Claims
- 1. A compound of the formula ##STR15## and salts thereof, wherein R.sub.6 is hydrogen, formyl, or lower alkyl;
- R.sub.7 is hydrogen, halogen, hydroxy or lower alkoxy;
- R.sub.2, R.sub.3 and R.sub.4 each is hydrogen, lower alkyl, or phenyllower alkylene;
- R.sub.5 is hydrogen, lower alkanoyl, benzoyl or ##STR16## and n is 0, 1 or 2.
- 2. A compound of the formula ##STR17## or salt thereof, wherein n is 0; R.sub.1 is indol-3-yl-lower alkylene;
- R.sub.2, R.sub.3 and R.sub.4 each is hydrogen, lower alkyl or phenyl-lower alkylene; and
- R.sub.5 is hydrogen, lower alkanoyl, benzoyl or ##STR18##
- 3. A compound of the formula ##STR19## or salt thereof, wherein n is 1; R.sub.1 is indol-3-yl-lower alkylene;
- R.sub.2 and R.sub.3 each is hydrogen, lower alkyl, or phenyl-lower alkylene;
- R.sub.4 is hydrogen; and
- R.sub.5 is hydrogen, lower alkanoyl, benzoyl, or ##STR20##
- 4. A compound of the formula ##STR21## or salt thereof, wherein n is 2; R.sub.1 is indol-3-yl-lower alkylene;
- R.sub.2, R.sub.3 and R.sub.4 each is hydrogen, lower alkyl, or phenyl-lower alkylene; and
- R.sub.5 is hydrogen, lower alkanoyl, benzoyl or ##STR22##
- 5. A compound as in claim 3 wherein R.sub.1 is indol-3-yl-lower alkylene; R.sub.2 and R.sub.5 each is hydrogen; and R.sub.3 is hydrogen, lower alkyl or phenyl-lower alkylene.
- 6. A compound as in claim 1 wherein the substituent R.sub.7 is at the 5- or 6-position of the indolyl group.
- 7. A compound as in claim 3 wherein R.sub.2, R.sub.3 and R.sub.4 each is hydrogen and R.sub.5 is benzoyl, having the name N-(3-benzoylthiopropanoyl)tryptophan.
- 8. A compound as in claim 3 wherein R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each is hydrogen, having the name N-(3-mercaptopropanoyl)tryptophan.
- 9. A compound as in claim 3 wherein R.sub.2, R.sub.4 and R.sub.5 each is hydrogen and R.sub.3 is methyl, having the name N-(3-mercapto-2-methylpropanoyl)tryptophan.
- 10. A compound as in claim 2 wherein R.sub.2, R.sub.4 and R.sub.5 each is hydrogen and R.sub.3 is methyl, having the name N-(2-mercaptopropanoyl)tryptophan.
- 11. A compound as in claim 2 wherein R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each is hydrogen, having the name N-(2-mercaptoacetyl)-tryptophan.
- 12. A compound as in claim 6 wherein R.sub.1 is 5-methoxyindol-3-ylmethyl; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each is hydrogen; and n is 1, having the name N-(3-mercapto-1-oxopropyl)-5-methoxytryptophan.
- 13. A compound as in claim 6 wherein R.sub.1 is 5-bromoindol-3-ylmethyl, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each is hydrogen, and n is 1, having the name 5-bromo-N-(3-mercapto-1-oxopropyl)tryptophan.
- 14. A compound as in claim 6 wherein R.sub.1 is 1-methylindol-3-ylmethyl, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each is hydrogen, and n is 1, having the name N-(3-mercapto-1-oxopropyl)-1-methyltryptophan.
- 15. A compound as in claim 6 wherein R.sub.1 is 5-hydroxyindol-3-ylmethyl, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each is hydrogen, and n is 1, having the name 5-hydroxy-N-(3-mercapto-1-oxopropyl)tryptophan.
- 16. A compound as in claim 6 wherein R.sub.1 is 6-fluoroindol-3-ylmethyl, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each is hydrogen, and n is 1, having the name 6-fluoro-N-(3-mercapto-1-oxopropyl)tryptophan.
- 17. A compound as in claim 6 wherein R.sub.1 is 1-formylindol-3-ylmethyl, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each is hydrogen, and n is 1, having the name 1-formyl-N-(3-mercapto-1-oxopropyl)tryptophan.
- 18. A compound as in claim 1 wherein R.sub.5 is ##STR23##
Parent Case Info
This application is a continuation-in-part of application Ser. No. 876,977, filed Feb. 13, 1978 now abandoned, which is a division of application Ser. No. 773,864, filed Mar. 3, 1977, which in turn is a division of application Ser. No. 684,606, filed May 10, 1976, now U.S. Pat. No. 4,053,651 issued Oct. 11, 1977.
US Referenced Citations (9)
Non-Patent Literature Citations (10)
Entry |
Oparil et al., New Eng. J. Med. 241, 389-457 (1974). |
Erods, Circulation Research 36, 247-255 (1975). |
Garras et al. New Eng. J. Med. 291 817 (1974). |
Ripa, Proc. Int. Symp. Thiola, Osaka, Japan, 1920. |
Shulze, Arzeim Forsch 22, 1433 (1972). |
Schwartz, "Methods in Pharmacology" (Appleton-Century Crofts, NY) pp. 125-126. |
Berger, ed. Selected Pharmacological Testing Methods vol. 3, 169-194. |
Fugimara et al. Nippon Yakurigaku Zassh. 60, 278-292 (1964). |
Kunz et al. Chem. Abs. 86, 73114a (1976). |
Vasilevskii et al. Z Organischoskoi Khimii 2, 244-249 (1970). |
Divisions (2)
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Number |
Date |
Country |
Parent |
773864 |
Mar 1977 |
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Parent |
684606 |
May 1976 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
876977 |
Feb 1978 |
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