Claims
- 1. An immunogenic composition against Vibrio infection comprising an O-SP unit of LPS of Vibrio associated to a core molecule of LPS of Vibrio or a polymer of said composition.
- 2. The immunogenic composition of claim 1, wherein the O-SP unit associated to the core molecule of LPS of Vibrio is part of a conjugate further comprising a carrier protein.
- 3. The immunogenic composition of claim 2, wherein the Vibrio O-SP unit and core molecule are bound to the carrier protein of the conjugate by a covalent link.
- 4. The immunogenic composition of claim 2, wherein the carrier protein is a bacterial protein.
- 5. The immunogenic composition of claim 4, wherein the bacterial protein is tetanus toxoid.
- 6. The immunogenic composition of claim 1, wherein said composition further comprises an adjuvant and/or a pharmaceutically acceptable carrier.
- 7. The immunogenic composition of claim 1, wherein the LPS is from Vibrio cholera.
- 8. The immunogenic composition of claim 1, wherein the LPS is from Vibrio cholera serogroup O139.
- 9. A vaccine composition protective against infection from Vibrio wherein said vaccine composition comprises an immunogenic composition according to claim 1.
- 10. The vaccine composition of claim 9, wherein said vaccine composition is protective against infection from Vibrio cholerae.
- 11. The vaccine composition of claim 10, wherein said vaccine composition is protective against infection from Vibrio cholerae serogroup O139.
- 12. A method for preparing a conjugate comprising an O-SP unit of LPS from a Vibrio associated to a core molecule of LPS of a Vibrio bound to a protein carrier, said method comprising:
a) providing LPS from a Vibrio; b) hydrolyzing the lipid A-core linkage for obtaining an O-SP unit associated to a core molecule; c) derivatizing the O-SP unit associated to the core molecule of step b); d) bounding the derivatized the O-SP unit associated to the core molecule of step c) to a carrier protein; e) collecting the O-SP unit associated to the core molecule bound to the carrier protein in step d.
- 13. The method of claim 12, wherein the O-SP unit associated to the core molecule are bound to the carrier protein by a covalent link.
- 14. The method of claim 12, wherein the carrier protein is a bacterial protein.
- 15. The method of claim 14, wherein the bacterial protein is tetanus toxoid.
- 16. The method of claim 12, wherein LPS of step a) is from Vibrio cholerae.
- 17. The method of claim 16, wherein LPS of step a) is from Vibrio cholerae serogroup O139.
- 18. Use of a composition comprising a conjugate compound comprising an O-SP unit of LPS of Vibrio associated to a core of LPS of Vibrio bound to a protein carrier for the preparation of a medicament for preventing a Vibrio infection.
- 19. Use of claim 18, wherein Vibrio infection is an infection from Vibrio cholerae.
- 20. Use of claim 19, wherein Vibrio cholerae infection is an infection from Vibrio cholerae serogroup O139.
- 21. A conjugate compound comprising an O-SP unit of LPS of Vibrio associated to a core molecule of LPS of Vibrio bound to a protein carrier.
- 22. The conjugate compound of claim 21, wherein the Vibrio O-SP unit associated to the Vibrio core molecule is bound to the protein carrier by a covalent link.
- 23. The conjugate compound of claim 21, wherein the protein carrier is a bacterial toxin.
- 24. The conjugate compound of claim 23, wherein the bacterial toxin is tetanus toxoid.
- 25. The conjugate compound of claim 21, wherein the Vibrio LPS is from Vibrio cholerae.
- 26. The conjugate compound of claim 25, wherein the Vibrio cholerae LPS is from Vibrio cholerae serogroup O139.
- 27.The composition of claim 1 wherein the O-SP unit and the core are from two different Vibrio.
- 28.The conjugate of claim 21, wherein the O-SP unit and the core are from two different Vibrio.
- 29. Method for immunizing human or animal against Vibrio infection, wherein said method comprises administration to said human or animal of a composition as defined hereabove, wherein Vibrio infection is preferably an infection from Vibrio cholerae and more preferably from Vibrio cholerae serogroup O 139.
Parent Case Info
[0001] This application is based on and claims the benefit of priority of U.S. Provisional Application Serial No. 60/281,783, filed Apr. 6, 2001 (Attorney Docket No. 03495-6067). The entire disclosure of this application is relied upon and incorporated by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60281783 |
Apr 2001 |
US |