Claims
- 1. A compound selected from the group consisting of:
1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-isopropyl-6-methyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2,6-dimethyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-3-[1,2,4]triazol-4-yl-phenyl)-3-[4-(pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-oxo-2H-pyran-4-yloxy)-naphthalen-1-yl]-urea; 5-tert-Butyl-2-methoxy-3-{3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-ureido}-benzoic acid; Carbonic acid 5-tert-butyl-2-methoxy-3-{3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-ureido}-phenyl ester methyl ester; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(4-isopropylamino-[1,3,5]triazin-2-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[4-(cyclopropylmethyl-amino)-[1,3,5]triazin-2-yloxy]-naphthalen-1-yl}-urea; 1-[4-(4-Amino-[1,3,5]triazin-2-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-([1,3,5]triazin-2-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-cyclopropylamino-6-methyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-methylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-ethylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(6-methyl-2-methylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-[4-(2-Amino-6-methyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-[4-(2-Amino-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-cyclopentylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(cyclopropylmethyl-amino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{2-[(tetrahydro-furan-2-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{2-[(pyridin-2-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-[4-(2-Benzylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-[4-(2-sec-Butylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-methoxy-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-dimethylamino-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-dimethylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-pyrrolidin-1-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(6-methyl-2-pyrrolidin-1-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-morpholin-4-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-ethoxy-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-dimethylamino-ethoxy)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-[4-(2-Benzylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-3-[1,2,4]triazol-4-yl-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-methanesulfinyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-methylsulfanyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(2-Methoxy-5-trimethylsilanyl-phenyl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-methoxy-phenyl)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(3-methoxy-phenyl)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-phenyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 4-{4-[3-(5-tert-Butyl-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidine-2-carboxylic acid methyl ester; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-cyano-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(tetrahydro-pyran-4-yloxy)-naphthalen-1-yl]-urea or the pharmaceutically acceptable derivatives thereof.
- 2. A compound selected from the group consisting of:
1-[5tert-Butyl-3-(1,1-dioxo-1-lambda-6-isothiazolidin-2-yl)-2-methoxy-phenyl]-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-urea; N-(3-{3-[4-(2-Amino-6-methyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide; N-(3-{3-[4-(2-Amino-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide; N-(5-tert-Butyl-3-{3-[4-(2-cyano-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-2-methoxy-phenyl)-methanesulfonamide; N-(5-tert-Butyl-2-methoxy-3-{3-[4-(tetrahydropyran-4-yloxy)-naphthalen-1-yl]-ureido}-phenyl)-methanesulfonamide N-(5-tert-Butyl-2-methoxy-3-{3-[4-(pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-phenyl)-methanesulfonamide; N-(5-tert-Butyl-2-methoxy-3-{3-[4-(2-methylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-phenyl)-methanesulfonamide; N-(5-tert-Butyl-2-methoxy-3-{3-[4-(6-methyl-2-methylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-phenyl)-methanesulfonamide; N-[5-tert-Butyl-3-(3-{4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-2-methoxy-phenyl]-methanesulfonamide; N-[5-tert-Butyl-3-(3-{4-[2-(cyclopropylmethyl-amino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-2-methoxy-phenyl]-methanesulfonamide; N-{5-tert-Butyl-2-methoxy-3-[3-(4-{2-[(tetrahydro-furan-2-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-ureido]-phenyl}-methanesulfonamide; N-(5-tert-Butyl-2-methoxy-3-{3-[4-(2-pyrrolidin-1-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-phenyl)-methanesulfonamide or the pharmaceutically acceptable derivatives thereof.
- 3. A compound selected from the group consisting of:
1-[5-tert-butyl-2-(2-hydroxy-4-methyl-phenyl)-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; 1-[5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl]-3-{4-[2-(hydroxy)ethoxy]-naphthalen-1-yl}-urea; 1-[5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl]-3-{4-[2-oxo-2-(morpholin-4-yl)-ethoxy]-naphthalen-1-yl}-urea; 1-[5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl]-3-{4-[hydroxy]-naphthalen-1-yl}-urea or the pharmaceutically acceptable derivatives thereof.
- 4. A compound selected from the group consisting of:
1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-isopropylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-cyclopropylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(1-phenyl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{2-[pyridin-3-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{2-[pyridin-4-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{2-[2-(4-methyl-piperazin-1-yl)-ethylamino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-pyrrolidin-1-yl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-oxo-tetrahydro-furan-3-ylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(tetrahydro-furan-3-ylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{6-methyl-2-[(tetrahydro-furan-2-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-methoxy-1-methyl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 2-(4-{4-[3-(5-tert-Butyl-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidin-2-ylamino)-propionamide; 2-(4-{4-[3-(5-tert-Butyl-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidin-2-ylamino)-N-methyl-propionamide; 2-(4-{4-[3-(5-tert-Butyl-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidin-2-ylamino)-N,N-dimethyl-propionamide; 2-(4-{4-[3-(5-tert-Butyl-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidin-2-ylamino)-N,N-dimethyl-acetamide 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{2-[1-(3-methoxy-phenyl)-ethylamino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-(4-{2-[1-(2-Bromo-phenyl)-ethylamino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(4-diethylamino-1-methyl-butylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(4-methoxy-benzylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(3-chloro-benzylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-{4-[2-(Benzyl-methyl-amino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{2-[(2-dimethylamino-ethyl)-methyl-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-[4-(2-Benzylamino-6-methyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[6-methyl-2-(1-phenyl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-(4-{6-methyl-2-[(pyridin-2-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(2-dimethylamino-ethylamino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[6-methyl-2-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-[4-(2-dimethylamino-6-methyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; N-(5-tert-Butyl-2-methoxy-3-{3-[4-(2-morpholin-4-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-phenyl)-methanesulfonamide; N-[5-tert-Butyl-2-methoxy-3-(3-{4-[2-(1-phenyl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-phenyl]-methanesulfonamide; N-[5-tert-Butyl-2-methoxy-3-(3-{4-[6-methyl-2-(1-phenyl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-phenyl]-methanesulfonamide; N-{5-tert-Butyl-2-methoxy-3-[3-(4-{2-[(pyridin-3-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-ureido]-phenyl}-methanesulfonamide; N-[5-tert-Butyl-3-(3-{4-[2-(2-dimethylamino-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-2-methoxy-phenyl]-methanesulfonamide; N-[5-tert-Butyl-3-(3-{4-[2-(2-dimethylamino-ethylamino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-2-methoxy-phenyl]-methanesulfonamide; N-[5-tert-Butyl-2-methoxy-3-(3-{4-[2-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-phenyl]-methanesulfonamide; N-[5-tert-Butyl-2-methoxy-3-(3-{4-[6-methyl-2-(2-morpholin-4-yl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-phenyl]-methanesulfonamide; N-(5-tert-Butyl-3-{3-[4-(2-dimethylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-2-methoxy-phenyl)-methanesulfonamide; N-[5-tert-Butyl-2-methoxy-3-(3-{4-[2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-phenyl]-methanesulfonamide; N-(5-tert-Butyl-2-methoxy-3-{3-[4-(2-piperidin-1-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-phenyl)-methanesulfonamide; N-{5-tert-Butyl-3-[3-(4-{2-[(2-dimethylamino-ethyl)-methyl-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-ureido]-2-methoxy-phenyl}-methanesulfonamide; N-[5-tert-Butyl-2-methoxy-3-(3-{4-[2-(tetrahydrofuran-3-ylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-phenyl]-methanesulfonamide; N-[5-tert-Butyl-2-methoxy-3-(3-{4-[2-(2-methoxy-1-methyl-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-phenyl]-methanesulfonamide; 2-(4-{4-[3-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidin-2-ylamino)-N-methyl-propionamide; 2-(4-{4-[3-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidin-2-ylamino)-N,N-dimethyl-propionamide; N-{5-tert-Butyl-2-methoxy-3-[3-(4-{2-[(pyridin-2-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-ureido]-phenyl}-methanesulfonamide; N-{5-tert-Butyl-2-methoxy-3-[3-(4-{6-methyl-2-[(tetrahydro-furan-2-ylmethyl)-amino]-pyrimidin-4-yloxy}-naphthalen-1-yl)-ureido]-phenyl}-methanesulfonamide; N-(5-tert-Butyl-2-methoxy-3-{3-[4-(6-methyl-2-pyrrolidin-1-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-phenyl)-methanesulfonamide; 2-(5-tert-Butyl-2-methoxy-3-{3-[4-(pyridin-4-yloxy)-naphthalen-1-yl]-ureido}-phenylamino)-thiazole-4-carboxylic acid ethyl ester; 2-(5-tert-Butyl-2-methoxy-3-{3-[4-(2-pyrrolidin-1-ylmethyl-pyridin-4-yloxy)-naphthalen-1-yl]-ureido}-phenylamino)-thiazole-4-carboxylic acid ethyl ester; 2-[5-tert-Butyl-2-methoxy-3-(3-{4-[2-(pyrrolidine-1-carbonyl)-pyridin-4-yloxy]-naphthalen-1-yl}-ureido)-phenylamino]-thiazole-4-carboxylic acid ethyl ester; 2-(5-tert-Butyl-2-methoxy-3-{3-[4-(2-methylaminomethyl-pyridin-4-yloxy)-naphthalen-1-yl]-ureido }-phenylamino)-thiazole-4-carboxylic acid ethyl ester; 2-(5-tert-Butyl-2-methoxy-3-{3-[4-(2-methylcarbamoyl-pyridin-4-yloxy)-naphthalen-1-yl]-ureido}-phenylamino)-thiazole-4-carboxylic acid ethyl ester; 2-(5-tert-Butyl-2-methoxy-3-{3-[4-(2-methylamino-pyridin-4-yloxy)-naphthalen-1-yl]-ureido}-phenylamino)-thiazole-4-carboxylic acid ethyl ester; 1-{5-tert-Butyl-2-methoxy-3-[4-(pyrrolidine-1-carbonyl)-thiazol-2-ylamino]-phenyl}-3-[4-(pyridin-4-yloxy)-naphthalen-1-yl]-urea; 1-[5-tert-Butyl-2-methoxy-3-(4-pyrrolidin-1-ylmethyl-thiazol-2-ylamino)-phenyl]-3-[4-(pyridin-4-yloxy)-naphthalen-1-yl]-urea; 2-(5-tert-Butyl-2-methoxy-3-{3-[4-(pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-phenylamino)-thiazole-4-carboxylic acid ethyl ester; 2-(3-{3-[4-(2-Amino-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-5-tert-butyl-2-methoxy-phenylamino)-thiazole-4-carboxylic acid ethyl ester; 2-(5-tert-Butyl-2-methoxy-3-{3-[4-(2-methylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-phenylamino)-thiazole-4-carboxylic acid ethyl ester; 2-[5-tert-Butyl-3-(3-{4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-2-methoxy-phenylamino]-thiazole-4-carboxylic acid ethyl ester; 2-(5-tert-Butyl-2-methoxy-3-{3-[4-(pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-phenylamino)-thiazole-4-carboxylic acid (2-dimethylamino-ethyl)-methyl-amide; 1-{5-tert-Butyl-2-methoxy-3-[4-(pyrrolidine-1-carbonyl)-thiazol-2-ylamino]-phenyl}-3-[4-(pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-[5-tert-Butyl-2-methoxy-3-(4-pyrrolidin-1-ylmethyl-thiazol-2-ylamino)-phenyl]-3-[4-(pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-[5-tert-Butyl-2-methoxy-3-(4-pyrrolidin-1-ylmethyl-thiazol-2-ylamino)-phenyl]-3-[4-(2-isopropylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-{5-tert-Butyl-2-methoxy-3-[4-(pyrrolidine-1-carbonyl)-thiazol-2-ylamino]-phenyl}-3-{4-[2-(cyclopropylmethyl-amino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl }-urea; 1-[5-tert-Butyl-2-methoxy-3-(4-pyrrolidin-1-ylmethyl-thiazol-2-ylamino)-phenyl]-3-{4-[2-(cyclopropylmethyl-amino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-[5-tert-Butyl-3-(3-dimethylamino-pyrrolidin-1-ylmethyl)-2-methoxy-phenyl]-3-[4-(pyridin-4-yloxy)-naphthalen-1-yl]-urea; 1-[5-tert-Butyl-3-(3-dimethylaminomethyl)-2-methoxy-phenyl]-3-[4-(pyridin-4-yloxy)-naphthalen-1-yl]-urea; 1-[5-tert-Butyl-3-(3-dimethylamino-pyrrolidin-1-ylmethyl)-2-methoxy-phenyl]-3-[4-(2-dimethylaminomethyl-pyridin-4-yloxy)-naphthalen-1-yl]-urea; 1-[5-tert-Butyl-3-(3-dimethylamino-pyrrolidin-1-ylmethyl)-2-methoxy-phenyl]-3-[4-(pyrimidin-4-yloxy)-naphthalen-1-yl]-urea; 1-[4-(2-Amino-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-[5-tert-butyl-3-(3-dimethylamino-pyrrolidin-1-ylmethyl)-2-methoxy-phenyl]-urea; 1-[4-(2-Amino-6-methyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-[5-tert-butyl-3-(3-dimethylamino-pyrrolidin-1-ylmethyl)-2-methoxy-phenyl]-urea; 1-(5-tert-Butyl-3-dimethylaminomethyl-2-methoxy-phenyl)-3-{4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; 1-(5-tert-Butyl-3-dimethylaminomethyl-2-methoxy-phenyl)-3-{4-[2-(cyclopropylmethyl-amino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; N-[5-tert-Butyl-2-methoxy-3-(3-{4-[2-(2-methoxy-phenyl)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-phenyl]-methanesulfonamide; 4-{4-[3-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidine-2-carboxylic acid methyl ester; 1-[4-(2-Acetyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-3-(5-tert-butyl-2-methoxy-phenyl)-urea; N-(3-{3-[4-(2-Acetyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide; 1-(5-tert-Butyl-2-methoxy-phenyl)-3-{4-[2-(1-pyrrolidin-1-yl-ethyl)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea; N-[5-tert-Butyl-2-methoxy-3-(3-{4-[2-(1-pyrrolidin-1-yl-ethyl)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-phenyl]-methanesulfonamide; 1-(2-methoxy-5-trimethylsilanyl-phenyl)-3-{4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-urea or the pharmaceutically acceptable derivatives thereof.
- 5. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to claims 1, 2, 3 or 4.
- 6. A method of treating a cytokine mediated disease or condition which comprises administering to a patient in need of such treatment a therapeutically effective amount of a compound according to claims 1, 2, 3 or 4.
- 7. The method according to claim 6 wherein cytokine mediated disease or condition is selected from rheumatoid arthritis, osteoarthritis, Crohn's disease, ulcerative colitis, multiple sclerosis, Guillain-Barre syndrome, psoriasis, graft versus host disease, systemic lupus erythematosus, percutaneous transluminal coronary angioplasty, diabetes, toxic shock syndrome, Alzheimer's disease, acute and chronic pain, contact dermatitis, atherosclerosis, traumatic arthritis, glomerulonephritis, reperfusion injury, sepsis, bone resorption diseases, chronic obstructive pulmonary disease, congestive heart failure, asthma, stroke, myocardial infarction, thermal injury, adult respiratory distress syndrome (ARDS), multiple organ injury secondary to trauma, dermatoses with acute inflammatory components, acute purulent meningitis, necrotizing entrerocolitis, syndromes associated with hemodialysis, leukopherisis and granulocyte transfusion.
- 8. The method according to claim 7 wherein the disease is selected from rheumatoid arthritis, osteoarthritis, Crohn's disease, psoriasis, ulcerative colitis, osteoporosis, chronic obstructive pulmonary disease, percutaneous transluminal coronary angioplasty and congestive heart failure.
- 9. The method according to claim 8 wherein the disease is selected from rheumatoid arthritis, Crohn's disease, psoriasis, chronic obstructive pulmonary disease, percutaneous transluminal coronary angioplasty and congestive heart failure.
APPLICATION DATA
[0001] This application claims benefit to U.S. provisional application No. 60/291,425 filed May 16, 2001.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60291425 |
May 2001 |
US |