Claims
- 1. A compound of the formula ##STR12## or a physiologically acceptable salt thereof, wherein R.sub.1 is hydroxy-lower alkylene, hydroxyphenyl-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkylmercapto-lower alkylene, carbamoyl-lower alkylene or carboxy-lower alkylene;
- R.sub.2 and R.sub.3 each is hydrogen, lower alkyl or phenyl-lower alkylene; and
- R.sub.5 is hydrogen, lower alkanoyl, benzoyl or ##STR13## with the proviso that if R.sub.2 and R.sub.5 are both hydrogen and R.sub.3 is methyl, R.sub.1 is not mercapto-lower alkylene.
- 2. A compound of the formula ##STR14## or a physiologically acceptable salt thereof, wherein R.sub.1 is lower alkyl, phenyl-lower alkylene, hydroxy-lower alkylene, hydroxyphenyl-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkylmercapto-lower alkylene, carbamoyl-lower alkylene or carboxy-lower alkylene;
- R.sub.2 and R.sub.3 each is hydrogen, lower alkyl or phenyl-lower alkylene; and
- R.sub.5 is hydrogen, lower alkanoyl, benzoyl or ##STR15##
- 3. A compound of the formula ##STR16## or a physiologically acceptable salt thereof, wherein R.sub.1 is hydrogen, lower alkyl, phenyl-lower alkylene, hydroxy-lower alkylene, hydroxyphenyl-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercaptolower alkylene, lower alkylmercapto-lower alkylene, carbamoyllower alkylene, or carboxy-lower alkylene;
- R.sub.2, R.sub.3 and R.sub.4 each is hydrogen, lower alkyl or phenyl-lower alkylene; and
- R.sub.5 is hydrogen, lower alkanoyl, benzoyl or ##STR17##
- 4. A compound as in claim 2 wherein R.sub.1 is guanidino-lower alkylene, amino-lower alkylene, phenyl-lower alkylene or lower alkyl; R.sub.2 and R.sub.5 each is hydrogen; and R.sub.3 is hydrogen, lower alkyl or phenyl-lower alkylene.
- 5. A compound as in claim 2 wherein R.sub.1 is guanidinopropyl, aminopropyl, aminobutyl, phenylmethyl, or isobutyl; R.sub.2 and R.sub.5 each is hydrogen; and R.sub.3 is hydrogen, lower alkyl or phenyl-lower alkylene.
- 6. A compound as in claim 2 wherein R.sub.1 is phenylmethyl and R.sub.2, R.sub.3 and R.sub.5 each is hydrogen.
- 7. A compound as in claim 2 wherein R.sub.1 is isobutyl and R.sub.3 is hydrogen.
- 8. A compound as in claim 2 wherein R.sub.1 is guanidinopropyl and R.sub.2, R.sub.3 and R.sub.5 each is hydrogen.
- 9. A compound as in claim 2 wherein R.sub.5 is ##STR18##
- 10. A compound as in claim 9 wherein each R.sub.1 is guanidinopropyl.
- 11. A compound as in claim 9 wherein each R.sub.1 is isopropyl.
- 12. A compound as in claim 6 wherein R.sub.2 and R.sub.5 each is hydrogen having the name N-(3-mercaptopropanoyl)-L-phenylalanine.
- 13. A compound as in claim 7 wherein R.sub.2 and R.sub.5 each is hydrogen having the name N-(3-mercaptopropanoyl)-L-leucine.
- 14. A compound as in claim 8, wherein R.sub.2 and R.sub.5 each is hydrogen having the N.sup..alpha. -(3-mercaptopropanoyl)-L-arginine.
- 15. A compound as in claim 2 wherein R.sub.1 is guanidinopropyl, R.sub.2 and R.sub.5 each is hydrogen and R.sub.3 is methyl having the name N.sup..alpha. -(3-mercapto-2-methylpropanoyl)-L-arginine.
- 16. A compound as in claim 10 wherein each R.sub.2 is hydrogen and each R.sub.3 is methyl, having the name N.sup..alpha., N.sup..alpha.' -[dithio-3,3'-bis(2-methylpropanoyl)]-bis-L-arginine.
- 17. A compound as in claim 11 wherein each R.sub.2 is hydrogen and each R.sub.3 is methyl having the name N,N'-[dithio-3,3'-bis(2-methylpropanoyl)]-bis-L-valine.
- 18. A compound as in claim 2 wherein R.sub.1 is hydroxyphenyl-lower alkylene.
- 19. A compound as in claim 2 wherein R.sub.1 is (4-hydroxyphenyl)methyl, R.sub.2 and R.sub.5 each is hydrogen and R.sub.3 is methyl having the name N-(3-mercapto-2-methylpropanoyl)-L-tyrosine.
- 20. A compound as in claim 2 wherein R.sub.1 is (3,4-dihydroxyphenyl)methyl, R.sub.2 and R.sub.5 each is hydrogen and R.sub.3 is methyl having the name 3-hydroxy-N-(DL-3-mercapto-2-methylpropanoyl)-L-tyrosine.
- 21. A compound as in claim 2 wherein R.sub.1 is (3,4-dihydroxyphenyl)methyl and R.sub.2, R.sub.3 and R.sub.5 each is hydrogen having the name 3-hydroxy-N-(3-mercaptopropanoyl)-L-tyrosine.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 773,864, filed Mar. 3, 1977, now abandoned, which is a division of application Ser. No. 684,606, filed May 10, 1976, now U.S. Pat. No. 4,053,651, issued Oct. 11, 1977.
US Referenced Citations (9)
Foreign Referenced Citations (2)
Number |
Date |
Country |
2709820 |
Sep 1977 |
DEX |
1491204 |
Jul 1967 |
FRX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
684606 |
May 1976 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
773864 |
Mar 1977 |
|