Claims
- 1. A sulphamate compound suitable for use as an inhibitor of oestrone sulphatase, wherein the compound is a sulphamate compound having Formula IV;
- 2. A sulphamate compound suitable for use as an inhibitor of oestrone sulphatase, wherein the compound is a sulphamate compound having Formula II;
- 3. A sulphamate compound according to claim 2 wherein the compound has the Formula IV;
- 4. A sulphamate compound according to claim 1 wherein at least one of R3 and R4 is H.
- 5. A sulphamate compound according to claim 2 wherein at least one of R3 and R4 is H.
- 6. A sulphamate compound according to claim 1 wherein each of R3 and R4 is H.
- 7. A sulphamate compound according to claim 2 wherein each of R3 and R4 is H.
- 8. A sulphamate compound according to claim 1 wherein Y is —CH2— or —C(O)—.
- 9. A sulphamate compound according to claim 1 wherein Y is —C(O)—.
- 10. A sulphamate compound according to claim 1 wherein the compound has the Formula V;
- 11. A sulphamate compound according to claim 1 wherein each of R1 and R2 is independently selected from H, alkyl, cycloalkyl, alkenyl, aryl, substituted alkyl, substituted cycloalkyl, substituted alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy containing group.
- 12. A sulphamate compound according to claim 2 wherein
R1 is selected from alkyl, cycloalkyl, alkenyl, aryl, substituted alkyl, substituted cycloalkyl, substituted alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy containing group, and R2 is selected from H, alkyl, cycloalkyl, alkenyl, aryl, substituted alkyl, substituted cycloalkyl, substituted alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy containing group.
- 13. A sulphamate compound according to claim 1 wherein each of R1 and R2 is independently selected from H, C1-6 alkyl, C1-6 cycloalkyl, C1-6 alkenyl, substituted C1-6 alkyl, substituted C1-6 cycloalkyl, substituted C1-6 alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy group having from 1-6 carbon atoms.
- 14. A sulphamate compound according to claim 2 wherein
R1 is selected from C1-6 alkyl, C1-6 cycloalkyl, C1-6 alkenyl, substituted C1-6 alkyl, substituted C1-6 cycloalkyl, substituted C1-6 alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy group having from 1-6 carbon atoms, and R2 is selected from H, C1-6 alkyl, C1-6 cycloalkyl, C1-6 alkenyl, substituted C1-6 alkyl, substituted C1-6 cycloalkyl, substituted C1-6 alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy group having from 1-6 carbon atoms.
- 15. A sulphamate compound according to claim 1 wherein each of R1 and R2 is independently selected from H, C1-6 alkyl, C1-6 alkenyl, a nitrogen containing group, or a carboxy group having from 1-6 carbon atoms.
- 16. A sulphamate compound according to claim 2 wherein
R1 is selected from C1-6 alkyl, C1-6 alkenyl, a nitrogen containing group, or a carboxy group having from 1-6 carbon atoms, and R2 is selected from H, C1-6 alkyl, C1-6 alkenyl, a nitrogen containing group, or a carboxy group having from 1-6 carbon atoms.
- 17. A sulphamate compound according to claim 1 wherein each of R1 and R2 is independently selected from H, C1-6 alkyl, C1-6 alkenyl, NO2, or a carboxy group having from 1-6 carbon atoms.
- 18. A sulphamate compound according to claim 2 wherein
R1 is selected from C1-6 alkyl, C1-6 alkenyl, NO2, or a carboxy group having from 1-6 carbon atoms, and R2 is selected from H, C1-6 alkyl, C1-6 alkenyl, NO2, or a carboxy group having from 1-6 carbon atoms.
- 19. A sulphmate compound according to claim 1 wherein each of R1 and R2 is independently selected from H, C3 alkyl, C3 alkenyl, NO2, or H3CO.
- 20. A sulphamate compound according to claim 2 wherein
R1 is selected from C3 alkyl, C3 alkenyl, NO2, or H3CO, and R2 is selected from H, C3 alkyl, C3 alkenyl, NO2, or H3CO.
- 21. A sulphamate compound according to claim 1 wherein the compound is any one of the Formulae VI-IX.
- 22. A sulphamate compound according to claim 2 wherein the group A/ring B combination contains one or more alkoxy substituents.
- 23. A sulphamate compound according to claim 2 wherein the group A/ring B combination contains one or more methoxy substituents.
- 24. A sulphamate compound according to claim 1 wherein R1 and/or R2 is an alkoxy group.
- 25. A sulphamate compound according to claim 2 wherein R1 and/or R2 is an alkoxy group.
- 26. A sulphamate compound according to claim 1 wherein R1 and/or R2 is a methoxy group.
- 27. A sulphamate compound according to claim 2 wherein R1 and/or R2 is a methoxy group.
- 28. A sulphamate compound according to claim 1 wherein R1 is an alkoxy group.
- 29. A sulphamate compound according to claim 2 wherein R1 is an alkoxy group.
- 30. A sulphamate compound according to claim 1 wherein R1 is a methoxy group.
- 31. A sulphamate compound according to claim 2 wherein R1 is a methoxy group.
- 32. A method of inhibiting steroid sulphatase activity in a patient in need thereof comprising administering a sulphamate compound having Formula IV;
- 33. A method of inhibiting steroid sulphatase activity in a patient in need thereof comprising administering a sulphamate compound having Formula II;
- 34. A method according to claim 33 wherein the compound has the Formula IV;
- 35. A method according to claim 32 wherein the sulphamate group has the Formula III;
- 36. A method according to claim 33 wherein the sulphamate group has the Formula III;
- 37. A method according to claim 32 wherein at least one of R3 and R4 is H.
- 38. A method according to claim 33 wherein at least one of R3 and R4 is H.
- 39. A method according to claim 32 wherein each of R3 and R4 is H.
- 40. A method according to claim 33 wherein each of R3 and R4 is H.
- 41. A method according to claim 32 wherein Y is —CH2— or —C(O)—.
- 42. A method according to claim 32 wherein Y is —C(O)—.
- 43. A method according to claim 32 wherein the compound has the Formula V;
- 44. A method according to claim 32 wherein each of R1 and R2 is independently selected from H, alkyl, cycloalkyl, alkenyl, aryl, substituted alkyl, substituted cycloalkyl, substituted alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy containing group.
- 45. A method according to claim 33 wherein
R1 is selected from alkyl, cycloalkyl, alkenyl, aryl, substituted alkyl, substituted cycloalkyl, substituted alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy containing group, and R2 is selected from H, alkyl, cycloalkyl, alkenyl, aryl, substituted alkyl, substituted cycloalkyl, substituted alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy containing group.
- 46. A method according to claim 32 wherein each of R1 and R2 is independently selected from H, C1-6 alkyl, C1-6 cycloalkyl, C1-6 alkenyl, substituted C1-6 alkyl, substituted C1-6 cycloalkyl, substituted C1-6 alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy group having from 1-6 carbon atoms.
- 47. A method according to claim 33 wherein
R1 is selected from C1-6 alkyl, C1-6 cycloalkyl, C1-6 alkenyl, substituted C1-6 alkyl, substituted C1-6 cycloalkyl, substituted C1-6 alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy group having from 1-6 carbon atoms, and R2 is selected from H, C1-6 alkyl, C1-6 cycloalkyl, C1-6 alkenyl, substituted C1-6 alkyl, substituted C1-6 cycloalkyl, substituted C1-6 alkenyl, substituted aryl, a nitrogen containing group, a S containing group, or a carboxy group having from 1-6 carbon atoms.
- 48. A method according to claim 32 wherein each of R1 and R2 is independently selected from H, C1-6 alkyl, C1-6 alkenyl, a nitrogen containing group, or a carboxy group having from 1-6 carbon atoms.
- 49. A method according to claim 33 wherein
R1 is selected from C1-6 alkyl, C1-6 alkenyl, a nitrogen containing group, or a carboxy group having from 1-6 carbon atoms, and R2 is selected from H, C1-6 alkyl, C1-6 alkenyl, a nitrogen containing group, or a carboxy group having from 1-6 carbon atoms.
- 50. A method according to claim 32 wherein each of R1 and R2 is independently selected from H, C1-6 alkyl, C1-6 alkenyl, NO2, or a carboxy group having from 1-6 carbon atoms.
- 51. A method according to claim 33 wherein
R1 is selected from C-6 alkyl, C1-6 alkenyl, NO2, or a carboxy group having from 1-6 carbon atoms, and R2 is selected from H, C1-6 alkyl, C1-6 alkenyl, NO2, or a carboxy group having from 1-6 carbon atoms.
- 52. A method according to claim 32 wherein each of R1 and R2 is independently selected from H, C3 alkyl, C3 alkenyl, NO2, or H3CO.
- 53. A method according to claim 33 wherein
R1 is selected from C3 alkyl, C3 alkenyl, NO2, or H3CO, and R2 is selected from H, C3 alkyl, C3 alkenyl, NO2, or H3CO.
- 54. A method according to claim 32 wherein the compound is any one of the Formulae VI-IX.
- 55. A method according to claim 33 wherein the group A/ring B combination contains one or more alkoxy substituents.
- 56. A method according to claim 33 wherein the group A/ring B combination contains one or more methoxy substituents.
- 57. A method according to claim 32 wherein R1 and/or R2 is an alkoxy group.
- 58. A method according to claim 33 wherein R1 and/or R2 is an alkoxy group.
- 59. A method according to claim 32 wherein R1 and/or R2 is a methoxy group.
- 60. A method according to claim 33 wherein R1 and/or R2 is a methoxy group.
- 61. A method according to claim 32 wherein R1 is an alkoxy group.
- 62. A method according to claim 33 wherein R1 is an alkoxy group.
- 63. A method according to claim 32 wherein R1 is a methoxy group.
- 64. A method according to claim 33 wherein R1 is a methoxy group.
Priority Claims (3)
Number |
Date |
Country |
Kind |
9625334.9 |
Dec 1996 |
GB |
|
9812535.4 |
Jun 1998 |
GB |
|
9910167.7 |
Apr 1999 |
GB |
|
RELATED APPLICATIONS
[0001] This application is a continuation-in-part of allowed U.S. application Ser. No. 09/319,213, filed Nov. 23, 1999, which is a continuation-in-part of allowed U.S. application Ser. No. 09/111,927, filed Jul. 8, 1998, now U.S. Pat. No. 6,011,024, and a continuation-in-part of PCT/GB97/03352, filed Dec. 4, 1997, designating the U.S. and published as WO 98/24802, with a claim of priority from Great Britain application no. 9625334.9, filed Dec. 5, 1996. This application is also a continuation-in-part of allowed U.S. application Ser. No. 09/724,986, filed Nov. 28, 2000, which is a continuation-in-part of PCT/GB99/01835, filed Jun. 10, 1999, designating the U.S. and published as WO 99/64013, with claims of priority from Great Britain application nos. 9812535.4, filed Jun. 10, 1998 and 9910167.7 filed Apr. 30, 1999. All of the foregoing applications, as well as all documents cited in the foregoing applications (“application documents”) and all documents cited or referenced in application documents are hereby incorporated herein by reference. Also, all documents cited in this application (“herein cited documents”) and all documents cited or referenced in herein cited documents are hereby incorporated herein by reference.
Continuation in Parts (5)
|
Number |
Date |
Country |
Parent |
09319213 |
Nov 1999 |
US |
Child |
10674892 |
Sep 2003 |
US |
Parent |
09111927 |
Jul 1998 |
US |
Child |
09319213 |
Nov 1999 |
US |
Parent |
PCT/GB97/03352 |
Dec 1997 |
US |
Child |
09319213 |
Nov 1999 |
US |
Parent |
09724986 |
Nov 2000 |
US |
Child |
10674892 |
Sep 2003 |
US |
Parent |
PCT/GB99/01835 |
Jun 1999 |
US |
Child |
09724986 |
Nov 2000 |
US |