example 14: Preparation of 3-(5-(((1s,3s)-adamantan-1-yl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02601)

Following the method of Scheme 1 and the method of Example 6, under appropriate conditions understood in the field, the target compound GT-02601 was prepared (white solid, 10 mg, yield 46%). LC/MS (ESI) calcd for C₂₄H₂₉N₄O₃⁺ [M+H]⁺, 421.52; found, 421.5.

Example 15: Preparation of 3-(5-((7-hydroxyheptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02598)

Following the method of Scheme 2, under appropriate conditions understood in the field, the target compound GT-02598 was prepared (pale yellow solid, 280 mg, yield 40%). LC/MS (ESI) calcd for C₂₁H₂₉N₄O₄⁺ [M+H]⁺, 401.22; found, 401.3.

Example 16: Preparation of 3-(5-((2-(2-hydroxyethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02607)

Following the method of Scheme 3, under appropriate conditions understood in the field, the target compound GT-02607 was prepared (pale yellow solid, 1.1 g, yield 58%). LC/MS (ESI) calcd for C₁₈H₂₃N₄O₅⁺ [M+H]⁺, 375.17; found, 375.2.

Example 17: Preparation of 3-(5-((2-(2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02608)

Following the method of Scheme 3, under appropriate conditions understood in the field, the target compound GT-02608 was prepared (pale yellow solid, 11 mg, yield 46%). ¹H NMR (400 MHz, DMSO) δ 11.04 (s, 1H), 9.78 (brs, 1H), 7.55 (t, J=8.0 Hz, 1H), 6.74 (d, J=8.0 Hz, 1H), 6.64 (d, J=8.0 Hz, 1H), 5.27-5.23 (m, 1H), 3.85-3.80 (m, 4H), 3.72-3.68 (m, 3H), 3.18-3.08 (m, 2H), 3.03-2.97 (m, 1H), 2.87-2.83 (m, 2H), 2.71-2.69 (m, 1H), 2.64 (s, 3H), 2.34-2.69 (m, 1H), 2.30-2.28 (m, 1H), 2.20-2.16 (m, 2H), 1.94-1.89 (m, 1H), 1.86-1.75 (m, 1H), 1.30-1.26 (m, 1H). LC/MS (ESI) calcd for C₂₃H₃₀N₅O₅⁺ [M+H]⁺, 456.22; found, 456.2.

Example 18: Preparation of 3-(2-methyl-5-((2-(2-morpholinoethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02617)

Following the method of Scheme 3, under appropriate conditions understood in the field, the target compound GT-02617 was prepared (pale yellow solid, 5 mg, yield 23%). ¹H NMR (400 MHz, DMSO) δ 11.09 (s, 1H), 10.91 (s, 1H), 7.60 (t, J=8.8 Hz, 1H), 6.82 (d, J=8.8 Hz, 1H), 6.71 (d, J=8.8 Hz, 1H), 5.32-5.27 (m, 1H), 3.77-3.69 (m, 6H), 3.46-3.38 (m, 4H), 3.18-3.01 (m, 4H), 2.88-2.92 (m, 2H), 2.66-2.56 (m, 2H), 2.52 (s, 3H), 2.27-2.14 (m, 2H). LC/MS (ESI) calcd for C₂₂H₃₀N₅O₅⁺ [M+H]⁺, 444.22; found, 444.2.

Example 19: Preparation of 3-(2-methyl-5-((2-(2-(4-morpholinopiperidin-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02618)

Following the method of Scheme 3, under appropriate conditions understood in the field, the target compound GT-02618 was prepared (pale yellow solid, 10 mg, yield 38%). ¹H NMR (400 MHz, DMSO) δ 11.15 (s, 1H), 10.67 (s, 1H), 7.63 (t, J=8.0 Hz, 1H), 6.88 (d, J=8.0 Hz, 1H), 6.76 (d, J=8.0 Hz, 1H), 5.35-5.31 (m, 1H), 4.04-3.82 (m, 6H), 3.50-3.35 (m, 8H), 3.16-2.93 (m, 6H), 2.87-2.84 (m, 1H), 2.64-2.61 (m, 2H), 2.52 (s, 3H), 2.40-2.24 (m, 3H), 2.14-2.10 (m, 2H). LC/MS (ESI) calcd for C₂₇H₃₉N₆O₅⁺ [M+H]⁺, 527.30; found, 527.3.

Example 20: Preparation of 3-(2-methyl-5-((2-(2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02619)

Following the method of Scheme 3, under appropriate conditions understood in the field, the target compound GT-02619 was prepared (pale yellow solid, 10 mg, yield 35%). ¹H NMR (400 MHz, DMSO) δ 11.08 (s, 1H), 10.37 (brs, 1H), 8.40 br (s, 1H), 7.56 (t, J=8.0 Hz, 1H), 6.75 (d, J=8.0 Hz, 1H), 6.65 (d, J=8.0 Hz, 1H), 5.28-5.24 (m, 1H), 3.84-3.82 (m, 2H), 3.71-3.69 (m, 3H), 3.63-3.60 (m, 5H), 3.33-3.27 (m, 6H), 2.98-2.95 (m, 3H), 2.86-2.85 (m, 1H), 2.82 (s, 3H), 2.68-2.65 (m, 1H), 2.65 (s, 3H), 2.62-2.60 (m, 2H), 2.27-2.20 (m, 3H), 2.08-1.96 (m, 2H), 1.31-1.26 (m, 1H). LC/MS (ESI) calcd for C₂₈H₄₂N₇O₄⁺ [M+H]⁺, 540.33; found, 540.3.

Example 21: Preparation of 3-(2-methyl-5-((2-(2-(4-(oxetan-3-yl)piperazin-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02620)

Following the method of Scheme 3, under appropriate conditions understood in the field, the target compound GT-02620 was prepared (pale yellow solid, 8 mg, yield 32%). ¹H NMR (400 MHz, DMSO) δ 11.14 (s, 1H), 7.63 (t, J=8.0 Hz, 1H), 6.88 (d, J=8.0 Hz, 1H), 6.77 (d, J=8.0 Hz, 1H), 5.36-5.31 (m, 1H), 4.49-4.44 (m, 1H), 3.90-3.86 (m, 4H), 3.51-3.47 (m, 6H), 3.42-3.38 (m, 4H), 3.32-3.29 (m, 2H), 2.91-2.86 (m, 1H), 2.79 (s, 3H), 2.70 (s, 1H), 2.68-2.64 (m, 1H), 2.64-2.61 (m, 1H), 2.25-2.16 (m, 2H), 1.94-1.89 (m, 1H), 1.32-1.26 (m, 1H). LC/MS (ESI) calcd for C₂₅H₃₅N₆O₅⁺ [M+H]⁺, 499.27; found, 499.3.

Example 22: Preparation of 3-(5-((7-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02621)

Following the method of Scheme 2, under appropriate conditions understood in the field, the target compound GT-02621 was prepared (pale yellow solid, 10 mg, yield 46%). ¹H NMR (400 MHz, DMSO) δ 11.05 (s, 1H), 7.55 (t, J=8.0 Hz, 1H), 6.71 (d, J=8.0 Hz, 1H), 6.58 (t, J=8.0 Hz, 1H), 5.26-5.22 (m, 1H), 4.59 (d, J=8.0 Hz, 1H), 3.70-3.62 (m, 3H), 3.21-3.17 (m, 5H), 3.08-3.06 (m, 2H), 2.87-2.84 (m, 2H), 2.67-2.61 (m, 5H), 2.59-2.57 (m, 1H), 2.36-2.26 (m, 1H), 2.19-2.14 (m, 1H), 1.70-1.54 (m, 3H), 1.40-1.27 (m, 6H). LC/MS (ESI) calcd for C₂₆H₃₆N₅O₄⁺ [M+H]⁺, 482.28; found, 482.3.

Example 23: Preparation of 3-(2-methyl-5-((7-(4-morpholinopiperidin-1-yl)heptyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02622)

Following the method of Scheme 2, under appropriate conditions understood in the field, the target compound GT-02622 was prepared (pale yellow solid, 14 mg, yield 57%). ¹H NMR (400 MHz, DMSO) δ 11.58 (brs, 1H), 11.09 (s, 1H), 10.58 (brs, 1H), 7.59 (t, J=8.0 Hz, 1H), 6.79 (d, J=8.0 Hz, 1H), 6.63 (d, J=8.0 Hz, 1H), 5.31-5.27 (m, 1H), 4.02-3.97 (m, 3H), 3.91-3.85 (m, 3H), 3.22-3.19 (m, 3H), 3.14-3.07 (m, 3H), 2.94-2.83 (m, 3H), 2.72 (s, 3H), 2.67-2.56 (m, 2H), 2.35-2.32 (m, 2H), 2.22-2.12 (m, 3H), 1.75-1.56 (m, 5H), 1.41-1.24 (m, 8H). LC/MS (ESI) calcd for C₃₀H₄₅N₆O₄⁺ [M+H]⁺, 553.35; found, 553.4.

Example 23: Preparation of 3-(2-methyl-5-((7-(4-(oxetan-3-yl)piperazin-1-yl)heptyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02623)

Following the method of Scheme 2, under appropriate conditions understood in the field, the target compound GT-02623 was prepared (pale yellow solid, 8 mg, yield 32%). ¹H NMR (400 MHz, DMSO) δ 11.09 (s, 1H), 7.58 (t, J=8.0 Hz, 1H), 6.77 (d, J=8.0 Hz, 1H), 6.63 (d, J=8.0 Hz, 1H), 5.30-5.26 (m, 1H), 4.69-4.61 (m, 2H), 3.77-3.67 (m, 5H), 3.26-3.14 (m, 5H), 3.11-3.05 (m, 3H), 2.92-2.83 (m, 2H), 2.71 (s, 3H), 2.64-2.62 (m, 1H), 2.59-2.57 (m, 1H), 2.25-2.13 (m, 1H), 1.74-1.58 (m, 4H), 1.42-1.23 (m, 7H). LC/MS (ESI) calcd for C₂₈H₄₁N₆O₄⁺ [M+H]⁺, 525.32; found, 525.3.

Example 24: Preparation of 3-(5-((7-hydroxyheptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02663)

Following the method of Scheme 4, under appropriate conditions understood in the field, the target compound GT-02663 was prepared (pale yellow solid, 14 mg, yield 36%). LC/MS (ESI) calcd for C₂₁H₂₈N₃O₅⁺ [M+H]⁺, 402.20; found, 402.2.

Example 25: Preparation of 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02769)

Following the method of Scheme 4, under appropriate conditions understood in the field, the target compound GT-02769 was prepared (pale yellow solid, 12 mg, yield 54%). ¹H NMR (400 MHz, DMSO) δ 10.98 (s, 1H), 8.30 (brs, 2H), 7.67 (t, J=8.0 Hz, 1H), 7.11 (d, J=8.0 Hz, 1H), 6.99 (d, J=8.0 Hz, 1H), 5.17-5.15 (m, 1H), 4.08-4.01 (m, 2H), 2.90-2.81 (m, 4H), 2.59 (s, 3H), 2.14-2.09 (m, 5H), 1.85-1.80 (m, 6H), 1.69-1.64 (m, 4H), 1.50-1.44 (m, 2H), 1.40-1.36 (m, 6H), 1.24-1.20 (m, 4H). LC/MS (ESI) calcd for C₃₁H₄₃N₄O₄⁺ [M+H]⁺, 535.33; found, 535.3.

Example 26: Preparation of 3-(2-methyl-5-((7-(4-(oxetan-3-yl)piperazin-1-yl)heptyl)oxy)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02770)

Following the method of Scheme 4, under appropriate conditions understood in the field, the target compound GT-02770 was prepared (white solid, 13 mg, yield 59%). LC/MS (ESI) calcd for C₂₈H₄₀N₅O₅⁺ [M+H]⁺, 526.30; found, 526.3.

Example 27: Preparation of 3-(2-methyl-5-((7-(4-methylpiperazin-1-yl)heptyl)oxy)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02771)

Following the method of Scheme 4, under appropriate conditions understood in the field, the target compound GT-02771 was prepared (white solid, 10 mg, yield 49%). LC/MS (ESI) calcd for C₂₆H₃₈N₅O₄⁺ [M+H]⁺, 484.29; found, 484.3.

Example 28: Preparation of 3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02767)

Following the method of Scheme 1, under appropriate conditions understood in the field, the target compound GT-02767 was prepared (white solid, 15 mg, yield 38%). ¹H NMR (400 MHz, DMSO) δ 11.01 (s, 1H), 8.41 (brs, 2H), 7.50 (t, J=8.0 Hz, 1H), 6.65 (d, J=8.0 Hz, 1H), 6.52 (d, J=8.0 Hz, 1H), 5.22-5.18 (m, 1H), 3.21-3.14 (m, 3H), 2.91-2.80 (m, 4H), 2.57 (s, 3H), 2.56 (s, 2H), 2.54 (s, 3H), 2.34-2.33 (m, 2H), 2.22-2.17 (m, 3H), 1.71-1.69 (m, 3H), 1.65-1.56 (m, 4H), 1.20-1.09 (m, 5H), 0.87 (brs, 9H). LC/MS (ESI) calcd for C₃₃H₄₈N₅O₃⁺ [M+H]⁺, 562.38; found, 562.4.

Example 29: Preparation of 3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02768)

Following the method of Scheme 1, under appropriate conditions understood in the field, the target compound GT-02768 was prepared (white solid, 23 mg, yield 58%). H NMR (400 MHz, DMSO) δ 10.93 (s, 1H), 8.24 (brs, 2H), 7.43 (t, J=8.0 Hz, 1H), 7.27 (brs, 1H), 6.58 (d, J=8.0 Hz, 1H), 6.44 (d, J=8.0 Hz, 1H), 5.15-5.11 (m, 1H), 3.13-3.06 (m, 4H), 2.95-2.77 (m, 5H), 2.70-2.65 (m, 2H), 2.61-2.60 (m, 1H), 2.49 (s, 3H), 2.28-2.25 (m, 1H), 2.15-2.05 (m, 2H), 1.95-1.92 (m, 3H), 1.61-1.55 (m, 5H), 1.48-1.40 (m, 5H), 1.36-1.25 (m, 6H), 1.09-1.02 (m, 4H). LC/MS (ESI) calcd for C₃₃H₄₈N₅O₃⁺ [M+H]⁺, 562.38; found, 562.4.

Example 30: Preparation of 3-(5-((7-(3-azabicyclo[3.1.0]hexan-3-yl)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02772)

Following the method of Scheme 1, under appropriate conditions understood in the field, the target compound GT-02772 was prepared (white solid, 15 mg, yield 47%). H NMR (400 MHz, DMSO) δ 11.02 (s, 1H), 10.04 (brs, 1H), 8.29 br (s, 1H), 7.52 (t, J=8.0 Hz, 1H), 6.67 (d, J=8.0 Hz, 1H), 6.54 (d, J=8.0 Hz, 1H), 5.23-5.19 (m, 1H), 3.54-3.50 (m, 2H), 3.23-3.15 (m, 5H), 3.07-3.02 (m, 2H), 2.86-2.82 (m, 1H), 2.72-2.67 (m, 1H), 2.63-2.58 (m, 5H), 2.19-2.14 (m, 1H), 1.76-1.70 (m, 2H), 1.64-1.57 (m, 4H), 1.40-1.34 (m, 4H), 0.92-0.88 (m, 1H), 0.67-0.61 (m, 1H). LC/MS (ESI) calcd for C₂₆H₃₆N₅O₃⁺ [M+H]⁺, 466.28; found, 466.3.

Example 31: Preparation of 3-(5-((7-(2,2-difluoro-7-azaspiro[3.5]nonan-7-yl)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02773)

Following the method of Scheme 1, under appropriate conditions understood in the field, the target compound GT-02773 was prepared (white solid, 13 mg, yield 34%). H NMR (400 MHz, DMSO) δ 11.04 (s, 1H), 9.99 (brs, 1H), 7.54 (t, J=8.0 Hz, 1H), 6.70 (d, J=8.0 Hz, 1H), 6.57 (d, J=8.0 Hz, 1H), 5.26-5.21 (m, 1H), 3.34-3.29 (m, 5H), 3.20-3.16 (m, 3H), 3.01-2.97 (m, 3H), 2.88-2.82 (m, 4H), 2.63 (s, 3H), 2.59-2.54 (m, 2H), 2.20-2.16 (m, 1H), 1.98-1.92 (m, 2H), 1.82-1.79 (m, 3H), 1.67-1.58 (m, 5H), 1.53-1.50 (m, 1H). LC/MS (ESI) calcd for C₂₉H₄₀F₂N₅O₃⁺ [M+H]⁺, 544.31; found, 544.3.

Example 32: Preparation of 3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02774)

Following the method of Scheme 1, under appropriate conditions understood in the field, the target compound GT-02774 was prepared (white solid, 15 mg, yield 41%). H NMR (400 MHz, DMSO) δ 11.01 (s, 1H), 8.61 (brs, 2H), 7.51 (t, J=8.0 Hz, 1H), 6.66 (d, J=8.0 Hz, 1H), 6.53 (d, J=8.0 Hz, 1H), 5.23-5.20 (m, 1H), 3.21-3.15 (m, 4H), 2.89-2.81 (m, 4H), 2.68-2.64 (m, 2H), 2.58 (s, 3H), 2.34-2.32 (m, 1H), 2.20-2.13 (m, 2H), 1.99-1.95 (m, 6H), 1.64-1.56 (m, 6H), 1.29-1.24 (m, 5H). LC/MS (ESI) calcd for C₂₉H₄₁FN₅O₃⁺ [M+H]⁺, 526.31; found, 526.3.

Example 33: Preparation of 3-(5-(5-(((3s,5s,7s)-adamantan-1-yl)amino)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02632)

The target compound 3-(5-(5-(((3s,5s,7s)-adamantan-1-yl)amino)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02632) was prepared by referring to the method of step 4 of Scheme 5.

5-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)pent-4-yn-1-yl methanesulfonate (729092) (1 eq.) and adamantaneamine (2 eq.) were added into a 10 mL reaction flask, followed by the addition of NMP (1 mL), and then under nitrogen protection, sodium iodide (1.5 eq.) and DIPEA (3 eq.). After the addition was complete, the mixture was heated to 85° C. and stirred for 3 hours. After monitoring the reaction via LCMS and confirming its completion, the reaction mixture was subjected to preparative HPLC (0.05% HCl aq./acetonitrile) to give the target compound (GT-02632) (pale yellow solid, 10.0 mg, yield 39.5%). ¹H NMR (400 MHz, MeOD) δ 7.89 (t, J=7.9 Hz, 1H), 7.69 (dd, J=23.7, 7.9 Hz, 2H), 5.41 (dd, J=11.1, 5.9 Hz, 1H), 3.30-3.23 (m, 3H), 3.03-2.82 (m, 5H), 2.75 (t, J=6.8 Hz, 2H), 2.33 (d, J=5.7 Hz, 1H), 2.23 (s, 3H), 2.02 (dd, J=14.4, 7.0 Hz, 2H), 1.95 (s, 6H), 1.78 (dd, J=31.3, 12.6 Hz, 6H). LCMS (ESI) calcd for C₂₉H₃₅N₄O₃⁺ [M+H]⁺, 487.27; found, 487.3.

Example 34: Preparation of 3-(2-methyl-4-oxo-5-(5-(piperidin-1-yl)pent-1-yn-1-yl)quinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02633)

Following the method of Scheme 5 and the method of example 33, under appropriate conditions understood in the field, the target compound GT-02633 was prepared (pale yellow solid, 10.0 mg, yield 39.5%). ¹H NMR (400 MHz, MeOD) δ 7.80 (t, J=7.9 Hz, 1H), 7.68-7.57 (m, 2H), 5.36 (dd, J=11.2, 5.9 Hz, 1H), 3.60 (d, J=11.6 Hz, 2H), 3.51 (dd, J=9.0, 7.0 Hz, 2H), 3.16 (s, 1H), 2.93 (dd, J=22.1, 10.6 Hz, 4H), 2.82-2.70 (m, 5H), 2.30 (d, J=4.9 Hz, 1H), 2.11-1.98 (m, 4H), 1.91-1.73 (m, 4H). LCMS (ESI) calcd for C₂₄H₂₉N₄O₃⁺ [M+H]⁺, 421.22; found, 421.2.

Example 35: Preparation of 3-(2-methyl-5-(5-(4-methylpiperazin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02634)

Following the method of Scheme 5 and the method of example 33, under appropriate conditions understood in the field, the target compound GT-02634 was prepared (pale yellow solid, 6.0 mg, yield 35.38%). ¹H NMR (400 MHz, MeOD) δ 7.88 (t, J=7.9 Hz, 1H), 7.69 (dd, J=25.3, 7.8 Hz, 2H), 5.42 (d, J=10.1 Hz, 1H), 3.63 (dd, J=16.1, 8.1 Hz, 11H), 3.05 (s, 3H), 2.92 (ddd, J=29.2, 15.3, 10.3 Hz, 5H), 2.77 (t, J=6.5 Hz, 2H), 2.37-2.27 (m, 1H), 2.18 (dd, J=14.1, 7.2 Hz, 2H). LCMS (ESI) calcd for C₂₄H₃₀N₅O₃⁺ [M+H]⁺, 436.23; found, 436.2.

Example 36: Preparation of 3-(2-methyl-5-(5-(4-(oxetan-3-yl)piperazin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02635)

Following the method of Scheme 5 and the method of example 33, under appropriate conditions understood in the field, the target compound GT-02635 was prepared (pale yellow solid, 8.0 mg, yield 39.96%). ¹H NMR (400 MHz, MeOD) δ 7.88 (t, J=8.0 Hz, 1H), 7.69 (dd, J=20.8, 7.8 Hz, 2H), 5.45 (d, J=5.6 Hz, 1H), 4.86-4.70 (m, 4H), 3.97-3.41 (m, 8H), 3.18 (d, J=21.6 Hz, 3H), 3.04-2.51 (m, 8H), 2.36 (d, J=10.3 Hz, 1H), 2.11 (s, 2H). LCMS (ESI) calcd for C₂₆H₃₂N₅O₄⁺ [M+H]⁺, 478.24; found, 478.2.

Example 37: Preparation of 3-(2-methyl-5-(5-(4-methyl-1,4-diazepan-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02636)

Following the method of Scheme 5 and the method of example 33, under appropriate conditions understood in the field, the target compound GT-02636 was prepared (pale yellow solid, 3.0 mg, yield 15.02%). LCMS (ESI) calcd for C₂₅H₃₂N₅O₃⁺ [M+H]⁺, 450.25; found, 450.3.

Example 38: Preparation of 3-(5-(5-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02815)

Following the method of Scheme 5 and the method of example 33, under appropriate conditions understood in the field, the target compound GT-02815 was prepared (pale yellow solid, 9.0 mg, yield 39.47%). ¹H NMR (400 MHz, DMSO) δ 11.00 (d, J=11.6 Hz, 1H), 7.81-7.67 (m, 1H), 7.64-7.51 (m, 2H), 5.26 (d, J=6.1 Hz, 1H), 4.61 (s, 1H), 3.76-3.69 (m, 1H), 3.53 (s, 1H), 3.30 (d, J=7.1 Hz, 2H), 3.18 (d, J=9.9 Hz, 2H), 2.92-2.81 (m, 1H), 2.75-2.56 (m, 8H), 2.44 (d, J=9.9 Hz, 1H), 2.22-2.12 (m, 2H), 2.12-1.99 (m, 2H). LCMS (ESI) calcd for C₂₄H₂₇N₄O₄⁺ [M+H]⁺, 435.20; found, 435.2.

Example 39: Preparation of 3-(2-methyl-5-(5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02816)

Following the method of Scheme 5 and the method of example 33, under appropriate conditions understood in the field, the target compound GT-02816 was prepared (pale yellow solid, 5.0 mg, yield 18.07%). ¹H NMR (400 MHz, DMSO) δ 11.11 (s, 1H), 10.41 (s, 1H), 7.81-7.68 (m, 1H), 7.63-7.48 (m, 2H), 5.30 (dd, J=11.6, 5.6 Hz, 1H), 3.65 (s, 8H), 2.82 (s, 8H), 2.73-2.58 (m, 9H), 2.11 (dd, J=68.3, 5.7 Hz, 8H). LCMS (ESI) calcd for C₂₉H₃₉N₆O₃⁺ [M+H]⁺, 519.31; found, 519.3.

Example 40: Preparation of 3-(2-methyl-5-(5-(4-morpholinopiperidin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02817)

Following the method of Scheme 5 and the method of example 33, under appropriate conditions understood in the field, the target compound GT-02817 was prepared (pale yellow solid, 8.0 mg, yield 30.48%). ¹H NMR (400 MHz, DMSO) δ 11.53 (s, 1H), 11.09 (d, J=25.4 Hz, 1H), 10.74 (s, 1H), 7.78-7.72 (m, 1H), 7.57 (dd, J=16.7, 7.8 Hz, 2H), 5.31 (dd, J=11.7, 5.4 Hz, 1H), 4.00 (s, 2H), 3.89 (d, J=11.5 Hz, 2H), 3.69 (d, J=11.4 Hz, 2H), 3.37-3.32 (m, 2H), 3.08 (s, 4H), 2.86 (s, 4H), 2.71-2.61 (m, 9H), 2.35 (d, J=11.4 Hz, 1H), 2.17 (d, J=8.7 Hz, 2H), 2.02 (s, 2H). LCMS (ESI) calcd for C₂₈H₃₆N₅O₄⁺[M+H]⁺, 506.28; found, 506.3.

Example 41: Preparation of 3-(5-(5-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02818)

Following the method of Scheme 5 and the method of example 33, under appropriate conditions understood in the field, the target compound GT-02818 was prepared (pale yellow solid, 9.0 mg, yield 33.37%). ¹H NMR (400 MHz, DMSO) δ 10.93 (s, 1H), 8.38 (s, 1H), 7.74-7.64 (m, 1H), 7.52-7.45 (m, 2H), 5.19 (dd, J=11.3, 5.2 Hz, 1H), 3.21-3.10 (m, 1H), 3.04 (s, 1H), 2.89-2.74 (m, 1H), 2.72-2.65 (m, 1H), 2.65-2.53 (m, 7H), 2.10 (d, J=6.8 Hz, 1H), 2.01-1.81 (m, 5H), 1.57 (t, J=12.3 Hz, 9H), 1.44 (d, J=11.5 Hz, 3H), 1.07 (d, J=12.4 Hz, 3H). LCMS (ESI) calcd for C₃₁H₃₉N₄O₃⁺ [M+H]⁺, 515.30; found, 515.3.

Example 42: Preparation of 3-(5-(8-(((3s,5s,7s)-adamantan-1-yl)amino)oct-1-yn-1-yl))-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02638)

The target compound 3-(5-(8-(((3s,5s,7s)-adamantan-1-yl)amino)oct-1-yn-1-yl))-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02638) was prepared by referring to the method of step 4 of Scheme 5 and the method of example 33.

8-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)oct-7-yn-1-yl methanesulfonate (n=6: 729101) (1 eq.) and adamantaneamine (2 eq.) were added into a 10 mL reaction flask, followed by the addition of NMP (1 mL), and then under nitrogen protection, sodium iodide (1.5 eq.) and DIPEA (3 eq.). After the addition was complete, the mixture was heated to 85° C. and stirred for 3 hours. After monitoring the reaction via LCMS and confirming its completion, the reaction mixture was subjected to preparative HPLC (0.05% HCl aq./acetonitrile) to give the target compound (GT-02638) (pale yellow solid, 8.0 mg, yield 35.39%). ¹H NMR (400 MHz, MeOD) δ 7.87 (t, J=8.0 Hz, 1H), 7.65 (dd, J=25.1, 7.3 Hz, 2H), 5.46-5.33 (m, 1H), 3.10-2.69 (m, 8H), 2.57 (d, J=6.1 Hz, 2H), 2.37-2.28 (m, 1H), 2.20 (s, 3H), 1.92 (d, J=2.2 Hz, 6H), 1.84-1.66 (m, 12H), 1.52 (d, J=7.9 Hz, 2H). LCMS (ESI) calcd for C₃₂H₄₁N₄O₃⁺ [M+H]⁺, 529.32; found, 529.3.

Example 43: Preparation of 3-(2-methyl-5-(8-(4-(oxetan-3-yl)piperazin-1-yl)oct-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02639)

Following the method of Scheme 5 and the method of example 42, under appropriate conditions understood in the field, the target compound GT-02639 was prepared (pale yellow solid, 9.0 mg, yield 40.46%). ¹H NMR (400 MHz, MeOD) δ 7.79 (t, J=8.0 Hz, 1H), 7.57 (dd, J=31.0, 7.9 Hz, 2H), 5.32 (dd, J=11.3, 5.8 Hz, 1H), 4.75-4.50 (m, 4H), 4.29-3.27 (m, 9H), 3.16-3.10 (m, 2H), 2.90-2.64 (m, 6H), 2.46 (s, 2H), 2.29-2.15 (m, 1H), 1.70 (dd, J=11.8, 7.9 Hz, 2H), 1.59 (s, 4H), 1.38 (d, J=7.1 Hz, 2H). LCMS (ESI) calcd for C₂₉H₃₈N₅O₄⁺ [M+H]+, 520.29; found, 520.3.

Example 44: Preparation of 3-(2-methyl-5-(8-(4-methylpiperazin-1-yl)oct-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02645)

Following the method of Scheme 5 and the method of example 42, under appropriate conditions understood in the field, the target compound GT-02645 was prepared (pale yellow solid, 9.0 mg, yield 43.77%). ¹H NMR (400 MHz, MeOD) δ 7.87 (t, J=7.9 Hz, 1H), 7.66 (dd, J=23.2, 7.8 Hz, 2H), 5.40 (dd, J=11.4, 5.8 Hz, 1H), 3.75 (tt, J=13.2, 6.7 Hz, 8H), 3.27 (d, J=7.4 Hz, 2H), 3.04 (s, 3H), 3.02-2.65 (m, 6H), 2.57 (s, 2H), 2.34 (d, J=5.5 Hz, 1H), 1.85 (dd, J=19.6, 12.3 Hz, 2H), 1.70 (s, 4H), 1.50 (s, 2H). LCMS (ESI) calcd for C₂₇H₃₆N₅O₃+[M+H]⁺, 478.28; found, 478.3.

Example 45: Preparation of 3-(2-methyl-5-(8-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)oct-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02653)

Following the method of Scheme 5 and the method of example 42, under appropriate conditions understood in the field, the target compound GT-02653 was prepared (pale yellow solid, 15.0 mg, yield 62.79%). ¹H NMR (400 MHz, MeOD) δ 7.93 (t, J=8.0 Hz, 1H), 7.70 (dd, J=32.8, 7.5 Hz, 2H), 5.53-5.36 (m, 1H), 4.04-3.41 (m, 12H), 3.22-3.06 (m, 4H), 3.06-2.88 (m, 6H), 2.82 (dd, J=21.2, 13.6 Hz, 2H), 2.57 (d, J=5.6 Hz, 2H), 2.51-2.31 (m, 3H), 2.24-2.08 (m, 2H), 1.78 (dd, J=17.2, 9.3 Hz, 2H), 1.70 (s, 4H), 1.48 (d, J=7.3 Hz, 2H). LCMS (ESI) calcd for C₃₂H₄₅N₆O₃⁺ [M+H]⁺, 561.35; found, 561.4.

Example 46: Preparation of 3-(5-(8-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02654)

Following the method of Scheme 5 and the method of example 42, under appropriate conditions understood in the field, the target compound GT-02654 was prepared (pale yellow solid, 10.0 mg, yield 48.73%). ¹H NMR (400 MHz, MeOD) δ 7.75 (t, J=8.0 Hz, 1H), 7.62-7.45 (m, 2H), 5.29 (d, J=11.6 Hz, 1H), 4.55 (d, J=6.5 Hz, 2H), 3.72 (dt, J=34.6, 17.3 Hz, 2H), 3.52-3.34 (m, 2H), 3.29 (dd, J=20.1, 9.6 Hz, 2H), 3.04 (dd, J=19.9, 11.4 Hz, 2H), 2.92-2.56 (m, 6H), 2.47 (s, 2H), 2.21 (dd, J=13.0, 8.9 Hz, 1H), 1.80-1.68 (m, 2H), 1.59 (s, 4H), 1.40 (s, 2H). LCMS (ESI) calcd for C₂₇H₃₃N₄O₄⁺[M+H]⁺, 477.25; found, 477.3.

Example 47: Preparation of 3-(5-(5-(((3s,5s,7s)-adamantan-1-yl)amino)pentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02759)

The target compound 3-(5-(5-(((3s,5s,7s)-adamantan-1-yl)amino)pentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02759) was prepared by referring to the method of step 3 of Scheme 6.

5-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)pentyl methanesulfonate (729109) (1 eq.) and adamantaneamine (2 eq.) were added into a 10 mL reaction flask, followed by the addition of NMP (1 mL), and then under nitrogen protection, sodium iodide (1.5 eq.) and DIPEA (3 eq.). After the addition was complete, the mixture was heated to 85° C. and stirred for 3 hours. After monitoring the reaction via LCMS and confirming its completion, the reaction mixture was subjected to preparative HPLC (0.05% HCl aq./acetonitrile) to give the target compound GT-02759 (pale yellow solid, 9.0 mg, yield 35.26%). ¹H NMR (400 MHz, MeOD) δ 7.75 (t, J=7.9 Hz, 1H), 7.47 (d, J=7.3 Hz, 1H), 7.39 (d, J=7.4 Hz, 1H), 5.27 (dd, J=11.1, 5.8 Hz, 1H), 3.25 (d, J=12.3 Hz, 1H), 3.09 (dt, J=16.5, 8.7 Hz, 1H), 2.97-2.81 (m, 3H), 2.79 (s, 3H), 2.75-2.60 (m, 2H), 2.22 (t, J=7.6 Hz, 1H), 2.11 (s, 3H), 1.81 (d, J=2.4 Hz, 7H), 1.61 (ddd, J=24.7, 22.5, 10.3 Hz, 11H), 1.49-1.37 (m, 2H). LCMS (ESI) calcd for C₂₉H₃₉N₄O₃⁺ [M+H]⁺, 491.30; found, 491.3.

Example 48: Preparation of 3-(2-methyl-5-(5-(4-(oxetan-3-yl)piperazin-1-yl)pentyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02761)

Following the method of Scheme 6 and the method of example 47, under appropriate conditions understood in the field, the target compound GT-02761 was prepared (pale yellow solid, 10.0 mg, yield 39.86%). ¹H NMR (400 MHz, MeOD) δ 7.95 (t, J=7.9 Hz, 1H), 7.64 (dd, J=14.6, 7.9 Hz, 2H), 5.47 (dd, J=11.3, 5.8 Hz, 1H), 4.87-4.73 (m, 3H), 4.31 (ddd, J=95.3, 10.4, 5.1 Hz, 1H), 3.90-3.35 (m, 10H), 3.31-3.23 (m, 2H), 3.22-3.14 (m, 1H), 3.02 (d, J=5.1 Hz, 3H), 2.99-2.78 (m, 3H), 2.43-2.28 (m, 1H), 1.90 (dt, J=15.6, 7.7 Hz, 2H), 1.68 (tt, J=14.1, 7.2 Hz, 2H), 1.62-1.47 (m, 2H). LCMS (ESI) calcd for C₂₆H₃₆N₅O₄⁺ [M+H]⁺, 482.28; found, 482.3.

Example 49: Preparation of 3-(5-(5-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)pentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02762)

Following the method of Scheme 6 and the method of example 47, under appropriate conditions understood in the field, the target compound GT-02762 was prepared (pale yellow solid, 9.0 mg, yield 39.13%). ¹H NMR (400 MHz, MeOD) δ 7.87 (td, J=7.9, 4.1 Hz, 1H), 7.60 (d, J=8.2 Hz, 1H), 7.52 (t, J=7.8 Hz, 1H), 5.40 (dd, J=11.0, 5.8 Hz, 1H), 4.80-4.21 (m, 2H), 3.88-3.70 (m, 1H), 3.65-3.34 (m, 4H), 3.18 (ddd, J=28.5, 24.2, 20.0 Hz, 4H), 3.01-2.73 (m, 6H), 2.50-2.26 (m, 2H), 1.90 (ddd, J=37.8, 19.2, 7.2 Hz, 2H), 1.74-1.45 (m, 4H). LCMS (ESI) calcd for C₂₄H₃₁N₄O₄⁺ [M+H]⁺, 439.23; found, 439.2.

Example 50: Preparation of 3-(2-methyl-5-(5-(4-methylpiperazin-1-yl)pentyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02763)

Following the method of Scheme 6 and the method of example 47, under appropriate conditions understood in the field, the target compound GT-02763 was prepared (pale yellow solid, 9.0 mg, yield 38.22%). ¹H NMR (400 MHz, MeOD) δ 7.94 (t, J=7.9 Hz, 1H), 7.69-7.54 (m, 2H), 5.45 (dd, J=11.0, 5.7 Hz, 1H), 3.71 (dd, J=64.5, 18.1 Hz, 8H), 3.45-3.34 (m, 2H), 3.31 (d, J=12.5 Hz, 2H), 3.17 (ddd, J=12.5, 9.4, 6.3 Hz, 1H), 3.04 (d, J=3.9 Hz, 3H), 3.02-2.78 (m, 5H), 2.44-2.28 (m, 1H), 1.99-1.83 (m, 2H), 1.76-1.62 (m, 2H), 1.56 (dd, J=14.7, 7.2 Hz, 2H). LCMS (ESI) calcd for C₂₄H₃₄N₅O₃⁺ [M+H]⁺, 440.27; found, 440.3.

Example 51: Preparation of 3-(2-methyl-5-(5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)pentyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02764)

Following the method of Scheme 6 and the method of example 47, under appropriate conditions understood in the field, the target compound GT-02764 was prepared (pale yellow solid, 10.0 mg, yield 36.16%). ¹H NMR (400 MHz, MeOD) δ 7.96 (t, J=7.9 Hz, 1H), 7.64 (dd, J=14.3, 7.9 Hz, 2H), 5.48 (dd, J=11.1, 5.7 Hz, 1H), 3.67 (dd, J=85.3, 32.7 Hz, 11H), 3.45-3.35 (m, 2H), 3.24-3.08 (m, 5H), 3.08-2.92 (m, 6H), 2.92-2.80 (m, 2H), 2.49 (d, J=13.0 Hz, 2H), 2.40 (dd, J=10.6, 5.2 Hz, 1H), 2.27-2.11 (m, 2H), 1.95-1.80 (m, 2H), 1.67 (s, 2H), 1.56 (dd, J=14.1, 6.9 Hz, 2H). LCMS (ESI) calcd for C₂₉H₄₃N₆O₃⁺ [M+H]⁺, 523.34; found, 523.3.

Example 52: Preparation of 3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02797)

The target compound 3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02797) was prepared by referring to the method of step 3 of Scheme 6.

8-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)octyl methanesulfonate (729119) (1 eq.) and adamantaneamine (2 eq.) were added into a 10 mL reaction flask, followed by the addition of NMP (1 mL), and then under nitrogen protection, sodium iodide (1.5 eq.) and DIPEA (3 eq.). After the addition was complete, the mixture was heated to 85° C. and stirred for 3 hours. After monitoring the reaction via LCMS and confirming its completion, the reaction mixture was subjected to preparative HPLC (0.05% HCl aq./acetonitrile) to give the target compound GT-02797 (pale yellow solid, 9.0 mg, yield 35.77%). ¹H NMR (400 MHz, MeOD) δ 7.77 (t, J=7.9 Hz, 1H), 7.48 (d, J=7.4 Hz, 1H), 7.41 (d, J=7.5 Hz, 1H), 5.29 (dd, J=11.0, 5.9 Hz, 1H), 3.19-3.03 (m, 2H), 2.93-2.60 (m, 8H), 2.27-2.17 (m, 1H), 2.11 (s, 3H), 1.82 (d, J=2.5 Hz, 6H), 1.67 (dd, J=32.3, 12.0 Hz, 6H), 1.50 (td, J=14.7, 7.3 Hz, 4H), 1.31 (s, 8H). LCMS (ESI) calcd for C₃₂H₄₅N₄O₃⁺ [M+H]⁺, 533.35; found, 533.3.

Example 53: Preparation of 3-(2-methyl-5-(8-(4-(oxetan-3-yl)piperazin-1-yl)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02798)

Following the method of Scheme 6 and the method of example 47, under appropriate conditions understood in the field, the target compound GT-02798 was prepared (pale yellow solid, 12.0 mg, yield 48.46%). ¹H NMR (400 MHz, MeOD) δ 7.82 (t, J=7.9 Hz, 1H), 7.49 (dd, J=15.9, 7.5 Hz, 2H), 5.34 (dd, J=10.9, 5.8 Hz, 1H), 4.67 (dt, J=13.0, 7.3 Hz, 4H), 4.28-3.22 (m, 9H), 3.19-2.99 (m, 4H), 2.96-2.53 (m, 6H), 2.26 (dt, J=11.1, 5.4 Hz, 1H), 1.69 (s, 2H), 1.54-1.41 (m, 2H), 1.31 (s, 8H). LCMS (ESI) calcd for C₂₉H₄₂N₅O₄⁺ [M+H]⁺, 524.32; found, 524.3.

Example 54: Preparation of 3-(2-methyl-5-(8-(4-methylpiperazin-1-yl)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02813)

Following the method of Scheme 6 and the method of example 47, under appropriate conditions understood in the field, the target compound GT-02813 was prepared (pale yellow solid, 14.0 mg, yield 61.12%). ¹H NMR (400 MHz, MeOD) δ 7.79 (t, J=7.9 Hz, 1H), 7.46 (dd, J=21.5, 7.4 Hz, 2H), 5.31 (dd, J=11.2, 5.7 Hz, 1H), 3.99-3.22 (m, 12H), 3.19-3.13 (m, 2H), 3.04 (dt, J=12.2, 7.7 Hz, 1H), 2.92 (s, 3H), 2.85-2.79 (m, 1H), 2.77-2.65 (m, 2H), 2.30-2.19 (m, 1H), 1.71 (s, 2H), 1.58-1.43 (m, 2H), 1.30 (d, J=15.0 Hz, 8H). LCMS (ESI) calcd for C₂₇H₄₀N₅O₃⁺ [M+H]⁺, 482.31; found, 482.3.

Example 55: Preparation of 3-(2-methyl-5-(8-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02799)

Following the method of Scheme 6 and the method of example 47, under appropriate conditions understood in the field, the target compound GT-02799 was prepared (pale yellow solid, 13.0 mg, yield 48.91%). ¹H NMR (400 MHz, MeOD) δ 7.94 (t, J=7.9 Hz, 1H), 7.70-7.54 (m, 2H), 5.48 (dd, J=11.2, 5.7 Hz, 1H), 3.97-3.37 (m, 12H), 3.32-3.24 (m, 2H), 3.23-3.07 (m, 5H), 3.05-2.92 (m, 5H), 2.92-2.77 (m, 2H), 2.50 (d, J=13.5 Hz, 2H), 2.44-2.35 (m, 1H), 2.29-2.10 (m, 2H), 1.79 (s, 2H), 1.59 (dt, J=27.3, 13.5 Hz, 2H), 1.41 (d, J=16.5 Hz, 8H). LCMS (ESI) calcd for C₃₂H₄₉N₆O₃⁺ [M+H]⁺, 565.39; found, 565.4.

Example 56: Preparation of 3-(5-(8-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02800)

Following the method of Scheme 6 and the method of example 47, under appropriate conditions understood in the field, the target compound GT-02800 was prepared (pale yellow solid, 13.0 mg, yield 56.78%). ¹H NMR (400 MHz, MeOD) δ 7.76 (td, J=8.0, 2.4 Hz, 1H), 7.48 (d, J=7.5 Hz, 1H), 7.40 (dd, J=7.4, 4.0 Hz, 1H), 5.29 (dd, J=11.3, 5.8 Hz, 1H), 4.67-4.15 (m, 2H), 3.90-3.53 (m, 2H), 3.48-3.33 (m, 2H), 3.32-3.22 (m, 2H), 3.20-2.97 (m, 4H), 2.92-2.56 (m, 5H), 2.24 (dd, J=10.2, 7.6 Hz, 2H), 1.83-1.63 (m, 2H), 1.49 (d, J=6.8 Hz, 2H), 1.32 (s, 8H). LCMS (ESI) calcd for C₂₇H₃₇N₄O₄⁺ [M+H]⁺, 481.28; found, 481.3.

Example 57: Preparation of 3-(5-(3-(((1s,3s)-adamantan-1-yl)amino)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02814)

Referring to the method of step 2 of Scheme 7, compound GT-02600 (1 eq.) was added to a 100 mL reaction flask, followed by the addition of Pd(PPh₃)Cl₂ (0.1 eq.) and copper iodide (1 eq.), and then under nitrogen protection, DMF (25 mL), TEA (3 mL) and (1s,3s)-N-(prop-2-yn-1-yl)adamantan-1-amine (GT-M-24) (3 eq.). After the addition was complete, the mixture was heated to 90° C. and stirred for 18 hours. After monitoring the reaction via LCMS and confirming its completion, the reaction mixture was filtered and subjected to preparative HPLC (0.05% HCl aq./acetonitrile) to give the target compound GT-02814 (pale yellow solid, 30.0 mg, yield 40.26%). ¹H NMR (400 MHz, DMSO) δ 10.93 (d, J=27.4 Hz, 1H), 9.30 (s, 2H), 7.76 (t, J=7.8 Hz, 1H), 7.61 (ddd, J=10.2, 5.4, 4.3 Hz, 2H), 5.23 (dd, J=11.5, 5.6 Hz, 1H), 4.13 (t, J=5.6 Hz, 2H), 2.84-2.77 (m, 1H), 2.63-2.55 (m, 5H), 2.15-2.09 (m, 1H), 2.06 (s, 3H), 1.83 (d, J=24.9 Hz, 6H), 1.62-1.51 (m, 6H). LCMS (ESI) calcd for C₂₇H₃₁N₄O₃⁺ [M+H]⁺, 459.24; found, 459.2.

Example 58: Preparation of 3-(5-((2-(2-(((1s,3s)-adamantan-1-yl)amino)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02234)

Referring to the method of step 3 of Scheme 8, (1s,3s)-N-(2-(2-aminoethoxy)ethyl)adamantan-1-amine (729023) (1 eq.) was added to a 10 mL reaction flask, followed by the addition of 2 mL DMSO, 3-(5-fluoro-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (1.1 eq.), and DIPEA (3 eq.). The mixture was then stirred at 130° C. for 10 h. After monitoring the reaction via LCMS and confirming its completion, the reaction mixture was subjected to preparative HPLC (0.05% HCl aq./acetonitrile) to give the target compound GT-02234 (pale yellow solid, 13.0 mg, yield 22.04%). ¹H NMR (400 MHz, MeOD) δ 7.78-7.68 (m, 1H), 6.93 (d, J=8.7 Hz, 1H), 6.80 (d, J=7.8 Hz, 1H), 5.41 (dd, J=11.1, 5.6 Hz, 1H), 3.82 (dt, J=12.9, 5.1 Hz, 4H), 3.58 (t, J=5.2 Hz, 2H), 3.26-3.21 (m, 2H), 3.01-2.85 (m, 4H), 2.81 (td, J=16.5, 8.1 Hz, 2H), 2.41-2.31 (m, 1H), 2.23 (s, 3H), 1.95 (d, J=2.4 Hz, 6H), 1.82-1.74 (m, 6H). LCMS (ESI) calcd for C₂₈H₃₈N₅O₄⁺ [M+H]⁺, 508.29; found, 509.0.

Example 59: Preparation of 3-(5-((2-(2-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02389)

Following the method of Scheme 8 and the method of example 58, under appropriate conditions understood in the field, the target compound GT-02389 was prepared (pale yellow solid, 10.0 mg, yield 16.92%). ¹H NMR (400 MHz, MeOD) δ 7.76-7.64 (m, 1H), 6.88 (d, J=8.6 Hz, 1H), 6.79 (d, J=7.5 Hz, 1H), 5.38 (dd, J=11.4, 5.8 Hz, 1H), 3.84 (dt, J=10.4, 5.3 Hz, 4H), 3.57 (t, J=5.2 Hz, 2H), 3.30-3.20 (m, 2H), 3.05-2.70 (m, 6H), 2.43 (d, J=5.2 Hz, 3H), 2.37-2.28 (m, 1H), 2.01 (q, J=10.3 Hz, 6H), 1.73 (d, J=8.8 Hz, 3H), 1.63 (d, J=13.1 Hz, 1H). LCMS (ESI) calcd for C₂₇H₃₆N₅O₄⁺ [M+H]⁺, 494.28; found, 494.7.

Example 60: Preparation of 3-(2-methyl-5-((2-(2-(4-methyl-1,4-diazepan-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02493)

Following the method of Scheme 8 and the method of example 58, under appropriate conditions understood in the field, the target compound GT-02493 was prepared (pale yellow solid, 20.0 mg, yield 31.24%). ¹H NMR (400 MHz, MeOD) δ 7.78-7.67 (m, 1H), 6.94 (d, J=8.7 Hz, 1H), 6.82 (d, J=7.7 Hz, 1H), 5.43 (dd, J=11.3, 5.5 Hz, 1H), 3.89 (ddd, J=18.8, 9.4, 4.4 Hz, 10H), 3.65-3.50 (m, 6H), 3.03-2.78 (m, 9H), 2.38 (dd, J=9.2, 6.3 Hz, 3H). LCMS (ESI) calcd for C₂₄H₃₅N₆O₄⁺ [M+H]⁺, 471.27; found, 471.6.

Example 61: preparation of (3r,5r,7r)-N-(5-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)pentyl)adamantane-1-carboxamide (GT-02323)

Following the method of Scheme 8 and the method of example 58, under appropriate conditions understood in the field, the target compound GT-02323 was prepared (pale yellow solid, 26.0 mg, yield 35.03%). ¹H NMR (400 MHz, MeOD) δ 7.61-7.49 (m, 1H), 6.68 (d, J=8.6 Hz, 1H), 6.61 (d, J=7.7 Hz, 1H), 5.21 (dd, J=10.9, 5.6 Hz, 1H), 3.19 (t, J=7.1 Hz, 2H), 3.12-3.05 (m, 2H), 2.89-2.53 (m, 6H), 2.18 (dd, J=8.7, 4.2 Hz, 1H), 1.91 (s, 3H), 1.74 (d, J=2.6 Hz, 6H), 1.64 (dd, J=14.4, 10.5 Hz, 8H), 1.45 (dd, J=14.4, 7.3 Hz, 2H), 1.38-1.27 (m, 2H). LCMS (ESI) calcd for C₃₀H₄₀N₅O₄⁺ [M+H]⁺, 534.3; found, 535.0.

Example 62: Preparation of 3-(5-((2-(2-(2-(((1s,3s)-adamantan-1-yl)amino)ethoxy)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02279)

Following the method of Scheme 8 and the method of example 58, under appropriate conditions understood in the field, the target compound GT-02279 was prepared (pale yellow solid, 10.0 mg, yield 5.94%). LCMS (ESI) calcd for C₃₀H₄₂N₅O₅⁺ [M+H]⁺, 552.32; found, 552.3. ¹H NMR (500 MHz, DMSO) δ 11.02 (s, 1H), 8.45 (s, 3H), 7.53 (t, J=8.1 Hz, 1H), 6.70 (d, J=7.8 Hz, 1H), 6.59 (d, J=8.4 Hz, 1H), 5.22 (dd, J=11.6, 5.6 Hz, 1H), 3.66 (t, J=5.1 Hz, 5H), 3.61 (s, 5H), 3.02-2.96 (m, 2H), 2.89-2.80 (m, 1H), 2.61 (s, 3H), 2.19-2.15 (m, 1H), 2.11-2.08 (m, 3H), 1.83-1.80 (m, 6H), 1.66-1.53 (m, 8H).

Example 63: Preparation of 3-(5-((5-(((3s,5s,7s)-adamantan-1-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02280)

Following the method of Scheme 8 and the method of example 58, under appropriate conditions understood in the field, the target compound GT-02280 was prepared (pale yellow solid, 2.5 mg, yield 2.13%). LC/MS (ESI) calcd for C₂₉H₄₀N₅O₃⁺ [M+H]⁺, 506.31; found, 506.3.

Example 64: Preparation of 3-(5-((4-(((1r,3r,5r,7r)-adamantan-2-yl)amino)butyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02392)

Following the method of Scheme 8 and the method of example 58, under appropriate conditions understood in the field, the target compound GT-02392 was prepared (pale yellow solid, 10 mg, yield 5.81%). LCMS (ESI) calcd for C₂₈H₃₈N₅O₃⁺ [M+H]⁺, 492.30; found, 492.6. ¹H NMR (500 MHz, DMSO) δ 11.01 (s, 1H), 8.37 (s, 2H), 7.53 (t, J=8.1 Hz, 1H), 6.69 (d, J=7.9 Hz, 1H), 6.58 (d, J=8.4 Hz, 1H), 5.22 (dd, J=11.4, 5.6 Hz, 1H), 2.99-2.96 (m, 2H), 2.90-2.82 (m, 2H), 2.77 (d, J=4.8 Hz, 1H), 2.60 (s, 3H), 2.16-2.10 (m, 4H), 1.75-1.68 (m, 10H), 1.59-1.50 (m, 4H).

Example 65: Preparation of 3-(5-((5-(((1r,3r,5r,7r)-adamantan-2-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02393)

Following the method of Scheme 8 and the method of example 58, under appropriate conditions understood in the field, the target compound GT-02393 was prepared (pale yellow solid, 10 mg, yield 9.28%). LCMS (ESI) calcd for C₂₉H₄₀N₅O₃⁺ [M+H]⁺, 506.31; found, 506.8. ¹H NMR (400 MHz, MeOD) δ 7.69-7.59 (m, 1H), 6.81-6.70 (m, 2H), 5.30 (dd, J=11.2, 5.9 Hz, 1H), 3.36 (d, J=21.6 Hz, 2H), 3.10-2.99 (m, 2H), 2.92-2.85 (m, 1H), 2.80 (s, 3H), 2.78-2.71 (m, 1H), 2.32-2.25 (m, 1H), 2.22-2.14 (m, 2H), 2.02-1.91 (m, 6H), 1.90-1.71 (m, 12H), 1.61-1.50 (m, 2H).

Example 66: Preparation of 3-(5-((5-(((2R,3as,5S,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02496)

Following the method of Scheme 8 and the method of example 58, under appropriate conditions understood in the field, the target compound GT-02496 was prepared (pale yellow solid, 10 mg, yield 6.74%). LCMS (ESI) calcd for C₂₈H₃₈N₅O₃⁺ [M+H]⁺, 492.30; found, 492.8. ¹H NMR (400 MHz, MeOD) δ 7.73-7.65 (m, 1H), 6.84 (d, J=8.6 Hz, 1H), 6.74 (d, J=7.4 Hz, 1H), 5.36 (dd, J=11.0, 5.9 Hz, 1H), 3.39-3.33 (m, 2H), 3.05-2.98 (m, 2H), 2.88 (s, 3H), 2.85-2.73 (m, 2H), 2.48-2.38 (m, 3H), 2.37-2.27 (m, 1H), 2.07-1.92 (m, 6H), 1.84-1.68 (m, 7H), 1.64-1.53 (m, 3H).

Example 67: Preparation of 3-(5-((2-(2-(2-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethoxy)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02497)

Following the method of Scheme 8 and the method of example 58, under appropriate conditions understood in the field, the target compound GT-02497 was prepared (pale yellow solid, 10 mg, yield 8.79%). LCMS (ESI) calcd for C₂₉H₄₀N₅O₅⁺ [M+H]⁺, 538.30; found, 538.8. ¹H NMR (400 MHz, MeOD) δ 7.75-7.68 (m, 1H), 6.89 (d, J=8.6 Hz, 1H), 6.77 (d, J=7.6 Hz, 1H), 5.39 (dd, J=11.3, 5.7 Hz, 1H), 3.82-3.74 (m, 6H), 3.56-3.46 (m, 4H), 3.22-3.18 (m, 2H), 2.92 (s, 3H), 2.85-2.74 (m, 2H), 2.38-2.31 (m, 2H), 2.08-1.91 (m, 10H), 1.67-1.54 (m, 2H).

Example 68: Preparation of 3-(2-methyl-5-((5-(4-methyl-1,4-diazepan-1-yl)pentyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02500)

Following the method of Scheme 8 and the method of example 58, under appropriate conditions understood in the field, the target compound GT-02500 was prepared (pale yellow solid, 10 mg, yield 6.58%). LC/MS (ESI) calcd for C₂₅H₃₇N₆O₃⁺ [M+H]⁺, 469.29; found, 469.3.

Example 69: Preparation of 3-(5-((3-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03697)

Following the method of Scheme 9 and the method of example 1, under appropriate conditions understood in the field, the target compound GT-03697 was prepared (19 mg, yield: 36%, white solid). ¹H NMR (400 MHz, DMSO) δ 11.03 (s, 1H), 7.70 (t, J=8.0 Hz, 1H), 7.57-7.48 (m, 4H), 7.46-7.39 (m, 6H), 7.34 (d, J=8.0 Hz, 1H), 7.29 (d, J=8.0 Hz, 1H), 5.27-5.22 (m, 1H), 3.54-3.38 (m, 3H), 3.30-3.22 (m, 3H), 3.18-3.08 (m, 2H), 3.06-2.96 (m, 3H), 2.91-2.82 (m, 3H), 2.63 (s, 3H), 2.26-2.13 (m, 2H), 2.10-2.06 (m, 3H). LC/MS (ESI) calcd for C₃₄H₃₆C₁₂N₅O₃S⁺ [M+H]⁺, 664.19; found, 664.2.

Example 70: Preparation of 3-(5-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-04231)

The target compound GT-04231 was prepared by referring to the method of Scheme 11.

Step 1: to a solution of 3-(5-fluoro-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (1.0 eq.) and tert-butyl 3,6-diazabicyclo[3.1.1]hept-3-carboxylate (1.5 eq.) in dimethyl sulfoxide was added triethylamine (3.0 eq.). The reaction solution was heated to 120° C. and stirred for 18 hours. After monitoring the reaction via TLC and confirming its completion, the reaction mixture was cooled to room temperature, washed with water, and extracted with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by silica gel column chromatography to give tert-butyl 6-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)-3,6-diazabicyclo[3.1.1]hept-3-carboxylate.

Step 2: to a solution of the product obtained from the previous step in dichloromethane was added trifluoroacetic acid. The reaction solution was stirred at room temperature for 2 hours. After monitoring the reaction via LCMS and confirming its completion, the reaction solution was concentrated under reduced pressure to give 3-(5-(3,6-diazabicyclo[3.1.1]hept-6-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione hydrochloride.

Step 3: to a solution of 3-(5-(3,6-diazabicyclo[3.1.1]hept-6-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione hydrochloride (1.0 eq.) obtained from Step 2 and (3r,5r,7r)-1-(2-bromoethyl)adamantane (1.3 eq.) in anhydrous DMF (3 mL) were added triethylamine (3.0 eq.) and sodium iodide (1.0 eq.). The reaction solution was stirred at 50° C. for 18 hours. After monitoring the reaction via LCMS and confirming its completion, the reaction solution was filtered, and the filtrate was subjected to HPLC for purification to give the target compound GT-04231 (8 mg, yield: 17%, white solid). LC/MS (ESI) calcd for C₃₁H₄₀N₅O₃ [M+H]⁺, 530.31; found, 530.3.

Example 71: Preparation of 3-(5-(6-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-04230)

Following the method of Scheme 11 and the method of example 70, under appropriate conditions understood in the field, the target compound GT-04230 was prepared (16 mg, yield: 26%, white solid). LC/MS (ESI) calcd for C₃₁H₄₀N₅O₃ [M+H]⁺, 530.31; found, 530.3.

Example 72: Preparation of 3-(5-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-04253)

Following the method of Scheme 11 and the method of example 70, under appropriate conditions understood in the field, the target compound GT-04253 was prepared (17 mg, yield: 29%, white solid). ¹H NMR (400 MHz, DMSO) δ 6.98 (t, J=8.2 Hz, 1H), 6.46 (d, J=8.2 Hz, 1H), 6.40 (d, J=8.2 Hz, 1H), 4.56-4.52 (m, 1H), 3.50 (d, J=6.0 Hz, 1H), 3.25 (brs, 1H), 2.91-2.77 (m, 2H), 2.77-2.65 (m, 2H), 2.47-2.43 (m, 2H), 2.16-1.91 (m, 5H), 1.57-1.53 (m, 1H), 1.44-1.38 (m, 1H), 1.35-1.12 (m, 6H), 0.96 (dd, J=31.2, 12.0 Hz, 6H), 0.81 (s, 9H). LC/MS (ESI) calcd for C₃₂H₄₂N₅O₃⁺ [M+H]⁺, 544.33; found, 544.4.

Example 73: Preparation of 3-(5-(8-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03727)

Following the method of Scheme 11 and the method of example 70, under appropriate conditions understood in the field, the target compound GT-03727 was prepared (18 mg, yield: 31%, white solid). LC/MS (ESI) calcd for C₃₂H₄₂N₅O₃⁺ [M+H]⁺, 544.33; found, 544.4.

Example 74: Preparation of 3-(5-(5-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-04228)

Following the method of Scheme 11 and the method of example 70, under appropriate conditions understood in the field, the target compound GT-04228 was prepared (20 mg, yield: 34%, white solid). LC/MS (ESI) calcd for C₃₂H₄₂N₅O₃⁺ [M+H]⁺, 544.33; found, 544.4.

Example 75: Preparation of 3-(5-((1S,4S)-5-(2-((3S,5S,7S)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-04232)

Following the method of Scheme 11 and the method of example 70, under appropriate conditions understood in the field, the target compound GT-04232 was prepared (12 mg, yield: 20%, white solid). LC/MS (ESI) calcd for C₃₁H₄₀N₅O₃⁺ [M+H]⁺, 530.31; found, 530.3.

Example 76: Preparation of 3-(5-((1R,4R)-5-(2-((3R,5R,7R)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-04233)

Following the method of Scheme 11, under appropriate conditions understood in the field, the target compound GT-04233 was prepared (14 mg, yield: 23%, white solid). LC/MS (ESI) calcd for C₃₁H₄₀N₅O₃ [M+H]⁺, 530.31; found, 530.3.

Example 77: Preparation of 3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,5-dimethylpiperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-04246)

Following the method of Scheme 11, under appropriate conditions understood in the field, the target compound GT-04246 was prepared (5 mg, yield: 10%, white solid). LC/MS (ESI) calcd for C₃₂H₄₄N₅O₃⁺ [M+H]⁺, 546.34; found, 546.3.

Example 78: Preparation of 3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-1,4-diazepan-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-04229)

Following the method of Scheme 11, under appropriate conditions understood in the field, the target compound GT-04229 was prepared (10 mg, yield: 15%, white solid). LC/MS (ESI) calcd for C₃₁H₄₂N₅O₃⁺ [M+H]⁺, 532.33; found, 532.3.

Example 79: Preparation of 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03305)

Following the method of Scheme 9 and the method of example 1, under appropriate conditions understood in the field, the target compound GT-03305 was prepared (8 mg, yield: 20%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.70 (t, J=8.0 Hz, 1H), 7.38-7.32 (m, 2H), 5.30-5.22 (m, 1H), 3.52-3.49 (m, 1H), 3.46-3.39 (m, 3H), 3.24-3.16 (m, 5H), 2.96-2.86 (m, 3H), 2.86-2.80 (m, 1H), 2.80-2.76 (m, 1H), 2.75-2.69 (m, 1H), 2.69 (s, 3H), 2.28-2.20 (m, 1H), 2.05-1.97 (m, 3H), 1.85-1.77 (m, 3H), 1.76-1.68 (m, 3H), 1.65-1.57 (m, 6H), 1.54-1.47 (m, 2H). LC/MS (ESI) calcd for C₃₂H₄₄N₅O₃S⁺ [M+H]⁺, 578.31; found, 578.3.

Example 80: Preparation of 4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)thio)ethyl)piperazin-1-yl)-3-fluorobenzonitrile (GT-03314)

Following the method of Scheme 9 and the method of example 1, under appropriate conditions understood in the field, the target compound GT-03314 was prepared (12 mg, yield: 45%, white solid). LC/MS (ESI) calcd for C₂₇H₂₈FN₆O₃S⁺ [M+H]⁺, 535.19; found, 535.2.

Example 81: Preparation of 3-(5-((2-(4-(4-((1s,3s)-adamantan-1-yl)benzyl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03315)

Following the method of Scheme 9 and the method of example 1, under appropriate conditions understood in the field, the target compound GT-03315 was prepared (8 mg, yield: 23%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.71 (t, J=8.0 Hz, 1H), 7.42-7.36 (m, 5H), 7.30 (d, J=8.0 Hz, 1H), 5.26-5.21 (m, 1H), 4.24 (brs, 2H), 3.45-3.32 (m, 4H), 3.13-3.08 (m, 2H), 2.87-2.73 (m, 2H), 2.72 (s, 3H), 2.76-2.61 (m, 2H), 2.28-2.12 (m, 1H), 2.00 (brs, 4H), 1.85 (brs, 7H), 1.77-1.69 (m, 9H). LC/MS (ESI) calcd for C₃₇H₄₆N₅O₃S⁺ [M+H]⁺, 640.33; found, 640.3.

Example 82: Preparation of 3-(5-((2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03284)

Following the method of Scheme 10 and the method of example 4, under appropriate conditions understood in the field, the target compound GT-03284 was prepared (8 mg, yield: 27%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.66 (t, J=8.4 Hz, 1H), 6.88 (d, J=8.4 Hz, 1H), 6.74 (d, J=8.4 Hz, 1H), 5.31-5.26 (m, 1H), 3.78-3.61 (m, 6H), 3.49-3.36 (m, 2H), 2.82 (s, 3H), 2.79-2.59 (m, 3H), 2.25-2.20 (m, 4H), 1.98 (brs, 7H), 1.73-1.64 (m, 7H), 1.29-1.27 (m, 1H), 1.24-1.20 (m, 1H). LC/MS (ESI) calcd for C₃₀H₄₁N₆O₃⁺ [M+H]⁺, 533.32; found, 533.3.

Example 82: Preparation of 3-(5-((2-(4-(((1s,3s)-adamantan-1-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03285)

Following the method of Scheme 10 and the method of example 4, under appropriate conditions understood in the field, the target compound GT-03285 was prepared (9 mg, yield: 32%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.79 (t, J=8.2 Hz, 1H), 7.01 (d, J=8.2 Hz, 1H), 6.86 (d, J=8.2 Hz, 1H), 5.43-5.39 (m, 1H), 3.82-3.76 (m, 3H), 3.69-3.56 (m, 6H), 3.02-2.98 (m, 2H), 2.95 (s, 3H), 2.91-2.76 (m, 3H), 2.38-2.34 (m, 1H), 2.07 (s, 3H), 1.79 (s, 15H). LC/MS (ESI) calcd for C₃₁H₄₃N₆O₃⁺ [M+H]⁺, 547.37; found, 547.3.

Example 82: Preparation of 3-(5-((2-(4-(4-((1s,3s)-adamantan-1-yl)benzyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03316)

Following the method of Scheme 10 and the method of example 4, under appropriate conditions understood in the field, the target compound GT-03316 was prepared (5 mg, yield: 15%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.63 (t, J=8.4 Hz, 1H), 7.46-7.34 (m, 4H), 6.81 (d, J=8.4 Hz, 1H), 6.69 (d, J=8.4 Hz, 1H), 5.31-5.27 (m, 1H), 4.26-4.23 (m, 2H), 3.53-3.47 (m, 3H), 3.43-3.29 (m, 4H), 2.73-2.68 (m, 3H), 2.31-2.19 (m, 1H), 2.00 (brs, 3H), 1.85 (brs, 7H), 1.77-1.69 (m, 8H). LC/MS (ESI) calcd for C₃₇H₄₇N₆O₃⁺ [M+H]⁺, 623.37; found, 623.3.

Example 83: Preparation of 4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)ethyl)piperazin-1-yl)-3-fluorobenzonitrile (GT-03313)

Following the method of Scheme 10 and the method of example 4, under appropriate conditions understood in the field, the target compound GT-03313 was prepared (14 mg, yield: 52%, white solid). H NMR (400 MHz, MeOD) δ 7.66 (t, J=8.4 Hz, 1H), 7.44-7.41 (m, 2H), 7.11 (t, J=8.4 Hz, 1H), 6.88 (d, J=8.4 Hz, 1H), 6.78 (d, J=8.4 Hz, 1H), 5.28-5.24 (m, 1H), 3.79 (t, J=6. 4 Hz, 2H), 3.68 (brs, 4H), 3.43 (t, J=6.4 Hz, 3H), 3.38-3.23 (m, 4H), 2.88-2.79 (m, 1H), 2.77 (s, 3H), 2.75-2.62 (m, 2H), 2.24-2.20 (m, 1H). LC/MS (ESI) calcd for C₂₇H₂₉FN₇O₃⁺ [M+H]⁺, 518.23; found, 518.3.

Example 84: Preparation of 3-(5-(2-(4-((3s,5s,7s)-adamantan-1-yl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03310)

Following the method of Scheme 10 and the method of example 4, under appropriate conditions understood in the field, the target compound GT-03310 was prepared (6 mg, yield: 20%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.85 (t, J=8.0 Hz, 1H), 7.36 (d, J=8.0 Hz, 1H), 7.22 (d, J=8.0 Hz, 1H), 5.36-5.29 (m, 1H), 4.53-4.50 (m, 2H), 4.13-4.04 (m, 2H), 3.97-3.87 (m, 2H), 3.71-3.62 (m, 2H), 3.52-3.48 (m, 2H), 3.17-3.14 (m, 1H), 2.76 (s, 3H), 2.76-2.71 (m, 1H), 2.38-2.29 (m, 5H), 2.08 (s, 6H), 1.82 (s, 9H). LC/MS (ESI) calcd for C₃₀H₃₉N₅O₄⁺ [M+H]⁺, 534.31; found, 534.3.

Example 85: Preparation of 3-(5-(2-(4-(4-((1s,3s)-adamantan-1-yl)benzyl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03311)

Following the method of Scheme 10 and the method of example 4, under appropriate conditions understood in the field, the target compound GT-03311 was prepared (8 mg, yield: 23%, white solid). LC/MS (ESI) calcd for C₃₇H₄₆N₅O₄⁺ [M+H]⁺, 624.35; found, 624.4.

Example 86: Preparation of 4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)oxy)ethyl)piperazin-1-yl)-3-fluorobenzonitrile (GT-03312)

Following the method of Scheme 10 and the method of example 4, under appropriate conditions understood in the field, the target compound GT-03312 was prepared (12 mg, yield: 47%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.87 (t, J=8.0 Hz, 1H), 7.58-7.54 (m, 2H), 7.40 (d, J=8.0 Hz, 1H), 7.27-7.21 (m, 2H), 5.37-5.34 (m, 1H), 4.64-4.61 (m, 2H), 4.01-3.97 (m, 1H), 3.84-3.77 (m, 6H), 3.62-3.48 (m, 3H), 2.97-2.92 (m, 2H), 2.78 (s, 3H), 2.75-2.70 (m, 1H), 2.33-2.27 (m, 1H). LC/MS (ESI) calcd for C₂₇H₂₈FN₆O₄⁺ [M+H]⁺, 519.22; found, 519.3.

Example 87: Preparation of 3-(5-((4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03261)

Following the method of Scheme 12, under appropriate conditions understood in the field, the target compound GT-03261 was prepared (6 mg, yield: 24%, white solid). LC/MS (ESI) calcd for C₃₁H₄₂N₅O₃⁺ [M+H]⁺, 532.33; found, 532.3.

Example 88: Preparation of 3-(5-((4-((1s,3s)-adamantane-1-carbonyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03317)

Following the method of Scheme 12, under appropriate conditions understood in the field, the target compound GT-03317 was prepared (7 mg, yield: 20%, white solid). LC/MS (ESI) calcd for C₃₀H₃₈N₅O₄⁺ [M+H]⁺, 532.29; found, 532.3.

Example 89: Preparation of 3-(5-(3-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03302)

Following the method of steps 1-3 of Scheme 5 and the method of step 3 of Scheme 10, under appropriate conditions understood in the field, the target compound GT-03302 was prepared (8 mg, yield: 26%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.79 (t, J=8.0 Hz, 1H), 7.67 (d, J=8.0 Hz, 1H), 7.63 (d, J=8.0 Hz, 1H), 5.30-5.25 (m, 1H), 4.25 (s, 2H), 3.79 (brs, 4H), 3.64-3.42 (m, 4H), 2.98-2.90 (m, 2H), 2.86-2.81 (m, 1H), 2.74 (s, 3H), 2.68-2.65 (m, 1H), 2.64-2.61 (m, 1H), 2.28-2.14 (m, 1H), 1.97 (s, 3H), 1.70 (s, 12H). LC/MS (ESI) calcd for C₃₂H₄₀N₅O₃⁺ [M+H]⁺, 542.31; found, 542.3.

Example 90: Preparation of 3-(5-(3-(4-(2-((1s,3s)-adamantan-1-yl)ethyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03262)

Following the method of example 89, under appropriate conditions understood in the field, the target compound GT-03262 was prepared (12 mg, yield: 19%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.88 (t, J=8.0 Hz, 1H), 7.73 (t, J=8.0 Hz, 2H), 5.40-5.34 (m, 1H), 4.18 (s, 2H), 3.99-3.72 (m, 4H), 3.49-3.40 (m, 3H), 2.99-2.94 (m, 2H), 2.83 (s, 3H), 2.82-2.77 (m, 2H), 2.40-2.28 (m, 1H), 2.01 (brs, 4H), 1.82-1.72 (m, 6H), 1.65 (s, 9H). LC/MS (ESI) calcd for C₃₃H₄₂N₅O₃⁺ [M+H]⁺, 556.33; found, 556.3.

Example 91: Preparation of 3-(5-(3-(4-((3r,5r,7r)-adamantane-1-carbonyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03318)

Following the method of example 89, under appropriate conditions understood in the field, the target compound GT-03318 was prepared (8 mg, yield: 26%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.75 (t, J=8.0 Hz, 1H), 7.63-7.60 (m, 2H), 5.25-5.16 (m, 1H), 4.39-4.26 (m, 2H), 4.02-3.82 (m, 1H), 3.81-3.58 (m, 1H), 2.86-2.75 (m, 1H), 2.66 (s, 3H), 2.66-2.62 (m, 1H), 2.26-2.18 (m, 1H), 1.99-1.91 (m, 7H), 1.70 (s, 6H), 1.20 (s, 9H). LC/MS (ESI) calcd for C₃₂H₃₈N₅O₄⁺ [M+H]⁺, 556.29; found, 556.3.

Example 92: Preparation of 3-(5-((2-(4-benzhydrylpiperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03385)

Following the method of Scheme 10 and the method of Example 4, under appropriate conditions understood in the field, the target compound GT-03385 was prepared (12 mg, yield: 25%, white solid). LC/MS (ESI) calcd for C₃₄H₃₈N₅O₃⁺ [M+H]⁺, 564.30; found, 564.3.

Example 93: Preparation of 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-02802)

Following the method of Scheme 9, under appropriate conditions understood in the field, the target compound GT-02802 was prepared (1.6 mg, yield: 20%, white solid). LC/MS (ESI) calcd for C₃₁H₄₃N₄O₃S⁺ [M+H]⁺, 551.31; found, 551.3.

Example 94: Preparation of 3-(2-methyl-4-oxo-5-(piperazin-1-ylmethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03228)

Following the method of steps 1-2 of Scheme 12, under appropriate conditions understood in the field, the target compound GT-03228 was prepared (540 mg, yield: 91%, white solid). LC/MS (ESI) calcd for C₁₉H₂₄N₅O₃⁺[M+H]⁺, 370.19; found, 370.2.

Example 95: Preparation of 3-(5-((4-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03226)

Following the method of Scheme 12, under appropriate conditions understood in the field, the target compound GT-03226 was prepared (8 mg, yield: 24%, white solid). LC/MS (ESI) calcd for C₃₂H₄₅N₆O₃⁺[M+H]⁺, 561.35; found, 561.4.

Example 96: Preparation of 3-(5-((4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03227)

Following the method of Scheme 12, under appropriate conditions understood in the field, the target compound GT-03227 was prepared (1 mg, yield: 3%, white solid). LC/MS (ESI) calcd for C₃₀H₄₀N₅O₃⁺ [M+H]⁺, 518.31; found, 518.3.

Example 97: Preparation of 3-(5-((4-(4-((3r,5r,7r)-adamantan-1-yl)benzyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03230)

Following the method of Scheme 12, under appropriate conditions understood in the field, the target compound GT-03230 was prepared (4 mg, yield: 15%, white solid). ¹H NMR (400 MHz, CD3OD) δ 7.96-7.90 (m, 1H), 7.83 (d, J=8.0 Hz, 1H), 7.70 (d, J=8.0 Hz, 1H), 7.52-7.49 (m, 5H), 5.45-5.33 (m, 1H), 4.46-4.31 (m, 2H), 3.80-3.56 (m, 7H), 2.97-2.87 (m, 2H), 2.83 (s, 3H), 2.31-2.27 (m, 1H), 2.09 (brs, 4H), 1.96-1.91 (m, 6H), 1.86-1.77 (m, 9H). LC/MS (ESI) calcd for C₃₆H₄₄N₅O₃⁺ [M+H]⁺, 594.34; found, 594.3.

Example 98: Preparation of 3-(5-((4-(7-(((1s,3s)-adamantan-1-yl)amino)heptyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03258)

Following the method of Scheme 12, under appropriate conditions understood in the field, the target compound GT-03258 was prepared (4 mg, yield: 22%, white solid). LC/MS (ESI) calcd for C₃₅H₅₁N₆O₃⁺ [M+H]⁺, 603.4; found, 603.4.

Example 99: Preparation of 3-(5-((2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03231)

Following the method of Scheme 9 and the method of Example 1, under appropriate conditions understood in the field, the target compound GT-03231 was prepared (6 mg, yield: 21%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.87 (t, J=8.0 Hz, 1H), 7.61 (d, J=8.0 Hz, 1H), 7.46 (d, J=8.0 Hz, 1H), 5.39-5.35 (m, 1H), 3.91-3.83 (m, 4H), 3.56-3.42 (m, 6H), 2.86 (s, 3H), 2.99-2.75 (m, 2H), 2.31 (brs, 4H), 2.10 (brs, 7H), 1.85-1.76 (m, 8H). LC/MS (ESI) calcd for C₃H₄₀N₅₀O₃S⁺ [M+H]⁺, 550.28; found, 550.3.

Example 100: Preparation of 3-(5-((3-(4-((3s,5s,7s)-adamantan-1-yl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03232)

Following the method of Scheme 9 and the method of Example 1, under appropriate conditions understood in the field, the target compound GT-03232 was prepared (8 mg, yield: 28%, white solid). 1H NMR (400 MHz, CD₃OD_SPE) δ 7.83 (t, J=8.0 Hz, 1H), 7.49 (d, J=8.0 Hz, 1H), 7.43 (d, J=8.0 Hz, 1H), 5.35-5.30 (m, 1H), 4.00-3.85 (m, 4H), 3.61-3.43 (m, 6H), 3.20-3.11 (m, 2H), 2.93-2.89 (m, 1H), 2.81 (s, 3H), 2.85-2.67 (m, 2H), 2.30-2.26 (m, 3H), 2.07 (s, 7H), 1.83-1.74 (m, 8H). LC/MS (ESI) calcd for C₃₁H₄₂N₅O₃S⁺ [M+H]⁺, 564.30; found, 564.3.

Example 101: Preparation of 3-(5-((3-(4-(((1s,3s)-adamantan-1-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03235)

Following the method of Scheme 9 and the method of Example 1, under appropriate conditions understood in the field, the target compound GT-03235 was prepared (8 mg, yield: 28%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.90 (t, J=8.0 Hz, 1H), 7.58 (d, J=8.0 Hz, 1H), 7.48 (d, J=8.0 Hz, 1H), 5.42-5.38 (m, 1H), 3.89-3.73 (m, 6H), 3.54-3.45 (m, 2H), 3.29-3.14 (m, 3H), 3.12-3.02 (m, 2H), 2.96-2.94 (m, 1H), 2.90 (s, 3H), 2.82-2.76 (m, 2H), 2.66-2.65 (m, 2H), 2.38-2.24 (m, 3H), 2.09 (s, 3H), 1.80 (s, 12H), 1.42-1.39 (m, 2H). LC/MS (ESI) calcd for C₃₂H₄₄N₅O₃S⁺ [M+H]⁺, 578.32; found, 578.3.

Example 102: Preparation of 3-(5-((2-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03259)

Following the method of Scheme 9 and the method of Example 1, under appropriate conditions understood in the field, the target compound GT-03259 was prepared (8 mg, yield: 27%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.79 (t, J=8.0 Hz, 1H), 7.54 (d, J=8.0 Hz, 1H), 7.36 (d, J=8.0 Hz, 1H), 5.31-5.26 (m, 1H), 4.05-3.95 (m, 1H), 3.67-3.55 (m, 5H), 3.38 (s, 3H), 2.97-2.83 (m, 4H), 2.85-2.69 (m, 7H), 2.22-2.17 (m, 1H), 1.95 (s, 6H), 1.67 (s, 9H). LC/MS (ESI) calcd for C₃₁H₄₂N₅O₃S⁺ [M+H]⁺, 564.30; found, 564.3.

Example 103: Preparation of 3-(2-methyl-4-oxo-5-(3-(piperazin-1-yl)prop-1-yn-1-yl)quinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03229)

Following the method of Scheme 5 and the method of Example 33, under appropriate conditions understood in the field, the target compound GT-03229 was prepared (320 mg, yield: 112%, white solid). LC/MS (ESI) calcd for C₂₁H₂₄N₅O₃⁺ [M+H]⁺, 394.19; found, 394.2.

Example 104: Preparation of 3-(5-(3-(4-(4-((3r,5r,7r)-adamantan-1-yl)benzyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione (GT-03233)

Following the method of Scheme 5 and the method of Example 33, under appropriate conditions understood in the field, the target compound GT-03233 was prepared (20 mg, yield: 42%, white solid). ¹H NMR (400 MHz, MeOD) δ 7.81 (t, J=8.0 Hz, 1H), 7.70 (d, J=8.0 Hz, 1H), 7.64 (d, J=8.0 Hz, 1H), 7.49-7.40 (m, 4H), 5.31-5.27 (m, 1H), 4.33 (q, J=13.2 Hz, 2H), 4.23 (s, 2H), 3.64-3.41 (m, 6H), 2.92-2.64 (m, 6H), 2.26-2.18 (m, 1H), 2.01 (s, 3H), 1.86 (s, 7H), 1.77-1.69 (m, 8H). LC/MS (ESI) calcd for C₃₈H₄₄N₅O₃⁺ [M+H]⁺, 618.34; found, 618.3.

Biological Activity Assay

Materials:

Reagents and materials           Suppliers or Source
Human Burkitt's lymphoma cell line: Daudi Dalian Meilun Biotech Co., Ltd.
Human acute lymphoblastic leukemia cell line: Kasumi-1 ATCC (American Type Culture Collection)
Human colon cancer cell: SW620   ATCC
Human multiple myeloma cells: MM.1S ATCC
Human B-lymphoma cell: Ramos     Dalian Meilun Biotech Co., Ltd.
Human dexamethasone-resistant multiple myeloma ATCC
cell line: MM.1R
Human diffuse large B-cell lymphoma cell line: TMD8 Kyinno Biotechnology Co., Ltd
RPMI-1640 Medium                 Dalian Meilun Biotech Co., Ltd.
L-15 Medium                      ATCC
Meilun Cell Counting Kit-8       Dalian Meilun Biotech Co., Ltd.
Fetal bovine serum (FBS)         Sunrise Science Products company
Penicillin-Streptomycin          Beijing TransGen Biotech Co., Ltd.
Mycoplasma detection kit         Beijing TransGen Biotech Co., Ltd.
STR genotype detection           Shanghai Biowing Applied Biotechnology Co. Ltd.

Antibody:

Most of the antibodies used in the experiment were purchased from Cell Signaling Technology, wherein IKZF1 (#9034S), IKZF3 (#15103S), and CK1α (#ab108296) were included, and the GAPDH antibody was purchased from Abcam.

Cell Cultures

The tumor cells used herein were cultured in a cell culture medium listed in table 2 at 37° C. in an incubator with 5% CO₂. Prior to experimentation, all cells used were correctly identified by STR profiling, and tested negative for mycoplasma through routine screenings.

TABLE 2
Tumor cells and cell culture medium used in the present disclosure
Cell Line Cell culture medium used
Daudi     RPMI 1640 culture medium supplemented with 10% FBS, as
Kasumi-1  well as penicillin at a final concentration of 100 U/mL
MM. 1S    and streptomycin at a final concentration of 100 μg/mL
Ramos
MM. 1R
TMD8
SW620     L-15 culture medium supplemented with 10% FBS, as well as
          penicillin at a final concentration of 100 U/mL and
          streptomycin at a final concentration of 100 μg/mL

Determination of Half Inhibitory Concentration (IC₅₀) of the Compounds Against Tumor Cells:

IC₅₀ values of the compounds of the present disclosure (including the compounds in Table 1, and compounds of examples 1-104) were measured using the Meilun Cell Counting Kit-8 kit from Dalian Meilun Biotech Co., Ltd. Assay details are as follows: tumor cells were seeded in a 96-well plate at a density listed in Table 3. After 24 h, 100 μL of the inoculated cells were treated with 0.5 μl of the compounds of the present disclosure (including the compounds in Table 1, and compounds of examples 1-104) at 10 different successively decreasing concentrations (starting at the highest concentration of 10M; 5-fold serial dilutions). After the cells were treated with the compounds of the present disclosure for a period of time, cell viability was measured according to the instructions provided with the CCK-8 kit. DMSO served as the negative control, and corresponding commercial immunomodulatory drug Avadomide (CC-122) was used as the positive control, both of which treated the cells using the same protocol as that of the compounds of the present disclosure. The growth inhibition of the compounds of the present disclosure on cells was plotted by Prism Graphpad software, and the IC₅₀ values of the compounds of the present disclosure were calculated therefrom. Results were shown in Table 4 below.

TABLE 3
Seeding protocol and treatment time for tumor cells
		The times for treating cells
		with the compounds of the
Cells	Cells seeding protocol	present disclosure (hours)
Kasumi-1	cells were seeded in 100 μL RPMI1640 medium	72 h
MM. 1S	containing serum at a density of 10,000 cells/well
MM. 1R
TMD8	cells were seeded in 100 μL RPMI1640 medium	96 h
Ramos	containing serum at a density of 10,000 cells/well
Daudi	cells were seeded in 100 μL RPMI1640 medium	96 h
	containing serum at a density of 4000 cells/well
SW620	cells were seeded in 100 μL L-15 medium	96 h
	containing serum at a density of 4000 cells/well

Western Blotting Assay

Tumor cells were plated in a 24-well plate at a cell seeding density of 3×10⁵ cells/mL, with 1 mL culture media per well. After 24 h, the cells were treated with different concentrations of the compounds of the present disclosure. After 16 hours, the cells were collected, and washed with PBS. The supernatant was discarded, and the cells were placed on ice, and treated with RIPA protein lysate containing Halt protease and phosphatase inhibitor. The lysate was centrifuged at 10000 RPM at 4° C. for 10 minutes, and the supernatant was collected. An equal amount of proteins were loaded in 4×SDS sample solution, denatured at 95° C. for 5 minutes, and then freezed to −20° C. or directly subjected to protein electrophoresis (4-15% gradient gel, Bio-rad). Electrophoresis apparatus and related components were purchased from Bio-rad company, and electrophoresis set at a constant pressure of 120V for 1 h. Then transferring membrane was conducted by using PVDF (polyvinylidene fluoride) at 400 mA for 1 h on ice. Afterwards, the membranes were block for 30 minutes by using the TarKara Blocking Buffer at room temperature. Western blotting was conducted according to the antibody product manual of Cell Signaling Technology Company.

DC₅₀ value (the drug concentration required for degrading proteins by 50%, abbreviated as DC₅₀) reads method: comparing the gray values of the Western blotting bands for the drug treatment with the gray values of the Western blotting band for the DMSO control, and reading the drug concentration range corresponding to the gray value of the Western blotting bands for the drug treatment which is equal to half of the gray value of the Western blotting band for the DMSO control.

DC₅₀ value could also be calculated as follows: using software ImageJ to quantify the gray values of the Western blotting bands for the drug treatment, fitting the relationship curve between drug concentrations and gray values, and from the fitted curve, calculating the drug concentration corresponding to half of the gray value of the Western blotting band for the DMSO control.

Evaluation of TNF-α Inhibition Effect

PBMC cells were cultured at 37° C. in 5% CO₂ atmosphere, and then seeded in 96-well plates at 1×10⁷ cells/well. Compounds (including compounds in Table 1 and Examples 1-104 compounds) were dissolved in DMSO and diluted to corresponding concentrations so that the final concentration of DMSO added to the cell culture did not exceed 0.5%. Cells were incubated in medium with or without compounds for 1 h, then stimulated with lipopolysaccharide (LPS; 1 ng/ml), and continually cultured for 18-20 h. Then, the supernatant was collected, diluted with serum-free medium, and tested for TNF-α level by ELISA kit. IC₅₀ was then calculated by Graphpad Prism 7.0.

Determination of CRBN-Binding Affinity of Compounds

The CEREBLON BINDING kits (specification: 10,000 tests; product number: Catalog #64BDCRBNPEH; CISBIO company) was used to determine the CRBN binding ability of the compounds to be tested through a HTRF method (homogeneous time-resolved fluorescence). The specific methods are as follows:

• • 1. According to the instructions of the CEREBLON BINDING kits, the compounds to be tested of the present invention and lenalidomide were serially diluted using diluent #9 (1×) solution to obtain a final concentration of 2 μM for both the tested compounds and lenalidomide solution.
  • 2.2.5 μL of the above 2 μM of the tested compounds and lenalidomide solution, as well as the same volume of diluent #9 (1×) solution (solvent control group, Std0) were taken and added to each well of a 96-well plate, respectively. Then, 2.5 μL of (human Cereblon WT GST-tagged protein) solution was added to each well. Finally, 5 μL of the uniformly mixed thalidomide-Red reagent and GST Eu antibody working solution were added to each of the above wells. The final concentration of the tested compounds and lenalidomide in each well is 0.5 μM.
  • 3. The blank control wells were sequentially added with 2.5 μL of diluent #9 (1×) solution, 2.5 μL of PROTAC binding buffer, and 5 μL of uniformly mixed thalidomide-Red reagent and GST Eu antibody working solution.
  • 4. After sealing and incubating the solutions in the above wells at room temperature for 3 hours, the absorbance values at emission wavelengths of 620 nm and 665 nm were detected by the HTRF method using a Spark microplate reader (V3.1 SP1).

The corresponding CRBN binding inhibition rate was calculated using the following method:

$R_{\mathrm{compound}}=\mathrm{OD}665{\mathrm{nm}}_{\mathrm{compound}}/\mathrm{OD}620{\mathrm{nm}}_{\mathrm{compound}}-\mathrm{OD}665{\mathrm{nm}}_{con\mathrm{trol}}/\mathrm{OD}620{\mathrm{nm}}_{con\mathrm{trol}}$ $R_{\mathrm{Std}0}=\mathrm{OD}665{\mathrm{nm}}_{\mathrm{Std}0}/\mathrm{OD}620{\mathrm{nm}}_{\mathrm{Std}0}-\mathrm{OD}665{\mathrm{nm}}_{con\mathrm{trol}}/\mathrm{OD}620{\mathrm{nm}}_{con\mathrm{trol}}$ $\mathrm{inhibition}\mathrm{rate}\left(\%\right)=\left(1-R_{\mathrm{compound}}/R_{\mathrm{Std}0}\right)*100$

Note: OD 665 nm_compound is the absorbance value of each well of the compounds to be tested of the present disclosure at an emission wavelength of 665 nm.

OD 620 nm_compound is the absorbance value of each well of the compounds to be tested of the present disclosure at an emission wavelength of 620 nm.

OD 665 nm_control is the absorbance value of the blank control well at an emission wavelength of 665 nm.

OD 620 nm_control is the absorbance value of the blank control well at an emission wavelength of 620 nm.

OD 665 nm_std0 is the absorbance value of the solvent control well at an emission wavelength of 665 nm.

OD 620 nm_std0 is the absorbance value of the solvent control well at an emission wavelength of 620 nm.

Experimental Results

Based on immunomodulatory drugs, this study developed the compounds of the present invention. By selecting the compounds designed and developed based on immunomodulatory drugs including avadomide (CC-122) (including the compounds in Table 1 and compounds in Examples 1-104) for cellular inhibition studies, it was found that many compounds of the present invention exhibited better inhibitory activity against multiple myeloma cells MM.1S, MM.1R, and human diffuse large B-cell lymphoma cells TMD8, etc. The compounds of the present invention not only exhibit activity in inhibiting the proliferation of tumor cells but also have the ability to promote the degradation of IKZF proteins and inhibit the production of TNF-α, thus making them potential therapeutic agents for patients with immune-related tumors. The specific experimental data are shown below.

Proliferation Inhibition of the Compounds of the Present Invention Based on Avadomide (CC-122) in Tumor Cells

We tested the activities of the compounds of the present invention (including the compounds in Table 1 and Examples 1-104 compounds) in tumor cells through a dose-dependent manner. The cells were treated with the compounds of the present invention at 10 different successively decreasing concentrations (starting at the highest concentration of 10 μM; 5-fold serial dilutions) for 72 h or 96 h, and then the cell viability determination was performed in accordance with CCK-8 reagent operating instructions. Results were shown in Table 4. It showed that the compounds of the present invention inhibited tumor cells to different degrees, and some compounds of the present invention exhibited significantly stronger inhibitory effects as compared with CC-122.

TABLE 4
IC50 values (half inhibitory concentration) of the compounds
of the present invention in tumor cells (IC50, nM)
Compound	MM. 1S/	MM. 1R/	TMD8/	SW620/	Ramos/	Daudi/	Kasumi-1/
No.	IC50(nM)	IC50(nM)	IC50(nM)	IC50(nM)	IC50(nM)	IC50(nM)	IC50(nM)
CC-122	46.9	464.4	890.3	>10000	1326.0	1653.2	>10000
GT-03306	29.3	12.7	86.5	18.6	89.3	44.9	22.3
GT-03387	—	275.8	204.0	—	489.7	285.6	—
GT-03301	79.6	32.8	185.8	35.8	164.7	155.4	104.1
GT-03388	—	352.3	—	—	—	—	—
GT-01818	—	—	553.6	—	—	—	—
GT-02235	39.5	—	145.9	—	—	—	—
GT-02237	3.3	—	8.2	—	—	—	—
GT-02494	—	—	184.5	—	—	—	—
GT-02495	—	9.8	21.4	—	—	—	—
GT-02598	17.2	—	—	—	—	—	—
GT-02767	69.9	—	309.4	—	—	—	—
GT-02768	98.1	—	293.7	—	—	—	—
GT-02772	—	—	448.2	—	—	—	—
GT-02773	—	—	440.4	—	—	—	—
GT-02774	—	—	102.3	—	—	—	—
GT-02797	—	—	311.5	—	—	—	—
GT-02323	—	—	651.7	—	—	—	—
GT-02279	—	—	437.8	—	—	—	—
GT-02280	—	—	409.1	—	—	—	—
GT-02393	—	—	457.8	—	—	—	—
GT-02496	—	—	474.4	—	—	—	—
GT-03697	—	204.3	—	—	652.5	545.5	693.6
GT-04246	—	—	412.7	386.8	—	—	—
GT-03305	—	—	—	717.0	—	—	—
GT-03314	—	—	—	708.8	—	—	—
GT-03235	—	—	—	—	398.0	—	—
symbol “—” indicates undetected

The results of the binding affinity assay for the compounds of the present invention to CRBN were listed in Table 5 below.

TABLE 5
HTRF inhibitory activity (IC50, μM) of the compounds
of the present invention (including the compounds
in Table 1 and Examples 1-104 compounds)
		HTRF		HTRF
	Compound No.	IC50 (uM)	Compound No.	IC50 (uM)
	CC-122	1.07	GT-02645	2.8
	GT-02237	0.95	GT-03306	1.57
	GT-02326	0.70	GT-02759	0.05
	GT-02494	0.46	GT-02797	0.18
	GT-02495	0.32	GT-02799	2.47
	GT-02502	1.80	GT-02800	3.40
	GT-02598	3.66	GT-02234	3.34
	GT-02601	2.82	GT-02389	0.78
	GT-02621	1.04	GT-03301	1.72
	GT-02622	2.48	GT-02496	0.42
	GT-02623	2.52	GT-02392	0.99
	GT-02767	1.05	GT-02393	0.42
	GT-02768	0.68	GT-02774	2.61
	GT-02773	2.80	GT-02497	0.66
	GT-04231	3.24	GT-03305	1.20
	GT-03315	1.98	GT-03261	1.00
	GT-03317	3.58	GT-03262	1.00
	GT-03227	2.24	GT-03228	1.84
	GT-03259	2.15	GT-03235	2.40
	GT-03230	2.75	GT-03233	2.24

The experimental results indicated that the compounds of the present invention exhibit lower or comparable IC₅₀ values compared to CC-122, demonstrating stronger or equivalent binding affinity to CRBN. The differences in binding affinity may lead to the recruitment of distinct substrate proteins upon binding to CRBN and induce their degradation, resulting in different target selectivity and potentially treating different diseases.

The basic principles, main features and advantages of the present disclosure are shown and described above. Those skilled in the art should understand that the present disclosure is not limited by the foregoing embodiments, and they can make various changes, substitutions and alterations herein without departing from the spirit and scope of the present disclosure. These changes, substitutions and alterations fall within the scope of the present disclosure. The claimed scope of the present disclosure is defined by the appended claims and their equivalents.

Claims

1. A compound of Formula (I)

2. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein the compound of Formula (I) is also of Formula (II) or Formula (III):

3. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein the compound of Formula (I) is also of Formula (Ia), Formula (Ib), Formula (Ic), Formula (Id), Formula (IIa), Formula (IIb), Formula (IIc), Formula (IId), Formula (IIIa), Formula (IIIb), Formula (IIIc), or Formula (IIId):

4. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Ra represents the following formula: Ra1—X2-L1-X1—,wherein X1 represents optionally substituted C3-20 cycloalkylene, optionally substituted 4- to 20-membered nitrogen-containing heterocyclylene, optionally substituted C6-10 arylene, or optionally substituted 5- to 20-membered heteroarylene;L1 represents optionally substituted linear or branched C1-60 alkylene, or optionally substituted linear or branched C2-60alkylene with one or more groups Rd1 and/or one or more groups Rd2 and/or any combination of one or more groups Rd1 and Rd2 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rd1, Rd2, or a combination of Rd1 and Rd2; wherein each Rd1 is independently selected from the group consisting of O, S, N(Rd3), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein Rd3 independently represents H or C1-3 alkyl, and in case that two or more groups Rd1 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups Rd1 are not directly connected to each other; and wherein each Rd2 is independently selected from the group consisting of optionally substituted C3-15 cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH—, halogenated C1-6 alkyl, NH2—C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)—, optionally deuterated C1-6 alkyl-C(O)NH— or any combination thereof, wherein the linear or branched C1-60 alkylene and the linear or branched C2-60 alkylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, or any combination thereof;X2 represents a bond; andRa1 represents NRd4Rd5, C(O)NRd6Rd7, NHC(O)Rd8, NHC(O)NRd9Rd10, C(O)ORd11, OC(O)Rd12, ORd13, SRd14, C(O)Rd15, C(S)Rd16, S(O)Rd17, S(O)2Rd18, S(O)2NHRd19, NHS(O)2Rd20, S(O)2ORd21, OS(O)2Rd22, optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C6-20 aryl or optionally substituted 5- to 20-membered heteroaryl, wherein Rd4, Rd5, Rd6, Rd7, Rd9, Rd10, Rd11, Rd13, Rd14, Rd19 and Rd21 are the same or different and each independently represent H, optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, and Rd8, Rd12, Rd15, Rd16, Rd17, Rd15, Rd20 and Rd22 each independently represent optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C6-20 aryl or optionally substituted 5- to 20-membered heteroaryl;andRb represents C1-60 alkyl optionally substituted with D or halogen, orRb represents the following formula: Rb1—X4-L2-,wherein L2 represents: linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6cycloalkyl or any combination thereof, oroptionally substituted linear or branched C2-60 alkylene with one or more groups R12 and/or one or more groups R13 and/or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, cyano or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof;X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; andRb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof.

5. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Ra represents the following formula: Ra1—X2-L1-X1—,wherein X1 represents N(Re1), O, S, C2-6 alkynylene, C2-6 alkenylene, optionally substituted C3-20 cycloalkylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted C6-15 arylene, or optionally substituted 5- to 20-membered heteroarylene, wherein Re1 represents H or C1-3 alkyl, or X1 represents a bond; L1 represents optionally substituted linear or branched C1-60 alkylene, or optionally substituted linear or branched C2-60alkylene with one or more groups Re2 and/or one or more groups Re3 and/or any combination of one or more groups Re2 and Re3 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Re2, Re3, or a combination of Re2 and Re3; wherein each Re2 is independently selected from the group consisting of O, S, N(Re4), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH, or NHS(O)2, wherein Re4 represents H or C1-3 alkyl, and in case that two or more groups Re2 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups Re2 are not directly connected to each other; and wherein each Re3 is independently selected from the group consisting of optionally substituted C3-15 cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the linear or branched C1-60 alkylene and the linear or branched C2-60 alkylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, or any combination thereof;X2 represents C(O) or S(O)2, or X2 represents a bond;Ra1 represents the following formula:

6. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Ra represents the following formula: Ra1—X2-L1-X1—,wherein X1 represents a bond, or X1 represents N(R1), O, S, C2-6 alkynylene or C2-6 alkenylene, wherein R1 represents H or C1-3 alkyl; L1 represents linear or branched C1-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy, or any combination thereof,X2 represents a bond, or X2 represents N(R2), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH—, —NH-triazolylene, or optionally substituted phenylene, wherein R2 represents H or C1-3 alkyl, and the 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms is optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, oxo, hydroxy, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, cyano, or any combination thereof, and the phenylene is optionally substituted with 1 to 4 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, cyano, or any combination thereof; andRa1 represents hydroxy, optionally substituted adamantanyl, optionally substituted noradamantanyl, optionally substituted cubanyl, optionally substituted spirocycloalkyl, optionally substituted bicyclo[2.2.2]octan-1-yl, optionally substituted bicyclo[2.2.2]octan-2-yl, optionally substituted bornyl, optionally substituted bicyclo[2.2.1]heptanyl, optionally substituted bicyclo[2.2.1]heptenyl, optionally substituted p-menthanyl or optionally substituted m-menthanyl, wherein when Ra1 represents hydroxy, X2 represents a bond, and the adamantanyl, noradamantanyl, cubanyl, spirocycloalkyl, bicyclo[2.2.2]octan-1-yl, bicyclo[2.2.2]octan-2-yl, bornyl, bicyclo[2.2.1]heptanyl, bicyclo[2.2.1]heptenyl, p-menthanyl and m-menthanyl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;andRb represents C1-60 alkyl optionally substituted with D or halogen, orRb represents the following formula: Rb1—X4-L2-,wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, oroptionally substituted linear or branched C2-60 alkylene with one or more groups R12 and/or one or more groups R13 and/or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, cyano or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof;X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; andRb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof.

7. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Ra represents the following formula: Ra1—X2-L1-X1—,wherein X1 represents N(R3), O or S, wherein R3 represents H or C1-3 alkyl; L1 represents linear or branched C4-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy, or any combination thereof, X2 represents a bond, or X2 represents N(R4), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, wherein R4 represents H or C1-3 alkyl; andRa1 represents optionally substituted 4- to 20-membered heterocyclyl, and the 4- to 20-membered heterocyclyl is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C3-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C3-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;andRb represents C1-60 alkyl optionally substituted with D or halogen, orRb represents the following formula: Rb1—X4-L2-,wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, oroptionally substituted linear or branched C2-60 alkylene with one or more groups R12 and/or one or more groups R13 and/or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH— or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof;X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; andRb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C3-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof.

8. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Ra represents the following formula: Ra1—X2-L1-X1—,wherein X1 represents a bond, or X1 represents C2-6 alkynylene or C2-6 alkenylene; L1 represents linear or branched C1-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, C1-6 alkoxy, or any combination thereof; andX2 represents a bond, or X2 represents N(R5), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, wherein R5 represents H or C1-3 alkyl; andRa1 represents optionally substituted 4- to 20-membered heterocyclyl, wherein the 4- to 20-membered heterocyclyl is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;andRb represents C1-60 alkyl optionally substituted with D or halogen, orRb represents the following formula: Rb1—X4-L2-,wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, oroptionally substituted linear or branched C2-60 alkylene with one or more groups R12 and/or one or more groups R13 and/or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH— or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof;X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; andRb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof.

9. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Ra represents the following formula: Ra1—X2-L1-X1—,wherein X1 represents a bond, or X1 represents N(R6), O, S, C2-6 alkynylene, or C2-6 alkenylene, wherein R6 represents H or C1-3 alkyl; L1 represents optionally substituted linear or branched C2-60 alkylene with one or more groups R7 and/or one or more groups R8 and/or any combination of one or more groups R7 and R8 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R7, R8, or a combination of R7 and R8; wherein each R7 is independently selected from the group consisting of O, S, N(R9), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R9 represents H or C1-3 alkyl, and in case that two or more groups R7 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R7 are not directly connected to each other; and wherein each R8 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, triazolylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene and the triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, C1-6 alkoxy, or any combination thereof, X2 represents a bond, or X2 represents N(R10), C(O)O, OC(O), C(O)NH, NHC(O), C(O), 0, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms, triazolylene, triazolylene-NH—, —NH-triazolylene, or optionally substituted phenylene, wherein R10 represents H or C1-3 alkyl, and the 4- to 8-membered heterocyclylene containing 1 to 2 nitrogen atoms is optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, oxo, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the phenylene is optionally substituted with 1 to 4 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; andRa1 represents hydroxy, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted C3-20 cycloalkyl, wherein when Ra1 represents hydroxy, X2 represents a bond, and the 4- to 20-membered heterocyclyl and the C3-20 cycloalkyl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;andRb represents C1-60 alkyl optionally substituted with D or halogen, orRb represents the following formula: Rb1—X4-L2-,wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, oroptionally substituted linear or branched C2-60 alkylene with one or more groups R12 and/or one or more groups R13 and/or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; andRb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, C1-3 alkoxy, C1-3 alkyl-NH—, halogenated C1-3 alkyl, NH2—C1-3 alkylene, C1-3 alkyl-NHC(O)—, C1-3 alkyl-C(O)NH—, cyano or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof.

10. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Ra represents the following formula: Ra2—X3—,wherein X3 represents N(R11), C(O)O, OC(O), C(O)NH, NHC(O), O, S, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 5- to 20-membered heteroarylene or optionally substituted 4- to 20-membered heterocyclylene, wherein R11 represents H or C1-3 alkyl, wherein the C3-20 cycloalkylene and the 4- to 20-membered heterocyclylene are each independently optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, oxo, or any combination thereof, and the C6-20 arylene and the 5- to 20-membered heteroarylene are each independently optionally substituted with 1 to 8 substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, or any combination thereof, andRa2 represents optionally substituted C3-20 cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted 5- to 20-membered heteroaryl or optionally substituted C6-20 aryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;andRb represents C1-60 alkyl optionally substituted with D or halogen, orRb represents the following formula: Rb1—X4-L2-,wherein L2 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, oroptionally substituted linear or branched C2-60 alkylene with one or more groups R12 and/or one or more groups R13 and/or any combination of one or more groups R12 and R13 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R12, R13, or a combination of R12 and R13; wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R14 independently represents H or C1-3 alkyl, and in case that two or more groups R12 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R12 are not directly connected to each other; and wherein each R13 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof,X4 represents a bond, or X4 represents N(R15), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted C3-20 cycloalkylene, optionally substituted C6-20 arylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted 5- to 20-membered heteroarylene, triazolylene-NH—, or —NH-triazolylene, wherein R15 represents H or C1-3 alkyl, and the C3-20 cycloalkylene, the C6-20 arylene, the 4- to 20-membered heterocyclylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; andRb1 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof.

11. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Ra represents halogen or cyano, andRb represents the following formula: Rb2—X5-L3-,wherein L3 represents linear or branched C2-60 alkylene optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, oroptionally substituted linear or branched C2-60 alkylene with one or more groups R16 and/or one or more groups R17 and/or any combination of one or more groups R16 and R17 inserted into its backbone carbon chain, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R16, R17, or a combination of R16 and R17; wherein each R16 is independently selected from the group consisting of O, S, N(R18), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein R18 represents H or C1-3 alkyl, and in case that two or more groups R16 are inserted into the backbone carbon chain of the linear or branched C2-60 alkylene group, the two or more groups R16 are not directly connected to each other; and wherein each R17 is independently selected from the group consisting of C3-15 cycloalkylene, 4- to 15-membered heterocyclylene, C6-10 arylene, 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15 cycloalkylene, the 4- to 15-membered heterocyclylene, C6-10 arylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the linear or branched C2-60 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, C1-4 alkyl, halogen, C3-6 cycloalkyl or any combination thereof, X5 represents N(R19), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, wherein R19 represents H or C1-3 alkyl, or X5 represents a bond; andRb2 represents optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the C3-20 cycloalkyl, the C6-20 aryl, the 4- to 20-membered heterocyclyl, and the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15 cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; orRb2 represents the following formula:

12. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 4, wherein X1 represents optionally substituted C3-20 cycloalkylene, optionally substituted 4- to 20-membered nitrogen-containing monocyclic heterocyclylene, optionally substituted 5- to 20-membered nitrogen-containing bridged heterocyclylene, optionally substituted 5- to 20-membered nitrogen-containing spiro-heterocyclylene, optionally substituted 5- to 20-membered nitrogen-containing fused heterocyclylene, optionally substituted C6-10 arylene, or optionally substituted 5- to 20-membered heteroarylene, wherein the C3-20 cycloalkylene, the 4- to 20-membered nitrogen-containing monocyclic heterocyclylene, the 5- to 20-membered nitrogen-containing bridged heterocyclylene, the 5- to 20-membered nitrogen-containing spiro-heterocyclylene, the 5- to 20-membered nitrogen-containing fused heterocyclylene, the C6-10 arylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; orRa1 represents NRd4Rd5, C(O)NRd6Rd7, NHC(O)Rd8, NHC(O)NRd9Rd10, C(O)ORd11, OC(O)Rd12, ORd13, SRd14, C(O)Rd15, C(S)Rd16, S(O)Rd17, S(O)2Rd18, S(O)2NHRd19, NHS(O)2Rd20, S(O)2ORd21, OS(O)2Rd22, optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20 cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C6-20 aryl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C1-10 alkyl, the C3-20 cycloalkyl, the 4- to 20-membered heterocyclyl, the C6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof; wherein Rd4, Rd5, Rd6, Rd7, Rd9, Rd10, Rd11, Rd13, Rd14, Rd19 and Rd21 each independently represent H, optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20 cycloalkyl, optionally substituted C6-20 aryl, optionally substituted 4- to 20-membered heterocyclyl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C1-10 alkyl, the C3-20 cycloalkyl, the 4- to 20-membered heterocyclyl, the C6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof; andRd8, Rd12, Rd15, Rd16, Rd17, Rd15, Rd20 and Rd22 each independently represent optionally substituted linear or branched C1-10 alkyl, optionally substituted C3-20 cycloalkyl, optionally substituted 4- to 20-membered heterocyclyl, optionally substituted C6-20 aryl or optionally substituted 5- to 20-membered heteroaryl, wherein the linear or branched C1-10 alkyl, the C3-20 cycloalkyl, the 4- to 20-membered heterocyclyl, the C6-20 aryl or the 5- to 20-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof;preferably, wherein X1 represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene or bicyclo[2.2.1]heptenylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;phenylene or naphthylene, wherein the phenylene or naphthylene is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, azepanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanylene, 3,6-diazabicyclo[3.1.1]heptanylene, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; orfuranylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene, and imidazo[2,1-b]thiazolylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;or Ra1 represents NRd4Rd5, C(O)NRd6Rd7, NHC(O)Rd8, NHC(O)NRd9Rd10, C(O)ORd11, OC(O)Rd12, ORd13, SRd14, C(O)Rd15, C(S)Rd16, S(O)Rd17, S(O)2Rd18, S(O)2NHRd19, NHS(O)2Rd20, S(O)2ORd21, or OS(O)2Rd22, wherein Rd4, Rd5, Rd6, Rd7, Rd9, Rd10, Rd11, Rd13, Rd14, Rd19 and Rd21 are the same or different and each independently represent: H, ormethyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; orcyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; orphenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of optionally deuterated C1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; orazetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof;furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; andRd8, Rd12, Rd15, Rd16, Rd17, Rd15, Rd20 and Rd22 each independently represent: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; orcyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; orphenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; orazetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof;furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof;orRa1 represents: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl or decyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; orcyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; orphenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; orazetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof; orfuranyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted 5- to 15-membered heteroaryl or any combination thereof, wherein the optionally substituted C3-15cycloalkyl, optionally substituted C6-10 aryl, optionally substituted 4- to 15-membered heterocyclyl and optionally substituted 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, hydroxy, cyano, amino, mercapto, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene or any combination thereof.

13. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 5, wherein (i) X1 represents a bond, or X1 represents N(Re1), O, S, C2-6 alkynylene, C2-6 alkenylene, optionally substituted C3-20cycloalkylene, optionally substituted 4- to 20-membered heterocyclylene, optionally substituted C6-15 arylene, or optionally substituted 5- to 20-membered heteroarylene, wherein Re1 represents H or C1-3 alkyl, wherein the C3-20 cycloalkylene, the 4- to 20-membered heterocyclylene, the C6-15 arylene, and the 5- to 20-membered heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;preferably, wherein X1 represents a bond, orX1 represents N(Re1), O, S, C2-6 alkynylene or C2-6 alkenylene, wherein Re1 represents H or C1-3 alkyl;orX1 represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydropentalenylene, octahydro-1H-indenylene, spiro[3.3]heptylene, spiro[2.5]octylene, spiro[3.5]nonylene, spiro[4.4]nonylene, spiro[4.5]decylene, spiro[5.5]undecylene, p-menthanylene, m-menthanylene, quinuclidinylene, adamantanylene, noradamantanylene, bornylene, bicyclo[2.2.1]heptanylene, 2-oxobicyclo[2.2.1]heptanylene or bicyclo[2.2.1]heptenylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;phenylene or naphthylene, wherein the phenylene or naphthylene is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof,azetidinylene, oxetanylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, tetrahydrofuranylene, tetrahydropyranylene, tetrahydrothienylene, tetrahydrothiopyranylene, oxazolidinylene, thiazolidinylene, piperidinylene, piperazinylene, morpholinylene, thiomorpholinylene, dioxacyclohexylene, azacycloheptanylene, azacyclooctylene, diazacycloheptanylene, diazacyclooctylene, 3-azabicyclo[3.1.0]hexylene, 6-azabicyclo[3.1.1]heptanylene, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octylene, 3,8-diazabicyclo[3.2.1]octylene, 2,5-diazabicyclo[2.2.2]octylene, 3-azaspiro[5.5]undecylene or 7-azaspiro[3.5]nonylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; orfuranylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazolylene or imidazo[2,1-b]thiazolylene, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, halogenated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;or(ii) Ra1 represents the following formula:

14. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 6, wherein Ra1 represents: hydroxy, wherein when Ra1 represents hydroxy, X2 represents a bond; oradamantan-1-yl, adamantan-2-yl, adamantan-3-yl, adamantan-4-yl, adamantan-5-yl, adamantan-6-yl, adamantan-7-yl, adamantan-8-yl, adamantan-9-yl, adamantan-10-yl, noradamantan-1-yl, noradamantan-2-yl, noradamantan-3-yl, noradamantan-4-yl, noradamantan-5-yl, noradamantan-6-yl, noradamantan-7-yl, noradamantan-8-yl, noradamantan-9-yl, cubanyl, C5-15 spirocycloalkyl, bicyclo[2.2.2]octan-1-yl, bicyclo[2.2.2]octan-2-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-3-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-4-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-5-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-6-yl,

15. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Ra1 represents: azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 1,3-diazacycloheptanyl, 1,4-diazacycloheptanyl, 4,5-diazacycloheptanyl, 5- to 15-membered bridged heterocyclyl (e.g., 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, diazabicyclo[3.2.1]octyl, diazabicyclo[2.2.2]octyl, 3,8-diazabicyclo[3.2.1]octan-3-yl, and 2,5-diazabicyclo[2.2.2]octan-2-yl), or 5- to 15-memberedazaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecylene and 7-azaspiro[3.5]nonylene), with each group being independently optionally substituted with one or more substituents selected from the group consisting of: D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof.

16. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 9, wherein Ra1 represents: Ra1 represents hydroxy, and X2 represents a bond; or Ra1 represents: azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 1,3-diazacycloheptanyl, 1,4-diazacycloheptanyl, 4,5-diazacycloheptanyl, 5- to 15-membered bridged heterocyclyl (e.g., 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, diazabicyclo[3.2.1]octyl, diazabicyclo[2.2.2]octyl, 3,8-diazabicyclo[3.2.1]octan-3-yl, and 2,5-diazabicyclo[2.2.2]octan-2-yl), or 5- to 15-memberedazaspirocycloalkyl (e.g., 3-azaspiro[5.5]undecylene and 7-azaspiro[3.5]nonylene), with each group being independently optionally substituted with one or more substituents selected from the group consisting of: D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; orcyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being independently optionally substituted with one or more substituents selected from the group consisting of: D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof.

17. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 10, wherein Ra2 represents: cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; orfuranyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof.

18. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 4, wherein X1 represents:

19. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 5, wherein X1 represents a bond, or X1 represents NH, N(CH3), O, S, ethynylene or vinylene, orX1 represents:

20. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 6, wherein Ra1 represents hydroxy, and X2 represents a bond; orRa1 represents:

21. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Ra1 represents:

22. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 9, wherein Ra1 represents:

23. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 10, wherein Ra2—X3— represents:

24. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 4, wherein L1 represents the following formula: ##—(C(Ra1)(Ra2))m1—(Rd1(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(Rd1(C(Ra3)(Ra4))m2)p1—(Rd1(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(Rd1(C(Ra3)(Ra4))m2)p1—(Rd1(C(Rd5)(Ra6))m3)p2—(Rd1(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(Rd2(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(Rd2(C(Ra3)(Ra4))m2)p1—(Rd2(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(Rd2(C(Ra3)(Ra4))m2)p1—(Rd2(C(Ra5)(Ra6))m3)p2—(Rd2(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(Rd1—Rd2—(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(Rd1(C(Ra3)(Ra4))m2)p1—(Rd2(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(Rd2—Rd1—(C(Ra3)(Ra4))m2)p1—; or##—(C(Ra1)(Ra2))m1—(Rd2(C(Ra3)(Ra4))m2)p1—(Rd1(C(Ra5)(Ra6))m3)p2—;wherein each Rd1 is independently selected from the group consisting of O, S, N(Rd3), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein each Rd3 independently represents H or C1-3 alkyl; and each group Rd2 is independently selected from the group consisting of optionally substituted C3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH—, halogenated C1-6 alkyl, NH2—C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)—, optionally deuterated C1-6 alkyl-C(O)NH— or any combination thereof;Raa1, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH—, NH2—C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)—, optionally deuterated C1-6 alkyl-C(O)NH— or any combination thereof,symbol ## indicates the point of attachment to X1; andm1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

25. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 5, wherein L1 represents the structure of the following formula: ##—(C(Ra1)(Ra2))m1—(Re2(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(Re2(C(Ra3)(Ra4))m2)p1—(Re2(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(Re2(C(Ra3)(Ra4))m2)p1—(Re2(C(Ra5)(Ra6))m3)p2—(Re2(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(Re3(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(Re3(C(Ra3)(Ra4))m2)p1—(Re3(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(Re3(C(Ra3)(Ra4))m2)p1—(Re3(C(Ra5)(Ra6))m3)p2—(Re3(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(Re2—Re3—(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(Re2(C(Ra3)(Ra4))m2)p1—(Re3(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(Re3—Re2—(C(Ra3)(Ra4))m2)p1—; or##—(C(Ra1)(Ra2))m1—(Re3(C(Ra3)(Ra4))m2)p1—(Re2(C(Ra5)(Ra6))m3)p2—;wherein each Re2 is independently selected from the group consisting of O, S, N(Re4), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein each Re4 independently represents H or C1-3 alkyl; andeach group Re3 is independently selected from the group consisting of optionally substituted C3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH—, halogenated C1-6 alkyl, NH2—C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)—, optionally deuterated C1-6 alkyl-C(O)NH— or any combination thereof;Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH—, NH2—C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)—, optionally deuterated C1-6 alkyl-C(O)NH— or any combination thereof, symbol ## indicates the point of attachment to X1; andm1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

26. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein L1 represents the structure of the following formula: ##—(C(Ra1)(Ra2))m1—(O(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(O(C(Ra3)(Ra4))m2)p1—(O(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(O(C(Ra3)(Ra4))m2)p1—(O(C(Ra5)(Ra6))m3)p2—(O(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(N(Rg9)(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(N(Rg9)(C(Ra3)(Ra4))m2)p1—(N(Rg9)(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(N(Rg9)(C(Ra3)(Ra4))m2)p1—(N(Rg9)(C(Ra5)(Ra6))m3)p2—(N(Rg9)(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(C(O)NH—(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(C(O)NH—(C(Ra3)(Ra4))m2)p1—(C(O)NH—(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(C(O)NH—(C(Ra3)(Ra4))m2)p1—(C(O)NH—(C(Ra5)(Ra6))m3)p2—(C(O)NH—(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(C(O)NH—(C(Ra3)(Ra4))m2)p1—(O—(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1(—C(O)NH—(C(Ra3)(Ra4))m2—(O(C(Ra5)(Ra6))m3)p1—;##—(C(Ra1)(Ra2))m1—(NHC(O)—(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(NHC(O)—(C(Ra3)(Ra4))m2)p1—(—O—(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(NHC(O)—(C(Ra3)(Ra4))m2)p1—(O—(C(Ra5)(Ra6))m3)p2—(O—(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—NHC(O)—(C(Ra3)(Ra4))m2—(O(C(Ra5)(Ra6))m3)p1—;##—(C(Ra1)(Ra2))m1—NHC(O)NH—(C(Ra3)(Ra4))m2—;##—(C(Ra1)(Ra2))m1—C(O)—(C(Ra3)(Ra4))m2—;##—(C(Ra1)(Ra2))m1—C(S)—(C(Ra3)(Ra4))m2—;##—(C(Ra1)(Ra2))m1—S—(C(Ra3)(Ra4))m2—;##—(C(Ra1)(Ra2))m1—(C6-10 arylene-(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(C6-10 arylene-(C(Ra3)(Ra4))m2)p1—C6-10 arylene-(C(Ra5)(Ra6))m3—;##—(C(Ra1)(Ra2))m1-(4- to 15-membered heterocyclylene-(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1-(4- to 15-membered heterocyclylene-(C(Ra3)(Ra4))m2)p1-(4- to 15-membered heterocyclylene-(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1-(5- to 15-membered heteroarylene-(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1-(5- to 15-membered heteroarylene-(C(Ra3)(Ra4))m2)p1—(5- to 15-membered heteroarylene-(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(C3-15cycloalkylene-(C(Ra3)(Ra4))m2)p1—; or##—(C(Ra1)(Ra2))m1—(C3-15cycloalkylene-(C(Ra3)(Ra4))m2)p1—(C3-15cycloalkylene-(C(Ra5)(Ra6))m3)p2—;wherein each Rg9 independently represents H or C1-3 alkyl;the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH—, halogenated C1-6 alkyl, NH2—C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)—, optionally deuterated C1-6 alkyl-C(O)NH—, cyano or any combination thereof;Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH—, NH2—C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)—, optionally deuterated C1-6 alkyl-C(O)NH— or any combination thereof, symbol ## indicates the point of attachment to X1; andm1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

27. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 9, wherein L1 represents the structure of the following formula: ##—(C(Ra1)(Ra2))m1—(R7(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(R7(C(Ra3)(Ra4))m2)p1—(R7(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(R7(C(Ra3)(Ra4))m2)p1—(R7(C(Ra5)(Ra6))m3)p2—(R7(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(R8(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(R8(C(Ra3)(Ra4))m2)p1—(R8(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(R8(C(Ra3)(Ra4))m2)p1—(R8(C(Ra5)(Ra6))m3)p2—(R8(C(Ra7)(Ra))m4)p3—;##—(C(Ra1)(Ra2))m1—(R7—R8—(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(R7(C(Ra3)(Ra4))m2)p1—(R8(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(R8—R7—(C(Ra3)(Ra4))m2)p1—; or##—(C(Ra1)(Ra2))m1—(R8(C(Ra3)(Ra4))m2)p1—(R7(C(Ra5)(Ra6))m3)p2—;wherein each group R7 is independently selected from the group consisting of O, S, N(R9), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein each R9 independently represents H or C1-3 alkyl; and each R8 is independently selected from the group consisting of C3-15cycloalkylene, 4- to 15-membered heterocyclylene, triazolylene or any combination thereof, wherein the C3-15cycloalkylene, the 4- to 15-membered heterocyclylene and the triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, C1-4 alkyl, halogen, C3-6cycloalkyl or any combination thereof;symbol ## indicates the point of attachment to X1; andm1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15;preferably, wherein L1 represents the structure of the following formula: ##—(C(Ra1)(Ra2))m1—(O(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(O(C(Ra3)(Ra4))m2)p1—(O(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(O(C(Ra3)(Ra4))m2)p1—(O(C(Ra5)(Ra6))m3)p2—(O(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(N(R9)(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(N(R9)(C(Ra3)(Ra4))m2)p1—(N(R9)(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(N(R9)(C(Ra3)(Ra4))m2)p1—(N(R9)(C(Ra5)(Ra6))m3)p2—(N(R9)(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(C(O)NH—(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(C(O)NH—(C(Ra3)(Ra4))m2)p1—(C(O)NH—(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(C(O)NH—(C(Ra3)(Ra4))m2)p1—(C(O)NH—(C(Ra5)(Ra6))m3)p2—(C(O)NH—(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—(C(O)NH—(C(Ra3)(Ra4))m2)p1—(O—(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—C(O)NH—(C(Ra3)(Ra4))m2—(O(C(Ra5)(Ra6))m3)p1—;##—(C(Ra1)(Ra2))m1—(NHC(O)—(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1—(NHC(O)—(C(Ra3)(Ra4))m2)p1—(O—(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(NHC(O)—(C(Ra3)(Ra4))m2)p1—(O—(C(Ra5)(Ra6))m3)p2—(O—(C(Ra7)(Ra8))m4)p3—;##—(C(Ra1)(Ra2))m1—NHC(O)—(C(Ra3)(Ra4))m2—(O(C(Ra5)(Ra6))m3)p1—;##—(C(Ra1)(Ra2))m1—NHC(O)NH—(C(Ra3)(Ra4))m2—;##—(C(Ra1)(Ra2))m1—C(O)—(C(Ra3)(Ra4))m2—;##—(C(Ra1)(Ra2))m1—C(S)—(C(Ra3)(Ra4))m2—;##—(C(Ra1)(Ra2))m1—S—(C(Ra3)(Ra4))m2—;##—(C(Ra1)(Ra2))m1-(4- to 15-membered heterocyclylene-(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1-(4- to 15-membered heterocyclylene-(C(Ra3)(Ra4))m2)p1-(4- to 15-membered heterocyclylene-(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1-(triazolylene-(C(Ra3)(Ra4))m2)p1—;##—(C(Ra1)(Ra2))m1-(triazolylene-(C(Ra3)(Ra4))m2)p1-(triazolylene-(C(Ra5)(Ra6))m3)p2—;##—(C(Ra1)(Ra2))m1—(C3-15cycloalkylene-(C(Ra3)(Ra4))m2)p1—; or##—(C(Ra1)(Ra2))m1—(C3-15cycloalkylene-(C(Ra3)(Ra4))m2)p1—(C3-15cycloalkylene-(C(Ra5)(Ra6))m3)p2—;wherein each R9 independently represents H or C1-3 alkyl;the C3-15cycloalkylene, the 4- to 15-membered heterocyclylene and the triazolylene are each independently optionally substituted with a substituent selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH— or any combination thereof;Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, Ra7 and Ra8 each independently represent H, deuterium, C1-4 alkyl, halogen, C3-6cycloalkyl or any combination thereof;symbol ## indicates the point of attachment to X1; andm1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

28. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein L1 represents the following group: ##—CH2—O—CH2—, ##—CH2—O—(CH2)2—, ##—(CH2)1—O—(CH2)3—, ##—(CH2)1—O—(CH2)4—, ##—(CH2)1—O—(CH2)5—, ##—(CH2)1—O—(CH2)6—, ##—(CH2)1—O—(CH2)7—, ##—(CH2)1—O—(CH2)8—, ##—(CH2)1—O—(CH2)9—, ##—(CH2)1—O—(CH2)10—, ##—(CH2)2—O—(CH2)1—, ##—(CH2)2—O—(CH2)2—, ##—(CH2)2—O—(CH2)3—, ##—(CH2)2—O—(CH2)4—, ##—(CH2)2—O—(CH2)5—, ##—(CH2)2—O—(CH2)6—, ##—(CH2)2—O—(CH2)7—, ##—(CH2)2—O—(CH2)8—, ##—(CH2)2—O—(CH2)9—, ##—(CH2)2—O—(CH2)10—, ##—(CH2)2—O—(CH2)11—, ##—(CH2)2—O—(CH2)12—, ##—(CH2)3—O—(CH2)1—, ##—(CH2)3—O—(CH2)2—, ##—(CH2)3—O—(CH2)3—, ##—(CH2)3—O—(CH2)4—, ##—(CH2)3—O—(CH2)5—, ##—(CH2)3—O—(CH2)6—, ##—(CH2)3—O—(CH2)7—, ##—(CH2)4—O—(CH2)1—, ##—(CH2)4—O—(CH2)2—, ##—(CH2)4—O—(CH2)3—, ##—(CH2)4—O—(CH2)4—, ##—(CH2)4—O—(CH2)5—, ##—(CH2)4—O—(CH2)6—, ##—(CH2)5—O—(CH2)1—, ##—(CH2)5—O—(CH2)2—, ##—(CH2)5—O—(CH2)3—, ##—(CH2)5—O—(CH2)4—, ##—(CH2)5—O—(CH2)5—, ##—(CH2)6—O—(CH2)1—, ##—(CH2)6—O—(CH2)2—, ##—(CH2)6—O—(CH2)3—, ##—(CH2)6—O—(CH2)4—, ##—(CH2)7—O—(CH2)1—, ##—(CH2)7—O—(CH2)2—, ##—(CH2)7—O—(CH2)3—, ##—(CH2)8—O—(CH2)1—, ##—(CH2)8—O—(CH2)2—, ##—CH(CH3)—O—(CH2)1—, ##—CH(CH3)—O—(CH2)2—, ##—CH(CH3)—O—(CH2)3—, ##—CH(CH3)—O—(CH2)4—, ##—CH(CH3)—O—(CH2)5—, ##—CH(CH3)—O—(CH2)6—, ##—CH(CH3)—O—(CH2)7—, ##—CH(CH3)—O—(CH2)8—, ##—CH(CH3)—O—(CH2)9—, ##—CH(CH3)—O—(CH2)10—, ##—CH2—(O(CH2)2)2—, ##—CH2—(O(CH2)2)3—, ##—CH2—(O(CH2)2)4—, ##—CH2—(O(CH2)2)5—, ##—CH2—(O(CH2)2)6—, ##—CH2—(O(CH2)2)7—, ##—CH2—(O(CH2)2)8—, ##—CH2—(O(CH2)2)9—, ##—CH2—(O(CH2)2)10—, ##—CH2—(O(CH2)2)1—OCH2—, ##—CH2—(O(CH2)2)2—OCH2—, ##—CH2—(O(CH2)2)3—OCH2—, ##—CH2—(O(CH2)2)4—OCH2—, ##—CH2—(O(CH2)2)5—OCH2—, ##—CH2—(O(CH2)2)6—OCH2—, ##—CH2—(O(CH2)2)7—OCH2—, ##—CH2—(O(CH2)2)8—OCH2—, ##—CH2—(O(CH2)2)9—OCH2—, ##—CH2—(O(CH2)2)10—OCH2—, ##—(CH2)2—(O(CH2)2)2—, ##—(CH2)2—(O(CH2)2)3—, ##—(CH2)2—(O(CH2)2)4—, ##—(CH2)2—(O(CH2)2)5—, ##—(CH2)2—(O(CH2)2)6—, ##—(CH2)2—(O(CH2)2)7—, ##—(CH2)2—(O(CH2)2)8—, ##—(CH2)2—(O(CH2)2)9—, ##—(CH2)2—(O(CH2)2)10—, ##—(CH2)3—(O(CH2)2)2—, ##—(CH2)3—(O(CH2)2)3—, ##—(CH2)3—(O(CH2)2)4—, ##—(CH2)3—(O(CH2)2)5—, ##—(CH2)3—(O(CH2)2)6—, ##—(CH2)3—(O(CH2)2)7—, ##—(CH2)3—(O(CH2)2)8—, ##—(CH2)3—(O(CH2)2)9—, ##—(CH2)3—(O(CH2)2)10—, ##—(CH2)4—(O(CH2)2)2—, ##—(CH2)4—(O(CH2)2)3—, ##—(CH2)4—(O(CH2)2)4—, ##—(CH2)4—(O(CH2)2)5—, ##—(CH2)4—(O(CH2)2)6—, ##—(CH2)4—(O(CH2)2)7—, ##—(CH2)4—(O(CH2)2)8—, ##—(CH2)4—(O(CH2)2)9—, ##—(CH2)4—(O(CH2)2)10—, ##—CH2—(O(CH2)3)2—, ##—CH2—(O(CH2)3)3—, ##—CH2—(O(CH2)3)4—, ##—CH2—(O(CH2)3)5—, ##—CH2—(O(CH2)3)6—, ##—CH2—(O(CH2)3)7—, ##—CH2—(O(CH2)3)8—, ##—CH2—(O(CH2)3)9—, ##—CH2—(O(CH2)3)10—, ##—(CH2)2—(O(CH2)3)2—, ##—(CH2)2—(O(CH2)3)3—, ##—(CH2)2—(O(CH2)3)4—, ##—(CH2)2—(O(CH2)3)5—, ##—(CH2)2—(O(CH2)3)6—, ##—(CH2)2—(O(CH2)3)7—, ##—(CH2)2—(O(CH2)3)8—, ##—(CH2)2—(O(CH2)3)9—, ##—(CH2)2—(O(CH2)3)10—, ##—(CH2)3—(O(CH2)3)2—, ##—(CH2)3—(O(CH2)3)3—, ##—(CH2)3—(O(CH2)3)4—, ##—(CH2)3—(O(CH2)3)5—, ##—(CH2)3—(O(CH2)3)6—, ##—(CH2)3—(O(CH2)3)7—, ##—(CH2)3—(O(CH2)3)8—, ##—(CH2)3—(O(CH2)3)9—, ##—(CH2)3—(O(CH2)3)10—, ##—CH2—O—(CH2)2—O—(CH2)3—, ##—CH2—(O(CH2)2)2—(O(CH2)3)2—, ##—CH2—(O(CH2)2)3—(O(CH2)3)3—, ##—CH2—(O(CH2)2)4—(O(CH2)3)4—, ##—CH2—(O(CH2)2)5—(O(CH2)3)5—, ##—CH2—(O(CH2)2)6—(O(CH2)3)6—, ##—(CH2)2—O—(CH2)2—O—(CH2)3—, ##—(CH2)2—(O(CH2)2)2—(O(CH2)3)2—, ##—(CH2)2—(O(CH2)2)3—(O(CH2)3)3—, ##—(CH2)2—(O(CH2)2)4—(O(CH2)3)4—, ##—(CH2)2—(O(CH2)2)5—(O(CH2)3)5—, ##—(CH2)2—(O(CH2)2)6—(O(CH2)3)6—, ##—(CH2)3—O—(CH2)2—O—(CH2)3—, ##—(CH2)3—(O(CH2)2)2—(O(CH2)3)2—, ##—(CH2)3—(O(CH2)2)3—(O(CH2)3)3—, ##—(CH2)3—(O(CH2)2)4—(O(CH2)3)4—, ##—(CH2)3—(O(CH2)2)5—(O(CH2)3)5—, ##—(CH2)3—(O(CH2)2)6—(O(CH2)3)6—, ##—CH2—O—(CH2)3—O—(CH2)2—, ##—CH2—(O(CH2)3)2—(O(CH2)2)2—, ##—CH2—(O(CH2)3)3—(O(CH2)2)3—, ##—CH2—(O(CH2)3)4—(O(CH2)2)4—, ##—CH2—(O(CH2)3)5—(O(CH2)2)5—, ##—CH2—(O(CH2)3)6—(O(CH2)2)6—, ##—(CH2)2—O—(CH2)3—O—(CH2)2—, ##—(CH2)2—(O(CH2)3)2—(O(CH2)2)2—, ##—(CH2)2—(O(CH2)3)3—(O(CH2)2)3—, ##—(CH2)2—(O(CH2)3)4—(O(CH2)2)4—, ##—(CH2)2—(O(CH2)3)5—(O(CH2)2)5—, ##—(CH2)2—(O(CH2)3)6—(O(CH2)2)6—, ##—(CH2)3—O—(CH2)3—O—(CH2)2—, ##—(CH2)3—(O(CH2)3)2—(O(CH2)2)2—, ##—(CH2)3—(O(CH2)3)3—(O(CH2)2)3—, ##—(CH2)3—(O(CH2)3)4—(O(CH2)2)4—, ##—(CH2)3—(O(CH2)3)5—(O(CH2)2)5—, ##—(CH2)3—(O(CH2)3)6—(O(CH2)2)6—, ##—CH2—O—(CH2)2O—CH2—, ##—(CH2)2—O—(CH2)2O—CH2—, ##—(CH2)2—(O(CH2)2)2—O—(CH2)3—, ##—(CH2)2—(O(CH2)2)3—O—(CH2)3—, ##—(CH2)2—(O(CH2)2)4—O—(CH2)3—, ##—(CH2)5—(O(CH2)2)2—O—(CH2)5—, ##—(CH2)5—(O(CH2)2)2—O—(CH2)6—, ##—CH2—C(O)—CH2—, ##—CH2—C(O)—(CH2)2—, ##—(CH2)1—C(O)—(CH2)3—, ##—(CH2)1—C(O)—(CH2)4—, ##—(CH2)1—C(O)—(CH2)5—, ##—(CH2)1—C(O)—(CH2)6—, ##—(CH2)1—C(O)—(CH2)7—, ##—(CH2)1—C(O)—(CH2)8—, ##—(CH2)1—C(O)—(CH2)9—, ##—(CH2)1—C(O)—(CH2)10—, ##—(CH2)2—C(O)—(CH2)1—, ##—(CH2)2—C(O)—(CH2)2—, ##—(CH2)2—C(O)—(CH2)3—, ##—(CH2)2—C(O)—(CH2)4—, ##—(CH2)2—C(O)—(CH2)5—, ##—(CH2)2—C(O)—(CH2)6—, ##—(CH2)2—C(O)—(CH2)7—, ##—(CH2)2—C(O)—(CH2)8—, ##—(CH2)2—C(O)—(CH2)9—, ##—(CH2)2—C(O)—(CH2)10—, ##—(CH2)2—C(O)—(CH2)11—, ##—(CH2)2—C(O)—(CH2)12—, ##—(CH2)3—C(O)—(CH2)1—, ##—(CH2)3—C(O)—(CH2)2—, ##—(CH2)3—C(O)—(CH2)3—, ##—(CH2)3—C(O)—(CH2)4—, ##—(CH2)3—C(O)—(CH2)5—, ##—(CH2)3—C(O)—(CH2)6—, ##—(CH2)3—C(O)—(CH2)7—, ##—(CH2)4—C(O)—(CH2)1—, ##—(CH2)4—C(O)—(CH2)2—, ##—(CH2)4—C(O)—(CH2)3—, ##—(CH2)4—C(O)—(CH2)4—, ##—(CH2)4—C(O)—(CH2)5—, ##—(CH2)4—C(O)—(CH2)6—, ##—(CH2)5—C(O)—(CH2)1—, ##—(CH2)5—C(O)—(CH2)2—, ##—(CH2)5—C(O)—(CH2)3—, ##—(CH2)5—C(O)—(CH2)4—, ##—(CH2)5—C(O)—(CH2)5—, ##—(CH2)6—C(O)—(CH2)1—, ##—(CH2)6—C(O)—(CH2)2—, ##—(CH2)6—C(O)—(CH2)3—, ##—(CH2)6—C(O)—(CH2)4—, ##—(CH2)7—C(O)—(CH2)1—, ##—(CH2)7—C(O)—(CH2)2—, ##—(CH2)7—C(O)—(CH2)3—, ##—(CH2)8—C(O)—(CH2)1—, ##—(CH2)8—C(O)—(CH2)2—, ##—CH2—S—CH2—, ##—CH2—S—(CH2)2—, ##—(CH2)1—S—(CH2)3—, ##—(CH2)1—S—(CH2)4—, ##—(CH2)1—S—(CH2)5—, ##—(CH2)1—S—(CH2)6—, ##—(CH2)1—S—(CH2)7—, ##—(CH2)1—S—(CH2)8—, ##—(CH2)1—S—(CH2)9—, ##—(CH2)1—S—(CH2)10—, ##—(CH2)2—S—(CH2)1—, ##—(CH2)2—S—(CH2)2—, ##—(CH2)2—S—(CH2)3—, ##—(CH2)2—S—(CH2)4—, ##—(CH2)2—S—(CH2)5—, ##—(CH2)2—S—(CH2)6—, ##—(CH2)2—S—(CH2)7—, ##—(CH2)2—S—(CH2)8—, ##—(CH2)2—S—(CH2)9—, ##—(CH2)2—S—(CH2)10—, ##—(CH2)2—S—(CH2)11—, ##—(CH2)2—S—(CH2)12—, ##—(CH2)3—S—(CH2)1—, ##—(CH2)3—S—(CH2)2—, ##—(CH2)3—S—(CH2)3—, ##—(CH2)3—S—(CH2)4—, ##—(CH2)3—S—(CH2)5—, ##—(CH2)3—S—(CH2)6—, ##—(CH2)3—S—(CH2)7—, ##—(CH2)4—S—(CH2)1—, ##—(CH2)4—S—(CH2)2—, ##—(CH2)4—S—(CH2)3—, ##—(CH2)4—S—(CH2)4—, ##—(CH2)4—S—(CH2)5—, ##—(CH2)4—S—(CH2)6—, ##—(CH2)5—S—(CH2)1—, ##—(CH2)5—S—(CH2)2—, ##—(CH2)5—S—(CH2)3—, ##—(CH2)5—S—(CH2)4—, ##—(CH2)5—S—(CH2)5—, ##—(CH2)6—S—(CH2)1—, ##—(CH2)6—S—(CH2)2—, ##—(CH2)6—S—(CH2)3—, ##—(CH2)6—S—(CH2)4—, ##—(CH2)7—S—(CH2)1—, ##—(CH2)7—S—(CH2)2—, ##—(CH2)7—S—(CH2)3—, ##—(CH2)8—S—(CH2)1—, ##—(CH2)8—S—(CH2)2—, ##—CH2—C(S)—CH2—, ##—CH2—C(S)—(CH2)2—, ##—(CH2)1—C(S)—(CH2)3—, ##—(CH2)1—C(S)—(CH2)4—, ##—(CH2)1—C(S)—(CH2)5—, ##—(CH2)1—C(S)—(CH2)6—, ##—(CH2)1—C(S)—(CH2)7—, ##—(CH2)1—C(S)—(CH2)8—, ##—(CH2)1—C(S)—(CH2)9—, ##—(CH2)1—C(S)—(CH2)10—, ##—(CH2)2—C(S)—(CH2)1—, ##—(CH2)2—C(S)—(CH2)2—, ##—(CH2)2—C(S)—(CH2)3—, ##—(CH2)2—C(S)—(CH2)4—, ##—(CH2)2—C(S)—(CH2)5—, ##—(CH2)2—C(S)—(CH2)6—, ##—(CH2)2—C(S)—(CH2)7—, ##—(CH2)2—C(S)—(CH2)8—, ##—(CH2)2—C(S)—(CH2)9—, ##—(CH2)2—C(S)—(CH2)10—, ##—(CH2)2—C(S)—(CH2)11—, ##—(CH2)2—C(S)—(CH2)12—, ##—(CH2)3—C(S)—(CH2)1—, ##—(CH2)3—C(S)—(CH2)2—, ##—(CH2)3—C(S)—(CH2)3—, ##—(CH2)3—C(S)—(CH2)4—, ##—(CH2)3—C(S)—(CH2)5—, ##—(CH2)3—C(S)—(CH2)6—, ##—(CH2)3—C(S)—(CH2)7—, ##—(CH2)4—C(S)—(CH2)1—, ##—(CH2)4—C(S)—(CH2)2—, ##—(CH2)4—C(S)—(CH2)3—, ##—(CH2)4—C(S)—(CH2)4—, ##—(CH2)4—C(S)—(CH2)5—, ##—(CH2)4—C(S)—(CH2)6—, ##—(CH2)5—C(S)—(CH2)1—, ##—(CH2)5—C(S)—(CH2)2—, ##—(CH2)5—C(S)—(CH2)3—, ##—(CH2)5—C(S)—(CH2)4—, ##—(CH2)5—C(S)—(CH2)5—, ##—(CH2)6—C(S)—(CH2)1—, ##—(CH2)6—C(S)—(CH2)2—, ##—(CH2)6—C(S)—(CH2)3—, ##—(CH2)6—C(S)—(CH2)4—, ##—(CH2)7—C(S)—(CH2)1—, ##—(CH2)7—C(S)—(CH2)2—, ##—(CH2)7—C(S)—(CH2)3—, ##—(CH2)8—C(S)—(CH2)1—, ##—(CH2)8—C(S)—(CH2)2—, ##—CH2—C(O)O—CH2—, ##—CH2—C(O)O—(CH2)2—, ##—(CH2)1—C(O)O—(CH2)3—, ##—(CH2)1—C(O)O—(CH2)4—, ##—(CH2)1—C(O)O—(CH2)5—, ##—(CH2)1—C(O)O—(CH2)6—, ##—(CH2)1—C(O)O—(CH2)7—, ##—(CH2)1—C(O)O—(CH2)8—, ##—(CH2)1—C(O)O—(CH2)9—, ##—(CH2)1—C(O)O—(CH2)10—, ##—(CH2)2—C(O)O—(CH2)1—, ##—(CH2)2—C(O)O—(CH2)2—, ##—(CH2)2—C(O)O—(CH2)3—, ##—(CH2)2—C(O)O—(CH2)4—, ##—(CH2)2—C(O)O—(CH2)5—, ##—(CH2)2—C(O)O—(CH2)6—, ##—(CH2)2—C(O)O—(CH2)7—, ##—(CH2)2—C(O)O—(CH2)8—, ##—(CH2)2—C(O)O—(CH2)9—, ##—(CH2)2—C(O)O—(CH2)10—, ##—(CH2)2—C(O)O—(CH2)11—, ##—(CH2)2—C(O)O—(CH2)12—, ##—(CH2)3—C(O)O—(CH2)1—, ##—(CH2)3—C(O)O—(CH2)2—, ##—(CH2)3—C(O)O—(CH2)3—, ##—(CH2)3—C(O)O—(CH2)4—, ##—(CH2)3—C(O)O—(CH2)5—, ##—(CH2)3—C(O)O—(CH2)6—, ##—(CH2)3—C(O)O—(CH2)7—, ##—(CH2)4—C(O)O—(CH2)1—, ##—(CH2)4—C(O)O—(CH2)2—, ##—(CH2)4—C(O)O—(CH2)3—, ##—(CH2)4—C(O)O—(CH2)4—, ##—(CH2)4—C(O)O—(CH2)5—, ##—(CH2)4—C(O)O—(CH2)6—, ##—(CH2)5—C(O)O—(CH2)1—, ##—(CH2)5—C(O)O—(CH2)2—, ##—(CH2)5—C(O)O—(CH2)3—, ##—(CH2)5—C(O)O—(CH2)4—, ##—(CH2)5—C(O)O—(CH2)5—, ##—(CH2)6—C(O)O—(CH2)1—, ##—(CH2)6—C(O)O—(CH2)2—, ##—(CH2)6—C(O)O—(CH2)3—, ##—(CH2)6—C(O)O—(CH2)4—, ##—(CH2)7—C(O)O—(CH2)1—, ##—(CH2)7—C(O)O—(CH2)2—, ##—(CH2)7—C(O)O—(CH2)3—, ##—(CH2)8—C(O)O—(CH2)1—, ##—(CH2)8—C(O)O—(CH2)2—, ##—CH2—OC(O)—CH2—, ##—CH2—OC(O)—(CH2)2—, ##—(CH2)1—OC(O)—(CH2)3—, ##—(CH2)1—OC(O)—(CH2)4—, ##—(CH2)1—OC(O)—(CH2)5—, ##—(CH2)1—OC(O)—(CH2)6—, ##—(CH2)1—OC(O)—(CH2)7—, ##—(CH2)1—OC(O)—(CH2)8—, ##—(CH2)1—OC(O)—(CH2)9—, ##—(CH2)1—OC(O)—(CH2)10—, ##—(CH2)2—OC(O)—(CH2)1—, ##—(CH2)2—OC(O)—(CH2)2—, ##—(CH2)2—OC(O)—(CH2)3—, ##—(CH2)2—OC(O)—(CH2)4—, ##—(CH2)2—OC(O)—(CH2)5—, ##—(CH2)2—OC(O)—(CH2)6—, ##—(CH2)2—OC(O)—(CH2)7—, ##—(CH2)2—OC(O)—(CH2)8—, ##—(CH2)2—OC(O)—(CH2)9—, ##—(CH2)2—OC(O)—(CH2)10—, ##—(CH2)2—OC(O)—(CH2)11—, ##—(CH2)2—OC(O)—(CH2)12—, ##—(CH2)3—OC(O)—(CH2)1—, ##—(CH2)3—OC(O)—(CH2)2—, ##—(CH2)3—OC(O)—(CH2)3—, ##—(CH2)3—OC(O)—(CH2)4—, ##—(CH2)3—OC(O)—(CH2)5—, ##—(CH2)3—OC(O)—(CH2)6—, ##—(CH2)3—OC(O)—(CH2)7—, ##—(CH2)4—OC(O)—(CH2)1—, ##—(CH2)4—OC(O)—(CH2)2—, ##—(CH2)4—OC(O)—(CH2)3—, ##—(CH2)4—OC(O)—(CH2)4—, ##—(CH2)4—OC(O)—(CH2)5—, ##—(CH2)4—OC(O)—(CH2)6—, ##—(CH2)5—OC(O)—(CH2)1—, ##—(CH2)5—OC(O)—(CH2)2—, ##—(CH2)5—OC(O)—(CH2)3—, ##—(CH2)5—OC(O)—(CH2)4—, ##—(CH2)5—OC(O)—(CH2)5—, ##—(CH2)6—OC(O)—(CH2)1—, ##—(CH2)6—OC(O)—(CH2)2—, ##—(CH2)6—OC(O)—(CH2)3—, ##—(CH2)6—OC(O)—(CH2)4—, ##—(CH2)7—OC(O)—(CH2)1—, ##—(CH2)7—OC(O)—(CH2)2—, ##—(CH2)7—OC(O)—(CH2)3—, ##—(CH2)8—OC(O)—(CH2)1—, ##—(CH2)8—OC(O)—(CH2)2—, ##—(CH2)1—N(Rg10)—(CH2)1—, ##—(CH2)1—N(Rg10)—(CH2)2—, ##—(CH2)1—N(Rg10)—(CH2)3—, ##—(CH2)1—N(Rg10)—(CH2)4—, ##—(CH2)1—N(Rg10)—(CH2)5—, ##—(CH2)1—N(Rg10)—(CH2)6—, ##—(CH2)1—N(Rg10)—(CH2)7—, ##—(CH2)1—N(Rg10)—(CH2)8—, ##—(CH2)1—N(Rg10)—(CH2)9—, ##—(CH2)1—N(Rg10)—(CH2)10—, ##—(CH2)2—N(Rg10)—(CH2)1—, ##—(CH2)2—N(Rg10)—(CH2)2—, ##—(CH2)2—N(Rg10)—(CH2)3—, ##—(CH2)2—N(Rg10)—(CH2)4—, ##—(CH2)2—N(Rg10)—(CH2)5—, ##—(CH2)2—N(Rg10)—(CH2)6—, ##—(CH2)2—N(Rg10)—(CH2)7—, ##—(CH2)2—N(Rg10)—(CH2)8—, ##—(CH2)2—N(Rg10)—(CH2)9—, ##—(CH2)2—N(Rg10)—(CH2)10—, ##—(CH2)2—N(Rg10)—(CH2)11—, ##—(CH2)2—N(Rg10)—(CH2)12—, ##—(CH2)3—N(Rg10)—(CH2)1—, ##—(CH2)3—N(Rg10)—(CH2)2—, ##—(CH2)3—N(Rg10)—(CH2)3—, ##—(CH2)4—N(Rg10)—(CH2)1—, ##—(CH2)4—N(Rg10)—(CH2)2—, ##—(CH2)4—N(Rg10)—(CH2)3—, ##—(CH2)4—N(Rg10)—(CH2)4—, ##—(CH2)5—N(Rg10)—(CH2)1—, ##—(CH2)5—N(Rg10)—(CH2)2—, ##—(CH2)5—N(Rg10)—(CH2)3—, ##—(CH2)5—N(Rg10)—(CH2)4—, ##—(CH2)5—N(Rg10)—(CH2)5—, ##—(CH2)6—N(Rg10)—(CH2)1—, ##—(CH2)6—N(Rg10)—(CH2)2—, ##—(CH2)6—N(Rg10)—(CH2)3—, ##—(CH2)7—N(Rg10)—(CH2)1—, ##—(CH2)—N(Rg10)—(CH2)2—, ##—(CH2)7—N(Rg10)—(CH2)3—, ##—(CH2)8—N(Rg10)—(CH2)1—, ##—(CH2)8—N(Rg10)—(CH2)2—, ##—(CH2)8—N(Rg10)—(CH2)3—, ##—CH(CH3)—N(Rg10)—(CH2)1—, ##—CH(CH3)—N(Rg10)—(CH2)2—, ##—CH(CH3)—N(Rg10)—(CH2)3—, ##—CH(CH3)—N(Rg10)—(CH2)4—, ##—CH(CH3)—N(Rg10)—(CH2)5—, ##—CH(CH3)—N(Rg10)—(CH2)8—, ##—CH(CH3)—N(Rg10)—(CH2)—, ##—CH(CH3)—N(Rg10)—(CH2)8—, ##—CH(CH3)—N(Rg10)—(CH2)9—, ##—CH(CH3)—N(Rg10)—(CH2)10—, ##—CH2C(O)NHCH2—, ##—(CH2)2C(O)NH(CH2)2—, ##—(CH2)2C(O)NH(CH2)3—, ##—(CH2)2C(O)NH(CH2)4—, ##—(CH2)2C(O)NH(CH2)5—, ##—(CH2)3C(O)NH(CH2)3—, ##—(CH2)3C(O)NH(CH2)4—, ##—(CH2)4C(O)NH(CH2)4—, ##—(CH2)5C(O)NH(CH2)5—, ##—(CH2)6C(O)NH(CH2)7—, ##—(CH2)6C(O)NH(CH2)6—, ##—(CH2)7C(O)NH(CH2)7—, ##—(CH2)8C(O)NH(CH2)8, ##—(CH2)9C(O)NH(CH2)9—, ##—(CH2)10C(O)NH(CH2)10—, ##—(CH2)2C(O)NH(CH2)2—O—(CH2)2—, ##—CH2NHC(O)CH2—, ##—(CH2)2NHC(O)(CH2)2—, ##—(CH2)2NHC(O)(CH2)3—, ##—(CH2)2NHC(O)(CH2)4—, ##—(CH2)2NHC(O)(CH2)5—, ##—(CH2)3NHC(O)(CH2)3—, ##—(CH2)3NHC(O)(CH2)4—, ##—(CH2)4NHC(O)(CH2)4—, ##—(CH2)5NHC(O)(CH2)5—, ##—(CH2)6NHC(O)(CH2)7—, ##—(CH2)6NHC(O)(CH2)6—, ##—(CH2)7NHC(O)(CH2)7—, ##—(CH2)8NHC(O)(CH2)8, ##—(CH2)9NHC(O)(CH2)9—, ##—(CH2)10NHC(O)(CH2)10—, ##—(CH2)4NHC(O)(CH2)5—, ##—(CH2)2NHC(O)(CH2)2—O—(CH2)2—, ##—(CH2)4NHC(O)CH2—, ##—CH2-piperidinylene-CH2—, ##—CH2-piperidinylene-(CH2)2—, ##—CH2-piperidinylene-(CH2)3—, ##—CH2-piperidinylene-(CH2)4—, ##—CH2-piperidinylene-(CH2)5—, ##—CH2-piperidinylene-(CH2)6—, ##—CH2-piperidinylene-(CH2)7—, ##—CH2-piperidinylene-(CH2)8—, ##—(CH2)2-piperidinylene-(CH2)1—, ##—(CH2)2-piperidinylene-(CH2)2—, ##—(CH2)2-piperidinylene-(CH2)3—, ##—(CH2)2-piperidinylene-(CH2)4—, ##—(CH2)2-piperidinylene-(CH2)5—, ##—(CH2)2-piperidinylene-(CH2)6—, ##—(CH2)2-piperidinylene-(CH2)7—, ##—(CH2)2-piperidinylene-(CH2)8—, ##—(CH2)3-piperidinylene-CH2—, ##—(CH2)3-piperidinylene-(CH2)2—, ##—(CH2)3-piperidinylene-(CH2)3—, ##—(CH2)3-piperidinylene-(CH2)4—, ##—(CH2)3-piperidinylene-(CH2)5—, ##—(CH2)3-piperidinylene-(CH2)6—, ##—(CH2)3-piperidinylene-(CH2)7—, ##—(CH2)3-piperidinylene-(CH2)8—, ##—(CH2)4-piperidinylene-CH2—, ##—(CH2)4-piperidinylene-(CH2)2—, ##—(CH2)4-piperidinylene-(CH2)3—, ##—(CH2)4-piperidinylene-(CH2)4—, ##—(CH2)4-piperidinylene-(CH2)5—, ##—(CH2)4-piperidinylene-(CH2)6—, ##—(CH2)4-piperidinylene-(CH2)7—, ##—(CH2)4-piperidinylene-(CH2)8—, ##—(CH2)5-piperidinylene-(CH2)1—, ##—(CH2)5-piperidinylene-(CH2)2—, ##—(CH2)5-piperidinylene-(CH2)3—, ##—(CH2)5-piperidinylene-(CH2)4—, ##—(CH2)5-piperidinylene-(CH2)5—, ##—(CH2)5-piperidinylene-(CH2)6—, ##—(CH2)5-piperidinylene-(CH2)7—, ##—(CH2)5-piperidinylene-(CH2)8—, ##—(CH2)6-piperidinylene-(CH2)1—, ##—(CH2)6-piperidinylene-(CH2)2—, ##—(CH2)6-piperidinylene-(CH2)3—, ##—(CH2)6-piperidinylene-(CH2)4—, ##—(CH2)6-piperidinylene-(CH2)5—, ##—(CH2)6-piperidinylene-(CH2)6—, ##—(CH2)6-piperidinylene-(CH2)7—, ##—(CH2)6-piperidinylene-(CH2)8—, ##—(CH2)7-piperidinylene-(CH2)1—, ##—(CH2)7-piperidinylene-(CH2)2—, ##—(CH2)7-piperidinylene-(CH2)3—, ##—(CH2)7-piperidinylene-(CH2)4—, ##—(CH2)7-piperidinylene-(CH2)8—, ##—(CH2)5-piperidinylene-CH2—, ##—(CH2)5-piperidinylene-(CH2)2—, ##—(CH2)5-piperidinylene-(CH2)3—, ##—(CH2)5-piperidinylene-(CH2)4—, ##—(CH2)5-piperidinylene-(CH2)5—, ##—(CH2)5-piperidinylene-(CH2)6—, ##—(CH2)5-piperidinylene-(CH2)7—, ##—(CH2)5-piperidinylene-(CH2)8—, ##—CH2-piperazinylene-CH2—, ##—CH2-piperazinylene-(CH2)2—, ##—CH2-piperazinylene-(CH2)3—, ##—CH2-piperazinylene-(CH2)4—, ##—CH2-piperazinylene-(CH2)5—, ##—CH2-piperazinylene-(CH2)6—, ##—CH2-piperazinylene-(CH2)7—, ##—CH2-piperazinylene-(CH2)8—, ##—(CH2)2-piperazinylene-(CH2)1—, ##—(CH2)2-piperazinylene-(CH2)2—, ##—(CH2)2-piperazinylene-(CH2)3—, ##—(CH2)2-piperazinylene-(CH2)4—, ##—(CH2)2-piperazinylene-(CH2)5—, ##—(CH2)2-piperazinylene-(CH2)6—, ##—(CH2)2-piperazinylene-(CH2)7—, ##—(CH2)2-piperazinylene-(CH2)8—, ##—(CH2)3-piperazinylene-CH2—, ##—(CH2)3-piperazinylene-(CH2)2—, ##—(CH2)3-piperazinylene-(CH2)3—, ##—(CH2)3-piperazinylene-(CH2)4—, ##—(CH2)3-piperazinylene-(CH2)5—, ##—(CH2)3-piperazinylene-(CH2)6—, ##—(CH2)3-piperazinylene-(CH2)7—, ##—(CH2)3-piperazinylene-(CH2)8—, ##—(CH2)4-piperazinylene-CH2—, ##—(CH2)4-piperazinylene-(CH2)2—, ##—(CH2)4-piperazinylene-(CH2)3—, ##—(CH2)4-piperazinylene-(CH2)4—, ##—(CH2)4-piperazinylene-(CH2)5—, ##—(CH2)4-piperazinylene-(CH2)6—, ##—(CH2)4-piperazinylene-(CH2)7—, ##—(CH2)4-piperazinylene-(CH2)8—, ##—(CH2)5-piperazinylene-(CH2)1—, ##—(CH2)5-piperazinylene-(CH2)2—, ##—(CH2)5-piperazinylene-(CH2)3—, ##—(CH2)5-piperazinylene-(CH2)4—, ##—(CH2)5-piperazinylene-(CH2)5—, ##—(CH2)5-piperazinylene-(CH2)6—, ##—(CH2)5-piperazinylene-(CH2)7—, ##—(CH2)5-piperazinylene-(CH2)8—, ##—(CH2)6-piperazinylene-(CH2)1—, ##—(CH2)6-piperazinylene-(CH2)2—, ##—(CH2)6-piperazinylene-(CH2)3—, ##—(CH2)6-piperazinylene-(CH2)4—, ##—(CH2)6-piperazinylene-(CH2)5—, ##—(CH2)6-piperazinylene-(CH2)6—, ##—(CH2)6-piperazinylene-(CH2)7—, ##—(CH2)6-piperazinylene-(CH2)8—, ##—(CH2)7-piperazinylene-(CH2)1—, ##—(CH2)7-piperazinylene-(CH2)2—, ##—(CH2)7-piperazinylene-(CH2)3—, ##—(CH2)7-piperazinylene-(CH2)4—, ##—(CH2)7-piperazinylene-(CH2)8—, ##—(CH2)8-piperazinylene-CH2—, ##—(CH2)8-piperazinylene-(CH2)2—, ##—(CH2)8-piperazinylene-(CH2)3—, ##—(CH2)8-piperazinylene-(CH2)4—, ##—(CH2)8-piperazinylene-(CH2)5—, ##—(CH2)8-piperazinylene-(CH2)6—, ##—(CH2)8-piperazinylene-(CH2)7—, ##—(CH2)8-piperazinylene-(CH2)8—, ##—CH2-propylene-CH2—, ##—CH2-propylene-(CH2)2—, ##—CH2-propylene-(CH2)3—, ##—CH2-propylene-(CH2)4—, ##—CH2-propylene-(CH2)5—, ##—CH2-propylene-(CH2)6—, ##—CH2-propylene-(CH2)7—, ##—CH2-propylene-(CH2)8—, ##—(CH2)2-propylene-(CH2)1—, ##—(CH2)2-propylene-(CH2)2—, ##—(CH2)2-propylene-(CH2)3—, ##—(CH2)2-propylene-(CH2)4—, ##—(CH2)2-propylene-(CH2)5—, ##—(CH2)2-propylene-(CH2)6—, ##—(CH2)2-propylene-(CH2)7—, ##—(CH2)2-propylene-(CH2)8—, ##—(CH2)3-propylene-CH2—, ##—(CH2)3-propylene-(CH2)2—, ##—(CH2)3-propylene-(CH2)3—, ##—(CH2)3-propylene-(CH2)4—, ##—(CH2)3-propylene-(CH2)5—, ##—(CH2)3-propylene-(CH2)6—, ##—(CH2)3-propylene-(CH2)7—, ##—(CH2)3-propylene-(CH2)8—, ##—(CH2)4-propylene-CH2—, ##—(CH2)4-propylene-(CH2)2—, ##—(CH2)4-propylene-(CH2)3—, ##—(CH2)4-propylene-(CH2)4—, ##—(CH2)4-propylene-(CH2)5—, ##—(CH2)4-propylene-(CH2)6—, ##—(CH2)4-propylene-(CH2)7—, ##—(CH2)4-propylene-(CH2)8—, ##—(CH2)5-propylene-(CH2)1—, ##—(CH2)5-propylene-(CH2)2—, ##—(CH2)5-propylene-(CH2)3—, ##—(CH2)5-propylene-(CH2)4—, ##—(CH2)5-propylene-(CH2)5—, ##—(CH2)5-propylene-(CH2)6—, ##—(CH2)5-propylene-(CH2)7—, ##—(CH2)5-propylene-(CH2)8—, ##—(CH2)6-propylene-(CH2)1—, ##—(CH2)6-propylene-(CH2)2—, ##—(CH2)6-propylene-(CH2)3—, ##—(CH2)6-propylene-(CH2)4—, ##—(CH2)6-propylene-(CH2)5—, ##—(CH2)6-propylene-(CH2)6—, ##—(CH2)6-propylene-(CH2)7—, ##—(CH2)6-propylene-(CH2)8—, ##—(CH2)7-propylene-(CH2)1—, ##—(CH2)7-propylene-(CH2)2—, ##—(CH2)7-propylene-(CH2)3—, ##—(CH2)7-propylene-(CH2)4—, ##—(CH2)7-propylene-(CH2)8—, ##—(CH2)8-propylene-CH2—, ##—(CH2)8-propylene-(CH2)2—, ##—(CH2)8-propylene-(CH2)3—, ##—(CH2)8-propylene-(CH2)4—, ##—(CH2)8-propylene-(CH2)5—, ##—(CH2)8-propylene-(CH2)6—, ##—(CH2)8-propylene-(CH2)7—, ##—(CH2)8-propylene-(CH2)8—, ##—CH2-diazacycloheptanylene-CH2—, ##—CH2-diazacycloheptanylene-(CH2)2—, ##—CH2-diazacycloheptanylene-(CH2)3—, ##—CH2-diazacycloheptanylene-(CH2)4—, ##—CH2-diazacycloheptanylene-(CH2)5—, ##—CH2-diazacycloheptanylene-(CH2)6—, ##—CH2-diazacycloheptanylene-(CH2)7—, ##—CH2-diazacycloheptanylene-(CH2)8—, ##—(CH2)2-diazacycloheptanylene-(CH2)1—, ##—(CH2)2-diazacycloheptanylene-(CH2)2—, ##—(CH2)2-diazacycloheptanylene-(CH2)3—, ##—(CH2)2-diazacycloheptanylene-(CH2)4—, ##—(CH2)2-diazacycloheptanylene-(CH2)5—, ##—(CH2)2-diazacycloheptanylene-(CH2)6—, ##—(CH2)2-diazacycloheptanylene-(CH2)7—, ##—(CH2)2-diazacycloheptanylene-(CH2)8—, ##—(CH2)3-diazacycloheptanylene-CH2—, ##—(CH2)3-diazacycloheptanylene-(CH2)2—, ##—(CH2)3-diazacycloheptanylene-(CH2)3—, ##—(CH2)3-diazacycloheptanylene-(CH2)4—, ##—(CH2)3-diazacycloheptanylene-(CH2)5—, ##—(CH2)3-diazacycloheptanylene-(CH2)6—, ##—(CH2)3-diazacycloheptanylene-(CH2)7—, ##—(CH2)3-diazacycloheptanylene-(CH2)8—, ##—(CH2)4-diazacycloheptanylene-CH2—, ##—(CH2)4-diazacycloheptanylene-(CH2)2—, ##—(CH2)4-diazacycloheptanylene-(CH2)3—, ##—(CH2)4-diazacycloheptanylene-(CH2)4—, ##—(CH2)4-diazacycloheptanylene-(CH2)5—, ##—(CH2)4-diazacycloheptanylene-(CH2)6—, ##—(CH2)4-diazacycloheptanylene-(CH2)7—, ##—(CH2)4-diazacycloheptanylene-(CH2)8—, ##—(CH2)8-diazacycloheptanylene-(CH2)1—, ##—(CH2)5-diazacycloheptanylene-(CH2)2—, ##—(CH2)5-diazacycloheptanylene-(CH2)3—, ##—(CH2)5-diazacycloheptanylene-(CH2)4—, ##—(CH2)5-diazacycloheptanylene-(CH2)5—, ##—(CH2)5-diazacycloheptanylene-(CH2)6—, ##—(CH2)5-diazacycloheptanylene-(CH2)7—, ##—(CH2)5-diazacycloheptanylene-(CH2)8—, ##—(CH2)6-diazacycloheptanylene-(CH2)1—, ##—(CH2)6-diazacycloheptanylene-(CH2)2—, ##—(CH2)6-diazacycloheptanylene-(CH2)3—, ##—(CH2)6-diazacycloheptanylene-(CH2)4—, ##—(CH2)6-diazacycloheptanylene-(CH2)5—, ##—(CH2)6-diazacycloheptanylene-(CH2)6—, ##—(CH2)6-diazacycloheptanylene-(CH2)7—, ##—(CH2)6-diazacycloheptanylene-(CH2)8—, ##—(CH2)7-diazacycloheptanylene-(CH2)1—, ##—(CH2)7-diazacycloheptanylene-(CH2)2—, ##—(CH2)7-diazacycloheptanylene-(CH2)3—, ##—(CH2)7-diazacycloheptanylene-(CH2)4—, ##—(CH2)7-diazacycloheptanylene-(CH2)8—, ##—(CH2)8-diazacycloheptanylene-CH2—, ##—(CH2)8-diazacycloheptanylene-(CH2)2—, ##—(CH2)8-diazacycloheptanylene-(CH2)3—, ##—(CH2)8-diazacycloheptanylene-(CH2)4—, ##—(CH2)8-diazacycloheptanylene-(CH2)5—, ##—(CH2)8-diazacycloheptanylene-(CH2)6—, ##—(CH2)8-diazacycloheptanylene-(CH2)7—, ##—(CH2)8-diazacycloheptanylene-(CH2)8—, ##—CH2-diazabicyclo[2.2.1]heptanylene-CH2—, ##—CH2-diazabicyclo[2.2.1]heptanylene-(CH2)2—, ##—CH2-diazabicyclo[2.2.1]heptanylene-(CH2)3—, ##—CH2-diazabicyclo[2.2.1]heptanylene-(CH2)4—, ##—CH2-diazabicyclo[2.2.1]heptanylene-(CH2)5—, ##—CH2-diazabicyclo[2.2.1]heptanylene-(CH2)6—, ##—CH2-diazabicyclo[2.2.1]heptanylene-(CH2)7—, ##—CH2-diazabicyclo[2.2.1]heptanylene-(CH2)8—, ##—(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)1—, ##—(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)2—, ##—(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)3—, ##—(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)4—, ##—(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)5—, ##—(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)6—, ##—(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)7—, ##—(CH2)2-diazabicyclo[2.2.1]heptanylene-(CH2)5—, ##—(CH2)3-diazabicyclo[2.2.1]heptanylene-CH2—, ##—(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)2—, ##—(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)3—, ##—(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)4—, ##—(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)5—, ##—(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)6—, ##—(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)7—, ##—(CH2)3-diazabicyclo[2.2.1]heptanylene-(CH2)8—, ##—(CH2)4-diazabicyclo[2.2.1]heptanylene-CH2—, ##—(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)2—, ##—(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)3—, ##—(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)4—, ##—(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)5—, ##—(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)6—, ##—(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)7—, ##—(CH2)4-diazabicyclo[2.2.1]heptanylene-(CH2)5—, ##—(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)1—, ##—(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)2—, ##—(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)3—, ##—(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)4—, ##—(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)5—, ##—(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)6—, ##—(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)7—, ##—(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)8—, ##—(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)1—, ##—(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)2—, ##—(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)3—, ##—(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)4—, ##—(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)5—, ##—(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)6—, ##—(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)7—, ##—(CH2)6-diazabicyclo[2.2.1]heptanylene-(CH2)8—, ##—(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)1—, ##—(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)2—, ##—(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)3—, ##—(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)4—, ##—(CH2)7-diazabicyclo[2.2.1]heptanylene-(CH2)8—, ##—(CH2)8-diazabicyclo[2.2.1]heptanylene-CH2—, ##—(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)2—, ##—(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)3—, ##—(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)4—, ##—(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)5—, ##—(CH2)5-diazabicyclo[2.2.1]heptanylene-(CH2)6—, ##—(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)7—, ##—(CH2)8-diazabicyclo[2.2.1]heptanylene-(CH2)8—, ##—CH2-diazabicyclo[3.1.1]heptanylene-CH2—, ##—CH2-diazabicyclo[3.1.1]heptanylene-(CH2)2—, ##—CH2-diazabicyclo[3.1.1]heptanylene-(CH2)3—, ##—CH2-diazabicyclo[3.1.1]heptanylene-(CH2)4—, ##—CH2-diazabicyclo[3.1.1]heptanylene-(CH2)5—, ##—CH2-diazabicyclo[3.1.1]heptanylene-(CH2)6—, ##—CH2-diazabicyclo[3.1.1]heptanylene-(CH2)7—, ##—CH2-diazabicyclo[3.1.1]heptanylene-(CH2)8—, ##—(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)1—, ##—(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)2—, ##—(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)3—, ##—(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)4—, ##—(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)5—, ##—(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)6—, ##—(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)7—, ##—(CH2)2-diazabicyclo[3.1.1]heptanylene-(CH2)8—, ##—(CH2)3-diazabicyclo[3.1.1]heptanylene-CH2—, ##—(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)2—, ##—(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)3—, ##—(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)4—, ##—(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)5—, ##—(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)6—, ##—(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)7—, ##—(CH2)3-diazabicyclo[3.1.1]heptanylene-(CH2)8—, ##—(CH2)4-diazabicyclo[3.1.1]heptanylene-CH2—, ##—(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)2—, ##—(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)3—, ##—(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)4—, ##—(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)5—, ##—(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)6—, ##—(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)7—, ##—(CH2)4-diazabicyclo[3.1.1]heptanylene-(CH2)8—, ##—(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)1—, ##—(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)2—, ##—(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)3—, ##—(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)4—, ##—(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)5—, ##—(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)6—, ##—(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)7—, ##—(CH2)5-diazabicyclo[3.1.1]heptanylene-(CH2)8—, ##—(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)1—, ##—(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)2—, ##—(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)3—, ##—(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)4—, ##—(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)5—, ##—(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)6—, ##—(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)7—, ##—(CH2)6-diazabicyclo[3.1.1]heptanylene-(CH2)8—, ##—(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)1—, ##—(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)2—, ##—(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)3—, ##—(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)4—, ##—(CH2)7-diazabicyclo[3.1.1]heptanylene-(CH2)8—, ##—(CH2)8-diazabicyclo[3.1.1]heptanylene-CH2—, ##—(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)2—, ##—(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)3—, ##—(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)4—, ##—(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)5—, ##—(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)6—, ##—(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)7—, ##—(CH2)8-diazabicyclo[3.1.1]heptanylene-(CH2)8—, ##—CH2-diazabicyclo[3.2.1]octylene-CH2—, ##—CH2-diazabicyclo[3.2.1]octylene-(CH2)2—, ##—CH2-diazabicyclo[3.2.1]octylene-(CH2)3—, ##—CH2-diazabicyclo[3.2.1]octylene-(CH2)4—, ##—CH2-diazabicyclo[3.2.1]octylene-(CH2)5—, ##—CH2-diazabicyclo[3.2.1]octylene-(CH2)6—, ##—CH2-diazabicyclo[3.2.1]octylene-(CH2)7—, ##—CH2-diazabicyclo[3.2.1]octylene-(CH2)8—, ##—(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)1—, ##—(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)2—, ##—(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)3—, ##—(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)4—, ##—(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)5—, ##—(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)6—, ##—(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)7—, ##—(CH2)2-diazabicyclo[3.2.1]octylene-(CH2)8—, ##—(CH2)3-diazabicyclo[3.2.1]octylene-CH2—, ##—(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)2—, ##—(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)3—, ##—(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)4—, ##—(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)5—, ##—(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)6—, ##—(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)7—, ##—(CH2)3-diazabicyclo[3.2.1]octylene-(CH2)8—, ##—(CH2)4-diazabicyclo[3.2.1]octylene-CH2—, ##—(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)2—, ##—(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)3—, ##—(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)4—, ##—(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)5—, ##—(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)6—, ##—(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)7—, ##—(CH2)4-diazabicyclo[3.2.1]octylene-(CH2)8—, ##—(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)1—, ##—(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)2—, ##—(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)3—, ##—(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)4—, ##—(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)5—, ##—(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)6—, ##—(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)7—, ##—(CH2)5-diazabicyclo[3.2.1]octylene-(CH2)8—, ##—(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)1—, ##—(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)2—, ##—(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)3—, ##—(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)4—, ##—(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)5—, ##—(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)6—, ##—(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)7—, ##—(CH2)6-diazabicyclo[3.2.1]octylene-(CH2)8—, ##—(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)1—, ##—(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)2—, ##—(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)3—, ##—(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)4—, ##—(CH2)7-diazabicyclo[3.2.1]octylene-(CH2)5—, ##—(CH2)8-diazabicyclo[3.2.1]octylene-CH2—, ##—(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)2—, ##—(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)3—, ##—(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)4—, ##—(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)5—, ##—(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)6—, ##—(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)7—, ##—(CH2)8-diazabicyclo[3.2.1]octylene-(CH2)8—, ##—CH2-diazabicyclo[2.2.2]octylene-CH2—, ##—CH2-diazabicyclo[2.2.2]octylene-(CH2)2—, ##—CH2-diazabicyclo[2.2.2]octylene-(CH2)3—, ##—CH2-diazabicyclo[2.2.2]octylene-(CH2)4—, ##—CH2-diazabicyclo[2.2.2]octylene-(CH2)5—, ##—CH2-diazabicyclo[2.2.2]octylene-(CH2)6—, ##—CH2-diazabicyclo[2.2.2]octylene-(CH2)7—, ##—CH2-diazabicyclo[2.2.2]octylene-(CH2)8—, ##—(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)1—, ##—(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)2—, ##—(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)3—, ##—(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)4—, ##—(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)5—, ##—(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)6—, ##—(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)7—, ##—(CH2)2-diazabicyclo[2.2.2]octylene-(CH2)8—, ##—(CH2)3-diazabicyclo[2.2.2]octylene-CH2—, ##—(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)2—, ##—(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)3—, ##—(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)4—, ##—(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)5—, ##—(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)6—, ##—(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)7—, ##—(CH2)3-diazabicyclo[2.2.2]octylene-(CH2)8—, ##—(CH2)4-diazabicyclo[2.2.2]octylene-CH2—, ##—(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)2—, ##—(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)3—, ##—(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)4—, ##—(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)5—, ##—(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)6—, ##—(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)7—, ##—(CH2)4-diazabicyclo[2.2.2]octylene-(CH2)8—, ##—(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)1—, ##—(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)2—, ##—(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)3—, ##—(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)4—, ##—(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)5—, ##—(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)6—, ##—(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)7—, ##—(CH2)5-diazabicyclo[2.2.2]octylene-(CH2)8—, ##—(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)1—, ##—(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)2—, ##—(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)3—, ##—(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)4—, ##—(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)5—, ##—(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)6—, ##—(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)7—, ##—(CH2)6-diazabicyclo[2.2.2]octylene-(CH2)8—, ##—(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)1—, ##—(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)2—, ##—(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)3—, ##—(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)4—, ##—(CH2)7-diazabicyclo[2.2.2]octylene-(CH2)8—, ##—(CH2)8-diazabicyclo[2.2.2]octylene-CH2—, ##—(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)2—, ##—(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)3—, ##—(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)4—, ##—(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)5—, ##—(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)6—, ##—(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)7—, or ##—(CH2)8-diazabicyclo[2.2.2]octylene-(CH2)8—; wherein the propylene, the piperidinylene, the piperazinylene, the diazacycloheptanylene, the diazabicyclo[2.2.1]heptanylene, the diazabicyclo[3.1.1]heptanylene, the diazabicyclo[3.2.1]octylene, the diazabicyclo[2.2.2]octylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH— or any combination thereof;each Rg10 independently represents H or C1-3 alkyl; andsymbol ## indicates the point of attachment to X1;preferably, wherein L1 represents the following group:

29. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein L1 represents the structure of the following formula: ##—C1-30 alkylene-, wherein a hydrogen atom of one or more CH2 groups of the C1-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X1; preferably, wherein L1 represents the following group:##—CH2—, ##—(CH2)2—, ##—(CH2)3—, ##—(CH2)4—, ##—(CH2)5—, ##—(CH2)2—CF2—(CH2)2—, ##—(CH2)6—, ##—(CH2)7—, ##—(CH2)8—, ##—(CH2)9—, ##—(CH2)10—, ##—(CH2)11—, ##—(CH2)12—, ##—(CH2)13—, ##—(CH2)14—, ##—(CH2)15—, ##—(CH2)16—, ##—(CH2)17—, ##—(CH2)18—, ##—(CH2)19—, ##—(CH2)20—, ##—(CH2)21—, ##—(CH2)22—, ##—(CH2)25—, or ##—(CH2)30—;wherein the hydrogen atom of one or more CH2 groups of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X1.

30. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 7, wherein L1 represents the structure of the following formula: ##—C4-30 alkylene-, wherein a hydrogen atom of one or more CH2 groups of the C4-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X1; preferably, wherein L1 represents the following group:##—(CH2)4—, ##—(CH2)5—, ##—(CH2)2—CF2—(CH2)2—, ##—(CH2)6—, ##—(CH2)7—, ##—(CH2)8—, ##—(CH2)9—, ##—(CH2)10—, ##—(CH2)11—, ##—(CH2)12—, ##—(CH2)13—, ##—(CH2)14—, ##—(CH2)15—, ##—(CH2)16—, ##—(CH2)17—, ##—(CH2)18—, ##—(CH2)19—, ##—(CH2)20—, ##—(CH2)21—, ##—(CH2)22—, ##—(CH2)25—, or ##—(CH2)30—;wherein the hydrogen atom of one or more CH2 groups of the group is optionally replaced with a substituent selected from the group consisting of: D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, halogenated C1-6 alkyl, optionally deuterated C3-6cycloalkyl, C1-6 alkoxy or any combination thereof, and symbol ## indicates the point of attachment to X1.

31. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Rb represents the following group: CH3, CF3, CD3, CH2CH3, —(CH2)2—CH3, —(CH2)3—CH3, —(CH2)4—CH3, —(CH2)5—CH3, —(CH2)6—CH3, —(CH2)7—CH3, —(CH2)8—CH3, —(CH2)9—CH3, —(CH2)10—CH3, —(CH2)11—CH3, —(CH2)12—CH3, —(CH2)13—CH3, —(CH2)14—CH3, —(CH2)15—CH3, —(CH2)16—CH3, —(CH2)17—CH3, —(CH2)18—CH3, —(CH2)19—CH3, —(CH2)20—CH3, —(CH2)21—CH3, —(CH2)22—CH3, —(CH2)23—CH3, —(CH2)24—CH3, —(CH2)25—CH3, —(CH2)26—CH3, —(CH2)27—CH3, —(CH2)28—CH3, or —(CH2)29—CH3.

32. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein L2 or L3 each independently represent the structure of the following formula: —C2-30 alkylene-, wherein a hydrogen atom of one or more CH2 groups of the C2-30 alkylene is optionally replaced with a substituent selected from the group consisting of: D, C1-4 alkyl, halogen, C3-6cycloalkyl or any combination thereof; or preferably, wherein L2 or L3 each independently represent the following group:—CH2—, —(CH2)2—, —(CH2)3—, —(CH2)4—, —(CH2)5—, —(CH2)2—CF2—(CH2)2—, —(CH2)6—, —(CH2)7—, —(CH2)8—, —(CH2)9—, —(CH2)10—, —(CH2)11—, —(CH2)12—, —(CH2)13—, —(CH2)14—, —(CH2)15—, —(CH2)16—, —(CH2)17—, —(CH2)18—, —(CH2)19—, —(CH2)20—, —(CH2)21—, —(CH2)22—, —(CH2)25—, or —(CH2)30;wherein the hydrogen atom of one or more CH2 groups of the group is optionally replaced with a substituent selected from the group consisting of: D, C1-4 alkyl, halogen, C3-6cycloalkyl or any combination thereof.

33. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein (i) L2 represents the structure of the following formula: —(C(Ra9)(Ra10))m1—(R12(C(Ra11)(Ra12))m2)p1—;—(C(Ra9)(Ra10))m1—(R12(C(Ra11)(Ra12))m2)p1—(R12(C(Ra13)(Ra14))m3)p2;—(C(Ra9)(Ra10))m1—(R12(C(Ra11)(Ra12))m2)p1—(R12(C(Ra13)(Ra14))m3)p2—(R12(C(Ra15)(Ra16))m4)p3—;—(C(Ra9)(Ra10))m1—(R13(C(Ra11)(Ra12))m2)p1—;—(C(Ra9)(Ra10))m1—(R13(C(Ra11)(Ra12))m2)p1—(R13(C(Ra13)(Ra14))m3)p2—;—(C(Ra9)(Ra10))m1—(R13(C(Ra11)(Ra12))m2)p1—(R13(C(Ra13)(Ra14))m3)p2—(R13(C(Ra15)(Ra16))m4)p3—;—(C(Ra9)(Ra10))m1—(R12—R13—(C(Ra11)(Ra12))m2)p1—;—(C(Ra9)(Ra10))m1—(R12(C(Ra11)(Ra12))m2)p1—(R13(C(Ra13)(Ra14))m3)p2—;—(C(Ra9)(Ra10))m1—(R13—R12—(C(Ra11)(Ra12))m2)p1—; or—(C(Ra9)(Ra10))m1—(R13(C(Ra11)(Ra12))m2)p1—(R12(C(Ra13)(Ra14))m3)p2—;wherein each R12 is independently selected from the group consisting of O, S, N(R14), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, wherein each R14 independently represents H or C1-3 alkyl; and each group R13 is independently selected from the group consisting of optionally substituted C3-15cycloalkylene, optionally substituted 4- to 15-membered heterocyclylene, optionally substituted C6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C2-6 alkenylene, C2-6 alkynylene or any combination thereof, wherein the C3-15cycloalkylene, the C6-10 arylene, the 4- to 15-membered heterocyclylene and the 5- to 15-membered heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-4 alkyl, optionally deuterated C3-6cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH— or any combination thereof, Ra9, Ra10, Ra11, Ra11, Ra13, Ra14, Ra15 and Ra16 each independently represent H, deuterium, halogen, C1-4 alkyl, C3-6cycloalkyl or any combination thereof; andm1, m2, m3, m4, p1, p2, p3 are each independently selected from the group consisting of an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15; and/or(ii) L3 represents the structure of the following formula: —(C(Ra9)(Ra10))m1—(R16(C(Ra11)(Ra12))m2)p1—;—(C(Ra9)(Ra10))m1—(R16(C(Ra11)(Ra12))m2)p1—(R16(C(Ra13)(Ra14))m3)p2—;—(C(Ra9)(Ra10))m1—(R16(C(Ra11)(Ra12))m2)p1—(R16(C(Ra13)(Ra14))m3)p2—(R16(C(Ra15)(Ra16))m4)p3—;—(C(Ra9)(Ra10))m1—(R17(C(Ra11)(Ra12))m2)p1—;—(C(Ra9)(Ra10))m1—(R17(C(Ra11)(Ra12))m2)p1—(R17(C(Ra13)(Ra14))m3)p2—;

34. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Rb1 represents: cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; orfuranyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;preferably, wherein Rb1 represents:

35. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, wherein Rb2 represents: cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, octahydropentalenyl, octahydro-1H-indenyl, spiro[3.3]heptanyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthanyl, m-menthanyl, quinuclidinyl, adamantanyl, noradamantanyl, bornyl, bicyclo[2.2.1]heptanyl, 2-oxobicyclo[2.2.1]heptanyl or bicyclo[2.2.1]heptenyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, azacyclooctyl, diazacycloheptanyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptanyl, 3,6-diazabicyclo[3.1.1]heptanyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl, 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof; orfuranyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl and imidazo[2,1-b]thiazolyl, with each group being optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, optionally substituted C3-15cycloalkyl, optionally substituted 4- to 15-membered heterocyclyl, optionally substituted C6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof, and wherein the C3-15cycloalkyl, the 4- to 15-membered heterocyclyl, the C6-15 aryl, and the 5- to 15-membered heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C1-4 alkoxy, C1-4 alkyl-NH—, halogenated C1-4 alkyl, NH2—C1-4 alkylene, C1-4 alkyl-NHC(O)—, C1-4 alkyl-C(O)NH—, or any combination thereof;orRb2 represents the following formula:

36. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, which is selected from the group consisting of: 3-(5-((4-(((3s,5s,7s)-adamantan-1-yl)amino)butyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((5-(((1s,3s)-adamantan-1-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((6-(((3s,5s,7s)-adamantan-1-yl)amino)hexyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(2-(((1s,3s)-adamantan-1-yl)amino)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(2-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethoxy)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(((1r,3r,5r,7r)-adamantan-2-yl)amino)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(((1r,3r,5r,7r)-adamantan-2-yl)amino)propyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((4-(((1r,3r,5r,7r)-adamantan-2-yl)amino)butyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((5-(((1r,3r,5r,7r)-adamantan-2-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((5-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((6-(((2R,3as,5S,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)hexyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(2-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(2-(2-(((2R,3as,5S,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethoxy)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((5-(4-methyl-1,4-diazepan-1-yl)pentyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((7-(4-methyl-1,4-diazepan-1-yl)heptyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((2-(2-(4-methyl-1,4-diazepan-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(2-hydroxyethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((2-(2-morpholinoethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((2-(2-(4-morpholinopiperidin-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((2-(2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((2-(2-(4-(oxetan-3-yl)piperazin-1-yl)ethoxy)ethyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-hydroxyheptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((7-(4-morpholinopiperidin-1-yl)heptyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((7-(4-(oxetan-3-yl)piperazin-1-yl)heptyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(3-azabicyclo[3.1.0]hexan-3-yl)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(2,2-difluoro-7-azaspiro[3.5]nonan-7-yl)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)amino)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-((2-isopropyl-5-methylcyclohexyl)oxy)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)amino)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(4-methyl-1,4-diazepan-1-yl)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(2-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethoxy)ethoxy)ethyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(2,2-difluoro-7-azaspiro[3.5]nonan-7-yl)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-((2-isopropyl-5-methylcyclohexyl)oxy)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)amino)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-((7-((2-isopropyl-5-methylcyclohexyl)oxy)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)amino)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-2-butyl-4-oxoquinazolin-3(4H)-yl) piperidine-2,6-dione;3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-2-(methyl-d3)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-(7-(((3s,5s,7s)-adamantan-1-yl)amino)heptyl)-5-bromo-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-(7-(((3s,5s,7s)-adamantan-1-yl)amino)heptyl)-5-fluoro-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;2-(7-(((3s,5s,7s)-adamantan-1-yl)amino)heptyl)-3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydroquinazoline-5-carbonitrile;3-(2-(3-(3-(((3s,5s,7s)-adamantan-1-yl)(methyl)amino)propoxy)propyl)-5-bromo-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(((1s,3s)-adamantan-1-yl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(4-(3-(((3s,5s,7s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-(4-(3-(((3s,5s,7s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;4-(4-(3-(2,4-dioxocyclohexyl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)piperazin-1-yl)-3-fluorobenzonitrile;3-(7-(4-(3-(((3s,5s,7s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(8-(4-(3-(((3s,5s,7s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(((2-((((3s,5s,7s)-adamantan-1-yl)amino)methyl)cyclopropyl);methyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-5-fluoro-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-2-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-((2-(((1s,3s)-adamantan-1-yl)amino)ethyl)thio)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((5-(((1s,3s)-adamantan-1-yl)amino)-3-oxopentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((5-(((1s,3s)-adamantan-1-yl)amino)-3,3-difluoropentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((5-(((1s,3s)-adamantan-1-yl)amino)-3-thioxopentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;2-(((3s,5s,7s)-adamantan-1-yl)amino)ethyl 3-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)propanoate;N-(4-(((3s,5s,7s)-adamantan-1-yl)(methyl)amino)butyl)-3-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)propanamide;3-(5-((2-((2-(((1s,3s)-adamantan-1-yl)amino)ethyl)amino)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-((2-(((1s,3s)-adamantan-1-yl)amino)ethyl)(methyl)amino)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-hydroxyheptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((7-(4-(oxetan-3-yl)piperazin-1-yl)heptyl)oxy)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-((7-(4-methylpiperazin-1-yl)heptyl)oxy)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)oxy)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)oxy)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(R)-3-(5-(2-(2-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethoxy)ethoxy)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)oxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-((7-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)oxy)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)oxy)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)thio)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-((7-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)heptyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)thio)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)heptyl)thio)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(((3s,5s,7s)-adamantan-1-yl)amino)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(5-hydroxypent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(5-(((3s,5s,7s)-adamantan-1-yl)amino)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-4-oxo-5-(5-(piperidin-1-yl)pent-1-yn-1-yl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(5-(4-methylpiperazin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(5-(4-(oxetan-3-yl)piperazin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(5-(4-methyl-1,4-diazepan-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(5-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(5-(4-morpholinopiperidin-1-yl)pent-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(5-((1-((1s,3s)-adamantan-1-yl)ethyl)amino)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-hydroxyoct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(8-(4-(oxetan-3-yl)piperazin-1-yl)oct-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(8-(4-methylpiperazin-1-yl)oct-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(8-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)oct-1-yn-1-yl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(5-hydroxypentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(5-(((3s,5s,7s)-adamantan-1-yl)amino)pentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(5-(4-(oxetan-3-yl)piperazin-1-yl)pentyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(5-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)pentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(5-(4-methylpiperazin-1-yl)pentyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)pentyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-hydroxyoctyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(8-(4-(oxetan-3-yl)piperazin-1-yl)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(8-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-5-(8-(4-methylpiperazin-1-yl)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(4-oxo-2-(trifluoromethyl)-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)octyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(4-oxo-2-(trifluoromethyl)-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)oct-1-yn-1-yl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(2-methyl-4-oxo-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)octyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(2-methyl-4-oxo-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)oct-1-yn-1-yl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-(8-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-(8-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-(8-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(5-(8-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-(8-((1-((3r,5r,7r)-adamantan-1-yl)ethyl)amino)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3R)-3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-(8-((2-isopropyl-5-methylcyclohexyl)oxy)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(3S)-3-(5-(8-((2-isopropyl-5-methylcyclohexyl)oxy)oct-1-yn-1-yl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(4-oxo-2-(trifluoromethyl)-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)octyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;(S)-3-(4-oxo-2-(trifluoromethyl)-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)oct-1-yn-1-yl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-(3-(((1s,3s)-adamantan-1-yl)amino)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-(5-(((1s,3s)-adamantan-1-yl)amino)pent-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-(5-(((1s,3s)-adamantan-1-yl)amino)pentyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-(8-(((3s,5s,7s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-(8-((1-((1s,3s)-adamantan-1-yl)ethyl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-(8-((1-((1s,3s)-adamantan-1-yl)ethyl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(7-(8-(((3s,5s,7s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(7-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(7-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(8-(8-(((3s,5s,7s)-adamantan-1-yl)amino)oct-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(8-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(8-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-2-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;(3r,5r,7r)-N-(5-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)pentyl)adamantane-1-carboxamide;N-((1s,3s)-adamantan-1-yl)-7-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)heptanamide;3-(5-((4-((((1s,3s)-adamantan-1-yl)amino)methyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((4-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((4-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(2-(4-((((3s,5s,7s)-adamantan-1-yl)amino)methyl)piperazin-1-yl)ethyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(2-(4-(2-(((1s,3s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)ethyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(2-(4-(3-(((3s,5s,7s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)ethyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-((((1s,3s)-adamantan-1-yl)amino)methyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-4-oxo-5-(piperazin-1-ylmethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(2-methyl-4-oxo-5-(3-(piperazin-1-yl)prop-1-yn-1-yl)quinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((4-(7-(((1s,3s)-adamantan-1-yl)amino)heptyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((3s,5s,7s)-adamantan-1-yl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(((1s,3s)-adamantan-1-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(2-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((4-(4-((3r,5r,7r)-adamantan-1-yl)benzyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((4-(2-((1s,3s)-adamantan-1-yl)ethyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(4-((3r,5r,7r)-adamantan-1-yl)benzyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(4-((3r,5r,7r)-adamantan-1-yl)benzyl)piperazin-1-yl)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(2-(4-((1s,3s)-adamantan-1-yl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(2-((1s,3s)-adamantan-1-yl)ethyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(2-((1s,3s)-adamantan-1-yl)ethyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)propyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(((1-((((1s,3s)-adamantan-1-yl)amino)methyl)cyclopropyl)methyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((4-(2-(((2R,3as,5S,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)ethyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((4-(3-(((3as,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)amino)propyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-((2-(((1s,3s)-adamantan-1-yl)amino)ethyl)(methyl)amino)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;N-((3s,5s,7s)-adamantan-1-yl)-2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)ethane-1-sulfonamide;N-((1s,3s)-adamantan-1-yl)-1-(1-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)piperidin-3-yl)methanesulfonamide;N-((3s,5s,7s)-adamantan-1-yl)-2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)thio)ethane-1-sulfonamide;N-((3s,5s,7s)-adamantan-1-yl)-2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)oxy)ethane-1-sulfonamide;N-((3s,5s,7s)-adamantan-1-yl)-3-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)propane-1-sulfonamide;N-((3s,5s,7s)-adamantan-1-yl)-3-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)propane-1-sulfonamide;3-(2-methyl-5-((4-((4-(oxetan-3-yl)piperazin-1-yl)sulfonyl)butyl)amino)-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(((3s,5s,7s)-adamantan-1-yl)amino)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(8-((2-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)ethyl)amino)-3-methyl-1-oxoisoquinolin-2(1H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-benzhydrylpiperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(7-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(8-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(6-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(7-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(8-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(6-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(8-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(5-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((1S,4S)-5-(2-((3S,5S,7S)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((1R,4R)-5-(2-((3R,5R,7R)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,5-dimethylpiperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,6-dimethylpiperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(trifluoromethyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(fluoromethyl)piperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,2-dimethylpiperazin-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-1,4-diazepan-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,5-dimethylpiperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,6-dimethylpiperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(trifluoromethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(fluoromethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,2-dimethylpiperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-1,4-diazepan-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(6-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(8-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(5-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-((1S,4S)-5-(2-((3S,5S,7S)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-((1R,4R)-5-(2-((3R,5R,7R)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,5-dimethylpiperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,6-dimethylpiperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3-(trifluoromethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(fluoromethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,2-dimethylpiperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-1,4-diazepan-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-benzhydrylpiperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((4′-chloro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((4′-fluoro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((4′-fluoro-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((4′-chloro-4-methoxy-4-methyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((4′-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((4′-chloro-4,4-difluoro-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((8-(4-chlorophenyl)spiro[4.5]dec-7-en-7-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((4′-chloro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((4′-fluoro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((4′-fluoro-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((4′-chloro-4-methoxy-4-methyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((4′-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((4′-chloro-4,4-difluoro-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((8-(4-chlorophenyl)spiro[4.5]dec-7-en-7-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((3-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)thio)ethyl)piperazin-1-yl)-3-fluorobenzonitrile;3-(5-((2-(4-(4-((1s,3s)-adamantan-1-yl)benzyl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(((1s,3s)-adamantan-1-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((2-(4-(4-((1s,3s)-adamantan-1-yl)benzyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)amino)ethyl)piperazin-1-yl)-3-fluorobenzonitrile;3-(5-(2-(4-((3s,5s,7s)-adamantan-1-yl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(2-(4-(4-((1s,3s)-adamantan-1-yl)benzyl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;4-(4-(2-((3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)oxy)ethyl)piperazin-1-yl)-3-fluorobenzonitrile;3-(5-((4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-((4-((1s,3s)-adamantane-1-carbonyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;3-(5-(3-(4-(2-((1s,3s)-adamantan-1-yl)ethyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; or3-(5-(3-(4-((3r,5r,7r)-adamantane-1-carbonyl)piperazin-1-yl)prop-1-yn-1-yl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione.

37. The compound of Formula (I) or salts, enantiomers, diastereoisomer, isotopically enriched analogs, solvates, prodrugs, or polymorphs thereof as claimed in claim 1, which is hydrochlorides, sulfates, citrates, maleates, sulfonates, citrates, lactates, tartrates, fumarates, phosphates, dihydrophosphates, pyrophosphates, metaphosphates, oxalates, malonates, benzoates, mandelates, succinates, trifluoroacetates, hydroxyacetates, or p-toluenesulfonates of the compound of Formula (I).

38. A pharmaceutical composition comprising the compound of Formula (I) or pharmaceutically acceptable salts thereof as claimed in claim 1, and at least one pharmaceutically acceptable carrier, and optionally further comprising at least one additional therapeutic agent, e.g., an anticancer agent.

39. A method for treating or preventing diseases or disorders associated with cereblon protein in a subject, comprising administering to the subject a therapeutically effective amount of the compound of Formula (I) or pharmaceutically acceptable salts thereof as claimed in claim 1, or the pharmaceutical composition comprising the compound of Formula (I) or a pharmaceutically acceptable salt thereof; preferably, wherein the diseases or disorders associated with cereblon protein are selected from the group consisting of: tumor, infectious disease, inflammatory disease, autoimmune disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, cardiovascular disease, Richter syndrome (RS), acute liver failure, or diabetes;more preferably, wherein diseases or disorders associated with cereblon protein are selected from the group consisting of: myeloma, including multiple myeloma, plasma cell myeloma, smoldering myeloma, smoldering multiple myeloma; myelofibrosis; bone marrow disease; myelodysplastic syndrome (MDS); previously treated myelodysplastic syndrome; transplantation-related cancer; neutropenia; leukemia, including acute myeloid leukemia, chronic myelogenous leukemia, B-cell chronic lymphocytic leukemia, leukemia-associated anemia, acute myeloid leukemia (AML); lymphoma, including diffuse large B-cell lymphoma, non-Hodgkin's lymphoma, Hodgkin's lymphoma, anaplastic lymphoma, anaplastic large cell lymphoma, CD20 positive lymphoma, mantle cell lymphoma, primary lymphoma, B-cell lymphoma, recurrent B-cell non-Hodgkin's lymphoma, recurrent diffuse large B-cell lymphoma, recurrent mediastinal (thymic) large B-cell lymphoma, primary mediastinal (thymic) large B-cell lymphoma, recurrent transformed non-Hodgkin's lymphoma, refractory B-cell non-Hodgkin's lymphoma, refractory diffuse large B-cell lymphoma, refractory primary mediastinal (thymic) large B-cell lymphoma, refractory transformed non-Hodgkin's lymphoma; thyroid cancer; melanoma; lung cancer, including lung adenocarcinoma, lung squamous cell carcinoma; inflammatory myofibroblastoma; colorectal cancer; intestinal cancer; brain glioma; astroblastoma; ovarian cancer; bronchial cancer; prostate cancer; breast cancer, including triple negative breast cancer, sporadic breast cancer and patients with Cowden syndrome; pancreatic cancer; central nervous system tumor; neuroblastoma; neuroglioma; Peripheral neuroepithelioma; extramedullary plasmacytoma; plasmacytoma; gastric cancer; gastrointestinal stromal tumors; esophageal cancer; colorectal adenocarcinoma; esophageal squamous cell carcinoma; liver cancer; renal cell carcinoma; bladder cancer; endometrial cancer; metrocarcinoma; head and neck cancer; brain cancer; oral cancer; sarcoma, including rhabdomyosarcoma, various lipogenic tumors, Ewing's sarcoma/primitive neuroectodermal tumors (Ewing/PNETs), and leiomyosarcoma; urothelial carcinoma; basal cell carcinoma; oral squamous cell carcinoma; cholangiocarcinoma; bone cancer; cervical cancer; skin cancer; Richter syndrome (RS); sepsis syndrome; autoimmune diseases, including rheumatoid arthritis, autoimmune encephalomyelitis, ankylosing spondylitis, psoriasis, systemic lupus erythematosus, multiple sclerosis, recurrent oral ulcers, Kawasaki disease, polymyositis/dermatomyositis, Sjogren's syndrome, and atopic dermatitis; keratoconjunctivitis; inflammatory diseases, including Crohn's disease and ulcerative colitis, pneumonia, osteoarthritis, synovitis, systemic inflammatory response syndrome, airway inflammation, bronchitis; cerebral malaria; infectious diseases, including viral pneumonia, Acquired immunodeficiency syndrome (AIDS), COVID-19 novel coronavirus infection, gram-negative bacteria infection, gram-positive bacteria infection, tuberculosis, etc.; septic shock; tuberculosis; bacterial meningitis; chronic obstructive pulmonary disease; asthma; hemorrhagic shock; organ (including kidney, heart, lung) or tissue transplantation rejection; diabetes; sarcoidosis; adult respiratory distress syndrome; anemia; pediatric aplastic anemia; cardiovascular diseases (e.g., coronary heart disease, congestive heart failure, myocardial infarction, atherosclerosis); multiple organ dysfunction caused by cachexia and septic shock; or acute liver failure.