Claims
- 1-19. (Cancelled)
- 20. A compound having the following structure:
- 21. The compound of claim 20, wherein the carbohydrate moiety is selected from the group consisting of a glucosyl, glucosidyl, maltosyl, glucopyranosidyl, glyceraldehydyl, erythrosyl, arabinosyl, ribolucosyl, fructosyl, erythritolyl, xylosyl, lyxosyl, allosyl, altrosyl, mannosyl, mannosidyl, gulosyl, idosyl, galactosyl and talosyl.
- 22. The compound of claim 20, wherein X is C.
- 23. The compound of claim 20, wherein substituents for the substituted C(1-10) alkyl, C(2-10) alkenyl, C(2-10) alkynyl, C(1-10) alkoxyl, C(1-10) oxoalkyl, and heterocylic groups are selected from the group consisting of amino, C(2-6) alkenyl, C(1-6) alkyl, C(1-6) alkoxyl, C(1-6) hydroxyalkyl, C(1-6) oxoalkyl, azido, cyano, C(1-6) haloalkyl, isocyano, isothiocyano, imino, alkylthio, chlorine, bromine, fluorine and oxygen atom.
- 24. The compound of claim 23, wherein the C(1-6) haloalkyl is a mono-, di- or trihaloalkyl and the C(1-6) alkoxyl is a methoxy or ethoxy group.
- 25. The compound of claim 20, wherein one or two, nonadjacent carbon atoms of R2 are replaced with oxygen atoms.
- 26. The compound of claim 20, wherein the carbocyclic or heterocyclic group is selected from the group consisting of phenyl, biphenyl, cyclohexyl, cyclohexenyl, cyclopentyl, cyclopentenyl, cyclopentanedionyl, napthlalenyl, phenolyl, quinonyl, cyclobutyl, cycloheptyl, cycloheptenyl, indanyl, indenyl, decalinyl, resorcinolyl, tetralinyl, α-tetralonyl, 1-indanonyl, cyclohexanedionyl, cyclopentanedionyl, phthalimidyl, homophthalimidyl, quinazolinonyl, glutarimidyl, piperidonyl, succinimidyl, dimethoxyphenyl, methyldihydrouracilyl, methyluracilyl, methylthyminyl, piperidinyl, and dihydroxybenzenyl.
- 27. The compound of claim 20, wherein the other R5, other than ═O, is trimethoxy-substituted phenyl.
- 28. The compound of claim 20, wherein said compound is selected from:
- 29. A pharmaceutical composition comprising a pharmaceutically acceptable excipient or carrier and a compound having the following structure:
- 30. The pharmaceutical composition of claim 29, wherein the pharmaceutical composition is formulated for oral administration.
- 31. The pharmaceutical composition of claim 29, wherein R5 is trimethoxy-substituted phenyl.
- 32. A compound having the following structure:
- 33. A compound according to claim 20, wherein R2 and R3 are methyl, and wherein R6 is a
substituted or unsubstituted C(1-10) alkyl, C(2-10) alkenyl, C(2-10) alkynyl, or C(1-10) oxoalkyl; substituted or unsubstituted heterocylic group, attached to X through an atom within the ring, having one or two rings, each ring containing from four to seven atoms, and a single nitrogen as the heteroatom; or substituted or unsubstituted carbocyclic group that is attached to X through a carbon atom within a ring, having one ring containing four to seven atoms, wherein the substituents of said substituted carbocyclic group are selected from the group consisting of amino, C(2-6) alkenyl, C(1-6) alkyl, C(1-6) alkoxyl, C(1-6) hydroxyalkyl, hydroxyl, C(1-6) oxoalkyl, azido, cyano, C(2-6) mono- or di-haloalkyl, isocyano, isothiocyano, imino, a chlorine atom, a bromine atom, a fluorine atom and an oxygen atom.
- 34. A compound according to claim 20, wherein R3 is methyl.
- 35. A compound according to claim 34, wherein R2 is methyl.
- 36. A compound according to claim 35, wherein X is S.
- 37. A compound according to claim 36, wherein members of Group Q are independently selected from the group consisting of an hydroxyl group, substituted or unsubstituted C(3-10) alkyl C(2-10) alkenyl, C(2-10) alkynyl, C(1-10) alkoxyl, C(1-10) oxoalkyl, C(1-10) carboxyalkyl, C(1-10) hydroxyalkyl; and a substituted C(1-2) alkyl group.
- 38. A compound according to claim 37, wherein the other R5 is OH.
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application is a Continuation-in-Part Application of U.S. application Ser. Nos. 08/199,368 and 08/306,091, filed Feb. 18, 1994 and Sep. 14, 1994, respectively.
Continuations (3)
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Number |
Date |
Country |
Parent |
08932834 |
Sep 1997 |
US |
Child |
10838296 |
May 2004 |
US |
Parent |
08328632 |
Oct 1994 |
US |
Child |
08932834 |
Sep 1997 |
US |
Parent |
08199368 |
Feb 1994 |
US |
Child |
08306091 |
Sep 1994 |
US |
Continuation in Parts (1)
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Number |
Date |
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Parent |
08306091 |
Sep 1994 |
US |
Child |
08328632 |
Oct 1994 |
US |