Claims
- 1. A compound of the general formula (I): ##STR32## or an in vivo hydrolyzable pharmaceutically acceptable ester thereof; or a pharmaceutically acceptable salt thereof, wherein R.sup.0 represents a phenyl or naphthyl group which is unsubstituted or substituted with up to five substituents compounding a halogen, alkyl, phenyl, alkoxy, haloalkyl, hydroxy alkyl, hydroxy, amino, nitro, carboxy and pharmaceutically acceptable salts, esters and amides thereof, alkoxycarbonyl, alkoxycarbonyl alkyl alkylcarbonyloxy, or alkylcarbonyl, group; or a benzofuranyl group, which is unsubstituted or substituted with an alkyl group,
- X represents a bond or --O--CH.sub.2,
- R.sup.1 represents a hydrogen atom or a moiety ##STR33## wherein R.sup.0 and X are as defined above; R.sup.2 and R.sup.3 independently represent a hydrogen atom or a straight or branched chain alkyl group having up to 12 carbon atoms,
- n represents an integer 1 or 2,
- Y represents a bond or a moiety --CH.sub.2 --O--, moiety A represents a phenyl or naphthyl group, R.sup.4 represents a bond or an oxygen atom or --R.sup.4A or a moiety --O--R.sup.4A --, or a moiety --R.sup.4A --O--, wherein R.sup.4A represents a C.sub.1-12 alkylene group, a C.sub.1-12 alkyenylene group or a C.sub.1-12 alkynylene group, and R.sup.5 represents a thiazolidine -2,4-dione group, which is unsubstituted or substituted by alkyl; hydroxy; alkoxy; oxo; amino; alkanoyl amino; mono- and di- alkyl amino; mono- and di- alkylaminoalkyl; fluoro, chloro, bromo; carboxy and pharmaceutically acceptable salts, esters and amides thereof; alkanoyloxy, phenyl, naphthyl, phenylalkyl, or naphthylalkyl, wherein the phenyl or naphthyl ring is optionally substituted as in variable R.sup.0.
- 2. A compound according to claim 1 wherein R.sup.4 represents C.sub.1-12 alkylene group.
- 3. A compound according to claim 1 wherein R.sup.4 represents (--CH.sub.2 --).
- 4. A compound according to claim 1, selected from the group consisting of:
- 5-[4-[2-[(.beta.-4-dihydroxyphenethyl)amino]propyl]benzyl]thiazolidine-2,4-dione;
- 5-[4-[2-[(3-chloro-.beta.-hydroxyphenethyl)amino]propyl]-benzyl]thiazolidine-2,4-dione;
- 5-[4-[2[(4-amino-3.5-dichloro-.beta.-hydroxyphenethyl)-amino]propyl]benzyl]thiazolidine-2,4-dione;
- or a pharmaceutically acceptable ester thereof; or a pharmaceutically acceptable salt thereof.
- 5. A compound according to claim 1, represented by formula (II): ##STR34## or a pharmaceutically acceptable ester thereof; or a pharmaceutically acceptable salt thereof, wherein R.sup.3, R.sup.4 and R.sup.5 are as defined in relation to formula (I) and R.sup.11, R.sup.12 and R.sup.13 each independently represent hydrogen; halogen, amino, hydroxy or hydroxymethyl.
- 6. The compound according to claim 5, wherein the halogen is chlorine.
- 7. A pharmaceutical composition comprising a compound of formula (I) as defined in claim 1, or a pharmaceutically acceptable ester thereof; or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.
- 8. A method for the treatment of obesity or hyperglycaemia in a human or non-human animal which method comprises administering an effective, non-toxic, amount of a compound of formula (I) as defined in claim 1 or a pharmaceutically acceptable ester thereof; or a pharmaceutically acceptable salt thereof to a hyperglycaemic human or non-human animal.
- 9. A method for increasing weight gain, improving the feed utilisation efficiency, increasing lean body mass, decreasing birth mortality rate and increasing the post-natal survival rate of livestock, which method comprises the administration to livestock of an effective non-toxic amount of a compound of formula (I) as defined in claim 1 or a veterinarily acceptable ester thereof; or a veterinarily acceptable salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8528633 |
Nov 1985 |
GBX |
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Parent Case Info
This application is a continuation of application Ser. No. 932,320 filed Nov. 19, 1986 now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4287200 |
Kawamatsu |
Sep 1981 |
|
4725610 |
Meguro |
Feb 1988 |
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Foreign Referenced Citations (5)
Number |
Date |
Country |
0239309 |
Sep 1987 |
EPX |
0261763 |
Mar 1988 |
EPX |
277836 |
Aug 1988 |
EPX |
295828 |
Dec 1988 |
EPX |
1938546 |
Mar 1970 |
DEX |
Continuations (1)
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Number |
Date |
Country |
Parent |
932320 |
Nov 1986 |
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