Claims
- 1. A method of eliciting an analgesic effect in a host animal in need thereof, comprising the step of:
- administering to said host animal an effective dose of a compound, or a pharmaceutically acceptable salt thereof, having the formula: ##STR3## where X is nitrogen, or a carbon bonded to a substituent species characterized as having a sigma m value between about -0.3 and about 0.75; n is an integer value of 1 to 7; m and p are integers individually having values of 0 or 1; E' and E" individually represent hydrogen or a substituted or an unsubstituted alkyl group containing one to five carbon atoms; Z' and Z" individually represent hydrogen or an alkyl group containing one to five carbon atoms; A, A', A" individually represent a hydrogen, an alkyl group, or a halogen atom; and the wavy line in said formula represents a cis (Z) or trans (E) form of said compound.
- 2. The method of claim 1 wherein said host is a mammal.
- 3. The method of claim 1 wherein said host is human and said effective dose of said compound ranges from about 1 mg/24 hr./patient to about 500 mg/24 hr./patient.
- 4. A method of eliciting an analgesic effect in a host animal in need thereof comprising the step of:.
- administering to said host animal an effective dose of a compound or a pharmaceutically acceptable salt thereof having the formula; ##STR4## where X is nitrogen, or a carbon bonded to a substituent species characterized as having a sigma m value between about -0.3 and about 0.75; n is an integer value of 1 to 7; m and p are integers individually having values of 0 or 1; E' and E" individually represent hydrogen or a substituted or an unsubstituted alkyl group containing one to five carbon atoms; Z' and Z" individually represent hydrogen or an alkyl group containing one to five carbons; A, A', and A" individually represent a hydrogen, an alkyl group, or a halogen atom; and the wavy line in said formula represents a cis (Z) or trans (E) form of said compound, wherein said step of administration is performed by injection.
- 5. The method of claim 1 wherein X is selected from the group consisting of N, C--H, C--F, C--Cl, C--Br, C--I, C--NR'R", C--F.sub.3, C--OH, C--CN, C--SH, C--SCH.sub.3, C--N.sub.3, C--SO.sub.2 CH.sub.3, C--OR', C--C(.dbd.O)NR'R", C--NR'C(.dbd.O)R', C--C(.dbd.O)OR', C--OC(.dbd.O)R', C--OC(.dbd.O)NR'R" and C--NR'C(.dbd.O)OR' where R' and R" are individually hydrogen or alkyl containing one to five carbon atoms.
- 6. The method of claim 1 further comprising dispersing or dissolving said compound in a pharmaceutically acceptable carrier prior to the step of administering to said host animal said effective dose of said compound.
- 7. A method of eliciting an analgesic effect in a host animal in need thereof, comprising the step of:
- administering to said host animal an effective dose of a compound, or a pharmaceutically acceptable salt thereof, having the formula: ##STR5## where X is nitrogen, or a carbon bonded to a substituent species characterized as having a sigma m value between about -0.3 and about 0.75; n is 2 or 3, and the wavy line in said formula represents a cis (Z) or trans (E) form of said compound.
- 8. The method of claim 7 wherein said compound is selected from the group consisting of (E)-N-methyl-4-(3-(pyridin)yl)-3-buten-1-amine), (Z)-N-methyl-4-(3-(pyridin)yl)-3-buten-1-amine), and combinations thereof.
- 9. The method of claim 7 wherein said host is a mammal.
- 10. The method of claim 7 wherein said host is human and said effective dose of said compound ranges from about 1 mg/24 hr./patient to about 500 mg/24 hr./patient.
- 11. A method of eliciting an analgesic effect in a host animal in need thereof, comprising the step of:
- administering to said host animal an effective dose of a compound, or a pharmaceutically acceptable salt thereof, having the formula: ##STR6## where X is nitrogen, or a carbon bonded to a substituent species characterized as having a sigma m value between about -0.3 and about 0.75; n is 2 or 3, and the wave line in said formula represents a cis (Z) or trans (E) form of said compound, wherein said step of administration is performed by a injection.
- 12. The method of claim 7 wherein X is selected from the group consisting of N, C--H, C--F, C--Cl, C--Br, C--I, C--NR'R", C--F.sub.3, C--OH, C--CN, C--SH, C--SCH.sub.3, C--N.sub.3, C--SO.sub.2 CH.sub.3, C--OR', C--C(.dbd.O)NR'R", C--NR'C(.dbd.O)R', C--C(.dbd.O)OR', C--OC(.dbd.O)R', C--OC(.dbd.O)NR'R" and C--NR'C(.dbd.O)OR', where R' and R" are individually hydrogen or alkyl containing one to five carbon atoms.
Parent Case Info
This application is a continuation of Ser. No. 08/908,440, filed Aug. 7, 1997, now U.S. Pat. No. 5,914,337.
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5604231 |
Smith et al. |
Feb 1997 |
|
5616716 |
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Non-Patent Literature Citations (1)
Entry |
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Continuations (1)
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Number |
Date |
Country |
Parent |
908440 |
Aug 1997 |
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